Aliases for PSME2 Gene
- Proteasome Activator Subunit 2 2 3 5
- PA28beta 2 3 4
- Proteasome (Prosome, Macropain) Activator Subunit 2 (PA28 Beta) 2 3
- Activator Of Multicatalytic Protease Subunit 2 3 4
- Proteasome Activator Complex Subunit 2 3 4
- Proteasome Activator 28 Subunit Beta 3 4
- 11S Regulator Complex Subunit Beta 3 4
- REG-Beta 3 4
External Ids for PSME2 Gene
Previous GeneCards Identifiers for PSME2 Gene
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13. [provided by RefSeq, Jul 2008]
GeneCards Summary for PSME2 Gene
PSME2 (Proteasome Activator Subunit 2) is a Protein Coding gene. Diseases associated with PSME2 include Immunodeficiency 12 and Ulceroglandular Tularemia. Among its related pathways are Downstream signaling events of B Cell Receptor (BCR) and CDK-mediated phosphorylation and removal of Cdc6. An important paralog of this gene is PSME1.
UniProtKB/Swiss-Prot Summary for PSME2 Gene
Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.