Aliases for PSMC1 Gene
Aliases for PSMC1 Gene
External Ids for PSMC1 Gene
- HGNC: 9547
- Entrez Gene: 5700
- Ensembl: ENSG00000100764
- OMIM: 602706
- UniProtKB: P62191
Previous GeneCards Identifiers for PSMC1 Gene
- GC14P088228
- GC14P084538
- GC14P088712
- GC14P089792
- GC14P090722
- GC14P070897
Summaries for PSMC1 Gene
-
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder. [provided by RefSeq, Jul 2008]
GeneCards Summary for PSMC1 Gene
PSMC1 (Proteasome 26S Subunit, ATPase 1) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and RET signaling. Gene Ontology (GO) annotations related to this gene include ATPase activity.
UniProtKB/Swiss-Prot for PSMC1 Gene
-
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMC1 Gene
Genomics for PSMC1 Gene
GeneHancer (GH) Regulatory Elements for PSMC1 Gene
Promoters and enhancers for PSMC1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around PSMC1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PSMC1 gene promoter:
-
- c-Jun
- c-Fos
- AP-1
- AP-4
- AML1a
- ATF
- FOXJ2 (long isoform)
- FOXJ2
- HTF
- CUTL1
Regulatory Element Products
Genomic Locations for PSMC1 Gene
Genomic Locations for PSMC1 Gene
- chr14:90,256,495-90,275,429
- (GRCh38/hg38)
- Size:
- 18,935 bases
- Orientation:
- Plus strand
- chr14:90,722,839-90,738,968
- (GRCh37/hg19)
- Size:
- 16,130 bases
- Orientation:
- Plus strand
Genomic View for PSMC1 Gene
Genes around PSMC1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q32.11 by Entrez Gene
- 14q32.11 by HGNC
- 14q32.11 by Ensembl
PSMC1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PSMC1 Gene
Proteins for PSMC1 Gene
-
Protein details for PSMC1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P62191-PRS4_HUMAN
- Recommended name:
- 26S proteasome regulatory subunit 4
- Protein Accession:
- P62191
- B4DR63
- P49014
- Q03527
- Q6IAW0
- Q6NW36
- Q96AZ3
Protein attributes for PSMC1 Gene
- Size:
- 440 amino acids
- Molecular mass:
- 49185 Da
- Quaternary structure:
-
- Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC1 and few additional components (PubMed:27428775, PubMed:27342858). Interacts with SCA7 (PubMed:11734547). Interacts with NGLY1 (PubMed:15358861). Interacts with PAAF1 (PubMed:15831487).
Three dimensional structures from OCA and Proteopedia for PSMC1 Gene
Protein Expression for PSMC1 Gene
Post-translational modifications for PSMC1 Gene
Other Protein References for PSMC1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for PSMC1
-
Abcam antibodies for PSMC1
- Invitrogen Antibodies for PSMC1
- GeneTex PSMC1 Antibody for PSMC1
-
Boster Bio Antibodies for PSMC1
Protein Products
-
OriGene Purified Proteins for PSMC1
- Search Origene for MassSpec and Protein Over-expression Lysates for PSMC1
- Origene Custom Protein Services for PSMC1
- Search GeneTex for Proteins for PSMC1
Assay Products
No data available for DME Specific Peptides for PSMC1 Gene
Domains & Families for PSMC1 Gene
Gene Families for PSMC1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for PSMC1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for PSMC1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ58247, highly similar to 26S protease regulatory subunit 4 (B4DR63_HUMAN)
- Proteasome 26S subunit ATPase 1 (PRS4_HUMAN)
- cDNA, FLJ93843, Homo sapiens proteasome (prosome, macropain) 26S subunit, ATPase, 1(PSMC1), mRNA (Q53XL8_HUMAN)
- Proteasome (Prosome, macropain) 26S subunit, ATPase, 1 (Q6NW36_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P62191- Family:
-
- Belongs to the AAA ATPase family.
Function for PSMC1 Gene
Molecular function for PSMC1 Gene
- UniProtKB/Swiss-Prot Function:
- Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
- GENATLAS Biochemistry:
- multicatalytic proteinase complex (prosome,macropain,26S) 19/225 regulator of proteasome,ATPase subunit,51kDa,? same as ATP1A3
Phenotypes From GWAS Catalog for PSMC1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0005515 | protein binding | IPI | 9374493 |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for PSMC1 Gene
- MGI mutant phenotypes for PSMC1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for PSMC1:
-
- G0/1 arrest
- Increased G1 DNA content
- Increased shRNA abundance (Z-score > 2)
- Decreased viability of wild-type and TP53 knockout cells, decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Reduced mammosphere formation
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Upregulation of RLR pathway after Sendai virus (SeV) infection
- Downregulation of NFkappaB pathway
- Decreased NF-kappaB reporter expression
- shRNA abundance <= 50%
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- FOXO1 nuclear localization
- HIV Rev nuclear localization
Animal Models for PSMC1 Gene
- MGI Knock Outs for PSMC1:
-
- Psmc1 Psmc1<tm1.1Maye>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PSMC1
-
CRISPR Products
-
OriGene CRISPR knockouts for PSMC1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PSMC1
- genomics-online: gRNA clones - Search results for 145 available PSMC1 gene related products
- Overview of 145 available PSMC1 gene related products
- Applied Biological Materials CRISPR for PSMC1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSMC1
- GenScript: Design CRISPR guide RNA sequences for PSMC1
miRNA for PSMC1 Gene
- miRTarBase miRNAs that target PSMC1
-
- hsa-mir-26b-5p (MIRT028792)
- hsa-mir-342-5p (MIRT038229)
- hsa-mir-16-5p (MIRT051203)
- hsa-mir-7152-5p (MIRT649812)
- hsa-mir-3074-5p (MIRT649813)
- hsa-mir-580-3p (MIRT649814)
- hsa-mir-4713-5p (MIRT649815)
- hsa-mir-1200 (MIRT649816)
- hsa-mir-378a-5p (MIRT649817)
- hsa-mir-539-5p (MIRT649818)
- hsa-mir-2116-3p (MIRT649819)
- hsa-mir-532-3p (MIRT649820)
- hsa-mir-150-5p (MIRT649821)
- hsa-mir-1250-3p (MIRT649822)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for PSMC1
- Browse OriGene Inhibitory RNA Products For PSMC1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMC1
- genomics-online: shRNA clones - Search results for 145 available PSMC1 gene related products
- Overview of 145 available PSMC1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for PSMC1
- VectorBuilder custom plasmid, inducible vectors for PSMC1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PSMC1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PSMC1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PSMC1
- Applied Biological Materials Clones for PSMC1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PSMC1 Gene
Localization for PSMC1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PSMC1 Gene
- Cytoplasm. Nucleus. Membrane; Lipid-anchor.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| mitochondrion | 1 |
- Cytosol (4)
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000502 | proteasome complex | IDA,NAS | 17323924 |
| GO:0005634 | nucleus | IEA,HDA | 21630459 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for PSMC1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | CDK-mediated phosphorylation and removal of Cdc6 |
.93
.93
|
.80
.78
.78
.70
.47
.31
|
| 2 | RET signaling |
.92
|
.92
|
| 3 | Chks in Checkpoint Regulation | ||
| 4 | HIV Life Cycle |
.64
|
.45
|
| 5 | Class I MHC mediated antigen processing and presentation | ||
Pathways by source for PSMC1 Gene
1 Sino Biological pathway for PSMC1 Gene
2 BioSystems pathways for PSMC1 Gene
4 KEGG pathways for PSMC1 Gene
3 GeneGo (Thomson Reuters) pathways for PSMC1 Gene
19 Qiagen pathways for PSMC1 Gene
Interacting Proteins for PSMC1 Gene
Selected Interacting proteins:
P62191-PRS4_HUMAN
ENSP00000261303
for PSMC1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for PSMC1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
| GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
| GO:0006457 | protein folding | TAS | -- |
No data available for SIGNOR curated interactions for PSMC1 Gene
Drugs & Compounds for PSMC1 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for PSMC1 Gene
mRNA/cDNA for PSMC1 Gene
- (3) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (687) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000261303 4448 bps (uc001xyf.4)
- ENST00000553835 390 bps (uc059efx.1)
- ENST00000554624 577 bps (uc059efy.1)
- ENST00000557357 581 bps (uc059efz.1)
- ENST00000555679 606 bps (uc059ega.1)
Unigene Clusters for PSMC1 Gene
- Proteasome (prosome, macropain) 26S subunit, ATPase, 1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for PSMC1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PSMC1
- genomics-online: gRNA clones - Search results for 145 available PSMC1 gene related products
- Overview of 145 available PSMC1 gene related products
- Applied Biological Materials CRISPR for PSMC1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSMC1
- GenScript: Design CRISPR guide RNA sequences for PSMC1
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for PSMC1
- Browse OriGene Inhibitory RNA Products For PSMC1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMC1
- genomics-online: shRNA clones - Search results for 145 available PSMC1 gene related products
- Overview of 145 available PSMC1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for PSMC1
- VectorBuilder custom plasmid, inducible vectors for PSMC1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PSMC1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PSMC1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PSMC1
- Applied Biological Materials Clones for PSMC1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for PSMC1 Gene
mRNA differential expression in normal tissues according to GTEx for PSMC1 Gene
This gene is overexpressed in Muscle - Skeletal (x4.0).
This gene is overexpressed in Lymph node (11.3) and Peripheral blood mononuclear cells (6.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMC1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of PSMC1 Gene:
PSMC1SOURCE GeneReport for Unigene cluster for PSMC1 Gene:
Hs.356654Evidence on tissue expression from TISSUES for PSMC1 Gene
- Nervous system(4.8)
- Lung(4.6)
- Liver(4.4)
- Bone marrow(4.2)
- Muscle(2.4)
- Heart(2.3)
- Skin(2.1)
- Spleen(2.1)
- Kidney(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for PSMC1
-
OriGene qPCR primer pairs for PSMC1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMC1 Gene
Orthologs for PSMC1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| platypus (Ornithorhynchus anatinus) |
Mammalia | PSMC1 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | PSMC1 34 |
|
OneToOne | |
| chimpanzee (Pan troglodytes) |
Mammalia | PSMC1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | PSMC1 34 33 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| mouse (Mus musculus) |
Mammalia | Psmc1 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Psmc1 33 |
|
||
| cow (Bos Taurus) |
Mammalia | PSMC1 34 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PSMC1 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | PSMC1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | psmc1 33 |
|
||
| Str.4828 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | pros26.4-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | psmc1b 34 |
|
OneToMany | |
| psmc1a 34 33 |
|
OneToMany | |||
| wufb05d04 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Pros26.4 34 35 33 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003216 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | rpt-2 34 33 |
|
OneToOne | |
| C10G11.8 35 |
|
|
|||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F14707g 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RPT2 36 34 33 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AEL011W 33 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT2G20140 33 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.6904 33 |
|
||
| soybean (Glycine max) |
eudicotyledons | Gma.11305 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os07g0691800 33 |
|
||
| Os.144 33 |
|
||||
| barley (Hordeum vulgare) |
Liliopsida | Hv.12805 33 |
|
||
| wheat (Triticum aestivum) |
Liliopsida | Ta.6566 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3260 34 |
|
OneToOne | |
| Cin.4829 33 |
|
||||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rpt2 33 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU11271 33 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.4829 33 |
|
- Species where no ortholog for PSMC1 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Evolution for PSMC1 Gene
- ENSEMBL:
- Gene Tree for PSMC1 (if available)
- TreeFam:
- Gene Tree for PSMC1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PSMC1: view image
Paralogs for PSMC1 Gene
(23) SIMAP similar genes for PSMC1 Gene using alignment to 4 proteins:
- PRS4_HUMAN
- B4DR63_HUMAN
- G3V4X1_HUMAN
- Q53XL8_HUMAN
Pseudogenes.org Pseudogenes for PSMC1 Gene
No data available for Paralogs for PSMC1 Gene
Variants for PSMC1 Gene
| SNP ID | Clin | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs193920988 | uncertain-significance, Malignant tumor of prostate | 90,263,450(+) | G/A/T | intron_variant | |
| rs1000082175 | -- | 90,256,022(+) | G/A | upstream_transcript_variant | |
| rs1000110869 | -- | 90,268,708(+) | G/A | intron_variant | |
| rs1000133252 | -- | 90,255,663(+) | C/A/T | upstream_transcript_variant | |
| rs1000187243 | -- | 90,260,508(+) | G/A | intron_variant |
Residual Variation Intolerance Score:
43.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.12;
2.73% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PSMC1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PSMC1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMC1 Gene
Disorders for PSMC1 Gene
Additional Disease Information for PSMC1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for PSMC1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMC1 Gene
Publications for PSMC1 Gene
- Association of ataxin-7 with the proteasome subunit S4 of the 19S regulatory complex. (PMID: 11734547) Matilla A … Fu YH (Human molecular genetics 2001) 3 4 22 58
- Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases. (PMID: 9473509) Tanahashi N … Tanaka K (Biochemical and biophysical research communications 1998) 2 3 22 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X … Huang L (Biochemistry 2007) 3 4 58
- Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases. (PMID: 15831487) Park Y … Yoon JB (Molecular and cellular biology 2005) 3 4 58
Products for PSMC1 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for PSMC1
- Search Origene for MassSpec and Protein Over-expression Lysates for PSMC1
- Origene Custom Protein Services for PSMC1
- Origene sirna, shrna, and RNAi products in human, mouse, rat for PSMC1
- Browse OriGene Inhibitory RNA Products For PSMC1
- OriGene qPCR primer pairs and template standards for PSMC1
- OriGene qPCR primer pairs for PSMC1
- OriGene CRISPR knockouts for PSMC1
- OriGene ORF clones in human for PSMC1
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