The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 n... See more...

Aliases for PSMC3 Gene

Aliases for PSMC3 Gene

  • Proteasome 26S Subunit, ATPase 3 2 3 5
  • Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 3 2 3
  • 26S Proteasome AAA-ATPase Subunit RPT5 3 4
  • 26S Proteasome Regulatory Subunit 6A 3 4
  • Proteasome Subunit P50 3 4
  • Tat-Binding Protein 1 3 4
  • TBP1 3 4
  • Human Immunodeficiency Virus Tat Transactivator Binding Protein-1 3
  • 26S Protease Regulatory Subunit 6A 3
  • Testicular Secretory Protein Li 42 3
  • Proteasome 26S Subunit ATPase 3 4
  • TBP-1 4

External Ids for PSMC3 Gene

Previous GeneCards Identifiers for PSMC3 Gene

  • GC11M049377
  • GC11M048318
  • GC11M047471
  • GC11M047404
  • GC11M047396
  • GC11M047440
  • GC11M047139
  • GC11M047556
  • GC11M047949
  • GC11M055815
  • GC11M056040
  • GC11M056180
  • GC11M050800
  • GC11M051595
  • GC11M052257
  • GC11M052917
  • GC11M053585
  • GC11M054251
  • GC11M054917
  • GC11M055617

Summaries for PSMC3 Gene

Entrez Gene Summary for PSMC3 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. [provided by RefSeq, Jul 2008]

GeneCards Summary for PSMC3 Gene

PSMC3 (Proteasome 26S Subunit, ATPase 3) is a Protein Coding gene. Diseases associated with PSMC3 include Type 1 Diabetes Mellitus 11 and Type 1 Diabetes Mellitus 15. Among its related pathways are Metabolism of proteins and RET signaling. Gene Ontology (GO) annotations related to this gene include hydrolase activity and ATPase activity. An important paralog of this gene is PSMC1.

UniProtKB/Swiss-Prot Summary for PSMC3 Gene

  • Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.

Gene Wiki entry for PSMC3 Gene

Additional gene information for PSMC3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSMC3 Gene

Genomics for PSMC3 Gene

GeneHancer (GH) Regulatory Elements for PSMC3 Gene

Promoters and enhancers for PSMC3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSMC3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PSMC3

Top Transcription factor binding sites by QIAGEN in the PSMC3 gene promoter:
  • AML1a
  • c-Myb
  • Egr-1
  • HNF-4alpha1
  • HNF-4alpha2
  • Nkx2-5
  • RFX1
  • XBP-1
  • YY1

Genomic Locations for PSMC3 Gene

Genomic Locations for PSMC3 Gene
chr11:47,418,769-47,426,473
(GRCh38/hg38)
Size:
7,705 bases
Orientation:
Minus strand
chr11:47,440,320-47,448,024
(GRCh37/hg19)
Size:
7,705 bases
Orientation:
Minus strand

Genomic View for PSMC3 Gene

Genes around PSMC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMC3 Gene

Proteins for PSMC3 Gene

  • Protein details for PSMC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17980-PRS6A_HUMAN
    Recommended name:
    26S proteasome regulatory subunit 6A
    Protein Accession:
    P17980
    Secondary Accessions:
    • B2R8V1
    • Q3B757
    • Q3B865
    • Q53HU5
    • Q6GPG8
    • Q6IBS1
    • Q96HD3

    Protein attributes for PSMC3 Gene

    Size:
    439 amino acids
    Molecular mass:
    49204 Da
    Quaternary structure:
    • Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC3 and few additional components (PubMed:27428775, PubMed:27342858). Interacts with PAAF1 (PubMed:15831487).
    • (Microbial infection) Interacts with HIV-1 Tat.
    SequenceCaution:
    • Sequence=AAI07805.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PSMC3 Gene

neXtProt entry for PSMC3 Gene

Post-translational modifications for PSMC3 Gene

  • Sumoylated by UBE2I in response to MEKK1-mediated stimuli.
  • Ubiquitination at Lys16, Lys35, Lys53, Lys56, Lys70, Lys125, Lys146, Lys155, Lys173, Lys211, Lys233, Lys245, Lys250, Lys266, Lys276, Lys278, Lys294, Lys300, Lys372, and Lys397
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PSMC3 Gene

