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The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 n... See more...
Aliases for PSMC3 Gene
Aliases for PSMC3 Gene
External Ids for PSMC3 Gene
- HGNC: 9549
- Entrez Gene: 5702
- Ensembl: ENSG00000165916
- OMIM: 186852
- UniProtKB: P17980
Previous GeneCards Identifiers for PSMC3 Gene
- GC11M049377
- GC11M048318
- GC11M047471
- GC11M047404
- GC11M047396
- GC11M047440
- GC11M047139
- GC11M047556
- GC11M047949
- GC11M055815
- GC11M056040
- GC11M056180
- GC11M059696
- GC11M050800
- GC11M051595
- GC11M052257
- GC11M052917
- GC11M053585
- GC11M054251
- GC11M054917
- GC11M055617
Summaries for PSMC3 Gene
-
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. [provided by RefSeq, Jul 2008]
GeneCards Summary for PSMC3 Gene
PSMC3 (Proteasome 26S Subunit, ATPase 3) is a Protein Coding gene. Diseases associated with PSMC3 include Type 1 Diabetes Mellitus 11 and Angelman Syndrome. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Antigen processing-Cross presentation. Gene Ontology (GO) annotations related to this gene include hydrolase activity and ATPase activity. An important paralog of this gene is PSMC1.
UniProtKB/Swiss-Prot Summary for PSMC3 Gene
-
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
Additional gene information for PSMC3 Gene
- HGNC(9549)
- Entrez Gene(5702)
- Ensembl(ENSG00000165916)
- OMIM(186852)
- UniProtKB(P17980)
- Open Targets Platform(ENSG00000165916)
- Monarch Initiative
- Search for PSMC3 at DataMed
- Search for PSMC3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSMC3 Gene
Genomics for PSMC3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PSMC3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PSMC3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PSMC3
- Top Transcription factor binding sites by QIAGEN in the PSMC3 gene promoter:
-
- AML1a
- c-Myb
- Egr-1
- HNF-4alpha1
- HNF-4alpha2
- Nkx2-5
- RFX1
- XBP-1
- YY1
Genomic Locations for PSMC3 Gene
Genomic Locations for PSMC3 Gene
- chr11:47,418,769-47,426,473
- (GRCh38/hg38)
- Size:
- 7,705 bases
- Orientation:
- Minus strand
- chr11:47,440,320-47,448,024
- (GRCh37/hg19)
- Size:
- 7,705 bases
- Orientation:
- Minus strand
Genomic View for PSMC3 Gene
Genes around PSMC3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p11.2 by HGNC
- 11p11.2 by Entrez Gene
- 11p11.2 by Ensembl
PSMC3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PSMC3 Gene
Proteins for PSMC3 Gene
-
Protein details for PSMC3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P17980-PRS6A_HUMAN
- Recommended name:
- 26S proteasome regulatory subunit 6A
- Protein Accession:
- P17980
- B2R8V1
- Q3B757
- Q3B865
- Q53HU5
- Q6GPG8
- Q6IBS1
- Q96HD3
Protein attributes for PSMC3 Gene
- Size:
- 439 amino acids
- Molecular mass:
- 49204 Da
- Quaternary structure:
-
- Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC3 and few additional components (PubMed:27428775, PubMed:27342858). Interacts with PAAF1 (PubMed:15831487).
- (Microbial infection) Interacts with HIV-1 Tat.
- SequenceCaution:
-
- Sequence=AAI07805.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Protein Expression for PSMC3 Gene
Post-translational modifications for PSMC3 Gene
- Sumoylated by UBE2I in response to MEKK1-mediated stimuli.
