PSMB9 Gene (Protein Coding)

Proteasome 20S Subunit Beta 9

GCID:: GC06P033443

GIFtS:: 47

Genes Participants

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiq... See more...

Aliases for PSMB9 Gene

Proteasome 20S Subunit Beta 9 ² ³
Proteasome Subunit Beta 9 ² ³ ⁵
Multicatalytic Endopeptidase Complex Chain 7 ³ ⁴
Really Interesting New Gene 12 Protein ³ ⁴
Large Multifunctional Peptidase 2 ² ³
Proteasome Subunit Beta Type-9 ³ ⁴
Low Molecular Mass Protein 2 ³ ⁴
Proteasome Subunit Beta-1i ³ ⁴
Proteasome Chain 7 ³ ⁴
Macropain Chain 7 ³ ⁴
EC 3.4.25.1 ⁴ ⁵²
PSMB6i ³ ⁴

RING12 ³ ⁴
LMP2 ³ ⁴
Proteasome (Prosome, Macropain) Subunit, Beta Type, 9 (Large Multifunctional Peptidase 2) ³
Proteasome (Prosome, Macropain) Subunit, Beta Type, 9 (Large Multifunctional Protease 2) ²
Proteasome (Prosome, Macropain) Subunit, Beta Type, 9 ²
Proteasome Catalytic Subunit 1i ³
Proteasome Subunit Beta 6i ³
Proteasome Subunit Beta1i ³
Proteasome-Related Gene 2 ³
Proteasome Subunit Β1i ²
PRAAS3 ³
Beta1i ³

External Ids for PSMB9 Gene

HGNC: 9546
Entrez Gene: 5698
Ensembl: ENSG00000240065
OMIM: 177045
UniProtKB: P28065

Previous HGNC Symbols for PSMB9 Gene

LMP2

Previous GeneCards Identifiers for PSMB9 Gene

GC06P032818
GC06P032582
GC06P032868
GC06P032929
GC06P032812
GC06P032815
GC06P032821
GC06P032825
GC06P032845
GC06P032977

Search aliases for PSMB9 gene in PubMed and other databases

Summaries for PSMB9 Gene

Entrez Gene Summary for PSMB9 Gene

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 1 (proteasome beta 6 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. [provided by RefSeq, Mar 2010]

GeneCards Summary for PSMB9 Gene

PSMB9 (Proteasome 20S Subunit Beta 9) is a Protein Coding gene. Diseases associated with PSMB9 include Proteasome-Associated Autoinflammatory Syndrome 3 and Nasopharyngeal Disease. Among its related pathways are Metabolism of proteins and RET signaling. Gene Ontology (GO) annotations related to this gene include threonine-type endopeptidase activity. An important paralog of this gene is PSMB6.

UniProtKB/Swiss-Prot Summary for PSMB9 Gene

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues.
- PSB9_HUMAN,P28065

Gene Wiki entry for PSMB9 Gene

Additional gene information for PSMB9 Gene

Search for PSMB9 at DataMed
Search for PSMB9 at HumanCyc

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSMB9 Gene

Genomics for PSMB9 Gene

GeneHancer (GH) Regulatory Elements for PSMB9 Gene

Promoters and enhancers for PSMB9 Gene

GeneHancer (GH) Identifier	GH Type	GH Score	GH Sources	Gene Association Score	Total Score	TSS distance (kb)	Number of Genes Away	Size (kb)	Transcription Factor Binding Sites
GH06J032837	Promoter/Enhancer	2.2	EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER	517.3	-1.9	-1897	9.8	RXRA ZBTB40 ZNF217 CTCF ZSCAN5C SIN3A POLR2G SP1 ZNF639 ZNF10	PSMB9 PSMB8-AS1 PSMB8 TAP2 HLA-DMA TAP1 HLA-DRB1 HLA-DOB HLA-DQA1 ENSG00000250264
GH06J032851	Promoter/Enhancer	2.1	EPDnew FANTOM5 Ensembl ENCODE dbSUPER	533.1	+9.8	9770	5.2	ZNF217 CTCF SIN3A NRF1 POLR2G NCOR1 PHF8 ZFX ZIC2 REST	PSMB9 TAP1 PSMB8 HLA-DOB C4A BRD2 TAP2 SKIV2L PSMB8-AS1 HLA-DQA1
GH06J032866	Enhancer	1.1	FANTOM5 Ensembl ENCODE	31.2	+22.9	22894	3.3	RXRA CTCF GTF2E2 ZNF10 REST ZBTB25 RAD21 TRIM22 POLR2A ZKSCAN8	HSALNG0049456 PSMB9 HLA-DOB HLA-DQA1 PSMB8-AS1 PSMB8 TAP1 TAP2 BRD2 lnc-PSMB9-13
GH06J032860	Enhancer	1.1	Ensembl ENCODE dbSUPER	30.3	+17.2	17165	1.4	ZNF217 CTCF NRF1 TEAD4 RELA TEAD1 CTBP1 POLR2A SIN3A NFIC	PSMB9 TAP1 HLA-DQB1 HLA-DQA1 HSALNG0049456
GH06J032893	Promoter/Enhancer	1.7	Ensembl ENCODE CraniofacialAtlas	20.3	+50.5	50465	2.8	ZNF217 EP300 USF1 POLR2G SP1 PHF8 ZFX ZIC2 POLR2A ZBTB10	HLA-Z lnc-TAP1-1 PSMB9 HLA-DMA ATF6B BRD2 ITPR3 LEMD2 DAXX RGL2

- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSMB9 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PSMB9

Top Transcription factor binding sites by QIAGEN in the PSMB9 gene promoter:

AML1a
STAT3

Genomic Locations for PSMB9 Gene

chr6:32,844,136-32,859,851: (GRCh38/hg38)

Size:: 15,716 bases
Orientation:: Plus strand

chr6:32,811,913-32,827,628: (GRCh37/hg19)

Size:: 15,716 bases
Orientation:: Plus strand

Genomic View for PSMB9 Gene

Genes around PSMB9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:

6p21.32 by HGNC
6p21.32 by Entrez Gene
6p21.32 by Ensembl

PSMB9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

Genomic Location for PSMB9 Gene — Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PSMB9 Gene

Proteins for PSMB9 Gene

Protein details for PSMB9 Gene (UniProtKB/Swiss-Prot)
Protein Symbol:

P28065-PSB9_HUMAN

Recommended name:

Proteasome subunit beta type-9

Protein Accession:

P28065

Secondary Accessions:
- B0V0T1
- Q16523
- Q5JNW4
Protein attributes for PSMB9 Gene
Size:

219 amino acids

Molecular mass:

23264 Da
Quaternary structure:
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Component of the immunoproteasome, where it displaces the equivalent housekeeping subunit PSMB6. Component of the spermatoproteasome, a form of the proteasome specifically found in testis.

(Microbial infection) Interacts with HIV-1 TAT protein.
Miscellaneous:
Encoded in the MHC class II region.

A model for self-activation in which residue Thr-21 serves as nucleophile and Lys-53 as proton donor/acceptor has been proposed. Subunit processing of mammalian beta-subunits proceeds via a novel ordered two-step mechanism involving autocatalysis.
Three dimensional structures from OCA and Proteopedia for PSMB9 Gene
- 6AVO (3D)
- 6E5B (3D)
Alternative splice isoforms for PSMB9 Gene
UniProtKB/Swiss-Prot:
P28065-1

P28065-2

neXtProt entry for PSMB9 Gene

Protein Expression for PSMB9 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for PSMB9 Gene

P28065:

AVVNRVFDKLSPLH
QPFAIGGSGS
VAGWDQREGGQVYGT
GSDSRVSAG
TGTTIMAV
ADMAAYQLELHG
RDGSSGGV
IYGYVDAAYKPGM
YKYREDL
CALSGSAADAQ

Post-translational modifications for PSMB9 Gene

Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile proteolytic activity.
- P28065-PSB9_HUMAN
Ubiquitination at Lys53 and Lys215
- NX_P28065 (NX_P28065-1)
Modification sites at PhosphoSitePlus
- P28065

Other Protein References for PSMB9 Gene

ENSEMBL proteins:

REFSEQ proteins:

NP_002791.1

Antibody Products

G Biosciences Immunotag™ PSMB9 Antibody

Creative Diagnostics Anti-PSMB9 monoclonal antibody, clone FQS24896

Creative Biolabs Recombinant Anti-Human PSMB9 Antibody and Mouse Anti-PSMB9 Recombinant Antibody (1F10)

Human LMP2/PSMB9 Antibody (MAB7709)

