The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 n... See more...

Aliases for PSMD13 Gene

Aliases for PSMD13 Gene

  • Proteasome 26S Subunit, Non-ATPase 13 2 3 5
  • Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 13 2 3
  • 26S Proteasome Non-ATPase Regulatory Subunit 13 3 4
  • 26S Proteasome Regulatory Subunit P40.5 3 4
  • 26S Proteasome Regulatory Subunit RPN9 3 4
  • 26S Proteasome Regulatory Subunit S11 3 4
  • P40.5 2 3
  • Rpn9 2 3
  • 26S Proteasome Subunit P40.5 3
  • HSPC027 3
  • PSMD13 5
  • S11 3

External Ids for PSMD13 Gene

Previous GeneCards Identifiers for PSMD13 Gene

  • GC11P000459
  • GC11P000281
  • GC11M000945
  • GC11P000226
  • GC11P000056

Summaries for PSMD13 Gene

Entrez Gene Summary for PSMD13 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Two transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for PSMD13 Gene

PSMD13 (Proteasome 26S Subunit, Non-ATPase 13) is a Protein Coding gene. Diseases associated with PSMD13 include Histrionic Personality Disorder. Among its related pathways are RET signaling and CDK-mediated phosphorylation and removal of Cdc6.

UniProtKB/Swiss-Prot Summary for PSMD13 Gene

  • Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

Gene Wiki entry for PSMD13 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSMD13 Gene

Genomics for PSMD13 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PSMD13 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSMD13 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PSMD13

Top Transcription factor binding sites by QIAGEN in the PSMD13 gene promoter:
  • aMEF-2
  • Arnt
  • COMP1
  • HTF
  • MEF-2
  • MEF-2A
  • Olf-1
  • Pax-2
  • Pax-2a
  • RREB-1

Genomic Locations for PSMD13 Gene

Latest Assembly
chr11:236,966-252,984
(GRCh38/hg38)
Size:
16,019 bases
Orientation:
Plus strand

Previous Assembly
chr11:236,976-252,984
(GRCh37/hg19 by Entrez Gene)
Size:
16,009 bases
Orientation:
Plus strand

chr11:236,546-252,983
(GRCh37/hg19 by Ensembl)
Size:
16,438 bases
Orientation:
Plus strand

Genomic View for PSMD13 Gene

Genes around PSMD13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMD13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMD13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMD13 Gene

Proteins for PSMD13 Gene

  • Protein details for PSMD13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNM6-PSD13_HUMAN
    Recommended name:
    26S proteasome non-ATPase regulatory subunit 13
    Protein Accession:
    Q9UNM6
    Secondary Accessions:
    • B3KT15
    • O75831
    • Q53XU2
    • Q9UNV3

    Protein attributes for PSMD13 Gene

    Size:
    376 amino acids
    Molecular mass:
    42945 Da
    Quaternary structure:
    • Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD13, a base containing 6 ATPases and few additional components.

    Three dimensional structures from OCA and Proteopedia for PSMD13 Gene

    Alternative splice isoforms for PSMD13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMD13 Gene

Post-translational modifications for PSMD13 Gene

  • Ubiquitination at Lys2, Lys99, Lys115, Lys122, Lys161, Lys174, Lys186, Lys252, Lys313, Lys321, and Lys347
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PSMD13 Gene

Domains & Families for PSMD13 Gene

Gene Families for PSMD13 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PSMD13 Gene

InterPro:
Blocks:
  • Domain in components of the proteasome, COP9-complex and eIF3 (PCI)

Suggested Antigen Peptide Sequences for PSMD13 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ53046, highly similar to 26S proteasome non-ATPase regulatory subunit 13 (B4DJ66_HUMAN)
  • 26S proteasome regulatory subunit p40.5 (PSD13_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UNM6

UniProtKB/Swiss-Prot:

PSD13_HUMAN :
  • Belongs to the proteasome subunit S11 family.
Family:
  • Belongs to the proteasome subunit S11 family.
genes like me logo Genes that share domains with PSMD13: view

Function for PSMD13 Gene

Molecular function for PSMD13 Gene

UniProtKB/Swiss-Prot Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

Phenotypes From GWAS Catalog for PSMD13 Gene

Gene Ontology (GO) - Molecular Function for PSMD13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IBA 21873635
genes like me logo Genes that share ontologies with PSMD13: view
genes like me logo Genes that share phenotypes with PSMD13: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMD13

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMD13 Gene

Localization for PSMD13 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMD13 gene
Compartment Confidence
nucleus 5
extracellular 4
cytosol 4
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PSMD13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex TAS,IDA 17323924
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PSMD13: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PSMD13 Gene

Pathways & Interactions for PSMD13 Gene

PathCards logo

SuperPathways for PSMD13 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 HIV Life Cycle
.45
4 Pathways of neurodegeneration - multiple diseases
5 Class I MHC mediated antigen processing and presentation
genes like me logo Genes that share pathways with PSMD13: view

Pathways by source for PSMD13 Gene

3 GeneGo (Thomson Reuters) pathways for PSMD13 Gene
  • Immune response Antigen presentation by MHC class I
  • Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
  • Transcription Ligand-Dependent Transcription of Retinoid-Target genes
2 Qiagen pathways for PSMD13 Gene
  • RAR-Gamma-RXR-Alpha Degradation
  • Remodeling of Adherens Junctions

Gene Ontology (GO) - Biological Process for PSMD13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006511 ubiquitin-dependent protein catabolic process IBA 21873635
genes like me logo Genes that share ontologies with PSMD13: view

No data available for SIGNOR curated interactions for PSMD13 Gene

Drugs & Compounds for PSMD13 Gene

(2) Drugs for PSMD13 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 933
carfilzomib Approved, Investigational Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
genes like me logo Genes that share compounds with PSMD13: view

Transcripts for PSMD13 Gene

mRNA/cDNA for PSMD13 Gene

2 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMD13

Alternative Splicing Database (ASD) splice patterns (SP) for PSMD13 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c · 14d
SP1: - - -
SP2: - - - -
SP3: - -
SP4: -
SP5: - - - -
SP6:
SP7:
SP8:

Relevant External Links for PSMD13 Gene

GeneLoc Exon Structure for
PSMD13

Expression for PSMD13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PSMD13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PSMD13 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMD13 Gene



Protein tissue co-expression partners for PSMD13 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PSMD13

SOURCE GeneReport for Unigene cluster for PSMD13 Gene:

Hs.134688

Evidence on tissue expression from TISSUES for PSMD13 Gene

  • Nervous system(4.9)
  • Lung(4.7)
  • Liver(4.5)
  • Blood(4.5)
  • Kidney(4.5)
  • Skin(4)
  • Intestine(2.6)
  • Eye(2.6)
  • Adrenal gland(2.4)
  • Muscle(2.4)
  • Pancreas(2.3)
  • Heart(2.2)
genes like me logo Genes that share expression patterns with PSMD13: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMD13 Gene

Orthologs for PSMD13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMD13 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PSMD13 29 30
  • 99.56 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PSMD13 29 30
  • 92.82 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PSMD13 29 30
  • 91.22 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Psmd13 29
  • 90.07 (n)
Mouse
(Mus musculus)
Mammalia Psmd13 29 16 30
  • 89.98 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PSMD13 30
  • 51 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PSMD13 30
  • 50 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PSMD13 29 30
  • 82.89 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 85 (a)
OneToMany
-- 30
  • 84 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia psmd13 29
  • 76.06 (n)
Str.1435 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.3428 29
Zebrafish
(Danio rerio)
Actinopterygii psmd13 29 30
  • 73.67 (n)
OneToOne
zgc56377 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9211 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001651 29
  • 55.14 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Rpn9 29 30 31
  • 52.99 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea rpn-9 29 30
  • 48.92 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPN9 29 30 32 32
  • 44.85 (n)
OneToOne
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B00825g 29
  • 44.83 (n)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ADR191C 29
  • 44.13 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT4G19006 29
  • 51.8 (n)
Rice
(Oryza sativa)
Liliopsida Os01g0511300 29
  • 50.27 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 59 (a)
OneToOne
Bread mold
(Neurospora crassa)
Ascomycetes NCU02374 29
  • 51.54 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpn9 29
  • 45.76 (n)
Species where no ortholog for PSMD13 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PSMD13 Gene

ENSEMBL:
Gene Tree for PSMD13 (if available)
TreeFam:
Gene Tree for PSMD13 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PSMD13: view image
Alliance of Genome Resources:
Additional Orthologs for PSMD13

Paralogs for PSMD13 Gene

(1) SIMAP similar genes for PSMD13 Gene using alignment to 8 proteins:

  • PSD13_HUMAN
  • B4DJ66_HUMAN
  • E9PL38_HUMAN
  • E9PPD2_HUMAN
  • E9PQG3_HUMAN
  • F8W8J6_HUMAN
  • H0YD73_HUMAN
  • J3KNQ3_HUMAN
genes like me logo Genes that share paralogs with PSMD13: view

No data available for Paralogs for PSMD13 Gene

Variants for PSMD13 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PSMD13 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs1045288 -- p.Asn13Ser
rs1794108 -- p.Gly204Glu
rs1794109 -- p.Leu205Phe
rs28927679 -- p.Ser150Leu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PSMD13 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PSMD13 Gene

Variant ID Type Subtype PubMed ID
dgv1010n100 CNV gain 25217958
dgv1011n100 CNV gain 25217958
dgv1012n100 CNV gain 25217958
dgv1505n54 CNV gain 21841781
esv32593 CNV loss 17666407
esv3625060 CNV gain 21293372
esv3625064 CNV gain 21293372
nsv1052484 CNV gain 25217958
nsv1069987 CNV deletion 25765185
nsv467631 CNV gain 19166990
nsv469921 CNV gain 18288195
nsv516439 CNV loss 19592680
nsv522596 CNV gain 19592680
nsv527533 CNV gain 19592680
nsv552762 CNV gain 21841781
nsv552765 CNV gain 21841781
nsv552766 CNV loss 21841781
nsv552767 CNV loss 21841781
nsv7632 CNV insertion 18451855

Variation tolerance for PSMD13 Gene

Residual Variation Intolerance Score: 53% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PSMD13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMD13
Leiden Open Variation Database (LOVD)
PSMD13

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMD13 Gene

Disorders for PSMD13 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PSMD13 Gene - From: COP

Disorder Aliases PubMed IDs
histrionic personality disorder
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PSMD13

genes like me logo Genes that share disorders with PSMD13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSMD13 Gene

Publications for PSMD13 Gene

  1. cDNA cloning and functional analysis of p28 (Nas6p) and p40.5 (Nas7p), two novel regulatory subunits of the 26S proteasome. (PMID: 9714768) Hori T … Tanaka K (Gene 1998) 2 3 4 22
  2. An atomic structure of the human 26S proteasome. (PMID: 27428775) Huang X … Shi Y (Nature structural & molecular biology 2016) 3 4
  3. Characterization of a bidirectional promoter shared between two human genes related to aging: SIRT3 and PSMD13. (PMID: 17059877) Bellizzi D … De Benedictis G (Genomics 2007) 3 22
  4. Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X … Huang L (Biochemistry 2007) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for PSMD13 Gene