PSMC6 Gene (Protein Coding)

Proteasome 26S Subunit, ATPase 6

GCID:: GC14P052707

GIFtS:: 42

Genes Participants

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 n... See more...

Aliases for PSMC6 Gene

Proteasome 26S Subunit, ATPase 6 ² ³ ⁵
Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 6 ² ³
26S Proteasome AAA-ATPase Subunit RPT4 ³ ⁴
26S Proteasome Regulatory Subunit 10B ³ ⁴
Proteasome Subunit P42 ³ ⁴
SUG2 ³ ⁴
Proteasome 26S Subunit ATPase 6 ⁴
P42 ³

External Ids for PSMC6 Gene

HGNC: 9553
Entrez Gene: 5706
Ensembl: ENSG00000100519
OMIM: 602708
UniProtKB: P62333

Previous GeneCards Identifiers for PSMC6 Gene

GC14P050496
GC14P046969
GC14P051163
GC14P052243
GC14P053173
GC14P033334

Search aliases for PSMC6 gene in PubMed and other databases

Summaries for PSMC6 Gene

Entrez Gene Summary for PSMC6 Gene

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12. [provided by RefSeq, Jul 2008]

GeneCards Summary for PSMC6 Gene

PSMC6 (Proteasome 26S Subunit, ATPase 6) is a Protein Coding gene. Diseases associated with PSMC6 include Cystic Fibrosis and Pheochromocytoma. Among its related pathways are Metabolism of proteins and RET signaling. Gene Ontology (GO) annotations related to this gene include hydrolase activity and protein binding, bridging. An important paralog of this gene is PSMC5.

UniProtKB/Swiss-Prot Summary for PSMC6 Gene

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC6 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
- PRS10_HUMAN,P62333

Gene Wiki entry for PSMC6 Gene

Additional gene information for PSMC6 Gene

Search for PSMC6 at DataMed
Search for PSMC6 at HumanCyc

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSMC6 Gene

Genomics for PSMC6 Gene

GeneHancer (GH) Regulatory Elements for PSMC6 Gene

Promoters and enhancers for PSMC6 Gene

GeneHancer (GH) Identifier	GH Type	GH Score	GH Sources	Gene Association Score	Total Score	TSS distance (kb)	Number of Genes Away	Size (kb)	Transcription Factor Binding Sites
GH14J052706	Promoter/Enhancer	2	EPDnew Ensembl ENCODE CraniofacialAtlas	500.7	+0.2	238	2.8	ZBTB40 ZNF217 EP300 SIN3A TCF12 POLR2G SP1 GTF2E2 PHF8 ZFX	PSMC6 lnc-ERO1A-2 STYX HSALNG0101302
GH14J051980	Enhancer	1	Ensembl ENCODE dbSUPER	9.7	-728.0	-727962	0.8	CTCF TEAD4 REST RAD21 TRIM22 SMC3 YY1 MAFK RCOR1 SMARCA5	ENSG00000271075 FRMD6 PSMC6 TMX1 ENSG00000258854 ENSG00000259007 GNG2
GH14J052337	Enhancer	0.7	Ensembl	9.8	-368.6	-368562	1.6	FOXK2 EP300 ZNF300 ZNF282 FOSL2 PLRG1 ZNF112 ZNF621 STAT3 FOXA1	RF00017-1551 ENSG00000271075 FRMD6 PSMC6 PTGER2 piR-48759-087
GH14J052740	Enhancer	0.5	ENCODE	11.4	+35.0	34959	3	ZBTB40 SPI1 ELF1 TBP GATA2 PKNOX1 ARID3A MLLT1 RUNX3 RELB	STYX PSMC6 ERO1A piR-57460-185 lnc-PSMC6-1
GH14J052711	Enhancer	0.3	Ensembl	0.7	+4.2	4238	0.8	PRDM6 RBFOX2	HSALNG0101302 STYX PSMC6 RF00017-1553

- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSMC6 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PSMC6

Top Transcription factor binding sites by QIAGEN in the PSMC6 gene promoter:

AhR
aMEF-2
AREB6
Bach2
GATA-1
HNF-4alpha1
HNF-4alpha2
LCR-F1
MEF-2A
Pax-5

Genomic Locations for PSMC6 Gene

chr14:52,707,163-52,728,590: (GRCh38/hg38)

Size:: 21,428 bases
Orientation:: Plus strand

chr14:53,173,890-53,195,305: (GRCh37/hg19)

Size:: 21,416 bases
Orientation:: Plus strand

Genomic View for PSMC6 Gene

Genes around PSMC6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:

14q22.1 by HGNC
14q22.1 by Entrez Gene
14q22.1 by Ensembl

PSMC6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

Genomic Location for PSMC6 Gene — Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PSMC6 Gene

NC_000014.9

Proteins for PSMC6 Gene

Protein details for PSMC6 Gene (UniProtKB/Swiss-Prot)
Protein Symbol:

P62333-PRS10_HUMAN

Recommended name:

26S proteasome regulatory subunit 10B

Protein Accession:

P62333

Secondary Accessions:
- B2R975
- P49719
- Q6IBU3
- Q92524
Protein attributes for PSMC6 Gene
Size:

389 amino acids

Molecular mass:

44173 Da
Quaternary structure:
Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC6 and few additional components (PubMed:27428775, PubMed:27342858). Interacts with PAAF1 (PubMed:15831487).
Three dimensional structures from OCA and Proteopedia for PSMC6 Gene
- 5GJQ (3D)
- 5GJR (3D)
- 5L4G (3D)
- 5LN3 (3D)
- 5M32 (3D)
- 5T0C (3D)

neXtProt entry for PSMC6 Gene

Protein Expression for PSMC6 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for PSMC6 Gene

Ubiquitination at Lys7, Lys20, Lys48, Lys168, Lys180, Lys197, Lys206, Lys274, Lys298, Lys314, Lys322, Lys333, and Lys369
- NX_P62333 (NX_P62333-1)
Modification sites at PhosphoSitePlus
- P62333

Other Protein References for PSMC6 Gene

ENSEMBL proteins:

REFSEQ proteins:

Antibody Products

G Biosciences Immunotag™ PSMC6 Antibody

Creative Diagnostics Anti-PSMC6 monoclonal antibody, clone 3D5

Creative Biolabs Recombinant Anti-Human PSMC6 Antibody and Recombinant Mouse anti-Human PSMC6 Monoclonal antibody (2C6)

OriGene Antibodies for PSMC6
- TA308946
- TA312060
- TA332653
- TA342589
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Novus Biologicals Antibodies for PSMC6

Abcam antibodies for PSMC6
- PSMC6

Invitrogen Antibodies for PSMC6 (AFLGC-PSMC6)

antibodies-online: Show 21 available PSMC6 Antibodies ranked by validation data
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Recommended

Biorbyt antibodies for PSMC6

Boster Bio Antibodies for PSMC6
- M09249

Santa Cruz Biotechnology (SCBT) Antibodies for PSMC6
- PSMC6 (34-Q)

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Protein Products

OriGene Purified Proteins for PSMC6
- NM_002806
- NM_002806
- NM_002806
- NM_002806
- NM_002806
- NM_002806
- NM_025959
- NM_002806
Search Origene for MassSpec and Protein Over-expression Lysates for PSMC6
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Novus Biologicals proteins and lysates for PSMC6

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antibodies-online: Show 10 available PSMC6 Proteins ranked by validation data
Compare Top PSMC6 Proteins

Signalway Proteins for PSMC6
- GP12956

ProSci Proteins for PSMC6
- proteasome (prosome, macropain) 26S subunit, ATPase, 6

Abcam proteins for PSMC6
- PSMC6

Assay Products

antibodies-online: Search results for available PSMC6 related products ranked by validation data

Browse Boster Bio ELISA Kits

Search for PSMC6 ELISA kits at Signalway

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No data available for DME Specific Peptides for PSMC6 Gene

Domains & Families for PSMC6 Gene

Gene Families for PSMC6 Gene

HGNC:

Human Protein Atlas (HPA):

Predicted intracellular proteins

Protein Domains for PSMC6 Gene

Blocks:

AAA-protein subdomain

InterPro:

ProtoNet:

P62333

Suggested Antigen Peptide Sequences for PSMC6 Gene

GenScript: Design optimal peptide antigens:

cDNA FLJ57570, highly similar to 26S protease regulatory subunit S10B (B4DR91_HUMAN)
Proteasome subunit p42 (PRS10_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P62333

UniProtKB/Swiss-Prot:

PRS10_HUMAN :

Belongs to the AAA ATPase family.

Family:

Belongs to the AAA ATPase family.

Function for PSMC6 Gene

Molecular function for PSMC6 Gene

UniProtKB/Swiss-Prot Function:

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC6 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.

PRS10_HUMAN,P62333

GENATLAS Biochemistry:

multicatalytic proteinase complex (prosome,macropain,26kDa) 19/22S regulator of proteasome p42,ATPase subunit,44kDa

PSMC6

Phenotypes From GWAS Catalog for PSMC6 Gene

Gene Ontology (GO) - Molecular Function for PSMC6 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005515	protein binding	IPI	16189514
GO:0005524	ATP binding	IEA	--
GO:0016787	hydrolase activity	IEA	--
GO:0016887	ATPase activity	IEA,TAS	9464850

Phenotypes for PSMC6 Gene

MGI mutant phenotypes for PSMC6:

inferred from 1 alleles

GenomeRNAi human phenotypes for PSMC6:

Animal Models for PSMC6 Gene

MGI Knock Outs for PSMC6:

Psmc6 ^{Psmc6<tm1b(KOMP)Wtsi>}

Animal Model Products

Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study

CRISPR Products

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Santa Cruz Biotechnology (SCBT) CRISPR for PSMC6

miRNA for PSMC6 Gene

miRTarBase miRNAs that target PSMC6

hsa-mir-26b-5p (MIRT028910)

miRNA Products

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Inhibitory RNA Products

Origene shrna, sirna, and RNAi products in human, mouse, rat for PSMC6
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Clone Products

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OriGene clones in human,mouse,rat for PSMC6
- SC205222
- MC210485
- RN200871
- SC118427
- SC320812
- SC327828
OriGene ORF clones in human,mouse,rat for PSMC6
- MG222069
- MR222069
- MR222069L3
- MR222069L4
- RC202809
- RC202809L1
- RC202809L2
- RC202809L3
- RC202809L4
- RC229193
- RC229193L1
- RC229193L3
- RG202809
- RG229193
- RR200871
- RR200871L3
- RR200871L4
- MR222069L3V
- MR222069L4V
- RC202809L1V
- RC202809L2V
- RC202809L3V
- RC202809L4V
- RC229193L1V
- RC229193L3V
- RR200871L3V
- RR200871L4V
Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling

Sino Biological Human cDNA Clone for PSMC6

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Cell Line Products

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VectorBuilder Stable cell line generation for PSMC6

Search Horizon for Cell Lines for PSMC6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PSMC6 Gene

Localization for PSMC6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMC6 Gene

Cytoplasm. Nucleus.

P62333-PRS10_HUMAN

Subcellular locations from

COMPARTMENTS

Compartment	Confidence
nucleus	5
cytosol	5
plasma membrane	3
extracellular	2
cytoskeleton	2
mitochondrion	2
peroxisome	2
endoplasmic reticulum	1
endosome	1
lysosome	1
golgi apparatus	1

Subcellular locations from the

Human Protein Atlas (HPA)

Cytosol (2)
Nucleoplasm (2)
Plasma membrane (2)

See all subcellular structures

Gene Ontology (GO) - Cellular Components for PSMC6 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000502	proteasome complex	IEA,IDA	9464850
GO:0005634	nucleus	IDA,IEA	10419517
GO:0005654	nucleoplasm	TAS	--
GO:0005737	cytoplasm	IEA	--
GO:0005829	cytosol	TAS	--

