The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 n... See more...

Aliases for PSMD9 Gene

Aliases for PSMD9 Gene

  • Proteasome 26S Subunit, Non-ATPase 9 2 3 5
  • Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 9 2 3
  • 26S Proteasome Non-ATPase Regulatory Subunit 9 3 4
  • 26S Proteasome Regulatory Subunit P27 3 4
  • Proteasome 26S Non-ATPase Regulatory Subunit 9 3
  • Homolog Of Rat Bridge 1 3
  • Rpn4 3
  • P27 3

External Ids for PSMD9 Gene

Previous GeneCards Identifiers for PSMD9 Gene

  • GC12P120852
  • GC12M121795
  • GC12P122095
  • GC12P120724
  • GC12P120789
  • GC12P122326
  • GC12P119337
  • GC12P121950
  • GC12P121957
  • GC12P122344
  • GC12P122425
  • GC12P121963
  • GC12P121970
  • GC12P121975
  • GC12P122008
  • GC12P122060
  • GC12P122111
  • GC12P122186
  • GC12P122266

Summaries for PSMD9 Gene

Entrez Gene Summary for PSMD9 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for PSMD9 Gene

PSMD9 (Proteasome 26S Subunit, Non-ATPase 9) is a Protein Coding gene. Diseases associated with PSMD9 include Carpal Tunnel Syndrome and Nerve Compression Syndrome. Among its related pathways are Cellular Senescence (REACTOME) and TCR signaling (REACTOME). Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and bHLH transcription factor binding. An important paralog of this gene is ENSG00000256950.

UniProtKB/Swiss-Prot Summary for PSMD9 Gene

  • Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process.

Gene Wiki entry for PSMD9 Gene

Additional gene information for PSMD9 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSMD9 Gene

Genomics for PSMD9 Gene

GeneHancer (GH) Regulatory Elements for PSMD9 Gene

Promoters and enhancers for PSMD9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J121887 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 794.1 +0.6 570 3 GTF3C2 ZNF785 SIN3A ZNF24 SP1 ZBTB40 CTCF SIX5 ZBTB6 MLX PSMD9 ENSG00000256950 HPD ENSG00000287493 RF02000-003 lnc-HPD-3 KNTC1 ZCCHC8 RSRC2 SETD1B
GH12J121892 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 750.4 +5.1 5051 4.4 CTCF SMARCE1 USF2 RAD21 SP1 MLLT1 TFE3 BACH1 SMARCA4 ZNF384 PSMD9 WDR66 ENSG00000256950 ENSG00000283389 RF02000-003
GH12J121915 Promoter/Enhancer 0.7 EPDnew ENCODE 750.3 +27.3 27324 0.9 ZIC2 FEZF1 GLIS1 piR-53685 PSMD9 WDR66 RNU7-170P RF00066-054 ENSG00000256950
GH12J121783 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 76.7 -92.7 -92739 24.5 GTF3C2 SIN3A ZNF24 SP1 ZBTB40 CTCF SREBF1 ZBTB6 LCORL MLX SETD1B ENSG00000272849 RHOF lnc-SETD1B-3 ZCCHC8 RSRC2 PSMD9 ANAPC5 KNTC1 LINC01089
GH12J121886 Enhancer 0.2 Ensembl 750.6 -1.8 -1830 0.2 ENSG00000256950 HPD ENSG00000287493 PSMD9 lnc-HPD-3 WDR66 ENSG00000278084
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSMD9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PSMD9 gene promoter:
  • AML1a
  • GR
  • GR-alpha
  • GR-beta
  • HTF
  • N-Myc
  • PPAR-gamma1
  • PPAR-gamma2
  • XBP-1

Genomic Locations for PSMD9 Gene

Genomic Locations for PSMD9 Gene
chr12:121,888,731-121,918,297
(GRCh38/hg38)
Size:
29,567 bases
Orientation:
Plus strand
chr12:122,326,637-122,356,203
(GRCh37/hg19)
Size:
29,567 bases
Orientation:
Plus strand

Genomic View for PSMD9 Gene

Genes around PSMD9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMD9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMD9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMD9 Gene

Proteins for PSMD9 Gene

  • Protein details for PSMD9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00233-PSMD9_HUMAN
    Recommended name:
    26S proteasome non-ATPase regulatory subunit 9
    Protein Accession:
    O00233
    Secondary Accessions:
    • B2RD35
    • G3V1Q6
    • Q9BQ42

    Protein attributes for PSMD9 Gene

    Size:
    223 amino acids
    Molecular mass:
    24682 Da
    Quaternary structure:
    • Interacts with PSMC3. Part of a transient complex (modulator) containing PSMD9, PSMC6 and PSMC3 formed during the assembly of the 26S proteasome.

    Alternative splice isoforms for PSMD9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMD9 Gene

Post-translational modifications for PSMD9 Gene

  • Ubiquitination at Lys211, Lys117, and Lys123
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for PSMD9

No data available for DME Specific Peptides for PSMD9 Gene

Domains & Families for PSMD9 Gene

Gene Families for PSMD9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PSMD9 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PSMD9 Gene

GenScript: Design optimal peptide antigens:
  • 26S proteasome regulatory subunit p27 (PSMD9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O00233

UniProtKB/Swiss-Prot:

PSMD9_HUMAN :
  • Belongs to the proteasome subunit p27 family.
Family:
  • Belongs to the proteasome subunit p27 family.
genes like me logo Genes that share domains with PSMD9: view

Function for PSMD9 Gene

Molecular function for PSMD9 Gene

UniProtKB/Swiss-Prot Function:
Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process.
GENATLAS Biochemistry:
multicatalytic proteinase proteasome (prosome,macropain,26S) component,19/22S regulator of proteasome,non ATPase subunit p27 (23-25kDa),with two alternatively spliced isogforms,ubiquitously expressed with highly expresseion in liver and kidney,homolog to S cerevisiae NAS2 gene

Phenotypes From GWAS Catalog for PSMD9 Gene

Gene Ontology (GO) - Molecular Function for PSMD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity ISS 10567574
GO:0005515 protein binding IPI 16189514
GO:0043425 bHLH transcription factor binding ISS 10567574
genes like me logo Genes that share ontologies with PSMD9: view
genes like me logo Genes that share phenotypes with PSMD9: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMD9

Clone Products

  • Addgene plasmids for PSMD9

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMD9 Gene

Localization for PSMD9 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMD9 gene
Compartment Confidence
nucleus 4
cytosol 4
cytoskeleton 3
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PSMD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,ISS 10567574
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
GO:0005838 proteasome regulatory particle NAS 9653651
genes like me logo Genes that share ontologies with PSMD9: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PSMD9 Gene

Pathways & Interactions for PSMD9 Gene

PathCards logo

SuperPathways for PSMD9 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 HIV Life Cycle
.45
4 Class I MHC mediated antigen processing and presentation
5 Antigen processing-Cross presentation
genes like me logo Genes that share pathways with PSMD9: view

Gene Ontology (GO) - Biological Process for PSMD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006511 ubiquitin-dependent protein catabolic process NAS 9653651
genes like me logo Genes that share ontologies with PSMD9: view

No data available for SIGNOR curated interactions for PSMD9 Gene

Drugs & Compounds for PSMD9 Gene

(2) Drugs for PSMD9 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 878
carfilzomib Approved, Investigational Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0

(1) Additional Compounds for PSMD9 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PSMD9: view

Transcripts for PSMD9 Gene

mRNA/cDNA for PSMD9 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMD9

Clone Products

  • Addgene plasmids for PSMD9

Alternative Splicing Database (ASD) splice patterns (SP) for PSMD9 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: -
SP2: -
SP3:
SP4: - - - - -
SP5: - -

Relevant External Links for PSMD9 Gene

GeneLoc Exon Structure for
PSMD9
ECgene alternative splicing isoforms for
PSMD9

Expression for PSMD9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSMD9 Gene

Protein differential expression in normal tissues from HIPED for PSMD9 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMD9 Gene



Protein tissue co-expression partners for PSMD9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PSMD9 Gene:

PSMD9

SOURCE GeneReport for Unigene cluster for PSMD9 Gene:

Hs.131151

mRNA Expression by UniProt/SwissProt for PSMD9 Gene:

O00233-PSMD9_HUMAN
Tissue specificity: Expressed in all tissues tested, highly expressed in liver and kidney.

