Aliases for PSMC1 Gene
Aliases for PSMC1 Gene
External Ids for PSMC1 Gene
- HGNC: 9547
- Entrez Gene: 5700
- Ensembl: ENSG00000100764
- OMIM: 602706
- UniProtKB: P62191
Previous GeneCards Identifiers for PSMC1 Gene
- GC14P088228
- GC14P084538
- GC14P088712
- GC14P089792
- GC14P090722
- GC14P070897
Summaries for PSMC1 Gene
-
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder. [provided by RefSeq, Jul 2008]
GeneCards Summary for PSMC1 Gene
PSMC1 (Proteasome 26S Subunit, ATPase 1) is a Protein Coding gene. Among its related pathways are RET signaling and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include ATPase activity.
UniProtKB/Swiss-Prot for PSMC1 Gene
-
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMC1 Gene
Genomics for PSMC1 Gene
GeneHancer (GH) Regulatory Elements for PSMC1 Gene
Promoters and enhancers for PSMC1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH14I090255 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE | 550.8 | +0.4 | 374 | 1.9 | PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 POLR2B | PSMC1 KCNK13 GC14P090272 | |
| GH14I090330 | Promoter/Enhancer | 1.5 | Ensembl ENCODE | 11.7 | +75.3 | 75251 | 2.1 | PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 POLR2B ZNF766 | NRDE2 PSMC1 PIR47953 | |
| GH14I090296 | Enhancer | 0.9 | Ensembl ENCODE dbSUPER | 11.7 | +39.8 | 39810 | 1.4 | POLR2A MAX MYC ZBTB40 | PSMC1 NRDE2 KCNK13 PIR41665 PIR47953 | |
| GH14I090280 | Enhancer | 0.7 | ENCODE dbSUPER | 12.3 | +24.9 | 24946 | 1.8 | ZNF362 FOS ZNF600 EZH2 | NRDE2 PSMC1 CALM1 GC14M092131 PIR51620 | |
| GH14I090291 | Enhancer | 0.4 | ENCODE | 11.7 | +35.5 | 35520 | 0.9 | SCRT2 CREB1 CUX1 | PSMC1 PIR41665 PIR47953 NRDE2 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PSMC1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for PSMC1 Gene
Genomic Locations for PSMC1 Gene
- chr14:90,256,495-90,275,429
- (GRCh38/hg38)
- Size:
- 18,935 bases
- Orientation:
- Plus strand
- chr14:90,722,839-90,738,968
- (GRCh37/hg19)
Genomic View for PSMC1 Gene
Genes around PSMC1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q32.11 by Ensembl
- 14q32.11 by Entrez Gene
- 14q32.11 by HGNC
PSMC1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PSMC1 Gene
Proteins for PSMC1 Gene
-
Protein details for PSMC1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P62191-PRS4_HUMAN
- Recommended name:
- 26S proteasome regulatory subunit 4
- Protein Accession:
- P62191
- B4DR63
- P49014
- Q03527
- Q6IAW0
- Q6NW36
- Q96AZ3
Protein attributes for PSMC1 Gene
- Size:
- 440 amino acids
- Molecular mass:
- 49185 Da
- Quaternary structure:
-
- Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC1 and few additional components (PubMed:27428775, PubMed:27342858). Interacts with SCA7 (PubMed:11734547). Interacts with NGLY1 (PubMed:15358861). Interacts with PAAF1 (PubMed:15831487).
Three dimensional structures from OCA and Proteopedia for PSMC1 Gene
Protein Expression for PSMC1 Gene
Post-translational modifications for PSMC1 Gene
Other Protein References for PSMC1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for PSMC1
-
Abcam antibodies for PSMC1
-
Cloud-Clone Corp. Antibodies for PSMC1
- Invitrogen Antibodies for PSMC1
- GeneTex PSMC1 antibody for PSMC1
Protein Products
-
OriGene Purified Proteins for PSMC1
- Search Origene for MassSpec and Protein Over-expression Lysates for PSMC1
- Origene Custom Protein Services for PSMC1
-
Cloud-Clone Corp. Proteins for PSMC1
- Search GeneTex for Proteins for PSMC1
Assay Products
No data available for DME Specific Peptides for PSMC1 Gene
Domains & Families for PSMC1 Gene
Gene Families for PSMC1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for PSMC1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for PSMC1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ58247, highly similar to 26S protease regulatory subunit 4 (B4DR63_HUMAN)
- Proteasome 26S subunit ATPase 1 (PRS4_HUMAN)
- cDNA, FLJ93843, Homo sapiens proteasome (prosome, macropain) 26S subunit, ATPase, 1(PSMC1), mRNA (Q53XL8_HUMAN)
- Proteasome (Prosome, macropain) 26S subunit, ATPase, 1 (Q6NW36_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P62191- Family:
-
- Belongs to the AAA ATPase family.
