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The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 n... See more...
Aliases for PSMD13 Gene
Aliases for PSMD13 Gene
External Ids for PSMD13 Gene
- HGNC: 9558
- NCBI Entrez Gene: 5719
- Ensembl: ENSG00000185627
- OMIM®: 603481
- UniProtKB/Swiss-Prot: Q9UNM6
Previous GeneCards Identifiers for PSMD13 Gene
- GC11P000459
- GC11P000281
- GC11M000945
- GC11P000226
- GC11P000056
Summaries for PSMD13 Gene
-
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Two transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for PSMD13 Gene
PSMD13 (Proteasome 26S Subunit, Non-ATPase 13) is a Protein Coding gene. Diseases associated with PSMD13 include Histrionic Personality Disorder. Among its related pathways are RET signaling and CDK-mediated phosphorylation and removal of Cdc6.
UniProtKB/Swiss-Prot Summary for PSMD13 Gene
-
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
Additional gene information for PSMD13 Gene
- HGNC (9558)
- NCBI Entrez Gene (5719)
- Ensembl (ENSG00000185627)
- OMIM® (603481)
- UniProtKB/Swiss-Prot (Q9UNM6)
- Open Targets Platform(ENSG00000185627)
- Monarch Initiative
- Alliance of Genome Resources
- Search for PSMD13 at DataMed
- Search for PSMD13 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSMD13 Gene
Genomics for PSMD13 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PSMD13 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PSMD13 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PSMD13
- Top Transcription factor binding sites by QIAGEN in the PSMD13 gene promoter:
-
- aMEF-2
- Arnt
- COMP1
- HTF
- MEF-2
- MEF-2A
- Olf-1
- Pax-2
- Pax-2a
- RREB-1
Genomic Locations for PSMD13 Gene
Latest Assembly
- chr11:236,966-252,984
- (GRCh38/hg38)
- Size:
- 16,019 bases
- Orientation:
- Plus strand
Previous Assembly
- chr11:236,976-252,984
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 16,009 bases
- Orientation:
- Plus strand
Genomic View for PSMD13 Gene
Genes around PSMD13 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p15.5 by HGNC
- 11p15.5 by Entrez Gene
- 11p15.5 by Ensembl
PSMD13 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PSMD13 Gene
Proteins for PSMD13 Gene
-
Protein details for PSMD13 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UNM6-PSD13_HUMAN
- Recommended name:
- 26S proteasome non-ATPase regulatory subunit 13
- Protein Accession:
- Q9UNM6
- B3KT15
- O75831
- Q53XU2
- Q9UNV3
Protein attributes for PSMD13 Gene
- Size:
- 376 amino acids
- Molecular mass:
- 42945 Da
- Quaternary structure:
-
- Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD13, a base containing 6 ATPases and few additional components.
Three dimensional structures from OCA and Proteopedia for PSMD13 Gene
Protein Expression for PSMD13 Gene
Post-translational modifications for PSMD13 Gene
Other Protein References for PSMD13 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- G Biosciences Immunotag™ PSMD13 Antibody
-
Custom Antibody ServicesOriGene Antibodies for PSMD13
- Novus Biologicals Antibodies for PSMD13
-
Abcam antibodies for PSMD13
- Invitrogen Antibodies for PSMD13 (AFLGC-PSMD13)
-
Boster Bio Antibodies for PSMD13
- Sino Biological Antibodies for PSMD13
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for PSMD13
- Origene Custom Protein Services for PSMD13
- ProSpec Recombinant Proteins for PSMD13
-
Abcam proteins for PSMD13
Assay products for research
- antibodies-online: Show 10 available PSMD13 Elisa Kits ranked by validation data
- Compare Top PSMD13 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for PSMD13 Gene
Domains & Families for PSMD13 Gene
Gene Families for PSMD13 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for PSMD13 Gene
- InterPro:
- Blocks:
-
- Domain in components of the proteasome, COP9-complex and eIF3 (PCI)
Suggested Antigen Peptide Sequences for PSMD13 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ53046, highly similar to 26S proteasome non-ATPase regulatory subunit 13 (B4DJ66_HUMAN)
- 26S proteasome regulatory subunit p40.5 (PSD13_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9UNM6- Family:
-
- Belongs to the proteasome subunit S11 family.
