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The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1. [provided by RefSeq, Jul 2008]
PSMD8 (Proteasome 26S Subunit, Non-ATPase 8) is a Protein Coding gene. Diseases associated with PSMD8 include Cystic Fibrosis. Among its related pathways are Downstream signaling events of B Cell Receptor (BCR) and CDK-mediated phosphorylation and removal of Cdc6.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 29290612 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000502 | proteasome complex | TAS,IDA | 17323924 |
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0005838 | proteasome regulatory particle | TAS | 7621825 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | CDK-mediated phosphorylation and removal of Cdc6 |
.93
.93
|
.80
.80
.78
.70
.47
.31
|
2 | RET signaling |
.92
|
.92
|
3 | HIV Life Cycle |
.64
|
.45
|
4 | Pathways of neurodegeneration - multiple diseases | ||
5 | Class I MHC mediated antigen processing and presentation |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000165 | MAPK cascade | TAS | -- |
GO:0000209 | protein polyubiquitination | TAS | -- |
GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
GO:0006508 | proteolysis | IEA | -- |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||||
SP5: | - | ||||||||||||||||||||||||||||||||||
SP6: | - | - | - | ||||||||||||||||||||||||||||||||
SP7: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PSMD8 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Cow (Bos Taurus) |
Mammalia | PSMD8 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PSMD8 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Psmd8 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Psmd8 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | PSMD8 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | PSMD8 31 |
|
OneToOne | |
African clawed frog (Xenopus laevis) |
Amphibia | Xl.3601 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | psmd8 30 31 |
|
OneToOne | |
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9469 30 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002606 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Rpn12 30 31 32 |
|
OneToMany | |
Rpn12R 31 |
|
OneToMany | |||
CG11552 32 |
|
|
|||
Worm (Caenorhabditis elegans) |
Secernentea | rpn-12 30 31 |
|
OneToOne | |
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AFR278W 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RPN12 30 31 33 |
|
OneToOne | |
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0D11374g 30 |
|
||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | RPN12a 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os07g0435100 30 |
|
||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU10067 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rpn12 30 |
|
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs141504927 | Benign: not provided | 38,380,925(+) |
A/G NM_002812.4(PSMD8):c.729A>G (p.Lys243=) |
SYNONYMOUS | |
rs201665089 | Benign: not provided | 38,374,779(+) |
G/A NM_002812.4(PSMD8):c.178G>A (p.Ala60Thr) |
MISSENSE | |
rs28384479 | Benign: not provided | 38,374,946(+) |
G/A NM_002812.4(PSMD8):c.345G>A (p.Glu115=) |
SYNONYMOUS |