The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 n... See more...

Aliases for PSMD2 Gene

Aliases for PSMD2 Gene

  • Proteasome 26S Subunit Ubiquitin Receptor, Non-ATPase 2 2 3
  • Proteasome 26S Subunit, Non-ATPase 2 2 3 5
  • TRAP2 2 3 4
  • Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 2 2 3
  • Tumor Necrosis Factor Type 1 Receptor-Associated Protein 2 3 4
  • 26S Proteasome Non-ATPase Regulatory Subunit 2 3 4
  • Protein 55.11 3 4
  • P97 2 3
  • S2 2 3
  • 26S Proteasome Regulatory Subunit RPN1 4
  • 26S Proteasome Regulatory Subunit S2 4
  • 26S Proteasome Subunit P97 4
  • TNFR-Associated Protein 2 3
  • 55.11 Protein 3
  • MGC14274 2
  • PSMD2 5
  • RPN1 3
  • Rpn1 2

External Ids for PSMD2 Gene

Previous GeneCards Identifiers for PSMD2 Gene

  • GC03P180586
  • GC03P185010
  • GC03P185418
  • GC03P185337
  • GC03P185500
  • GC03P184016
  • GC03P181423

Summaries for PSMD2 Gene

Entrez Gene Summary for PSMD2 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

GeneCards Summary for PSMD2 Gene

PSMD2 (Proteasome 26S Subunit Ubiquitin Receptor, Non-ATPase 2) is a Protein Coding gene. Diseases associated with PSMD2 include Cystic Fibrosis and Angelman Syndrome. Among its related pathways are RET signaling and Presenilin-Mediated Signaling. Gene Ontology (GO) annotations related to this gene include binding and enzyme regulator activity. An important paralog of this gene is PSMD1.

UniProtKB/Swiss-Prot Summary for PSMD2 Gene

  • Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
  • Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.

Gene Wiki entry for PSMD2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSMD2 Gene

Genomics for PSMD2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PSMD2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J184298 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 261.9 +0.5 471 2.9 ZNF207 NCOR1 MYC ZNF600 SIX5 JUND POLR2A BRCA1 YY1 MXD4 PSMD2 RF00017-3776 ABCF3 VWA5B2 HSALNG0031225 EIF4G1
GH03J184184 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.4 -113.1 -113101 3.6 SP1 IKZF1 NCOR1 MYC ZNF600 SIX5 ZNF592 POLR2A ATF3 NFIC ABCF3 HSALNG0031211-001 HSALNG0031211-002 HSALNG0031212 POLR2H ALG3 EIF2B5 VWA5B2 DVL3 RPS3P3
GH03J184330 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 9.8 +36.2 36206 9 SP1 IKZF1 ZNF600 SIX5 SSRP1 JUND ZNF592 ATF2 POLR2A ZNF10 FAM131A HSALNG0031231 RPS3P3 DVL3 EIF2B5 YEATS2 ABCF3 POLR2H PSMD2 VWA5B2
GH03J184155 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.5 -142.8 -142797 4.8 SP1 MYC IKZF1 ZNF592 POLR2A ZBTB10 NONO ELK1 ZNF639 ZNF341 DVL3 EIF2B5 ABCF3 ALG3 ECE2 CAMK2N2 PSMD2 VWA5B2 MIR1224 EIF4G1
GH03J184318 Promoter/Enhancer 1.1 Ensembl ENCODE 13.2 +21.9 21855 5.3 JUND POLR2A YY1 MAX ZBTB7B ZNF217 CTBP1 RXRA EBF1 RBM22 PSMD2 ABCF3 DVL3 SNORD66 EIF4G1 HSALNG0031227 NONHSAG036851.2 FAM131A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSMD2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PSMD2

Top Transcription factor binding sites by QIAGEN in the PSMD2 gene promoter:
  • NF-kappaB
  • NF-kappaB1
  • p53

Genomic Locations for PSMD2 Gene

Latest Assembly
chr3:184,299,198-184,309,050
(GRCh38/hg38)
Size:
9,853 bases
Orientation:
Plus strand

Previous Assembly
chr3:184,017,029-184,026,838
(GRCh37/hg19 by Entrez Gene)
Size:
9,810 bases
Orientation:
Plus strand

chr3:184,016,497-184,026,842
(GRCh37/hg19 by Ensembl)
Size:
10,346 bases
Orientation:
Plus strand

Genomic View for PSMD2 Gene

Genes around PSMD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMD2 Gene

Proteins for PSMD2 Gene

  • Protein details for PSMD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13200-PSMD2_HUMAN
    Recommended name:
    26S proteasome non-ATPase regulatory subunit 2
    Protein Accession:
    Q13200
    Secondary Accessions:
    • B4DX07
    • B4DXY1
    • E7EW34
    • E9PCS3
    • Q12932
    • Q15321
    • Q53XQ4
    • Q96I12

    Protein attributes for PSMD2 Gene

    Size:
    908 amino acids
    Molecular mass:
    100200 Da
    Quaternary structure:
    • Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases and few additional components including PSMD2 (PubMed:27428775, PubMed:27342858). Interacts with RPGRIP1L (By similarity). Interacts with CRY1 in a KDM8-dependent manner (By similarity).
    SequenceCaution:
    • Sequence=AAA87705.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PSMD2 Gene

    Alternative splice isoforms for PSMD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMD2 Gene

Post-translational modifications for PSMD2 Gene

  • Ubiquitination at Lys178, Lys31, Lys66, Lys105, Lys286, Lys292, Lys141, Lys350, Lys397, Lys441, Lys754, Lys773, Lys858, Lys860, and Lys902
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PSMD2 Gene

Domains & Families for PSMD2 Gene

Gene Families for PSMD2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for PSMD2 Gene

Suggested Antigen Peptide Sequences for PSMD2 Gene

GenScript: Design optimal peptide antigens:
  • Tumor necrosis factor type 1 receptor-associated protein 2 (PSMD2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13200

UniProtKB/Swiss-Prot:

PSMD2_HUMAN :
  • Belongs to the proteasome subunit S2 family.
Family:
  • Belongs to the proteasome subunit S2 family.
genes like me logo Genes that share domains with PSMD2: view

Function for PSMD2 Gene

Molecular function for PSMD2 Gene

UniProtKB/Swiss-Prot Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
UniProtKB/Swiss-Prot Function:
Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.

Phenotypes From GWAS Catalog for PSMD2 Gene

Gene Ontology (GO) - Molecular Function for PSMD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 contributes_to endopeptidase activity IBA 21873635
GO:0005515 protein binding IPI 11278995
GO:0030234 enzyme regulator activity IEA --
genes like me logo Genes that share ontologies with PSMD2: view
genes like me logo Genes that share phenotypes with PSMD2: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMD2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMD2 Gene

Localization for PSMD2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMD2 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 4
plasma membrane 3
endoplasmic reticulum 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PSMD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IEA,IDA 17323924
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PSMD2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for PSMD2 Gene

Pathways & Interactions for PSMD2 Gene

PathCards logo

SuperPathways for PSMD2 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 Chks in Checkpoint Regulation
.59
.59
.55
.43
.32
.31
4 HIV Life Cycle
.45
5 Pathways of neurodegeneration - multiple diseases
genes like me logo Genes that share pathways with PSMD2: view

Pathways by source for PSMD2 Gene

3 GeneGo (Thomson Reuters) pathways for PSMD2 Gene
  • Immune response Antigen presentation by MHC class I
  • Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
  • Transcription Ligand-Dependent Transcription of Retinoid-Target genes
19 Qiagen pathways for PSMD2 Gene
  • CDK5 Pathway
  • Chks in Checkpoint Regulation
  • DNA Repair Mechanisms
  • Estrogen-mediated S-Phase Entry
  • G2-M Phase Transition

