Aliases for PSMF1 Gene
Aliases for PSMF1 Gene
External Ids for PSMF1 Gene
- HGNC: 9571
- Entrez Gene: 9491
- Ensembl: ENSG00000125818
- OMIM: 617858
- UniProtKB: Q92530
Previous GeneCards Identifiers for PSMF1 Gene
- GC20P001087
- GC20P001088
- GC20P001041
- GC20P001094
Summaries for PSMF1 Gene
-
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a protein that inhibits the activation of the proteasome by the 11S and 19S regulators. Alternative transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for PSMF1 Gene
PSMF1 (Proteasome Inhibitor Subunit 1) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and RET signaling. Gene Ontology (GO) annotations related to this gene include endopeptidase inhibitor activity and proteasome binding.
UniProtKB/Swiss-Prot for PSMF1 Gene
-
Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMF1 Gene
Genomics for PSMF1 Gene
GeneHancer (GH) Regulatory Elements for PSMF1 Gene
Promoters and enhancers for PSMF1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around PSMF1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PSMF1 gene promoter:
-
- NRSF form 2
- NRSF form 1
Regulatory Element Products
Genomic Locations for PSMF1 Gene
Genomic Locations for PSMF1 Gene
- chr20:1,113,263-1,189,415
- (GRCh38/hg38)
- Size:
- 76,153 bases
- Orientation:
- Plus strand
- chr20:1,093,906-1,160,596
- (GRCh37/hg19)
- Size:
- 66,691 bases
- Orientation:
- Plus strand
Genomic View for PSMF1 Gene
Genes around PSMF1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20p13 by Entrez Gene
- 20p13 by HGNC
- 20p13 by Ensembl
PSMF1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PSMF1 Gene
Proteins for PSMF1 Gene
-
Protein details for PSMF1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q92530-PSMF1_HUMAN
- Recommended name:
- Proteasome inhibitor PI31 subunit
- Protein Accession:
- Q92530
- A0AVQ9
- D3DVW3
- Q9H4I1
Protein attributes for PSMF1 Gene
- Size:
- 271 amino acids
- Molecular mass:
- 29817 Da
- Quaternary structure:
-
- Monomer and homodimer. Interacts with FBXO7. Interacts with the 20S proteasome.
Protein Expression for PSMF1 Gene
Post-translational modifications for PSMF1 Gene
Other Protein References for PSMF1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for PSMF1
-
Abcam antibodies for PSMF1
- Invitrogen Antibodies for PSMF1
- GeneTex PSMF1 Antibody for PSMF1
-
Santa Cruz Biotechnology (SCBT) Antibodies for PSMF1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for PSMF1
- Origene Custom Protein Services for PSMF1
- ProSpec Recombinant Proteins for PSMF1
- Search GeneTex for Proteins for PSMF1
-
Abcam proteins for PSMF1
Assay Products
No data available for DME Specific Peptides for PSMF1 Gene
Domains & Families for PSMF1 Gene
Gene Families for PSMF1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for PSMF1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PSMF1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q92530- Family:
-
- Belongs to the proteasome inhibitor PI31 family.
Function for PSMF1 Gene
Molecular function for PSMF1 Gene
- UniProtKB/Swiss-Prot Function:
- Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.