Function for PSMD13 Gene
Molecular function for PSMD13 Gene
- UniProtKB/Swiss-Prot Function:
- Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
Phenotypes From GWAS Catalog for PSMD13 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005198 | structural molecule activity | IBA | 21873635 |
Phenotypes for PSMD13 Gene
- MGI mutant phenotypes for PSMD13:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PSMD13:
-
- Increased G1 DNA content
- Reduced mammosphere formation
- no effect
- Decreased viability
- Decreased vaccinia virus (VACV) infection
- Increased hepcidin::fluc mRNA expression
- Increased shRNA abundance (Z-score > 2)
- Increased IL-8 secretion
- Decreased shRNA abundance (Z-score < -2)
- Decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
- Increased caspase activity
- Increased circadian period length
- G0/1 arrest
- Two nuclei (binuclear)
- Decreased viability of wild-type and TP53 knockout cells, decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Increased Salmonella proliferation
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PSMD13 - Starting at $85 >
- * PSMD13 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PSMD13
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PSMD13
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSMD13
miRNA for PSMD13 Gene
- miRTarBase miRNAs that target PSMD13
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PSMD13
- Browse OriGene Inhibitory RNA Products For PSMD13
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMD13
Clone products for research
- Applied Biological Materials (abm): Clones for PSMD13 - Starting at $45 >
- * PSMD13 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for PSMD13
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PSMD13
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMD13 Gene
Localization for PSMD13 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 4 |
| cytosol | 4 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| peroxisome | 0 |
- Cytosol (2)
- Nuclear speckles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000502 | proteasome complex | TAS,IDA | 17323924 |
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005634 | nucleus | IBA | 21873635 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for PSMD13 Gene
Pathways & Interactions for PSMD13 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | CDK-mediated phosphorylation and removal of Cdc6 |
.93
.93
|
.80
.80
.78
.70
.47
.31
|
| 2 | RET signaling |
.92
|
.92
|
| 3 | HIV Life Cycle |
.64
|
.45
|
| 4 | Pathways of neurodegeneration - multiple diseases | ||
| 5 | Class I MHC mediated antigen processing and presentation | ||
Pathways by source for PSMD13 Gene
1 Sino Biological pathway for PSMD13 Gene
2 BioSystems pathways for PSMD13 Gene
9 KEGG pathways for PSMD13 Gene
3 GeneGo (Thomson Reuters) pathways for PSMD13 Gene
- Immune response Antigen presentation by MHC class I
- Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
- Transcription Ligand-Dependent Transcription of Retinoid-Target genes
2 Qiagen pathways for PSMD13 Gene
- RAR-Gamma-RXR-Alpha Degradation
- Remodeling of Adherens Junctions
Interacting Proteins for PSMD13 Gene
Selected Interacting proteins:
Q9UNM6-PSD13_HUMAN
ENSP00000396937
for PSMD13 Gene via
MINT
STRING
IID
GPS-Prot Interaction Network for PSMD13
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
| GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
| GO:0006511 | ubiquitin-dependent protein catabolic process | IBA | 21873635 |
No data available for SIGNOR curated interactions for PSMD13 Gene
Drugs & Compounds for PSMD13 Gene
Transcripts for PSMD13 Gene
mRNA/cDNA for PSMD13 Gene
- 2 REFSEQ mRNAs :
- 18 NCBI additional mRNA sequence :
- 15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000352303 1427 nts (view in UCSC)
- ENST00000382671 1489 nts (view in UCSC)
- ENST00000431206 1591 nts (view in UCSC)
- ENST00000525665 1632 nts (view in UCSC)
- ENST00000526783 892 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PSMD13 - Starting at $85 >
- * PSMD13 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PSMD13
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PSMD13
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSMD13
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PSMD13
- Browse OriGene Inhibitory RNA Products For PSMD13
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMD13
Clone products for research
- Applied Biological Materials (abm): Clones for PSMD13 - Starting at $45 >
- * PSMD13 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for PSMD13
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PSMD13
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c | · | 14d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||
| SP8: |
Relevant External Links for PSMD13 Gene
- GeneLoc Exon Structure for
- PSMD13
Expression for PSMD13 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
- Brain (Nervous System)
This gene is overexpressed in Peripheral blood mononuclear cells (7.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMD13 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PSMD13
SOURCE GeneReport for Unigene cluster for PSMD13 Gene:
Hs.134688Evidence on tissue expression from TISSUES for PSMD13 Gene
- Nervous system(4.9)
