PSMD9 Gene (Protein Coding)

Proteasome 26S Subunit, Non-ATPase 9

GC12P122847
GIFtS:
43
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 n... See more...

Aliases for PSMD9 Gene

Aliases for PSMD9 Gene

  • Proteasome 26S Subunit, Non-ATPase 9 2 3 5
  • Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 9 2 3
  • 26S Proteasome Non-ATPase Regulatory Subunit 9 3 4
  • 26S Proteasome Regulatory Subunit P27 3 4
  • Rpn4 2 3
  • P27 2 3
  • Proteasome 26S Non-ATPase Regulatory Subunit 9 3
  • Homolog Of Rat Bridge 1 3
  • PSMD9 5

External Ids for PSMD9 Gene

Previous GeneCards Identifiers for PSMD9 Gene

  • GC12P120852
  • GC12M121795
  • GC12P122095
  • GC12P120724
  • GC12P120789
  • GC12P122326
  • GC12P119337
  • GC12P121950
  • GC12P121957
  • GC12P122344
  • GC12P122425
  • GC12P122450
  • GC12P122644
  • GC12P121963
  • GC12P121970
  • GC12P121975
  • GC12P122008
  • GC12P122060
  • GC12P122111
  • GC12P122186
  • GC12P122266

Summaries for PSMD9 Gene

Entrez Gene Summary for PSMD9 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for PSMD9 Gene

PSMD9 (Proteasome 26S Subunit, Non-ATPase 9) is a Protein Coding gene. Diseases associated with PSMD9 include Carpal Tunnel Syndrome and Generalized Anxiety Disorder. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Antigen processing-Cross presentation. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and bHLH transcription factor binding. An important paralog of this gene is ENSG00000256950.

UniProtKB/Swiss-Prot Summary for PSMD9 Gene

  • Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process.

Gene Wiki entry for PSMD9 Gene

Additional gene information for PSMD9 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSMD9 Gene

Genomics for PSMD9 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for PSMD9 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH12J121887 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 616.2 +0.6 569 3 ARHGAP35 SP1 HNRNPL CREB1 GATAD2A CTCF ATF7 TEAD4 PRDM10 ZNF629 PSMD9 ENSG00000256950 ENSG00000287493 HPD RF02000-003 RSRC2 KNTC1 ZCCHC8 CFAP251 LINC01089
GH12J121892 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 600.4 +5.1 5050 4.4 CTCF TFE3 IKZF1 JUND FOXA1 MTA2 PHF21A PKNOX1 NR2C1 HDAC1 PSMD9 CFAP251 ENSG00000256950 ENSG00000283389 RF02000-003
GH12J121915 Promoter/Enhancer 0.8 EPDnew ENCODE 600.3 +27.3 27323 0.9 ZIC2 CEBPB FEZF1 GLIS1 piR-53685 PSMD9 CFAP251 RNU7-170P RF00066-054 ENSG00000256950
GH12J121886 Enhancer 0.2 Ensembl 600.7 -1.8 -1831 0.2 ENSG00000256950 ENSG00000287493 HPD PSMD9 CFAP251 ENSG00000278084 SETD1B
GH12J121783 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 23.4 -92.7 -92740 24.5 ARHGAP35 CEBPG SP1 HNRNPL CREB1 GATAD2A CTCF ATF7 TEAD4 PRDM10 ENSG00000272849 LINC01089 SETD1B RHOF lnc-SETD1B-3 RSRC2 ZCCHC8 ANAPC5 PSMD9 HPD
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSMD9 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PSMD9

Top Transcription factor binding sites by QIAGEN in the PSMD9 gene promoter:
  • AML1a
  • GR
  • GR-alpha
  • GR-beta
  • HTF
  • N-Myc
  • PPAR-gamma1
  • PPAR-gamma2
  • XBP-1

