PSMD5 Gene (Protein Coding)

Proteasome 26S Subunit, Non-ATPase 5

GC09M120815
GIFtS:
39
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 n... See more...

Aliases for PSMD5 Gene

Aliases for PSMD5 Gene

  • Proteasome 26S Subunit, Non-ATPase 5 2 3 5
  • Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 5 2 3
  • 26S Proteasome Non-ATPase Regulatory Subunit 5 3 4
  • 26S Protease Subunit S5 Basic 3 4
  • 26S Proteasome Subunit S5B 3 4
  • KIAA0072 2 4
  • S5B 2 3
  • PSMD5 5

External Ids for PSMD5 Gene

Previous GeneCards Identifiers for PSMD5 Gene

  • GC09M114682
  • GC09M115224
  • GC09M117031
  • GC09M118954
  • GC09M120657
  • GC09M122617
  • GC09M123577
  • GC09M093196

Summaries for PSMD5 Gene

Entrez Gene Summary for PSMD5 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a non-ATPase subunit of the 19S regulator base that functions as a chaperone protein during 26S proteasome assembly. [provided by RefSeq, Jul 2012]

GeneCards Summary for PSMD5 Gene

PSMD5 (Proteasome 26S Subunit, Non-ATPase 5) is a Protein Coding gene. Diseases associated with PSMD5 include Myasthenic Syndrome, Congenital, 21, Presynaptic and Ciliary Dyskinesia, Primary, 10. Among its related pathways are Downstream signaling events of B Cell Receptor (BCR) and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include binding and protein binding involved in protein folding.

UniProtKB/Swiss-Prot Summary for PSMD5 Gene

  • Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5.

Gene Wiki entry for PSMD5 Gene

Additional gene information for PSMD5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSMD5 Gene

Genomics for PSMD5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for PSMD5 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH09J120841 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 -0.1 -50 2.8 CHD2 CEBPA BRCA1 ETS1 ZFP64 ZNF217 POLR2A ELF1 HOMEZ THAP11 HSALNG0074138 PSMD5 piR-41780 CUTALP lnc-B3GNT10-21 PHF19
GH09J120844 Promoter 0.4 Ensembl 250.7 -2.0 -1950 0.2 ZNF512 PSMD5 piR-41780 piR-61909 CUTALP lnc-B3GNT10-21 PHF19
GH09J121070 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 34.7 -230.7 -230715 5.5 TBP ZBTB10 MXD4 ZNF217 MNT IKZF1 SMAD5 ETS1 POLR2A CTCF CNTRL C5 HSALNG0074155 PSMD5 CUTALP FBXW2 ENSG00000270917 TRAF1 DAB2IP HSALNG0074154
GH09J120791 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 38.6 +50.0 50036 3.8 TBP SP1 MXD4 SIX5 MNT DEK IKZF1 ETS1 IRF2 HES1 FBXW2 B3GALT9 lnc-CNTRL-2 lnc-PSMD5-3 piR-36171 PSMD5 CUTALP CNTRL
GH09J120709 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 28.1 +130.1 130061 6.9 ZSCAN16 TBP ZBTB10 SP1 MNT IKZF1 SMAD5 IRF2 MBD2 BHLHE40 MEGF9 CUTALP CNTRL PSMD5 FBXW2 piR-41306-271 CDK5RAP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSMD5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PSMD5

Top Transcription factor binding sites by QIAGEN in the PSMD5 gene promoter:
  • AP-1
  • CHOP-10
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1a
  • Nkx6-1
  • p53
  • Pax-5
  • STAT3

Genomic Locations for PSMD5 Gene

Latest Assembly
chr9:120,815,496-120,842,951
(GRCh38/hg38)
Size:
27,456 bases
Orientation:
Minus strand

Previous Assembly
chr9:123,578,331-123,605,200
(GRCh37/hg19 by Entrez Gene)
Size:
26,870 bases
Orientation:
Minus strand

chr9:123,577,774-123,605,262
(GRCh37/hg19 by Ensembl)
Size:
27,489 bases
Orientation:
Minus strand

Genomic View for PSMD5 Gene

Genes around PSMD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMD5 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PSMD5 Gene

Proteins for PSMD5 Gene

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  • Protein details for PSMD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16401-PSMD5_HUMAN
    Recommended name:
    26S proteasome non-ATPase regulatory subunit 5
    Protein Accession:
    Q16401
    Secondary Accessions:
    • B4DZM8
    • Q15045
    • Q4VXG8

    Protein attributes for PSMD5 Gene

    Size:
    504 amino acids
    Molecular mass:
    56196 Da
    Quaternary structure:
    • Interacts with PSMC1, PSMC2, PSMD1 and PSMD6. Part of transient complex containing PSMD5, PSMC2, PSMC1 and PSMD2 formed during the assembly of the 26S proteasome.

    Alternative splice isoforms for PSMD5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMD5 Gene

Protein Expression for PSMD5 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for PSMD5 Gene

  • Ubiquitination at Lys143, Lys147, and Lys467
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMD5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PSMD5 Gene

Domains & Families for PSMD5 Gene

Gene Families for PSMD5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PSMD5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PSMD5 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ52877, highly similar to 26S proteasome non-ATPase regulatory subunit 5 (B4DZM8_HUMAN)
  • 26S proteasome subunit S5B (PSMD5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16401

UniProtKB/Swiss-Prot:

PSMD5_HUMAN :
  • Rich in dileucine repeats, which have been implicated in trafficking of a variety of transmembrane proteins.
  • Belongs to the proteasome subunit S5B/HSM3 family.
Domain:
  • Rich in dileucine repeats, which have been implicated in trafficking of a variety of transmembrane proteins.
Family:
  • Belongs to the proteasome subunit S5B/HSM3 family.
genes like me logo Genes that share domains with PSMD5: view

Function for PSMD5 Gene

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  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Molecular function for PSMD5 Gene

UniProtKB/Swiss-Prot Function:
Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5.

Phenotypes From GWAS Catalog for PSMD5 Gene

Gene Ontology (GO) - Molecular Function for PSMD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with PSMD5: view
genes like me logo Genes that share phenotypes with PSMD5: view

Animal Models for PSMD5 Gene

MGI Knock Outs for PSMD5:
  • Psmd5 Psmd5<tm1b(EUCOMM)Wtsi>

Animal Models for research

miRNA for PSMD5 Gene

miRTarBase miRNAs that target PSMD5

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMD5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PSMD5 Gene

Localization for PSMD5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMD5 gene
Compartment Confidence
cytosol 5
cytoskeleton 4
nucleus 4
plasma membrane 2
extracellular 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
lysosome 2
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PSMD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex TAS 8811196
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0008540 colocalizes_with proteasome regulatory particle, base subcomplex IDA 19412159
GO:0022624 proteasome accessory complex ISS --
genes like me logo Genes that share ontologies with PSMD5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PSMD5 Gene

Pathways & Interactions for PSMD5 Gene

PathCards logo

SuperPathways for PSMD5 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
Activation of APC/C and APC/C-Cdc20 mediated degradation of mitotic proteins
.95
Cdc20-Phospho-APC/C mediated degradation of Cyclin A
.95
Autodegradation of the E3 ubiquitin ligase COP1
.95
Stabilization of p53
.95
Regulation of activated PAK-2p34 by proteasome mediated degradation
.94
Regulation of Apoptosis
.94
CDK-mediated phosphorylation and removal of Cdc6
.94
Ubiquitin-dependent degradation of Cyclin D
.94
Ubiquitin-dependent degradation of Cyclin D1
.94
Orc1 removal from chromatin
.94
Regulation of DNA replication
.94
Switching of origins to a post-replicative state
.94
Cyclin A-Cdk2-associated events at S phase entry
.93
Cyclin E associated events during G1/S transition
.93
APC/C-Cdc20 mediated degradation of Securin
.93
APC/C-Cdh1 mediated degradation of Cdc20 and other APC/C-Cdh1 targeted proteins in late mitosis/early G1
.93
APC/C-mediated degradation of cell cycle proteins
.93
Regulation of APC/C activators between G1/S and early anaphase
.93
Regulation of mitotic cell cycle
.93
DNA Replication
.93
Synthesis of DNA
.93
Vpu mediated degradation of CD4
.93
Autodegradation of Cdh1 by Cdh1-APC/C
.91
SCF-beta-TrCP mediated degradation of Emi1
.91
p53-Independent DNA Damage Response
.91
p53-Independent G1/S DNA damage checkpoint
.91
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
.91
ABC transporter disorders
.91
Disorders of transmembrane transporters
.91
Defective CFTR causes cystic fibrosis
.90
Assembly of the pre-replicative complex
.90
Hedgehog ligand biogenesis
.90
Hh mutants abrogate ligand secretion
.90
APC/C-Cdc20 mediated degradation of mitotic proteins
.89
APC-Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
.89
Vif-mediated degradation of APOBEC3G
.89
Degradation of GLI1 by the proteasome
.89
Degradation of GLI2 by the proteasome
.89
GLI3 is processed to GLI3R by the proteasome
.89
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
.88
Degradation of AXIN
.88
Cellular response to hypoxia
.87
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
.87
Regulation of Hypoxia-inducible Factor (HIF) by oxygen
.87
CDT1 association with the CDC6-ORC-origin complex
.87
Hh mutants that dont undergo autocatalytic processing are degraded by ERAD
.87
AUF1 (hnRNP D0) binds and destabilizes mRNA
.86
p53-Dependent G1 DNA Damage Response
.86
p53-Dependent G1/S DNA damage checkpoint
.86
SCF(Skp2)-mediated degradation of p27/p21
.86
Removal of licensing factors from origins
.86
NIK-->noncanonical NF-kB signaling
.85
Dectin-1 mediated noncanonical NF-kB signaling
.84
G1/S DNA Damage Checkpoints
.84
Degradation of DVL
.83
Cross-presentation of soluble exogenous antigens (endosomes)
.82
The role of GTSE1 in G2/M progression after G2 checkpoint
.81
Regulation of ornithine decarboxylase (ODC)
.81
DNA Replication Pre-Initiation
.80
M/G1 Transition
.80
S Phase
.78
Activation of NF-kappaB in B cells
.77
Asymmetric localization of PCP proteins
.74
FCERI mediated NF-kB activation
.72
Regulation of RAS by GAPs
.70
PCP/CE pathway
.70
Beta-catenin independent WNT signaling
.64
Degradation of beta-catenin by the destruction complex
.64
Regulation of mRNA stability by proteins that bind AU-rich elements
.63
Metabolism of polyamines
.60
ABC-family proteins mediated transport
.58
TNFR2 non-canonical NF-kB pathway
.58
MAPK6/MAPK4 signaling
.57
Proteasome Degradation
.56
UCH proteinases
.47
Canonical Wnt Pathway
.31
Apoptosis
.31
Programmed Cell Death
.31
2 RET signaling
Frs2-mediated activation
.95
GRB2 events in EGFR signaling
.95
MAPK1/MAPK3 signaling
.95
Prolonged ERK activation events
.95
RAF/MAP kinase cascade
.95
SHC1 events in EGFR signaling
.95
Signaling by Leptin
.95
SOS-mediated signalling
.95
VEGFR2 mediated cell proliferation
.95
ARMS-mediated activation
.95
Signalling to ERKs
.95
Signalling to p38 via RIT and RIN
.95
Signalling to RAS
.95
Interleukin receptor SHC signaling
.95
Interleukin-3, 5 and GM-CSF signaling
.94
Interleukin-2 signaling
.94
Downstream signal transduction
.94
Signaling by PDGF
.94
DAP12 signaling
.92
RET signaling
.92
Insulin receptor signalling cascade
.92
Signaling by Insulin receptor
.92
IRS-mediated signalling
.91
Signaling by EGFR
.90
FCERI mediated MAPK activation
.90
IGF1R signaling cascade
.90
IRS-related events triggered by IGF1R
.90
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
.90
DAP12 interactions
.89
NCAM signaling for neurite out-growth
.89
NGF signalling via TRKA from the plasma membrane
.87
MAPK family signaling cascades
.87
Signaling by SCF-KIT
.85
Signalling by NGF
.81
Fc epsilon receptor (FCERI) signaling
.79
VEGFA-VEGFR2 Pathway
.78
Signaling by VEGF
.76
Gastrin-CREB signalling pathway via PKC and MAPK
.55
3 Chks in Checkpoint Regulation
Chks in Checkpoint Regulation
.59
G2-M Phase Transition
.59
Estrogen-mediated S-Phase Entry
.55
SREBP Proteolysis
.43
DNA Repair Mechanisms
.32
Parkinson's Disease Pathway
.31
4 HIV Life Cycle
HIV Infection
.64
Infectious disease
.61
Host Interactions of HIV factors
.57
Disease
.45
Diseases of signal transduction
.43
5 Class I MHC mediated antigen processing and presentation
Antigen processing- Ubiquitination and Proteasome degradation
.83
Class I MHC mediated antigen processing and presentation
.83
Adaptive Immune System
.45
genes like me logo Genes that share pathways with PSMD5: view

Pathways by source for PSMD5 Gene

1 Sino Biological pathway for PSMD5 Gene
3 GeneGo (Thomson Reuters) pathways for PSMD5 Gene
  • Immune response Antigen presentation by MHC class I
  • Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
  • Transcription Ligand-Dependent Transcription of Retinoid-Target genes
19 Qiagen pathways for PSMD5 Gene
  • CDK5 Pathway
  • Chks in Checkpoint Regulation
  • DNA Repair Mechanisms
  • Estrogen-mediated S-Phase Entry
  • G2-M Phase Transition

Gene Ontology (GO) - Biological Process for PSMD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006521 regulation of cellular amino acid metabolic process TAS --
genes like me logo Genes that share ontologies with PSMD5: view