Pathways & Interactions for PSMC6 Gene

SuperPathways for PSMC6 Gene

	SuperPathway	Contained pathways
1	CDK-mediated phosphorylation and removal of Cdc6	Activation of APC/C and APC/C-Cdc20 mediated degradation of mitotic proteins .95 Cdc20-Phospho-APC/C mediated degradation of Cyclin A .95 Autodegradation of the E3 ubiquitin ligase COP1 .95 Stabilization of p53 .95 Regulation of activated PAK-2p34 by proteasome mediated degradation .94 Regulation of Apoptosis .94 CDK-mediated phosphorylation and removal of Cdc6 .94 Ubiquitin-dependent degradation of Cyclin D .94 Ubiquitin-dependent degradation of Cyclin D1 .94 Orc1 removal from chromatin .94 Regulation of DNA replication .94 Switching of origins to a post-replicative state .94 Cyclin A-Cdk2-associated events at S phase entry .93 Cyclin E associated events during G1/S transition .93 APC/C-Cdc20 mediated degradation of Securin .93 APC/C-Cdh1 mediated degradation of Cdc20 and other APC/C-Cdh1 targeted proteins in late mitosis/early G1 .93 APC/C-mediated degradation of cell cycle proteins .93 Regulation of APC/C activators between G1/S and early anaphase .93 Regulation of mitotic cell cycle .93 DNA Replication .93 Synthesis of DNA .93 Vpu mediated degradation of CD4 .93 Autodegradation of Cdh1 by Cdh1-APC/C .91 SCF-beta-TrCP mediated degradation of Emi1 .91 p53-Independent DNA Damage Response .91 p53-Independent G1/S DNA damage checkpoint .91 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A .91 ABC transporter disorders .91 Disorders of transmembrane transporters .91 Defective CFTR causes cystic fibrosis .90 Assembly of the pre-replicative complex .90 Hedgehog ligand biogenesis .90 Hh mutants abrogate ligand secretion .90 APC/C-Cdc20 mediated degradation of mitotic proteins .89 APC-Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint .89 Vif-mediated degradation of APOBEC3G .89 Degradation of GLI1 by the proteasome .89 Degradation of GLI2 by the proteasome .89 GLI3 is processed to GLI3R by the proteasome .89 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis .88	Degradation of AXIN .88 Cellular response to hypoxia .87 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha .87 Regulation of Hypoxia-inducible Factor (HIF) by oxygen .87 CDT1 association with the CDC6-ORC-origin complex .87 Hh mutants that dont undergo autocatalytic processing are degraded by ERAD .87 AUF1 (hnRNP D0) binds and destabilizes mRNA .86 p53-Dependent G1 DNA Damage Response .86 p53-Dependent G1/S DNA damage checkpoint .86 SCF(Skp2)-mediated degradation of p27/p21 .86 Removal of licensing factors from origins .86 NIK-->noncanonical NF-kB signaling .85 Dectin-1 mediated noncanonical NF-kB signaling .84 G1/S DNA Damage Checkpoints .84 Degradation of DVL .83 Cross-presentation of soluble exogenous antigens (endosomes) .82 The role of GTSE1 in G2/M progression after G2 checkpoint .81 Regulation of ornithine decarboxylase (ODC) .81 DNA Replication Pre-Initiation .80 M/G1 Transition .80 Proteasome .78 S Phase .78 Activation of NF-kappaB in B cells .77 Asymmetric localization of PCP proteins .74 FCERI mediated NF-kB activation .72 Regulation of RAS by GAPs .70 PCP/CE pathway .70 Beta-catenin independent WNT signaling .64 Degradation of beta-catenin by the destruction complex .64 Regulation of mRNA stability by proteins that bind AU-rich elements .63 Metabolism of polyamines .60 ABC-family proteins mediated transport .58 TNFR2 non-canonical NF-kB pathway .58 MAPK6/MAPK4 signaling .57 Proteasome Degradation .56 UCH proteinases .47 Canonical Wnt Pathway .32 Apoptosis .31 Programmed Cell Death .31
2	RET signaling	Frs2-mediated activation .95 GRB2 events in EGFR signaling .95 MAPK1/MAPK3 signaling .95 Prolonged ERK activation events .95 RAF/MAP kinase cascade .95 SHC1 events in EGFR signaling .95 Signaling by Leptin .95 SOS-mediated signalling .95 VEGFR2 mediated cell proliferation .95 ARMS-mediated activation .95 Signalling to ERKs .95 Signalling to p38 via RIT and RIN .95 Signalling to RAS .95 Interleukin receptor SHC signaling .95 Interleukin-3, 5 and GM-CSF signaling .94 Interleukin-2 signaling .94 Downstream signal transduction .94 Signaling by PDGF .94 DAP12 signaling .92	RET signaling .92 Insulin receptor signalling cascade .92 Signaling by Insulin receptor .92 IRS-mediated signalling .91 Signaling by EGFR .90 FCERI mediated MAPK activation .90 IGF1R signaling cascade .90 IRS-related events triggered by IGF1R .90 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) .90 DAP12 interactions .89 NCAM signaling for neurite out-growth .89 NGF signalling via TRKA from the plasma membrane .87 MAPK family signaling cascades .87 Signaling by SCF-KIT .85 Signalling by NGF .81 Fc epsilon receptor (FCERI) signaling .79 VEGFA-VEGFR2 Pathway .78 Signaling by VEGF .76 Gastrin-CREB signalling pathway via PKC and MAPK .55
3	Chks in Checkpoint Regulation	Chks in Checkpoint Regulation .59 G2-M Phase Transition .59 Estrogen-mediated S-Phase Entry .55	SREBP Proteolysis .43 DNA Repair Mechanisms .32 Parkinson's Disease Pathway .31
4	HIV Life Cycle	HIV Infection .64 Infectious disease .61 Host Interactions of HIV factors .57	Disease .45 Diseases of signal transduction .43
5	Class I MHC mediated antigen processing and presentation	Antigen processing- Ubiquitination and Proteasome degradation .83 Class I MHC mediated antigen processing and presentation .83	Adaptive Immune System .45