Gene Ontology (GO) - Biological Process for PSMD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006521 regulation of cellular amino acid metabolic process TAS --
genes like me logo Genes that share ontologies with PSMD2: view

No data available for SIGNOR curated interactions for PSMD2 Gene

Drugs & Compounds for PSMD2 Gene

(4) Drugs for PSMD2 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 933
carfilzomib Approved, Investigational Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
Oprozomib Investigational Pharma 0
MLN-9708 Pharma 0
genes like me logo Genes that share compounds with PSMD2: view

Transcripts for PSMD2 Gene

mRNA/cDNA for PSMD2 Gene

3 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
20 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMD2

Alternative Splicing Database (ASD) splice patterns (SP) for PSMD2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^
SP1:
SP2: - - - - -
SP3:
SP4:
SP5:
SP6: - - - - - -
SP7:
SP8:
SP9: - - - - - - - - -
SP10: - - - - -
SP11:
SP12: - - -
SP13: - - - -
SP14: -
SP15: -
SP16:
SP17:

ExUns: 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for PSMD2 Gene

GeneLoc Exon Structure for
PSMD2

Expression for PSMD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PSMD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PSMD2 Gene

This gene is overexpressed in Muscle - Skeletal (x4.5).

Protein differential expression in normal tissues from HIPED for PSMD2 Gene

This gene is overexpressed in Lymph node (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMD2 Gene



Protein tissue co-expression partners for PSMD2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PSMD2

SOURCE GeneReport for Unigene cluster for PSMD2 Gene:

Hs.518464

mRNA Expression by UniProt/SwissProt for PSMD2 Gene:

Q13200-PSMD2_HUMAN
Tissue specificity: Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung and placenta.

Evidence on tissue expression from TISSUES for PSMD2 Gene

  • Lung(4.9)
  • Skin(4.9)
  • Nervous system(4.8)
  • Liver(4.7)
  • Muscle(4.6)
  • Blood(4.5)
  • Kidney(4)
  • Pancreas(3.6)
  • Eye(3.4)
  • Intestine(3.4)
  • Heart(2.3)
  • Spleen(2.1)
  • Lymph node(2.1)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with PSMD2: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMD2 Gene

Orthologs for PSMD2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMD2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PSMD2 29 30
  • 99.67 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PSMD2 30
  • 97 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia PSMD2 29 30
  • 92.95 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PSMD2 29 30
  • 92.66 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Gm5422 30
  • 92 (a)
OneToMany
Psmd2 29 16 30
  • 90.86 (n)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Psmd2 29
  • 90.05 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia PSMD2 30
  • 61 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PSMD2 29 30
  • 81.3 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PSMD2 30
  • 93 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia psmd2 29
  • 78.37 (n)
Str.8194 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.26549 29
Zebrafish
(Danio rerio)
Actinopterygii psmd2 29 30
  • 78.09 (n)
OneToMany
PSMD2 (1 of 2) 30
  • 68 (a)
OneToMany
zgc65921 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1127 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002481 29
  • 65 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Rpn1 29 30 31
  • 63.4 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea rpn-1 29 30
  • 57.91 (n)
OneToOne
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ACR072C 29
  • 53.16 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPN1 29 30 32
  • 51.62 (n)
OneToOne
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E11507g 29
  • 51.29 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons RPN1A 29
  • 56.11 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6563 29
Soybean
(Glycine max)
eudicotyledons Gma.1623 29
Rice
(Oryza sativa)
Liliopsida Os09g0326800 29
  • 57.41 (n)
Os.12327 29
Barley
(Hordeum vulgare)
Liliopsida Hv.1785 29
Wheat
(Triticum aestivum)
Liliopsida Ta.20762 29
Corn
(Zea mays)
Liliopsida Zm.5526 29
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 65 (a)
OneToOne
Bread mold
(Neurospora crassa)
Ascomycetes NCU07721 29
  • 55.46 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mts4 29
  • 53.65 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.4602 29
Species where no ortholog for PSMD2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMD2 Gene

ENSEMBL: