Aliases for PSMD1 Gene
Aliases for PSMD1 Gene
External Ids for PSMD1 Gene
- HGNC: 9554
- Entrez Gene: 5707
- Ensembl: ENSG00000173692
- UniProtKB: Q99460
Previous GeneCards Identifiers for PSMD1 Gene
- GC02P229979
- GC02P230653
- GC02P231885
- GC02P232124
- GC02P231747
- GC02P231629
- GC02P231921
- GC02P223763
Summaries for PSMD1 Gene
-
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes the largest non-ATPase subunit of the 19S regulator lid, which is responsible for substrate recognition and binding. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2010]
GeneCards Summary for PSMD1 Gene
PSMD1 (Proteasome 26S Subunit, Non-ATPase 1) is a Protein Coding gene. Among its related pathways are RET signaling and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include binding and enzyme regulator activity.
UniProtKB/Swiss-Prot for PSMD1 Gene
-
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMD1 Gene
Genomics for PSMD1 Gene
GeneHancer (GH) Regulatory Elements for PSMD1 Gene
Promoters and enhancers for PSMD1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PSMD1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for PSMD1 Gene
Genomic Locations for PSMD1 Gene
- chr2:231,056,864-231,172,827
- (GRCh38/hg38)
- Size:
- 115,964 bases
- Orientation:
- Plus strand
- chr2:231,921,578-232,037,541
- (GRCh37/hg19)
Genomic View for PSMD1 Gene
Genes around PSMD1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q37.1 by Ensembl
- 2q37.1 by Entrez Gene
- 2q37.1 by HGNC
PSMD1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PSMD1 Gene
Proteins for PSMD1 Gene
-
Protein details for PSMD1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99460-PSMD1_HUMAN
- Recommended name:
- 26S proteasome non-ATPase regulatory subunit 1
- Protein Accession:
- Q99460
- B8ZZH9
- Q24JU0
- Q53TI2
- Q6GMU5
- Q6P2P4
- Q6PJM7
- Q6PKG9
- Q86VU1
- Q8IV79
Protein attributes for PSMD1 Gene
- Size:
- 953 amino acids
- Molecular mass:
- 105836 Da
- Quaternary structure:
-
- Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases and few additional components including PSMD1 (PubMed:27428775, PubMed:27342858). Interacts with ADRM1 (PubMed:16990800, PubMed:16906146).
- SequenceCaution:
-
- Sequence=AAH01053.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH14013.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH39845.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH47897.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH64398.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH73833.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for PSMD1 Gene
Protein Expression for PSMD1 Gene
Post-translational modifications for PSMD1 Gene
Other Protein References for PSMD1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for PSMD1
-
Abcam antibodies for PSMD1
- Invitrogen Antibodies for PSMD1
- Search GeneTex for Antibodies for PSMD1
-
Santa Cruz Biotechnology (SCBT) Antibodies for PSMD1
Protein Products
-
OriGene Purified Proteins for PSMD1
- Search Origene for MassSpec and Protein Over-expression Lysates for PSMD1
- Origene Custom Protein Services for PSMD1
- Search GeneTex for Proteins for PSMD1
-
Abcam proteins for PSMD1
Assay Products
- antibodies-online: Search results for 12 available Ribophorin II Elisa Kits ranked by validation data
- Compare Top Ribophorin II Elisa Kits
-
Recommended
- 1 Sheep (Ovine) ELISA Kit
- 1 Rat (Rattus) ELISA Kit
- 1 Rabbit ELISA Kit
- 1 Pig (Porcine) ELISA Kit
- 1 Mouse (Murine) ELISA Kit
- 1 Monkey ELISA Kit
- 1 Human ELISA Kit
- 1 Guinea Pig ELISA Kit
- 1 Goat ELISA Kit
- 1 Dog (Canine) ELISA Kit
- 1 Cow (Bovine) ELISA Kit
- 1 Chicken ELISA Kit
- 1 Sheep (Ovine) ELISA Kit
- 1 Rat (Rattus) ELISA Kit
- 1 Rabbit ELISA Kit
- 1 Pig (Porcine) ELISA Kit
- 1 Mouse (Murine) ELISA Kit
- 1 Monkey ELISA Kit
- 1 Human ELISA Kit
- 1 Guinea Pig ELISA Kit
- 1 Goat ELISA Kit
- 1 Dog (Canine) ELISA Kit
- 1 Cow (Bovine) ELISA Kit
- 1 Chicken ELISA Kit
No data available for DME Specific Peptides for PSMD1 Gene
Domains & Families for PSMD1 Gene
Gene Families for PSMD1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for PSMD1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PSMD1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q99460- Family:
-
- Belongs to the proteasome subunit S1 family.
Function for PSMD1 Gene
Molecular function for PSMD1 Gene
- GENATLAS Biochemistry:
- multicatalytic proteinase complex (prosome,macropain,26S),19/22S regulator of proteasome,non ATPase subunit,p112-L (105kDa) and p112-S (90kDa)
- UniProtKB/Swiss-Prot Function:
- Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
Phenotypes From GWAS Catalog for PSMD1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004175 | contributes_to endopeptidase activity | IBA | -- |
| GO:0030234 | enzyme regulator activity | IEA | -- |
Phenotypes for PSMD1 Gene
- GenomeRNAi human phenotypes for PSMD1:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased viability
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability in esophageal squamous lineage
- Dynamic nuclei (hole, folded or small irregular)
- Decreased NF-kappaB reporter expression
- FOXO1 nuclear localization
- Decreased viability with paclitaxel
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Decreased cell number
- Decreased homologous recombination repair frequency
- Negative genetic interaction between BLM-/- and BLM+/+
- Decreased Hepatitis C virus replication
- Decreased Salmonella proliferation
- Decreased viability of wild-type and TP53 knockout cells
- Increased Sindbis virus (SINV) infection
- Upregulation of RLR pathway after Sendai virus (SeV) infection
- Downregulation of NFkappaB pathway
- HIV Rev nuclear localization
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PSMD1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for PSMD1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PSMD1 gene
- Search ViGene Biosciences for PSMD1
CRISPR Products
-
OriGene CRISPR knockouts for PSMD1
- Applied Biological Materials CRISPR for PSMD1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSMD1
- GenScript: Design CRISPR guide RNA sequences for PSMD1
miRNA for PSMD1 Gene
- miRTarBase miRNAs that target PSMD1
-
- hsa-mir-24-3p (MIRT030387)
- hsa-mir-1180-3p (MIRT035921)
- hsa-mir-423-3p (MIRT042491)
- hsa-mir-346 (MIRT042702)
- hsa-mir-331-3p (MIRT043445)
- hsa-mir-149-5p (MIRT045451)
- hsa-mir-744-3p (MIRT666786)
- hsa-mir-6848-3p (MIRT666787)
- hsa-mir-6843-3p (MIRT666788)
- hsa-mir-8057 (MIRT666789)
- hsa-mir-4423-5p (MIRT666790)
- hsa-mir-6501-5p (MIRT666791)
- hsa-mir-4284 (MIRT666792)
- hsa-mir-6131 (MIRT666793)
- hsa-mir-3663-5p (MIRT666794)
- hsa-mir-372-5p (MIRT666795)
- hsa-mir-371a-5p (MIRT666796)
- hsa-mir-616-5p (MIRT666797)
- hsa-mir-373-5p (MIRT666798)
- hsa-mir-371b-5p (MIRT666799)
- hsa-mir-3189-3p (MIRT666800)
- hsa-mir-212-5p (MIRT666801)
miRNA Products
- Search ViGene Biosciences for PSMD1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PSMD1
- Browse OriGene Inhibitory RNA Products For PSMD1
- genomics-online: shRNA clones - Search results for 128 available Ribophorin II gene related products
- Overview of 128 available Ribophorin II gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PSMD1 gene
Clone Products
- Sino Biological Human cDNA Clone for PSMD1
- VectorBuilder custom plasmid, inducible vectors for PSMD1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PSMD1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PSMD1
- genomics-online: cdna clones - Search results for 128 available Ribophorin II gene related products
- Overview of 128 available Ribophorin II gene related products
- orf clones - Search results for 128 available Ribophorin II gene related products
- Overview of 128 available Ribophorin II gene related products
- Applied Biological Materials Clones for PSMD1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for PSMD1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PSMD1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PSMD1 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMD1 Gene
Localization for PSMD1 Gene
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 5 |
| lysosome | 4 |
| cytoskeleton | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
- Actin filaments (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000502 | proteasome complex | IEA,IDA | 17323924 |
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005634 | nucleus | IBA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for PSMD1 Gene
Pathways & Interactions for PSMD1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | CDK-mediated phosphorylation and removal of Cdc6 |
.93
.93
|
.80
.78
.78
.70
.47
.31
|
| 2 | RET signaling |
.92
|
.92
|
| 3 | Chks in Checkpoint Regulation | ||
| 4 | HIV Life Cycle |
.65
|
.45
|
| 5 | Class I MHC mediated antigen processing and presentation | ||
Pathways by source for PSMD1 Gene
1 Sino Biological pathway for PSMD1 Gene
2 BioSystems pathways for PSMD1 Gene
2 KEGG pathways for PSMD1 Gene
3 GeneGo (Thomson Reuters) pathways for PSMD1 Gene
19 Qiagen pathways for PSMD1 Gene
Interacting Proteins for PSMD1 Gene
Selected Interacting proteins:
ENSP00000309474
Q99460-PSMD1_HUMAN
for PSMD1 Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
| GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
| GO:0006521 | regulation of cellular amino acid metabolic process | TAS | -- |
No data available for SIGNOR curated interactions for PSMD1 Gene
Drugs & Compounds for PSMD1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Bortezomib | Approved, Investigational | Pharma | inhibitor, other | Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors | 826 | |
| carfilzomib | Approved, Investigational | Pharma | other, Inhibitor | Other, 20S Proteasome Inhibitor | 0 | |
| Oprozomib | Investigational | Pharma | 0 | |||
| MLN-9708 | Pharma | 0 |
Transcripts for PSMD1 Gene
mRNA/cDNA for PSMD1 Gene
- (3) REFSEQ mRNAs :
- (16) Additional mRNA sequences :
- (535) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PSMD1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for PSMD1
- Applied Biological Materials CRISPR for PSMD1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSMD1