Pathways by source for PSMC6 Gene

1 Sino Biological pathway for PSMC6 Gene

Canonical Wnt Pathway

2 BioSystems pathways for PSMC6 Gene

164 Reactome pathways for PSMC6 Gene

2 KEGG pathways for PSMC6 Gene

3 GeneGo (Thomson Reuters) pathways for PSMC6 Gene

Immune response Antigen presentation by MHC class I
Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
Transcription Ligand-Dependent Transcription of Retinoid-Target genes

19 Qiagen pathways for PSMC6 Gene

CDK5 Pathway
Chks in Checkpoint Regulation
DNA Repair Mechanisms
Estrogen-mediated S-Phase Entry
G2-M Phase Transition

Interacting Proteins for PSMC6 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)

Selected Interacting proteins: P62333-PRS10_HUMAN ENSP00000401802 for PSMC6 Gene via UniProtKB MINT STRING IID

Symbol	External ID(s)	Details
PSMC5	P62195 ⁴ ²⁰ ¹²⁷ ENSP00000310572 ²¹	EBI-357669, EBI-357745 MINT-2794152 STRING: ENSP00000310572 IID: # exp=8 # pred=4
PSMD9	O00233 ⁴ ²⁰ ¹²⁷ ENSP00000440485 ²¹	EBI-357669, EBI-750973 MINT-8164752 STRING: ENSP00000440485 IID: # exp=8 # pred=3
CDC5L	Q99459 ²⁰ ¹²⁷ ENSP00000360532 ²¹	MINT-7947479 STRING: ENSP00000360532 IID: # exp=1
CRK	P46108 ⁴ ¹²⁷ ENSP00000300574 ²¹	EBI-357669, EBI-886 STRING: ENSP00000300574 IID: # exp=2
CYB5R2	Q6BCY4 ⁴ ¹²⁷ ENSP00000437041 ²¹	EBI-357669, EBI-744761 STRING: ENSP00000437041 IID: # exp=1

GPS-Prot Interaction Network for PSMC6

;

Gene Ontology (GO) - Biological Process for PSMC6 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000165	MAPK cascade	TAS	--
GO:0000209	protein polyubiquitination	TAS	--
GO:0002223	stimulatory C-type lectin receptor signaling pathway	TAS	--
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	TAS	--
GO:0006511	ubiquitin-dependent protein catabolic process	IC	9464850

No data available for SIGNOR curated interactions for PSMC6 Gene

Drugs & Compounds for PSMC6 Gene

(20) Drugs for PSMC6 Gene - From: DGIdb and Novoseek

Name	Status	Disease Links	Group	Role	Mechanism of Action	Clinical Trials
Bortezomib	Approved, Investigational	MalaCards Medline Plus	Pharma	inhibitor, other	Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors	888
carfilzomib	Approved, Investigational	MalaCards Medline Plus	Pharma	other, Inhibitor	Other, 20S Proteasome Inhibitor	0