Phenotypes From GWAS Catalog for PSMF1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004866 | endopeptidase inhibitor activity | NAS | 10764772 |
| GO:0005515 | protein binding | IPI | 16000308 |
| GO:0042803 | protein homodimerization activity | IDA | 18495667 |
| GO:0046982 | protein heterodimerization activity | IPI | 18495667 |
| GO:0070628 | proteasome binding | IDA | 10764772 |
Phenotypes for PSMF1 Gene
- MGI mutant phenotypes for PSMF1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PSMF1:
-
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Resistant to vaccinia virus (VACV-A4L) infection
- Synthetic lethal with Ras
- Decreased infection with West Nile virus (WNV)
- Decreased West Nile virus (WNV) infection
- shRNA abundance <= 50%
- Decreased IL-8 secretion
Animal Models for PSMF1 Gene
- MGI Knock Outs for PSMF1:
-
- Psmf1 Psmf1<tm1b(EUCOMM)Hmgu>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PSMF1
-
CRISPR Products
-
OriGene CRISPR knockouts for PSMF1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PSMF1
- genomics-online: gRNA clones - Search results for available PSMF1 gene related products
- Applied Biological Materials CRISPR for PSMF1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSMF1
- GenScript: Design CRISPR guide RNA sequences for PSMF1
miRNA for PSMF1 Gene
- miRTarBase miRNAs that target PSMF1
-
- hsa-mir-615-3p (MIRT039672)
- hsa-mir-151a-3p (MIRT043618)
- hsa-mir-320a (MIRT044684)
- hsa-mir-92a-3p (MIRT049749)
- hsa-mir-518c-5p (MIRT470124)
- hsa-mir-6515-5p (MIRT470125)
- hsa-mir-6797-5p (MIRT470126)
- hsa-mir-1249-5p (MIRT470127)
- hsa-mir-671-5p (MIRT470128)
- hsa-mir-661 (MIRT470129)
- hsa-mir-4768-3p (MIRT470130)
- hsa-mir-6736-3p (MIRT470131)
- hsa-mir-4802-5p (MIRT470132)
- hsa-mir-9500 (MIRT470133)
- hsa-mir-665 (MIRT470134)
- hsa-mir-6773-5p (MIRT718190)
- hsa-mir-6724-5p (MIRT718191)
- hsa-mir-296-5p (MIRT718192)
- hsa-mir-6721-5p (MIRT718193)
- hsa-mir-6775-3p (MIRT718194)
- hsa-mir-1291 (MIRT718195)
- hsa-mir-6860 (MIRT718196)
- hsa-mir-612 (MIRT718197)
- hsa-mir-5189-5p (MIRT718198)
- hsa-mir-3187-5p (MIRT718199)
- hsa-mir-1285-3p (MIRT718200)
- hsa-mir-939-3p (MIRT718201)
- hsa-mir-6791-5p (MIRT718202)
- hsa-mir-4292 (MIRT718203)
- hsa-mir-451b (MIRT718204)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for PSMF1
- Browse OriGene Inhibitory RNA Products For PSMF1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMF1
- genomics-online: shRNA clones - Search results for available PSMF1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for PSMF1
- VectorBuilder custom plasmid, inducible vectors for PSMF1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PSMF1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PSMF1
- genomics-online: cdna clones - Search results for available PSMF1 gene related products
- orf clones - Search results for available PSMF1 gene related products
- Applied Biological Materials Clones for PSMF1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PSMF1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PSMF1 Gene
Localization for PSMF1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PSMF1 Gene
- Cytoplasm. Endoplasmic reticulum.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| endoplasmic reticulum | 5 |
| cytosol | 5 |
| extracellular | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
- Cytosol (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000502 | proteasome complex | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005783 | endoplasmic reticulum | IDA,IEA | 18495667 |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for PSMF1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | CDK-mediated phosphorylation and removal of Cdc6 |
.93
.93
|
.80
.78
.78
.70
.47
.31
|
| 2 | RET signaling |
.92
|
.92
|
| 3 | HIV Life Cycle |
.64
|
.45
|
| 4 | Class I MHC mediated antigen processing and presentation | ||
| 5 | Cell Cycle, Mitotic |
.83
|
.60
|
Pathways by source for PSMF1 Gene
1 KEGG pathway for PSMF1 Gene
Interacting Proteins for PSMF1 Gene
Selected Interacting proteins:
Q92530-PSMF1_HUMAN
ENSP00000327704
for PSMF1 Gene via
MINT
STRING
UniProtKB
IID
GPS-Prot Interaction Network for PSMF1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
| GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
| GO:0006511 | ubiquitin-dependent protein catabolic process | IDA | 10764772 |
No data available for SIGNOR curated interactions for PSMF1 Gene
Drugs & Compounds for PSMF1 Gene
Transcripts for PSMF1 Gene
mRNA/cDNA for PSMF1 Gene
- (8) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (541) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000381899 704 bps (uc061uxa.1)
- ENST00000479715 660 bps (uc061uxb.1)
- ENST00000246015 2042 bps (uc061uxd.1)
- ENST00000335877 4290 bps (uc002wen.5)
- ENST00000478004 632 bps (uc061uxe.1)
Unigene Clusters for PSMF1 Gene
- Proteasome (prosome, macropain) inhibitor subunit 1 (PI31):
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for PSMF1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PSMF1
- genomics-online: gRNA clones - Search results for available PSMF1 gene related products
- Applied Biological Materials CRISPR for PSMF1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSMF1
- GenScript: Design CRISPR guide RNA sequences for PSMF1
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for PSMF1
- Browse OriGene Inhibitory RNA Products For PSMF1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMF1
- genomics-online: shRNA clones - Search results for available PSMF1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for PSMF1
- VectorBuilder custom plasmid, inducible vectors for PSMF1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PSMF1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PSMF1
- genomics-online: cdna clones - Search results for available PSMF1 gene related products
- orf clones - Search results for available PSMF1 gene related products
- Applied Biological Materials Clones for PSMF1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP7: |
Expression for PSMF1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Proerythroblasts Hematopoietic Bone Marrow
- Hematopoietic Bone Marrow
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
- Brain (Nervous System)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
- Pancreas (Endocrine System)
- Ovary (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Adipose (Muscoskeletal System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMF1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of PSMF1 Gene:
PSMF1SOURCE GeneReport for Unigene cluster for PSMF1 Gene:
Hs.471917Evidence on tissue expression from TISSUES for PSMF1 Gene
- Nervous system(4.6)
- Liver(4.4)
- Skin(2.9)
- Lung(2.7)
- Eye(2.5)
- Intestine(2.5)
Primer Products
-
OriGene qPCR primer pairs and template standards for PSMF1
-
OriGene qPCR primer pairs for PSMF1
- genomics-online: primer clones - Search results for available PSMF1 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMF1 Gene
Orthologs for PSMF1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PSMF1 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | PSMF1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | PSMF1 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Psmf1 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Psmf1 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PSMF1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PSMF1 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | PSMF1 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | psmf1 34 33 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007418 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | PI31 33 |
|
- Species where no ortholog for PSMF1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for PSMF1 Gene
- ENSEMBL:
- Gene Tree for PSMF1 (if available)
- TreeFam:
- Gene Tree for PSMF1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PSMF1: view image
Paralogs for PSMF1 Gene
No data available for Paralogs for PSMF1 Gene
Variants for PSMF1 Gene
| SNP ID | Clin | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000035453 | -- | 1,147,587(+) | G/A | intron_variant | |
| rs1000037453 | -- | 1,116,297(+) | G/A/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000041244 | -- | 1,111,433(+) | T/C | upstream_transcript_variant | |
| rs1000041602 | -- | 1,113,304(+) | T/C | 5_prime_UTR_variant, genic_upstream_transcript_variant | |
| rs1000107092 | -- | 1,154,090(+) | C/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv648e201 | CNV | deletion | 23290073 |
| dgv649e201 | CNV | deletion | 23290073 |
| dgv650e201 | CNV | deletion | 23290073 |
| dgv651e201 | CNV | deletion | 23290073 |
| esv1136177 | CNV | insertion | 17803354 |
| esv2524932 | CNV | deletion | 19546169 |
| esv2666587 | CNV | deletion | 23128226 |
| esv2674425 | CNV | deletion | 23128226 |
| esv2722050 | CNV | deletion | 23290073 |
| esv2722052 | CNV | deletion | 23290073 |
| esv2722058 | CNV | deletion | 23290073 |
| esv2722059 | CNV | deletion | 23290073 |
| esv2722060 | CNV | deletion | 23290073 |
