PSMD5 Gene (Protein Coding)

Proteasome 26S Subunit, Non-ATPase 5

GCID:: GC09M120815

GIFtS:: 39

Genes Participants

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 n... See more...

Aliases for PSMD5 Gene

Proteasome 26S Subunit, Non-ATPase 5 ² ³ ⁵
Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 5 ² ³
26S Proteasome Non-ATPase Regulatory Subunit 5 ³ ⁴
26S Protease Subunit S5 Basic ³ ⁴
26S Proteasome Subunit S5B ³ ⁴
KIAA0072 ⁴
S5B ³

External Ids for PSMD5 Gene

HGNC: 9563
Entrez Gene: 5711
Ensembl: ENSG00000095261
OMIM: 604452
UniProtKB: Q16401

Previous GeneCards Identifiers for PSMD5 Gene

GC09M114682
GC09M115224
GC09M117031
GC09M118954
GC09M120657
GC09M122617
GC09M123577
GC09M093196

Search aliases for PSMD5 gene in PubMed and other databases

Summaries for PSMD5 Gene

Entrez Gene Summary for PSMD5 Gene

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a non-ATPase subunit of the 19S regulator base that functions as a chaperone protein during 26S proteasome assembly. [provided by RefSeq, Jul 2012]

GeneCards Summary for PSMD5 Gene

PSMD5 (Proteasome 26S Subunit, Non-ATPase 5) is a Protein Coding gene. Diseases associated with PSMD5 include Splenic Manifestation Of Leukemia and Localized Pulmonary Fibrosis. Among its related pathways are Metabolism of proteins and RET signaling. Gene Ontology (GO) annotations related to this gene include binding and protein binding involved in protein folding.

UniProtKB/Swiss-Prot Summary for PSMD5 Gene

Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5.
- PSMD5_HUMAN,Q16401

Gene Wiki entry for PSMD5 Gene

Additional gene information for PSMD5 Gene

Search for PSMD5 at DataMed
Search for PSMD5 at HumanCyc

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSMD5 Gene

Genomics for PSMD5 Gene

GeneHancer (GH) Regulatory Elements for PSMD5 Gene

Promoters and enhancers for PSMD5 Gene

GeneHancer (GH) Identifier	GH Type	GH Score	GH Sources	Gene Association Score	Total Score	TSS distance (kb)	Number of Genes Away	Size (kb)	Transcription Factor Binding Sites
GH09J120841	Promoter/Enhancer	2	EPDnew Ensembl ENCODE CraniofacialAtlas	516.2	+0.0	20	2.8	FOXK2 ZNF217 EP300 TCF12 POLR2G PHF8 TEAD4 ZFX POLR2A CLOCK	PSMD5 piR-41780 CUTALP FBXW2 ENSG00000239593 lnc-PHF19-1 lnc-B3GNT10-21
GH09J120791	Promoter/Enhancer	2.2	EPDnew Ensembl ENCODE CraniofacialAtlas	49	+50.1	50106	3.8	RXRA HNRNPK ZBTB40 ZNF217 TCF12 POLR2G SP1 GTF2E2 PHF8 PHB2	FBXW2 B3GNT10 lnc-CNTRL-2 lnc-PSMD5-3 piR-36171 PSMD5 CUTALP CNTRL
GH09J120918	Promoter/Enhancer	2.6	EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER	16.9	-85.5	-85541	20.1	ZBTB40 CTCF SIN3A NRF1 TCF12 USF1 POLR2G SP1 FOS ZFX	TRAF1 piR-56037-112 CUTALP PSMD5 FBXW2 B3GNT10 HSALNG0074148 PHF19 lnc-C5-1
GH09J120965	Enhancer	1	Ensembl ENCODE dbSUPER	33.5	-122.8	-122780	2.8	EP300 ZNF623 ZNF510 RFX1 ZNF316 YY1 ZBTB11 ZNF426 ZNF213 ZFP64	PSMD5 CUTALP CNTRL FBXW2 TRAF1 GGTA1P C5 piR-41195-125 C5-OT1-001 lnc-C5-1
GH09J121397	Enhancer	1.2	FANTOM5 Ensembl ENCODE	25.6	-555.9	-555880	3.4	CTCF FOS ZNF623 AFF1 REST TOE1 RAD21 TRIM22 TEAD1 ZEB1	GGTA1P PSMD5 FBXW2 MRRF ENSG00000227355 CNTRL STOM GSN-AS1 ENSG00000239593 GSN

- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSMD5 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PSMD5

Top Transcription factor binding sites by QIAGEN in the PSMD5 gene promoter:

AP-1
CHOP-10
HOXA9
HOXA9B
Meis-1
Meis-1a
Nkx6-1
p53
Pax-5
STAT3

Genomic Locations for PSMD5 Gene

chr9:120,814,779-120,843,021: (GRCh38/hg38)

Size:: 28,243 bases
Orientation:: Minus strand

chr9:123,577,774-123,605,262: (GRCh37/hg19)

Size:: 27,489 bases
Orientation:: Minus strand

Genomic View for PSMD5 Gene

Genes around PSMD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:

9q33.2 by HGNC
9q33.2 by Entrez Gene
9q33.2 by Ensembl

PSMD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

Genomic Location for PSMD5 Gene — Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PSMD5 Gene

NC_000009.12

Proteins for PSMD5 Gene

Protein details for PSMD5 Gene (UniProtKB/Swiss-Prot)
Protein Symbol:

Q16401-PSMD5_HUMAN

Recommended name:

26S proteasome non-ATPase regulatory subunit 5

Protein Accession:

Q16401

Secondary Accessions:
- B4DZM8
- Q15045
- Q4VXG8
Protein attributes for PSMD5 Gene
Size:

504 amino acids

Molecular mass:

56196 Da
Quaternary structure:
Interacts with PSMC1, PSMC2, PSMD1 and PSMD6. Part of transient complex containing PSMD5, PSMC2, PSMC1 and PSMD2 formed during the assembly of the 26S proteasome.
Alternative splice isoforms for PSMD5 Gene
UniProtKB/Swiss-Prot:
Q16401-1

Q16401-2

neXtProt entry for PSMD5 Gene

Protein Expression for PSMD5 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for PSMD5 Gene

Ubiquitination at Lys143, Lys147, and Lys467
- NX_Q16401 (NX_Q16401-1)
Modification sites at PhosphoSitePlus
- Q16401

Other Protein References for PSMD5 Gene

ENSEMBL proteins:

REFSEQ proteins:

Antibody Products

Creative Diagnostics Anti-PSMD5 (aa 1-264) polyclonal antibody

Creative Biolabs Recombinant Anti-Human PSMD5 Antibody

GeneTex Anti-PSMD5 antibody [N1C1]

OriGene Antibodies for PSMD5
- TA324261
- TA324262
- TA332079
- TA811921
- TA811921S
Custom Antibody Services

Novus Biologicals Antibodies for PSMD5

Abcam antibodies for PSMD5
- Proteasome 26S S5

Invitrogen Antibodies for PSMD5 (AFLGC-PSMD5)

Biorbyt antibodies for PSMD5
- orb353488
- orb541177

Browse Boster Bio Antibodies

Santa Cruz Biotechnology (SCBT) Antibodies for PSMD5
- PSMD5 (35-K)
- PSMD5 (D-11)

Browse Sino Biological Antibodies

Protein Products

OriGene Purified Proteins for PSMD5
- NM_005047
- NM_005047
- NM_005047
- NM_005047
- NM_080554
Search Origene for MassSpec and Protein Over-expression Lysates for PSMD5
Origene Custom Protein Services for PSMD5

Novus Biologicals proteins and lysates for PSMD5

ProSpec Recombinant Proteins for PSMD5

antibodies-online: Show 9 available PSMD5 Proteins ranked by validation data
Compare Top PSMD5 Proteins

Search for PSMD5 Proteins at Signalway

Search for PSMD5 Proteins at ProSci

Abcam proteins for PSMD5
- Proteasome 26S S5

Assay Products

antibodies-online: Search results for available PSMD5 related products ranked by validation data

Browse Boster Bio ELISA Kits

Search for PSMD5 ELISA kits at Signalway

Browse Sino Biological Assays

No data available for DME Specific Peptides for PSMD5 Gene

Domains & Families for PSMD5 Gene

Gene Families for PSMD5 Gene

HGNC:

Human Protein Atlas (HPA):

Plasma proteins
Predicted intracellular proteins

Protein Domains for PSMD5 Gene

InterPro:

ProtoNet:

Q16401

Suggested Antigen Peptide Sequences for PSMD5 Gene

GenScript: Design optimal peptide antigens:

cDNA FLJ52877, highly similar to 26S proteasome non-ATPase regulatory subunit 5 (B4DZM8_HUMAN)
26S proteasome subunit S5B (PSMD5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16401

UniProtKB/Swiss-Prot:

PSMD5_HUMAN :

Rich in dileucine repeats, which have been implicated in trafficking of a variety of transmembrane proteins.
Belongs to the proteasome subunit S5B/HSM3 family.

Domain:

Rich in dileucine repeats, which have been implicated in trafficking of a variety of transmembrane proteins.

Family:

Belongs to the proteasome subunit S5B/HSM3 family.

Function for PSMD5 Gene

Molecular function for PSMD5 Gene

UniProtKB/Swiss-Prot Function:

Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5.

PSMD5_HUMAN,Q16401

Phenotypes From GWAS Catalog for PSMD5 Gene

Gene Ontology (GO) - Molecular Function for PSMD5 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	16189514

Phenotypes for PSMD5 Gene

MGI mutant phenotypes for PSMD5:

inferred from 1 alleles

GenomeRNAi human phenotypes for PSMD5:

Animal Models for PSMD5 Gene

MGI Knock Outs for PSMD5:

Psmd5 ^{Psmd5<tm1b(EUCOMM)Wtsi>}

Animal Model Products

Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study

CRISPR Products

Applied Biological Materials (abm): CRISPR Clones for PSMD5 - Select products 50% OFF >
* PSMD5 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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OriGene CRISPR knockouts for PSMD5
- GA103879
- GA207074
- KN404913
- KN514124

Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PSMD5

genomics-online: gRNA clones - Search for available PSMD5 gRNA products
Overview of 132 available PSMD5 gene related products
Recommended
- pCMV-SPORT6
- pOTB7
- pExpress-1
- pGEM-T
- pUC19
- pORF
- pDONR223
- pPM-C-HA
- pPM-C-His
- pPB-N-His
- pPB-His-MBP
- pPB-C-His
- pPB-His-GST
- pENTR221

Santa Cruz Biotechnology (SCBT) CRISPR for PSMD5

miRNA for PSMD5 Gene

miRTarBase miRNAs that target PSMD5

miRNA Products

Search GeneCopoeia for miRNA 3'UTR Target clone products for PSMD5

Browse OriGene miRNA Products For PSMD5

Inhibitory RNA Products

Origene shrna, sirna, and RNAi products in human, mouse, rat for PSMD5
Browse OriGene Inhibitory RNA Products For PSMD5

Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMD5

genomics-online: shRNA clones - Search for available PSMD5 shRNA products
Overview of 132 available PSMD5 gene related products
Recommended
- pCMV-SPORT6
- pOTB7
- pExpress-1
- pGEM-T
- pUC19
- pORF
- pDONR223
- pPM-C-HA
- pPM-C-His
- pPB-N-His
- pPB-His-MBP
- pPB-C-His
- pPB-His-GST
- pENTR221

Search Santa Cruz Biotechnology (SCBT) for PSMD5 siRNA/shRNA

Clone Products

Applied Biological Materials (abm): Clones for PSMD5 - Select products 50% OFF >
* PSMD5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
* Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All

OriGene clones in human,mouse,rat for PSMD5
- SC216846
- MC206361
- MC217173
- RN214874
- SC101418
- SC321629
- SC330831
OriGene ORF clones in human,mouse,rat for PSMD5
- MG208111
- MR208111
- MR208111L3
- MR208111L4
- RC204913
- RC204913L1
- RC204913L2
- RC204913L3
- RC204913L4
- RC232790
- RG204913
- RG232790
- RR214874
- RR214874L3
- RR214874L4
- MR208111L3V
- MR208111L4V
- RC204913L1V
- RC204913L2V
- RC204913L3V
- RC204913L4V
- RR214874L3V
- RR214874L4V
Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling

Sino Biological Human cDNA Clone for PSMD5

Search Addgene for plasmids for PSMD5

Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PSMD5

genomics-online: cdna clones - Search for available PSMD5 CDNA products
Overview of 132 available PSMD5 gene related products
Recommended
- pCMV-SPORT6
- pOTB7
- pExpress-1
- pGEM-T
- pUC19
- pORF
- pDONR223
- pPM-C-HA
- pPM-C-His
- pPB-N-His
- pPB-His-MBP
- pPB-C-His
- pPB-His-GST
- pENTR221
orf clones - Search for available PSMD5 ORF products
Overview of 132 available PSMD5 gene related products
Recommended
- pCMV-SPORT6
- pOTB7
- pExpress-1
- pGEM-T
- pUC19
- pORF
- pDONR223
- pPM-C-HA
- pPM-C-His
- pPB-N-His
- pPB-His-MBP
- pPB-C-His
- pPB-His-GST
- pENTR221

Cell Line Products

Browse ESI BIO Cell Lines and PureStem Progenitors for PSMD5

Browse GeneCopoeia Cell Lines

VectorBuilder Stable cell line generation for PSMD5

Horizon Cell Lines for PSMD5
- PSMD5 knockout cell line

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PSMD5 Gene

Localization for PSMD5 Gene

Subcellular locations from

COMPARTMENTS

Compartment	Confidence
nucleus	5
cytosol	5
cytoskeleton	4
plasma membrane	3
extracellular	3
mitochondrion	3
peroxisome	2
endoplasmic reticulum	2
endosome	2
lysosome	2
golgi apparatus	2

Subcellular locations from the

Human Protein Atlas (HPA)

Cytosol (2)
Nucleoplasm (2)

See all subcellular structures

Gene Ontology (GO) - Cellular Components for PSMD5 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000502	proteasome complex	TAS	8811196
GO:0005654	nucleoplasm	TAS	--
GO:0005829	cytosol	TAS	--
GO:0008540	colocalizes_with proteasome regulatory particle, base subcomplex	IBA,IDA	19412159
GO:0022624	proteasome accessory complex	ISS	--

