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The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12. [provided by RefSeq, Jul 2008]
PSMC6 (Proteasome 26S Subunit, ATPase 6) is a Protein Coding gene. Diseases associated with PSMC6 include Cystic Fibrosis and Ehrlichiosis. Among its related pathways are Downstream signaling events of B Cell Receptor (BCR) and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include hydrolase activity and protein binding, bridging. An important paralog of this gene is PSMC5.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0005515 | protein binding | IPI | 16189514 |
GO:0005524 | ATP binding | IEA | -- |
GO:0016787 | hydrolase activity | IEA | -- |
GO:0016887 | ATPase activity | IEA,TAS | 9464850 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000502 | proteasome complex | IEA,IDA | 9464850 |
GO:0005634 | nucleus | IEA,IDA | 10419517 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | CDK-mediated phosphorylation and removal of Cdc6 |
.93
.93
|
.80
.80
.78
.70
.47
.31
|
2 | RET signaling |
.92
|
.92
|
3 | Chks in Checkpoint Regulation |
Chks in Checkpoint Regulation
.59
G2-M Phase Transition
.59
Estrogen-mediated S-Phase Entry
.55
|
SREBP Proteolysis
.43
DNA Repair Mechanisms
.32
Parkinson's Disease Pathway
.31
|
4 | HIV Life Cycle |
.64
|
.45
|
5 | Pathways of neurodegeneration - multiple diseases |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000165 | MAPK cascade | TAS | -- |
GO:0000209 | protein polyubiquitination | TAS | -- |
GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
GO:0006511 | ubiquitin-dependent protein catabolic process | IC | 9464850 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PSMC6 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | PSMC6 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PSMC6 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PSMC6 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | PSMC6 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Psmc6 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Psmc6 30 |
|
||
Chicken (Gallus gallus) |
Aves | PSMC6 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | PSMC6 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | psmc6 30 |
|
||
MGC76159 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.3381 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | psmc6 30 31 |
|
OneToOne | |
Dr.29047 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8441 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG7257 32 |
|
|
|
Rpt4R 31 |
|
OneToMany | |||
Rpt4 30 31 32 |
|
OneToMany | |||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001407 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | rpt-4 30 31 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RPT4 30 31 |
|
OneToOne | |
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0C09592g 30 |
|
||
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AAL113W 30 |
|
||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | RPT4A 30 |
|
||
Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.5748 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os02g0199900 30 |
|
||
Os.292 30 |
|
||||
Barley (Hordeum vulgare) |
Liliopsida | Hv.5889 30 |
|
||
Wheat (Triticum aestivum) |
Liliopsida | Ta.14349 30 |
|
||
Corn (Zea mays) |
Liliopsida | Zm.3972 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.3434 31 |
|
OneToOne | |
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rpt4 30 |
|
||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU07367 30 |
|
||
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.11771 30 |
|
SNP ID | Clinical significance and condition | Chr 14 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs199988613 | Likely Benign: not provided | 52,707,216(+) |
C/T NM_002806.5(PSMC6):c.-4C>T |
NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR |
Disorder | Aliases | PubMed IDs |
---|---|---|
cystic fibrosis |
|
|
ehrlichiosis |
|
|
pheochromocytoma |
|
|