(10) Additional Compounds for PSMC6 Gene - From: Novoseek

Name	Synonyms	Role	CAS Number	PubChem IDs	PubMed IDs

Drug Products

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Transcripts for PSMC6 Gene

mRNA/cDNA for PSMC6 Gene

2 REFSEQ mRNAs :

13 NCBI additional mRNA sequence :

18 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

ENST00000445930 2163 bps (ENST00000445930.7)
ENST00000458604 1093 bps (ENST00000458604.6)
ENST00000551328 650 bps (ENST00000551328.2)
ENST00000553798 563 bps (ENST00000553798.5)
ENST00000553899 706 bps (ENST00000553899.5)

CRISPR Products

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miRNA Products

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Inhibitory RNA Products

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Clone Products

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OriGene clones in human,mouse,rat for PSMC6
- SC205222
- MC210485
- RN200871
- SC118427
- SC320812
- SC327828
OriGene ORF clones in human,mouse,rat for PSMC6
- MG222069
- MR222069
- MR222069L3
- MR222069L4
- RC202809
- RC202809L1
- RC202809L2
- RC202809L3
- RC202809L4
- RC229193
- RC229193L1
- RC229193L3
- RG202809
- RG229193
- RR200871
- RR200871L3
- RR200871L4
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- RC202809L1V
- RC202809L2V
- RC202809L3V
- RC202809L4V
- RC229193L1V
- RC229193L3V
- RR200871L3V
- RR200871L4V
Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling

Sino Biological Human cDNA Clone for PSMC6

Search Addgene for plasmids for PSMC6

Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PSMC6

genomics-online: cdna clones - Search results for available PSMC6 gene related products
orf clones - Search results for available PSMC6 gene related products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMC6 Gene

No ASD Table

Relevant External Links for PSMC6 Gene

GeneLoc Exon Structure for: PSMC6

Expression for PSMC6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PSMC6 Gene

mRNA expression in normal human tissues for PSMC6 Gene

mRNA expression by BioGPS for PSMC6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Thymus (Hematopoietic System)
- Thymus

Protein differential expression in normal tissues from HIPED for PSMC6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMC6 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MaxQB, and MOPED for PSMC6 Gene

Integrated proteomics: cell line protein expression from ProteomicsDB, MOPED and MaxQB for PSMC6 Gene

Protein tissue co-expression partners for PSMC6 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PSMC6

SOURCE GeneReport for Unigene cluster for PSMC6 Gene:

Hs.156171

Evidence on tissue expression from TISSUES for PSMC6 Gene

Nervous system(4.8)
Liver(4.6)
Muscle(3.3)
Heart(3.1)
Kidney(2.8)
Lung(2.5)
Adrenal gland(2.4)
Blood(2.3)
Intestine(2.2)
Eye(2.1)
Skin(2)

Primer Products

OriGene qPCR primer pairs for PSMC6
- HP206431
- MP211860
OriGene qPCR primer pairs and template standards for PSMC6
- HK205967

genomics-online: primer clones - Search results for available PSMC6 gene related products

