PSMC3 Gene (Protein Coding)

Proteasome 26S Subunit, ATPase 3

GCID:: GC11M059696

GIFtS:: 43

Genes Participants

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 n... See more...

Aliases for PSMC3 Gene

Proteasome 26S Subunit, ATPase 3 ² ³ ⁵
Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 3 ² ³
26S Proteasome AAA-ATPase Subunit RPT5 ³ ⁴
26S Proteasome Regulatory Subunit 6A ³ ⁴
Proteasome Subunit P50 ³ ⁴
Tat-Binding Protein 1 ³ ⁴

TBP1 ³ ⁴
Human Immunodeficiency Virus Tat Transactivator Binding Protein-1 ³
26S Protease Regulatory Subunit 6A ³
Testicular Secretory Protein Li 42 ³
Proteasome 26S Subunit ATPase 3 ⁴
TBP-1 ⁴

External Ids for PSMC3 Gene

HGNC: 9549
Entrez Gene: 5702
Ensembl: ENSG00000165916
OMIM: 186852
UniProtKB: P17980

Previous GeneCards Identifiers for PSMC3 Gene

GC11M049377
GC11M048318
GC11M047471
GC11M047404
GC11M047396
GC11M047440
GC11M047139
GC11M047556
GC11M047949
GC11M055815
GC11M056040
GC11M056180
GC11M050800
GC11M051595
GC11M052257
GC11M052917
GC11M053585
GC11M054251
GC11M054917
GC11M055617

Search aliases for PSMC3 gene in PubMed and other databases

Summaries for PSMC3 Gene

Entrez Gene Summary for PSMC3 Gene

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. [provided by RefSeq, Jul 2008]

GeneCards Summary for PSMC3 Gene

PSMC3 (Proteasome 26S Subunit, ATPase 3) is a Protein Coding gene. Diseases associated with PSMC3 include Type 1 Diabetes Mellitus 11 and Type 1 Diabetes Mellitus 15. Among its related pathways are Metabolism of proteins and RET signaling. Gene Ontology (GO) annotations related to this gene include hydrolase activity and ATPase activity. An important paralog of this gene is PSMC1.

UniProtKB/Swiss-Prot Summary for PSMC3 Gene

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
- PRS6A_HUMAN,P17980

Gene Wiki entry for PSMC3 Gene

Additional gene information for PSMC3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSMC3 Gene

Genomics for PSMC3 Gene

GeneHancer (GH) Regulatory Elements for PSMC3 Gene

Promoters and enhancers for PSMC3 Gene

GeneHancer (GH) Identifier	GH Type	GH Score	GH Sources	Gene Association Score	Total Score	TSS distance (kb)	Number of Genes Away	Size (kb)	Transcription Factor Binding Sites
GH11J047424	Promoter/Enhancer	2.2	EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER	507.1	+0.3	282	3.7	ZBTB40 ZNF217 EP300 TCF12 NRF1 POLR2G SP1 NCOR1 PHF8 SIX5	PSMC3 lnc-RAPSN-1 C1QTNF4 MADD ARFGAP2 C11orf49 KBTBD4 FNBP4 ACP2 ENSG00000255197
GH11J047373	Promoter/Enhancer	2.1	EPDnew FANTOM5 Ensembl ENCODE dbSUPER	18.4	+49.8	49831	6.2	CTCF SIN3A NRF1 TCF12 NONO ZBTB5 ZIC2 POLR2A ZBTB10 ZNF263	SPI1 C1QTNF4 SLC39A13 PSMC3 ENSG00000200090 FNBP4 NUP160 ENSG00000255197 MDK MYBPC3
GH11J047399	Promoter/Enhancer	2.1	FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER	13	+25.7	25712	2.5	ZIC2 REST ZBTB10 ZBTB11 ZNF423 ZNF740 CTBP1 TRIM22 POLR2A ZEB1	MIR4487 SPI1 PSMC3 FNBP4 ENSG00000255197 MADD C11orf49 CELF1
GH11J047764	Promoter/Enhancer	2.7	EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER	6.7	-340.7	-340665	4.8	EP300 FOXK2 HNRNPK ZBTB40 TCF12 NRF1 MYC POLR2G USF1 SP1	FNBP4 lnc-FAM180B-4 lnc-FNBP4-1 NUP160 ENSG00000200090 C1QTNF4 DDB2 ENSG00000270060 PSMC3 PTPRJ
GH11J047406	Promoter/Enhancer	2.4	EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER	6.3	+17.5	17469	4.3	HNRNPK ZBTB40 ZNF217 EP300 CTCF SIN3A NRF1 TCF12 POLR2G GTF2E2	ENSG00000255197 SLC39A13 C1QTNF4 FNBP4 PSMC3

- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSMC3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PSMC3

Top Transcription factor binding sites by QIAGEN in the PSMC3 gene promoter:

AML1a
c-Myb
Egr-1
HNF-4alpha1
HNF-4alpha2
Nkx2-5
RFX1
XBP-1
YY1

Genomic Locations for PSMC3 Gene

chr11:47,418,769-47,426,473: (GRCh38/hg38)

Size:: 7,705 bases
Orientation:: Minus strand

chr11:47,440,320-47,448,024: (GRCh37/hg19)

Size:: 7,705 bases
Orientation:: Minus strand

Genomic View for PSMC3 Gene

Genes around PSMC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:

11p11.2 by HGNC
11p11.2 by Entrez Gene
11p11.2 by Ensembl

PSMC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

Genomic Location for PSMC3 Gene — Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PSMC3 Gene

NC_000011.10

Proteins for PSMC3 Gene

Protein details for PSMC3 Gene (UniProtKB/Swiss-Prot)
Protein Symbol:

P17980-PRS6A_HUMAN

Recommended name:

26S proteasome regulatory subunit 6A

Protein Accession:

P17980

Secondary Accessions:
- B2R8V1
- Q3B757
- Q3B865
- Q53HU5
- Q6GPG8
- Q6IBS1
- Q96HD3
Protein attributes for PSMC3 Gene
Size:

439 amino acids

Molecular mass:

49204 Da
Quaternary structure:
Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC3 and few additional components (PubMed:27428775, PubMed:27342858). Interacts with PAAF1 (PubMed:15831487).

(Microbial infection) Interacts with HIV-1 Tat.
SequenceCaution:
Sequence=AAI07805.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for PSMC3 Gene
- 5GJQ (3D)
- 5GJR (3D)
- 5L4G (3D)
- 5LN3 (3D)
- 5M32 (3D)
- 5T0C (3D)

neXtProt entry for PSMC3 Gene

Protein Expression for PSMC3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for PSMC3 Gene

Sumoylated by UBE2I in response to MEKK1-mediated stimuli.
- P17980-PRS6A_HUMAN
Ubiquitination at Lys16, Lys35, Lys53, Lys56, Lys70, Lys125, Lys146, Lys155, Lys173, Lys211, Lys233, Lys245, Lys250, Lys266, Lys276, Lys278, Lys294, Lys300, Lys372, and Lys397
- NX_P17980 (NX_P17980-1)
Modification sites at PhosphoSitePlus
- P17980

Other Protein References for PSMC3 Gene

ENSEMBL proteins:

REFSEQ proteins:

Antibody Products

G Biosciences Immunotag™ PSMC3 Antibody

Creative Diagnostics Anti-PSMC3 monoclonal antibody, clone 0H6

Creative Biolabs Recombinant Anti-Human PSMC3 Antibody and Mouse Anti-PSMC3 Recombinant Antibody (6E10)

OriGene Antibodies for PSMC3
- AP42156PU-N
- CF500922
- CF500923
- CF500924
- CF500925
- CF500926
- CF500928
- CF500929
- CF500930
- CF500931
- CF500932
- CF500933
- CF809805
- TA308441
- TA332488
- TA500922
- TA500922S
- TA500923
- TA500923S
- TA500924
- TA500924S
- TA500925
- TA500925S
- TA500926
- TA500926S
- TA500928
- TA500928S
- TA500929
- TA500929S
- TA500930
- TA500930S
- TA500931
- TA500931S
- TA500932
- TA500932S
- TA500933
- TA500933S
- TA809805
- TA809805S
Custom Antibody Services

