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Aliases for PSME3 Gene

Aliases for PSME3 Gene

  • Proteasome Activator Subunit 3 2 3 5
  • Proteasome (Prosome, Macropain) Activator Subunit 3 (PA28 Gamma; Ki) 2 3
  • Activator Of Multicatalytic Protease Subunit 3 3 4
  • Proteasome Activator 28 Subunit Gamma 3 4
  • 11S Regulator Complex Subunit Gamma 3 4
  • Ki Nuclear Autoantigen 3 4
  • REG-GAMMA 3 4
  • PA28gamma 3 4
  • PA28G 3 4
  • Proteasome Activator Complex Subunit 3 3
  • 11S Regulator Complex Gamma Subunit 3
  • Epididymis Secretory Protein Li 283 3
  • Proteasome Activator 28-Gamma 3
  • PA28 Gamma Variant 5 3
  • REG Gamma-3 3
  • Ki Antigen 3
  • PA28-Gamma 3
  • HEL-S-283 3
  • Ki 3

External Ids for PSME3 Gene

Previous GeneCards Identifiers for PSME3 Gene

  • GC17M040635
  • GC17P043138
  • GC17P040885
  • GC17P041358
  • GC17P038238
  • GC17P040985
  • GC17P036749

Summaries for PSME3 Gene

Entrez Gene Summary for PSME3 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

GeneCards Summary for PSME3 Gene

PSME3 (Proteasome Activator Subunit 3) is a Protein Coding gene. Among its related pathways are RET signaling and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include identical protein binding and MDM2/MDM4 family protein binding. An important paralog of this gene is PSME1.

UniProtKB/Swiss-Prot for PSME3 Gene

  • Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (PubMed:25361978).

Gene Wiki entry for PSME3 Gene

Additional gene information for PSME3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSME3 Gene

Genomics for PSME3 Gene

GeneHancer (GH) Regulatory Elements for PSME3 Gene

Promoters and enhancers for PSME3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I042832 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.4 +9.3 9256 3.1 HDGF PKNOX1 CLOCK FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 BECN1 PSME3 NKIRAS2 MEOX1 ENSG00000212149 PTGES3L-AARSD1 RPL27 CNTD1 COA3 STAT3
GH17I042823 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 -0.3 -308 1.7 HDGF MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B MIR6781 PSME3 BECN1 COA3 CNTD1 AOC2 AOC3 VPS25 RAMP2-AS1 RAMP2
GH17I042419 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 18.3 -402.4 -402441 5.2 PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B CAVIN1 LOC102725238 LINC00910 HMGN1P29 NBR2 ENSG00000267758 DHX58 PSME3 CNTD1 RETREG3
GH17I043366 Enhancer 1.5 Ensembl ENCODE dbSUPER 26.9 +544.3 544329 4 ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC LOC105371785 NBR2 DHX8 ASB16-AS1 HMGN1P29 LINC00910 TMUB2 UBTF ENSG00000267340 PSME3
GH17I043124 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 18.9 +301.2 301196 2.8 HDGF FOXA2 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 NBR2 PIR48082 PIR61659 BRCA1 DHX8 HMGN1P29 ENSG00000267758 LINC00910 PSME3 RND2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PSME3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PSME3 gene promoter:

Genomic Locations for PSME3 Gene

Genomic Locations for PSME3 Gene
chr17:42,824,385-42,843,760
(GRCh38/hg38)
Size:
19,376 bases
Orientation:
Plus strand
chr17:40,976,402-40,995,777
(GRCh37/hg19)

Genomic View for PSME3 Gene

Genes around PSME3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSME3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSME3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSME3 Gene

Proteins for PSME3 Gene

  • Protein details for PSME3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61289-PSME3_HUMAN
    Recommended name:
    Proteasome activator complex subunit 3
    Protein Accession:
    P61289
    Secondary Accessions:
    • A8K9A3
    • O35563
    • P97373
    • Q12920
    • Q13172
    • Q9BQD9

    Protein attributes for PSME3 Gene

    Size:
    254 amino acids
    Molecular mass:
    29506 Da
    Quaternary structure:
    • Homoheptamer; the stability of the heptamer is essential for the specific activation of the trypsine-like subunit and inhibition of the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits of the proteasome. Interacts with p53/TP53 and MDM2. Interacts with MAP3K3 (By similarity). Associates with the proteasome. Interacts with human cytomegalovirus UL27. Interacts with CCAR2.

    Alternative splice isoforms for PSME3 Gene

neXtProt entry for PSME3 Gene

Post-translational modifications for PSME3 Gene

  • Acetylation at the major site Lys-195 is important for oligomerization and ability to degrade its target substrates. Deacetylated by SIRT1.
  • Phosphorylated by MAP3K3 (By similarity). Phosphorylation at Ser-247 promotes its association with CCAR2.
  • Ubiquitination at isoforms=214, Lys37, Lys100, Lys110, Lys121, and Lys195

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PSME3 (PSME3)
  • Abcam antibodies for PSME3
  • Santa Cruz Biotechnology (SCBT) Antibodies for PSME3

Protein Products

  • Abcam proteins for PSME3

No data available for DME Specific Peptides for PSME3 Gene

Domains & Families for PSME3 Gene

Gene Families for PSME3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

P61289

UniProtKB/Swiss-Prot:

PSME3_HUMAN :
  • The C-terminal sequences affect heptamer stability and proteasome affinity.
  • Belongs to the PA28 family.
Domain:
  • The C-terminal sequences affect heptamer stability and proteasome affinity.
Family:
  • Belongs to the PA28 family.
genes like me logo Genes that share domains with PSME3: view

Function for PSME3 Gene

Molecular function for PSME3 Gene

GENATLAS Biochemistry:
proteasome (prosome,macropain) activator subunit 3 (PA28-gamma)
UniProtKB/Swiss-Prot Function:
Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (PubMed:25361978).
UniProtKB/Swiss-Prot Induction:
Up-regulated in thyroid carcinoma cells.

Phenotypes From GWAS Catalog for PSME3 Gene

Gene Ontology (GO) - Molecular Function for PSME3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IDA 18309296
GO:0005515 protein binding IPI 12970408
GO:0042802 identical protein binding IPI 16169070
GO:0061133 endopeptidase activator activity IDA 18309296
GO:0097371 MDM2/MDM4 family protein binding IDA 18309296
genes like me logo Genes that share ontologies with PSME3: view
genes like me logo Genes that share phenotypes with PSME3: view

Animal Models for PSME3 Gene

MGI Knock Outs for PSME3:

Animal Model Products

CRISPR Products

miRNA for PSME3 Gene

miRTarBase miRNAs that target PSME3

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PSME3 Gene

Localization for PSME3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSME3 Gene

Nucleus. Cytoplasm. Note=Localizes to the cytoplasm during mitosis following nuclear envelope breakdown at this distinct stage of the cell cycle which allows its interaction with MAP3K3 kinase. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSME3 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PSME3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex TAS 8811196
GO:0005634 nucleus IEA,HDA 21630459
GO:0005654 nucleoplasm IDA,TAS --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS,IDA --
genes like me logo Genes that share ontologies with PSME3: view

Pathways & Interactions for PSME3 Gene

SuperPathways for PSME3 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 HIV Life Cycle
.45
4 Class I MHC mediated antigen processing and presentation
5 Antigen processing-Cross presentation
genes like me logo Genes that share pathways with PSME3: view

Gene Ontology (GO) - Biological Process for PSME3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006521 regulation of cellular amino acid metabolic process TAS --
genes like me logo Genes that share ontologies with PSME3: view

No data available for SIGNOR curated interactions for PSME3 Gene

Drugs & Compounds for PSME3 Gene

(5) Drugs for PSME3 Gene - From: ApexBio and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 826
carfilzomib Approved, Investigational Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
AM 114 Pharma 20S proteasome inhibitor 0
CEP-18770 Pharma Proteasome inhibitor 0
MLN9708 Pharma Proteasome inhibitor, 20S Proteasome Inhibitor 0

(3) ApexBio Compounds for PSME3 Gene

Compound Action Cas Number
AM 114 20S proteasome inhibitor 856849-35-9
CEP-18770 Proteasome inhibitor 847499-27-8
MLN9708 Proteasome inhibitor 1201902-80-8
genes like me logo Genes that share compounds with PSME3: view

Drug Products

Transcripts for PSME3 Gene

Unigene Clusters for PSME3 Gene

Proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSME3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d
SP1: - -
SP2: - - - -
SP3: -
SP4: -
SP5: - - -
SP6: - - - - - -
SP7: - - - -
SP8: -
SP9: - - - - - - -
SP10:
SP11:

Relevant External Links for PSME3 Gene

GeneLoc Exon Structure for
PSME3
ECgene alternative splicing isoforms for
PSME3

Expression for PSME3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSME3 Gene

Protein differential expression in normal tissues from HIPED for PSME3 Gene

This gene is overexpressed in Bone (13.9) and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSME3 Gene



Protein tissue co-expression partners for PSME3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PSME3 Gene:

PSME3

SOURCE GeneReport for Unigene cluster for PSME3 Gene:

Hs.152978

Evidence on tissue expression from TISSUES for PSME3 Gene

  • Nervous system(5)
  • Lung(4.6)
  • Intestine(3.6)
  • Skin(3.4)
  • Eye(2.5)
  • Kidney(2.3)
  • Thyroid gland(2.3)
  • Liver(2)
genes like me logo Genes that share expression patterns with PSME3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSME3 Gene

Orthologs for PSME3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PSME3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSME3 33 34
  • 99.74 (n)
cow
(Bos Taurus)
Mammalia PSME3 33 34
  • 96.59 (n)
rat
(Rattus norvegicus)
Mammalia Psme3 33
  • 94.62 (n)
dog
(Canis familiaris)
Mammalia PSME3 33 34
  • 94.13 (n)
mouse
(Mus musculus)
Mammalia Psme3 33 16 34
  • 94.09 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PSME3 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves PSME3 33 34
  • 85.96 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 96 (a)
OneToMany
-- 34
  • 72 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia psme3 33
  • 77.3 (n)
Str.3210 33
zebrafish
(Danio rerio)
Actinopterygii psme3 33 34
  • 73.62 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10191 33
fruit fly
(Drosophila melanogaster)
Insecta REG 35 33 34
  • 54.95 (n)