Aliases for PSMD8 Gene
Aliases for PSMD8 Gene
- Proteasome 26S Subunit, Non-ATPase 8 2 3 5
- Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 8 2 3
- 26S Proteasome Regulatory Subunit RPN12 3 4
- 26S Proteasome Regulatory Subunit S14 3 4
- P31 3 4
- Epididymis Secretory Sperm Binding Protein Li 91n 3
- 26S Proteasome Non-ATPase Regulatory Subunit 8 3
- 26S Proteasome Regulatory Subunit P31 3
External Ids for PSMD8 Gene
- HGNC: 9566
- Entrez Gene: 5714
- Ensembl: ENSG00000099341
- UniProtKB: P48556
Previous GeneCards Identifiers for PSMD8 Gene
- GC19P039479
- GC19P039256
- GC19P043541
- GC19P043558
- GC19P043559
- GC19P043560
- GC19P038865
- GC19P035312
Summaries for PSMD8 Gene
-
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1. [provided by RefSeq, Jul 2008]
GeneCards Summary for PSMD8 Gene
PSMD8 (Proteasome 26S Subunit, Non-ATPase 8) is a Protein Coding gene. Among its related pathways are RET signaling and CDK-mediated phosphorylation and removal of Cdc6.
UniProtKB/Swiss-Prot for PSMD8 Gene
-
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
Additional gene information for PSMD8 Gene
- Monarch Initiative
- Search for PSMD8 at DataMed
- Search for PSMD8 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMD8 Gene
Genomics for PSMD8 Gene
GeneHancer (GH) Regulatory Elements for PSMD8 Gene
Promoters and enhancers for PSMD8 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PSMD8 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for PSMD8 Gene
Genomic Locations for PSMD8 Gene
- chr19:38,374,536-38,383,824
- (GRCh38/hg38)
- Size:
- 9,289 bases
- Orientation:
- Plus strand
- chr19:38,865,176-38,874,464
- (GRCh37/hg19)
Genomic View for PSMD8 Gene
Genes around PSMD8 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.2 by Ensembl
- 19q13.2 by Entrez Gene
- 19q13.2 by HGNC
PSMD8 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PSMD8 Gene
Proteins for PSMD8 Gene
-
Protein details for PSMD8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P48556-PSMD8_HUMAN
- Recommended name:
- 26S proteasome non-ATPase regulatory subunit 8
- Protein Accession:
- P48556
- B4DX18
- Q6P1L7
Protein attributes for PSMD8 Gene
- Size:
- 350 amino acids
- Molecular mass:
- 39612 Da
- Quaternary structure:
-
- Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD8, a base containing 6 ATPases and few additional components.
- SequenceCaution:
-
- Sequence=AAC62833.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAH01164.3; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH65006.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA07237.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for PSMD8 Gene
Post-translational modifications for PSMD8 Gene
Other Protein References for PSMD8 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for PSMD8
-
Abcam antibodies for PSMD8
- Invitrogen Antibodies for PSMD8
- GeneTex PSMD8 antibody for PSMD8
-
Santa Cruz Biotechnology (SCBT) Antibodies for PSMD8
Protein Products
-
OriGene Purified Proteins for PSMD8
- Search Origene for MassSpec and Protein Over-expression Lysates for PSMD8
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-
Abcam proteins for PSMD8
Assay Products
No data available for DME Specific Peptides for PSMD8 Gene
Domains & Families for PSMD8 Gene
Gene Families for PSMD8 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for PSMD8 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PSMD8 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P48556- Family:
-
- Belongs to the proteasome subunit S14 family.
Function for PSMD8 Gene
Molecular function for PSMD8 Gene
- UniProtKB/Swiss-Prot Function:
- Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
Phenotypes From GWAS Catalog for PSMD8 Gene
Phenotypes for PSMD8 Gene
- GenomeRNAi human phenotypes for PSMD8:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased viability
- Decreased hepcidin::fluc mRNA expression
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased shRNA abundance (Z-score < -2)
- Dynamic nuclei (hole, folded or small irregular)
- Decreased NF-kappaB reporter expression
- FOXO1 nuclear localization
- Increased shRNA abundance (Z-score > 2)
- Increased G1 DNA content
- Effect on mitosis
- Decreased homologous recombination repair frequency
- Increased cell death HMECs cells
- Synthetic lethal with vaccinia virus (VACV) infection
- Decreased cell number
- Decreased viability of wild-type and TP53 knockout cells
- Increased Sindbis virus (SINV) infection
- HIV Rev nuclear localization
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for PSMD8 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PSMD8 gene
- Search ViGene Biosciences for PSMD8
CRISPR Products
-
OriGene CRISPR knockouts for PSMD8
- genomics-online: gRNA clones - Search results for available PSMD8 gene related products
- Applied Biological Materials CRISPR for PSMD8
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSMD8
- GenScript: Design CRISPR guide RNA sequences for PSMD8
miRNA for PSMD8 Gene
- miRTarBase miRNAs that target PSMD8
miRNA Products
- Search ViGene Biosciences for PSMD8
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PSMD8
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-
ViGene Biosciences ready-to-package AAV shRNAs for PSMD8 gene
Clone Products
- Sino Biological Human cDNA Clone for PSMD8
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available PSMD8 gene related products
- orf clones - Search results for available PSMD8 gene related products
- Applied Biological Materials Clones for PSMD8
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for PSMD8 gene
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ViGene Biosciences lentiviral particle packaged cDNA for PSMD8 gene
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No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMD8 Gene
Localization for PSMD8 Gene
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 5 |
| mitochondrion | 2 |
| plasma membrane | 1 |
| peroxisome | 1 |
| golgi apparatus | 1 |
- Cytosol (2)
- Nuclear speckles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000502 | proteasome complex | IDA,TAS | 17323924 |
| GO:0005634 | nucleus | HDA,IDA | 21630459 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005829 | cytosol | TAS,IBA | -- |
| GO:0005838 | proteasome regulatory particle | TAS | 7621825 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for PSMD8 Gene
