Aliases for PSME3IP1 Gene

Aliases for PSME3IP1 Gene

  • Proteasome Activator Subunit 3 Interacting Protein 1 2 3
  • Family With Sequence Similarity 192 Member A 2 3 5
  • NEFA-Interacting Nuclear Protein NIP30 3 4
  • PA28G Interacting Protein 30kDa 2 3
  • PSME3 Interacting Protein 30kDa 2 3
  • PSME3-Interacting Protein 3 4
  • PA28G-Interacting Protein 3 4
  • C16orf94 3 4
  • FAM192A 3 5
  • NIP30 3 4
  • PIP30 3 4
  • NEFA Interacting Nuclear Protein NIP30 2
  • Chromosome 16 Open Reading Frame 94 2
  • Protein FAM192A 3
  • CDA018 3
  • CDA10 3

External Ids for PSME3IP1 Gene

Previous HGNC Symbols for PSME3IP1 Gene

  • C16orf94
  • FAM192A

Summaries for PSME3IP1 Gene

GeneCards Summary for PSME3IP1 Gene

PSME3IP1 (Proteasome Activator Subunit 3 Interacting Protein 1) is a Protein Coding gene. Diseases associated with PSME3IP1 include Acute Maxillary Sinusitis.

UniProtKB/Swiss-Prot Summary for PSME3IP1 Gene

  • Promotes the association of the proteasome activator complex subunit PSME3 with the 20S proteasome and regulates its activity. Inhibits PSME3-mediated degradation of some proteasome substrates, probably by affecting their diffusion rate into the catalytic chamber of the proteasome. Also inhibits the interaction of PSME3 with COIL, inhibits accumulation of PSME3 in Cajal bodies and positively regulates the number of Cajal bodies in the nucleus.

Gene Wiki entry for PSME3IP1 Gene

Additional gene information for PSME3IP1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSME3IP1 Gene

Genomics for PSME3IP1 Gene

GeneHancer (GH) Regulatory Elements for PSME3IP1 Gene

Promoters and enhancers for PSME3IP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J057183 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 521.4 -0.3 -336 5.1 FOXK2 HNRNPK ZBTB40 ZSCAN5C SIN3A NRF1 POLR2G USF1 SP1 NCOR1 RSPRY1 PSME3IP1 lnc-PLLP-3 PLLP NUDT21 NUP93 piR-56759-209
GH16J057446 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 500.1 -261.2 -261171 2.8 HNRNPK ZBTB40 ZNF217 EP300 SIN3A TCF12 POLR2G SP1 NCOR1 PHF8 CIAPIN1 COQ9 PSME3IP1 RSPRY1 ADGRG5 DOK4 CCDC102A lnc-COQ9-1
GH16J057173 Promoter 0.3 EPDnew 500.4 +12.4 12367 0.1 PSME3IP1 NLRC5 ENSG00000285979 piR-61945-186
GH16J057138 Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas dbSUPER 31 +42.1 42149 11.4 CTCF ZIC2 RFX1 CTBP1 NR2F2 NCOR1 RELA TCF12 GABPA RAD21 ENSG00000279019 ENSG00000279803 piR-61945-186 PSME3IP1 PLLP CPNE2 RSPRY1 ARL2BP ENSG00000261114 BBS2
GH16J057258 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 19 -79.8 -79771 14 USF1 JUND TEAD4 FOS EP300 ZIC2 ZNF263 ZBTB11 RELA MYC PLLP PSME3IP1 CPNE2 ADGRG1 lnc-PLLP-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSME3IP1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PSME3IP1

Genomic Locations for PSME3IP1 Gene

Genomic Locations for PSME3IP1 Gene
chr16:57,152,466-57,186,230
(GRCh38/hg38)
Size:
33,765 bases
Orientation:
Minus strand
chr16:57,186,378-57,220,028
(GRCh37/hg19)
Size:
33,651 bases
Orientation:
Minus strand

Genomic View for PSME3IP1 Gene

Genes around PSME3IP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSME3IP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSME3IP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSME3IP1 Gene

Proteins for PSME3IP1 Gene

  • Protein details for PSME3IP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZU8-PIP30_HUMAN
    Recommended name:
    PSME3-interacting protein
    Protein Accession:
    Q9GZU8

    Protein attributes for PSME3IP1 Gene

    Size:
    254 amino acids
    Molecular mass:
    28912 Da
    Quaternary structure:
    • Interacts (via C-terminus) with both free and 20S proteasome-bound forms of the proteasome activator complex subunit PSME3; the interaction is direct.

neXtProt entry for PSME3IP1 Gene

Post-translational modifications for PSME3IP1 Gene

  • Phosphorylation by CK2 stabilizes the interaction with PSME3.
  • Ubiquitination at Lys151
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PSME3IP1 Gene

Domains & Families for PSME3IP1 Gene

Gene Families for PSME3IP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PSME3IP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PSME3IP1 Gene