Domains & Families for PSMC3 Gene

Gene Families for PSMC3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PSMC3 Gene

Suggested Antigen Peptide Sequences for PSMC3 Gene

GenScript: Design optimal peptide antigens:
  • Tat-binding protein 1 (PRS6A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P17980

UniProtKB/Swiss-Prot:

PRS6A_HUMAN :
  • Belongs to the AAA ATPase family.
Family:
  • Belongs to the AAA ATPase family.
genes like me logo Genes that share domains with PSMC3: view

Function for PSMC3 Gene

Molecular function for PSMC3 Gene

UniProtKB/Swiss-Prot Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
GENATLAS Biochemistry:
multicatalytic proteinase complex (prosome,macropain,26S) 19/22S regulator of proteasome ,ATPase subunit,45kDa

Phenotypes From GWAS Catalog for PSMC3 Gene

Gene Ontology (GO) - Molecular Function for PSMC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005515 protein binding IPI 16763564
GO:0005524 ATP binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0016887 ATPase activity ISS 1429620
genes like me logo Genes that share ontologies with PSMC3: view
genes like me logo Genes that share phenotypes with PSMC3: view

Animal Models for PSMC3 Gene

MGI Knock Outs for PSMC3:

Animal Model Products

CRISPR Products

miRNA for PSMC3 Gene

miRTarBase miRNAs that target PSMC3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PSMC3 Gene

Localization for PSMC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMC3 Gene

Cytoplasm. Nucleus. Note=Colocalizes with TRIM5 in the cytoplasmic bodies. {ECO:0000250 UniProtKB:O88685}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMC3 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 4
peroxisome 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PSMC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex TAS,IDA 17323924
GO:0000932 P-body IEA,ISS --
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IDA 2194290
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with PSMC3: view

Pathways & Interactions for PSMC3 Gene

PathCards logo

SuperPathways for PSMC3 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 Chks in Checkpoint Regulation
.59
.59
.55
.43
.32
.31
4 HIV Life Cycle
.45
5 Class I MHC mediated antigen processing and presentation
genes like me logo Genes that share pathways with PSMC3: view

Pathways by source for PSMC3 Gene

2 KEGG pathways for PSMC3 Gene
3 GeneGo (Thomson Reuters) pathways for PSMC3 Gene
  • Immune response Antigen presentation by MHC class I
  • Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
  • Transcription Ligand-Dependent Transcription of Retinoid-Target genes
19 Qiagen pathways for PSMC3 Gene
  • CDK5 Pathway
  • Chks in Checkpoint Regulation
  • DNA Repair Mechanisms
  • Estrogen-mediated S-Phase Entry
  • G2-M Phase Transition

Gene Ontology (GO) - Biological Process for PSMC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0001824 blastocyst development IEA --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
genes like me logo Genes that share ontologies with PSMC3: view

No data available for SIGNOR curated interactions for PSMC3 Gene

Drugs & Compounds for PSMC3 Gene

(5) Drugs for PSMC3 Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 888
carfilzomib Approved, Investigational Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
Phenethyl isothiocyanate Investigational Pharma Target 14
genes like me logo Genes that share compounds with PSMC3: view

Transcripts for PSMC3 Gene

mRNA/cDNA for PSMC3 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMC3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2: -
SP3: -
SP4:

Relevant External Links for PSMC3 Gene

GeneLoc Exon Structure for
PSMC3

Expression for PSMC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PSMC3 Gene

Protein differential expression in normal tissues from HIPED for PSMC3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMC3 Gene



Protein tissue co-expression partners for PSMC3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PSMC3

SOURCE GeneReport for Unigene cluster for PSMC3 Gene:

Hs.250758

Evidence on tissue expression from TISSUES for PSMC3 Gene

  • Lung(4.8)
  • Nervous system(4.8)
  • Liver(4.6)
  • Kidney(4.5)
  • Skin(3.2)
  • Intestine(2.6)
  • Eye(2.4)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with PSMC3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMC3 Gene

Orthologs for PSMC3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMC3 31 30
  • 99.62 (n)
OneToOne