The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 n... See more...

Aliases for PSME2 Gene

Aliases for PSME2 Gene

  • Proteasome Activator Subunit 2 2 3 5
  • PA28beta 2 3 4
  • Proteasome (Prosome, Macropain) Activator Subunit 2 (PA28 Beta) 2 3
  • Activator Of Multicatalytic Protease Subunit 2 3 4
  • Proteasome Activator Complex Subunit 2 3 4
  • Proteasome Activator 28 Subunit Beta 3 4
  • 11S Regulator Complex Subunit Beta 3 4
  • REG-Beta 3 4
  • Proteasome Activator HPA28 Subunit Beta 3
  • 11S Regulator Complex Beta Subunit 3
  • Cell Migration-Inducing Protein 22 3
  • MCP Activator, 31-KD Subunit 3
  • Proteasome Activator 28-Beta 3
  • REGbeta 3
  • PA28B 3
  • PSME2 5
  • PA28b 4

External Ids for PSME2 Gene

Previous GeneCards Identifiers for PSME2 Gene

  • GC14M021985
  • GC14M018399
  • GC14M022602
  • GC14M023677
  • GC14M024612
  • GC14M004727

Summaries for PSME2 Gene

Entrez Gene Summary for PSME2 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13. [provided by RefSeq, Jul 2008]

GeneCards Summary for PSME2 Gene

PSME2 (Proteasome Activator Subunit 2) is a Protein Coding gene. Diseases associated with PSME2 include Immunodeficiency 12 and Ulceroglandular Tularemia. Among its related pathways are Downstream signaling events of B Cell Receptor (BCR) and CDK-mediated phosphorylation and removal of Cdc6. An important paralog of this gene is PSME1.

UniProtKB/Swiss-Prot Summary for PSME2 Gene

  • Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.

Gene Wiki entry for PSME2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSME2 Gene

Genomics for PSME2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PSME2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSME2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PSME2

Top Transcription factor binding sites by QIAGEN in the PSME2 gene promoter:
  • AML1a
  • STAT3

Genomic Locations for PSME2 Gene

Latest Assembly
chr14:24,143,362-24,147,570
(GRCh38/hg38)
Size:
4,209 bases
Orientation:
Minus strand

Previous Assembly
chr14:24,612,574-24,615,819
(GRCh37/hg19 by Entrez Gene)
Size:
3,246 bases
Orientation:
Minus strand

chr14:24,612,574-24,616,779
(GRCh37/hg19 by Ensembl)
Size:
4,206 bases
Orientation:
Minus strand

Genomic View for PSME2 Gene

Genes around PSME2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSME2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSME2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSME2 Gene

Proteins for PSME2 Gene

  • Protein details for PSME2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL46-PSME2_HUMAN
    Recommended name:
    Proteasome activator complex subunit 2
    Protein Accession:
    Q9UL46
    Secondary Accessions:
    • Q15129

    Protein attributes for PSME2 Gene

    Size:
    239 amino acids
    Molecular mass:
    27402 Da
    Quaternary structure:
    • Heterodimer of PSME1 and PSME2, which forms a hexameric ring.

neXtProt entry for PSME2 Gene

Post-translational modifications for PSME2 Gene

  • Ubiquitination at Lys15, Lys39, and Lys145
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PSME2 Gene

Domains & Families for PSME2 Gene

Gene Families for PSME2 Gene

Protein Domains for PSME2 Gene

InterPro:
Blocks:
  • Proteasome activator pa28, alpha subunit
ProtoNet:

Suggested Antigen Peptide Sequences for PSME2 Gene

GenScript: Design optimal peptide antigens:
  • Proteasome activator 28 subunit beta (PSME2_HUMAN)
  • PSME2 protein (Q6FHK9_HUMAN)
  • PSME2 protein (Q86SZ7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UL46

UniProtKB/Swiss-Prot:

PSME2_HUMAN :
  • Belongs to the PA28 family.
Family:
  • Belongs to the PA28 family.
genes like me logo Genes that share domains with PSME2: view

