The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 n... See more...

Aliases for PSMC2 Gene

Aliases for PSMC2 Gene

  • Proteasome 26S Subunit, ATPase 2 2 3 5
  • MSS1 2 3 4
  • Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 2 2 3
  • Mammalian Suppressor Of Sgv-1 Of Yeast 2 3
  • 26S Proteasome AAA-ATPase Subunit RPT1 3 4
  • Putative Protein Product Of Nbla10058 2 3
  • 26S Proteasome Regulatory Subunit 7 3 4
  • Protease 26S Subunit 7 2 3
  • Nbla10058 2 3
  • S7 2 3
  • Testis Secretory Sperm-Binding Protein Li 197a 3
  • Proteasome 26S Subunit, ATPase, 2 2
  • 26S Protease Regulatory Subunit 7 3
  • Proteasome 26S Subunit ATPase 2 4
  • Protein MSS1 4
  • PSMC2 5
  • RPT1 2

External Ids for PSMC2 Gene

Previous GeneCards Identifiers for PSMC2 Gene

  • GC07P101472
  • GC07P102531
  • GC07P102548
  • GC07P102582
  • GC07P102775
  • GC07P102984
  • GC07P097351

Summaries for PSMC2 Gene

Entrez Gene Summary for PSMC2 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2011]

GeneCards Summary for PSMC2 Gene

PSMC2 (Proteasome 26S Subunit, ATPase 2) is a Protein Coding gene. Diseases associated with PSMC2 include Alzheimer Disease and Cystic Fibrosis. Among its related pathways are Downstream signaling events of B Cell Receptor (BCR) and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include hydrolase activity and ATPase activity. An important paralog of this gene is PSMC5.

UniProtKB/Swiss-Prot Summary for PSMC2 Gene

  • Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.

Gene Wiki entry for PSMC2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSMC2 Gene

Genomics for PSMC2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PSMC2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J103346 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 250.4 +19.9 19931 3.8 TBP CEBPA SIX5 NR2C1 MNT SMAD5 ETS1 MBD2 ZNF217 POLR2A RPS29P16 PSMC2 RPL23AP95 PMPCB CRYZP1 RPL7AP39 FAM185A DNAJC2 ORC5 NAPEPLD
GH07J103329 Enhancer 0.2 Ensembl 250.7 +1.1 1131 1 PSMC2 lnc-SLC26A5-1 DNAJC2 PMPCB
GH07J103343 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 0.4 +15.6 15631 2.8 CHD2 TBP BCL11A SP1 MXD4 CEBPA SIX5 NR2C1 MNT IKZF1 DNAJC2 RPL7AP39 CRYZP1 PMPCB ORC5 PRKRIP1 ENSG00000239486 POLR2J3 SLC26A5 POLR2J2
GH07J103296 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 0.3 -30.5 -30497 2.7 CHD2 TBP MXD4 CEBPA NR2C1 MNT DEK SMAD5 ETS1 IRF2 NONHSAG048449.2 lnc-DNAJC2-1 RF00017-6533 PMPCB NAPEPLD ARMC10 RASA4 PSMC2
GH07J103347 Promoter 0.6 Ensembl 0.4 +17.7 17731 0.2 PRDM6 HDAC2 KDM1A SMARCA5 DNAJC2 RPS29P16 PSMC2 SLC26A5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSMC2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PSMC2

Top Transcription factor binding sites by QIAGEN in the PSMC2 gene promoter:
  • AREB6
  • Bach1
  • Egr-2
  • Evi-1
  • Max1
  • Pax-5
  • PPAR-gamma1
  • PPAR-gamma2
  • SRF
  • SRF (504 AA)

Genomic Locations for PSMC2 Gene

Latest Assembly
chr7:103,328,570-103,370,346
(GRCh38/hg38)
Size:
41,777 bases
Orientation:
Plus strand

Previous Assembly
chr7:102,987,971-103,009,842
(GRCh37/hg19 by Entrez Gene)
Size:
21,872 bases
Orientation:
Plus strand

chr7:102,984,701-103,009,842
(GRCh37/hg19 by Ensembl)
Size:
25,142 bases
Orientation:
Plus strand

Genomic View for PSMC2 Gene

Genes around PSMC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMC2 Gene

Proteins for PSMC2 Gene

  • Protein details for PSMC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35998-PRS7_HUMAN
    Recommended name:
    26S proteasome regulatory subunit 7
    Protein Accession:
    P35998
    Secondary Accessions:
    • A4D0Q1
    • B7Z5E2
    • Q3LIA5
    • Q9UDI3

    Protein attributes for PSMC2 Gene

    Size:
    433 amino acids
    Molecular mass:
    48634 Da
    Quaternary structure:
    • Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC2 and few additional components (PubMed:27428775, PubMed:27342858). Interacts with NDC80/HEC; this interaction is detected only during M phase. Interacts and SQSTM1 (PubMed:15340068). Interacts with PAAF1 (PubMed:15831487). Directly interacts with TRIM5 (PubMed:22078707).

    Three dimensional structures from OCA and Proteopedia for PSMC2 Gene

    Alternative splice isoforms for PSMC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMC2 Gene

Post-translational modifications for PSMC2 Gene

  • Ubiquitination at Lys146, Lys34, Lys181, Lys46, Lys57, Lys210, Lys84, Lys222, Lys100, Lys110, Lys248, Lys116, Lys120, Lys267, Lys268, Lys340, Lys402, Lys407, Lys415, and Lys422
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PSMC2 Gene

Domains & Families for PSMC2 Gene

Gene Families for PSMC2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PSMC2 Gene

Suggested Antigen Peptide Sequences for PSMC2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ52353, highly similar to 26S protease regulatory subunit 7 (B7Z5E2_HUMAN)
  • Protein MSS1 (PRS7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P35998

UniProtKB/Swiss-Prot:

PRS7_HUMAN :
  • Belongs to the AAA ATPase family.
Family:
  • Belongs to the AAA ATPase family.
genes like me logo Genes that share domains with PSMC2: view

Function for PSMC2 Gene

Molecular function for PSMC2 Gene

UniProtKB/Swiss-Prot Function:
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
UniProtKB/Swiss-Prot Induction:
Expression is not cell cycle-dependent and occurs throughout the cell cycle.
GENATLAS Biochemistry:
multicatalytic proteinase complex (prosome,macropain,26S) 19/22S regulator of proteasome S7,ATPase subunit 2,48.6kDa

Phenotypes From GWAS Catalog for PSMC2 Gene

Gene Ontology (GO) - Molecular Function for PSMC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0005524 ATP binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0016887 ATPase activity IDA 9295362
genes like me logo Genes that share ontologies with PSMC2: view
genes like me logo Genes that share phenotypes with PSMC2: view

Animal Models for PSMC2 Gene

MGI Knock Outs for PSMC2:
  • Psmc2 Psmc2<tm1b(EUCOMM)Hmgu>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMC2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PSMC2 Gene

Localization for PSMC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMC2 Gene

Cytoplasm. Note=Colocalizes with TRIM5 in cytoplasmic bodies. {ECO:0000269 PubMed:22078707}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMC2 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 4
peroxisome 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytoplasmic bodies (3)
  • Cytosol (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PSMC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IEA,IDA 9295362
GO:0000932 P-body ISS --
GO:0005576 extracellular region TAS --
GO:0005634 nucleus HDA 21630459
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with PSMC2: view

Pathways & Interactions for PSMC2 Gene

PathCards logo

SuperPathways for PSMC2 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 Chks in Checkpoint Regulation
.59
.59
.55
.43
.32
.31
4 HIV Life Cycle
.45
5 Pathways of neurodegeneration - multiple diseases
genes like me logo Genes that share pathways with PSMC2: view

Pathways by source for PSMC2 Gene

3 GeneGo (Thomson Reuters) pathways for PSMC2 Gene
  • Immune response Antigen presentation by MHC class I
  • Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
  • Transcription Ligand-Dependent Transcription of Retinoid-Target genes
19 Qiagen pathways for PSMC2 Gene
  • CDK5 Pathway
  • Chks in Checkpoint Regulation
  • DNA Repair Mechanisms
  • Estrogen-mediated S-Phase Entry
  • G2-M Phase Transition

Gene Ontology (GO) - Biological Process for PSMC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0001649 osteoblast differentiation HDA 16210410
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
genes like me logo Genes that share ontologies with PSMC2: view

No data available for SIGNOR curated interactions for PSMC2 Gene

Drugs & Compounds for PSMC2 Gene

(4) Drugs for PSMC2 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 926
carfilzomib Approved, Investigational Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
MLN9708 Pharma Inhibitor Proteasome inhibitor, 20S Proteasome Inhibitor 0
Salinosporamide A Pharma Inhibitor 20S Catalytic Core subunit of the Proteasome Inhibitor 0
genes like me logo Genes that share compounds with PSMC2: view

Transcripts for PSMC2 Gene

mRNA/cDNA for PSMC2 Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMC2

Alternative Splicing Database (ASD) splice patterns (SP) for PSMC2 Gene

No ASD Table

Relevant External Links for PSMC2 Gene

GeneLoc Exon Structure for
PSMC2

Expression for PSMC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PSMC2 Gene

Protein differential expression in normal tissues from HIPED for PSMC2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMC2 Gene



Protein tissue co-expression partners for PSMC2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PSMC2

SOURCE GeneReport for Unigene cluster for PSMC2 Gene:

Hs.437366

Evidence on tissue expression from TISSUES for PSMC2 Gene

  • Nervous system(4.9)
  • Liver(4.7)
  • Blood(4.5)
  • Skin(3.9)
  • Lung(3.5)
  • Pancreas(3.1)
  • Kidney(2.7)
  • Eye(2.6)
  • Muscle(2.4)
  • Bone marrow(2.2)
genes like me logo Genes that share expression patterns with PSMC2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMC2 Gene

Orthologs for PSMC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMC2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PSMC2 30 31
  • 99.62 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PSMC2 31
  • 95 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia PSMC2 30 31
  • 94.15 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PSMC2 30 31
  • 92.76 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Psmc2 30
  • 89.38 (n)
Mouse
(Mus musculus)
Mammalia Psmc2 30 17 31
  • 88.84 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PSMC2 31
  • 80 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PSMC2 30 31
  • 85.3 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PSMC2 31
  • 100 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia psmc2 30
  • 81.83 (n)
MGC76296 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.6003 30
Zebrafish
(Danio rerio)
Actinopterygii psmc2 30 31
  • 79.68 (n)
OneToOne
zgc63995 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8644 30
Fruit Fly
(Drosophila melanogaster)
Insecta Rpt1 30 31 32
  • 73.75 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011174 30
  • 72.75 (n)
Worm
(Caenorhabditis elegans)
Secernentea rpt-1 30 31
  • 72.75 (n)
OneToOne
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E13773g 30
  • 69.13 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPT1 30 31 33
  • 68.43 (n)
OneToOne
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ACR050C 30
  • 67.53 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons RPT1A 30
  • 70 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7468 30
Soybean
(Glycine max)
eudicotyledons Gma.5808 30
Rice
(Oryza sativa)
Liliopsida Os06g0192600 30
  • 71.1 (n)
Os.291 30
Barley
(Hordeum vulgare)
Liliopsida Hv.3383 30
Wheat
(Triticum aestivum)
Liliopsida Ta.3887 30
Corn
(Zea mays)
Liliopsida Zm.5401 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.6445 31
  • 91 (a)
OneToOne
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpt1 30
  • 66.98 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU02840 30
  • 65.51 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.8956 30
Species where no ortholog for PSMC2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMC2 Gene

ENSEMBL:
Gene Tree for PSMC2 (if available)
TreeFam:
Gene Tree for PSMC2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PSMC2: view image

Paralogs for PSMC2 Gene

Paralogs for PSMC2 Gene

(21) SIMAP similar genes for PSMC2 Gene using alignment to 4 proteins:

  • PRS7_HUMAN
  • B7Z5E2_HUMAN
  • C9JLS9_HUMAN
  • Q75L23_HUMAN

Pseudogenes.org Pseudogenes for PSMC2 Gene

genes like me logo Genes that share paralogs with PSMC2: view

Variants for PSMC2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PSMC2 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
992332 Uncertain Significance: not provided 103,364,302(+) G/T
NM_002803.4(PSMC2):c.751G>T (p.Gly251Cys)
MISSENSE_VARIANT,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PSMC2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PSMC2 Gene

Variant ID Type Subtype PubMed ID
nsv5884 CNV insertion 18451855
nsv970926 CNV duplication 23825009

Variation tolerance for PSMC2 Gene

Residual Variation Intolerance Score: 25.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PSMC2 Gene

Human Gene Mutation Database (HGMD)
PSMC2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMC2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMC2 Gene

Disorders for PSMC2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PSMC2 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
alzheimer disease
  • ad
cystic fibrosis
  • cf
amyotrophic lateral sclerosis 1
  • als1
- elite association - COSMIC cancer census association via MalaCards
Search PSMC2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PSMC2

genes like me logo Genes that share disorders with PSMC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSMC2 Gene

Publications for PSMC2 Gene

  1. New human gene encoding a positive modulator of HIV Tat-mediated transactivation. (PMID: 1377363) Shibuya H … Matsumoto K (Nature 1992) 2 3 4 23
  2. Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases. (PMID: 9473509) Tanahashi N … Tanaka K (Biochemical and biophysical research communications 1998) 2 3 23
  3. An atomic structure of the human 26S proteasome. (PMID: 27428775) Huang X … Shi Y (Nature structural & molecular biology 2016) 3 4
  4. TRIM5α associates with proteasomal subunits in cells while in complex with HIV-1 virions. (PMID: 22078707) Lukic Z … Campbell EM (Retrovirology 2011) 3 4
  5. Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X … Huang L (Biochemistry 2007) 3 4

Products for PSMC2 Gene