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The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. [provided by RefSeq, Jul 2008]
PSMC3 (Proteasome 26S Subunit, ATPase 3) is a Protein Coding gene. Diseases associated with PSMC3 include Type 1 Diabetes Mellitus 11 and Angelman Syndrome. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Antigen processing-Cross presentation. Gene Ontology (GO) annotations related to this gene include hydrolase activity and ATPase activity. An important paralog of this gene is PSMC1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0005515 | protein binding | IPI | 16763564 |
GO:0005524 | ATP binding | IEA | -- |
GO:0016787 | hydrolase activity | IEA | -- |
GO:0016887 | ATPase activity | ISS | 1429620 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000502 | proteasome complex | TAS,IDA | 17323924 |
GO:0000932 | P-body | IEA,ISS | -- |
GO:0005576 | extracellular region | TAS | -- |
GO:0005634 | nucleus | IDA | 2194290 |
GO:0005654 | nucleoplasm | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Regulation of activated PAK-2p34 by proteasome mediated degradation |
.93
.93
|
.80
.79
.78
.69
.47
|
2 | RET signaling |
.92
|
.92
|
3 | Chks in Checkpoint Regulation |
Chks in Checkpoint Regulation
.58
G2-M Phase Transition
.58
Estrogen-mediated S-Phase Entry
.54
|
SREBP Proteolysis
.42
DNA Repair Mechanisms
.31
Parkinson's Disease Pathway
.30
|
4 | HIV Life Cycle |
.65
|
.45
|
5 | Parkinson disease |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000165 | MAPK cascade | TAS | -- |
GO:0000209 | protein polyubiquitination | TAS | -- |
GO:0001824 | blastocyst development | IEA | -- |
GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Bortezomib | Approved, Investigational | Pharma | inhibitor, other | Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors | 910 | |
carfilzomib | Approved, Investigational | Pharma | other, Inhibitor | Other, 20S Proteasome Inhibitor | 0 | |
Phenethyl isothiocyanate | Investigational | Pharma | Target | 12 |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||
SP4: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PSMC3 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | PSMC3 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PSMC3 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PSMC3 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Psmc3 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Psmc3 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | PSMC3 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | PSMC3 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | PSMC3 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | psmc3 30 |
|
||
Str.2886 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | psmc3-prov 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | psmc3 30 31 |
|
OneToOne | |
wufb39a02 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8620 30 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000616 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Tbp-1 30 31 32 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | rpt-5 30 31 |
|
OneToOne | |
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AER254W 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RPT5 30 31 33 |
|
OneToOne | |
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E21209g 30 |
|
||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | RPT5B 30 |
|
||
Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.1712 30 |
|
||
Soybean (Glycine max) |
eudicotyledons | Gma.2136 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os06g0173100 30 |
|
||
Os.15233 30 |
|
||||
Barley (Hordeum vulgare) |
Liliopsida | Hv.3715 30 |
|
||
Wheat (Triticum aestivum) |
Liliopsida | Ta.22845 30 |
|
||
Corn (Zea mays) |
Liliopsida | Zm.6155 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne | |
Bread mold (Neurospora crassa) |
Ascomycetes | NCU04414 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rpt5 30 |
|
||
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.4352 30 |
|