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PSMD5 Gene

Pathways & Interactions for PSMD5 Gene

SuperPathways for PSMD5 Gene

	SuperPathway	Contained pathways
1	CDK-mediated phosphorylation and removal of Cdc6	Activation of APC/C and APC/C-Cdc20 mediated degradation of mitotic proteins .95 Cdc20-Phospho-APC/C mediated degradation of Cyclin A .95 Autodegradation of the E3 ubiquitin ligase COP1 .95 Stabilization of p53 .95 Regulation of activated PAK-2p34 by proteasome mediated degradation .94 Regulation of Apoptosis .94 CDK-mediated phosphorylation and removal of Cdc6 .94 Ubiquitin-dependent degradation of Cyclin D .94 Ubiquitin-dependent degradation of Cyclin D1 .94 Orc1 removal from chromatin .94 Regulation of DNA replication .94 Switching of origins to a post-replicative state .94 Cyclin A-Cdk2-associated events at S phase entry .93 Cyclin E associated events during G1/S transition .93 APC/C-Cdc20 mediated degradation of Securin .93 APC/C-Cdh1 mediated degradation of Cdc20 and other APC/C-Cdh1 targeted proteins in late mitosis/early G1 .93 APC/C-mediated degradation of cell cycle proteins .93 Regulation of APC/C activators between G1/S and early anaphase .93 Regulation of mitotic cell cycle .93 DNA Replication .93 Synthesis of DNA .93 Vpu mediated degradation of CD4 .93 Autodegradation of Cdh1 by Cdh1-APC/C .91 SCF-beta-TrCP mediated degradation of Emi1 .91 p53-Independent DNA Damage Response .91 p53-Independent G1/S DNA damage checkpoint .91 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A .91 ABC transporter disorders .91 Disorders of transmembrane transporters .91 Defective CFTR causes cystic fibrosis .90 Assembly of the pre-replicative complex .90 Hedgehog ligand biogenesis .90 Hh mutants abrogate ligand secretion .90 APC/C-Cdc20 mediated degradation of mitotic proteins .89 APC-Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint .89 Vif-mediated degradation of APOBEC3G .89 Degradation of GLI1 by the proteasome .89 Degradation of GLI2 by the proteasome .89 GLI3 is processed to GLI3R by the proteasome .89	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis .88 Degradation of AXIN .88 Cellular response to hypoxia .87 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha .87 Regulation of Hypoxia-inducible Factor (HIF) by oxygen .87 CDT1 association with the CDC6-ORC-origin complex .87 Hh mutants that dont undergo autocatalytic processing are degraded by ERAD .87 AUF1 (hnRNP D0) binds and destabilizes mRNA .86 p53-Dependent G1 DNA Damage Response .86 p53-Dependent G1/S DNA damage checkpoint .86 SCF(Skp2)-mediated degradation of p27/p21 .86 Removal of licensing factors from origins .86 NIK-->noncanonical NF-kB signaling .85 Dectin-1 mediated noncanonical NF-kB signaling .84 G1/S DNA Damage Checkpoints .84 Degradation of DVL .83 Cross-presentation of soluble exogenous antigens (endosomes) .82 The role of GTSE1 in G2/M progression after G2 checkpoint .81 Regulation of ornithine decarboxylase (ODC) .81 DNA Replication Pre-Initiation .80 M/G1 Transition .80 S Phase .78 Activation of NF-kappaB in B cells .77 Asymmetric localization of PCP proteins .74 FCERI mediated NF-kB activation .72 Regulation of RAS by GAPs .70 PCP/CE pathway .70 Beta-catenin independent WNT signaling .64 Degradation of beta-catenin by the destruction complex .64 Regulation of mRNA stability by proteins that bind AU-rich elements .63 Metabolism of polyamines .60 ABC-family proteins mediated transport .58 TNFR2 non-canonical NF-kB pathway .58 MAPK6/MAPK4 signaling .57 Proteasome Degradation .56 UCH proteinases .47 Canonical Wnt Pathway .32 Apoptosis .31 Programmed Cell Death .31
2	RET signaling	Frs2-mediated activation .95 GRB2 events in EGFR signaling .95 MAPK1/MAPK3 signaling .95 Prolonged ERK activation events .95 RAF/MAP kinase cascade .95 SHC1 events in EGFR signaling .95 Signaling by Leptin .95 SOS-mediated signalling .95 VEGFR2 mediated cell proliferation .95 ARMS-mediated activation .95 Signalling to ERKs .95 Signalling to p38 via RIT and RIN .95 Signalling to RAS .95 Interleukin receptor SHC signaling .95 Interleukin-3, 5 and GM-CSF signaling .94 Interleukin-2 signaling .94 Downstream signal transduction .94 Signaling by PDGF .94 DAP12 signaling .92	RET signaling .92 Insulin receptor signalling cascade .92 Signaling by Insulin receptor .92 IRS-mediated signalling .91 Signaling by EGFR .90 FCERI mediated MAPK activation .90 IGF1R signaling cascade .90 IRS-related events triggered by IGF1R .90 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) .90 DAP12 interactions .89 NCAM signaling for neurite out-growth .89 NGF signalling via TRKA from the plasma membrane .87 MAPK family signaling cascades .87 Signaling by SCF-KIT .85 Signalling by NGF .81 Fc epsilon receptor (FCERI) signaling .79 VEGFA-VEGFR2 Pathway .78 Signaling by VEGF .76 Gastrin-CREB signalling pathway via PKC and MAPK .55
3	Chks in Checkpoint Regulation	Chks in Checkpoint Regulation .59 G2-M Phase Transition .59 Estrogen-mediated S-Phase Entry .55	SREBP Proteolysis .43 DNA Repair Mechanisms .32 Parkinson's Disease Pathway .31
4	HIV Life Cycle	HIV Infection .64 Infectious disease .61 Host Interactions of HIV factors .57	Disease .45 Diseases of signal transduction .43
5	Class I MHC mediated antigen processing and presentation	Antigen processing- Ubiquitination and Proteasome degradation .83 Class I MHC mediated antigen processing and presentation .83	Adaptive Immune System .45