| esv3306542 | CNV | mobile element insertion | 20981092 |
| esv3363197 | CNV | insertion | 20981092 |
| esv3575346 | CNV | gain | 25503493 |
| esv3575348 | CNV | gain | 25503493 |
| esv3644952 | CNV | gain | 21293372 |
| esv3644974 | CNV | loss | 21293372 |
| nsv1057097 | CNV | gain | 25217958 |
| nsv179100 | CNV | deletion | 16902084 |
| nsv179964 | CNV | deletion | 16902084 |
| nsv964368 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
69.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.72;
57.54% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PSMF1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PSMF1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMF1 Gene
Disorders for PSMF1 Gene
Additional Disease Information for PSMF1
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for PSMF1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMF1 Gene
Publications for PSMF1 Gene
- Structure of a conserved dimerization domain within the F-box protein Fbxo7 and the PI31 proteasome inhibitor. (PMID: 18495667) Kirk R … McDonald NQ (The Journal of biological chemistry 2008) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
- cDNA cloning, expression, and functional characterization of PI31, a proline-rich inhibitor of the proteasome. (PMID: 10764772) McCutchen-Maloney SL … DeMartino GN (The Journal of biological chemistry 2000) 3 4 58
- The proteasome-dependent proteolytic system. (PMID: 10363639) Tanahashi N … Tanaka K (Molecular biology reports 1999) 2 3 58
Products for PSMF1 Gene
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- Browse R&D Systems for biochemical assays
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- Custom Antibody Services
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- Search Origene for MassSpec and Protein Over-expression Lysates for PSMF1
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- OriGene qPCR primer pairs and template standards for PSMF1
- OriGene qPCR primer pairs for PSMF1
- OriGene CRISPR knockouts for PSMF1
- OriGene ORF clones in human for PSMF1
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- GenScript: Next-day shipping of latest version cDNA ORF clones for PSMF1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for PSMF1
- GenScript Custom Assay Services for PSMF1
- GenScript Custom overexpressing Cell Line Services for PSMF1
- GenScript: Design CRISPR guide RNA sequences for PSMF1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for PSMF1
- Sino Biological Human cDNA Clone for PSMF1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for PSMF1
- Novus Biologicals proteins and lysates for PSMF1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
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- Abcam antibodies for PSMF1
- Abcam proteins for PSMF1
- Find your target
- Browse Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
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- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for PSMF1
- Cyagen custom Knockout/knockin (KOKI) mouse models for PSMF1
- VectorBuilder custom plasmid, inducible vectors for PSMF1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PSMF1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 50 available PSMF1 Antibodies ranked by validation data
- Compare Top PSMF1 Antibodies
- antibodies-online: Search results for available PSMF1 related products ranked by validation data
- antibodies-online: Search results for 13 available PSMF1 Proteins ranked by validation data
- Compare Top PSMF1 Proteins
- GeneTex PSMF1 Antibody for PSMF1
- Search GeneTex for Proteins for PSMF1
- Santa Cruz Biotechnology (SCBT) Antibodies for PSMF1
- Search Santa Cruz Biotechnology (SCBT) for PSMF1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PSMF1
- Horizon Cell Lines for PSMF1
- genomics-online: cdna clones - Search results for available PSMF1 gene related products
- orf clones - Search results for available PSMF1 gene related products
- genomics-online: gRNA clones - Search results for available PSMF1 gene related products
- genomics-online: primer clones - Search results for available PSMF1 gene related products
- genomics-online: shRNA clones - Search results for available PSMF1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PSMF1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PSMF1
- GeneCopoeia miRNA 3'UTR Target clone products for PSMF1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMF1
Sources for PSMF1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84)