The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 n... See more...

Aliases for PSMC5 Gene

Aliases for PSMC5 Gene

  • Proteasome 26S Subunit, ATPase 5 2 3 5
  • P45/SUG 2 3 4
  • TRIP1 2 3 4
  • SUG1 2 3 4
  • Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 5 2 3
  • Thyroid Hormone Receptor-Interacting Protein 1 3 4
  • 26S Proteasome AAA-ATPase Subunit RPT6 3 4
  • 26S Proteasome Regulatory Subunit 8 3 4
  • Proteasome Subunit P45 3 4
  • SUG-1 2 3
  • TBP10 2 3
  • P45 2 3
  • S8 2 3
  • 26S Protease Regulatory Subunit 8 3
  • Testicular Tissue Protein Li 149 3
  • Proteasome 26S ATPase Subunit 5 3
  • Proteasome 26S Subunit ATPase 5 4
  • Tat-Binding Protein Homolog 10 3
  • Thyroid Receptor Interactor 1 3
  • MSUG1 Protein 3
  • PSMC5 5
  • RPT6 2

External Ids for PSMC5 Gene

Previous GeneCards Identifiers for PSMC5 Gene

  • GC17P061555
  • GC17P064331
  • GC17P062245
  • GC17P062378
  • GC17P059258
  • GC17P061904
  • GC17P057272

Summaries for PSMC5 Gene

Entrez Gene Summary for PSMC5 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for PSMC5 Gene

PSMC5 (Proteasome 26S Subunit, ATPase 5) is a Protein Coding gene. Diseases associated with PSMC5 include Mulibrey Nanism and Cockayne Syndrome. Among its related pathways are Downstream signaling events of B Cell Receptor (BCR) and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and transcription factor binding. An important paralog of this gene is PSMC1.

UniProtKB/Swiss-Prot Summary for PSMC5 Gene

  • Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.

Gene Wiki entry for PSMC5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSMC5 Gene

Genomics for PSMC5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PSMC5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSMC5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PSMC5

Top Transcription factor binding sites by QIAGEN in the PSMC5 gene promoter:
  • AML1a

Genomic Locations for PSMC5 Gene

Latest Assembly
chr17:63,827,152-63,832,026
(GRCh38/hg38)
Size:
4,875 bases
Orientation:
Plus strand

Previous Assembly
chr17:61,904,791-61,909,379
(GRCh37/hg19 by Entrez Gene)
Size:
4,589 bases
Orientation:
Plus strand

chr17:61,904,512-61,909,379
(GRCh37/hg19 by Ensembl)
Size:
4,868 bases
Orientation:
Plus strand

Genomic View for PSMC5 Gene

Genes around PSMC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMC5 Gene

Proteins for PSMC5 Gene

  • Protein details for PSMC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62195-PRS8_HUMAN
    Recommended name:
    26S proteasome regulatory subunit 8
    Protein Accession:
    P62195
    Secondary Accessions:
    • A8K3Z3
    • A8K763
    • O35051
    • O43208
    • P47210
    • P52915
    • P52916

    Protein attributes for PSMC5 Gene

    Size:
    406 amino acids
    Molecular mass:
    45626 Da
    Quaternary structure:
    • Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC5 and few additional components (PubMed:27428775, PubMed:27342858). Component of a complex with USP49 and RUVBL1 (PubMed:23824326). Interacts with PRPF19. Interacts with TRIM5 (PubMed:22078707). Interacts with NDC80 (PubMed:9295362, PubMed:10409732). Interacts with PAAF1 (PubMed:15831487). Interacts, in vitro, with the thyroid hormone receptor (in a thyroid hormone T3-dependent manner) and with retinoid X receptor (RXR) (By similarity). Interacts with ERCC6 (PubMed:26030138).

    Three dimensional structures from OCA and Proteopedia for PSMC5 Gene

    Alternative splice isoforms for PSMC5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMC5 Gene

Post-translational modifications for PSMC5 Gene

  • Ubiquitination at Lys15, Lys27, Lys38, Lys88, Lys94, Lys101, Lys125, Lys130, Lys142, Lys170, Lys196, Lys222, Lys330, and Lys397
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PSMC5 Gene

Domains & Families for PSMC5 Gene

Gene Families for PSMC5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PSMC5 Gene

InterPro:
Blocks:
  • Protein kinase PKN/PRK1, effector
ProtoNet:

Suggested Antigen Peptide Sequences for PSMC5 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ75514, highly similar to S.scrofa putative 26S protease subunit (A8K3Z3_HUMAN)
  • p45/SUG (PRS8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P62195

UniProtKB/Swiss-Prot:

PRS8_HUMAN :
  • Belongs to the AAA ATPase family.
Family:
  • Belongs to the AAA ATPase family.
genes like me logo Genes that share domains with PSMC5: view

Function for PSMC5 Gene

Molecular function for PSMC5 Gene

UniProtKB/Swiss-Prot Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
GENATLAS Biochemistry:
multicatalytic proteinase complex (proteasome,macropain,26S) 19/22S regulator of proteasome ,ATPase subunit,46kDa

Phenotypes From GWAS Catalog for PSMC5 Gene

Gene Ontology (GO) - Molecular Function for PSMC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005102 signaling receptor binding IEA --
GO:0005515 protein binding IPI 9173976
GO:0005524 ATP binding IEA --
GO:0008134 transcription factor binding IPI 9173976
genes like me logo Genes that share ontologies with PSMC5: view
genes like me logo Genes that share phenotypes with PSMC5: view

miRNA for PSMC5 Gene

Transcription Factor Targets for PSMC5 Gene

Selected GeneGlobe predicted Target genes for PSMC5

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMC5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and HOMER Transcription for PSMC5 Gene

