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The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 n... See more...
Aliases for PSMC1 Gene
Aliases for PSMC1 Gene
External Ids for PSMC1 Gene
- HGNC: 9547
- Entrez Gene: 5700
- Ensembl: ENSG00000100764
- OMIM: 602706
- UniProtKB: P62191
Previous GeneCards Identifiers for PSMC1 Gene
- GC14P088228
- GC14P084538
- GC14P088712
- GC14P089792
- GC14P090722
- GC14P070897
Summaries for PSMC1 Gene
-
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder. [provided by RefSeq, Jul 2008]
GeneCards Summary for PSMC1 Gene
PSMC1 (Proteasome 26S Subunit, ATPase 1) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and RET signaling. Gene Ontology (GO) annotations related to this gene include ATPase activity. An important paralog of this gene is PSMC4.
UniProtKB/Swiss-Prot Summary for PSMC1 Gene
-
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSMC1 Gene
Genomics for PSMC1 Gene
GeneHancer (GH) Regulatory Elements for PSMC1 Gene
Promoters and enhancers for PSMC1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH14J090255 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE CraniofacialAtlas | 500.7 | +0.6 | 574 | 2.6 | ZBTB40 ZNF217 SIN3A POLR2G SP1 GTF2E2 PHF8 ZFX SIX5 REST | PSMC1 TDP1 KCNK13 piR-57621 | |
| GH14J090330 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE CraniofacialAtlas | 11.7 | +75.2 | 75173 | 2.2 | ZNF217 EP300 NRF1 TCF12 POLR2G GTF2E2 PHF8 SIX5 ZFX ZNF639 | NRDE2 lnc-TTC7B-9 PSMC1 FJ601684-121 | |
| GH14J090294 | Enhancer | 1.4 | FANTOM5 Ensembl ENCODE dbSUPER | 11.7 | +43.0 | 42974 | 13.4 | HNRNPK EP300 CTCF USF1 TCF7 REST RAD21 ZSCAN9 PCBP1 FOXA2 | NRDE2 CALM1 PSMC1 KCNK13 ENSG00000287437 piR-53954 | |
| GH14J090280 | Enhancer | 0.8 | Ensembl ENCODE dbSUPER | 12.3 | +24.9 | 24941 | 1.9 | FOS MAFK NFE2L2 ZNF362 EZH2 ZNF600 | NRDE2 PSMC1 CALM1 piR-57621 piR-48666 | |
| GH14J090289 | Enhancer | 0.4 | Ensembl dbSUPER | 11.7 | +34.4 | 34374 | 1 | CEBPB | ENSG00000287437 NRDE2 PSMC1 CALM1 piR-48666 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PSMC1 on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PSMC1
- Top Transcription factor binding sites by QIAGEN in the PSMC1 gene promoter:
-
- AML1a
- AP-1
- AP-4
- ATF
- c-Fos
- c-Jun
- CUTL1
- FOXJ2
- FOXJ2 (long isoform)
- HTF
Genomic Locations for PSMC1 Gene
Genomic Locations for PSMC1 Gene
- chr14:90,256,527-90,275,429
- (GRCh38/hg38)
- Size:
- 18,903 bases
- Orientation:
- Plus strand
- chr14:90,722,839-90,738,968
- (GRCh37/hg19)
- Size:
- 16,130 bases
- Orientation:
- Plus strand
Genomic View for PSMC1 Gene
Genes around PSMC1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q32.11 by HGNC
- 14q32.11 by Entrez Gene
- 14q32.11 by Ensembl
PSMC1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PSMC1 Gene
Proteins for PSMC1 Gene
-
Protein details for PSMC1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P62191-PRS4_HUMAN
- Recommended name:
- 26S proteasome regulatory subunit 4
- Protein Accession:
- P62191
- B4DR63
- P49014
- Q03527
- Q6IAW0
- Q6NW36
- Q96AZ3
Protein attributes for PSMC1 Gene
- Size:
- 440 amino acids
- Molecular mass:
- 49185 Da
- Quaternary structure:
-
- Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC1 and few additional components (PubMed:27428775, PubMed:27342858). Interacts with SCA7 (PubMed:11734547). Interacts with NGLY1 (PubMed:15358861). Interacts with PAAF1 (PubMed:15831487).
Three dimensional structures from OCA and Proteopedia for PSMC1 Gene
Protein Expression for PSMC1 Gene
Post-translational modifications for PSMC1 Gene
Other Protein References for PSMC1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-PSMC1 monoclonal antibody
- Creative Biolabs Recombinant Anti-Human PSMC1 Antibody
- Novus Biologicals Antibodies for PSMC1
-
Abcam antibodies for PSMC1
- Invitrogen Antibodies for PSMC1 (AFLGC-PSMC1)
-
Boster Bio Antibodies for PSMC1
Protein Products
- Creative Biomart Recombinant Human PSMC1, His-tagged
- Search Origene for MassSpec and Protein Over-expression Lysates for PSMC1
- Origene Custom Protein Services for PSMC1
-
Signalway Proteins for PSMC1
No data available for DME Specific Peptides for PSMC1 Gene
Domains & Families for PSMC1 Gene
Gene Families for PSMC1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for PSMC1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for PSMC1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ58247, highly similar to 26S protease regulatory subunit 4 (B4DR63_HUMAN)
- Proteasome 26S subunit ATPase 1 (PRS4_HUMAN)
- cDNA, FLJ93843, Homo sapiens proteasome (prosome, macropain) 26S subunit, ATPase, 1(PSMC1), mRNA (Q53XL8_HUMAN)
- Proteasome (Prosome, macropain) 26S subunit, ATPase, 1 (Q6NW36_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P62191- Family:
-
- Belongs to the AAA ATPase family.
Function for PSMC1 Gene
Molecular function for PSMC1 Gene
- UniProtKB/Swiss-Prot Function:
- Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
- GENATLAS Biochemistry:
- multicatalytic proteinase complex (prosome,macropain,26S) 19/225 regulator of proteasome,ATPase subunit,51kDa,? same as ATP1A3
Phenotypes From GWAS Catalog for PSMC1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0005515 | protein binding | IPI | 9452483 |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for PSMC1 Gene
- MGI mutant phenotypes for PSMC1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for PSMC1:
-
- G0/1 arrest
- Increased G2M DNA content, increased 8N DNA content
- Increased shRNA abundance (Z-score > 2)
- Decreased viability of wild-type and TP53 knockout cells, decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Reduced mammosphere formation
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Upregulation of RLR pathway after Sendai virus (SeV) infection
- Downregulation of NFkappaB pathway
- Decreased shRNA abundance (Z-score < -2)
- Decreased NF-kappaB reporter expression
- shRNA abundance <= 50%
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- FOXO1 nuclear localization
- HIV Rev nuclear localization
Animal Models for PSMC1 Gene
- MGI Knock Outs for PSMC1:
-
- Psmc1 Psmc1<tm1.1Maye>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PSMC1 - Select products 50% OFF >
- * PSMC1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PSMC1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PSMC1
- genomics-online: gRNA clones - Search for available PSMC1 gRNA products
- Overview of 163 available PSMC1 gene related products
-
Recommended
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSMC1
miRNA for PSMC1 Gene
- miRTarBase miRNAs that target PSMC1
-
- hsa-mir-26b-5p (MIRT028792)
- hsa-mir-342-5p (MIRT038229)
- hsa-mir-16-5p (MIRT051203)
- hsa-mir-7152-5p (MIRT649812)
- hsa-mir-3074-5p (MIRT649813)
- hsa-mir-580-3p (MIRT649814)
- hsa-mir-4713-5p (MIRT649815)
- hsa-mir-1200 (MIRT649816)
- hsa-mir-378a-5p (MIRT649817)
- hsa-mir-539-5p (MIRT649818)
- hsa-mir-2116-3p (MIRT649819)
- hsa-mir-532-3p (MIRT649820)
- hsa-mir-150-5p (MIRT649821)
- hsa-mir-1250-3p (MIRT649822)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PSMC1
- Browse OriGene Inhibitory RNA Products For PSMC1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMC1
- genomics-online: shRNA clones - Search for available PSMC1 shRNA products
- Overview of 163 available PSMC1 gene related products
-
Recommended
Clone Products
- Applied Biological Materials (abm): Clones for PSMC1 - Select products 50% OFF >
- * PSMC1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PSMC1
- Addgene plasmids for PSMC1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PSMC1
- genomics-online: cdna clones - Search for available PSMC1 CDNA products
- Overview of 163 available PSMC1 gene related products
-
Recommended
- orf clones - Search for available PSMC1 ORF products
- Overview of 163 available PSMC1 gene related products
-
Recommended
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PSMC1 Gene
Localization for PSMC1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PSMC1 Gene
- Cytoplasm. Nucleus. Membrane; Lipid-anchor.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| mitochondrion | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
- Cytosol (4)
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000502 | proteasome complex | IDA,NAS | 17323924 |
| GO:0005634 | nucleus | HDA,IEA | 21630459 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for PSMC1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | CDK-mediated phosphorylation and removal of Cdc6 |
.93
.93
|
.80
.78
.78
.70
.47
.31
|
| 2 | RET signaling |
.92
|
.92
|
| 3 | Chks in Checkpoint Regulation |
Chks in Checkpoint Regulation
.59
G2-M Phase Transition
.59
Estrogen-mediated S-Phase Entry
.55
|
SREBP Proteolysis
.43
DNA Repair Mechanisms
.32
Parkinson's Disease Pathway
.31
|
| 4 | HIV Life Cycle |
.64
|
.45
|
| 5 | Class I MHC mediated antigen processing and presentation | ||
Pathways by source for PSMC1 Gene
1 Sino Biological pathway for PSMC1 Gene
2 BioSystems pathways for PSMC1 Gene
4 KEGG pathways for PSMC1 Gene
3 GeneGo (Thomson Reuters) pathways for PSMC1 Gene
- Immune response Antigen presentation by MHC class I
- Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
- Transcription Ligand-Dependent Transcription of Retinoid-Target genes
19 Qiagen pathways for PSMC1 Gene
- CDK5 Pathway
- Chks in Checkpoint Regulation
- DNA Repair Mechanisms
- Estrogen-mediated S-Phase Entry
- G2-M Phase Transition
Interacting Proteins for PSMC1 Gene
Selected Interacting proteins:
P62191-PRS4_HUMAN
ENSP00000261303
for PSMC1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for PSMC1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
| GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
| GO:0006457 | protein folding | TAS | -- |
No data available for SIGNOR curated interactions for PSMC1 Gene
Drugs & Compounds for PSMC1 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
- Creative Biomart Recombinant Human PSMC1, His-tagged
Transcripts for PSMC1 Gene
mRNA/cDNA for PSMC1 Gene
- 2 REFSEQ mRNAs :
- 17 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000261303 4390 bps (ENST00000261303.13)
- ENST00000543772 1389 bps (ENST00000543772.2)
- ENST00000553835 390 bps (ENST00000553835.5)
- ENST00000554624 577 bps (ENST00000554624.5)
- ENST00000555679 606 bps (ENST00000555679.5)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PSMC1 - Select products 50% OFF >
- * PSMC1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PSMC1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PSMC1
- genomics-online: gRNA clones - Search for available PSMC1 gRNA products
- Overview of 163 available PSMC1 gene related products
-
Recommended
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSMC1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PSMC1
- Browse OriGene Inhibitory RNA Products For PSMC1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMC1
- genomics-online: shRNA clones - Search for available PSMC1 shRNA products
- Overview of 163 available PSMC1 gene related products
-
Recommended
Clone Products
- Applied Biological Materials (abm): Clones for PSMC1 - Select products 50% OFF >
- * PSMC1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PSMC1
- Addgene plasmids for PSMC1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PSMC1
- genomics-online: cdna clones - Search for available PSMC1 CDNA products
- Overview of 163 available PSMC1 gene related products
-
Recommended
- orf clones - Search for available PSMC1 ORF products
- Overview of 163 available PSMC1 gene related products
-
Recommended
Relevant External Links for PSMC1 Gene
- GeneLoc Exon Structure for
- PSMC1
Expression for PSMC1 Gene
mRNA differential expression in normal tissues according to GTEx for PSMC1 Gene
This gene is overexpressed in Muscle - Skeletal (x4.0).
This gene is overexpressed in Lymph node (11.3) and Peripheral blood mononuclear cells (6.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMC1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PSMC1
SOURCE GeneReport for Unigene cluster for PSMC1 Gene:
Hs.356654Evidence on tissue expression from TISSUES for PSMC1 Gene
- Nervous system(4.8)
- Lung(4.6)
- Liver(4.4)
- Bone marrow(4.2)
- Muscle(2.4)
- Heart(2.3)
- Skin(2.1)
- Spleen(2.1)
- Kidney(2)
Primer Products
-
OriGene qPCR primer pairs for PSMC1
-
OriGene qPCR primer pairs and template standards for PSMC1
- genomics-online: primer clones - Search for available PSMC1 Primer products
- Overview of 163 available PSMC1 gene related products
-
Recommended
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMC1 Gene
Orthologs for PSMC1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| oppossum (Monodelphis domestica) |
Mammalia | PSMC1 31 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PSMC1 31 |
|
OneToOne | |
| chimpanzee (Pan troglodytes) |
Mammalia | PSMC1 31 30 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | PSMC1 31 30 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| mouse (Mus musculus) |
Mammalia | Psmc1 17 31 30 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Psmc1 30 |
|
||
| cow (Bos Taurus) |
Mammalia | PSMC1 31 30 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PSMC1 31 30 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | PSMC1 31 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | psmc1 30 |
|
||
| Str.4828 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | pros26.4-prov 30 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | psmc1b 31 |
|
OneToMany | |
| psmc1a 31 30 |
|
OneToMany | |||
| wufb05d04 30 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Pros26.4 31 32 30 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003215 30 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | rpt-2 31 30 |
|
OneToOne | |
| C10G11.8 32 |
|
|
|||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F14707g 30 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RPT2 33 31 30 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AEL011W 30 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT2G20140 30 |
|
||
| soybean (Glycine max) |
eudicotyledons | Gma.11305 30 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.6904 30 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os07g0691800 30 |
|
||
| Os.144 30 |
|
||||
| wheat (Triticum aestivum) |
Liliopsida | Ta.6566 30 |
|
||
| barley (Hordeum vulgare) |
Liliopsida | Hv.12805 30 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3260 31 |
|
OneToOne | |
| Cin.4829 30 |
|
||||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rpt2 30 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU11271 30 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.4829 30 |
|
- Species where no ortholog for PSMC1 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Evolution for PSMC1 Gene
- ENSEMBL:
- Gene Tree for PSMC1 (if available)
- TreeFam:
- Gene Tree for PSMC1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PSMC1: view image
Paralogs for PSMC1 Gene
(23) SIMAP similar genes for PSMC1 Gene using alignment to 4 proteins:
- PRS4_HUMAN
- B4DR63_HUMAN
- G3V4X1_HUMAN
- Q53XL8_HUMAN
Pseudogenes.org Pseudogenes for PSMC1 Gene
Variants for PSMC1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PSMC1 Gene
| SNP ID | Clinical significance and condition | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 770241 | Benign: not provided | 90,263,394(+) | A/G | SYNONYMOUS_VARIANT | |
| rs193920988 | Uncertain Significance: Malignant tumor of prostate | 90,263,450(+) | G/A | INTRON_VARIANT |
Residual Variation Intolerance Score:
43.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.12;
2.73% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PSMC1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PSMC1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMC1 Gene
Disorders for PSMC1 Gene
Additional Disease Information for PSMC1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for PSMC1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMC1 Gene
Publications for PSMC1 Gene
- Association of ataxin-7 with the proteasome subunit S4 of the 19S regulatory complex. (PMID: 11734547) Matilla A … Fu YH (Human molecular genetics 2001) 3 4 23 54
- Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases. (PMID: 9473509) Tanahashi N … Tanaka K (Biochemical and biophysical research communications 1998) 2 3 23 54
- An atomic structure of the human 26S proteasome. (PMID: 27428775) Huang X … Shi Y (Nature structural & molecular biology 2016) 3 4 54
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
- Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X … Huang L (Biochemistry 2007) 3 4 54
ExternalLinks
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