Genomic Locations for PSMD9 Gene

Genomic Locations for PSMD9 Gene
chr12:121,888,732-121,918,297
(GRCh38/hg38)
Size:
29,566 bases
Orientation:
Plus strand
chr12:122,326,637-122,356,203
(GRCh37/hg19)
Size:
29,567 bases
Orientation:
Plus strand

Genomic View for PSMD9 Gene

Genes around PSMD9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMD9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMD9 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PSMD9 Gene

Proteins for PSMD9 Gene

Products:

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  • Protein details for PSMD9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00233-PSMD9_HUMAN
    Recommended name:
    26S proteasome non-ATPase regulatory subunit 9
    Protein Accession:
    O00233
    Secondary Accessions:
    • B2RD35
    • G3V1Q6
    • Q9BQ42

    Protein attributes for PSMD9 Gene

    Size:
    223 amino acids
    Molecular mass:
    24682 Da
    Quaternary structure:
    • Interacts with PSMC3. Part of a transient complex (modulator) containing PSMD9, PSMC6 and PSMC3 formed during the assembly of the 26S proteasome.

    Alternative splice isoforms for PSMD9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMD9 Gene

Protein Expression for PSMD9 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for PSMD9 Gene

  • Ubiquitination at Lys211, Lys117, and Lys123
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMD9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PSMD9 Gene

Domains & Families for PSMD9 Gene

Gene Families for PSMD9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PSMD9 Gene

InterPro:
Blocks:
  • PDZ/DHR/GLGF domain
ProtoNet:

Suggested Antigen Peptide Sequences for PSMD9 Gene

GenScript: Design optimal peptide antigens:
  • 26S proteasome regulatory subunit p27 (PSMD9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O00233

UniProtKB/Swiss-Prot:

PSMD9_HUMAN :
  • Belongs to the proteasome subunit p27 family.
Family:
  • Belongs to the proteasome subunit p27 family.
genes like me logo Genes that share domains with PSMD9: view

Function for PSMD9 Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for PSMD9 Gene

UniProtKB/Swiss-Prot Function:
Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process.
GENATLAS Biochemistry:
multicatalytic proteinase proteasome (prosome,macropain,26S) component,19/22S regulator of proteasome,non ATPase subunit p27 (23-25kDa),with two alternatively spliced isogforms,ubiquitously expressed with highly expresseion in liver and kidney,homolog to S cerevisiae NAS2 gene

Phenotypes From GWAS Catalog for PSMD9 Gene

Gene Ontology (GO) - Molecular Function for PSMD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity ISS 10567574
GO:0005515 protein binding IPI 16189514
GO:0043425 bHLH transcription factor binding ISS 10567574
genes like me logo Genes that share ontologies with PSMD9: view
genes like me logo Genes that share phenotypes with PSMD9: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMD9

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMD9 Gene

Localization for PSMD9 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMD9 gene
Compartment Confidence
cytosol 5
cytoskeleton 4
nucleus 4
plasma membrane 2
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PSMD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,ISS 10567574
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
GO:0005838 proteasome regulatory particle NAS 9653651
genes like me logo Genes that share ontologies with PSMD9: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PSMD9 Gene

