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Aliases for PSMC6 Gene

Aliases for PSMC6 Gene

  • Proteasome 26S Subunit, ATPase 6 2 3 5
  • Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 6 2 3
  • 26S Proteasome AAA-ATPase Subunit RPT4 3 4
  • Proteasome Subunit P42 3 4
  • SUG2 3 4
  • 26S Proteasome Regulatory Subunit 10B 3
  • 26S Protease Regulatory Subunit S10B 3
  • 26S Protease Regulatory Subunit 10B 3
  • Conserved ATPase Domain Protein 44 3
  • Epididymis Secretory Protein Li 73 3
  • Proteasome 26S Subunit ATPase 6 4
  • HEL-S-73 3
  • CADP44 3
  • P44 3
  • P42 3

External Ids for PSMC6 Gene

Previous GeneCards Identifiers for PSMC6 Gene

  • GC14P050496
  • GC14P046969
  • GC14P051163
  • GC14P052243
  • GC14P053173
  • GC14P033334

Summaries for PSMC6 Gene

Entrez Gene Summary for PSMC6 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12. [provided by RefSeq, Jul 2008]

GeneCards Summary for PSMC6 Gene

PSMC6 (Proteasome 26S Subunit, ATPase 6) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and RET signaling. Gene Ontology (GO) annotations related to this gene include hydrolase activity and protein binding, bridging.

UniProtKB/Swiss-Prot for PSMC6 Gene

  • Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC6 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.

Gene Wiki entry for PSMC6 Gene

Additional gene information for PSMC6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMC6 Gene

Genomics for PSMC6 Gene

GeneHancer (GH) Regulatory Elements for PSMC6 Gene

Promoters and enhancers for PSMC6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J052706 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.2 161 2.4 HDGF PKNOX1 SMAD1 ARNT SIN3A DMAP1 ZNF48 YY1 ETS1 POLR2B PSMC6 STYX
GH14J051979 Enhancer 0.9 ENCODE dbSUPER 9.8 -727.9 -727885 0.2 CTCF RB1 RAD21 RFX5 ZNF791 SMC3 ZNF143 PRDM10 RCOR1 ZNF444 LOC105370500 FRMD6 PSMC6 TMX1 LOC105370497 ENSG00000259007 GNG2
GH14J051980 Enhancer 0.9 Ensembl dbSUPER 9.8 -728.1 -728062 0.2 CTCF RB1 RAD21 RFX5 ZNF791 ZNF143 PRDM10 RCOR1 ZNF444 BCLAF1 LOC105370500 FRMD6 PSMC6 TMX1 ENSG00000259007 LOC105370497 GNG2
GH14J052740 Enhancer 0.7 Ensembl ENCODE 11.3 +35.2 35159 3.4 PKNOX1 ELF1 MLLT1 RUNX3 SPI1 STYX PSMC6 ERO1A ENSG00000259049
GH14J053278 Enhancer 0.8 ENCODE 9.7 +572.2 572164 1.1 ELF3 ATF1 FOXA2 RARA ZNF766 FOS CAVIN1 ZBTB11 ZNF592 ZNF148 LOC101927620 LOC105370500 BMP4 ENSG00000237356 PSMC6 GC14M053236 PIR59222
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PSMC6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PSMC6 gene promoter:

Genomic Locations for PSMC6 Gene

Genomic Locations for PSMC6 Gene
chr14:52,707,163-52,728,587
(GRCh38/hg38)
Size:
21,425 bases
Orientation:
Plus strand
chr14:53,173,890-53,195,305
(GRCh37/hg19)

Genomic View for PSMC6 Gene

Genes around PSMC6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMC6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMC6 Gene

Proteins for PSMC6 Gene

  • Protein details for PSMC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62333-PRS10_HUMAN
    Recommended name:
    26S proteasome regulatory subunit 10B
    Protein Accession:
    P62333
    Secondary Accessions:
    • B2R975
    • P49719
    • Q6IBU3
    • Q92524

    Protein attributes for PSMC6 Gene

    Size:
    389 amino acids
    Molecular mass:
    44173 Da
    Quaternary structure:
    • Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC6 and few additional components (PubMed:27428775, PubMed:27342858). Interacts with PAAF1 (PubMed:15831487).

    Three dimensional structures from OCA and Proteopedia for PSMC6 Gene

neXtProt entry for PSMC6 Gene

Post-translational modifications for PSMC6 Gene

  • Ubiquitination at posLast=369369, Lys333, posLast=322322, Lys314, posLast=298298, posLast=274274, Lys197, posLast=180180, Lys168, posLast=4848, posLast=2020, and posLast=77
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PSMC6 Gene

Domains & Families for PSMC6 Gene

Gene Families for PSMC6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PSMC6 Gene

Suggested Antigen Peptide Sequences for PSMC6 Gene

Graphical View of Domain Structure for InterPro Entry

P62333

UniProtKB/Swiss-Prot:

PRS10_HUMAN :
  • Belongs to the AAA ATPase family.
Family:
  • Belongs to the AAA ATPase family.
genes like me logo Genes that share domains with PSMC6: view

Function for PSMC6 Gene

Molecular function for PSMC6 Gene

UniProtKB/Swiss-Prot Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC6 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
GENATLAS Biochemistry:
multicatalytic proteinase complex (prosome,macropain,26kDa) 19/22S regulator of proteasome p42,ATPase subunit,44kDa

Phenotypes From GWAS Catalog for PSMC6 Gene

Gene Ontology (GO) - Molecular Function for PSMC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0005524 ATP binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0016887 ATPase activity TAS 9464850
genes like me logo Genes that share ontologies with PSMC6: view
genes like me logo Genes that share phenotypes with PSMC6: view

Animal Model Products

CRISPR Products

miRNA for PSMC6 Gene

miRTarBase miRNAs that target PSMC6

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMC6

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMC6 Gene

Localization for PSMC6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMC6 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMC6 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 3
cytoskeleton 2
peroxisome 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PSMC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA,IEA 9464850
GO:0005634 nucleus IEA,IDA 10419517
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PSMC6: view

Pathways & Interactions for PSMC6 Gene

SuperPathways for PSMC6 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 Chks in Checkpoint Regulation
4 HIV Life Cycle
.45
5 Class I MHC mediated antigen processing and presentation
genes like me logo Genes that share pathways with PSMC6: view

Gene Ontology (GO) - Biological Process for PSMC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006511 ubiquitin-dependent protein catabolic process IC 9464850
genes like me logo Genes that share ontologies with PSMC6: view

No data available for SIGNOR curated interactions for PSMC6 Gene

Drugs & Compounds for PSMC6 Gene

(21) Drugs for PSMC6 Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 826
carfilzomib Approved, Investigational Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0

(9) Additional Compounds for PSMC6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PSMC6: view

Transcripts for PSMC6 Gene

mRNA/cDNA for PSMC6 Gene

Unigene Clusters for PSMC6 Gene

Proteasome (prosome, macropain) 26S subunit, ATPase, 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMC6

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMC6 Gene

No ASD Table

Relevant External Links for PSMC6 Gene

GeneLoc Exon Structure for
PSMC6
ECgene alternative splicing isoforms for
PSMC6

Expression for PSMC6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSMC6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PSMC6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMC6 Gene



Protein tissue co-expression partners for PSMC6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PSMC6 Gene:

PSMC6

SOURCE GeneReport for Unigene cluster for PSMC6 Gene:

Hs.156171

Evidence on tissue expression from TISSUES for PSMC6 Gene

  • Nervous system(4.8)
  • Liver(4.6)
  • Muscle(3.3)
  • Heart(3.1)
  • Kidney(2.8)
  • Lung(2.5)
  • Adrenal gland(2.4)
  • Blood(2.3)
  • Intestine(2.2)
  • Eye(2.1)
  • Skin(2)
genes like me logo Genes that share expression patterns with PSMC6: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMC6 Gene

