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Aliases for PSMD4 Gene

Aliases for PSMD4 Gene

  • Proteasome 26S Subunit, Non-ATPase 4 2 3 5
  • Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 4 2 3
  • 26S Proteasome Regulatory Subunit S5A 3 4
  • Multiubiquitin Chain-Binding Protein 3 4
  • Antisecretory Factor 1 3 4
  • MCB1 3 4
  • ASF 3 4
  • AF 3 4
  • 26S Proteasome Non-ATPase Regulatory Subunit 4 3
  • 26S Proteasome Regulatory Subunit RPN10 4
  • S5a/Antisecretory Factor Protein 3
  • Angiocidin 3
  • PUB-R5 3
  • Rpn10 3
  • AF-1 3
  • S5A 3

External Ids for PSMD4 Gene

Previous GeneCards Identifiers for PSMD4 Gene

  • GC01P149069
  • GC01P146974
  • GC01P148002
  • GC01P148443
  • GC01P148040
  • GC01P149493
  • GC01P122605

Summaries for PSMD4 Gene

Entrez Gene Summary for PSMD4 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21. [provided by RefSeq, Jul 2008]

CIViC summary for PSMD4 Gene

GeneCards Summary for PSMD4 Gene

PSMD4 (Proteasome 26S Subunit, Non-ATPase 4) is a Protein Coding gene. Diseases associated with PSMD4 include Angelman Syndrome. Among its related pathways are Cell Cycle, Mitotic and RET signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding.

UniProtKB/Swiss-Prot for PSMD4 Gene

  • Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains.

Gene Wiki entry for PSMD4 Gene

Additional gene information for PSMD4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMD4 Gene

Genomics for PSMD4 Gene

GeneHancer (GH) Regulatory Elements for PSMD4 Gene

Promoters and enhancers for PSMD4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J151254 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.4 418 2.1 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 PSMD4 ARNT HORMAD1 ZNF687
GH01J151193 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 15.4 -57.1 -57054 7.7 PKNOX1 CLOCK FOXA2 SMAD1 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 ZBTB7B PIP5K1A ZNF687 ARNT SETDB1 PRPF3 GOLPH3L PI4KB UBE2D3P3 RPS10P6 MRPL9
GH01J151308 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.7 +57.2 57236 6.1 PKNOX1 SMAD1 FOXA2 ARNT ARID4B NEUROD1 SIN3A YY1 ZNF766 E2F8 PIP5K1A PRPF3 GABPB2 PI4KB MRPL9 ZNF687 RFX5 LOC100507670 SETDB1 POGZ
GH01J151054 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 5.6 -195.7 -195696 9.9 CLOCK YBX1 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 MLLT11 CDC42SE1 SETDB1 PRPF3 ARNT PIP5K1A PI4KB ZNF687 GABPB2 UBE2D3P3
GH01J151280 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 5.4 +27.9 27887 3.8 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 ZNF687 GC01P151282 LOC100507670 PIP5K1A SETDB1 ARNT GOLPH3L PRPF3 MRPL9 GABPB2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PSMD4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PSMD4 gene promoter:
  • STAT3
  • Nkx2-2
  • LCR-F1
  • CUTL1
  • POU2F1a
  • POU2F1
  • Max1
  • c-Myc
  • FOXD3

Genomic Locations for PSMD4 Gene

Genomic Locations for PSMD4 Gene
chr1:151,254,700-151,267,479
(GRCh38/hg38)
Size:
12,780 bases
Orientation:
Plus strand
chr1:151,227,179-151,239,955
(GRCh37/hg19)
Size:
12,777 bases
Orientation:
Plus strand

Genomic View for PSMD4 Gene

Genes around PSMD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMD4 Gene

Proteins for PSMD4 Gene

  • Protein details for PSMD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55036-PSMD4_HUMAN
    Recommended name:
    26S proteasome non-ATPase regulatory subunit 4
    Protein Accession:
    P55036
    Secondary Accessions:
    • D3DV16
    • Q5VWC5
    • Q9NS92

    Protein attributes for PSMD4 Gene

    Size:
    377 amino acids
    Molecular mass:
    40737 Da
    Quaternary structure:
    • Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases and few additional components including PSMD4 (PubMed:27428775, PubMed:27342858). Interacts with NUB1 (PubMed:11585840). Interacts with SQSTM1 (PubMed:15340068). Interacts with UBQLN4 (PubMed:15280365). Interacts with UBE3A (PubMed:22645313). Interacts with UBQLN1 (via ubiquitin-like domain) (PubMed:15147878).

    Three dimensional structures from OCA and Proteopedia for PSMD4 Gene

    Alternative splice isoforms for PSMD4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMD4 Gene

Post-translational modifications for PSMD4 Gene

  • Ubiquitination at Lys365, Lys262, Lys126, posLast=8383, and posLast=4040
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PSMD4 Gene

Domains & Families for PSMD4 Gene

Gene Families for PSMD4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for PSMD4 Gene

Graphical View of Domain Structure for InterPro Entry

P55036

UniProtKB/Swiss-Prot:

PSMD4_HUMAN :
  • The 2 UIM motifs are involved in the binding to a multi-ubiquitin chain in a cooperative way.
  • Belongs to the proteasome subunit S5A family.
Domain:
  • The 2 UIM motifs are involved in the binding to a multi-ubiquitin chain in a cooperative way.
Family:
  • Belongs to the proteasome subunit S5A family.
genes like me logo Genes that share domains with PSMD4: view