Function for PSMC1 Gene
Molecular function for PSMC1 Gene
- GENATLAS Biochemistry:
- multicatalytic proteinase complex (prosome,macropain,26S) 19/225 regulator of proteasome,ATPase subunit,51kDa,? same as ATP1A3
- UniProtKB/Swiss-Prot Function:
- Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
Phenotypes From GWAS Catalog for PSMC1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003723 | RNA binding | IDA,HDA | 22658674 |
| GO:0005515 | protein binding | IPI | 9452483 |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for PSMC1 Gene
- MGI mutant phenotypes for PSMC1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for PSMC1:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Decreased NF-kappaB reporter expression
- FOXO1 nuclear localization
- Increased shRNA abundance (Z-score > 2)
- Increased G1 DNA content
- G0/1 arrest
- Decreased viability
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability of wild-type and TP53 knockout cells
- Upregulation of RLR pathway after Sendai virus (SeV) infection
- Downregulation of NFkappaB pathway
- HIV Rev nuclear localization
Animal Models for PSMC1 Gene
- MGI Knock Outs for PSMC1:
-
- Psmc1 tm1.1Maye
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PSMC1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for PSMC1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PSMC1 gene
- Search ViGene Biosciences for PSMC1
CRISPR Products
-
OriGene CRISPR knockouts for PSMC1
- genomics-online: gRNA clones - Search results for 145 available PSMC1 gene related products
- Overview of 145 available PSMC1 gene related products
- Applied Biological Materials CRISPR for PSMC1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSMC1
- GenScript: Design CRISPR guide RNA sequences for PSMC1
miRNA for PSMC1 Gene
- miRTarBase miRNAs that target PSMC1
-
- hsa-mir-26b-5p (MIRT028792)
- hsa-mir-342-5p (MIRT038229)
- hsa-mir-16-5p (MIRT051203)
- hsa-mir-7152-5p (MIRT649812)
- hsa-mir-3074-5p (MIRT649813)
- hsa-mir-580-3p (MIRT649814)
- hsa-mir-4713-5p (MIRT649815)
- hsa-mir-1200 (MIRT649816)
- hsa-mir-378a-5p (MIRT649817)
- hsa-mir-539-5p (MIRT649818)
- hsa-mir-2116-3p (MIRT649819)
- hsa-mir-532-3p (MIRT649820)
- hsa-mir-150-5p (MIRT649821)
- hsa-mir-1250-3p (MIRT649822)
miRNA Products
- Search ViGene Biosciences for PSMC1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PSMC1
- Browse OriGene Inhibitory RNA Products For PSMC1
- genomics-online: shRNA clones - Search results for 145 available PSMC1 gene related products
- Overview of 145 available PSMC1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PSMC1 gene
Clone Products
- Sino Biological Human cDNA Clone for PSMC1
- VectorBuilder custom plasmid, inducible vectors for PSMC1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PSMC1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PSMC1
- Applied Biological Materials Clones for PSMC1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for PSMC1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PSMC1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PSMC1 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PSMC1 Gene
Localization for PSMC1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PSMC1 Gene
- Cytoplasm. Nucleus. Membrane; Lipid-anchor.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| mitochondrion | 1 |
- Cytosol (4)
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000502 | proteasome complex | IDA,NAS | 17323924 |
| GO:0005634 | nucleus | IEA,HDA | 21630459 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for PSMC1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | CDK-mediated phosphorylation and removal of Cdc6 |
.93
.93
|
.80
.78
.78
.70
.47
.31
|
| 2 | RET signaling |
.92
|
.92
|
| 3 | Chks in Checkpoint Regulation | ||
| 4 | HIV Life Cycle |
.65
|
.45
|
| 5 | Class I MHC mediated antigen processing and presentation | ||
Pathways by source for PSMC1 Gene
1 Sino Biological pathway for PSMC1 Gene
2 BioSystems pathways for PSMC1 Gene
4 KEGG pathways for PSMC1 Gene
3 GeneGo (Thomson Reuters) pathways for PSMC1 Gene
19 Qiagen pathways for PSMC1 Gene
Interacting Proteins for PSMC1 Gene
Selected Interacting proteins:
ENSP00000261303
P62191-PRS4_HUMAN
for PSMC1 Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
| GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
| GO:0006457 | protein folding | TAS | -- |
No data available for SIGNOR curated interactions for PSMC1 Gene