Orthologs for PSMC6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMC6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMC6 34 33
  • 100 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PSMC6 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSMC6 34 33
  • 96.44 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PSMC6 34 33
  • 95.46 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSMC6 34
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Psmc6 16 34 33
  • 93.14 (n)
rat
(Rattus norvegicus)
Mammalia Psmc6 33
  • 92.89 (n)
chicken
(Gallus gallus)
Aves PSMC6 34 33
  • 85.09 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSMC6 34
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psmc6 33
  • 83.2 (n)
MGC76159 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.3381 33
zebrafish
(Danio rerio)
Actinopterygii psmc6 34 33
  • 78.75 (n)
OneToOne
Dr.29047 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8441 33
fruit fly
(Drosophila melanogaster)
Insecta CG7257 35
  • 81 (a)
Rpt4R 34
  • 80 (a)
OneToMany
Rpt4 34 35 33
  • 70.22 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001407 33
  • 69.44 (n)
worm
(Caenorhabditis elegans)
Secernentea rpt-4 34 33
  • 67.86 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPT4 34 33
  • 64.4 (n)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C09592g 33
  • 62.23 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL113W 33
  • 61.9 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons RPT4A 33
  • 69.55 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.5748 33
rice
(Oryza sativa)
Liliopsida Os02g0199900 33
  • 68.74 (n)
Os.292 33
barley
(Hordeum vulgare)
Liliopsida Hv.5889 33
corn
(Zea mays)
Liliopsida Zm.3972 33
wheat
(Triticum aestivum)
Liliopsida Ta.14349 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3434 34
  • 90 (a)
OneToOne
Cin.11771 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpt4 33
  • 63.79 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07367 33
  • 61.84 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11771 33
Species where no ortholog for PSMC6 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMC6 Gene

ENSEMBL:
Gene Tree for PSMC6 (if available)
TreeFam:
Gene Tree for PSMC6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PSMC6: view image

Paralogs for PSMC6 Gene

(24) SIMAP similar genes for PSMC6 Gene using alignment to 9 proteins:

  • PRS10_HUMAN
  • H0YJC0_HUMAN
  • H0YJD2_HUMAN
  • H0YJE9_HUMAN
  • H0YJS8_HUMAN
  • H0YJT1_HUMAN
  • H0YJW2_HUMAN
  • H0YJX2_HUMAN
  • H0YJY8_HUMAN

Pseudogenes.org Pseudogenes for PSMC6 Gene

genes like me logo Genes that share paralogs with PSMC6: view

No data available for Paralogs for PSMC6 Gene

Variants for PSMC6 Gene

Sequence variations from dbSNP and Humsavar for PSMC6 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000031124 -- 52,705,178(+) G/A upstream_transcript_variant
rs1000077396 -- 52,710,716(+) G/A 5_prime_UTR_variant, intron_variant
rs1000367724 -- 52,717,302(+) T/C intron_variant
rs1000402885 -- 52,725,205(+) G/C intron_variant
rs1000424289 -- 52,724,540(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PSMC6 Gene

Variant ID Type Subtype PubMed ID
esv2090227 CNV deletion 18987734
nsv832796 CNV loss 17160897
nsv983825 CNV duplication 23825009

Variation tolerance for PSMC6 Gene

Residual Variation Intolerance Score: 25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PSMC6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMC6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMC6 Gene

Disorders for PSMC6 Gene

Additional Disease Information for PSMC6

No disorders were found for PSMC6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMC6 Gene

Publications for PSMC6 Gene

  1. Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases. (PMID: 9473509) Tanahashi N … Tanaka K (Biochemical and biophysical research communications 1998) 2 3 22 58
  2. cDNA cloning of p42, a shared subunit of two proteasome regulatory proteins, reveals a novel member of the AAA protein family. (PMID: 8674546) Fujiwara T … DeMartino GN (FEBS letters 1996) 2 3 4 58
  3. Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X … Huang L (Biochemistry 2007) 3 4 58
  4. Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases. (PMID: 15831487) Park Y … Yoon JB (Molecular and cellular biology 2005) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for PSMC6 Gene

Sources for PSMC6 Gene

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