- Lung(4.7)
- Liver(4.5)
- Blood(4.5)
- Kidney(4.5)
- Skin(4)
- Intestine(2.6)
- Eye(2.6)
- Adrenal gland(2.4)
- Muscle(2.4)
- Pancreas(2.3)
- Heart(2.2)
Primer products for research
-
OriGene qPCR primer pairs for PSMD13
-
OriGene qPCR primer pairs and template standards for PSMD13
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMD13 Gene
Orthologs for PSMD13 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PSMD13 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PSMD13 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PSMD13 29 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Psmd13 29 |
|
||
| Mouse (Mus musculus) |
Mammalia | Psmd13 29 16 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | PSMD13 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | PSMD13 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | PSMD13 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 30 |
|
OneToMany | |
| -- 30 |
|
OneToMany | |||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | psmd13 29 |
|
||
| Str.1435 29 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.3428 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | psmd13 29 30 |
|
OneToOne | |
| zgc56377 29 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9211 29 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001651 29 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Rpn9 29 30 31 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | rpn-9 29 30 |
|
OneToOne | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RPN9 29 30 32 32 |
|
OneToOne | |
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0B00825g 29 |
|
||
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ADR191C 29 |
|
||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT4G19006 29 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os01g0511300 29 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 30 |
|
OneToOne | |
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU02374 29 |
|
||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rpn9 29 |
|
- Species where no ortholog for PSMD13 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for PSMD13 Gene
- ENSEMBL:
- Gene Tree for PSMD13 (if available)
- TreeFam:
- Gene Tree for PSMD13 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PSMD13: view image
- Alliance of Genome Resources:
- Additional Orthologs for PSMD13
Paralogs for PSMD13 Gene
(1) SIMAP similar genes for PSMD13 Gene using alignment to 8 proteins:
- PSD13_HUMAN
- B4DJ66_HUMAN
- E9PL38_HUMAN
- E9PPD2_HUMAN
- E9PQG3_HUMAN
- F8W8J6_HUMAN
- H0YD73_HUMAN
- J3KNQ3_HUMAN
No data available for Paralogs for PSMD13 Gene
Variants for PSMD13 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PSMD13 Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1045288 | -- |
p.Asn13Ser |
|||
| rs1794108 | -- |
p.Gly204Glu |
|||
| rs1794109 | -- |
p.Leu205Phe |
|||
| rs28927679 | -- |
p.Ser150Leu |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1010n100 | CNV | gain | 25217958 |
| dgv1011n100 | CNV | gain | 25217958 |
| dgv1012n100 | CNV | gain | 25217958 |
| dgv1505n54 | CNV | gain | 21841781 |
| esv32593 | CNV | loss | 17666407 |
| esv3625060 | CNV | gain | 21293372 |
| esv3625064 | CNV | gain | 21293372 |
| nsv1052484 | CNV | gain | 25217958 |
| nsv1069987 | CNV | deletion | 25765185 |
| nsv467631 | CNV | gain | 19166990 |
| nsv469921 | CNV | gain | 18288195 |
| nsv516439 | CNV | loss | 19592680 |
| nsv522596 | CNV | gain | 19592680 |
| nsv527533 | CNV | gain | 19592680 |
| nsv552762 | CNV | gain | 21841781 |
| nsv552765 | CNV | gain | 21841781 |
| nsv552766 | CNV | loss | 21841781 |
| nsv552767 | CNV | loss | 21841781 |
| nsv7632 | CNV | insertion | 18451855 |
Residual Variation Intolerance Score:
53% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.46;
28.56% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PSMD13 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMD13 Gene
Disorders for PSMD13 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| histrionic personality disorder |
|
|
Search PSMD13 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PSMD13
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PSMD13 Gene
Publications for PSMD13 Gene
- cDNA cloning and functional analysis of p28 (Nas6p) and p40.5 (Nas7p), two novel regulatory subunits of the 26S proteasome. (PMID: 9714768) Hori T … Tanaka K (Gene 1998) 2 3 4 22
- An atomic structure of the human 26S proteasome. (PMID: 27428775) Huang X … Shi Y (Nature structural & molecular biology 2016) 3 4
- Characterization of a bidirectional promoter shared between two human genes related to aging: SIRT3 and PSMD13. (PMID: 17059877) Bellizzi D … De Benedictis G (Genomics 2007) 3 22
- Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X … Huang L (Biochemistry 2007) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
ExternalLinks
Products for PSMD13 Gene
- Custom Antibody ServicesOriGene Antibodies for PSMD13
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for PSMD13
- Origene Custom Protein Services for PSMD13
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PSMD13
- Browse OriGene Inhibitory RNA Products For PSMD13
- OriGene qPCR primer pairs for PSMD13
- OriGene qPCR primer pairs and template standards for PSMD13
- OriGene CRISPR knockouts for PSMD13