Aliases for PSMG3 Gene

Aliases for PSMG3 Gene

  • Proteasome Assembly Chaperone 3 2 3 4 5
  • Proteasome (Prosome, Macropain) Assembly Chaperone 3 2 3
  • C7orf48 3 4
  • PAC-3 3 4
  • HPAC3 3 4
  • PAC3 3 4
  • Chromosome 7 Open Reading Frame 48 2
  • Proteasome Assembling Chaperone 3 3

External Ids for PSMG3 Gene

Previous HGNC Symbols for PSMG3 Gene

  • C7orf48

Previous GeneCards Identifiers for PSMG3 Gene

  • GC07M001574
  • GC07M001606
  • GC07M001527

Summaries for PSMG3 Gene

GeneCards Summary for PSMG3 Gene

PSMG3 (Proteasome Assembly Chaperone 3) is a Protein Coding gene. Diseases associated with PSMG3 include Hypertensive Retinopathy and Primary Thrombocytopenia.

UniProtKB/Swiss-Prot Summary for PSMG3 Gene

  • Chaperone protein which promotes assembly of the 20S proteasome. May cooperate with PSMG1-PSMG2 heterodimers to orchestrate the correct assembly of proteasomes.

Additional gene information for PSMG3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSMG3 Gene

Genomics for PSMG3 Gene

GeneHancer (GH) Regulatory Elements for PSMG3 Gene

Promoters and enhancers for PSMG3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSMG3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PSMG3

Top Transcription factor binding sites by QIAGEN in the PSMG3 gene promoter:
  • AML1a
  • C/EBPalpha
  • LUN-1
  • p53
  • POU3F1

Genomic Locations for PSMG3 Gene

Genomic Locations for PSMG3 Gene
chr7:1,567,332-1,571,005
(GRCh38/hg38)
Size:
3,674 bases
Orientation:
Minus strand
chr7:1,606,966-1,610,641
(GRCh37/hg19)
Size:
3,676 bases
Orientation:
Minus strand

Genomic View for PSMG3 Gene

Genes around PSMG3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMG3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMG3 Gene

Proteins for PSMG3 Gene

  • Protein details for PSMG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BT73-PSMG3_HUMAN
    Recommended name:
    Proteasome assembly chaperone 3
    Protein Accession:
    Q9BT73
    Secondary Accessions:
    • A4D216
    • A8MPW2

    Protein attributes for PSMG3 Gene

    Size:
    122 amino acids
    Molecular mass:
    13104 Da
    Quaternary structure:
    • Homodimer. Interacts with PSMG4. Interacts directly with alpha and beta subunits of the 20S proteasome but dissociates before the formation of half-proteasomes, probably upon recruitment of POMP.

    Three dimensional structures from OCA and Proteopedia for PSMG3 Gene

neXtProt entry for PSMG3 Gene

Post-translational modifications for PSMG3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PSMG3 Gene

No data available for DME Specific Peptides for PSMG3 Gene

Domains & Families for PSMG3 Gene

Gene Families for PSMG3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PSMG3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PSMG3 Gene

GenScript: Design optimal peptide antigens:
  • Proteasome assembly chaperone 3 (PSMG3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BT73

UniProtKB/Swiss-Prot:

PSMG3_HUMAN :
  • Belongs to the PSMG3 family.
Family:
  • Belongs to the PSMG3 family.
genes like me logo Genes that share domains with PSMG3: view

Function for PSMG3 Gene

Molecular function for PSMG3 Gene

UniProtKB/Swiss-Prot Function:
Chaperone protein which promotes assembly of the 20S proteasome. May cooperate with PSMG1-PSMG2 heterodimers to orchestrate the correct assembly of proteasomes.

Phenotypes From GWAS Catalog for PSMG3 Gene

Phenotypes for PSMG3 Gene

genes like me logo Genes that share phenotypes with PSMG3: view

Animal Model Products

CRISPR Products

miRNA for PSMG3 Gene

miRTarBase miRNAs that target PSMG3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMG3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMG3 Gene

Localization for PSMG3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMG3 gene
Compartment Confidence
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
lysosome 1
peroxisome 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for PSMG3 Gene

Pathways & Interactions for PSMG3 Gene

PathCards logo

SuperPathways for PSMG3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PSMG3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PSMG3 Gene

Drugs & Compounds for PSMG3 Gene

No Compound Related Data Available

Transcripts for PSMG3 Gene

mRNA/cDNA for PSMG3 Gene

2 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMG3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMG3 Gene

No ASD Table

Relevant External Links for PSMG3 Gene

GeneLoc Exon Structure for
PSMG3

Expression for PSMG3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PSMG3 Gene

Protein differential expression in normal tissues from HIPED for PSMG3 Gene

This gene is overexpressed in Oral epithelium (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMG3 Gene



Protein tissue co-expression partners for PSMG3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PSMG3

SOURCE GeneReport for Unigene cluster for PSMG3 Gene:

Hs.446311

Evidence on tissue expression from TISSUES for PSMG3 Gene

  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with PSMG3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMG3 Gene

Orthologs for PSMG3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PSMG3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PSMG3 31 30
  • 87.43 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Psmg3 17 31 30
  • 86.34 (n)
rat
(Rattus norvegicus)
Mammalia Psmg3 30
  • 86.34 (n)
dog
(Canis familiaris)
Mammalia PSMG3 31 30
  • 85.79 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PSMG3 31
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PSMG3 31
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSMG3 31
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves PSMG3 31 30
  • 72.4 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSMG3 31
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psmg3 30
  • 67.23 (n)
Str.728 30
zebrafish
(Danio rerio)
Actinopterygii psmg3 31 30
  • 59.29 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12455 30
Species where no ortholog for PSMG3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PSMG3 Gene

ENSEMBL:
Gene Tree for PSMG3 (if available)
TreeFam:
Gene Tree for PSMG3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PSMG3: view image

Paralogs for PSMG3 Gene

Pseudogenes.org Pseudogenes for PSMG3 Gene

genes like me logo Genes that share paralogs with PSMG3: view

No data available for Paralogs for PSMG3 Gene

Variants for PSMG3 Gene

Additional dbSNP identifiers (rs#s) for PSMG3 Gene

Structural Variations from Database of Genomic Variants (DGV) for PSMG3 Gene

Variant ID Type Subtype PubMed ID
esv2759499 CNV loss 17122850
esv3611812 CNV gain 21293372
nsv5615 CNV deletion 18451855
nsv605820 CNV loss 21841781
nsv830879 CNV gain+loss 17160897
nsv830880 CNV loss 17160897
nsv950786 CNV deletion 24416366

Variation tolerance for PSMG3 Gene

Residual Variation Intolerance Score: 60.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.61; 13.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PSMG3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMG3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PSMG3 Gene

Disorders for PSMG3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PSMG3 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search PSMG3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PSMG3

genes like me logo Genes that share disorders with PSMG3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSMG3 Gene

Publications for PSMG3 Gene

  1. Cooperation of multiple chaperones required for the assembly of mammalian 20S proteasomes. (PMID: 17189198) Hirano Y … Murata S (Molecular cell 2006) 2 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 54
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 54
  5. An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. (PMID: 29568061) Liu X … Varjosalo M (Nature communications 2018) 3 54

Products for PSMG3 Gene

Sources for PSMG3 Gene