PSME3 Gene(Protein Coding)

Proteasome Activator Subunit 3

GCID:: GC17P042824

GIFtS:: 49

Genes Participants

Aliases for PSME3 Gene

Proteasome Activator Subunit 3 ² ³ ⁵
Proteasome (Prosome, Macropain) Activator Subunit 3 (PA28 Gamma; Ki) ² ³
Activator Of Multicatalytic Protease Subunit 3 ³ ⁴
Proteasome Activator 28 Subunit Gamma ³ ⁴
11S Regulator Complex Subunit Gamma ³ ⁴
Ki Nuclear Autoantigen ³ ⁴
PA28gamma ³ ⁴
Proteasome Activator Complex Subunit 3 ³
11S Regulator Complex Gamma Subunit ³
Epididymis Secretory Protein Li 283 ³
Proteasome Activator 28-Gamma ³

PA28 Gamma Variant 5 ³
REG Gamma-3 ³
Ki Antigen ³
PA28-Gamma ³
HEL-S-283 ³
REG-GAMMA ³
REG-Gamma ⁴
PA28G ³
PA28g ⁴
Ki ³

External Ids for PSME3 Gene

HGNC: 9570
Entrez Gene: 10197
Ensembl: ENSG00000131467
OMIM: 605129
UniProtKB: P61289

Previous GeneCards Identifiers for PSME3 Gene

GC17M040635
GC17P043138
GC17P040885
GC17P041358
GC17P038238
GC17P040985
GC17P036749

Search aliases for PSME3 gene in PubMed and other databases

Summaries for PSME3 Gene

Entrez Gene Summary for PSME3 Gene

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

GeneCards Summary for PSME3 Gene

PSME3 (Proteasome Activator Subunit 3) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and RET signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding and MDM2/MDM4 family protein binding. An important paralog of this gene is PSME1.

UniProtKB/Swiss-Prot for PSME3 Gene

PSME3_HUMAN,P61289

Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (PubMed:25361978).

Gene Wiki entry for PSME3 Gene

Additional gene information for PSME3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSME3 Gene

Genomics for PSME3 Gene

GeneHancer (GH) Regulatory Elements for PSME3 Gene

Promoters and enhancers for PSME3 Gene

GeneHancer (GH) Identifier	GH Type	GH Score	GH Sources	Gene Association Score	Total Score	TSS distance (kb)	Number of Genes Away	Size (kb)	Transcription Factor Binding Sites
GH17J042832	Promoter/Enhancer	2.1	EPDnew Ensembl ENCODE	650.4	+9.3	9256	3.1	CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC	BECN1 PSME3 NKIRAS2 MEOX1 ENSG00000212149 PTGES3L-AARSD1 RPL27 CNTD1 COA3 STAT3
GH17J042823	Promoter/Enhancer	2	EPDnew Ensembl ENCODE	650.7	-0.3	-308	1.7	HDGF MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B	MIR6781 PSME3 BECN1 CNTD1 COA3 AOC2 AOC3 VPS25 RAMP2-AS1 RAMP2
GH17J043366	Enhancer	1.5	Ensembl ENCODE dbSUPER	37.3	+544.3	544329	4	ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC	LOC105371785 DHX8 NBR2 HMGN1P29 ASB16-AS1 LINC00910 TMUB2 UBTF PSME3 ENSG00000267340
GH17J042419	Promoter/Enhancer	2.5	EPDnew FANTOM5 Ensembl ENCODE dbSUPER	18.3	-402.4	-402441	5.2	PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B	CAVIN1 LOC102725238 LINC00910 HMGN1P29 NBR2 CNTD1 RETREG3 ENSG00000267758 ACLY DHX58
GH17J043124	Promoter/Enhancer	2.1	EPDnew Ensembl ENCODE	18.9	+301.2	301196	2.8	MLX DMAP1 YY1 E2F8 ZNF143 SP3 NFYC ZC3H11A ZNF610 GLIS1	NBR2 PIR48082 PIR61659 NBR1 BRCA1 DHX8 HMGN1P29 ENSG00000267758 LINC00910 RETREG3

- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSME3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PSME3 gene promoter:

AP-1
p53
GR
GR-alpha
GR-beta

Regulatory Element Products

Genomic Locations for PSME3 Gene

chr17:42,824,385-42,843,760: (GRCh38/hg38)

Size:: 19,376 bases
Orientation:: Plus strand

chr17:40,976,402-40,995,777: (GRCh37/hg19)

Size:: 19,376 bases
Orientation:: Plus strand

Genomic View for PSME3 Gene

Genes around PSME3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:

17q21.31 by Entrez Gene
17q21.31 by HGNC
17q21.31 by Ensembl

PSME3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

Genomic Location for PSME3 Gene — Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PSME3 Gene

NC_000017.11

Proteins for PSME3 Gene

Protein details for PSME3 Gene (UniProtKB/Swiss-Prot)
Protein Symbol:

P61289-PSME3_HUMAN

Recommended name:

Proteasome activator complex subunit 3

Protein Accession:

P61289

Secondary Accessions:
- A8K9A3
- O35563
- P97373
- Q12920
- Q13172
- Q9BQD9
Protein attributes for PSME3 Gene
Size:

254 amino acids

Molecular mass:

29506 Da
Quaternary structure:
Homoheptamer; the stability of the heptamer is essential for the specific activation of the trypsine-like subunit and inhibition of the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits of the proteasome. Interacts with p53/TP53 and MDM2. Interacts with MAP3K3 (By similarity). Associates with the proteasome. Interacts with human cytomegalovirus UL27. Interacts with CCAR2.
Alternative splice isoforms for PSME3 Gene
UniProtKB/Swiss-Prot:
P61289-1, Q12920-1

P61289-2, Q12920-2

P61289-3

neXtProt entry for PSME3 Gene

Protein Expression for PSME3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for PSME3 Gene

Phosphorylated by MAP3K3 (By similarity). Phosphorylation at Ser-247 promotes its association with CCAR2.
- P61289-PSME3_HUMAN
Acetylation at the major site Lys-195 is important for oligomerization and ability to degrade its target substrates. Deacetylated by SIRT1.
- P61289-PSME3_HUMAN
Ubiquitination at posLast=195195, Lys121, Lys110, Lys100, posLast=3737, and Lys14
- NX_P61289
Modification sites at PhosphoSitePlus
- P61289

Other Protein References for PSME3 Gene

ENSEMBL proteins:

REFSEQ proteins:

Antibody Products

Browse R&D Systems for Antibodies

OriGene Antibodies for PSME3
- TA308562
- TA326811
- TA339290
- TA339291
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Novus Biologicals Antibodies for PSME3

Abcam antibodies for PSME3
- PSME3

Invitrogen Antibodies for PSME3 (AFLGC-PSME3)

antibodies-online: Search results for 59 available PSME3 Antibodies ranked by validation data
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GeneTex PSME3 Antibody for PSME3

Biorbyt antibodies for PSME3
- orb340707
- orb238166
- orb129726
- orb330470
- orb228209
- orb4706
- orb7554
- orb447023
- orb480390
- orb496265
- orb238262
- orb238263
- orb238264

Boster Bio Antibodies for PSME3
- A04375
- A04375-1

Santa Cruz Biotechnology (SCBT) Antibodies for PSME3
- PA28γ (47)

Sino Biological Antibodies for PSME3

Protein Products

R&D Systems Proteins and Enzymes for PSME3 (PA28 Activator gamma Subunit)

OriGene Purified Proteins for PSME3
Search Origene for MassSpec and Protein Over-expression Lysates for PSME3
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Novus Biologicals proteins and lysates for PSME3

Sino Biological Recombinant Proteins for PSME3
Browse Sino Biological Cell Lysates

