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Aliases for PSMC5 Gene

Aliases for PSMC5 Gene

  • Proteasome 26S Subunit, ATPase 5 2 3 5
  • Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 5 2 3
  • Thyroid Hormone Receptor-Interacting Protein 1 3 4
  • 26S Proteasome AAA-ATPase Subunit RPT6 3 4
  • Proteasome Subunit P45 3 4
  • P45/SUG 3 4
  • TRIP1 3 4
  • SUG1 3 4
  • 26S Proteasome Regulatory Subunit 8 3
  • 26S Protease Regulatory Subunit 8 3
  • Testicular Tissue Protein Li 149 3
  • Proteasome 26S ATPase Subunit 5 3
  • Proteasome 26S Subunit ATPase 5 4
  • Tat-Binding Protein Homolog 10 3
  • Thyroid Receptor Interactor 1 3
  • MSUG1 Protein 3
  • SUG-1 3
  • TBP10 3
  • P45 3
  • S8 3

External Ids for PSMC5 Gene

Previous GeneCards Identifiers for PSMC5 Gene

  • GC17P061555
  • GC17P064331
  • GC17P062245
  • GC17P062378
  • GC17P059258
  • GC17P061904
  • GC17P057272

Summaries for PSMC5 Gene

Entrez Gene Summary for PSMC5 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for PSMC5 Gene

PSMC5 (Proteasome 26S Subunit, ATPase 5) is a Protein Coding gene. Diseases associated with PSMC5 include Mulibrey Nanism and Ogden Syndrome. Among its related pathways are Cell Cycle, Mitotic and RET signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and transcription factor binding.

UniProtKB/Swiss-Prot for PSMC5 Gene

  • Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.

Gene Wiki entry for PSMC5 Gene

Additional gene information for PSMC5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMC5 Gene

Genomics for PSMC5 Gene

GeneHancer (GH) Regulatory Elements for PSMC5 Gene

Promoters and enhancers for PSMC5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J063825 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 655.1 -0.1 -91 3.6 HDGF PKNOX1 CLOCK ARNT ARID4B NEUROD1 SIN3A DMAP1 ZNF2 YY1 FTSJ3 PSMC5 POLG2 CEP95 DDX42 SMARCD2 CSH2 DDX5 ENSG00000265982 ERN1
GH17J063694 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11 -127.9 -127881 10.2 HDGF PKNOX1 ARID4B SIN3A ZBTB7B IRF4 ZNF48 GLIS2 E2F8 ZNF207 STRADA LIMD2 GC17M063698 GC17M063699 PIR54058 LOC729683 FTSJ3 CSH2 ENSG00000125695 PSMC5
GH17J063837 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.8 +13.8 13819 7.4 CLOCK ZFP64 YBX1 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 SMARCD2 GC17P063839 FTSJ3 POLG2 CEP95 DDX42 ENSG00000265982 DDX5 PLEKHM1P1 SMURF2
GH17J063751 Enhancer 1 Ensembl ENCODE dbSUPER 11.6 -75.1 -75065 1 GATA3 ZNF512B MAX KLF4 ZNF384 MYC FOXA1 TCF7L2 ENSG00000125695 FTSJ3 PSMC5 STRADA CCDC47
GH17J063783 Enhancer 0.9 ENCODE dbSUPER 12 -41.0 -41010 4.3 SOX13 KLF1 SAP130 FOXA3 ARID4B RARA ZGPAT JUND PRDM6 MIER3 PIR56411 FTSJ3 PSMC5 ENSG00000125695 STRADA MAP3K3 CCDC47 DDX42
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSMC5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PSMC5 gene promoter:
  • AML1a

Genomic Locations for PSMC5 Gene

Genomic Locations for PSMC5 Gene
chr17:63,827,152-63,832,027
(GRCh38/hg38)
Size:
4,876 bases
Orientation:
Plus strand
chr17:61,904,512-61,909,387
(GRCh37/hg19)
Size:
4,876 bases
Orientation:
Plus strand

Genomic View for PSMC5 Gene

Genes around PSMC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMC5 Gene

Proteins for PSMC5 Gene

  • Protein details for PSMC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62195-PRS8_HUMAN
    Recommended name:
    26S proteasome regulatory subunit 8
    Protein Accession:
    P62195
    Secondary Accessions:
    • A8K3Z3
    • A8K763
    • O35051
    • O43208
    • P47210
    • P52915
    • P52916

    Protein attributes for PSMC5 Gene

    Size:
    406 amino acids
    Molecular mass:
    45626 Da
    Quaternary structure:
    • Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC5 and few additional components (PubMed:27428775, PubMed:27342858). Component of a complex with USP49 and RUVBL1 (PubMed:23824326). Interacts with PRPF19. Interacts with TRIM5 (PubMed:22078707). Interacts with NDC80 (PubMed:9295362, PubMed:10409732). Interacts with PAAF1 (PubMed:15831487). Interacts, in vitro, with the thyroid hormone receptor (in a thyroid hormone T3-dependent manner) and with retinoid X receptor (RXR).

    Three dimensional structures from OCA and Proteopedia for PSMC5 Gene

    Alternative splice isoforms for PSMC5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMC5 Gene

Post-translational modifications for PSMC5 Gene

  • Ubiquitination at posLast=397397, Lys330, Lys196, Lys170, posLast=142142, Lys130, posLast=125125, Lys101, Lys94, Lys88, Lys38, and Lys27
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PSMC5 Gene

Domains & Families for PSMC5 Gene

Gene Families for PSMC5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PSMC5 Gene

Graphical View of Domain Structure for InterPro Entry

P62195

UniProtKB/Swiss-Prot:

PRS8_HUMAN :
  • Belongs to the AAA ATPase family.
Family:
  • Belongs to the AAA ATPase family.
genes like me logo Genes that share domains with PSMC5: view

Function for PSMC5 Gene

Molecular function for PSMC5 Gene

UniProtKB/Swiss-Prot Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
GENATLAS Biochemistry:
multicatalytic proteinase complex (proteasome,macropain,26S) 19/22S regulator of proteasome ,ATPase subunit,46kDa

Phenotypes From GWAS Catalog for PSMC5 Gene

Gene Ontology (GO) - Molecular Function for PSMC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005102 signaling receptor binding IEA --
GO:0005515 protein binding IPI 9173976
GO:0005524 ATP binding IEA --
GO:0008134 transcription factor binding IPI 9173976
genes like me logo Genes that share ontologies with PSMC5: view
genes like me logo Genes that share phenotypes with PSMC5: view

Animal Model Products

miRNA for PSMC5 Gene

Transcription Factor Targets for PSMC5 Gene

Selected GeneGlobe predicted Target genes for PSMC5

Clone Products

  • Addgene plasmids for PSMC5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and HOMER Transcription for PSMC5 Gene

Localization for PSMC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMC5 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMC5 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 2
peroxisome 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PSMC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IEA,IDA 9464850
GO:0005634 nucleus IDA,IEA 9927201
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 9927201
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PSMC5: view

Pathways & Interactions for PSMC5 Gene

SuperPathways for PSMC5 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 Chks in Checkpoint Regulation
4 HIV Life Cycle
.45
5 Class I MHC mediated antigen processing and presentation
genes like me logo Genes that share pathways with PSMC5: view

Gene Ontology (GO) - Biological Process for PSMC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006357 regulation of transcription by RNA polymerase II IDA 7870181
genes like me logo Genes that share ontologies with PSMC5: view

No data available for SIGNOR curated interactions for PSMC5 Gene

Drugs & Compounds for PSMC5 Gene

(3) Drugs for PSMC5 Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 826
carfilzomib Approved, Investigational Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0

(2) Additional Compounds for PSMC5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PSMC5: view

Transcripts for PSMC5 Gene

Unigene Clusters for PSMC5 Gene

Proteasome (prosome, macropain) 26S subunit, ATPase, 5:
Representative Sequences:

Clone Products

  • Addgene plasmids for PSMC5

Alternative Splicing Database (ASD) splice patterns (SP) for PSMC5 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ·
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - - - - - - - - - - - - - -
SP7: -
SP8: - - -
SP9: - -
SP10: -
SP11: - -
SP12: -
SP13: -
SP14:

ExUns: 10c ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for PSMC5 Gene

GeneLoc Exon Structure for
PSMC5
ECgene alternative splicing isoforms for
PSMC5

Expression for PSMC5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSMC5 Gene

Protein differential expression in normal tissues from HIPED for PSMC5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMC5 Gene



Protein tissue co-expression partners for PSMC5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PSMC5 Gene:

PSMC5

SOURCE GeneReport for Unigene cluster for PSMC5 Gene:

Hs.79387

Evidence on tissue expression from TISSUES for PSMC5 Gene

  • Nervous system(4.9)
  • Liver(4.7)
  • Muscle(4.4)
  • Lung(3.3)
  • Skin(3.1)
  • Eye(2.4)
  • Thyroid gland(2.3)
genes like me logo Genes that share expression patterns with PSMC5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMC5 Gene

Orthologs for PSMC5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMC5 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia PSMC5 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PSMC5 34 33
  • 99.75 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PSMC5 34 33
  • 91.87 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PSMC5 34 33
  • 91.79 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Psmc5 16 34 33
  • 90.23 (n)
rat
(Rattus norvegicus)
Mammalia Psmc5 33
  • 90.15 (n)
chicken
(Gallus gallus)
Aves PSMC5 34 33
  • 83 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSMC5 34
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psmc5 33
  • 80.3 (n)
MGC75584 33
zebrafish
(Danio rerio)
Actinopterygii psmc5 34 33
  • 81.69 (n)
OneToOne
wufa14g02 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8981 33
fruit fly
(Drosophila melanogaster)
Insecta Rpt6R 34
  • 87 (a)
OneToMany
CG2241 35
  • 87 (a)
Pros45 34 35 33
  • 77.78 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007243 33
  • 76.07 (n)
worm
(Caenorhabditis elegans)
Secernentea F56F11.4 34
  • 74 (a)
OneToMany
rpt-6 34 33
  • 70.49 (n)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL043C 33
  • 69.67 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPT6 36 34 33
  • 65.04 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A04752g 33
  • 64.61 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons RPT6A 33
  • 70.31 (n)
soybean
(Glycine max)
eudicotyledons Gma.11232 33
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6909 33
rice
(Oryza sativa)
Liliopsida Os02g0205300 33
  • 69.8 (n)
Os.317 33
corn
(Zea mays)
Liliopsida Zm.5322 33
wheat
(Triticum aestivum)
Liliopsida Ta.27536 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5616 34
  • 97 (a)
OneToOne
Cin.15364 33
bread mold
(Neurospora crassa)
Ascomycetes NCU05363 33
  • 67.78 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpt6 33
  • 66.93 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15364 33
Species where no ortholog for PSMC5 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMC5 Gene

ENSEMBL:
Gene Tree for PSMC5 (if available)
TreeFam:
Gene Tree for PSMC5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PSMC5: view image

Paralogs for PSMC5 Gene

(24) SIMAP similar genes for PSMC5 Gene using alignment to 9 proteins:

  • PRS8_HUMAN
  • J3KRP2_HUMAN
  • J3KTQ9_HUMAN
  • J3QLH6_HUMAN
  • J3QQM1_HUMAN
  • J3QRR3_HUMAN
  • J3QRW1_HUMAN
  • J3QSA9_HUMAN
  • J3QSE0_HUMAN

Pseudogenes.org Pseudogenes for PSMC5 Gene

genes like me logo Genes that share paralogs with PSMC5: view

No data available for Paralogs for PSMC5 Gene

Variants for PSMC5 Gene

Sequence variations from dbSNP and Humsavar for PSMC5 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
VAR_035901 A colorectal cancer sample p.Arg60Gln
rs1000521662 -- 63,830,262(+) T/G intron_variant
rs1000576455 -- 63,828,367(+) T/C intron_variant
rs1000628655 -- 63,827,929(+) C/A/T intron_variant
rs1001589878 -- 63,827,193(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PSMC5 Gene

Variant ID Type Subtype PubMed ID
nsv510720 CNV deletion 20534489
nsv517272 CNV gain+loss 19592680
nsv833510 CNV loss 17160897

Variation tolerance for PSMC5 Gene

Residual Variation Intolerance Score: 21.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 5.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PSMC5 Gene

Human Gene Mutation Database (HGMD)
PSMC5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMC5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMC5 Gene

Disorders for PSMC5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PSMC5 Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
mulibrey nanism
  • muscle-liver-brain-eye nanism
ogden syndrome
  • ogdns
- elite association - COSMIC cancer census association via MalaCards
Search PSMC5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PSMC5

genes like me logo Genes that share disorders with PSMC5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSMC5 Gene

Publications for PSMC5 Gene

  1. Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases. (PMID: 9473509) Tanahashi N … Tanaka K (Biochemical and biophysical research communications 1998) 2 3 22 58
  2. Localization of genes encoding two human one-domain members of the AAA family: PSMC5 (the thyroid hormone receptor-interacting protein, TRIP1) and PSMC3 (the Tat-binding protein, TBP1). (PMID: 9048938) Hoyle J … Fisher EM (Human genetics 1997) 2 3 22 58
  3. USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing. (PMID: 23824326) Zhang Z … Wang H (Genes & development 2013) 3 4 58
  4. TRIM5α associates with proteasomal subunits in cells while in complex with HIV-1 virions. (PMID: 22078707) Lukic Z … Campbell EM (Retrovirology 2011) 3 4 58
  5. Interaction with Sug1 enables Ipaf ubiquitination leading to caspase 8 activation and cell death. (PMID: 20085538) Kumar Y … Swarup G (The Biochemical journal 2010) 3 22 58