Novus Biologicals Antibodies for PSMC3

Invitrogen Antibodies for PSMC3 (AFLGC-PSMC3)

antibodies-online: Show 64 available PSMC3 Antibodies ranked by validation data
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Recommended

Biorbyt antibodies for PSMC3

Boster Bio Antibodies for PSMC3
- M07208

Santa Cruz Biotechnology (SCBT) Antibodies for PSMC3
- PSMC3 (28-K)

Browse Sino Biological Antibodies

Protein Products

OriGene Purified Proteins for PSMC3
- NM_002804
- NM_002804
- NM_002804
- NM_002804
- NM_008948
Search Origene for MassSpec and Protein Over-expression Lysates for PSMC3
Origene Custom Protein Services for PSMC3

Novus Biologicals proteins and lysates for PSMC3

Browse ProSpec Recombinant Proteins

antibodies-online: Show 9 available PSMC3 Proteins ranked by validation data
Compare Top PSMC3 Proteins

Signalway Proteins for PSMC3
- AP79730

Search for PSMC3 Proteins at ProSci

Abcam proteins for PSMC3
- PSMC3

Assay Products

antibodies-online: Show 2 available PSMC3 Elisa Kits ranked by validation data
Compare Top PSMC3 Elisa Kits
Quality Products:
- ABIN6229207
- ABIN2685322

Boster Bio ELISA Kits for PSMC3
- EKC1486

Search for PSMC3 ELISA kits at Signalway

Browse Sino Biological Assays

No data available for DME Specific Peptides for PSMC3 Gene

Domains & Families for PSMC3 Gene

Gene Families for PSMC3 Gene

HGNC:

Human Protein Atlas (HPA):

Plasma proteins
Predicted intracellular proteins

Protein Domains for PSMC3 Gene

Blocks:

AAA-protein subdomain

InterPro:

ProtoNet:

P17980

Suggested Antigen Peptide Sequences for PSMC3 Gene

GenScript: Design optimal peptide antigens:

Tat-binding protein 1 (PRS6A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P17980

UniProtKB/Swiss-Prot:

PRS6A_HUMAN :

Belongs to the AAA ATPase family.

Family:

Belongs to the AAA ATPase family.

Function for PSMC3 Gene

Molecular function for PSMC3 Gene

UniProtKB/Swiss-Prot Function:

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.

PRS6A_HUMAN,P17980

GENATLAS Biochemistry:

multicatalytic proteinase complex (prosome,macropain,26S) 19/22S regulator of proteasome ,ATPase subunit,45kDa

PSMC3

Phenotypes From GWAS Catalog for PSMC3 Gene

Gene Ontology (GO) - Molecular Function for PSMC3 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005515	protein binding	IPI	16763564
GO:0005524	ATP binding	IEA	--
GO:0016787	hydrolase activity	IEA	--
GO:0016887	ATPase activity	ISS	1429620

Phenotypes for PSMC3 Gene

MGI mutant phenotypes for PSMC3:

inferred from 1 alleles

GenomeRNAi human phenotypes for PSMC3:

Animal Models for PSMC3 Gene

MGI Knock Outs for PSMC3:

Psmc3 ^{Psmc3<tm1Aki>}

Animal Model Products

Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study

CRISPR Products

Applied Biological Materials (abm): CRISPR Clones for PSMC3 - Select products 50% OFF >
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OriGene CRISPR knockouts for PSMC3
- GA103871
- GA203430
- KN401790
- KN514110

Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PSMC3

genomics-online: gRNA clones - Search for available PSMC3 gRNA products
Overview of 156 available PSMC3 gene related products
Recommended
- pCMV-SPORT6
- pCMV-SPORT6ccdB
- pOTB7
- pCR-BluntII-TOPO
- pDNR-LIB
- pGEM-T
- pUC19
- pDONR223

Santa Cruz Biotechnology (SCBT) CRISPR for PSMC3

miRNA for PSMC3 Gene

miRTarBase miRNAs that target PSMC3

miRNA Products

Search GeneCopoeia for miRNA 3'UTR Target clone products for PSMC3

Browse OriGene miRNA Products For PSMC3

Inhibitory RNA Products

Origene shrna, sirna, and RNAi products in human, mouse, rat for PSMC3
Browse OriGene Inhibitory RNA Products For PSMC3

Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMC3

genomics-online: shRNA clones - Search for available PSMC3 shRNA products
Overview of 156 available PSMC3 gene related products
Recommended
- pCMV-SPORT6
- pCMV-SPORT6ccdB
- pOTB7
- pCR-BluntII-TOPO
- pDNR-LIB
- pGEM-T
- pUC19
- pDONR223

Search Santa Cruz Biotechnology (SCBT) for PSMC3 siRNA/shRNA

Clone Products

Applied Biological Materials (abm): Clones for PSMC3 - Select products 50% OFF >
* PSMC3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
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OriGene clones in human,rat for PSMC3
- SC200669
- RN215250
- SC108209
- SC317718
OriGene ORF clones in human,mouse,rat for PSMC3
- MG207052
- MR207052
- MR207052L3
- MR207052L4
- RC201790
- RC201790L1
- RC201790L2
- RC201790L3
- RC201790L4
- RG201790
- RR215250
- RR215250L3
- RR215250L4
- MR207052L3V
- MR207052L4V
- RC201790L1V
- RC201790L2V
- RC201790L3V
- RC201790L4V
- RR215250L3V
- RR215250L4V
Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling

Sino Biological Human cDNA Clone for PSMC3

Search Addgene for plasmids for PSMC3

Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PSMC3

genomics-online: cdna clones - Search for available PSMC3 CDNA products
Overview of 156 available PSMC3 gene related products
Recommended
- pCMV-SPORT6
- pCMV-SPORT6ccdB
- pOTB7
- pCR-BluntII-TOPO
- pDNR-LIB
- pGEM-T
- pUC19
- pDONR223
orf clones - Search for available PSMC3 ORF products
Overview of 156 available PSMC3 gene related products
Recommended
- pCMV-SPORT6
- pCMV-SPORT6ccdB
- pOTB7
- pCR-BluntII-TOPO
- pDNR-LIB
- pGEM-T
- pUC19
- pDONR223

Cell Line Products

Browse ESI BIO Cell Lines and PureStem Progenitors for PSMC3

Browse GeneCopoeia Cell Lines

VectorBuilder Stable cell line generation for PSMC3

Search Horizon for Cell Lines for PSMC3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PSMC3 Gene

Localization for PSMC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMC3 Gene

Cytoplasm. Nucleus. Note=Colocalizes with TRIM5 in the cytoplasmic bodies. {ECO:0000250 UniProtKB:O88685}.

P17980-PRS6A_HUMAN

Subcellular locations from

COMPARTMENTS

Compartment	Confidence
nucleus	5
cytosol	5
extracellular	4
peroxisome	2
plasma membrane	1
cytoskeleton	1
mitochondrion	1
endoplasmic reticulum	1
lysosome	1
golgi apparatus	1

Subcellular locations from the

Human Protein Atlas (HPA)

Cytosol (3)
Nucleoplasm (3)

See all subcellular structures

Gene Ontology (GO) - Cellular Components for PSMC3 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000502	proteasome complex	TAS,IDA	17323924
GO:0000932	P-body	IEA,ISS	--
GO:0005576	extracellular region	TAS	--
GO:0005634	nucleus	IDA	2194290
GO:0005654	nucleoplasm	TAS	--

Pathways & Interactions for PSMC3 Gene

SuperPathways for PSMC3 Gene

	SuperPathway	Contained pathways
1	CDK-mediated phosphorylation and removal of Cdc6	Activation of APC/C and APC/C-Cdc20 mediated degradation of mitotic proteins .95 Cdc20-Phospho-APC/C mediated degradation of Cyclin A .95 Autodegradation of the E3 ubiquitin ligase COP1 .95 Stabilization of p53 .95 Regulation of activated PAK-2p34 by proteasome mediated degradation .94 Regulation of Apoptosis .94 CDK-mediated phosphorylation and removal of Cdc6 .94 Ubiquitin-dependent degradation of Cyclin D .94 Ubiquitin-dependent degradation of Cyclin D1 .94 Orc1 removal from chromatin .94 Regulation of DNA replication .94 Switching of origins to a post-replicative state .94 Cyclin A-Cdk2-associated events at S phase entry .93 Cyclin E associated events during G1/S transition .93 APC/C-Cdc20 mediated degradation of Securin .93 APC/C-Cdh1 mediated degradation of Cdc20 and other APC/C-Cdh1 targeted proteins in late mitosis/early G1 .93 APC/C-mediated degradation of cell cycle proteins .93 Regulation of APC/C activators between G1/S and early anaphase .93 Regulation of mitotic cell cycle .93 DNA Replication .93 Synthesis of DNA .93 Vpu mediated degradation of CD4 .93 Autodegradation of Cdh1 by Cdh1-APC/C .91 SCF-beta-TrCP mediated degradation of Emi1 .91 p53-Independent DNA Damage Response .91 p53-Independent G1/S DNA damage checkpoint .91 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A .91 ABC transporter disorders .91 Disorders of transmembrane transporters .91 Defective CFTR causes cystic fibrosis .90 Assembly of the pre-replicative complex .90 Hedgehog ligand biogenesis .90 Hh mutants abrogate ligand secretion .90 APC/C-Cdc20 mediated degradation of mitotic proteins .89 APC-Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint .89 Vif-mediated degradation of APOBEC3G .89 Degradation of GLI1 by the proteasome .89 Degradation of GLI2 by the proteasome .89 GLI3 is processed to GLI3R by the proteasome .89 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis .88	Degradation of AXIN .88 Cellular response to hypoxia .87 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha .87 Regulation of Hypoxia-inducible Factor (HIF) by oxygen .87 CDT1 association with the CDC6-ORC-origin complex .87 Hh mutants that dont undergo autocatalytic processing are degraded by ERAD .87 AUF1 (hnRNP D0) binds and destabilizes mRNA .86 p53-Dependent G1 DNA Damage Response .86 p53-Dependent G1/S DNA damage checkpoint .86 SCF(Skp2)-mediated degradation of p27/p21 .86 Removal of licensing factors from origins .86 NIK-->noncanonical NF-kB signaling .85 Dectin-1 mediated noncanonical NF-kB signaling .84 G1/S DNA Damage Checkpoints .84 Degradation of DVL .83 Cross-presentation of soluble exogenous antigens (endosomes) .82 The role of GTSE1 in G2/M progression after G2 checkpoint .81 Regulation of ornithine decarboxylase (ODC) .81 DNA Replication Pre-Initiation .80 M/G1 Transition .80 Proteasome .78 S Phase .78 Activation of NF-kappaB in B cells .77 Asymmetric localization of PCP proteins .74 FCERI mediated NF-kB activation .72 Regulation of RAS by GAPs .70 PCP/CE pathway .70 Beta-catenin independent WNT signaling .64 Degradation of beta-catenin by the destruction complex .64 Regulation of mRNA stability by proteins that bind AU-rich elements .63 Metabolism of polyamines .60 ABC-family proteins mediated transport .58 TNFR2 non-canonical NF-kB pathway .58 MAPK6/MAPK4 signaling .57 Proteasome Degradation .56 UCH proteinases .47 Canonical Wnt Pathway .32 Apoptosis .31 Programmed Cell Death .31
2	RET signaling	Frs2-mediated activation .95 GRB2 events in EGFR signaling .95 MAPK1/MAPK3 signaling .95 Prolonged ERK activation events .95 RAF/MAP kinase cascade .95 SHC1 events in EGFR signaling .95 Signaling by Leptin .95 SOS-mediated signalling .95 VEGFR2 mediated cell proliferation .95 ARMS-mediated activation .95 Signalling to ERKs .95 Signalling to p38 via RIT and RIN .95 Signalling to RAS .95 Interleukin receptor SHC signaling .95 Interleukin-3, 5 and GM-CSF signaling .94 Interleukin-2 signaling .94 Downstream signal transduction .94 Signaling by PDGF .94 DAP12 signaling .92	RET signaling .92 Insulin receptor signalling cascade .92 Signaling by Insulin receptor .92 IRS-mediated signalling .91 Signaling by EGFR .90 FCERI mediated MAPK activation .90 IGF1R signaling cascade .90 IRS-related events triggered by IGF1R .90 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) .90 DAP12 interactions .89 NCAM signaling for neurite out-growth .89 NGF signalling via TRKA from the plasma membrane .87 MAPK family signaling cascades .87 Signaling by SCF-KIT .85 Signalling by NGF .81 Fc epsilon receptor (FCERI) signaling .79 VEGFA-VEGFR2 Pathway .78 Signaling by VEGF .76 Gastrin-CREB signalling pathway via PKC and MAPK .55
3	Chks in Checkpoint Regulation	Chks in Checkpoint Regulation .59 G2-M Phase Transition .59 Estrogen-mediated S-Phase Entry .55	SREBP Proteolysis .43 DNA Repair Mechanisms .32 Parkinson's Disease Pathway .31
4	HIV Life Cycle	HIV Infection .64 Infectious disease .61 Host Interactions of HIV factors .57	Disease .45 Diseases of signal transduction .43
5	Class I MHC mediated antigen processing and presentation	Antigen processing- Ubiquitination and Proteasome degradation .83 Class I MHC mediated antigen processing and presentation .83	Adaptive Immune System .45

