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Aliases for PSME4 Gene

Aliases for PSME4 Gene

  • Proteasome Activator Subunit 4 2 3 5
  • Proteasome (Prosome, Macropain) Activator Subunit 4 2 3
  • Proteasome Activator PA200 3 4
  • Proteasome Activator Complex Subunit 4 3
  • Proteasome Activator 200 KDa 3
  • KIAA0077 4
  • PA200 3

External Ids for PSME4 Gene

Previous GeneCards Identifiers for PSME4 Gene

  • GC02M054048
  • GC02M054066
  • GC02M054003
  • GC02M054091
  • GC02M053825

Summaries for PSME4 Gene

GeneCards Summary for PSME4 Gene

PSME4 (Proteasome Activator Subunit 4) is a Protein Coding gene. Among its related pathways are RET signaling and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include binding and peptidase activator activity.

UniProtKB/Swiss-Prot for PSME4 Gene

  • Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.

Gene Wiki entry for PSME4 Gene

Additional gene information for PSME4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSME4 Gene

Genomics for PSME4 Gene

GeneHancer (GH) Regulatory Elements for PSME4 Gene

Promoters and enhancers for PSME4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I053967 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 555.4 +0.8 809 4.7 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF207 ACYP2 PSME4 HMGB1P31 ASB3 GPR75-ASB3
GH02I054767 Enhancer 0.8 Ensembl ENCODE 4.4 -797.1 -797087 1.6 JUN ZSCAN4 JUNB ATF4 PRDM6 JUND ZNF366 ZBTB12 PRDM1 LOC105374667 EML6 RTN4 SPTBN1 PSME4 GC02P054774
GH02I053993 Enhancer 1.1 FANTOM5 Ensembl ENCODE 2.3 -23.8 -23771 2.8 ZNF362 ZBTB11 JUNB ZC3H11A ZNF781 ZNF518A ZNF697 ZNF555 ZBTB33 RUNX3 ACYP2 HMGB1P31 ASB3 PSME4 GC02P053991 GC02P054007
GH02I053738 Enhancer 0.4 FANTOM5 3.3 +231.7 231726 0.4 HNF4A GPR75 PSME4 GC02P053747 ASB3 GC02M053662 GPR75-ASB3
GH02I053964 Enhancer 1.1 Ensembl ENCODE dbSUPER 0.4 +5.9 5948 1 ZSCAN4 BATF ZNF7 ZNF316 ATF7 IKZF2 RUNX3 ZNF362 HLF JUNB ACYP2 PSME4 GPR75-ASB3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PSME4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PSME4 gene promoter:

Genomic Locations for PSME4 Gene

Genomic Locations for PSME4 Gene
chr2:53,864,067-53,970,840
(GRCh38/hg38)
Size:
106,774 bases
Orientation:
Minus strand
chr2:54,091,204-54,197,977
(GRCh37/hg19)

Genomic View for PSME4 Gene

Genes around PSME4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSME4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSME4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSME4 Gene

Proteins for PSME4 Gene

  • Protein details for PSME4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14997-PSME4_HUMAN
    Recommended name:
    Proteasome activator complex subunit 4
    Protein Accession:
    Q14997
    Secondary Accessions:
    • Q1XBG4
    • Q1XBG5
    • Q1XBG6
    • Q2M1Z0
    • Q6IPR2
    • Q86XF8

    Protein attributes for PSME4 Gene

    Size:
    1843 amino acids
    Molecular mass:
    211334 Da
    Quaternary structure:
    • Homodimer. Interacts with the 20S and 26S proteasomes. Component of the spermatoproteasome, a form of the proteasome specifically found in testis.
    SequenceCaution:
    • Sequence=AAI12170.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI13669.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PSME4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSME4 Gene

Post-translational modifications for PSME4 Gene

Other Protein References for PSME4 Gene

No data available for DME Specific Peptides for PSME4 Gene

Domains & Families for PSME4 Gene

Gene Families for PSME4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PSME4 Gene

Suggested Antigen Peptide Sequences for PSME4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14997

UniProtKB/Swiss-Prot:

PSME4_HUMAN :
  • The bromodomain-like (BRDL) region specifically recognizes and binds acetylated histones.
  • Belongs to the BLM10 family.
Domain:
  • The bromodomain-like (BRDL) region specifically recognizes and binds acetylated histones.
Family:
  • Belongs to the BLM10 family.
genes like me logo Genes that share domains with PSME4: view

Function for PSME4 Gene

Molecular function for PSME4 Gene

UniProtKB/Swiss-Prot Function:
Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.

Phenotypes From GWAS Catalog for PSME4 Gene

Gene Ontology (GO) - Molecular Function for PSME4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016504 peptidase activator activity ISS,IEA --
GO:0070577 lysine-acetylated histone binding IEA,ISS --
GO:0070628 proteasome binding IBA,IEA --
genes like me logo Genes that share ontologies with PSME4: view
genes like me logo Genes that share phenotypes with PSME4: view

Animal Models for PSME4 Gene

MGI Knock Outs for PSME4:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PSME4 Gene

Localization for PSME4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSME4 Gene

Cytoplasm, cytosol. Nucleus. Nucleus speckle. Note=Found in nuclear foci following treatment with ionizing radiation, but not with ultraviolet irradiation or H(2)O(2).