Gene Expression Assay Products

Applied Biosystems by Thermo Fisher Scientific TaqMan® Assays for PSMC6

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMC6 Gene

Orthologs for PSMC6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMC6 Gene

Organism	Taxonomy	Gene	Similarity	Type	Details
chimpanzee (Pan troglodytes)	Mammalia	PSMC6 ³¹ ³⁰	100 (n)	OneToOne	14:51655461-51677943 452909 XM_001159476.3 XP_001159476.1
oppossum (Monodelphis domestica)	Mammalia	PSMC6 ³¹	100 (a)	OneToOne	1:299198293-299235354
dog (Canis familiaris)	Mammalia	PSMC6 ³¹ ³⁰	96.44 (n)	OneToOne	32:35815133-35816317 478522 XM_535701.4 XP_535701.2
cow (Bos Taurus)	Mammalia	PSMC6 ³¹ ³⁰	95.46 (n)	OneToOne	10:11401913-11425951 518637 NM_001046240.2 NP_001039705.1
platypus (Ornithorhynchus anatinus)	Mammalia	PSMC6 ³¹	94 (a)	OneToOne	Contig8742:8282-21637
mouse (Mus musculus)	Mammalia	Psmc6 ¹⁷ ³¹ ³⁰	93.14 (n)		45329823 14:45329824-45349071 67089 NM_025959.3 NP_080235.2
rat (Rattus norvegicus)	Mammalia	Psmc6 ³⁰	92.89 (n)		289990 NM_001100509.1 NP_001093979.1
chicken (Gallus gallus)	Aves	PSMC6 ³¹ ³⁰	85.09 (n)	OneToOne	5:58108786-58120487 423586 NM_001006494.1 NP_001006494.1
lizard (Anolis carolinensis)	Reptilia	PSMC6 ³¹	99 (a)	OneToOne	GL343527.1:1977-19274
tropical clawed frog (Silurana tropicalis)	Amphibia	psmc6 ³⁰	83.2 (n)		394968 NM_204011.1 NP_989342.1
tropical clawed frog (Silurana tropicalis)	Amphibia	MGC76159 ³⁰			BC064227.1
African clawed frog (Xenopus laevis)	Amphibia	Xl.3381 ³⁰			BC045087.1
zebrafish (Danio rerio)	Actinopterygii	psmc6 ³¹ ³⁰	78.75 (n)	OneToOne	20:9944195-9957165 321585 NM_001003832.1 NP_001003832.1
zebrafish (Danio rerio)	Actinopterygii	Dr.29047 ³⁰			57039195
rainbow trout (Oncorhynchus mykiss)	Actinopterygii	Omy.8441 ³⁰			BX868329.1
fruit fly (Drosophila melanogaster)	Insecta	CG7257 ³²	81 (a)
		Rpt4R ³¹	80 (a)	OneToMany	3L:11935123-11936585
		Rpt4 ³¹ ³² ³⁰	70.22 (n)	OneToMany	X:6183503-6185276 31567 NM_132080.3 NP_572308.3
African malaria mosquito (Anopheles gambiae)	Insecta	AgaP_AGAP001407 ³⁰	69.44 (n)		1281769 XM_321726.5 XP_321726.5
worm (Caenorhabditis elegans)	Secernentea	rpt-4 ³¹ ³⁰	67.86 (n)	OneToOne	II:42207-46216 173384 NM_001026942.3 NP_001022113.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	RPT4 ³¹ ³⁰	64.4 (n)	OneToOne	XV:812395-813708 854433 NP_014902.3
K. lactis yeast (Kluyveromyces lactis)	Saccharomycetes	KLLA0C09592g ³⁰	62.23 (n)		2892259 XM_452625.1 XP_452625.1
A. gosspyii yeast (Ashbya gossypii)	Saccharomycetes	AGOS_AAL113W ³⁰	61.9 (n)		4618495 NM_207782.1 NP_982429.1
thale cress (Arabidopsis thaliana)	eudicotyledons	RPT4A ³⁰	69.55 (n)		834316 NM_123667.3 NP_199115.1
Alicante grape (Vitis vinifera)	eudicotyledons	Vvi.5748 ³⁰			CD719940.1
rice (Oryza sativa)	Liliopsida	Os02g0199900 ³⁰	68.74 (n)		4328642 NM_001052753.1 NP_001046218.1
rice (Oryza sativa)	Liliopsida	Os.292 ³⁰			AB033536.1
corn (Zea mays)	Liliopsida	Zm.3972 ³⁰			AY109445.1
wheat (Triticum aestivum)	Liliopsida	Ta.14349 ³⁰			CK161301.1
barley (Hordeum vulgare)	Liliopsida	Hv.5889 ³⁰			BJ464645.1
sea squirt (Ciona savignyi)	Ascidiacea	CSA.3434 ³¹	90 (a)	OneToOne	reftig_1:2804918-2810343
sea squirt (Ciona savignyi)	Ascidiacea	Cin.11771 ³⁰			AK117044.1
fission yeast (Schizosaccharomyces pombe)	Schizosaccharomycetes	rpt4 ³⁰	63.79 (n)		2539189 NP_587809.2
bread mold (Neurospora crassa)	Ascomycetes	NCU07367 ³⁰	61.84 (n)		3875020 XM_953767.2 XP_958860.2
sea squirt (Ciona intestinalis)	Ascidiacea	Cin.11771 ³⁰			AK117044.1

Species where no ortholog for PSMC6 was found in the sources mined by GeneCards:

