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Aliases for PSME2 Gene

Aliases for PSME2 Gene

  • Proteasome Activator Subunit 2 2 3 5
  • Proteasome (Prosome, Macropain) Activator Subunit 2 (PA28 Beta) 2 3
  • Activator Of Multicatalytic Protease Subunit 2 3 4
  • Proteasome Activator 28 Subunit Beta 3 4
  • 11S Regulator Complex Subunit Beta 3 4
  • PA28beta 3 4
  • REG-Beta 3 4
  • Proteasome Activator HPA28 Subunit Beta 3
  • Proteasome Activator Complex Subunit 2 3
  • 11S Regulator Complex Beta Subunit 3
  • Cell Migration-Inducing Protein 22 3
  • MCP Activator, 31-KD Subunit 3
  • Proteasome Activator 28-Beta 3
  • REGbeta 3
  • PA28B 3
  • PA28b 4

External Ids for PSME2 Gene

Previous GeneCards Identifiers for PSME2 Gene

  • GC14M021985
  • GC14M018399
  • GC14M022602
  • GC14M023677
  • GC14M024612
  • GC14M004727

Summaries for PSME2 Gene

Entrez Gene Summary for PSME2 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13. [provided by RefSeq, Jul 2008]

GeneCards Summary for PSME2 Gene

PSME2 (Proteasome Activator Subunit 2) is a Protein Coding gene. Diseases associated with PSME2 include Ulceroglandular Tularemia. Among its related pathways are Cell Cycle, Mitotic and RET signaling. An important paralog of this gene is PSME1.

UniProtKB/Swiss-Prot for PSME2 Gene

  • Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.

Gene Wiki entry for PSME2 Gene

Additional gene information for PSME2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSME2 Gene

Genomics for PSME2 Gene

GeneHancer (GH) Regulatory Elements for PSME2 Gene

Promoters and enhancers for PSME2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J024144 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.7 719 3.7 HDGF PKNOX1 CLOCK SMAD1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 RNF31 PSME2 EMC9
GH14J024194 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 20.6 -48.3 -48307 3.5 HDGF PKNOX1 CLOCK MLX ZFP64 ARID4B SIN3A DMAP1 IRF4 YY1 TM9SF1 PIR45873 RNF31 PABPN1 NGDN TINF2 TSSK4 RNA5SP383 MDP1 SLC22A17
GH14J024113 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11 +32.7 32730 3.1 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 SP3 DCAF11 NRL RNF31 KHNYN RNA5SP383 IPO4 TM9SF1 TINF2 TSSK4 NFATC4
GH14J023297 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.7 +846.9 846870 5.5 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 HOMEZ BCL2L2 PPP1R3E PIR57322 ACIN1 RNF31 RNA5SP383 PRMT5 RBM23 LOC102724814
GH14J024080 Promoter/Enhancer 1.5 Ensembl ENCODE 10.7 +66.1 66130 1.8 ATF1 ARNT ARID4B SIN3A DMAP1 ZNF48 SLC30A9 GLIS2 KLF7 ATF7 NGDN CARMIL3 PABPN1 ACIN1 NYNRIN SDR39U1 PSME2 RNF31 IPO4 TM9SF1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PSME2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PSME2 gene promoter:

Genomic Locations for PSME2 Gene

Genomic Locations for PSME2 Gene
chr14:24,143,362-24,147,570
(GRCh38/hg38)
Size:
4,209 bases
Orientation:
Minus strand
chr14:24,612,574-24,616,779
(GRCh37/hg19)

Genomic View for PSME2 Gene

Genes around PSME2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSME2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSME2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSME2 Gene

Proteins for PSME2 Gene

  • Protein details for PSME2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL46-PSME2_HUMAN
    Recommended name:
    Proteasome activator complex subunit 2
    Protein Accession:
    Q9UL46
    Secondary Accessions:
    • Q15129

    Protein attributes for PSME2 Gene

    Size:
    239 amino acids
    Molecular mass:
    27402 Da
    Quaternary structure:
    • Heterodimer of PSME1 and PSME2, which forms a hexameric ring.

neXtProt entry for PSME2 Gene

Post-translational modifications for PSME2 Gene

  • Ubiquitination at posLast=145145, posLast=3939, and Lys15
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PSME2 Gene

Domains & Families for PSME2 Gene

Gene Families for PSME2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PSME2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UL46

UniProtKB/Swiss-Prot:

PSME2_HUMAN :
  • Belongs to the PA28 family.
Family:
  • Belongs to the PA28 family.
genes like me logo Genes that share domains with PSME2: view

Function for PSME2 Gene

Molecular function for PSME2 Gene

UniProtKB/Swiss-Prot Function:
Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.
UniProtKB/Swiss-Prot Induction:
By IFNG/IFN-gamma.
GENATLAS Biochemistry:
multicatalytic proteinase complex (prosome,macropain,20S),proteasome activator PA28 beta,homologous to Ki antigen,stimulated by interferon gamma,tightly linked to PSME1

Phenotypes From GWAS Catalog for PSME2 Gene

Gene Ontology (GO) - Molecular Function for PSME2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0042802 identical protein binding IPI 16189514
GO:0061133 endopeptidase activator activity IBA --
genes like me logo Genes that share ontologies with PSME2: view
genes like me logo Genes that share phenotypes with PSME2: view

Animal Models for PSME2 Gene

MGI Knock Outs for PSME2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSME2

Clone Products

  • Addgene plasmids for PSME2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PSME2 Gene

Localization for PSME2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSME2 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PSME2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex TAS 8811196
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0008537 proteasome activator complex IEA --
genes like me logo Genes that share ontologies with PSME2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PSME2 Gene

Pathways & Interactions for PSME2 Gene

SuperPathways for PSME2 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 HIV Life Cycle
.45
4 Class I MHC mediated antigen processing and presentation
5 Antigen processing-Cross presentation
genes like me logo Genes that share pathways with PSME2: view

Gene Ontology (GO) - Biological Process for PSME2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006521 regulation of cellular amino acid metabolic process TAS --
genes like me logo Genes that share ontologies with PSME2: view

No data available for SIGNOR curated interactions for PSME2 Gene

Drugs & Compounds for PSME2 Gene

(2) Drugs for PSME2 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 826
carfilzomib Approved, Investigational Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
genes like me logo Genes that share compounds with PSME2: view

Transcripts for PSME2 Gene

mRNA/cDNA for PSME2 Gene

Unigene Clusters for PSME2 Gene

Proteasome (prosome, macropain) activator subunit 2 (PA28 beta):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSME2

Clone Products

  • Addgene plasmids for PSME2

Alternative Splicing Database (ASD) splice patterns (SP) for PSME2 Gene

No ASD Table

Relevant External Links for PSME2 Gene

GeneLoc Exon Structure for
PSME2
ECgene alternative splicing isoforms for
PSME2

Expression for PSME2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSME2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PSME2 Gene

This gene is overexpressed in Liver, secretome (8.8) and Lymph node (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSME2 Gene



Protein tissue co-expression partners for PSME2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PSME2 Gene:

PSME2

SOURCE GeneReport for Unigene cluster for PSME2 Gene:

Hs.434081

Evidence on tissue expression from TISSUES for PSME2 Gene

  • Liver(4.5)
  • Pancreas(4.2)
  • Lung(3.3)
  • Nervous system(3.3)
  • Spleen(2.5)
  • Blood(2.3)
  • Lymph node(2.3)
  • Kidney(2)
genes like me logo Genes that share expression patterns with PSME2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSME2 Gene

Orthologs for PSME2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PSME2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSME2 34 33
  • 99.58 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Psme2b 34
  • 94 (a)
OneToMany
Psme2 16 34 33
  • 90.66 (n)
dog
(Canis familiaris)
Mammalia PSME2 34 33
  • 93.58 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PSME2 34 33
  • 92.89 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psme2 33
  • 91.18 (n)
oppossum
(Monodelphis domestica)
Mammalia PSME2 34
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSME2 34
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSME2 34
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psme2 33
  • 61.06 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.17544 33
zebrafish
(Danio rerio)
Actinopterygii psme2 34 33 33
  • 63.46 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8328 33
fruit fly
(Drosophila melanogaster)
Insecta REG 34
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y66D12A.9 34
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 30 (a)
ManyToMany
-- 34
  • 29 (a)
ManyToMany
-- 34
  • 29 (a)
ManyToMany
Species where no ortholog for PSME2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSME2 Gene

ENSEMBL:
Gene Tree for PSME2 (if available)
TreeFam:
Gene Tree for PSME2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PSME2: view image

Paralogs for PSME2 Gene

Paralogs for PSME2 Gene

(2) SIMAP similar genes for PSME2 Gene using alignment to 7 proteins:

  • PSME2_HUMAN
  • H0YKU2_HUMAN
  • H0YLD2_HUMAN
  • H0YLG1_HUMAN
  • H0YM70_HUMAN
  • Q6FHK9_HUMAN
  • Q86SZ7_HUMAN
genes like me logo Genes that share paralogs with PSME2: view

Variants for PSME2 Gene

Sequence variations from dbSNP and Humsavar for PSME2 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs794729666 uncertain-significance, not provided 24,147,998(-) T/C upstream_transcript_variant
rs1000727801 -- 24,146,254(-) A/G intron_variant
rs1000829856 -- 24,143,826(-) T/C intron_variant
rs1000965185 -- 24,143,489(-) C/T coding_sequence_variant, missense_variant
rs1001574712 -- 24,147,343(-) G/C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PSME2 Gene

Variant ID Type Subtype PubMed ID
nsv564057 CNV loss 21841781
nsv974317 CNV duplication 23825009

Variation tolerance for PSME2 Gene

Residual Variation Intolerance Score: 67.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PSME2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSME2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSME2 Gene

Disorders for PSME2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PSME2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ulceroglandular tularemia
- elite association - COSMIC cancer census association via MalaCards
Search PSME2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PSME2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PSME2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSME2 Gene

Publications for PSME2 Gene

  1. Primary structures of two homologous subunits of PA28, a gamma-interferon-inducible protein activator of the 20S proteasome. (PMID: 7789512) Ahn JY … Mott JD (FEBS letters 1995) 2 3 4 58
  2. Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X … Huang L (Biochemistry 2007) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Impaired expression of proteasome subunits and human leukocyte antigens class I in human colon cancer cells. (PMID: 12519221) Miyagi T … Hayashi N (Journal of gastroenterology and hepatology 2003) 3 22 58
  5. Organization of the genes encoding the human proteasome activators PA28alpha and beta. (PMID: 10199920) McCusker D … Trowsdale J (Immunogenetics 1999) 3 4 58

Products for PSME2 Gene

  • Addgene plasmids for PSME2
  • GeneTex