The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 n... See more...

Aliases for PSMD9 Gene

Aliases for PSMD9 Gene

  • Proteasome 26S Subunit, Non-ATPase 9 2 3 5
  • Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 9 2 3
  • 26S Proteasome Non-ATPase Regulatory Subunit 9 3 4
  • 26S Proteasome Regulatory Subunit P27 3 4
  • Rpn4 2 3
  • P27 2 3
  • Proteasome 26S Non-ATPase Regulatory Subunit 9 3
  • Homolog Of Rat Bridge 1 3
  • PSMD9 5

External Ids for PSMD9 Gene

Previous GeneCards Identifiers for PSMD9 Gene

  • GC12P120852
  • GC12M121795
  • GC12P122095
  • GC12P120724
  • GC12P120789
  • GC12P122326
  • GC12P119337
  • GC12P121950
  • GC12P121957
  • GC12P122344
  • GC12P122425
  • GC12P122450
  • GC12P122644
  • GC12P121963
  • GC12P121970
  • GC12P121975
  • GC12P122008
  • GC12P122060
  • GC12P122111
  • GC12P122186
  • GC12P122266
  • GC12P122847

Summaries for PSMD9 Gene

Entrez Gene Summary for PSMD9 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for PSMD9 Gene

PSMD9 (Proteasome 26S Subunit, Non-ATPase 9) is a Protein Coding gene. Diseases associated with PSMD9 include Carpal Tunnel Syndrome and Generalized Anxiety Disorder. Among its related pathways are Downstream signaling events of B Cell Receptor (BCR) and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and bHLH transcription factor binding. An important paralog of this gene is ENSG00000256950.

UniProtKB/Swiss-Prot Summary for PSMD9 Gene

  • Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process.

Gene Wiki entry for PSMD9 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSMD9 Gene

Genomics for PSMD9 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PSMD9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J121887 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 266.2 +0.6 569 3 CHD2 TBP SP1 ZBTB10 MXD4 FEZF1 CEBPA SIX5 NR2C1 MNT PSMD9 ENSG00000256950 ENSG00000287493 HPD RF02000-003 RSRC2 KNTC1 ZCCHC8 CFAP251 LINC01089
GH12J121892 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 250.4 +5.7 5677 3.1 TBP IKZF1 CTCF NFATC3 FOXA2 NBN SAP130 ZFP91 JUND ZNF316 PSMD9 CFAP251 ENSG00000283389 RF02000-003 ENSG00000256950
GH12J121915 Promoter/Enhancer 0.8 EPDnew ENCODE 250.3 +27.3 27323 0.9 FEZF1 ZIC2 GLIS1 CEBPB piR-53685 PSMD9 CFAP251 RF00066-054 RNU7-170P HSALNG0094614 ENSG00000256950
GH12J122265 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 33.1 +377.6 377592 2.6 ZSCAN16 CHD2 TBP ZBTB10 SP1 MXD4 FEZF1 NR2C1 DEK MNT ENSG00000256861 HSALNG0094642 VPS33A RSRC2 ZCCHC8 ENSG00000272849 MTRFR ANAPC5 KNTC1 OGFOD2
GH12J121783 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 23.4 -92.7 -92740 24.5 CHD2 TBP ZBTB10 SP1 MXD4 FEZF1 CEBPA NR2C1 MNT DEK ENSG00000272849 LINC01089 SETD1B RHOF HSALNG0094607 lnc-SETD1B-3 RSRC2 ZCCHC8 ANAPC5 PSMD9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSMD9 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PSMD9

Top Transcription factor binding sites by QIAGEN in the PSMD9 gene promoter:
  • AML1a
  • GR
  • GR-alpha
  • GR-beta
  • HTF
  • N-Myc
  • PPAR-gamma1
  • PPAR-gamma2
  • XBP-1

Genomic Locations for PSMD9 Gene

Latest Assembly
chr12:121,888,732-121,918,297
(GRCh38/hg38)
Size:
29,566 bases
Orientation:
Plus strand

Previous Assembly
chr12:122,326,696-122,356,203
(GRCh37/hg19 by Entrez Gene)
Size:
29,508 bases
Orientation:
Plus strand

chr12:122,326,637-122,356,203
(GRCh37/hg19 by Ensembl)
Size:
29,567 bases
Orientation:
Plus strand

Genomic View for PSMD9 Gene

Genes around PSMD9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMD9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMD9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMD9 Gene

Proteins for PSMD9 Gene

  • Protein details for PSMD9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00233-PSMD9_HUMAN
    Recommended name:
    26S proteasome non-ATPase regulatory subunit 9
    Protein Accession:
    O00233
    Secondary Accessions:
    • B2RD35
    • G3V1Q6
    • Q9BQ42

    Protein attributes for PSMD9 Gene

    Size:
    223 amino acids
    Molecular mass:
    24682 Da
    Quaternary structure:
    • Interacts with PSMC3. Part of a transient complex (modulator) containing PSMD9, PSMC6 and PSMC3 formed during the assembly of the 26S proteasome.

