Aliases for PSMG4 Gene

Aliases for PSMG4 Gene

  • Proteasome Assembly Chaperone 4 2 3 4 5
  • Proteasome (Prosome, Macropain) Assembly Chaperone 4 2 3
  • C6orf86 3 4
  • PAC-4 3 4
  • HPAC4 3 4
  • PAC4 3 4
  • Chromosome 6 Open Reading Frame 86 2
  • BA506K6.2 3

External Ids for PSMG4 Gene

Previous HGNC Symbols for PSMG4 Gene

  • C6orf86

Previous GeneCards Identifiers for PSMG4 Gene

  • GC06P003203
  • GC06P003255
  • GC06P003137

Summaries for PSMG4 Gene

GeneCards Summary for PSMG4 Gene

PSMG4 (Proteasome Assembly Chaperone 4) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for PSMG4 Gene

Additional gene information for PSMG4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSMG4 Gene

Genomics for PSMG4 Gene

GeneHancer (GH) Regulatory Elements for PSMG4 Gene

Promoters and enhancers for PSMG4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J004016 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 39.4 +788.9 788900 7.4 ZBTB40 ZNF217 EP300 CTCF ZSCAN5C TCF12 SIN3A NRF1 POLR2G SP1 PRPF4B ENSG00000230648 ENSG00000272248 RIPK1 PSMG4 C6orf201 CDYL ENSG00000228170 FAM50B ENSG00000272320
GH06J003156 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 30.2 -70.5 -70450 13.9 HNRNPK ZNF217 EP300 CTCF NRF1 USF1 POLR2G NCOR1 GTF2E2 JUND TUBB2A TUBB2B TUBB2BP1 PRPF4B PSMG4 RIPK1 ENSG00000272320 BPHL C6orf201 LOC105374889
GH06J003226 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 14 -3.0 -3003 8.8 HNRNPK ZNF217 EP300 CTCF TCF12 NRF1 USF1 POLR2G NCOR1 JUND TUBB2B PSMG4 LINC01011 PRPF4B WRNIP1 TUBB2BP1 lnc-TUBB2B-1 lnc-SLC22A23-7 piR-54312-004 LOC100422781-001
GH06J002979 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.6 -245.3 -245283 13.6 HNRNPK FOXK2 ZBTB40 ZNF217 EP300 CTCF ZSCAN5C TCF12 SIN3A MYC NQO2 LINC01011 RF00017-5204 RIPK1 ENSG00000224846 SERPINB9 SERPINB6 ENSG00000232999 ENSG00000272320 PSMG4
GH06J002763 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.8 -464.4 -464402 7.3 HNRNPK ZNF217 EP300 CTCF ZSCAN5C SIN3A MYC NRF1 POLR2G ZNF300 MYLK4 WRNIP1 lnc-MYLK4-1 piR-33136 LINC01011 ENSG00000272320 SERPINB9 ENSG00000232999 PSMG4 NONHSAG042683.2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSMG4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PSMG4

Top Transcription factor binding sites by QIAGEN in the PSMG4 gene promoter:
  • aMEF-2
  • ATF
  • Brachyury
  • FOXC1
  • Gfi-1
  • Lmo2
  • MEF-2A
  • Sp1
  • SRF
  • SRF (504 AA)

Genomic Locations for PSMG4 Gene

Genomic Locations for PSMG4 Gene
71,971 bases
Plus strand
71,971 bases
Plus strand

Genomic View for PSMG4 Gene

Genes around PSMG4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMG4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMG4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMG4 Gene

Proteins for PSMG4 Gene

  • Protein details for PSMG4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Proteasome assembly chaperone 4
    Protein Accession:
    Secondary Accessions:
    • C9J2F8
    • F8WBZ2
    • Q5JS53
    • Q5JS56

    Protein attributes for PSMG4 Gene

    123 amino acids
    Molecular mass:
    13775 Da
    Quaternary structure:
    • Interacts with PSMG3. Associates with alpha subunits of the 20S proteasome (By similarity).

    Three dimensional structures from OCA and Proteopedia for PSMG4 Gene

    Alternative splice isoforms for PSMG4 Gene


neXtProt entry for PSMG4 Gene

Post-translational modifications for PSMG4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PSMG4 Gene

Domains & Families for PSMG4 Gene

Gene Families for PSMG4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PSMG4 Gene


Suggested Antigen Peptide Sequences for PSMG4 Gene

GenScript: Design optimal peptide antigens:
  • Proteasome assembly chaperone 4 (PSMG4_HUMAN)
  • Chromosome 6 open reading frame 86 (Q5JS55_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PSMG4 family.
  • Belongs to the PSMG4 family.
genes like me logo Genes that share domains with PSMG4: view

Function for PSMG4 Gene

Molecular function for PSMG4 Gene

UniProtKB/Swiss-Prot Function:
Chaperone protein which promotes assembly of the 20S proteasome.

Phenotypes From GWAS Catalog for PSMG4 Gene

Phenotypes for PSMG4 Gene

GenomeRNAi human phenotypes for PSMG4:
genes like me logo Genes that share phenotypes with PSMG4: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMG4 Gene

Localization for PSMG4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMG4 gene
Compartment Confidence
extracellular 2
mitochondrion 1
nucleus 1
cytosol 1
lysosome 1
plasma membrane 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PSMG4 Gene

Pathways & Interactions for PSMG4 Gene

PathCards logo

SuperPathways for PSMG4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PSMG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043248 proteasome assembly IEA --
genes like me logo Genes that share ontologies with PSMG4: view

No data available for Pathways by source and SIGNOR curated interactions for PSMG4 Gene

Drugs & Compounds for PSMG4 Gene

No Compound Related Data Available

Transcripts for PSMG4 Gene

mRNA/cDNA for PSMG4 Gene

12 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMG4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6
SP1: -
SP2: - - -
SP3: - -
SP5: - - - - - -
SP6: - - - - - - -

Relevant External Links for PSMG4 Gene

GeneLoc Exon Structure for

Expression for PSMG4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PSMG4 Gene

Protein differential expression in normal tissues from HIPED for PSMG4 Gene

This gene is overexpressed in Urine (40.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMG4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PSMG4

SOURCE GeneReport for Unigene cluster for PSMG4 Gene:


Evidence on tissue expression from TISSUES for PSMG4 Gene

  • Nervous system(3.6)
genes like me logo Genes that share expression patterns with PSMG4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMG4 Gene

Orthologs for PSMG4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PSMG4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PSMG4 31 30
  • 99.38 (n)
(Canis familiaris)
Mammalia -- 31
  • 97 (a)
LOC100855647 30
  • 86.73 (n)
-- 31
  • 79 (a)
(Rattus norvegicus)
Mammalia Psmg4 30
  • 86.21 (n)
(Mus musculus)
Mammalia Psmg4 17 31 30
  • 84.82 (n)
(Bos Taurus)
Mammalia PSMG4 31 30
  • 84.55 (n)
(Monodelphis domestica)
Mammalia PSMG4 31
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia PSMG4 31
  • 76 (a)
(Gallus gallus)
Aves PSMG4 30
  • 78.06 (n)
(Anolis carolinensis)
Reptilia PSMG4 31
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia psmg4 30
  • 63.99 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6942 30
(Danio rerio)
Actinopterygii LOC100333944 30
  • 62.39 (n)
PSMG4 31
  • 55 (a)
Species where no ortholog for PSMG4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PSMG4 Gene

Gene Tree for PSMG4 (if available)
Gene Tree for PSMG4 (if available)
Evolutionary constrained regions (ECRs) for PSMG4: view image

Paralogs for PSMG4 Gene

No data available for Paralogs for PSMG4 Gene

Variants for PSMG4 Gene

Additional dbSNP identifiers (rs#s) for PSMG4 Gene

Structural Variations from Database of Genomic Variants (DGV) for PSMG4 Gene

Variant ID Type Subtype PubMed ID
esv29057 CNV gain 19812545

Variation tolerance for PSMG4 Gene

Gene Damage Index Score: 0.73; 15.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PSMG4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PSMG4 Gene

Disorders for PSMG4 Gene

Additional Disease Information for PSMG4

No disorders were found for PSMG4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMG4 Gene

Publications for PSMG4 Gene

  1. 20S proteasome assembly is orchestrated by two distinct pairs of chaperones in yeast and in mammals. (PMID: 17707236) Le Tallec B … Peyroche A (Molecular cell 2007) 2 3 4 54
  2. An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. (PMID: 29568061) Liu X … Varjosalo M (Nature communications 2018) 3 54
  3. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3 54
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  5. A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells. (PMID: 28700943) Martin TD … Elledge SJ (Cell reports 2017) 3 54

Products for PSMG4 Gene

Sources for PSMG4 Gene