Aliases for PSMC2 Gene
- Proteasome 26S Subunit, ATPase 2 2 3 5
- MSS1 2 3 4
- Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 2 2 3
- Mammalian Suppressor Of Sgv-1 Of Yeast 2 3
- 26S Proteasome AAA-ATPase Subunit RPT1 3 4
- Putative Protein Product Of Nbla10058 2 3
- 26S Proteasome Regulatory Subunit 7 3 4
- Protease 26S Subunit 7 2 3
External Ids for PSMC2 Gene
Previous GeneCards Identifiers for PSMC2 Gene
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2011]
GeneCards Summary for PSMC2 Gene
PSMC2 (Proteasome 26S Subunit, ATPase 2) is a Protein Coding gene. Diseases associated with PSMC2 include Alzheimer Disease and Cystic Fibrosis. Among its related pathways are Downstream signaling events of B Cell Receptor (BCR) and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include hydrolase activity and ATPase activity. An important paralog of this gene is PSMC5.
UniProtKB/Swiss-Prot Summary for PSMC2 Gene
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.