Drugs & Compounds for PSMC1 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for PSMC1 Gene
mRNA/cDNA for PSMC1 Gene
- (4) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (687) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PSMC1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for PSMC1
- genomics-online: gRNA clones - Search results for 145 available PSMC1 gene related products
- Overview of 145 available PSMC1 gene related products
- Applied Biological Materials CRISPR for PSMC1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSMC1
- GenScript: Design CRISPR guide RNA sequences for PSMC1
miRNA Products
- Search ViGene Biosciences for PSMC1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PSMC1
- Browse OriGene Inhibitory RNA Products For PSMC1
- genomics-online: shRNA clones - Search results for 145 available PSMC1 gene related products
- Overview of 145 available PSMC1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PSMC1 gene
Clone Products
- Sino Biological Human cDNA Clone for PSMC1
- VectorBuilder custom plasmid, inducible vectors for PSMC1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PSMC1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PSMC1
- Applied Biological Materials Clones for PSMC1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for PSMC1 Gene
mRNA differential expression in normal tissues according to GTEx for PSMC1 Gene
This gene is overexpressed in Muscle - Skeletal (x4.0).
This gene is overexpressed in Lymph node (11.3) and Peripheral blood mononuclear cells (6.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSMC1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of PSMC1 Gene:
PSMC1SOURCE GeneReport for Unigene cluster for PSMC1 Gene:
Hs.356654Evidence on tissue expression from TISSUES for PSMC1 Gene
- Nervous system(4.8)
- Lung(4.6)
- Liver(4.4)
- Bone marrow(4.2)
- Muscle(2.4)
- Heart(2.3)
- Skin(2.1)
- Spleen(2.1)
- Kidney(2)
Primer Products
-
OriGene qPCR primer pairs for PSMC1
-
OriGene qPCR primer pairs and template standards for PSMC1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMC1 Gene
Orthologs for PSMC1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| oppossum (Monodelphis domestica) |
Mammalia | PSMC1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PSMC1 34 |
|
OneToOne | |
| chimpanzee (Pan troglodytes) |
Mammalia | PSMC1 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | PSMC1 33 34 |
|
||
| -- 34 |
|
OneToMany | |||
| mouse (Mus musculus) |
Mammalia | Psmc1 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Psmc1 33 |
|
||
| cow (Bos Taurus) |
Mammalia | PSMC1 33 34 |
|
||
| chicken (Gallus gallus) |
Aves | PSMC1 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | PSMC1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | psmc1 33 |
|
||
| Str.4828 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | pros26.4-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | psmc1b 34 |
|
OneToMany | |
| psmc1a 33 34 |
|
||||
| wufb05d04 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Pros26.4 35 33 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003216 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | rpt-2 33 34 |
|
||
| C10G11.8 35 |
|
|
|||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F14707g 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RPT2 33 34 36 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AEL011W 33 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT2G20140 33 |
|
||
| soybean (Glycine max) |
eudicotyledons | Gma.11305 33 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.6904 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os07g0691800 33 |
|
||
| Os.144 33 |
|
||||
| barley (Hordeum vulgare) |
Liliopsida | Hv.12805 33 |
|
||
| wheat (Triticum aestivum) |
Liliopsida | Ta.6566 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3260 34 |
|
OneToOne | |
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rpt2 33 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU11271 33 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.4829 33 |
|
- Species where no ortholog for PSMC1 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Paralogs for PSMC1 Gene
(23) SIMAP similar genes for PSMC1 Gene using alignment to 4 proteins:
Pseudogenes.org Pseudogenes for PSMC1 Gene
No data available for Paralogs for PSMC1 Gene
Variants for PSMC1 Gene