Evidence on tissue expression from TISSUES for PSMD9 Gene

  • Nervous system(4.6)
  • Muscle(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with PSMD9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMD9 Gene

Orthologs for PSMD9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMD9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMD9 32
  • 99.55 (n)
-- 33
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 33
  • 92 (a)
OneToMany
PSMD9 32
  • 88.94 (n)
cow
(Bos Taurus)
Mammalia PSMD9 33 32
  • 88.39 (n)
OneToMany
mouse
(Mus musculus)
Mammalia Psmd9 17 33 32
  • 84.08 (n)
rat
(Rattus norvegicus)
Mammalia Psmd9 32
  • 83.03 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 78 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 75 (a)
OneToMany
chicken
(Gallus gallus)
Aves PSMD9 33 32
  • 74.06 (n)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 72 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia psmd9 32
  • 64.5 (n)
zebrafish
(Danio rerio)
Actinopterygii psmd9 33 32
  • 62.12 (n)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG9588 33 34 32
  • 53.33 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea psmd-9 33
  • 34 (a)
OneToMany
C44B7.1 34
  • 34 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL013C 32
  • 46.46 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAS2 35 33 32
  • 46.06 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D14135g 32
  • 45.97 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G57950 32
  • 42.81 (n)
rice
(Oryza sativa)
Liliopsida Os09g0420600 32
  • 44.62 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU11053 32
  • 49 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 44 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC2H10.02c 32
  • 42.31 (n)
Species where no ortholog for PSMD9 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSMD9 Gene

ENSEMBL:
Gene Tree for PSMD9 (if available)
TreeFam:
Gene Tree for PSMD9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PSMD9: view image

Paralogs for PSMD9 Gene

Paralogs for PSMD9 Gene

genes like me logo Genes that share paralogs with PSMD9: view

Variants for PSMD9 Gene

Sequence variations from dbSNP and Humsavar for PSMD9 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000063943 -- 121,908,639(+) AAA/AA intron_variant
rs1000076437 -- 121,913,789(+) G/A intron_variant
rs1000111435 -- 121,904,263(+) C/A/T intron_variant
rs1000123134 -- 121,901,368(+) A/C intron_variant
rs1000132199 -- 121,907,204(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PSMD9 Gene

Variant ID Type Subtype PubMed ID
esv2661361 CNV deletion 23128226
esv3581938 CNV gain 25503493
esv3630961 CNV loss 21293372
nsv474446 CNV novel sequence insertion 20440878

Variation tolerance for PSMD9 Gene

Residual Variation Intolerance Score: 90.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.05; 87.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PSMD9 Gene

Human Gene Mutation Database (HGMD)
PSMD9
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMD9

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMD9 Gene

Disorders for PSMD9 Gene

MalaCards: The human disease database

(4) MalaCards diseases for PSMD9 Gene - From: HGMD, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search PSMD9 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PSMD9

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PSMD9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSMD9 Gene

Publications for PSMD9 Gene

  1. cDNA cloning and characterization of a human proteasomal modulator subunit, p27 (PSMD9). (PMID: 9653651) Watanabe TK … Tanaka K (Genomics 1998) 2 3 4 23 56
  2. Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones. (PMID: 19490896) Kaneko T … Murata S (Cell 2009) 3 4 56
  3. Polymorphisms in inflammation-related genes are associated with susceptibility to major depression and antidepressant response. (PMID: 18504423) Wong ML … Licinio J (Molecular psychiatry 2008) 3 43 56
  4. PSMD9 gene variants within NIDDM2 may rarely contribute to type 2 diabetes. (PMID: 17516568) Gragnoli C … Cronsell J (Journal of cellular physiology 2007) 3 43 56
  5. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PMID: 16712791) Wang AG … Kim NS (Biochemical and biophysical research communications 2006) 3 4 56

Products for PSMD9 Gene