Pathways & Interactions for PSMD9 Gene

PathCards logo

SuperPathways for PSMD9 Gene

SuperPathway Contained pathways
1 Regulation of activated PAK-2p34 by proteasome mediated degradation
Activation of APC/C and APC/C-Cdc20 mediated degradation of mitotic proteins
.95
Cdc20-Phospho-APC/C mediated degradation of Cyclin A
.95
Autodegradation of the E3 ubiquitin ligase COP1
.95
Stabilization of p53
.95
Regulation of activated PAK-2p34 by proteasome mediated degradation
.94
Regulation of Apoptosis
.94
CDK-mediated phosphorylation and removal of Cdc6
.94
Ubiquitin-dependent degradation of Cyclin D
.94
Ubiquitin-dependent degradation of Cyclin D1
.94
Orc1 removal from chromatin
.93
Regulation of DNA replication
.93
Switching of origins to a post-replicative state
.93
Cyclin A-Cdk2-associated events at S phase entry
.93
Cyclin E associated events during G1/S transition
.93
APC/C-Cdc20 mediated degradation of Securin
.93
APC/C-Cdh1 mediated degradation of Cdc20 and other APC/C-Cdh1 targeted proteins in late mitosis/early G1
.93
APC/C-mediated degradation of cell cycle proteins
.93
Regulation of APC/C activators between G1/S and early anaphase
.93
Regulation of mitotic cell cycle
.93
DNA Replication
.93
Synthesis of DNA
.93
Vpu mediated degradation of CD4
.92
Autodegradation of Cdh1 by Cdh1-APC/C
.91
SCF-beta-TrCP mediated degradation of Emi1
.91
p53-Independent DNA Damage Response
.91
p53-Independent G1/S DNA damage checkpoint
.91
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
.91
ABC transporter disorders
.91
Disorders of transmembrane transporters
.91
Defective CFTR causes cystic fibrosis
.90
Assembly of the pre-replicative complex
.89
Hedgehog ligand biogenesis
.89
Hh mutants abrogate ligand secretion
.89
APC/C-Cdc20 mediated degradation of mitotic proteins
.89
APC-Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
.89
Vif-mediated degradation of APOBEC3G
.89
Degradation of GLI1 by the proteasome
.89
Degradation of GLI2 by the proteasome
.89
GLI3 is processed to GLI3R by the proteasome
.89
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
.88
Degradation of AXIN
.88
Cellular response to hypoxia
.87
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
.87
Regulation of Hypoxia-inducible Factor (HIF) by oxygen
.87
CDT1 association with the CDC6-ORC-origin complex
.87
Hh mutants that dont undergo autocatalytic processing are degraded by ERAD
.86
AUF1 (hnRNP D0) binds and destabilizes mRNA
.86
p53-Dependent G1 DNA Damage Response
.86
p53-Dependent G1/S DNA damage checkpoint
.86
SCF(Skp2)-mediated degradation of p27/p21
.86
Removal of licensing factors from origins
.86
NIK-->noncanonical NF-kB signaling
.85
Dectin-1 mediated noncanonical NF-kB signaling
.84
G1/S DNA Damage Checkpoints
.83
Degradation of DVL
.83
Cross-presentation of soluble exogenous antigens (endosomes)
.82
The role of GTSE1 in G2/M progression after G2 checkpoint
.81
Regulation of ornithine decarboxylase (ODC)
.80
DNA Replication Pre-Initiation
.80
M/G1 Transition
.80
Proteasome
.79
S Phase
.78
Activation of NF-kappaB in B cells
.76
Asymmetric localization of PCP proteins
.73
FCERI mediated NF-kB activation
.72
Regulation of RAS by GAPs
.70
PCP/CE pathway
.69
Beta-catenin independent WNT signaling
.64
Degradation of beta-catenin by the destruction complex
.63
Regulation of mRNA stability by proteins that bind AU-rich elements
.62
Metabolism of polyamines
.59
ABC-family proteins mediated transport
.58
TNFR2 non-canonical NF-kB pathway
.57
MAPK6/MAPK4 signaling
.56
Proteasome Degradation
.55
UCH proteinases
.47
2 RET signaling
Frs2-mediated activation
.95
GRB2 events in EGFR signaling
.95
MAPK1/MAPK3 signaling
.95
Prolonged ERK activation events
.95
RAF/MAP kinase cascade
.95
SHC1 events in EGFR signaling
.95
Signaling by Leptin
.95
SOS-mediated signalling
.95
VEGFR2 mediated cell proliferation
.95
ARMS-mediated activation
.95
Signalling to ERKs
.95
Signalling to p38 via RIT and RIN
.95
Signalling to RAS
.95
Interleukin receptor SHC signaling
.95
Interleukin-3, 5 and GM-CSF signaling
.94
Interleukin-2 signaling
.94
Downstream signal transduction
.94
Signaling by PDGF
.94
DAP12 signaling
.92
RET signaling
.92
Insulin receptor signalling cascade
.92
Signaling by Insulin receptor
.92
IRS-mediated signalling
.91
Signaling by EGFR
.90
FCERI mediated MAPK activation
.90
IGF1R signaling cascade
.90
IRS-related events triggered by IGF1R
.90
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
.90
DAP12 interactions
.89
NCAM signaling for neurite out-growth
.89
NGF signalling via TRKA from the plasma membrane
.87
MAPK family signaling cascades
.87
Signaling by SCF-KIT
.85
Signalling by NGF
.81
Fc epsilon receptor (FCERI) signaling
.79
VEGFA-VEGFR2 Pathway
.78
Signaling by VEGF
.76
Gastrin-CREB signalling pathway via PKC and MAPK
.55
3 HIV Life Cycle
HIV Infection
.65
Infectious disease
.61
Host Interactions of HIV factors
.57
Disease
.45
Diseases of signal transduction
.43
4 Parkinson disease
Huntington disease
.46
Parkinson disease
.46
Alzheimer disease
.45
5 Class I MHC mediated antigen processing and presentation
Antigen processing- Ubiquitination and Proteasome degradation
.83
Class I MHC mediated antigen processing and presentation
.83
Adaptive Immune System
.45
genes like me logo Genes that share pathways with PSMD9: view