| SNP ID | Clin | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs193920988 | uncertain-significance, Malignant tumor of prostate | 90,263,450(+) | G/A/T | intron_variant | |
| rs1000082175 | -- | 90,256,022(+) | G/A | upstream_transcript_variant | |
| rs1000110869 | -- | 90,268,708(+) | G/A | intron_variant | |
| rs1000133252 | -- | 90,255,663(+) | C/A/T | upstream_transcript_variant | |
| rs1000187243 | -- | 90,260,508(+) | G/A | intron_variant |
Residual Variation Intolerance Score:
43.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.12;
2.73% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PSMC1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PSMC1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMC1 Gene
Disorders for PSMC1 Gene
Additional Disease Information for PSMC1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for PSMC1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMC1 Gene
Publications for PSMC1 Gene
- Association of ataxin-7 with the proteasome subunit S4 of the 19S regulatory complex. (PMID: 11734547) Matilla A … Fu YH (Human molecular genetics 2001) 3 4 22 58
- Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases. (PMID: 9473509) Tanahashi N … Tanaka K (Biochemical and biophysical research communications 1998) 2 3 22 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X … Huang L (Biochemistry 2007) 3 4 58
- Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases. (PMID: 15831487) Park Y … Yoon JB (Molecular and cellular biology 2005) 3 4 58
Products for PSMC1 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for PSMC1
- Search Origene for MassSpec and Protein Over-expression Lysates for PSMC1
- Origene Custom Protein Services for PSMC1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PSMC1
- Browse OriGene Inhibitory RNA Products For PSMC1
- OriGene qPCR primer pairs and template standards for PSMC1
- OriGene qPCR primer pairs for PSMC1
- OriGene CRISPR knockouts for PSMC1
- OriGene ORF clones in human for PSMC1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PSMC1
- GenScript: Next-day shipping of latest version cDNA ORF clones for PSMC1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for PSMC1
- GenScript Custom Assay Services for PSMC1
- GenScript Custom overexpressing Cell Line Services for PSMC1
- GenScript: Design CRISPR guide RNA sequences for PSMC1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for PSMC1
- Sino Biological Human cDNA Clone for PSMC1
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for PSMC1
- Novus Biologicals lysates and proteins for PSMC1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for PSMC1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Cloud-Clone Corp. Antibodies for PSMC1
- Cloud-Clone Corp. Proteins for PSMC1
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for PSMC1
- VectorBuilder custom plasmid, inducible vectors for PSMC1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PSMC1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PSMC1
- antibodies-online: Search results for 29 available PSMC1 Antibodies ranked by validation data
- Compare Top PSMC1 Antibodies
- antibodies-online: Search results for available PSMC1 related products ranked by validation data
- antibodies-online: Search results for 6 available PSMC1 Proteins ranked by validation data
- Compare Top PSMC1 Proteins
- GeneTex PSMC1 antibody for PSMC1
- Search GeneTex for Proteins for PSMC1
- ViGene Biosciences adenoviral particle packaged cDNA for PSMC1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for PSMC1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for PSMC1 gene
- Search ViGene Biosciences for PSMC1
- genomics-online: cdna clones - Search results for 145 available PSMC1 gene related products
- Overview of 145 available PSMC1 gene related products
- orf clones - Search results for 145 available PSMC1 gene related products
- Overview of 145 available PSMC1 gene related products
- genomics-online: gRNA clones - Search results for 145 available PSMC1 gene related products
- Overview of 145 available PSMC1 gene related products
- genomics-online: primer clones - Search results for 145 available PSMC1 gene related products
- Overview of 145 available PSMC1 gene related products
- genomics-online: shRNA clones - Search results for 145 available PSMC1 gene related products
- Overview of 145 available PSMC1 gene related products
Sources for PSMC1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems