The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 n... See more...

Aliases for PSMC4 Gene

Aliases for PSMC4 Gene

  • Proteasome 26S Subunit, ATPase 4 2 3 5
  • Tat-Binding Protein 7 2 3 4
  • TBP-7 2 3 4
  • TBP7 2 3 4
  • Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 4 2 3
  • 26S Proteasome AAA-ATPase Subunit RPT3 3 4
  • 26S Proteasome Regulatory Subunit 6B 3 4
  • MB67-Interacting Protein 3 4
  • Protease 26S Subunit 6 2 3
  • MIP224 3 4
  • RPT3 2 3
  • S6 2 3
  • 26S Protease Regulatory Subunit 6B 3
  • Proteasome 26S Subunit ATPase 4 4
  • MB67 Interacting Protein 2
  • MGC13687 2
  • MGC23214 2
  • MGC8570 2
  • PSMC4 5

External Ids for PSMC4 Gene

Previous HGNC Symbols for PSMC4 Gene

  • MIP224

Previous GeneCards Identifiers for PSMC4 Gene

  • GC19P041104
  • GC19P040868
  • GC19P045153
  • GC19P045168
  • GC19P040477
  • GC19P036913

Summaries for PSMC4 Gene

Entrez Gene Summary for PSMC4 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The encoded protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for PSMC4 Gene

PSMC4 (Proteasome 26S Subunit, ATPase 4) is a Protein Coding gene. Diseases associated with PSMC4 include Episodic Ataxia, Type 2 and Timothy Syndrome. Among its related pathways are Downstream signaling events of B Cell Receptor (BCR) and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include hydrolase activity and four-way junction helicase activity. An important paralog of this gene is PSMC1.

UniProtKB/Swiss-Prot Summary for PSMC4 Gene

  • Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.

Gene Wiki entry for PSMC4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSMC4 Gene

Genomics for PSMC4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PSMC4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSMC4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PSMC4

Top Transcription factor binding sites by QIAGEN in the PSMC4 gene promoter:
  • Elk-1
  • GATA-2
  • GATA-3
  • NF-1
  • p53
  • STAT5A

Genomic Locations for PSMC4 Gene

Latest Assembly
chr19:39,971,150-39,981,764
(GRCh38/hg38)
Size:
10,615 bases
Orientation:
Plus strand

Previous Assembly
chr19:40,477,072-40,487,671
(GRCh37/hg19 by Entrez Gene)
Size:
10,600 bases
Orientation:
Plus strand

chr19:40,476,912-40,487,348
(GRCh37/hg19 by Ensembl)
Size:
10,437 bases
Orientation:
Plus strand

Genomic View for PSMC4 Gene

Genes around PSMC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMC4 Gene

Proteins for PSMC4 Gene

  • Protein details for PSMC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43686-PRS6B_HUMAN
    Recommended name:
    26S proteasome regulatory subunit 6B
    Protein Accession:
    P43686
    Secondary Accessions:
    • Q96FV5
    • Q9UBM3
    • Q9UEX3

    Protein attributes for PSMC4 Gene

    Size:
    418 amino acids
    Molecular mass:
    47366 Da
    Quaternary structure:
    • Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC4 and few additional components (PubMed:27428775,PubMed:27342858). Interacts with NR1I3. Interacts with PAAF1 (PubMed:15831487). Interacts with TRIM5 (PubMed:22078707). Interacts with ZFAND1 (PubMed:29804830).

    Three dimensional structures from OCA and Proteopedia for PSMC4 Gene

    Alternative splice isoforms for PSMC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMC4 Gene

Post-translational modifications for PSMC4 Gene

  • Ubiquitination at Lys70, Lys125, Lys192, Lys217, Lys238, Lys255, and Lys273
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMC4 Gene

Antibodies for research

  • Abcam antibodies for PSMC4
  • Boster Bio Antibodies for PSMC4

No data available for DME Specific Peptides for PSMC4 Gene

Domains & Families for PSMC4 Gene

Gene Families for PSMC4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PSMC4 Gene

Suggested Antigen Peptide Sequences for PSMC4 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ93682, Homo sapiens proteasome (prosome, macropain) 26S subunit, ATPase, 4(PSMC4), transcript variant 1, mRNA (A8K2M0_HUMAN)
  • Tat-binding protein 7 (PRS6B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P43686

UniProtKB/Swiss-Prot:

PRS6B_HUMAN :
  • Belongs to the AAA ATPase family.
Family:
  • Belongs to the AAA ATPase family.
genes like me logo Genes that share domains with PSMC4: view

Function for PSMC4 Gene

Molecular function for PSMC4 Gene

UniProtKB/Swiss-Prot Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
GENATLAS Biochemistry:
multicatalytic proteinase complex (prosome,macropain,26S) 19/22S regulator of proteasome S6,ATPase subunit 4,51.6kDa

Phenotypes From GWAS Catalog for PSMC4 Gene

Gene Ontology (GO) - Molecular Function for PSMC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005515 protein binding IPI 12525503
GO:0005524 ATP binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0016887 ATPase activity TAS 9473509
genes like me logo Genes that share ontologies with PSMC4: view
genes like me logo Genes that share phenotypes with PSMC4: view

Animal Models for PSMC4 Gene

MGI Knock Outs for PSMC4:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMC4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PSMC4 Gene

Localization for PSMC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMC4 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMC4 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
lysosome 2
plasma membrane 1
extracellular 1
peroxisome 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PSMC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex TAS,IDA 17323924
GO:0005634 nucleus IEA,HDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PSMC4: view

Pathways & Interactions for PSMC4 Gene

PathCards logo

SuperPathways for PSMC4 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 Chks in Checkpoint Regulation
.59
.59
.55
.43
.32
.31
4 HIV Life Cycle
.45
5 Pathways of neurodegeneration - multiple diseases
genes like me logo Genes that share pathways with PSMC4: view

Pathways by source for PSMC4 Gene

3 GeneGo (Thomson Reuters) pathways for PSMC4 Gene
  • Immune response Antigen presentation by MHC class I
  • Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
  • Transcription Ligand-Dependent Transcription of Retinoid-Target genes
19 Qiagen pathways for PSMC4 Gene
  • CDK5 Pathway
  • Chks in Checkpoint Regulation
  • DNA Repair Mechanisms
  • Estrogen-mediated S-Phase Entry
  • G2-M Phase Transition

Gene Ontology (GO) - Biological Process for PSMC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006508 proteolysis TAS 8603043
genes like me logo Genes that share ontologies with PSMC4: view

No data available for SIGNOR curated interactions for PSMC4 Gene

Drugs & Compounds for PSMC4 Gene

(30) Drugs for PSMC4 Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 926
carfilzomib Approved, Investigational Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0

(10) Additional Compounds for PSMC4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PSMC4: view

Transcripts for PSMC4 Gene

mRNA/cDNA for PSMC4 Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR products for research