The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiq... See more...

Aliases for PSMB9 Gene

Aliases for PSMB9 Gene

  • Proteasome 20S Subunit Beta 9 2 3
  • Proteasome Subunit Beta 9 2 3 5
  • Multicatalytic Endopeptidase Complex Chain 7 3 4
  • Really Interesting New Gene 12 Protein 3 4
  • Large Multifunctional Peptidase 2 2 3
  • Proteasome Subunit Beta Type-9 3 4
  • Low Molecular Mass Protein 2 3 4
  • Proteasome Subunit Beta-1i 3 4
  • Proteasome Chain 7 3 4
  • Macropain Chain 7 3 4
  • EC 3.4.25.1 4 52
  • PSMB6i 3 4
  • RING12 3 4
  • LMP2 3 4
  • Proteasome (Prosome, Macropain) Subunit, Beta Type, 9 (Large Multifunctional Peptidase 2) 3
  • Proteasome (Prosome, Macropain) Subunit, Beta Type, 9 (Large Multifunctional Protease 2) 2
  • Proteasome (Prosome, Macropain) Subunit, Beta Type, 9 2
  • Proteasome Catalytic Subunit 1i 3
  • Proteasome Subunit Beta 6i 3
  • Proteasome Subunit Beta1i 3
  • Proteasome-Related Gene 2 3
  • Proteasome Subunit Β1i 2
  • PRAAS3 3
  • Beta1i 3

External Ids for PSMB9 Gene

Previous HGNC Symbols for PSMB9 Gene

  • LMP2

Previous GeneCards Identifiers for PSMB9 Gene

  • GC06P032818
  • GC06P032582
  • GC06P032868
  • GC06P032929
  • GC06P032812
  • GC06P032815
  • GC06P032821
  • GC06P032825
  • GC06P032845
  • GC06P032977

Summaries for PSMB9 Gene

Entrez Gene Summary for PSMB9 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 1 (proteasome beta 6 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. [provided by RefSeq, Mar 2010]

GeneCards Summary for PSMB9 Gene

PSMB9 (Proteasome 20S Subunit Beta 9) is a Protein Coding gene. Diseases associated with PSMB9 include Proteasome-Associated Autoinflammatory Syndrome 3 and Nasopharyngeal Disease. Among its related pathways are Metabolism of proteins and RET signaling. Gene Ontology (GO) annotations related to this gene include threonine-type endopeptidase activity. An important paralog of this gene is PSMB6.

UniProtKB/Swiss-Prot Summary for PSMB9 Gene

  • The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues.

Gene Wiki entry for PSMB9 Gene

Additional gene information for PSMB9 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSMB9 Gene

Genomics for PSMB9 Gene

GeneHancer (GH) Regulatory Elements for PSMB9 Gene

Promoters and enhancers for PSMB9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J032837 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 517.3 -1.9 -1897 9.8 RXRA ZBTB40 ZNF217 CTCF ZSCAN5C SIN3A POLR2G SP1 ZNF639 ZNF10 PSMB9 PSMB8-AS1 PSMB8 TAP2 HLA-DMA TAP1 HLA-DRB1 HLA-DOB HLA-DQA1 ENSG00000250264
GH06J032851 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 533.1 +9.8 9770 5.2 ZNF217 CTCF SIN3A NRF1 POLR2G NCOR1 PHF8 ZFX ZIC2 REST PSMB9 TAP1 PSMB8 HLA-DOB C4A BRD2 TAP2 SKIV2L PSMB8-AS1 HLA-DQA1
GH06J032866 Enhancer 1.1 FANTOM5 Ensembl ENCODE 31.2 +22.9 22894 3.3 RXRA CTCF GTF2E2 ZNF10 REST ZBTB25 RAD21 TRIM22 POLR2A ZKSCAN8 HSALNG0049456 PSMB9 HLA-DOB HLA-DQA1 PSMB8-AS1 PSMB8 TAP1 TAP2 BRD2 lnc-PSMB9-13
GH06J032860 Enhancer 1.1 Ensembl ENCODE dbSUPER 30.3 +17.2 17165 1.4 ZNF217 CTCF NRF1 TEAD4 RELA TEAD1 CTBP1 POLR2A SIN3A NFIC PSMB9 TAP1 HLA-DQB1 HLA-DQA1 HSALNG0049456
GH06J032893 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 20.3 +50.5 50465 2.8 ZNF217 EP300 USF1 POLR2G SP1 PHF8 ZFX ZIC2 POLR2A ZBTB10 HLA-Z lnc-TAP1-1 PSMB9 HLA-DMA ATF6B BRD2 ITPR3 LEMD2 DAXX RGL2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSMB9 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PSMB9

Top Transcription factor binding sites by QIAGEN in the PSMB9 gene promoter:
  • AML1a
  • STAT3

Genomic Locations for PSMB9 Gene

Genomic Locations for PSMB9 Gene
chr6:32,844,136-32,859,851
(GRCh38/hg38)
Size:
15,716 bases
Orientation:
Plus strand
chr6:32,811,913-32,827,628
(GRCh37/hg19)
Size:
15,716 bases
Orientation:
Plus strand

Genomic View for PSMB9 Gene

Genes around PSMB9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMB9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMB9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for PSMB9 Gene

  • Protein details for PSMB9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28065-PSB9_HUMAN
    Recommended name:
    Proteasome subunit beta type-9
    Protein Accession:
    P28065
    Secondary Accessions:
    • B0V0T1
    • Q16523
    • Q5JNW4

    Protein attributes for PSMB9 Gene

    Size:
    219 amino acids
    Molecular mass:
    23264 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Component of the immunoproteasome, where it displaces the equivalent housekeeping subunit PSMB6. Component of the spermatoproteasome, a form of the proteasome specifically found in testis.
    • (Microbial infection) Interacts with HIV-1 TAT protein.
    Miscellaneous:
    • Encoded in the MHC class II region.
    • A model for self-activation in which residue Thr-21 serves as nucleophile and Lys-53 as proton donor/acceptor has been proposed. Subunit processing of mammalian beta-subunits proceeds via a novel ordered two-step mechanism involving autocatalysis.

    Three dimensional structures from OCA and Proteopedia for PSMB9 Gene

    Alternative splice isoforms for PSMB9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMB9 Gene

Selected DME Specific Peptides for PSMB9 Gene

P28065:
  • AVVNRVFDKLSPLH
  • QPFAIGGSGS
  • VAGWDQREGGQVYGT
  • GSDSRVSAG
  • TGTTIMAV
  • ADMAAYQLELHG
  • RDGSSGGV
  • IYGYVDAAYKPGM
  • YKYREDL
  • CALSGSAADAQ

Post-translational modifications for PSMB9 Gene

  • Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile proteolytic activity.
  • Ubiquitination at Lys53 and Lys215
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMB9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PSMB9 Gene

Gene Families for PSMB9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PSMB9 Gene

Suggested Antigen Peptide Sequences for PSMB9 Gene

GenScript: Design optimal peptide antigens:
  • Proteasome subunit beta type (A2ACR1_HUMAN)
  • Proteasome subunit beta type (B0V0T3_HUMAN)
  • cDNA FLJ54210, moderately similar to Proteasome subunit beta type 9 (EC 3.4.25.1) (B4DZW2_HUMAN)
  • Really interesting new gene 12 protein (PSB9_HUMAN)
  • Proteasome subunit beta type (Q5JNW4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P28065

UniProtKB/Swiss-Prot:

PSB9_HUMAN :
  • Belongs to the peptidase T1B family.
Family:
  • Belongs to the peptidase T1B family.
genes like me logo Genes that share domains with PSMB9: view

Function for PSMB9 Gene

Molecular function for PSMB9 Gene

UniProtKB/Swiss-Prot Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Cleavage of peptide bonds with very broad specificity.; EC=3.4.25.1;.
UniProtKB/Swiss-Prot Induction:
Up-regulated by interferon gamma (at protein level). Up-regulated by IRF1. Up-regulated by tumor necrosis factor-alpha (at protein level). Up-regulated by tetrodotoxin (TTX) in glial cells. Up-regulated in Crohn's bowel disease (CD). Up-regulated by heat shock treatment. Up-regulated by CD40L via the NFKB1 pathway in cancer cells.
GENATLAS Biochemistry:
multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component 2,beta-type subunit 2,stimulated by interferon gamma,involved in the degradation of cytoplasmic antigens for MHC class I antigen presentation pathways

Enzyme Numbers (IUBMB) for PSMB9 Gene

Phenotypes From GWAS Catalog for PSMB9 Gene

Gene Ontology (GO) - Molecular Function for PSMB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IBA 21873635
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 14733938
GO:0008233 peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PSMB9: view
genes like me logo Genes that share phenotypes with PSMB9: view

Human Phenotype Ontology for PSMB9 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PSMB9 Gene

MGI Knock Outs for PSMB9:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMB9

Clone Products

No data available for Transcription Factor Targets and HOMER Transcription for PSMB9 Gene

Localization for PSMB9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMB9 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMB9 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
lysosome 2
peroxisome 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PSMB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex TAS 8666937
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PSMB9: view

Pathways & Interactions for PSMB9 Gene

PathCards logo

SuperPathways for PSMB9 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 Chks in Checkpoint Regulation
.59
.59
.55
.43
.32
4 HIV Life Cycle
.45
5 Class I MHC mediated antigen processing and presentation
genes like me logo Genes that share pathways with PSMB9: view

Pathways by source for PSMB9 Gene

1 GeneGo (Thomson Reuters) pathway for PSMB9 Gene
  • Immune response Antigen presentation by MHC class I
12 Qiagen pathways for PSMB9 Gene
  • CDK5 Pathway
  • Chks in Checkpoint Regulation
  • DNA Repair Mechanisms
  • Estrogen-mediated S-Phase Entry
  • G2-M Phase Transition

Gene Ontology (GO) - Biological Process for PSMB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002376 immune system process IEA --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
genes like me logo Genes that share ontologies with PSMB9: view

No data available for SIGNOR curated interactions for PSMB9 Gene

Drugs & Compounds for PSMB9 Gene

(6) Drugs for PSMB9 Gene - From: DrugBank, ApexBio, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
carfilzomib Approved, Investigational Pharma Target, inhibitor, other Other, 20S Proteasome Inhibitor 0
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 888
Celastrol Pharma Antioxidant, anti-inflammatory and immunosuppressive agent 0
Dihydroeponemycin Pharma Proteasome inhibitor,antitumor reagent,eponemycin ddrivative 0
MLN2238 Pharma β5 site of the 20S proteasome inhibitor 0

(4) ApexBio Compounds for PSMB9 Gene

Compound Action Cas Number
Celastrol Antioxidant, anti-inflammatory and immunosuppressive agent 34157-83-0
Dihydroeponemycin Proteasome inhibitor,antitumor reagent,eponemycin ddrivative 126463-64-7
MLN2238 β5 site of the 20S proteasome inhibitor 1072833-77-2
ONX-0914 (PR-957) Immunoproteasome inhibitor,potent and selective 960374-59-8
genes like me logo Genes that share compounds with PSMB9: view

Drug Products

Transcripts for PSMB9 Gene

mRNA/cDNA for PSMB9 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMB9

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMB9 Gene

No ASD Table

Relevant External Links for PSMB9 Gene

GeneLoc Exon Structure for
PSMB9

Expression for PSMB9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PSMB9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PSMB9 Gene

This gene is overexpressed in Whole Blood (x10.6) and Spleen (x4.2).

Protein differential expression in normal tissues from HIPED for PSMB9 Gene

This gene is overexpressed in Tlymphocyte (19.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMB9 Gene



Protein tissue co-expression partners for PSMB9 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PSMB9

SOURCE GeneReport for Unigene cluster for PSMB9 Gene:

Hs.654585

Evidence on tissue expression from TISSUES for PSMB9 Gene

  • Pancreas(4.1)
  • Blood(3.1)
  • Spleen(2.5)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with PSMB9: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMB9 Gene

Orthologs for PSMB9 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PSMB9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMB9 31 30
  • 99.08 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PSMB9 31 30
  • 87.6 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PSMB9 31 30
  • 87.21 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psmb9 30
  • 84.78 (n)
mouse
(Mus musculus)
Mammalia Psmb9 17 31 30
  • 84.47 (n)
oppossum
(Monodelphis domestica)
Mammalia PSMB9 31
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSMB9 31
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psmb9 30
  • 67 (n)
zebrafish
(Danio rerio)
Actinopterygii psmb9a 31 30
  • 66.99 (n)
OneToOne
-- 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11923 30
fruit fly
(Drosophila melanogaster)
Insecta Prosbeta1 31
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pbs-1 31
  • 36 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRE3 31
  • 43 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5051 31
  • 56 (a)
OneToMany
Species where no ortholog for PSMB9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSMB9 Gene

ENSEMBL:
Gene Tree for PSMB9 (if available)
TreeFam:
Gene Tree for PSMB9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PSMB9: view image

Paralogs for PSMB9 Gene

(4) SIMAP similar genes for PSMB9 Gene using alignment to 5 proteins:

  • PSB9_HUMAN
  • A2ACQ9_HUMAN
  • A2ACR0_HUMAN
  • A2ACR1_HUMAN
  • B4DZW2_HUMAN
genes like me logo Genes that share paralogs with PSMB9: view

Variants for PSMB9 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PSMB9 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
756788 Likely Benign: not provided 32,856,170(+)