Pathways & Interactions for PSMD8 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | CDK-mediated phosphorylation and removal of Cdc6 |
.93
.93
|
.80
.78
.78
.70
.47
.31
|
| 2 | RET signaling |
.92
|
.92
|
| 3 | HIV Life Cycle |
.65
|
.45
|
| 4 | Class I MHC mediated antigen processing and presentation | ||
| 5 | Antigen processing-Cross presentation | ||
Pathways by source for PSMD8 Gene
1 Sino Biological pathway for PSMD8 Gene
2 BioSystems pathways for PSMD8 Gene
2 KEGG pathways for PSMD8 Gene
3 GeneGo (Thomson Reuters) pathways for PSMD8 Gene
2 Qiagen pathways for PSMD8 Gene
Interacting Proteins for PSMD8 Gene
Selected Interacting proteins:
ENSP00000215071
P48556-PSMD8_HUMAN
for PSMD8 Gene via
STRING
MINT
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
| GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
| GO:0006508 | proteolysis | IEA | -- |
No data available for SIGNOR curated interactions for PSMD8 Gene
Drugs & Compounds for PSMD8 Gene
Transcripts for PSMD8 Gene
mRNA/cDNA for PSMD8 Gene
- (1) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (841) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PSMD8 Gene
CRISPR Products
-
OriGene CRISPR knockouts for PSMD8
- genomics-online: gRNA clones - Search results for available PSMD8 gene related products
- Applied Biological Materials CRISPR for PSMD8
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSMD8
- GenScript: Design CRISPR guide RNA sequences for PSMD8
miRNA Products
- Search ViGene Biosciences for PSMD8
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PSMD8
- Browse OriGene Inhibitory RNA Products For PSMD8
- genomics-online: shRNA clones - Search results for available PSMD8 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PSMD8 gene
Clone Products
- Sino Biological Human cDNA Clone for PSMD8
- VectorBuilder custom plasmid, inducible vectors for PSMD8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PSMD8
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available PSMD8 gene related products
- orf clones - Search results for available PSMD8 gene related products
- Applied Biological Materials Clones for PSMD8
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | ||||||||||||||||||||||||||||||||
| SP7: |
Expression for PSMD8 Gene
mRNA differential expression in normal tissues according to GTEx for PSMD8 Gene
This gene is overexpressed in Muscle - Skeletal (x4.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PSMD8 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of PSMD8 Gene:
PSMD8SOURCE GeneReport for Unigene cluster for PSMD8 Gene:
Hs.78466Evidence on tissue expression from TISSUES for PSMD8 Gene
- Skin(4.7)
- Muscle(4.5)
- Blood(4.2)
- Nervous system(4)
- Lung(3.8)
- Intestine(3.7)
- Pancreas(2.8)
- Liver(2.1)
- Heart(2)
Primer Products
-
OriGene qPCR primer pairs for PSMD8
-
OriGene qPCR primer pairs and template standards for PSMD8
- genomics-online: primer clones - Search results for available PSMD8 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMD8 Gene
Orthologs for PSMD8 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PSMD8 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | PSMD8 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | PSMD8 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Psmd8 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Psmd8 33 16 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | PSMD8 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | PSMD8 34 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.3601 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | psmd8 33 34 |
|
||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9469 33 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002606 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Rpn12 35 33 34 |
|
||
| CG11552 35 |
|
|
|||
| Rpn12R 34 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | rpn-12 33 34 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AFR278W 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RPN12 33 34 36 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0D11374g 33 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | RPN12a 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os07g0435100 33 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU10067 33 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rpn12 33 |
|
- Species where no ortholog for PSMD8 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for PSMD8 Gene
(3) SIMAP similar genes for PSMD8 Gene using alignment to 7 proteins:
Pseudogenes.org Pseudogenes for PSMD8 Gene
No data available for Paralogs for PSMD8 Gene
Variants for PSMD8 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000158263 | -- | 38,375,171(+) | A/G | intron_variant | |
| rs1000594222 | -- | 38,376,479(+) | T/G | intron_variant | |
| rs1000758919 | -- | 38,376,681(+) | G/A | intron_variant | |
| rs1001307795 | -- | 38,377,163(+) | C/T | intron_variant | |
| rs1001683632 | -- | 38,384,158(+) | T/C | downstream_transcript_variant |
Gene Damage Index Score:
1.56;
30.18% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PSMD8 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PSMD8
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMD8 Gene
Disorders for PSMD8 Gene
Additional Disease Information for PSMD8
No disorders were found for PSMD8 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMD8 Gene
Publications for PSMD8 Gene
- Nin1p, a regulatory subunit of the 26S proteasome, is necessary for activation of Cdc28p kinase of Saccharomyces cerevisiae. (PMID: 7621825) Kominami K … Shimizu Y (The EMBO journal 1995) 2 3 4 58
- Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X … Huang L (Biochemistry 2007) 3 4 58
- The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- An Interaction Landscape of Ubiquitin Signaling. (PMID: 28190767) Zhang X … Vermeulen M (Molecular cell 2017) 3 58
Products for PSMD8 Gene
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 43 available PSMD8 Antibodies ranked by validation data
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- GeneTex PSMD8 antibody for PSMD8
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- ViGene Biosciences adenoviral particle packaged cDNA for PSMD8 gene
- ViGene Biosciences lentiviral particle packaged cDNA for PSMD8 gene
- ViGene Biosciences ready-to-package AAV shRNAs for PSMD8 gene