Pathways by source for PSMC3 Gene

1 Sino Biological pathway for PSMC3 Gene

Canonical Wnt Pathway

2 BioSystems pathways for PSMC3 Gene

165 Reactome pathways for PSMC3 Gene

2 KEGG pathways for PSMC3 Gene

3 GeneGo (Thomson Reuters) pathways for PSMC3 Gene

Immune response Antigen presentation by MHC class I
Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
Transcription Ligand-Dependent Transcription of Retinoid-Target genes

19 Qiagen pathways for PSMC3 Gene

CDK5 Pathway
Chks in Checkpoint Regulation
DNA Repair Mechanisms
Estrogen-mediated S-Phase Entry
G2-M Phase Transition

Interacting Proteins for PSMC3 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)

Selected Interacting proteins: P17980-PRS6A_HUMAN ENSP00000481029 for PSMC3 Gene via UniProtKB MINT STRING IID

Symbol	External ID(s)	Details
ABRAXAS2	Q15018 ²⁰ ¹²⁷ ENSP00000298492 ²¹	MINT-7230300 STRING: ENSP00000298492 IID: # exp=1
AMOTL2	Q9Y2J4 ⁴ ¹²⁷ Q9Y2J4-4 ⁴	EBI-359720, EBI-746752 EBI-359720, EBI-10187270 IID: # exp=2
CDC5L	Q99459 ²⁰ ¹²⁷ ENSP00000360532 ²¹	MINT-7947479 STRING: ENSP00000360532 IID: # exp=1
CDKN2A	ENSP00000418915 ²¹ P42771 ¹²⁷ Q8N726 ¹²⁷	STRING: ENSP00000418915 IID: # exp=2 IID: # exp=1
PSMC6	P62333 ⁴ ¹²⁷ ENSP00000401802 ²¹	EBI-359720, EBI-357669 STRING: ENSP00000401802 IID: # exp=8 # pred=5

GPS-Prot Interaction Network for PSMC3

;

Gene Ontology (GO) - Biological Process for PSMC3 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000165	MAPK cascade	TAS	--
GO:0000209	protein polyubiquitination	TAS	--
GO:0001824	blastocyst development	IEA	--
GO:0002223	stimulatory C-type lectin receptor signaling pathway	TAS	--
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	TAS	--

No data available for SIGNOR curated interactions for PSMC3 Gene

Drugs & Compounds for PSMC3 Gene

(5) Drugs for PSMC3 Gene - From: DrugBank, DGIdb, and Novoseek

Name	Status	Disease Links	Group	Role	Mechanism of Action	Clinical Trials
Bortezomib	Approved, Investigational	MalaCards Medline Plus	Pharma	inhibitor, other	Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors	888
carfilzomib	Approved, Investigational	MalaCards Medline Plus	Pharma	other, Inhibitor	Other, 20S Proteasome Inhibitor	0
Phenethyl isothiocyanate	Investigational	MalaCards Medline Plus	Pharma	Target		14

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Transcripts for PSMC3 Gene