Actinobacteria (Mycobacterium tuberculosis)
alpha proteobacteria (Wolbachia pipientis)
amoeba (Dictyostelium discoideum)
Archea (Pyrococcus horikoshii)
beta proteobacteria (Neisseria meningitidis)
Chromalveolata (Phytophthora infestans)
common water flea (Daphnia pulex)
E. coli (Escherichia coli)
filamentous fungi (Aspergillus nidulans)
Firmicute bacteria (Streptococcus pneumoniae)
green algae (Chlamydomonas reinhardtii)
honey bee (Apis mellifera)
loblloly pine (Pinus taeda)
malaria parasite (Plasmodium falciparum)
medicago trunc (Medicago Truncatula)
moss (Physcomitrella patens)
orangutan (Pongo pygmaeus)
pig (Sus scrofa)
rice blast fungus (Magnaporthe grisea)
schistosome parasite (Schistosoma mansoni)
sea anemone (Nematostella vectensis)
sea urchin (Strongylocentrotus purpuratus)
sorghum (Sorghum bicolor)
soybean (Glycine max)
stem rust fungus (Puccinia graminis)
sugarcane (Saccharum officinarum)
tomato (Lycopersicon esculentum)
toxoplasmosis (Toxoplasma gondii)
Trichoplax (Trichoplax adhaerens)

Evolution for PSMC6 Gene

ENSEMBL:: Gene Tree for PSMC6 (if available)
TreeFam:: Gene Tree for PSMC6 (if available)
Aminode:: Evolutionary constrained regions (ECRs) for PSMC6: view image

Paralogs for PSMC6 Gene

PSMC5 ⁵
PSMC2 ⁵
PSMC1 ⁵
PSMC3 ⁵
PSMC4 ⁵

(24) SIMAP similar genes for PSMC6 Gene using alignment to 9 proteins:

PRS10_HUMAN
H0YJC0_HUMAN
H0YJD2_HUMAN
H0YJE9_HUMAN
H0YJS8_HUMAN
H0YJT1_HUMAN
H0YJW2_HUMAN
H0YJX2_HUMAN
H0YJY8_HUMAN

Pseudogenes.org Pseudogenes for PSMC6 Gene

Variants for PSMC6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PSMC6 Gene

SNP ID	Clinical significance and condition	Chr 14 pos	Variation	AA Info	Type
717661	Likely Benign: not provided	52,707,216(+)	C/T		NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT

Additional dbSNP identifiers (rs#s) for PSMC6 Gene

Structural Variations from Database of Genomic Variants (DGV) for PSMC6 Gene

Variant ID	Type	Subtype	PubMed ID
esv2090227	CNV	deletion	18987734
nsv832796	CNV	loss	17160897
nsv983825	CNV	duplication	23825009

Variation tolerance for PSMC6 Gene

Residual Variation Intolerance Score: 25% of all genes are more intolerant (likely to be disease-causing)

Gene Damage Index Score: 0.38; 8.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PSMC6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for: PSMC6

SNP Genotyping and Copy Number Assay Products

Applied Biosystems by Thermo Fisher Scientific TaqMan® Assays for PSMC6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMC6 Gene

Disorders for PSMC6 Gene

(3) MalaCards diseases for PSMC6 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder	Aliases	PubMed IDs
cystic fibrosis	cf
pheochromocytoma	pcc	7953555
ehrlichiosis	human ehrlichiosis

- elite association - COSMIC cancer census association via MalaCards

Search PSMC6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PSMC6

: ATLAS of Genetics and Cytogenetics in Oncology and Haematology

Search disorders for PSMC6 gene in PubMed and other databases

No data available for UniProtKB/Swiss-Prot and Genatlas for PSMC6 Gene

Publications for PSMC6 Gene

Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases. (PMID: 9473509) Tanahashi N … Tanaka K (Biochemical and biophysical research communications 1998) ² ³ ²³ ⁵⁴
cDNA cloning of p42, a shared subunit of two proteasome regulatory proteins, reveals a novel member of the AAA protein family. (PMID: 8674546) Fujiwara T … DeMartino GN (FEBS letters 1996) ² ³ ⁴ ⁵⁴
An atomic structure of the human 26S proteasome. (PMID: 27428775) Huang X … Shi Y (Nature structural & molecular biology 2016) ³ ⁴ ⁵⁴
Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X … Huang L (Biochemistry 2007) ³ ⁴ ⁵⁴
Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases. (PMID: 15831487) Park Y … Yoon JB (Molecular and cellular biology 2005) ³ ⁴ ⁵⁴