Pathways by source for PSMD9 Gene

3 GeneGo (Thomson Reuters) pathways for PSMD9 Gene
  • Immune response Antigen presentation by MHC class I
  • Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
  • Transcription Ligand-Dependent Transcription of Retinoid-Target genes
2 Qiagen pathways for PSMD9 Gene
  • RAR-Gamma-RXR-Alpha Degradation
  • Remodeling of Adherens Junctions

Gene Ontology (GO) - Biological Process for PSMD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006511 ubiquitin-dependent protein catabolic process NAS 9653651
genes like me logo Genes that share ontologies with PSMD9: view

No data available for SIGNOR curated interactions for PSMD9 Gene

Drugs & Compounds for PSMD9 Gene

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(2) Drugs for PSMD9 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 910
carfilzomib Approved, Investigational Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0

(1) Additional Compounds for PSMD9 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PSMD9: view

Transcripts for PSMD9 Gene

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  1. CRISPR
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mRNA/cDNA for PSMD9 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMD9

Alternative Splicing Database (ASD) splice patterns (SP) for PSMD9 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: -
SP2: -
SP3:
SP4: - - - - -
SP5: - -

Relevant External Links for PSMD9 Gene

GeneLoc Exon Structure for
PSMD9

Expression for PSMD9 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PSMD9 Gene

mRNA expression in normal human tissues for PSMD9 Gene
mRNA expression by BioGPS for PSMD9 GenemRNA expression by GTEx for PSMD9 Gene

Protein differential expression in normal tissues from HIPED for PSMD9 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMD9 Gene



Protein tissue co-expression partners for PSMD9 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PSMD9

SOURCE GeneReport for Unigene cluster for PSMD9 Gene:

Hs.131151

mRNA Expression by UniProt/SwissProt for PSMD9 Gene:

O00233-PSMD9_HUMAN
Tissue specificity: Expressed in all tissues tested, highly expressed in liver and kidney.

Evidence on tissue expression from TISSUES for PSMD9 Gene

  • Nervous system(4.7)
  • Muscle(4.4)
  • Liver(4.4)
  • Skin(2.3)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with PSMD9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMD9 Gene