OriGene Antibodies for PSMB9
- AP18163PU-N
- AP22385PU-N
- CF504348
- CF504349
- CF504350
- CF504388
- CF504389
- CF504390
- CF504391
- CF504392
- TA322957
- TA327172
- TA504348
- TA504348S
- TA504349
- TA504349S
- TA504350
- TA504350S
- TA504388
- TA504388S
- TA504389
- TA504389S
- TA504390
- TA504390S
- TA504391
- TA504391S
- TA504392
- TA504392S
Custom Antibody Services

Novus Biologicals Antibodies for PSMB9

Abcam antibodies for PSMB9
- Proteasome 20S LMP2

Invitrogen Antibodies for PSMB9 (AFLGC-PSMB9)

Biorbyt antibodies for PSMB9
- orb136178
- orb340778
- orb485127
- orb8424

Boster Bio Antibodies for PSMB9
- M02867

Santa Cruz Biotechnology (SCBT) Antibodies for PSMB9

Browse Sino Biological Antibodies

Protein Products

Creative Biomart Recombinant Human PSMB9, His-tagged

OriGene Purified Proteins for PSMB9
- NM_002800
- NM_148954
- NM_002800
- NM_148954
- NM_148954
- NM_002800
- NM_148954
- NM_002800
- NM_002800
- NM_002800
- NM_013585
Search Origene for MassSpec and Protein Over-expression Lysates for PSMB9
Origene Custom Protein Services for PSMB9

Novus Biologicals proteins and lysates for PSMB9

ProSpec Recombinant Proteins for PSMB9

antibodies-online: Show 14 available PSMB9 Proteins ranked by validation data
Compare Top PSMB9 Proteins

Signalway Proteins for PSMB9
- AP79817

Search for PSMB9 Proteins at ProSci

Abcam proteins for PSMB9
- Proteasome 20S LMP2

Assay Products

G Biosciences Immunotag™ Human PSMB9 (Proteasome subunit beta type-9) ELISA and Immunotag™ Proteasome subunit beta type-9 ELISA Kit

Aviva Systems Biology PSMB9 ELISA Kit (Human) (OKEH04653) and PSMB9 ELISA Kit (Human) (OKCD06246)

antibodies-online: Show 14 available PSMB9 Elisa Kits ranked by validation data
Compare Top PSMB9 Elisa Kits
Quality Products:

Browse Boster Bio ELISA Kits

Signalway ELISA kits for PSMB9
- EK8046
- EK15260

Browse Sino Biological Assays

Domains & Families for PSMB9 Gene

Gene Families for PSMB9 Gene

HGNC:

Proteasome

Human Protein Atlas (HPA):

Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Protein Domains for PSMB9 Gene

Blocks:

Proteasome B-type subunit

InterPro:

ProtoNet:

P28065

Suggested Antigen Peptide Sequences for PSMB9 Gene

GenScript: Design optimal peptide antigens:

Proteasome subunit beta type (A2ACR1_HUMAN)
Proteasome subunit beta type (B0V0T3_HUMAN)
cDNA FLJ54210, moderately similar to Proteasome subunit beta type 9 (EC 3.4.25.1) (B4DZW2_HUMAN)
Really interesting new gene 12 protein (PSB9_HUMAN)
Proteasome subunit beta type (Q5JNW4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P28065

UniProtKB/Swiss-Prot:

PSB9_HUMAN :

Belongs to the peptidase T1B family.

Family:

Belongs to the peptidase T1B family.

Function for PSMB9 Gene

Molecular function for PSMB9 Gene

UniProtKB/Swiss-Prot Function:

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues.

PSB9_HUMAN,P28065

UniProtKB/Swiss-Prot CatalyticActivity:

Reaction=Cleavage of peptide bonds with very broad specificity.; EC=3.4.25.1;.

PSB9_HUMAN,P28065

UniProtKB/Swiss-Prot Induction:

Up-regulated by interferon gamma (at protein level). Up-regulated by IRF1. Up-regulated by tumor necrosis factor-alpha (at protein level). Up-regulated by tetrodotoxin (TTX) in glial cells. Up-regulated in Crohn's bowel disease (CD). Up-regulated by heat shock treatment. Up-regulated by CD40L via the NFKB1 pathway in cancer cells.

PSB9_HUMAN,P28065

GENATLAS Biochemistry:

multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component 2,beta-type subunit 2,stimulated by interferon gamma,involved in the degradation of cytoplasmic antigens for MHC class I antigen presentation pathways

PSMB9

Enzyme Numbers (IUBMB) for PSMB9 Gene

EC 3.4.25.1 ⁵² ⁴

Phenotypes From GWAS Catalog for PSMB9 Gene

Gene Ontology (GO) - Molecular Function for PSMB9 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004175	endopeptidase activity	IBA	21873635
GO:0004298	threonine-type endopeptidase activity	IEA	--
GO:0005515	protein binding	IPI	14733938
GO:0008233	peptidase activity	IEA	--
GO:0016787	hydrolase activity	IEA	--

Phenotypes for PSMB9 Gene

MGI mutant phenotypes for PSMB9:

inferred from 2 alleles

GenomeRNAi human phenotypes for PSMB9:

Human Phenotype Ontology for PSMB9 Gene

HPO Id	HPO Name	Alternative Ids	Definition	Synonyms

Animal Models for PSMB9 Gene

MGI Knock Outs for PSMB9:

Psmb9 ^{Psmb9<tm1Stl>}
Psmb9/Psmb8 ^{Psmb9/Psmb8<tm1Klr>}

Animal Model Products

Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study

CRISPR Products

Applied Biological Materials (abm): CRISPR Clones for PSMB9 - Select products 50% OFF >
* PSMB9 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
* Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All

OriGene CRISPR knockouts for PSMB9
- GA103867
- GA202475
- KN409001
- KN514107

Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PSMB9

genomics-online: gRNA clones - Search results for available PSMB9 gene related products

Santa Cruz Biotechnology (SCBT) CRISPR for PSMB9

miRNA for PSMB9 Gene

miRTarBase miRNAs that target PSMB9

miRNA Products

Search GeneCopoeia for miRNA 3'UTR Target clone products for PSMB9

Browse OriGene miRNA Products For PSMB9

Inhibitory RNA Products

Origene shrna, sirna, and RNAi products in human, mouse, rat for PSMB9
Browse OriGene Inhibitory RNA Products For PSMB9

Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMB9

genomics-online: shRNA clones - Search results for available PSMB9 gene related products

Search Santa Cruz Biotechnology (SCBT) for PSMB9 siRNA/shRNA

Clone Products

Applied Biological Materials (abm): Clones for PSMB9 - Select products 50% OFF >
* PSMB9 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
* Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All

OriGene clones in human,mouse,rat for PSMB9
- SC204194
- MC208896
- RN210701
- SC111676
- SC306334
OriGene ORF clones in human,mouse,rat for PSMB9
- MG223033
- MR223033
- MR223033L3
- MR223033L4
- RC209001
- RC209001L3
- RC209001L4
- RC220308
- RC220308L3
- RC220308L4
- RG209001
- RG220308
- RR210701
- RR210701L3
- RR210701L4
- MR223033L3V
- MR223033L4V
- RC209001L3V
- RC209001L4V
- RC220308L3V
- RC220308L4V
- RR210701L3V
- RR210701L4V
Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling

Sino Biological Human cDNA Clone for PSMB9

Search Addgene for plasmids for PSMB9

Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PSMB9

genomics-online: cdna clones - Search results for available PSMB9 gene related products
orf clones - Search results for available PSMB9 gene related products

Cell Line Products

Browse ESI BIO Cell Lines and PureStem Progenitors for PSMB9

Browse GeneCopoeia Cell Lines

VectorBuilder Stable cell line generation for PSMB9

Horizon Cell Lines for PSMB9

No data available for Transcription Factor Targets and HOMER Transcription for PSMB9 Gene

Localization for PSMB9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMB9 Gene

Cytoplasm. Nucleus.

P28065-PSB9_HUMAN

Subcellular locations from

COMPARTMENTS

Compartment	Confidence
nucleus	5
cytosol	5
plasma membrane	2
extracellular	2
cytoskeleton	2
mitochondrion	2
endoplasmic reticulum	2
lysosome	2
peroxisome	1
endosome	1
golgi apparatus	1

Subcellular locations from the

Human Protein Atlas (HPA)

Cytosol (3)

See all subcellular structures

Gene Ontology (GO) - Cellular Components for PSMB9 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000502	proteasome complex	TAS	8666937
GO:0005634	nucleus	IBA	21873635
GO:0005654	nucleoplasm	TAS	--
GO:0005737	cytoplasm	IBA	21873635
GO:0005829	cytosol	TAS	--

