The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 n... See more...

Aliases for PSMD5 Gene

Aliases for PSMD5 Gene

  • Proteasome 26S Subunit, Non-ATPase 5 2 3 5
  • Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 5 2 3
  • 26S Proteasome Non-ATPase Regulatory Subunit 5 3 4
  • 26S Protease Subunit S5 Basic 3 4
  • 26S Proteasome Subunit S5B 3 4
  • KIAA0072 4
  • S5B 3

External Ids for PSMD5 Gene

Previous GeneCards Identifiers for PSMD5 Gene

  • GC09M114682
  • GC09M115224
  • GC09M117031
  • GC09M118954
  • GC09M120657
  • GC09M122617
  • GC09M123577
  • GC09M093196

Summaries for PSMD5 Gene

Entrez Gene Summary for PSMD5 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a non-ATPase subunit of the 19S regulator base that functions as a chaperone protein during 26S proteasome assembly. [provided by RefSeq, Jul 2012]

GeneCards Summary for PSMD5 Gene

PSMD5 (Proteasome 26S Subunit, Non-ATPase 5) is a Protein Coding gene. Diseases associated with PSMD5 include Splenic Manifestation Of Leukemia and Localized Pulmonary Fibrosis. Among its related pathways are Metabolism of proteins and RET signaling. Gene Ontology (GO) annotations related to this gene include binding and protein binding involved in protein folding.

UniProtKB/Swiss-Prot Summary for PSMD5 Gene

  • Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5.

Gene Wiki entry for PSMD5 Gene

Additional gene information for PSMD5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSMD5 Gene

Genomics for PSMD5 Gene

GeneHancer (GH) Regulatory Elements for PSMD5 Gene

Promoters and enhancers for PSMD5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSMD5 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PSMD5

Top Transcription factor binding sites by QIAGEN in the PSMD5 gene promoter:
  • AP-1
  • CHOP-10
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1a
  • Nkx6-1
  • p53
  • Pax-5
  • STAT3

Genomic Locations for PSMD5 Gene

Genomic Locations for PSMD5 Gene
chr9:120,814,779-120,843,021
(GRCh38/hg38)
Size:
28,243 bases
Orientation:
Minus strand
chr9:123,577,774-123,605,262
(GRCh37/hg19)
Size:
27,489 bases
Orientation:
Minus strand

Genomic View for PSMD5 Gene

Genes around PSMD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMD5 Gene

Proteins for PSMD5 Gene

  • Protein details for PSMD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16401-PSMD5_HUMAN
    Recommended name:
    26S proteasome non-ATPase regulatory subunit 5
    Protein Accession:
    Q16401
    Secondary Accessions:
    • B4DZM8
    • Q15045
    • Q4VXG8

    Protein attributes for PSMD5 Gene

    Size:
    504 amino acids
    Molecular mass:
    56196 Da
    Quaternary structure:
    • Interacts with PSMC1, PSMC2, PSMD1 and PSMD6. Part of transient complex containing PSMD5, PSMC2, PSMC1 and PSMD2 formed during the assembly of the 26S proteasome.

    Alternative splice isoforms for PSMD5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMD5 Gene

Post-translational modifications for PSMD5 Gene

  • Ubiquitination at Lys143, Lys147, and Lys467
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMD5 Gene

No data available for DME Specific Peptides for PSMD5 Gene

Domains & Families for PSMD5 Gene

Gene Families for PSMD5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PSMD5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PSMD5 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ52877, highly similar to 26S proteasome non-ATPase regulatory subunit 5 (B4DZM8_HUMAN)
  • 26S proteasome subunit S5B (PSMD5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16401

UniProtKB/Swiss-Prot:

PSMD5_HUMAN :
  • Rich in dileucine repeats, which have been implicated in trafficking of a variety of transmembrane proteins.
  • Belongs to the proteasome subunit S5B/HSM3 family.
Domain:
  • Rich in dileucine repeats, which have been implicated in trafficking of a variety of transmembrane proteins.
Family:
  • Belongs to the proteasome subunit S5B/HSM3 family.
genes like me logo Genes that share domains with PSMD5: view

Function for PSMD5 Gene

Molecular function for PSMD5 Gene

UniProtKB/Swiss-Prot Function:
Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5.

Phenotypes From GWAS Catalog for PSMD5 Gene

Gene Ontology (GO) - Molecular Function for PSMD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with PSMD5: view
genes like me logo Genes that share phenotypes with PSMD5: view

Animal Models for PSMD5 Gene

MGI Knock Outs for PSMD5:
  • Psmd5 Psmd5<tm1b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

miRNA for PSMD5 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PSMD5 Gene

Localization for PSMD5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMD5 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 4
plasma membrane 3
extracellular 3
mitochondrion 3
peroxisome 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PSMD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex TAS 8811196
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0008540 colocalizes_with proteasome regulatory particle, base subcomplex IBA,IDA 19412159
GO:0022624 proteasome accessory complex ISS --
genes like me logo Genes that share ontologies with PSMD5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PSMD5 Gene

