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The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Two transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
PSMD13 (Proteasome 26S Subunit, Non-ATPase 13) is a Protein Coding gene. Diseases associated with PSMD13 include Histrionic Personality Disorder. Among its related pathways are Downstream signaling events of B Cell Receptor (BCR) and CDK-mediated phosphorylation and removal of Cdc6.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005198 | structural molecule activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000502 | proteasome complex | TAS,IDA | 17323924 |
GO:0005576 | extracellular region | TAS | -- |
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | CDK-mediated phosphorylation and removal of Cdc6 |
.93
.93
|
.80
.80
.78
.70
.47
.31
|
2 | RET signaling |
.92
|
.92
|
3 | HIV Life Cycle |
.64
|
.45
|
4 | Pathways of neurodegeneration - multiple diseases | ||
5 | Class I MHC mediated antigen processing and presentation |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000165 | MAPK cascade | TAS | -- |
GO:0000209 | protein polyubiquitination | TAS | -- |
GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
GO:0006511 | ubiquitin-dependent protein catabolic process | IBA | 21873635 |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c | · | 14d |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||||||||||||||
SP7: | |||||||||||||||||||||||||||||||||||||||||
SP8: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PSMD13 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PSMD13 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PSMD13 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Psmd13 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Psmd13 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | PSMD13 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | PSMD13 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | PSMD13 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | psmd13 30 |
|
||
Str.1435 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.3428 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | psmd13 30 31 |
|
OneToOne | |
zgc56377 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9211 30 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001651 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Rpn9 30 31 32 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | rpn-9 30 31 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RPN9 30 31 33 33 |
|
OneToOne | |
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0B00825g 30 |
|
||
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ADR191C 30 |
|
||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT4G19006 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os01g0511300 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne | |
Bread mold (Neurospora crassa) |
Ascomycetes | NCU02374 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rpn9 30 |
|
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1045288 | - |
p.Asn13Ser |
|||
rs1794108 | - |
p.Gly204Glu |
|||
rs1794109 | - |
p.Leu205Phe |
|||
rs28927679 | - |
p.Ser150Leu |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1010n100 | CNV | gain | 25217958 |
dgv1011n100 | CNV | gain | 25217958 |
dgv1012n100 | CNV | gain | 25217958 |
dgv1505n54 | CNV | gain | 21841781 |
esv32593 | CNV | loss | 17666407 |
esv3625060 | CNV | gain | 21293372 |
esv3625064 | CNV | gain | 21293372 |
nsv1052484 | CNV | gain | 25217958 |
nsv1069987 | CNV | deletion | 25765185 |
nsv467631 | CNV | gain | 19166990 |
nsv469921 | CNV | gain | 18288195 |
nsv516439 | CNV | loss | 19592680 |
nsv522596 | CNV | gain | 19592680 |
nsv527533 | CNV | gain | 19592680 |
nsv552762 | CNV | gain | 21841781 |
nsv552765 | CNV | gain | 21841781 |
nsv552766 | CNV | loss | 21841781 |
nsv552767 | CNV | loss | 21841781 |
nsv7632 | CNV | insertion | 18451855 |
Disorder | Aliases | PubMed IDs |
---|---|---|
histrionic personality disorder |
|
|