Function for PSME2 Gene

Molecular function for PSME2 Gene

UniProtKB/Swiss-Prot Function:
Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.
UniProtKB/Swiss-Prot Induction:
By IFNG/IFN-gamma.
GENATLAS Biochemistry:
multicatalytic proteinase complex (prosome,macropain,20S),proteasome activator PA28 beta,homologous to Ki antigen,stimulated by interferon gamma,tightly linked to PSME1

Phenotypes From GWAS Catalog for PSME2 Gene

Gene Ontology (GO) - Molecular Function for PSME2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0042802 identical protein binding IPI 16189514
GO:0061133 endopeptidase activator activity IBA 21873635
genes like me logo Genes that share ontologies with PSME2: view
genes like me logo Genes that share phenotypes with PSME2: view

Animal Models for PSME2 Gene

MGI Knock Outs for PSME2:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSME2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PSME2 Gene

Localization for PSME2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSME2 gene
Compartment Confidence
cytosol 5
extracellular 4
nucleus 4
mitochondrion 2
plasma membrane 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PSME2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IEA,TAS 8811196
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
GO:0008537 proteasome activator complex IEA --
genes like me logo Genes that share ontologies with PSME2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PSME2 Gene

Pathways & Interactions for PSME2 Gene

PathCards logo

SuperPathways for PSME2 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 HIV Life Cycle
.45
4 Class I MHC mediated antigen processing and presentation
5 Antigen processing-Cross presentation
.51
genes like me logo Genes that share pathways with PSME2: view

Pathways by source for PSME2 Gene

2 KEGG pathways for PSME2 Gene
1 GeneGo (Thomson Reuters) pathway for PSME2 Gene
  • Immune response Antigen presentation by MHC class I

Gene Ontology (GO) - Biological Process for PSME2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006521 regulation of cellular amino acid metabolic process TAS --
genes like me logo Genes that share ontologies with PSME2: view

No data available for SIGNOR curated interactions for PSME2 Gene

Drugs & Compounds for PSME2 Gene

(2) Drugs for PSME2 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 926
carfilzomib Approved, Investigational Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
genes like me logo Genes that share compounds with PSME2: view

Transcripts for PSME2 Gene

mRNA/cDNA for PSME2 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
18 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSME2

Alternative Splicing Database (ASD) splice patterns (SP) for PSME2 Gene

No ASD Table

Relevant External Links for PSME2 Gene

GeneLoc Exon Structure for
PSME2

Expression for PSME2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PSME2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PSME2 Gene

This gene is overexpressed in Liver, secretome (8.8) and Lymph node (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSME2 Gene



Protein tissue co-expression partners for PSME2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PSME2

SOURCE GeneReport for Unigene cluster for PSME2 Gene:

Hs.434081

Evidence on tissue expression from TISSUES for PSME2 Gene

  • Liver(4.6)
  • Pancreas(4.2)
  • Nervous system(3.7)
  • Lung(3.6)
  • Spleen(2.7)
  • Lymph node(2.7)
  • Blood(2.7)
  • Intestine(2.6)
  • Skin(2.5)
  • Heart(2.4)
  • Kidney(2.4)
  • Muscle(2.2)
  • Adrenal gland(2.2)
  • Bone marrow(2.1)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with PSME2: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSME2 Gene

Orthologs for PSME2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PSME2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PSME2 30 31
  • 99.58 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Psme2b 31
  • 94 (a)
OneToMany
Psme2 30 17 31
  • 90.66 (n)
OneToMany
Dog
(Canis familiaris)
Mammalia PSME2 30 31
  • 93.58 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PSME2 30 31
  • 92.89 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Psme2 30
  • 91.18 (n)
Oppossum
(Monodelphis domestica)
Mammalia PSME2 31
  • 88 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PSME2 31
  • 72 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PSME2 31
  • 72 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia psme2 30
  • 61.06 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.17544 30
Zebrafish
(Danio rerio)
Actinopterygii psme2 30 31
  • 63.46 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8328 30
Fruit Fly
(Drosophila melanogaster)
Insecta REG 31
  • 30 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea Y66D12A.9 31
  • 30 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 30 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
Species where no ortholog for PSME2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)