Pathways & Interactions for PSMD5 Gene

PathCards logo

SuperPathways for PSMD5 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 Chks in Checkpoint Regulation
.59
.59
.55
.43
.32
.31
4 HIV Life Cycle
.45
5 Class I MHC mediated antigen processing and presentation
genes like me logo Genes that share pathways with PSMD5: view

Pathways by source for PSMD5 Gene

3 GeneGo (Thomson Reuters) pathways for PSMD5 Gene
  • Immune response Antigen presentation by MHC class I
  • Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
  • Transcription Ligand-Dependent Transcription of Retinoid-Target genes
19 Qiagen pathways for PSMD5 Gene
  • CDK5 Pathway
  • Chks in Checkpoint Regulation
  • DNA Repair Mechanisms
  • Estrogen-mediated S-Phase Entry
  • G2-M Phase Transition

Gene Ontology (GO) - Biological Process for PSMD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006521 regulation of cellular amino acid metabolic process TAS --
genes like me logo Genes that share ontologies with PSMD5: view

No data available for SIGNOR curated interactions for PSMD5 Gene

Drugs & Compounds for PSMD5 Gene

(2) Drugs for PSMD5 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 888
carfilzomib Approved, Investigational Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
genes like me logo Genes that share compounds with PSMD5: view

Transcripts for PSMD5 Gene

mRNA/cDNA for PSMD5 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMD5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c
SP1: - - - -
SP2:
SP3: -
SP4: - -
SP5:
SP6:

Relevant External Links for PSMD5 Gene

GeneLoc Exon Structure for
PSMD5

Expression for PSMD5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PSMD5 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMD5 Gene



Protein tissue co-expression partners for PSMD5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PSMD5

SOURCE GeneReport for Unigene cluster for PSMD5 Gene:

Hs.193725

Evidence on tissue expression from TISSUES for PSMD5 Gene

  • Liver(4.4)
  • Blood(4.2)
  • Bone marrow(4.2)
  • Skin(4.2)
  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with PSMD5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMD5 Gene

Orthologs for PSMD5 Gene

This gene was present in the common ancestor of animals.

Orthologs for PSMD5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMD5 31 30
  • 99.54 (n)
OneToOne
dog
(Canis familiaris)
Mammalia -- 31
  • 92 (a)
OneToMany
-- 31
  • 92 (a)
OneToMany
PSMD5 30
  • 90.11 (n)
cow
(Bos Taurus)
Mammalia PSMD5 31 30
  • 90.92 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psmd5 30
  • 87.7 (n)
mouse
(Mus musculus)
Mammalia Psmd5 17 31 30
  • 87.63 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PSMD5 31
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PSMD5 31
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves PSMD5 31 30
  • 73.88 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSMD5 31
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psmd5 30
  • 66.33 (n)
Str.5115 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.18176 30
zebrafish
(Danio rerio)
Actinopterygii psmd5 31 30
  • 58.99 (n)
OneToOne
Dr.15234 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13887 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001490 30
  • 40.64 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12096 31 30
  • 40.6 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11066 31
  • 32 (a)
OneToOne
Species where no ortholog for PSMD5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PSMD5 Gene

ENSEMBL:
Gene Tree for PSMD5 (if available)
TreeFam:
Gene Tree for PSMD5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PSMD5: view image

Paralogs for PSMD5 Gene

No data available for Paralogs for PSMD5 Gene

Variants for PSMD5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PSMD5 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs17282618 - p.Leu72His
rs2297575 - p.Glu21Gly

Additional dbSNP identifiers (rs#s) for PSMD5 Gene

Structural Variations from Database of Genomic Variants (DGV) for PSMD5 Gene

Variant ID Type Subtype PubMed ID
nsv1051370 CNV gain 25217958

Variation tolerance for PSMD5 Gene

Residual Variation Intolerance Score: 52.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.98; 68.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PSMD5 Gene

Human Gene Mutation Database (HGMD)
PSMD5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMD5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMD5 Gene

Disorders for PSMD5 Gene

MalaCards: The human disease database

(18) MalaCards diseases for PSMD5 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search PSMD5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PSMD5

genes like me logo Genes that share disorders with PSMD5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSMD5 Gene

Publications for PSMD5 Gene

  1. Molecular cloning and expression of a 26 S protease subunit enriched in dileucine repeats. (PMID: 7559544) Deveraux Q … Rechsteiner M (The Journal of biological chemistry 1995) 2 3 4 54
  2. Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones. (PMID: 19490896) Kaneko T … Murata S (Cell 2009) 3 4 54
  3. Chaperone-mediated pathway of proteasome regulatory particle assembly. (PMID: 19412159) Roelofs J … Finley D (Nature 2009) 3 4 54
  4. Hsm3/S5b participates in the assembly pathway of the 19S regulatory particle of the proteasome. (PMID: 19217412) Le Tallec B … Peyroche A (Molecular cell 2009) 3 4 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collectio