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Aliases for PSME1 Gene

Aliases for PSME1 Gene

  • Proteasome Activator Subunit 1 2 3 5
  • Proteasome (Prosome, Macropain) Activator Subunit 1 (PA28 Alpha) 2 3
  • Activator Of Multicatalytic Protease Subunit 1 3 4
  • Interferon Gamma Up-Regulated I-5111 Protein 3 4
  • 11S Regulator Complex Subunit Alpha 3 4
  • IGUP I-5111 3 4
  • PA28alpha 3 4
  • IFI5111 3 4
  • Epididymis Secretory Sperm Binding Protein Li 129m 3
  • Interferon-Gamma-Inducible Protein 5111 3
  • Proteasome Activator Complex Subunit 1 3
  • Proteasome Activator 28 Subunit Alpha 4
  • Interferon-Gamma IEF SSP 5111 3
  • 29-KD MCP Activator Subunit 3
  • HEL-S-129m 3
  • REG-Alpha 4
  • REGalpha 3
  • PA28A 3
  • PA28a 4

External Ids for PSME1 Gene

Previous GeneCards Identifiers for PSME1 Gene

  • GC14P021977
  • GC14P018392
  • GC14P022595
  • GC14P023675
  • GC14P023661
  • GC14P024605
  • GC14P004720

Summaries for PSME1 Gene

Entrez Gene Summary for PSME1 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for PSME1 Gene

PSME1 (Proteasome Activator Subunit 1) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and RET signaling. Gene Ontology (GO) annotations related to this gene include endopeptidase activator activity. An important paralog of this gene is PSME2.

UniProtKB/Swiss-Prot for PSME1 Gene

  • Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.

Gene Wiki entry for PSME1 Gene

Additional gene information for PSME1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSME1 Gene

Genomics for PSME1 Gene

GeneHancer (GH) Regulatory Elements for PSME1 Gene

Promoters and enhancers for PSME1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J024135 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 650.7 +0.4 413 2.9 HDGF CLOCK FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF213 PSME1 EMC9 RNF31 KHNYN RNA5SP383 TINF2 TM9SF1 CIDEB TSSK4 LOC102724814
GH14J024113 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.9 -21.3 -21318 3.1 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 SP3 NRL DCAF11 RNF31 KHNYN RNA5SP383 IPO4 TM9SF1 TINF2 TSSK4 NFATC4
GH14J024108 Enhancer 1.2 Ensembl ENCODE 11.3 -27.3 -27300 1.5 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 EMC9 CPNE6 CARMIL3 FITM1 PSME1 IRF9 TSSK4 PSME2 RNF31 TM9SF1
GH14J024106 Enhancer 0.7 Ensembl 11.3 -29.9 -29857 0.2 ELF3 IRF2 ARID4B KAT7 ERF THRB RBPJ RAD21 RARA ZNF205 CPNE6 CARMIL3 FITM1 PSME1 IRF9 TSSK4 EMC9 PSME2 RNF31 TM9SF1
GH14J024240 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 2.9 +106.1 106082 3.8 PKNOX1 SMAD1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B TINF2 KHNYN RNA5SP383 LOC102724814 RNF31 TM9SF1 CIDEB TSSK4 THTPA TGM1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSME1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PSME1 gene promoter:
  • TBP
  • AML1a
  • SREBP-1a
  • SREBP-1b

Genomic Locations for PSME1 Gene

Genomic Locations for PSME1 Gene
2,810 bases
Plus strand
2,810 bases
Plus strand

Genomic View for PSME1 Gene

Genes around PSME1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSME1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSME1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSME1 Gene

Proteins for PSME1 Gene

  • Protein details for PSME1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Proteasome activator complex subunit 1
    Protein Accession:
    Secondary Accessions:
    • A6NJG9
    • H0YNE3
    • Q6IBM2
    • Q9UEF4

    Protein attributes for PSME1 Gene

    249 amino acids
    Molecular mass:
    28723 Da
    Quaternary structure:
    • Heterodimer of PSME1 and PSME2, which forms a hexameric ring. PSME1 can form homoheptamers.

    Three dimensional structures from OCA and Proteopedia for PSME1 Gene

    Alternative splice isoforms for PSME1 Gene


neXtProt entry for PSME1 Gene

Post-translational modifications for PSME1 Gene

  • Ubiquitination at Lys245, posLast=176176, posLast=3535, posLast=2424, and Lys13
  • Modification sites at PhosphoSitePlus

Other Protein References for PSME1 Gene

No data available for DME Specific Peptides for PSME1 Gene

Domains & Families for PSME1 Gene

Gene Families for PSME1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PA28 family.
  • Belongs to the PA28 family.
genes like me logo Genes that share domains with PSME1: view

Function for PSME1 Gene

Molecular function for PSME1 Gene

UniProtKB/Swiss-Prot Function:
Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.
UniProtKB/Swiss-Prot Induction:
By IFNG/IFN-gamma.
GENATLAS Biochemistry:
multicatalytic proteinase complex (prosome,macropain,20S),proteasome activator PA28 alpha, homologous to Ki antigen,stimulated by interferon gamma

Gene Ontology (GO) - Molecular Function for PSME1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0061133 endopeptidase activator activity IBA --
genes like me logo Genes that share ontologies with PSME1: view
genes like me logo Genes that share phenotypes with PSME1: view