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSME4 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PSME4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IEA --
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS,IBA --
genes like me logo Genes that share ontologies with PSME4: view

Pathways & Interactions for PSME4 Gene

SuperPathways for PSME4 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 HIV Life Cycle
.45
4 Class I MHC mediated antigen processing and presentation
5 Cell Cycle, Mitotic
.60
genes like me logo Genes that share pathways with PSME4: view

Gene Ontology (GO) - Biological Process for PSME4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006281 DNA repair ISS --
genes like me logo Genes that share ontologies with PSME4: view

No data available for SIGNOR curated interactions for PSME4 Gene

Drugs & Compounds for PSME4 Gene

(2) Drugs for PSME4 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 826
carfilzomib Approved, Investigational Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
genes like me logo Genes that share compounds with PSME4: view

Transcripts for PSME4 Gene

Unigene Clusters for PSME4 Gene

Proteasome (prosome, macropain) activator subunit 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSME4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a ·
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

ExUns: 25b ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40a · 40b ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^ 46 ^ 47a · 47b · 47c ^
SP1: - - - - -
SP2:
SP3: - - - -
SP4: - -
SP5:
SP6:
SP7:
SP8:

ExUns: 48 ^ 49 ^ 50a · 50b · 50c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for PSME4 Gene

GeneLoc Exon Structure for
PSME4
ECgene alternative splicing isoforms for
PSME4

Expression for PSME4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSME4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PSME4 Gene

This gene is overexpressed in Muscle - Skeletal (x6.1).

Protein differential expression in normal tissues from HIPED for PSME4 Gene

This gene is overexpressed in Ovary (31.7) and Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSME4 Gene



Protein tissue co-expression partners for PSME4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PSME4 Gene:

PSME4

SOURCE GeneReport for Unigene cluster for PSME4 Gene:

Hs.413801

Evidence on tissue expression from TISSUES for PSME4 Gene

  • Nervous system(4.5)
  • Bone marrow(4.3)
  • Muscle(4.3)
genes like me logo Genes that share expression patterns with PSME4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSME4 Gene

Orthologs for PSME4 Gene

This gene was present in the common ancestor of animals.

Orthologs for PSME4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSME4 33 34
  • 99.6 (n)
dog
(Canis familiaris)
Mammalia PSME4 33 34
  • 94.18 (n)
cow
(Bos Taurus)
Mammalia PSME4 33 34
  • 93.74 (n)
oppossum
(Monodelphis domestica)
Mammalia PSME4 34
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Psme4 33 16 34
  • 91.12 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PSME4 34
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psme4 33
  • 90.78 (n)
chicken
(Gallus gallus)
Aves PSME4 33 34
  • 81.7 (n)
lizard
(Anolis carolinensis)
Reptilia PSME4 34
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psme4 33
  • 75.59 (n)
Str.11346 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.25803 33
zebrafish
(Danio rerio)
Actinopterygii psme4a 34
  • 74 (a)
OneToMany
PSME4 (3 of 4) 34
  • 73 (a)
OneToMany
BX663524.3 34
  • 72 (a)
OneToMany
psme4b 33 34
  • 69.16 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002597 33
  • 44.25 (n)
worm
(Caenorhabditis elegans)
Secernentea C14C10.5 33 34
  • 45.12 (n)
T28B8.3 34
  • 21 (a)
OneToMany
T28B8.4 34
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 42 (a)
OneToOne
Species where no ortholog for PSME4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSME4 Gene

ENSEMBL:
Gene Tree for PSME4 (if available)
TreeFam:
Gene Tree for PSME4 (if available)

Paralogs for PSME4 Gene

No data available for Paralogs for PSME4 Gene

Variants for PSME4 Gene

Sequence variations from dbSNP and Humsavar for PSME4 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000055224 -- 53,909,152(-) C/G intron_variant
rs1000064849 -- 53,947,909(-) G/T intron_variant
rs1000128702 -- 53,865,881(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000133169 -- 53,926,784(-) C/A intron_variant
rs1000137677 -- 53,937,075(-) TTATTTA/TTA intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PSME4 Gene

Variant ID Type Subtype PubMed ID
esv2484606 CNV deletion 19546169
esv2720077 CNV deletion 23290073
esv2720078 CNV deletion 23290073
esv2762257 CNV loss 21179565
esv3590830 CNV loss 21293372
esv3590831 CNV loss 21293372
nsv1001246 CNV gain 25217958
nsv1123326 CNV deletion 24896259
nsv829423 CNV loss 20364138

Variation tolerance for PSME4 Gene

Residual Variation Intolerance Score: 0.669% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.64; 94.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PSME4 Gene

Human Gene Mutation Database (HGMD)
PSME4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSME4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSME4 Gene

Disorders for PSME4 Gene

Additional Disease Information for PSME4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PSME4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSME4 Gene

Publications for PSME4 Gene

  1. PA200, a nuclear proteasome activator involved in DNA repair. (PMID: 12093752) Ustrell V … Rechsteiner M (The EMBO journal 2002) 2 3 4 58
  2. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7584044) Nomura N … Tabata S (DNA research : an international journal for rapid publication of reports on genes and genomes 1994) 2 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X … Huang L (Biochemistry 2007) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for PSME4 Gene

Sources for PSME4 Gene

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