Aliases for PSMC3 Gene
Aliases for PSMC3 Gene
External Ids for PSMC3 Gene
- HGNC: 9549
- Entrez Gene: 5702
- Ensembl: ENSG00000165916
- OMIM: 186852
- UniProtKB: P17980
Previous GeneCards Identifiers for PSMC3 Gene
- GC11M049377
- GC11M048318
- GC11M047471
- GC11M047404
- GC11M047396
- GC11M047440
- GC11M047139
- GC11M047556
- GC11M047949
- GC11M050800
- GC11M051595
- GC11M052257
- GC11M052917
- GC11M053585
Summaries for PSMC3 Gene
-
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. [provided by RefSeq, Jul 2008]
GeneCards Summary for PSMC3 Gene
PSMC3 (Proteasome 26S Subunit, ATPase 3) is a Protein Coding gene. Among its related pathways are RET signaling and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include hydrolase activity and ATPase activity.
UniProtKB/Swiss-Prot for PSMC3 Gene
-
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
Additional gene information for PSMC3 Gene
- Monarch Initiative
- Search for PSMC3 at DataMed
- Search for PSMC3 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMC3 Gene
Genomics for PSMC3 Gene
GeneHancer (GH) Regulatory Elements for PSMC3 Gene
Promoters and enhancers for PSMC3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PSMC3 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PSMC3 gene promoter:
Regulatory Element Products
Genomic Locations for PSMC3 Gene
Genomic Locations for PSMC3 Gene
- chr11:47,418,769-47,426,473
- (GRCh38/hg38)
- Size:
- 7,705 bases
- Orientation:
- Minus strand
- chr11:47,440,320-47,448,024
- (GRCh37/hg19)
Genomic View for PSMC3 Gene
Genes around PSMC3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p11.2 by Ensembl
- 11p11.2 by Entrez Gene
- 11p11.2 by HGNC
PSMC3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PSMC3 Gene
Proteins for PSMC3 Gene
-
Protein details for PSMC3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P17980-PRS6A_HUMAN
- Recommended name:
- 26S proteasome regulatory subunit 6A
- Protein Accession:
- P17980
- B2R8V1
- Q3B757
- Q3B865
- Q53HU5
- Q6GPG8
- Q6IBS1
- Q96HD3
Protein attributes for PSMC3 Gene
- Size:
- 439 amino acids
- Molecular mass:
- 49204 Da
- Quaternary structure:
-
- Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC3 and few additional components (PubMed:27428775, PubMed:27342858). Interacts with PAAF1 (PubMed:15831487). Interacts with HIV-1 Tat (PubMed:2194290).
- SequenceCaution:
-
- Sequence=AAI07805.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for PSMC3 Gene
Post-translational modifications for PSMC3 Gene
- Sumoylated by UBE2I in response to MEKK1-mediated stimuli.
- Ubiquitination at isoforms=16, isoforms=35, isoforms=56, Lys70, Lys125, Lys146, isoforms=173, isoforms=211, isoforms=233, Lys245, Lys250, Lys266, Lys276, isoforms=278, Lys294, isoforms=300, isoforms=372, and Lys397
- Modification sites at PhosphoSitePlus
Other Protein References for PSMC3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for PSMC3
-
Abcam antibodies for PSMC3
-
Cloud-Clone Corp. Antibodies for PSMC3
- Invitrogen Antibodies for PSMC3
- GeneTex PSMC3 antibody for PSMC3
-
Santa Cruz Biotechnology (SCBT) Antibodies for PSMC3
Protein Products
-
OriGene Purified Proteins for PSMC3
- Search Origene for MassSpec and Protein Over-expression Lysates for PSMC3
- Origene Custom Protein Services for PSMC3
-
Cloud-Clone Corp. Proteins for PSMC3
- Search GeneTex for Proteins for PSMC3
-
Abcam proteins for PSMC3
Assay Products
No data available for DME Specific Peptides for PSMC3 Gene
Domains & Families for PSMC3 Gene
Gene Families for PSMC3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for PSMC3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PSMC3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P17980- Family:
-
- Belongs to the AAA ATPase family.
Function for PSMC3 Gene
Molecular function for PSMC3 Gene
- GENATLAS Biochemistry:
- multicatalytic proteinase complex (prosome,macropain,26S) 19/22S regulator of proteasome ,ATPase subunit,45kDa
- UniProtKB/Swiss-Prot Function:
- Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
Phenotypes From GWAS Catalog for PSMC3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 16763564 |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
| GO:0016887 | ATPase activity | ISS | 1429620 |
Phenotypes for PSMC3 Gene
- MGI mutant phenotypes for PSMC3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PSMC3:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased viability
- shRNA abundance <= 50%
- Decreased shRNA abundance (Z-score < -2)
- Dynamic nuclei (hole, folded or small irregular)
- Decreased NF-kappaB reporter expression
- FOXO1 nuclear localization
- Decreased viability with paclitaxel
- Increased shRNA abundance (Z-score > 2)
- Increased G1 DNA content
- G0/1 arrest
- Decreased shRNA abundance
- Negative genetic interaction between BLM-/- and BLM+/+
- Decreased viability of wild-type and TP53 knockout cells
- Increased Nanog expression
- Decreased HIV-1 infection
- HIV Rev nuclear localization
Animal Models for PSMC3 Gene
- MGI Knock Outs for PSMC3:
-
- Psmc3 tm1Aki
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PSMC3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for PSMC3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PSMC3 gene
- Search ViGene Biosciences for PSMC3
CRISPR Products
-
OriGene CRISPR knockouts for PSMC3
- genomics-online: gRNA clones - Search results for 144 available PSMC3 gene related products
- Overview of 144 available PSMC3 gene related products
- Applied Biological Materials CRISPR for PSMC3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSMC3
- GenScript: Design CRISPR guide RNA sequences for PSMC3
miRNA for PSMC3 Gene
- miRTarBase miRNAs that target PSMC3
miRNA Products
- Search ViGene Biosciences for PSMC3
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PSMC3
- Browse OriGene Inhibitory RNA Products For PSMC3
- genomics-online: shRNA clones - Search results for 144 available PSMC3 gene related products
- Overview of 144 available PSMC3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PSMC3 gene
Clone Products
- Sino Biological Human cDNA Clone for PSMC3
- VectorBuilder custom plasmid, inducible vectors for PSMC3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PSMC3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for PSMC3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for PSMC3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PSMC3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PSMC3 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PSMC3 Gene
Localization for PSMC3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PSMC3 Gene
- Cytoplasm. Nucleus. Note=Colocalizes with TRIM5 in the cytoplasmic bodies. {ECO:0000250 UniProtKB:O88685}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 4 |
| peroxisome | 2 |
- Cytosol (3)
- Nucleus (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000502 | proteasome complex | IDA,TAS | 17323924 |
| GO:0000932 | P-body | ISS | -- |
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005634 | nucleus | IDA,IEA | 2194290 |
| GO:0005654 | nucleoplasm | TAS | -- |
Pathways & Interactions for PSMC3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | CDK-mediated phosphorylation and removal of Cdc6 |
.93
.93
|
.80
.78
.78
.70
.47
.31
|
| 2 | RET signaling |
.92
|
.92
|
| 3 | Chks in Checkpoint Regulation | ||
| 4 | HIV Life Cycle |
.65
|
.45
|
| 5 | Class I MHC mediated antigen processing and presentation | ||
Pathways by source for PSMC3 Gene
1 Sino Biological pathway for PSMC3 Gene
2 BioSystems pathways for PSMC3 Gene
2 KEGG pathways for PSMC3 Gene
3 GeneGo (Thomson Reuters) pathways for PSMC3 Gene
19 Qiagen pathways for PSMC3 Gene
Interacting Proteins for PSMC3 Gene
Selected Interacting proteins:
P17980-PRS6A_HUMAN
ENSP00000298852
for PSMC3 Gene via
MINT
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0001824 | blastocyst development | IEA | -- |
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
| GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
No data available for SIGNOR curated interactions for PSMC3 Gene
Drugs & Compounds for PSMC3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Bortezomib | Approved, Investigational | Pharma | inhibitor, other | Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors | 826 | |
| carfilzomib | Approved, Investigational | Pharma | other, Inhibitor | Other, 20S Proteasome Inhibitor | 0 | |
| Phenethyl isothiocyanate | Investigational | Pharma | Target | 12 |
Transcripts for PSMC3 Gene
mRNA/cDNA for PSMC3 Gene
- (2) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (769) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PSMC3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for PSMC3
- genomics-online: gRNA clones - Search results for 144 available PSMC3 gene related products
- Overview of 144 available PSMC3 gene related products
- Applied Biological Materials CRISPR for PSMC3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSMC3
- GenScript: Design CRISPR guide RNA sequences for PSMC3
miRNA Products
- Search ViGene Biosciences for PSMC3
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PSMC3
- Browse OriGene Inhibitory RNA Products For PSMC3
- genomics-online: shRNA clones - Search results for 144 available PSMC3 gene related products
- Overview of 144 available PSMC3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PSMC3 gene
Clone Products
- Sino Biological Human cDNA Clone for PSMC3
- VectorBuilder custom plasmid, inducible vectors for PSMC3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PSMC3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for PSMC3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||
| SP4: |
Expression for PSMC3 Gene
This gene is overexpressed in Peripheral blood mononuclear cells (6.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSMC3 Gene
NURSA nuclear receptor signaling pathways regulating expression of PSMC3 Gene:
PSMC3SOURCE GeneReport for Unigene cluster for PSMC3 Gene:
Hs.250758Evidence on tissue expression from TISSUES for PSMC3 Gene
- Lung(4.8)
- Nervous system(4.8)
- Liver(4.6)
- Kidney(4.5)
- Skin(3.2)
- Intestine(2.6)
- Eye(2.4)
- Muscle(2.1)
Primer Products
-
OriGene qPCR primer pairs for PSMC3
- genomics-online: primer clones - Search results for 144 available PSMC3 gene related products
- Overview of 144 available PSMC3 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMC3 Gene
Orthologs for PSMC3 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PSMC3 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PSMC3 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | PSMC3 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | PSMC3 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Psmc3 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Psmc3 33 16 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | PSMC3 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PSMC3 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | PSMC3 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | psmc3 33 |
|
||
| Str.2886 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | psmc3-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | psmc3 33 34 |
|
||
| wufb39a02 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8620 33 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000616 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Tbp-1 35 33 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | rpt-5 33 34 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AER254W 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RPT5 33 34 36 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E21209g 33 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | RPT5B 33 |
|
||
| soybean (Glycine max) |
eudicotyledons | Gma.2136 33 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.1712 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os06g0173100 33 |
|
||
| Os.15233 33 |
|
||||
| barley (Hordeum vulgare) |
Liliopsida | Hv.3715 33 |
|
||
| wheat (Triticum aestivum) |
Liliopsida | Ta.22845 33 |
|
||
| corn (Zea mays) |
Liliopsida | Zm.6155 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne | |
| bread mold (Neurospora crassa) |
Ascomycetes | NCU04414 33 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rpt5 33 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.4352 33 |
|
- Species where no ortholog for PSMC3 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Paralogs for PSMC3 Gene
(20) SIMAP similar genes for PSMC3 Gene using alignment to 9 proteins:
Pseudogenes.org Pseudogenes for PSMC3 Gene
No data available for Paralogs for PSMC3 Gene
Variants for PSMC3 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000107979 | -- | 47,426,312(-) | G/A | 5_prime_UTR_variant | |
| rs1000567223 | -- | 47,421,798(-) | G/A | intron_variant | |
| rs1000907217 | -- | 47,426,471(-) | C/T | 5_prime_UTR_variant | |
| rs1000932226 | -- | 47,419,608(-) | C/T | intron_variant | |
| rs1000959229 | -- | 47,426,626(-) | G/C/T | upstream_transcript_variant |
Residual Variation Intolerance Score:
23.4% of all genes are more intolerant (likely to be disease-causing)