ProSpec Recombinant Proteins for PSME3

antibodies-online: Search results for 15 available PSME3 Proteins ranked by validation data
Compare Top PSME3 Proteins

Search GeneTex for Proteins for PSME3

ProSci Proteins for PSME3
- proteasome activator subunit 3

Abcam proteins for PSME3
- PSME3

Assay Products

Browse R&D Systems for biochemical assays

GenScript Custom Assay Services for PSME3

antibodies-online: Search results for 7 available PSME3 Elisa Kits ranked by validation data
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No data available for DME Specific Peptides for PSME3 Gene

Domains & Families for PSME3 Gene

Gene Families for PSME3 Gene

HGNC:

690 : Proteasome

Human Protein Atlas (HPA):

Predicted intracellular proteins

Protein Domains for PSME3 Gene

Blocks:

Proteasome activator pa28, alpha subunit

InterPro:

ProtoNet:

P61289

Suggested Antigen Peptide Sequences for PSME3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P61289

UniProtKB/Swiss-Prot:

PSME3_HUMAN :

The C-terminal sequences affect heptamer stability and proteasome affinity.
Belongs to the PA28 family.

Domain:

The C-terminal sequences affect heptamer stability and proteasome affinity.

Family:

Belongs to the PA28 family.

Function for PSME3 Gene

Molecular function for PSME3 Gene

UniProtKB/Swiss-Prot Function:

Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (PubMed:25361978).

PSME3_HUMAN,P61289

UniProtKB/Swiss-Prot Induction:

Up-regulated in thyroid carcinoma cells.

PSME3_HUMAN,P61289

GENATLAS Biochemistry:

proteasome (prosome,macropain) activator subunit 3 (PA28-gamma)

PSME3

Phenotypes From GWAS Catalog for PSME3 Gene

Gene Ontology (GO) - Molecular Function for PSME3 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002039	p53 binding	IDA	18309296
GO:0005515	protein binding	IPI	12970408
GO:0042802	identical protein binding	IPI	16169070
GO:0061133	endopeptidase activator activity	IDA	18309296
GO:0097371	MDM2/MDM4 family protein binding	IDA	18309296

Phenotypes for PSME3 Gene

MGI mutant phenotypes for PSME3:

inferred from 2 alleles

GenomeRNAi human phenotypes for PSME3:

Animal Models for PSME3 Gene

MGI Knock Outs for PSME3:

Psme3 ^{Psme3<tm1Jjm>}
Psme3 ^{Psme3<tm1Tchi>}

Animal Model Products

Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study

Cyagen custom Knockout/knockin (KOKI) mouse models for PSME3
Cyagen custom CRISPR mouse and rat models for PSME3
- CRISPR mouse model (ROSA26 knockin) rat model (ROSA26 knockin)
Cyagen custom transgenic mouse and rat models for PSME3
- PiggyBac transgenic mouse and rat models

CRISPR Products

OriGene CRISPR knockouts for PSME3
- KN400308
- KN514131

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genomics-online: gRNA clones - Search results for available PSME3 gene related products

Applied Biological Materials CRISPR for PSME3
Vectors and viruses for KO, Activation, Repression, and more
- PSME3-CRISPR-CAS9-Knockout

Santa Cruz Biotechnology (SCBT) CRISPR for PSME3

GenScript: Design CRISPR guide RNA sequences for PSME3

miRNA for PSME3 Gene

miRTarBase miRNAs that target PSME3

miRNA Products

GeneCopoeia miRNA 3'UTR Target clone products for PSME3

SwitchGear PSME3 3' UTR sequence
Browse SwitchGear 3'UTR luciferase reporter plasmids

Browse OriGene miRNA Products For PSME3

Inhibitory RNA Products

Origene shrna, sirna, and RNAi products in human, mouse, rat for PSME3
Browse OriGene Inhibitory RNA Products For PSME3

Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSME3

genomics-online: shRNA clones - Search results for available PSME3 gene related products