No data available for SIGNOR curated interactions for PSMD5 Gene

Drugs & Compounds for PSMD5 Gene

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(2) Drugs for PSMD5 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 926
carfilzomib Approved, Investigational Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
genes like me logo Genes that share compounds with PSMD5: view

Transcripts for PSMD5 Gene

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mRNA/cDNA for PSMD5 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMD5

Alternative Splicing Database (ASD) splice patterns (SP) for PSMD5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c
SP1: - - - -
SP2:
SP3: -
SP4: - -
SP5:
SP6:

Relevant External Links for PSMD5 Gene

GeneLoc Exon Structure for
PSMD5

Expression for PSMD5 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PSMD5 Gene

mRNA expression in normal human tissues for PSMD5 Gene
mRNA expression by BioGPS for PSMD5 GenemRNA expression by GTEx for PSMD5 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMD5 Gene



Protein tissue co-expression partners for PSMD5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PSMD5

SOURCE GeneReport for Unigene cluster for PSMD5 Gene:

Hs.193725

Evidence on tissue expression from TISSUES for PSMD5 Gene

  • Skin(4.6)
  • Blood(4.5)
  • Liver(4.5)
  • Bone marrow(4.4)
  • Nervous system(3.8)
  • Kidney(2.6)
  • Intestine(2.6)
  • Heart(2.6)
  • Spleen(2.4)
  • Lung(2.3)
  • Muscle(2.3)
  • Pancreas(2.2)
  • Lymph node(2.2)
  • Eye(2.1)
genes like me logo Genes that share expression patterns with PSMD5: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMD5 Gene

Orthologs for PSMD5 Gene

This gene was present in the common ancestor of animals.

Orthologs for PSMD5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia PSMD5 30 31
  • 99.54 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia -- 31
  • 92 (a)
 OneToMany
-- 31
  • 92 (a)
 OneToMany
PSMD5 30
  • 90.11 (n)
Cow
(Bos Taurus)
 Mammalia PSMD5 30 31
  • 90.92 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Psmd5 30
  • 87.7 (n)
Mouse
(Mus musculus)
 Mammalia Psmd5 30 17 31
  • 87.63 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia PSMD5 31
  • 87 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia PSMD5 31
  • 86 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves PSMD5 30 31
  • 73.88 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia PSMD5 31
  • 71 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia psmd5 30
  • 66.33 (n)
Str.5115 30
African clawed frog
(Xenopus laevis)
 Amphibia Xl.18176 30
Zebrafish
(Danio rerio)
 Actinopterygii psmd5 30 31
  • 58.99 (n)
 OneToOne
Dr.15234 30
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.13887 30
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP001490 30
  • 40.64 (n)
Fruit Fly
(Drosophila melanogaster)
 Insecta CG12096 30 31
  • 40.6 (n)
 OneToOne
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.11066 31
  • 32 (a)
 OneToOne
Species where no ortholog for PSMD5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PSMD5 Gene

ENSEMBL:
Gene Tree for PSMD5 (if available)
TreeFam:
Gene Tree for PSMD5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PSMD5: view image

Paralogs for PSMD5 Gene

No data available for Paralogs for PSMD5 Gene

Variants for PSMD5 Gene

Products:

  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PSMD5 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs17282618 - p.Leu72His
rs2297575 - p.Glu21Gly

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PSMD5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PSMD5 Gene

Variant ID Type Subtype PubMed ID
nsv1051370 CNV gain 25217958

Variation tolerance for PSMD5 Gene

Residual Variation Intolerance Score: 52.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.98; 68.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PSMD5 Gene

Human Gene Mutation Database (HGMD)
PSMD5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMD5

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMD5 Gene

Disorders for PSMD5 Gene

MalaCards: The human disease database

(5) MalaCards diseases for PSMD5 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards
Search PSMD5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PSMD5

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PSMD5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSMD5 Gene

Publications for PSMD5 Gene

  1. Molecular cloning and expression of a 26 S protease subunit enriched in dileucine repeats. (PMID: 7559544) Deveraux Q … Rechsteiner M (The Journal of biological chemistry 1995) 2 3 4
  2. Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones. (PMID: 19490896) Kaneko T … Murata S (Cell 2009) 3 4
  3. Hsm3/S5b participates in the assembly pathway of the 19S regulatory particle of the proteasome. (PMID: 19217412) Le Tallec B … Peyroche A (Molecular cell 2009) 3 4
  4. Chaperone-mediated pathway of proteasome regulatory particle assembly. (PMID: 19412159) Roelofs J … Finley D (Nature 2009) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

ExternalLinks

View latest publications for PSMD5 gene in Mastermind

Products for PSMD5 Gene