Orthologs for PSMD9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMD9 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia PSMD9 30
  • 99.55 (n)
-- 31
  • 98 (a)
 OneToMany
Dog
(Canis familiaris)
 Mammalia -- 31
  • 92 (a)
 OneToMany
PSMD9 30
  • 88.94 (n)
Cow
(Bos Taurus)
 Mammalia PSMD9 30 31
  • 88.39 (n)
 OneToMany
Mouse
(Mus musculus)
 Mammalia Psmd9 30 17 31
  • 84.08 (n)
 OneToMany
Rat
(Rattus norvegicus)
 Mammalia Psmd9 30
  • 83.03 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 31
  • 78 (a)
 OneToMany
Oppossum
(Monodelphis domestica)
 Mammalia -- 31
  • 75 (a)
 OneToMany
Chicken
(Gallus gallus)
 Aves PSMD9 30 31
  • 74.06 (n)
 OneToMany
Lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 72 (a)
 OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia psmd9 30
  • 64.5 (n)
Zebrafish
(Danio rerio)
 Actinopterygii psmd9 30 31
  • 62.12 (n)
 OneToMany
Fruit Fly
(Drosophila melanogaster)
 Insecta CG9588 30 31 32
  • 53.33 (n)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea psmd-9 31
  • 34 (a)
 OneToMany
C44B7.1 32
  • 34 (a)
A. gosspyii yeast
(Eremothecium gossypii)
 Saccharomycetes AGOS_ADL013C 30
  • 46.46 (n)
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes NAS2 30 31 33
  • 46.06 (n)
 OneToMany
K. Lactis Yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0D14135g 30
  • 45.97 (n)
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons AT5G57950 30
  • 42.81 (n)
Rice
(Oryza sativa)
 Liliopsida Os09g0420600 30
  • 44.62 (n)
Bread mold
(Neurospora crassa)
 Ascomycetes NCU11053 30
  • 49 (n)
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 44 (a)
 OneToMany
Fission Yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes SPAC2H10.02c 30
  • 42.31 (n)
Species where no ortholog for PSMD9 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PSMD9 Gene

ENSEMBL:
Gene Tree for PSMD9 (if available)
TreeFam:
Gene Tree for PSMD9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PSMD9: view image

Paralogs for PSMD9 Gene

Paralogs for PSMD9 Gene

genes like me logo Genes that share paralogs with PSMD9: view

Variants for PSMD9 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PSMD9 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs1177573 - p.Arg134Trp
rs14259 - p.Glu197Gly
rs2230681 - p.Val17Ala
rs2291116 - p.Thr74Ile

Additional dbSNP identifiers (rs#s) for PSMD9 Gene

Structural Variations from Database of Genomic Variants (DGV) for PSMD9 Gene

Variant ID Type Subtype PubMed ID
esv2661361 CNV deletion 23128226
esv3581938 CNV gain 25503493
esv3630961 CNV loss 21293372
nsv474446 CNV novel sequence insertion 20440878

Variation tolerance for PSMD9 Gene

Residual Variation Intolerance Score: 90.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.05; 87.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PSMD9 Gene

Human Gene Mutation Database (HGMD)
PSMD9
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMD9

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMD9 Gene

Disorders for PSMD9 Gene

MalaCards: The human disease database

(7) MalaCards diseases for PSMD9 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search PSMD9 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PSMD9

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with PSMD9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSMD9 Gene

Publications for PSMD9 Gene

  1. cDNA cloning and characterization of a human proteasomal modulator subunit, p27 (PSMD9). (PMID: 9653651) Watanabe TK … Tanaka K (Genomics 1998) 2 3 4 23
  2. Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones. (PMID: 19490896) Kaneko T … Murata S (Cell 2009) 3 4
  3. Polymorphisms in inflammation-related genes are associated with susceptibility to major depression and antidepressant response. (PMID: 18504423) Wong ML … Licinio J (Molecular psychiatry 2008) 3 41
  4. PSMD9 gene variants within NIDDM2 may rarely contribute to type 2 diabetes. (PMID: 17516568) Gragnoli C … Cronsell J (Journal of cellular physiology 2007) 3 41
  5. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PMID: 16712791) Wang AG … Kim NS (Biochemical and biophysical research communications 2006) 3 4

ExternalLinks

View latest publications for PSMD9 gene in Mastermind

Products for PSMD9 Gene