Localization for PSMC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMC5 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMC5 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 4
plasma membrane 3
peroxisome 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PSMC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IEA,IDA 9464850
GO:0005634 nucleus IEA,IDA 9927201
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 9927201
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PSMC5: view

Pathways & Interactions for PSMC5 Gene

PathCards logo

SuperPathways for PSMC5 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 Chks in Checkpoint Regulation
.59
.59
.55
.43
.32
.31
4 HIV Life Cycle
.45
5 Pathways of neurodegeneration - multiple diseases
genes like me logo Genes that share pathways with PSMC5: view

Pathways by source for PSMC5 Gene

3 GeneGo (Thomson Reuters) pathways for PSMC5 Gene
  • Immune response Antigen presentation by MHC class I
  • Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
  • Transcription Ligand-Dependent Transcription of Retinoid-Target genes
19 Qiagen pathways for PSMC5 Gene
  • CDK5 Pathway
  • Chks in Checkpoint Regulation
  • DNA Repair Mechanisms
  • Estrogen-mediated S-Phase Entry
  • G2-M Phase Transition

Gene Ontology (GO) - Biological Process for PSMC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006357 regulation of transcription by RNA polymerase II IDA 7870181
genes like me logo Genes that share ontologies with PSMC5: view

No data available for SIGNOR curated interactions for PSMC5 Gene

Drugs & Compounds for PSMC5 Gene

(3) Drugs for PSMC5 Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 926
carfilzomib Approved, Investigational Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0

(2) Additional Compounds for PSMC5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PSMC5: view

Transcripts for PSMC5 Gene

mRNA/cDNA for PSMC5 Gene

2 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
21 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMC5

Alternative Splicing Database (ASD) splice patterns (SP) for PSMC5 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ·
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - - - - - - - - - - - - - -
SP7: -
SP8: - - -
SP9: - -
SP10: -
SP11: - -
SP12: -
SP13: -
SP14:

ExUns: 10c ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for PSMC5 Gene

GeneLoc Exon Structure for
PSMC5

Expression for PSMC5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PSMC5 Gene

Protein differential expression in normal tissues from HIPED for PSMC5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMC5 Gene



Protein tissue co-expression partners for PSMC5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PSMC5

SOURCE GeneReport for Unigene cluster for PSMC5 Gene:

Hs.79387

Evidence on tissue expression from TISSUES for PSMC5 Gene

  • Nervous system(4.9)
  • Liver(4.8)
  • Muscle(4.5)
  • Skin(3.5)
  • Lung(3.3)
  • Eye(2.7)
  • Kidney(2.6)
  • Intestine(2.5)
  • Thyroid gland(2.5)
  • Heart(2.4)
  • Lymph node(2.2)
  • Bone marrow(2.1)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with PSMC5: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMC5 Gene

Orthologs for PSMC5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMC5 Gene

Organism Taxonomy Gene Similarity Type Details
Oppossum
(Monodelphis domestica)
Mammalia PSMC5 31
  • 100 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia PSMC5 30 31
  • 99.75 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PSMC5 30 31
  • 91.87 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PSMC5 30 31
  • 91.79 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Psmc5 30 17 31
  • 90.23 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Psmc5 30
  • 90.15 (n)
Chicken
(Gallus gallus)
Aves PSMC5 30 31
  • 83 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PSMC5 31
  • 86 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia psmc5 30
  • 80.3 (n)
MGC75584 30
Zebrafish
(Danio rerio)
Actinopterygii psmc5 30 31
  • 81.69 (n)
OneToOne
wufa14g02 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8981 30
Fruit Fly
(Drosophila melanogaster)
Insecta Rpt6R 31
  • 87 (a)
OneToMany
CG2241 32
  • 87 (a)
Pros45 30 31 32
  • 77.78 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007243 30
  • 76.07 (n)
Worm
(Caenorhabditis elegans)
Secernentea F56F11.4 31
  • 74 (a)
OneToMany
rpt-6 30 31
  • 70.49 (n)
OneToMany
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AGL043C 30
  • 69.67 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPT6 30 31 33
  • 65.04 (n)
OneToOne
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A04752g 30
  • 64.61 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons RPT6A 30
  • 70.31 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6909 30
Soybean
(Glycine max)
eudicotyledons Gma.11232 30
Rice
(Oryza sativa)
Liliopsida Os02g0205300 30
  • 69.8 (n)
Os.317 30
Wheat
(Triticum aestivum)
Liliopsida Ta.27536 30
Corn
(Zea mays)
Liliopsida Zm.5322 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.5616 31
  • 97 (a)
OneToOne
Bread mold
(Neurospora crassa)
Ascomycetes NCU05363 30
  • 67.78 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpt6 30
  • 66.93 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.15364 30
Species where no ortholog for PSMC5 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMC5 Gene

ENSEMBL:
Gene Tree for PSMC5 (if available)
TreeFam:
Gene Tree for PSMC5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PSMC5: view image

Paralogs for PSMC5 Gene

Paralogs for PSMC5 Gene

(24) SIMAP similar genes for PSMC5 Gene using alignment to 9 proteins:

  • PRS8_HUMAN
  • J3KRP2_HUMAN
  • J3KTQ9_HUMAN
  • J3QLH6_HUMAN
  • J3QQM1_HUMAN
  • J3QRR3_HUMAN
  • J3QRW1_HUMAN
  • J3QSA9_HUMAN
  • J3QSE0_HUMAN

Pseudogenes.org Pseudogenes for PSMC5 Gene

genes like me logo Genes that share paralogs with PSMC5: view

Variants for PSMC5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PSMC5 Gene