Search Santa Cruz Biotechnology (SCBT) for PSME3 siRNA/shRNA

Clone Products

OriGene clones in human for PSME3
- SC107168
- SC310584
- SC321554
- SC330746
OriGene ORF clones in human for PSME3
- RC200308
- RC200308L1
- RC200308L2
- RC200308L3
- RC200308L4
- RC222312
- RC222312L1
- RC222312L2
- RC222312L3
- RC222312L4
- RC232329
- RC500308
- RG200308
- RG222312
- RG232329
- RC200308L1V
- RC200308L2V
- RC200308L3V
- RC200308L4V
- RC222312L1V
- RC222312L2V
- RC222312L3V
- RC222312L4V
Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling

GenScript: Next-day shipping of latest version cDNA ORF clones for PSME3 in any vector

Sino Biological Human cDNA Clone for PSME3

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genomics-online: cdna clones - Search results for available PSME3 gene related products
orf clones - Search results for available PSME3 gene related products

Applied Biological Materials Clones for PSME3
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- PSME3

Cell Line Products

GenScript Custom overexpressing Cell Line Services for PSME3

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Horizon Cell Lines for PSME3
- PSME3 knockout cell line

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PSME3 Gene

Localization for PSME3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSME3 Gene

Nucleus. Cytoplasm. Note=Localizes to the cytoplasm during mitosis following nuclear envelope breakdown at this distinct stage of the cell cycle which allows its interaction with MAP3K3 kinase. {ECO:0000250}.

P61289-PSME3_HUMAN

Subcellular locations from

COMPARTMENTS

Compartment	Confidence
nucleus	5
cytosol	5
mitochondrion	1

Subcellular locations from the

Human Protein Atlas (HPA)

Nucleoplasm (4)

See all subcellular structures

Gene Ontology (GO) - Cellular Components for PSME3 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000502	proteasome complex	TAS	8811196
GO:0005634	nucleus	IEA,HDA	21630459
GO:0005654	nucleoplasm	IDA,TAS	--
GO:0005737	cytoplasm	IBA	--
GO:0005829	cytosol	TAS,IDA	--

Pathways & Interactions for PSME3 Gene

SuperPathways for PSME3 Gene

More details on SuperPathways for PSME3

	SuperPathway	Contained pathways
1	CDK-mediated phosphorylation and removal of Cdc6	Activation of APC/C and APC/C-Cdc20 mediated degradation of mitotic proteins .95 Cdc20-Phospho-APC/C mediated degradation of Cyclin A .95 Autodegradation of the E3 ubiquitin ligase COP1 .95 Stabilization of p53 .95 Regulation of activated PAK-2p34 by proteasome mediated degradation .94 Regulation of Apoptosis .94 CDK-mediated phosphorylation and removal of Cdc6 .94 Ubiquitin-dependent degradation of Cyclin D .94 Ubiquitin-dependent degradation of Cyclin D1 .94 Orc1 removal from chromatin .94 Regulation of DNA replication .94 Switching of origins to a post-replicative state .94 Cyclin A-Cdk2-associated events at S phase entry .93 Cyclin E associated events during G1/S transition .93 APC/C-Cdc20 mediated degradation of Securin .93 APC/C-Cdh1 mediated degradation of Cdc20 and other APC/C-Cdh1 targeted proteins in late mitosis/early G1 .93 APC/C-mediated degradation of cell cycle proteins .93 Regulation of APC/C activators between G1/S and early anaphase .93 Regulation of mitotic cell cycle .93 DNA Replication .93 Synthesis of DNA .93 Vpu mediated degradation of CD4 .93 Autodegradation of Cdh1 by Cdh1-APC/C .91 SCF-beta-TrCP mediated degradation of Emi1 .91 p53-Independent DNA Damage Response .91 p53-Independent G1/S DNA damage checkpoint .91 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A .91 ABC transporter disorders .91 Disorders of transmembrane transporters .91 Defective CFTR causes cystic fibrosis .90 Assembly of the pre-replicative complex .90 Hedgehog ligand biogenesis .90 Hh mutants abrogate ligand secretion .90 APC/C-Cdc20 mediated degradation of mitotic proteins .89 APC-Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint .89 Vif-mediated degradation of APOBEC3G .89 Degradation of GLI1 by the proteasome .89 Degradation of GLI2 by the proteasome .89 GLI3 is processed to GLI3R by the proteasome .89	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis .88 Degradation of AXIN .88 Cellular response to hypoxia .87 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha .87 Regulation of Hypoxia-inducible Factor (HIF) by oxygen .87 CDT1 association with the CDC6-ORC-origin complex .87 Hh mutants that dont undergo autocatalytic processing are degraded by ERAD .87 AUF1 (hnRNP D0) binds and destabilizes mRNA .86 p53-Dependent G1 DNA Damage Response .86 p53-Dependent G1/S DNA damage checkpoint .86 SCF(Skp2)-mediated degradation of p27/p21 .86 Removal of licensing factors from origins .86 NIK-->noncanonical NF-kB signaling .85 Dectin-1 mediated noncanonical NF-kB signaling .84 G1/S DNA Damage Checkpoints .84 Degradation of DVL .83 Cross-presentation of soluble exogenous antigens (endosomes) .82 The role of GTSE1 in G2/M progression after G2 checkpoint .81 Regulation of ornithine decarboxylase (ODC) .81 DNA Replication Pre-Initiation .80 M/G1 Transition .80 Proteasome .78 S Phase .78 Activation of NF-kappaB in B cells .77 Asymmetric localization of PCP proteins .74 FCERI mediated NF-kB activation .72 Regulation of RAS by GAPs .70 PCP/CE pathway .70 Beta-catenin independent WNT signaling .64 Degradation of beta-catenin by the destruction complex .64 Regulation of mRNA stability by proteins that bind AU-rich elements .63 Metabolism of polyamines .60 TNFR2 non-canonical NF-kB pathway .58 ABC-family proteins mediated transport .57 MAPK6/MAPK4 signaling .57 Proteasome Degradation .56 UCH proteinases .47 Apoptosis .31 Programmed Cell Death .31
2	RET signaling	Frs2-mediated activation .95 GRB2 events in EGFR signaling .95 MAPK1/MAPK3 signaling .95 Prolonged ERK activation events .95 RAF/MAP kinase cascade .95 SHC1 events in EGFR signaling .95 Signaling by Leptin .95 SOS-mediated signalling .95 VEGFR2 mediated cell proliferation .95 ARMS-mediated activation .95 Signalling to ERKs .95 Signalling to p38 via RIT and RIN .95 Signalling to RAS .95 Interleukin receptor SHC signaling .95 Interleukin-3, 5 and GM-CSF signaling .94 Interleukin-2 signaling .94 Downstream signal transduction .94 Signaling by PDGF .94 DAP12 signaling .92	RET signaling .92 Insulin receptor signalling cascade .92 Signaling by Insulin receptor .92 IRS-mediated signalling .91 Signaling by EGFR .90 FCERI mediated MAPK activation .90 IGF1R signaling cascade .90 IRS-related events triggered by IGF1R .90 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) .90 DAP12 interactions .89 NCAM signaling for neurite out-growth .89 NGF signalling via TRKA from the plasma membrane .87 MAPK family signaling cascades .87 Signaling by SCF-KIT .85 Signalling by NGF .81 Fc epsilon receptor (FCERI) signaling .79 VEGFA-VEGFR2 Pathway .78 Signaling by VEGF .76 Gastrin-CREB signalling pathway via PKC and MAPK .55
3	HIV Life Cycle	HIV Infection .64 Infectious disease .61 Host Interactions of HIV factors .57	Disease .45 Diseases of signal transduction .43
4	Class I MHC mediated antigen processing and presentation	Antigen processing- Ubiquitination and Proteasome degradation .83 Class I MHC mediated antigen processing and presentation .83	Adaptive Immune System .45
5	Antigen processing-Cross presentation	Antigen processing-Cross presentation .84 ER-Phagosome pathway .84	Immune response Antigen presentation by MHC class I .51

Pathways by source for PSME3 Gene

1 BioSystems pathway for PSME3 Gene

Proteasome Degradation

164 Reactome pathways for PSME3 Gene

3 KEGG pathways for PSME3 Gene

1 GeneGo (Thomson Reuters) pathway for PSME3 Gene

Immune response Antigen presentation by MHC class I

Interacting Proteins for PSME3 Gene

http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000293362%0d%0a9606.ENSP00000227507%0d%0a9606.ENSP00000345405%0d%0a9606.ENSP00000360621%0d%0a9606.ENSP00000394394%0d%0a9606.ENSP00000363322%0d%0a — STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins: P61289-PSME3_HUMAN ENSP00000293362 for PSME3 Gene via UniProtKB STRING MINT IID

Symbol	External ID(s)	Details
TP53	P04637 ¹⁹ ⁴ ¹³⁷ ENSP00000269305 ²⁰	MINT-6540940 MINT-6540866 MINT-6540807 MINT-6540776 MINT-6540960 MINT-6541016 MINT-6540876 EBI-355546, EBI-366083 STRING: ENSP00000269305 IID: # exp=2 # pred=1
SMURF1	Q9HCE7 ¹⁹ ⁴ ¹³⁷ ENSP00000354621 ²⁰	MINT-7894558 MINT-7894523 MINT-7894494 MINT-7894543 MINT-7894481 EBI-355546, EBI-976466 STRING: ENSP00000354621 IID: # exp=1 # pred=1
EAF1	Q96JC9 ¹⁹ ⁴ ¹³⁷ ENSP00000380054 ²⁰	MINT-8169842 EBI-355546, EBI-769261 STRING: ENSP00000380054 IID: # exp=2
EAF2	Q96CJ1 ¹⁹ ⁴ ¹³⁷ ENSP00000273668 ²⁰	MINT-8166269 EBI-355546, EBI-1245604 STRING: ENSP00000273668 IID: # exp=1
MDM2	Q00987 ¹⁹ ⁴ ¹³⁷	MINT-6540920 MINT-6540985 MINT-6540796 MINT-6540998 MINT-6540973 MINT-6540807 MINT-6540837 MINT-6540853 EBI-355546, EBI-389668 IID: # exp=2 # pred=1

GPS-Prot Interaction Network for PSME3

Gene Ontology (GO) - Biological Process for PSME3 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000165	MAPK cascade	TAS	--
GO:0000209	protein polyubiquitination	TAS	--
GO:0002223	stimulatory C-type lectin receptor signaling pathway	TAS	--
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	TAS	--
GO:0006521	regulation of cellular amino acid metabolic process	TAS	--

No data available for SIGNOR curated interactions for PSME3 Gene

Drugs & Compounds for PSME3 Gene

(5) Drugs for PSME3 Gene - From: DGIdb

Name	Status	Disease Links	Group	Role	Mechanism of Action	Clinical Trials
Bortezomib	Approved, Investigational	MalaCards Medline Plus	Pharma	inhibitor, other	Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors	826
carfilzomib	Approved, Investigational	MalaCards Medline Plus	Pharma	other, Inhibitor	Other, 20S Proteasome Inhibitor	0
AM 114		MalaCards Medline Plus	Pharma		20S proteasome inhibitor	0
CEP-18770		MalaCards Medline Plus	Pharma		Proteasome inhibitor	0
MLN9708		MalaCards Medline Plus	Pharma		Proteasome inhibitor, 20S Proteasome Inhibitor	0

Drug Products

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Transcripts for PSME3 Gene

mRNA/cDNA for PSME3 Gene

(4) REFSEQ mRNAs :

(15) Additional mRNA sequences :

(626) Selected AceView cDNA sequences:

(17) Ensembl transcripts including schematic representations, and UCSC links where relevant :