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The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2012]
PSMD9 (Proteasome 26S Subunit, Non-ATPase 9) is a Protein Coding gene. Diseases associated with PSMD9 include Carpal Tunnel Syndrome and Generalized Anxiety Disorder. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Antigen processing-Cross presentation. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and bHLH transcription factor binding. An important paralog of this gene is ENSG00000256950.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003713 | transcription coactivator activity | ISS | 10567574 |
GO:0005515 | protein binding | IPI | 16189514 |
GO:0043425 | bHLH transcription factor binding | ISS | 10567574 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA,ISS | 10567574 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005829 | cytosol | TAS | -- |
GO:0005838 | proteasome regulatory particle | NAS | 9653651 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Regulation of activated PAK-2p34 by proteasome mediated degradation |
.93
.93
|
.80
.79
.78
.69
.47
|
2 | RET signaling |
.92
|
.92
|
3 | HIV Life Cycle |
.65
|
.45
|
4 | Parkinson disease | ||
5 | Class I MHC mediated antigen processing and presentation |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000165 | MAPK cascade | TAS | -- |
GO:0000209 | protein polyubiquitination | TAS | -- |
GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
GO:0006511 | ubiquitin-dependent protein catabolic process | NAS | 9653651 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||
SP4: | - | - | - | - | - | ||||||||||||||||||||||
SP5: | - | - |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PSMD9 30 |
|
||
-- 31 |
|
OneToMany | |||
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
PSMD9 30 |
|
||||
Cow (Bos Taurus) |
Mammalia | PSMD9 30 31 |
|
OneToMany | |
Mouse (Mus musculus) |
Mammalia | Psmd9 30 17 31 |
|
OneToMany | |
Rat (Rattus norvegicus) |
Mammalia | Psmd9 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | PSMD9 30 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | psmd9 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | psmd9 30 31 |
|
OneToMany | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG9588 30 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | psmd-9 31 |
|
OneToMany | |
C44B7.1 32 |
|
|
|||
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ADL013C 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | NAS2 30 31 33 |
|
OneToMany | |
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0D14135g 30 |
|
||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT5G57950 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os09g0420600 30 |
|
||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU11053 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC2H10.02c 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2661361 | CNV | deletion | 23128226 |
esv3581938 | CNV | gain | 25503493 |
esv3630961 | CNV | loss | 21293372 |
nsv474446 | CNV | novel sequence insertion | 20440878 |
Disorder | Aliases | PubMed IDs |
---|---|---|
carpal tunnel syndrome |
|
|
generalized anxiety disorder |
|
|
progressive myoclonus epilepsy 10 |
|
|
maturity-onset diabetes of the young, type 3 |
|
|
high-grade astrocytoma |
|
|