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The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a non-ATPase subunit of the 19S regulator base that functions as a chaperone protein during 26S proteasome assembly. [provided by RefSeq, Jul 2012]
PSMD5 (Proteasome 26S Subunit, Non-ATPase 5) is a Protein Coding gene. Diseases associated with PSMD5 include Myasthenic Syndrome, Congenital, 21, Presynaptic and Ciliary Dyskinesia, Primary, 10. Among its related pathways are Downstream signaling events of B Cell Receptor (BCR) and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include binding and protein binding involved in protein folding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 16189514 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000502 | proteasome complex | TAS | 8811196 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0008540 | colocalizes_with proteasome regulatory particle, base subcomplex | IDA | 19412159 |
GO:0022624 | proteasome accessory complex | ISS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | CDK-mediated phosphorylation and removal of Cdc6 |
.93
.93
|
.80
.78
.70
.47
.31
|
2 | RET signaling |
.92
|
.92
|
3 | Chks in Checkpoint Regulation |
Chks in Checkpoint Regulation
.59
G2-M Phase Transition
.59
Estrogen-mediated S-Phase Entry
.55
|
SREBP Proteolysis
.43
DNA Repair Mechanisms
.32
Parkinson's Disease Pathway
.31
|
4 | HIV Life Cycle |
.64
|
.45
|
5 | Class I MHC mediated antigen processing and presentation |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000165 | MAPK cascade | TAS | -- |
GO:0000209 | protein polyubiquitination | TAS | -- |
GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
GO:0006521 | regulation of cellular amino acid metabolic process | TAS | -- |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||||||||||||
SP6: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PSMD5 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
PSMD5 30 |
|
||||
Cow (Bos Taurus) |
Mammalia | PSMD5 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Psmd5 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Psmd5 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | PSMD5 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | PSMD5 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | PSMD5 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | PSMD5 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | psmd5 30 |
|
||
Str.5115 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.18176 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | psmd5 30 31 |
|
OneToOne | |
Dr.15234 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.13887 30 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001490 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG12096 30 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.11066 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 09 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs17282618 | - |
p.Leu72His |
|||
rs2297575 | - |
p.Glu21Gly |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1051370 | CNV | gain | 25217958 |
Disorder | Aliases | PubMed IDs |
---|---|---|
myasthenic syndrome, congenital, 21, presynaptic |
|
|
ciliary dyskinesia, primary, 10 |
|
|
osteogenesis imperfecta, type xvi |
|
|
ciliary dyskinesia, primary, 9 |
|
|
retinitis pigmentosa |
|
|