    Alternative splice isoforms for PSMD9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMD9 Gene

Post-translational modifications for PSMD9 Gene

  • Ubiquitination at Lys211, Lys117, and Lys123
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PSMD9 Gene

Domains & Families for PSMD9 Gene

Gene Families for PSMD9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PSMD9 Gene

InterPro:
Blocks:
  • PDZ/DHR/GLGF domain
ProtoNet:

Suggested Antigen Peptide Sequences for PSMD9 Gene

GenScript: Design optimal peptide antigens:
  • 26S proteasome regulatory subunit p27 (PSMD9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O00233

UniProtKB/Swiss-Prot:

PSMD9_HUMAN :
  • Belongs to the proteasome subunit p27 family.
Family:
  • Belongs to the proteasome subunit p27 family.
genes like me logo Genes that share domains with PSMD9: view

Function for PSMD9 Gene

Molecular function for PSMD9 Gene

UniProtKB/Swiss-Prot Function:
Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process.
GENATLAS Biochemistry:
multicatalytic proteinase proteasome (prosome,macropain,26S) component,19/22S regulator of proteasome,non ATPase subunit p27 (23-25kDa),with two alternatively spliced isogforms,ubiquitously expressed with highly expresseion in liver and kidney,homolog to S cerevisiae NAS2 gene

Phenotypes From GWAS Catalog for PSMD9 Gene

Gene Ontology (GO) - Molecular Function for PSMD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity ISS 10567574
GO:0005515 protein binding IPI 16189514
GO:0043425 bHLH transcription factor binding ISS 10567574
genes like me logo Genes that share ontologies with PSMD9: view
genes like me logo Genes that share phenotypes with PSMD9: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMD9

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMD9 Gene

Localization for PSMD9 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMD9 gene
Compartment Confidence
cytosol 5
cytoskeleton 4
nucleus 4
plasma membrane 2
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PSMD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,ISS 10567574
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
GO:0005838 proteasome regulatory particle NAS 9653651
genes like me logo Genes that share ontologies with PSMD9: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PSMD9 Gene

Pathways & Interactions for PSMD9 Gene

PathCards logo

SuperPathways for PSMD9 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 HIV Life Cycle
.45
4 Pathways of neurodegeneration - multiple diseases
5 Class I MHC mediated antigen processing and presentation
genes like me logo Genes that share pathways with PSMD9: view

Pathways by source for PSMD9 Gene

3 GeneGo (Thomson Reuters) pathways for PSMD9 Gene
  • Immune response Antigen presentation by MHC class I
  • Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
  • Transcription Ligand-Dependent Transcription of Retinoid-Target genes
2 Qiagen pathways for PSMD9 Gene
  • RAR-Gamma-RXR-Alpha Degradation
  • Remodeling of Adherens Junctions

Gene Ontology (GO) - Biological Process for PSMD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006511 ubiquitin-dependent protein catabolic process NAS 9653651
genes like me logo Genes that share ontologies with PSMD9: view

No data available for SIGNOR curated interactions for PSMD9 Gene

Drugs & Compounds for PSMD9 Gene

(2) Drugs for PSMD9 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 926
carfilzomib Approved, Investigational Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0

(1) Additional Compounds for PSMD9 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PSMD9: view

Transcripts for PSMD9 Gene

mRNA/cDNA for PSMD9 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMD9

Alternative Splicing Database (ASD) splice patterns (SP) for PSMD9 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: -
SP2: -
SP3:
SP4: - - - - -
SP5: - -

Relevant External Links for PSMD9 Gene

GeneLoc Exon Structure for
PSMD9

Expression for PSMD9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PSMD9 Gene

Protein differential expression in normal tissues from HIPED for PSMD9 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMD9 Gene



Protein tissue co-expression partners for PSMD9 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PSMD9

SOURCE GeneReport for Unigene cluster for PSMD9 Gene:

Hs.131151

mRNA Expression by UniProt/SwissProt for PSMD9 Gene:

O00233-PSMD9_HUMAN
Tissue specificity: Expressed in all tissues tested, highly expressed in liver and kidney.

Evidence on tissue expression from TISSUES for PSMD9 Gene

  • Nervous system(4.7)
  • Muscle(4.4)
  • Liver(4.4)
  • Skin(2.2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with PSMD9: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMD9 Gene

Orthologs for PSMD9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMD9 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PSMD9 30
  • 99.55 (n)
-- 31
  • 98 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 92 (a)
OneToMany
PSMD9 30
  • 88.94 (n)
Cow
(Bos Taurus)
Mammalia PSMD9 30 31
  • 88.39 (n)
OneToMany
Mouse
(Mus musculus)
Mammalia Psmd9 30 17 31
  • 84.08 (n)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Psmd9 30
  • 83.03 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 78 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 75 (a)
OneToMany
Chicken
(Gallus gallus)
Aves PSMD9 30 31
  • 74.06 (n)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 72 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia psmd9 30
  • 64.5 (n)
Zebrafish
(Danio rerio)
Actinopterygii psmd9 30 31
  • 62.12 (n)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG9588 30 31 32
  • 53.33 (n)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea psmd-9 31
  • 34 (a)
OneToMany
C44B7.1 32
  • 34 (a)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ADL013C 30
  • 46.46 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAS2 30 31 33
  • 46.06 (n)
OneToMany
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D14135g 30
  • 45.97 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT5G57950 30
  • 42.81 (n)
Rice
(Oryza sativa)
Liliopsida Os09g0420600 30
  • 44.62 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU11053 30
  • 49 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 44 (a)
OneToMany
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC2H10.02c 30
  • 42.31 (n)
Species where no ortholog for PSMD9 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)