- GenScript: Design CRISPR guide RNA sequences for PSMD1
miRNA Products
- Search ViGene Biosciences for PSMD1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PSMD1
- Browse OriGene Inhibitory RNA Products For PSMD1
- genomics-online: shRNA clones - Search results for 128 available Ribophorin II gene related products
- Overview of 128 available Ribophorin II gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PSMD1 gene
Clone Products
- Sino Biological Human cDNA Clone for PSMD1
- VectorBuilder custom plasmid, inducible vectors for PSMD1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PSMD1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PSMD1
- genomics-online: cdna clones - Search results for 128 available Ribophorin II gene related products
- Overview of 128 available Ribophorin II gene related products
- orf clones - Search results for 128 available Ribophorin II gene related products
- Overview of 128 available Ribophorin II gene related products
- Applied Biological Materials Clones for PSMD1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for PSMD1 Gene
This gene is overexpressed in Lymph node (8.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSMD1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of PSMD1 Gene:
PSMD1SOURCE GeneReport for Unigene cluster for PSMD1 Gene:
Hs.3887Evidence on tissue expression from TISSUES for PSMD1 Gene
- Nervous system(4.8)
- Liver(4.4)
- Lung(3.9)
- Kidney(3)
- Heart(2.6)
- Eye(2.2)
Primer Products
-
OriGene qPCR primer pairs for PSMD1
-
OriGene qPCR primer pairs and template standards for PSMD1
- genomics-online: primer clones - Search results for 128 available Ribophorin II gene related products
- Overview of 128 available Ribophorin II gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMD1 Gene
Orthologs for PSMD1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PSMD1 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PSMD1 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Gm21972 34 |
|
OneToMany | |
| Psmd1 33 16 34 |
|
||||
| cow (Bos Taurus) |
Mammalia | PSMD1 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | PSMD1 33 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | PSMD1 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Psmd1 33 |
|
||
| chicken (Gallus gallus) |
Aves | PSMD1 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | PSMD1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | psmd1 33 |
|
||
| Str.6698 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | psmd1 33 34 |
|
||
| zgc55818 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Rpn2 35 33 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001745 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | rpn-2 34 |
|
OneToOne | |
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ACL033C 33 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0C09284g 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RPN2 34 36 33 |
|
OneToOne | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT1G04810 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os08g0224700 33 |
|
||
| Os.15239 33 |
|
||||
| corn (Zea mays) |
Liliopsida | Zm.4098 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3236 34 |
|
OneToOne | |
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rpn2 33 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU09450 33 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.12342 33 |
|
- Species where no ortholog for PSMD1 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for PSMD1 Gene
No data available for Paralogs for PSMD1 Gene
Variants for PSMD1 Gene
| SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000012769 | -- | 231,126,126(+) | G/A | genic_downstream_transcript_variant, intron_variant | |
| rs1000020354 | -- | 231,079,713(+) | A/G | intron_variant | |
| rs1000023009 | -- | 231,123,042(+) | G/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000036910 | -- | 231,058,018(+) | G/A | intron_variant | |
| rs1000044502 | -- | 231,100,087(+) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv2169n106 | CNV | deletion | 24896259 |
| dgv4181n100 | CNV | loss | 25217958 |
| esv1919954 | CNV | deletion | 18987734 |
| esv2245776 | CNV | deletion | 18987734 |
| esv2630508 | CNV | deletion | 19546169 |
| esv2721610 | CNV | deletion | 23290073 |
| esv3307622 | CNV | mobile element insertion | 20981092 |
| esv3339619 | CNV | insertion | 20981092 |
| esv3561143 | CNV | deletion | 23714750 |
| esv3561144 | CNV | deletion | 23714750 |
| esv4723 | CNV | loss | 18987735 |
| nsv1109336 | CNV | deletion | 24896259 |
| nsv1114177 | CNV | deletion | 24896259 |
| nsv1148926 | CNV | deletion | 26484159 |
| nsv214090 | CNV | deletion | 16902084 |
| nsv511843 | CNV | loss | 21212237 |
| nsv524208 | CNV | gain | 19592680 |
| nsv525474 | CNV | loss | 19592680 |
Residual Variation Intolerance Score:
11.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.82;
34.22% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PSMD1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PSMD1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMD1 Gene
Disorders for PSMD1 Gene
Additional Disease Information for PSMD1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for PSMD1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMD1 Gene
Publications for PSMD1 Gene
- CDNA cloning of p112, the largest regulatory subunit of the human 26s proteasome, and functional analysis of its yeast homologue, sen3p. (PMID: 8816993) Yokota K … Tanaka K (Molecular biology of the cell 1996) 2 3 4 22 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
- Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X … Huang L (Biochemistry 2007) 3 4 58
- A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes. (PMID: 16990800) Hamazaki J … Murata S (The EMBO journal 2006) 3 4 58
Products for PSMD1 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays