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The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiq... See more...
Aliases for PSMB9 Gene
Aliases for PSMB9 Gene
- Proteasome 20S Subunit Beta 9 2 3 5
- PSMB6i 2 3 4
- RING12 2 3 4
- Multicatalytic Endopeptidase Complex Chain 7 3 4
- Really Interesting New Gene 12 Protein 3 4
- Large Multifunctional Peptidase 2 2 3
- Proteasome Subunit Beta Type-9 3 4
- Low Molecular Mass Protein 2 3 4
- Proteasome Subunit Beta-1i 3 4
- Proteasome Subunit Beta 9 2 3
- Proteasome Chain 7 3 4
- Macropain Chain 7 3 4
- EC 3.4.25.1 4 51
- Beta1i 2 3
- LMP2 3 4
- Proteasome (Prosome, Macropain) Subunit, Beta Type, 9 (Large Multifunctional Peptidase 2) 3
- Proteasome (Prosome, Macropain) Subunit, Beta Type, 9 (Large Multifunctional Protease 2) 2
- Proteasome (Prosome, Macropain) Subunit, Beta Type, 9 2
- Proteasome Catalytic Subunit 1i 3
- Proteasome Subunit Beta 6i 3
- Proteasome Subunit Beta1i 3
- Proteasome-Related Gene 2 3
- Proteasome Subunit Β1i 2
- PRAAS3 3
- PSMB9 5
External Ids for PSMB9 Gene
- HGNC: 9546
- Entrez Gene: 5698
- Ensembl: ENSG00000240065
- OMIM: 177045
- UniProtKB: P28065
Previous HGNC Symbols for PSMB9 Gene
- LMP2
Previous GeneCards Identifiers for PSMB9 Gene
- GC06P032818
- GC06P032582
- GC06P032868
- GC06P032929
- GC06P032812
- GC06P032815
- GC06P032821
- GC06P032825
- GC06P032845
- GC06P032977
- GC06P033443
Summaries for PSMB9 Gene
-
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 1 (proteasome beta 6 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. [provided by RefSeq, Mar 2010]
GeneCards Summary for PSMB9 Gene
PSMB9 (Proteasome 20S Subunit Beta 9) is a Protein Coding gene. Diseases associated with PSMB9 include Proteasome-Associated Autoinflammatory Syndrome 3 and Nasopharyngeal Disease. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Antigen processing-Cross presentation. Gene Ontology (GO) annotations related to this gene include threonine-type endopeptidase activity. An important paralog of this gene is PSMB6.
UniProtKB/Swiss-Prot Summary for PSMB9 Gene
-
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues.
Additional gene information for PSMB9 Gene
- HGNC(9546)
- Entrez Gene(5698)
- Ensembl(ENSG00000240065)
- OMIM(177045)
- UniProtKB(P28065)
- Open Targets Platform(ENSG00000240065)
- Search for PSMB9 at DataMed
- Search for PSMB9 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSMB9 Gene
Genomics for PSMB9 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PSMB9 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PSMB9 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PSMB9
- Top Transcription factor binding sites by QIAGEN in the PSMB9 gene promoter:
-
- AML1a
- STAT3
Genomic Locations for PSMB9 Gene
Genomic Locations for PSMB9 Gene
- chr6:32,844,136-32,859,851
- (GRCh38/hg38)
- Size:
- 15,716 bases
- Orientation:
- Plus strand
- chr6:32,811,913-32,827,628
- (GRCh37/hg19)
- Size:
- 15,716 bases
- Orientation:
- Plus strand
Genomic View for PSMB9 Gene
Genes around PSMB9 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p21.32 by HGNC
- 6p21.32 by Entrez Gene
- 6p21.32 by Ensembl
PSMB9 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PSMB9 Gene
Proteins for PSMB9 Gene
-
Protein details for PSMB9 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P28065-PSB9_HUMAN
- Recommended name:
- Proteasome subunit beta type-9
- Protein Accession:
- P28065
- B0V0T1
- Q16523
- Q5JNW4
Protein attributes for PSMB9 Gene
- Size:
- 219 amino acids
- Molecular mass:
- 23264 Da
- Quaternary structure:
-
- The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Component of the immunoproteasome, where it displaces the equivalent housekeeping subunit PSMB6. Component of the spermatoproteasome, a form of the proteasome specifically found in testis.
- (Microbial infection) Interacts with HIV-1 TAT protein.
- Miscellaneous:
-
- Encoded in the MHC class II region.
- A model for self-activation in which residue Thr-21 serves as nucleophile and Lys-53 as proton donor/acceptor has been proposed. Subunit processing of mammalian beta-subunits proceeds via a novel ordered two-step mechanism involving autocatalysis.
Protein Expression for PSMB9 Gene
Selected DME Specific Peptides for PSMB9 Gene
- P28065:
-
- AVVNRVFDKLSPLH
- QPFAIGGSGS
- VAGWDQREGGQVYGT
- GSDSRVSAG
- TGTTIMAV
- ADMAAYQLELHG
- RDGSSGGV
- IYGYVDAAYKPGM
- YKYREDL
- CALSGSAADAQ
Post-translational modifications for PSMB9 Gene
- Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile proteolytic activity.
-
Ubiquitination at Lys53 and Lys215
- NX_P28065 (NX_P28065-1)
- Modification sites at PhosphoSitePlus
Other Protein References for PSMB9 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences PSMB9 Monoclonal Antibody
- G Biosciences Immunotag™ PSMB9 Antibody
-
Custom Antibody ServicesOriGene Antibodies for PSMB9
- Novus Biologicals Antibodies for PSMB9
-
Abcam antibodies for PSMB9
- Invitrogen Antibodies for PSMB9 (AFLGC-Psmb9)
-
Santa Cruz Biotechnology (SCBT) Antibodies for PSMB9
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for PSMB9
- Origene Custom Protein Services for PSMB9
- ProSpec Recombinant Proteins for PSMB9
-
Signalway Proteins for PSMB9
-
Abcam proteins for PSMB9
Assay Products
Domains & Families for PSMB9 Gene
Gene Families for PSMB9 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- FDA approved drug targets
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for PSMB9 Gene
- InterPro:
- Blocks:
-
- Proteasome B-type subunit
- ProtoNet:
Suggested Antigen Peptide Sequences for PSMB9 Gene
- GenScript: Design optimal peptide antigens:
-
- Proteasome subunit beta type (A2ACR1_HUMAN)
- Proteasome subunit beta type (B0V0T3_HUMAN)
- cDNA FLJ54210, moderately similar to Proteasome subunit beta type 9 (EC 3.4.25.1) (B4DZW2_HUMAN)
- Really interesting new gene 12 protein (PSB9_HUMAN)
- Proteasome subunit beta type (Q5JNW4_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P28065- Family:
-
- Belongs to the peptidase T1B family.
Function for PSMB9 Gene
Molecular function for PSMB9 Gene
- UniProtKB/Swiss-Prot Function:
- The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=Cleavage of peptide bonds with very broad specificity.; EC=3.4.25.1;.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated by interferon gamma (at protein level). Up-regulated by IRF1. Up-regulated by tumor necrosis factor-alpha (at protein level). Up-regulated by tetrodotoxin (TTX) in glial cells. Up-regulated in Crohn's bowel disease (CD). Up-regulated by heat shock treatment. Up-regulated by CD40L via the NFKB1 pathway in cancer cells.
- GENATLAS Biochemistry:
- multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component 2,beta-type subunit 2,stimulated by interferon gamma,involved in the degradation of cytoplasmic antigens for MHC class I antigen presentation pathways
Enzyme Numbers (IUBMB) for PSMB9 Gene
Phenotypes From GWAS Catalog for PSMB9 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004175 | endopeptidase activity | IBA | 21873635 |
| GO:0004298 | threonine-type endopeptidase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 14733938 |
| GO:0008233 | peptidase activity | IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for PSMB9 Gene
- MGI mutant phenotypes for PSMB9:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for PSMB9:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Increased IL-8 secretion
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased transferrin (TF) endocytosis
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Increased HPV18 LCR reporter activity
- Increased hepcidin::fluc mRNA expression
- Increased viability with MLN4924 (a NAE inhibitor)
Animal Models for PSMB9 Gene
- MGI Knock Outs for PSMB9:
-
- Psmb9/Psmb8 Psmb9/Psmb8<tm1Klr>
- Psmb9 Psmb9<tm1Stl>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PSMB9 - Select products 50% OFF >
- * PSMB9 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PSMB9
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PSMB9
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSMB9
miRNA for PSMB9 Gene
- miRTarBase miRNAs that target PSMB9
-
- hsa-miR-129-5p (MIRT508787)
- hsa-miR-659-3p (MIRT508788)
- hsa-miR-1257 (MIRT508789)
- hsa-miR-29b-2-5p (MIRT508790)
- hsa-miR-193b-5p (MIRT508791)
- hsa-miR-6798-5p (MIRT508792)
- hsa-miR-6732-5p (MIRT508793)
- hsa-miR-498 (MIRT683895)
- hsa-miR-6836-3p (MIRT683896)
- hsa-miR-5001-3p (MIRT683897)
- hsa-miR-6783-3p (MIRT683898)
- hsa-miR-1343-3p (MIRT683899)
- hsa-miR-23b-5p (MIRT683900)
- hsa-miR-23a-5p (MIRT683901)
- hsa-miR-6829-3p (MIRT683902)
- hsa-miR-6791-3p (MIRT683903)
- hsa-miR-6778-3p (MIRT683904)
- hsa-miR-4772-3p (MIRT683905)
- hsa-miR-6787-3p (MIRT683906)
- hsa-miR-1304-3p (MIRT683907)
- hsa-miR-6742-3p (MIRT683908)
- hsa-miR-6852-5p (MIRT683909)
- hsa-miR-939-3p (MIRT683910)
- hsa-miR-660-3p (MIRT683911)
- hsa-miR-6736-3p (MIRT683912)
- hsa-miR-6890-3p (MIRT683913)
- hsa-miR-216a-5p (MIRT683914)
- hsa-miR-1267 (MIRT783265)
- hsa-miR-200c-5p (MIRT784129)
- hsa-miR-208a-3p (MIRT784156)
- hsa-miR-208b-3p (MIRT784163)
- hsa-miR-3617-5p (MIRT784973)
- hsa-miR-3658 (MIRT785045)
- hsa-miR-3664-5p (MIRT785089)
- hsa-miR-367-5p (MIRT785200)
- hsa-miR-4711-3p (MIRT786501)
- hsa-miR-4714-5p (MIRT786509)
- hsa-miR-499a-5p (MIRT786922)
- hsa-miR-514a-5p (MIRT787169)
- hsa-miR-550a-3p (MIRT787608)
- hsa-miR-550b-3p (MIRT787613)
- hsa-miR-641 (MIRT788175)
- hsa-miR-6733-3p (MIRT788491)
- hsa-miR-7856-5p (MIRT789617)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PSMB9
- Browse OriGene Inhibitory RNA Products For PSMB9
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMB9
Clone Products
- Applied Biological Materials (abm): Clones for PSMB9 - Select products 50% OFF >
- * PSMB9 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PSMB9
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PSMB9
No data available for Transcription Factor Targets and HOMER Transcription for PSMB9 Gene
Localization for PSMB9 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PSMB9 Gene
- Cytoplasm. Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 4 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000502 | proteasome complex | TAS | 8666937 |
| GO:0005634 | nucleus | IBA | 21873635 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IBA | 21873635 |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for PSMB9 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of activated PAK-2p34 by proteasome mediated degradation |
.93
.93
|
.80
.79
.78
.69
.47
|
| 2 | RET signaling |
.92
|
.92
|
| 3 | Chks in Checkpoint Regulation |
Chks in Checkpoint Regulation
.58
G2-M Phase Transition
.58
Estrogen-mediated S-Phase Entry
.54
|
SREBP Proteolysis
.42
DNA Repair Mechanisms
.31
|
| 4 | HIV Life Cycle |
.65
|
.45
|
| 5 | Class I MHC mediated antigen processing and presentation | ||
Pathways by source for PSMB9 Gene
2 BioSystems pathways for PSMB9 Gene
164 Reactome pathways for PSMB9 Gene
1 KEGG pathway for PSMB9 Gene
1 GeneGo (Thomson Reuters) pathway for PSMB9 Gene
- Immune response Antigen presentation by MHC class I
12 Qiagen pathways for PSMB9 Gene
- CDK5 Pathway
- Chks in Checkpoint Regulation
- DNA Repair Mechanisms
- Estrogen-mediated S-Phase Entry
- G2-M Phase Transition
Interacting Proteins for PSMB9 Gene
Selected Interacting proteins:
P28065-PSB9_HUMAN
ENSP00000363993
for PSMB9 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for PSMB9
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
No data available for SIGNOR curated interactions for PSMB9 Gene
Drugs & Compounds for PSMB9 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| carfilzomib | Approved, Investigational | Pharma | Target, inhibitor, other | Other, 20S Proteasome Inhibitor | 0 | |
| Bortezomib | Approved, Investigational | Pharma | inhibitor, other | Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors | 910 | |
| Celastrol | Pharma | Antioxidant, anti-inflammatory and immunosuppressive agent | 0 | |||
| Dihydroeponemycin | Pharma | Proteasome inhibitor,antitumor reagent,eponemycin ddrivative | 0 | |||
| MLN2238 | Pharma | β5 site of the 20S proteasome inhibitor | 0 |
(4) ApexBio Compounds for PSMB9 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Celastrol | Antioxidant, anti-inflammatory and immunosuppressive agent | 34157-83-0 |
| Dihydroeponemycin | Proteasome inhibitor,antitumor reagent,eponemycin ddrivative | 126463-64-7 |
| MLN2238 | β5 site of the 20S proteasome inhibitor | 1072833-77-2 |
| ONX-0914 (PR-957) | Immunoproteasome inhibitor,potent and selective | 960374-59-8 |
Transcripts for PSMB9 Gene
mRNA/cDNA for PSMB9 Gene
- 2 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000374859 1017 nts (view in UCSC)
- ENST00000395330 792 nts (view in UCSC)
- ENST00000414474 439 nts (view in UCSC)
- ENST00000464863 2676 nts (view in UCSC)
- ENST00000467593 730 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PSMB9 - Select products 50% OFF >
- * PSMB9 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PSMB9
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PSMB9
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSMB9
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PSMB9
- Browse OriGene Inhibitory RNA Products For PSMB9
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMB9
Clone Products
- Applied Biological Materials (abm): Clones for PSMB9 - Select products 50% OFF >
- * PSMB9 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PSMB9
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PSMB9
Relevant External Links for PSMB9 Gene
- GeneLoc Exon Structure for
- PSMB9
Expression for PSMB9 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Endothelial Cells Blood Brain Barrier
- Adult Endothelial Cells Blood Brain Barrier
-
Endothelium (Cardiovascular System)
- Endothelial Cells Blood Brain Barrier
- Adult Endothelial Cells Blood Brain Barrier
-
Ovary (Reproductive System)
- Mature Granulosa Cells Antral Follicle
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
- Lateral Plate Mesoderm (Gastrulation Derivatives)
- Neural Crest (Gastrulation Derivatives)
-
Spleen (Hematopoietic System)
-
Heart (Cardiovascular System)
mRNA differential expression in normal tissues according to GTEx for PSMB9 Gene
This gene is overexpressed in Whole Blood (x10.6) and Spleen (x4.2).
This gene is overexpressed in Tlymphocyte (19.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMB9 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PSMB9
SOURCE GeneReport for Unigene cluster for PSMB9 Gene:
Hs.654585Evidence on tissue expression from TISSUES for PSMB9 Gene
- Pancreas(4.4)
- Blood(3.5)
- Spleen(3)
- Lymph node(2.7)
- Heart(2.4)
- Liver(2.4)
- Nervous system(2.3)
- Intestine(2.2)
- Kidney(2.2)
- Skin(2.1)
- Lung(2)
Primer Products
-
OriGene qPCR primer pairs for PSMB9
-
OriGene qPCR primer pairs and template standards for PSMB9
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMB9 Gene
Orthologs for PSMB9 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PSMB9 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PSMB9 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PSMB9 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Psmb9 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Psmb9 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | PSMB9 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | PSMB9 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | psmb9 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | psmb9a 30 31 |
|
OneToOne | |
| -- 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.11923 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Prosbeta1 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | pbs-1 31 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PRE3 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.5051 31 |
|
OneToMany |
- Species where no ortholog for PSMB9 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for PSMB9 Gene
- ENSEMBL:
- Gene Tree for PSMB9 (if available)
- TreeFam:
- Gene Tree for PSMB9 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PSMB9: view image
Paralogs for PSMB9 Gene
Paralogs for PSMB9 Gene
(4) SIMAP similar genes for PSMB9 Gene using alignment to 5 proteins:
- PSB9_HUMAN
- A2ACQ9_HUMAN
- A2ACR0_HUMAN
- A2ACR1_HUMAN
- B4DZW2_HUMAN
Variants for PSMB9 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PSMB9 Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 756788 | Likely Benign: not provided | 32,856,170(+) | C/T | SYNONYMOUS_VARIANT | |
| rs367733308 | Uncertain Significance: not provided | 32,858,075(+) | C/A | SYNONYMOUS_VARIANT | |
| rs369359789 | Pathogenic: PROTEASOME-ASSOCIATED AUTOINFLAMMATORY SYNDROME 3. Proteasome-associated autoinflammatory syndrome 3 (PRAAS3) [MIM:617591] | 32,858,467(+) | G/Ap.Gly165Asp | MISSENSE_VARIANT | |
| rs17213861 | - | p.Arg173Cys | |||
| rs17587 | - | p.Arg60His |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1073969 | CNV | deletion | 25765185 |
| nsv1112900 | CNV | deletion | 24896259 |
| nsv1119076 | CNV | deletion | 24896259 |
| nsv830633 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
76.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.62;
82.71% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PSMB9 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMB9 Gene
Disorders for PSMB9 Gene
(21) MalaCards diseases for PSMB9 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| proteasome-associated autoinflammatory syndrome 3 |
|