Function for PSMD4 Gene

Molecular function for PSMD4 Gene

UniProtKB/Swiss-Prot Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains.
GENATLAS Biochemistry:
multicatalytic proteinase complex (prosome,macropain 26S) regulator of proteasome,non ATPase subunit,50kDa,more acidic subunit 5A,specifically binding ubiquitin-lysozyme conjugates antisecretory factor 1,inhibiting intestinal fluid secretion

Phenotypes From GWAS Catalog for PSMD4 Gene

Gene Ontology (GO) - Molecular Function for PSMD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 8570649
GO:0008134 transcription factor binding IEA --
GO:0031593 polyubiquitin modification-dependent protein binding IBA --
GO:0042802 identical protein binding IPI 16990800
genes like me logo Genes that share ontologies with PSMD4: view
genes like me logo Genes that share phenotypes with PSMD4: view

Animal Models for PSMD4 Gene

MGI Knock Outs for PSMD4:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMD4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PSMD4 Gene

Localization for PSMD4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMD4 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PSMD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA,IEA 17323924
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm IDA,TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS,IDA --
genes like me logo Genes that share ontologies with PSMD4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PSMD4 Gene

Pathways & Interactions for PSMD4 Gene

SuperPathways for PSMD4 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 Chks in Checkpoint Regulation
4 HIV Life Cycle
.45
5 Class I MHC mediated antigen processing and presentation
genes like me logo Genes that share pathways with PSMD4: view

Gene Ontology (GO) - Biological Process for PSMD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
genes like me logo Genes that share ontologies with PSMD4: view

No data available for SIGNOR curated interactions for PSMD4 Gene

Drugs & Compounds for PSMD4 Gene

(17) Drugs for PSMD4 Gene - From: ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 826
carfilzomib Approved, Investigational Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
AM 114 Pharma 20S proteasome inhibitor 0
Bortezomib (PS-341) Pharma Proteasome Inhibitor 0
Carfilzomib (PR-171) Pharma Proteasome inhibitor,epoxomicin analog 0

(1) Additional Compounds for PSMD4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(14) ApexBio Compounds for PSMD4 Gene

Compound Action Cas Number
AM 114 20S proteasome inhibitor 856849-35-9
Bortezomib (PS-341) Proteasome Inhibitor 179324-69-7
Carfilzomib (PR-171) Proteasome inhibitor,epoxomicin analog 868540-17-4
Celastrol Antioxidant, anti-inflammatory and immunosuppressive agent 34157-83-0
CEP-18770 Proteasome inhibitor 847499-27-8
Dihydroeponemycin Proteasome inhibitor,antitumor reagent,eponemycin ddrivative 126463-64-7
Epoxomicin Proteasome inhibitor 134381-21-8
MG-132 Proteasome inhibitor, Cell permeable, reversible 133407-82-6
MLN2238 β5 site of the 20S proteasome inhibitor 1072833-77-2
MLN9708 Proteasome inhibitor 1201902-80-8
ONX-0914 (PR-957) Immunoproteasome inhibitor,potent and selective 960374-59-8
Oprozomib (ONX-0912) Proteasome inhibitor 935888-69-0
PI-1840 Chymotrypsin-like (CT-L) inhibitor 1401223-22-0
PSI Proteasome inhibitor 158442-41-2
genes like me logo Genes that share compounds with PSMD4: view

Drug Products

Transcripts for PSMD4 Gene

mRNA/cDNA for PSMD4 Gene

Unigene Clusters for PSMD4 Gene

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMD4

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMD4 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c
SP1: - - -
SP2: - -
SP3:
SP4: -
SP5: -
SP6: -
SP7:

Relevant External Links for PSMD4 Gene

GeneLoc Exon Structure for
PSMD4
ECgene alternative splicing isoforms for
PSMD4

Expression for PSMD4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSMD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PSMD4 Gene

This gene is overexpressed in Amniocyte (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMD4 Gene



Protein tissue co-expression partners for PSMD4 Gene

NURSA nuclear receptor signaling pathways regulating expression of PSMD4 Gene:

PSMD4

SOURCE GeneReport for Unigene cluster for PSMD4 Gene:

Hs.505059

Evidence on tissue expression from TISSUES for PSMD4 Gene

  • Lung(4.8)
  • Nervous system(4.7)
  • Liver(4.4)
  • Intestine(3)
  • Muscle(2.6)
  • Eye(2.1)
genes like me logo Genes that share expression patterns with PSMD4: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMD4 Gene

Orthologs for PSMD4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMD4 34 33
  • 99.65 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PSMD4 34 33
  • 92.93 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PSMD4 34 33
  • 92.75 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psmd4 33
  • 91.21 (n)
mouse
(Mus musculus)
Mammalia Psmd4 16 34 33
  • 90.45 (n)
oppossum
(Monodelphis domestica)
Mammalia PSMD4 34
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves PSMD4 34 34
  • 95 (a)
OneToMany
LOC100857577 33
  • 80.77 (n)
lizard
(Anolis carolinensis)
Reptilia PSMD4 34
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6951 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.3773 33
zebrafish
(Danio rerio)
Actinopterygii psmd4b 34
  • 82 (a)
OneToMany
psmd4a 34 33
  • 77.93 (n)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Pros54 34 35 33
  • 63.64 (n)