Pathways by source for PSMD5 Gene

1 Sino Biological pathway for PSMD5 Gene

Canonical Wnt Pathway

2 BioSystems pathways for PSMD5 Gene

164 Reactome pathways for PSMD5 Gene

3 GeneGo (Thomson Reuters) pathways for PSMD5 Gene

Immune response Antigen presentation by MHC class I
Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
Transcription Ligand-Dependent Transcription of Retinoid-Target genes

19 Qiagen pathways for PSMD5 Gene

CDK5 Pathway
Chks in Checkpoint Regulation
DNA Repair Mechanisms
Estrogen-mediated S-Phase Entry
G2-M Phase Transition

Interacting Proteins for PSMD5 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)

Selected Interacting proteins: Q16401-PSMD5_HUMAN ENSP00000210313 for PSMD5 Gene via UniProtKB MINT STRING IID

Symbol	External ID(s)	Details
PSMC2	P35998 ⁴ ²⁰ ¹²⁷ ENSP00000391211 ²¹	EBI-752143, EBI-359710 MINT-8166071 STRING: ENSP00000391211 IID: # exp=11 # pred=4
ABRAXAS2	Q15018 ²⁰ ¹²⁷ ENSP00000298492 ²¹	MINT-7230300 STRING: ENSP00000298492 IID: # exp=1
PSMC1	P62191 ⁴ ¹²⁷ ENSP00000261303 ²¹	EBI-752143, EBI-357598 STRING: ENSP00000261303 IID: # exp=8 # pred=3
TP53	P04637 ²⁰ ¹²⁷ ENSP00000269305 ²¹	MINT-8415512 STRING: ENSP00000269305 IID: # exp=1
ADRM1	ENSP00000478877 ²¹ Q16186 ¹²⁷	STRING: ENSP00000478877 IID: # exp=2 # pred=1

GPS-Prot Interaction Network for PSMD5

;

Gene Ontology (GO) - Biological Process for PSMD5 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000165	MAPK cascade	TAS	--
GO:0000209	protein polyubiquitination	TAS	--
GO:0002223	stimulatory C-type lectin receptor signaling pathway	TAS	--
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	TAS	--
GO:0006521	regulation of cellular amino acid metabolic process	TAS	--

No data available for SIGNOR curated interactions for PSMD5 Gene

Drugs & Compounds for PSMD5 Gene

(2) Drugs for PSMD5 Gene - From: DGIdb

Name	Status	Disease Links	Group	Role	Mechanism of Action	Clinical Trials
Bortezomib	Approved, Investigational	MalaCards Medline Plus	Pharma	inhibitor, other	Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors	888
carfilzomib	Approved, Investigational	MalaCards Medline Plus	Pharma	other, Inhibitor	Other, 20S Proteasome Inhibitor	0

Drug Products

Browse Tocris compounds for PSMD5

Browse compounds at ApexBio

Transcripts for PSMD5 Gene