GenScript: Design optimal peptide antigens:
  • NEFA-interacting nuclear protein NIP30 (F192A_HUMAN)
  • NIP30 protein (Q6P4H7_HUMAN)
genes like me logo Genes that share domains with PSME3IP1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PSME3IP1 Gene

Function for PSME3IP1 Gene

Molecular function for PSME3IP1 Gene

UniProtKB/Swiss-Prot Function:
Promotes the association of the proteasome activator complex subunit PSME3 with the 20S proteasome and regulates its activity. Inhibits PSME3-mediated degradation of some proteasome substrates, probably by affecting their diffusion rate into the catalytic chamber of the proteasome. Also inhibits the interaction of PSME3 with COIL, inhibits accumulation of PSME3 in Cajal bodies and positively regulates the number of Cajal bodies in the nucleus.

Phenotypes From GWAS Catalog for PSME3IP1 Gene

Gene Ontology (GO) - Molecular Function for PSME3IP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with PSME3IP1: view
genes like me logo Genes that share phenotypes with PSME3IP1: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSME3IP1 Gene

Localization for PSME3IP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSME3IP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSME3IP1 gene
Compartment Confidence
nucleus 5
extracellular 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PSME3IP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 29934401
genes like me logo Genes that share ontologies with PSME3IP1: view

Pathways & Interactions for PSME3IP1 Gene

PathCards logo

SuperPathways for PSME3IP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PSME3IP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032091 negative regulation of protein binding IMP 29934401
GO:1901799 negative regulation of proteasomal protein catabolic process IMP 29934401
genes like me logo Genes that share ontologies with PSME3IP1: view

No data available for Pathways by source and SIGNOR curated interactions for PSME3IP1 Gene

Drugs & Compounds for PSME3IP1 Gene

No Compound Related Data Available

Transcripts for PSME3IP1 Gene

mRNA/cDNA for PSME3IP1 Gene

26 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
21 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSME3IP1 Gene

No ASD Table

Relevant External Links for PSME3IP1 Gene

GeneLoc Exon Structure for
PSME3IP1

Expression for PSME3IP1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PSME3IP1

SOURCE GeneReport for Unigene cluster for PSME3IP1 Gene:

Hs.396740

Evidence on tissue expression from TISSUES for PSME3IP1 Gene

  • Eye(4.3)
  • Intestine(4.3)
  • Lymph node(4.3)
  • Nervous system(4.3)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSME3IP1 Gene

Orthologs for PSME3IP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PSME3IP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM192A 31 30
  • 99.48 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NIP30 31
  • 96 (a)
OneToOne
FAM192A 30
  • 92.23 (n)
dog
(Canis familiaris)
Mammalia FAM192A 31 30
  • 91.6 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nip30 30
  • 88.8 (n)
mouse
(Mus musculus)
Mammalia Fam192a 17 31 30
  • 88.54 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM192A 31
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM192A 31
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM192A 31 30
  • 77.03 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM192A 31
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam192a 30
  • 65.61 (n)
Str.11948 30
African clawed frog
(Xenopus laevis)
Amphibia nip30-prov 30
zebrafish
(Danio rerio)
Actinopterygii fam192a 31 30
  • 65.37 (n)
OneToOne
wufa02g12 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010768 30
  • 52 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14480 31 30
  • 49.35 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C25A1.1 31
  • 37 (a)
OneToOne
Species where no ortholog for PSME3IP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSME3IP1 Gene

ENSEMBL:
Gene Tree for PSME3IP1 (if available)
TreeFam:
Gene Tree for PSME3IP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PSME3IP1: view image

Paralogs for PSME3IP1 Gene

Pseudogenes.org Pseudogenes for PSME3IP1 Gene

genes like me logo Genes that share paralogs with PSME3IP1: view

No data available for Paralogs for PSME3IP1 Gene

Variants for PSME3IP1 Gene

Additional dbSNP identifiers (rs#s) for PSME3IP1 Gene

Variation tolerance for PSME3IP1 Gene

Residual Variation Intolerance Score: 35.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 7.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PSME3IP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSME3IP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for PSME3IP1 Gene

Disorders for PSME3IP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PSME3IP1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
acute maxillary sinusitis
  • acute antritis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PSME3IP1

genes like me logo Genes that share disorders with PSME3IP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSME3IP1 Gene

Publications for PSME3IP1 Gene

  1. PIP30/FAM192A is a novel regulator of the nuclear proteasome activator PA28γ. (PMID: 29934401) Jonik-Nowak B … Coux O (Proceedings of the National Academy of Sciences of the United States of America 2018) 2 3 4 54
  2. Isolation, expression analysis and characterization of NEFA-interacting nuclear protein 30 and RING finger and SPRY domain containing 1 in skeletal muscle. (PMID: 26497270) Waddell DS … Eldredge JT (Gene 2016) 2 3 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins. (PMID: 29513927) Tomkins JE … Manzoni C (Proteomics 2018) 3 54

Products for PSME3IP1 Gene

Sources for PSME3IP1 Gene