-
Ubiquitination at Lys16, Lys35, Lys53, Lys56, Lys70, Lys125, Lys146, Lys155, Lys173, Lys211, Lys233, Lys245, Lys250, Lys266, Lys276, Lys278, Lys294, Lys300, Lys372, and Lys397
- NX_P17980 (NX_P17980-1)
- Modification sites at PhosphoSitePlus
Other Protein References for PSMC3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ PSMC3 Antibody
- GeneTex Anti-PSMC3 antibody [N1C2] and Anti-PSMC3 antibody
-
Custom Antibody ServicesOriGene Antibodies for PSMC3
- AP42156PU-N
- CF500922
- CF500923
- CF500924
- CF500925
- CF500926
- CF500928
- CF500929
- CF500930
- CF500931
- CF500932
- CF500933
- CF809805
- TA308441
- TA332488
- TA500922
- TA500922S
- TA500923
- TA500923S
- TA500924
- TA500924S
- TA500925
- TA500925S
- TA500926
- TA500926S
- TA500928
- TA500928S
- TA500929
- TA500929S
- TA500930
- TA500930S
- TA500931
- TA500931S
- TA500932
- TA500932S
- TA500933
- TA500933S
- TA809805
- TA809805S
- Novus Biologicals Antibodies for PSMC3
- Invitrogen Antibodies for PSMC3 (AFLGC-PSMC3)
-
Boster Bio Antibodies for PSMC3
-
Santa Cruz Biotechnology (SCBT) Antibodies for PSMC3
- Sino Biological Antibodies for PSMC3
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for PSMC3
- Origene Custom Protein Services for PSMC3
-
Signalway Proteins for PSMC3
-
Abcam proteins for PSMC3
Assay Products
- antibodies-online: Show 2 available PSMC3 Elisa Kits ranked by validation data
- Compare Top PSMC3 Elisa Kits
-
Quality Products:
-
Boster Bio ELISA Kits for PSMC3
No data available for DME Specific Peptides for PSMC3 Gene
Domains & Families for PSMC3 Gene
Gene Families for PSMC3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for PSMC3 Gene
- InterPro:
- Blocks:
-
- AAA-protein subdomain
- ProtoNet:
Suggested Antigen Peptide Sequences for PSMC3 Gene
- GenScript: Design optimal peptide antigens:
-
- Tat-binding protein 1 (PRS6A_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P17980- Family:
-
- Belongs to the AAA ATPase family.
Function for PSMC3 Gene
Molecular function for PSMC3 Gene
- UniProtKB/Swiss-Prot Function:
- Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
- GENATLAS Biochemistry:
- multicatalytic proteinase complex (prosome,macropain,26S) 19/22S regulator of proteasome ,ATPase subunit,45kDa
Phenotypes From GWAS Catalog for PSMC3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 16763564 |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
| GO:0016887 | ATPase activity | ISS | 1429620 |
Phenotypes for PSMC3 Gene
- MGI mutant phenotypes for PSMC3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PSMC3:
-
- no effect
- Decreased viability
- Decreased vaccinia virus (VACV) infection
- Negative genetic interaction between BLM-/- and BLM+/+
- Decreased viability of wild-type and TP53 knockout cells
- Increased G1 DNA content
- Increased gamma-H2AX phosphorylation
- shRNA abundance <= 25%
- Reduced mammosphere formation
- Decreased shRNA abundance
- FOXO1 nuclear localization
- Inconclusive
- Increased Nanog expression
- HIV Rev nuclear localization
- Increased shRNA abundance (Z-score > 2)
- G0/1 arrest
- Decreased viability with paclitaxel
- Decreased viability (cell death)
- Decreased HIV-1 infection
Animal Models for PSMC3 Gene
- MGI Knock Outs for PSMC3:
-
- Psmc3 Psmc3<tm1Aki>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PSMC3 - Select products 50% OFF >
- * PSMC3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PSMC3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PSMC3
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSMC3
miRNA for PSMC3 Gene
- miRTarBase miRNAs that target PSMC3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PSMC3
- Browse OriGene Inhibitory RNA Products For PSMC3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMC3
Clone Products
- Applied Biological Materials (abm): Clones for PSMC3 - Select products 50% OFF >
- * PSMC3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PSMC3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PSMC3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PSMC3 Gene
Localization for PSMC3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PSMC3 Gene
- Cytoplasm. Nucleus. Note=Colocalizes with TRIM5 in the cytoplasmic bodies. {ECO:0000250 UniProtKB:O88685}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 4 |
| peroxisome | 2 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000502 | proteasome complex | TAS,IDA | 17323924 |
| GO:0000932 | P-body | IEA,ISS | -- |
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005634 | nucleus | IDA | 2194290 |
| GO:0005654 | nucleoplasm | TAS | -- |
Pathways & Interactions for PSMC3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of activated PAK-2p34 by proteasome mediated degradation |
.93
.93
|
.80
.79
.78
.69
.47
|
| 2 | RET signaling |
.92
|
.92
|
| 3 | Chks in Checkpoint Regulation |
Chks in Checkpoint Regulation
.58
G2-M Phase Transition
.58
Estrogen-mediated S-Phase Entry
.54
|
SREBP Proteolysis
.42
DNA Repair Mechanisms
.31
Parkinson's Disease Pathway
.30
|
| 4 | HIV Life Cycle |
.65
|
.45
|
| 5 | Parkinson disease | ||
Pathways by source for PSMC3 Gene
1 Sino Biological pathway for PSMC3 Gene
2 BioSystems pathways for PSMC3 Gene
6 KEGG pathways for PSMC3 Gene
3 GeneGo (Thomson Reuters) pathways for PSMC3 Gene
- Immune response Antigen presentation by MHC class I
- Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
- Transcription Ligand-Dependent Transcription of Retinoid-Target genes
19 Qiagen pathways for PSMC3 Gene
- CDK5 Pathway
- Chks in Checkpoint Regulation
- DNA Repair Mechanisms
- Estrogen-mediated S-Phase Entry
- G2-M Phase Transition
Interacting Proteins for PSMC3 Gene
Selected Interacting proteins:
P17980-PRS6A_HUMAN
ENSP00000481029
for PSMC3 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for PSMC3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0001824 | blastocyst development | IEA | -- |
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
| GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
No data available for SIGNOR curated interactions for PSMC3 Gene
Drugs & Compounds for PSMC3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Bortezomib | Approved, Investigational | Pharma | inhibitor, other | Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors | 910 | |
| carfilzomib | Approved, Investigational | Pharma | other, Inhibitor | Other, 20S Proteasome Inhibitor | 0 | |
| Phenethyl isothiocyanate | Investigational | Pharma | Target | 12 |
Transcripts for PSMC3 Gene
mRNA/cDNA for PSMC3 Gene
- 1 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000298852 1544 nts (view in UCSC)
- ENST00000524447 935 nts (view in UCSC)
- ENST00000526993 580 nts (view in UCSC)
- ENST00000527906 604 nts (view in UCSC)
- ENST00000528362 546 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PSMC3 - Select products 50% OFF >
- * PSMC3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PSMC3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PSMC3
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSMC3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PSMC3
- Browse OriGene Inhibitory RNA Products For PSMC3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMC3
Clone Products
- Applied Biological Materials (abm): Clones for PSMC3 - Select products 50% OFF >
- * PSMC3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PSMC3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PSMC3
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||
| SP4: |
Relevant External Links for PSMC3 Gene
- GeneLoc Exon Structure for
- PSMC3
Expression for PSMC3 Gene
This gene is overexpressed in Peripheral blood mononuclear cells (6.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMC3 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PSMC3
SOURCE GeneReport for Unigene cluster for PSMC3 Gene:
Hs.250758Evidence on tissue expression from TISSUES for PSMC3 Gene
- Nervous system(4.9)
- Lung(4.8)
- Liver(4.7)
- Kidney(4.6)
- Skin(3.6)
- Intestine(2.9)
- Muscle(2.7)
- Heart(2.4)
- Eye(2.4)
- Blood(2.1)
- Adrenal gland(2.1)
- Lymph node(2.1)
Primer Products
-
OriGene qPCR primer pairs for PSMC3
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMC3 Gene
Orthologs for PSMC3 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PSMC3 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | PSMC3 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PSMC3 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PSMC3 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Psmc3 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Psmc3 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | PSMC3 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | PSMC3 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | PSMC3 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | psmc3 30 |
|
||
| Str.2886 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | psmc3-prov 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | psmc3 30 31 |
|
OneToOne | |
| wufb39a02 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8620 30 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000616 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Tbp-1 30 31 32 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | rpt-5 30 31 |
|
OneToOne | |
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AER254W 30 |
|
||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RPT5 30 31 33 |
|
OneToOne | |
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E21209g 30 |
|
||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | RPT5B 30 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.1712 30 |
|
||
| Soybean (Glycine max) |
eudicotyledons | Gma.2136 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os06g0173100 30 |
|
||
| Os.15233 30 |
|
||||
| Barley (Hordeum vulgare) |
Liliopsida | Hv.3715 30 |
|
||
| Wheat (Triticum aestivum) |
Liliopsida | Ta.22845 30 |
|
||
| Corn (Zea mays) |
Liliopsida | Zm.6155 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne | |
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU04414 30 |
|
||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rpt5 30 |
|
||
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.4352 30 |
|
- Species where no ortholog for PSMC3 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Evolution for PSMC3 Gene
- ENSEMBL:
- Gene Tree for PSMC3 (if available)
- TreeFam:
- Gene Tree for PSMC3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PSMC3: view image
Paralogs for PSMC3 Gene
(20) SIMAP similar genes for PSMC3 Gene using alignment to 9 proteins:
- PRS6A_HUMAN
- E9PKD5_HUMAN
- E9PLG2_HUMAN
- E9PM69_HUMAN
- E9PMD8_HUMAN
- E9PMW0_HUMAN
- E9PN50_HUMAN
- E9PS45_HUMAN
- R4GNH3_HUMAN