Animal Models for PSME1 Gene

MGI Knock Outs for PSME1:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PSME1 Gene

Localization for PSME1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSME1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for PSME1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex TAS 8811196
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm TAS 16130169
GO:0005829 cytosol TAS --
GO:0008537 proteasome activator complex IEA --
genes like me logo Genes that share ontologies with PSME1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for PSME1 Gene

Pathways & Interactions for PSME1 Gene

SuperPathways for PSME1 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
2 RET signaling
3 HIV Life Cycle
4 Class I MHC mediated antigen processing and presentation
5 Antigen processing-Cross presentation
genes like me logo Genes that share pathways with PSME1: view

Gene Ontology (GO) - Biological Process for PSME1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006521 regulation of cellular amino acid metabolic process TAS --
genes like me logo Genes that share ontologies with PSME1: view

No data available for SIGNOR curated interactions for PSME1 Gene

Drugs & Compounds for PSME1 Gene

(3) Drugs for PSME1 Gene - From: DrugBank and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Target 202
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 826
carfilzomib Approved, Investigational Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
genes like me logo Genes that share compounds with PSME1: view

Transcripts for PSME1 Gene

mRNA/cDNA for PSME1 Gene

Unigene Clusters for PSME1 Gene

Proteasome (prosome, macropain) activator subunit 1 (PA28 alpha):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSME1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11

Relevant External Links for PSME1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PSME1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSME1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PSME1 Gene

This gene is overexpressed in Whole Blood (x5.4).

Protein differential expression in normal tissues from HIPED for PSME1 Gene

This gene is overexpressed in Spleen (6.6) and Tlymphocyte (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSME1 Gene

Protein tissue co-expression partners for PSME1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PSME1 Gene:


SOURCE GeneReport for Unigene cluster for PSME1 Gene:


Evidence on tissue expression from TISSUES for PSME1 Gene

  • Blood(4.7)
  • Lung(4.7)
  • Liver(4.6)
  • Spleen(4.6)
  • Muscle(4.4)
  • Skin(4.4)
  • Nervous system(3.7)
  • Kidney(2.8)
  • Lymph node(2.6)
  • Intestine(2.4)
  • Bone marrow(2.3)
  • Pancreas(2.2)
  • Stomach(2.2)
  • Heart(2.1)
  • Adrenal gland(2)
  • Gall bladder(2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with PSME1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSME1 Gene

Orthologs for PSME1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PSME1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PSME1 34 33
  • 99.87 (n)
(Canis familiaris)
Mammalia PSME1 34 33
  • 94.24 (n)
(Bos Taurus)
Mammalia PSME1 34 33
  • 94.24 (n)
(Mus musculus)
Mammalia Psme1 16 34 33
  • 89.96 (n)
(Rattus norvegicus)
Mammalia Psme1 33
  • 89.83 (n)
(Monodelphis domestica)
Mammalia PSME1 34
  • 74 (a)
(Anolis carolinensis)
Reptilia PSME1 34
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia psme1 33
  • 62.43 (n)
Str.6276 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.24011 33
(Danio rerio)
Actinopterygii psme1 34 33 33
  • 61.92 (n)
fruit fly
(Drosophila melanogaster)
Insecta REG 34
  • 32 (a)
(Caenorhabditis elegans)
Secernentea Y66D12A.9 34
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 32 (a)
-- 34
  • 31 (a)
-- 34
  • 30 (a)
Species where no ortholog for PSME1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSME1 Gene

Gene Tree for PSME1 (if available)
Gene Tree for PSME1 (if available)
Evolutionary constrained regions (ECRs) for PSME1: view image

Paralogs for PSME1 Gene

Paralogs for PSME1 Gene

(2) SIMAP similar genes for PSME1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PSME1: view

Variants for PSME1 Gene

Sequence variations from dbSNP and Humsavar for PSME1 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1001130970 -- 24,134,259(+) T/A upstream_transcript_variant
rs1001520840 -- 24,136,145(+) CCCTCCCC/CCCTCCCCTCCCC upstream_transcript_variant
rs1001890608 -- 24,134,267(+) A/T upstream_transcript_variant
rs1002144510 -- 24,139,041(+) A/G downstream_transcript_variant
rs1003582189 -- 24,135,089(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PSME1 Gene

Variant ID Type Subtype PubMed ID
nsv564057 CNV loss 21841781

Variation tolerance for PSME1 Gene

Residual Variation Intolerance Score: 48.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.66; 14.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PSME1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSME1 Gene

Disorders for PSME1 Gene

Additional Disease Information for PSME1

No disorders were found for PSME1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSME1 Gene

Publications for PSME1 Gene

  1. Interferon-gamma up-regulates a unique set of proteins in human keratinocytes. Molecular cloning and expression of the cDNA encoding the RGD-sequence-containing protein IGUP I-5111. (PMID: 8269930) Honoré B … Celis JE (European journal of biochemistry 1993) 2 3 4 22 58
  2. The proteasome 11S regulator subunit REG alpha (PA28 alpha) is a heptamer. (PMID: 9385652) Johnston SC … Hill CP (Protein science : a publication of the Protein Society 1997) 3 4 22 58
  3. Structure of the proteasome activator REGalpha (PA28alpha). (PMID: 9403698) Knowlton JR … Hill CP (Nature 1997) 3 4 22 58
  4. Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X … Huang L (Biochemistry 2007) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for PSME1 Gene