Pathways & Interactions for PSMB9 Gene

SuperPathways for PSMB9 Gene

	SuperPathway	Contained pathways
1	CDK-mediated phosphorylation and removal of Cdc6	Activation of APC/C and APC/C-Cdc20 mediated degradation of mitotic proteins .95 Cdc20-Phospho-APC/C mediated degradation of Cyclin A .95 Autodegradation of the E3 ubiquitin ligase COP1 .95 Stabilization of p53 .95 Regulation of activated PAK-2p34 by proteasome mediated degradation .94 Regulation of Apoptosis .94 CDK-mediated phosphorylation and removal of Cdc6 .94 Ubiquitin-dependent degradation of Cyclin D .94 Ubiquitin-dependent degradation of Cyclin D1 .94 Orc1 removal from chromatin .94 Regulation of DNA replication .94 Switching of origins to a post-replicative state .94 Cyclin A-Cdk2-associated events at S phase entry .93 Cyclin E associated events during G1/S transition .93 APC/C-Cdc20 mediated degradation of Securin .93 APC/C-Cdh1 mediated degradation of Cdc20 and other APC/C-Cdh1 targeted proteins in late mitosis/early G1 .93 APC/C-mediated degradation of cell cycle proteins .93 Regulation of APC/C activators between G1/S and early anaphase .93 Regulation of mitotic cell cycle .93 DNA Replication .93 Synthesis of DNA .93 Vpu mediated degradation of CD4 .93 Autodegradation of Cdh1 by Cdh1-APC/C .91 SCF-beta-TrCP mediated degradation of Emi1 .91 p53-Independent DNA Damage Response .91 p53-Independent G1/S DNA damage checkpoint .91 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A .91 ABC transporter disorders .91 Disorders of transmembrane transporters .91 Defective CFTR causes cystic fibrosis .90 Assembly of the pre-replicative complex .90 Hedgehog ligand biogenesis .90 Hh mutants abrogate ligand secretion .90 APC/C-Cdc20 mediated degradation of mitotic proteins .89 APC-Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint .89 Vif-mediated degradation of APOBEC3G .89 Degradation of GLI1 by the proteasome .89 Degradation of GLI2 by the proteasome .89 GLI3 is processed to GLI3R by the proteasome .89	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis .88 Degradation of AXIN .88 Cellular response to hypoxia .87 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha .87 Regulation of Hypoxia-inducible Factor (HIF) by oxygen .87 CDT1 association with the CDC6-ORC-origin complex .87 Hh mutants that dont undergo autocatalytic processing are degraded by ERAD .87 AUF1 (hnRNP D0) binds and destabilizes mRNA .86 p53-Dependent G1 DNA Damage Response .86 p53-Dependent G1/S DNA damage checkpoint .86 SCF(Skp2)-mediated degradation of p27/p21 .86 Removal of licensing factors from origins .86 NIK-->noncanonical NF-kB signaling .85 Dectin-1 mediated noncanonical NF-kB signaling .84 G1/S DNA Damage Checkpoints .84 Degradation of DVL .83 Cross-presentation of soluble exogenous antigens (endosomes) .82 The role of GTSE1 in G2/M progression after G2 checkpoint .81 Regulation of ornithine decarboxylase (ODC) .81 DNA Replication Pre-Initiation .80 M/G1 Transition .80 Proteasome .78 S Phase .78 Activation of NF-kappaB in B cells .77 Asymmetric localization of PCP proteins .74 FCERI mediated NF-kB activation .72 Regulation of RAS by GAPs .70 PCP/CE pathway .70 Beta-catenin independent WNT signaling .64 Degradation of beta-catenin by the destruction complex .64 Regulation of mRNA stability by proteins that bind AU-rich elements .63 Metabolism of polyamines .60 ABC-family proteins mediated transport .58 TNFR2 non-canonical NF-kB pathway .58 MAPK6/MAPK4 signaling .57 Proteasome Degradation .56 UCH proteinases .47 Apoptosis .31 Programmed Cell Death .31
2	RET signaling	Frs2-mediated activation .95 GRB2 events in EGFR signaling .95 MAPK1/MAPK3 signaling .95 Prolonged ERK activation events .95 RAF/MAP kinase cascade .95 SHC1 events in EGFR signaling .95 Signaling by Leptin .95 SOS-mediated signalling .95 VEGFR2 mediated cell proliferation .95 ARMS-mediated activation .95 Signalling to ERKs .95 Signalling to p38 via RIT and RIN .95 Signalling to RAS .95 Interleukin receptor SHC signaling .95 Interleukin-3, 5 and GM-CSF signaling .94 Interleukin-2 signaling .94 Downstream signal transduction .94 Signaling by PDGF .94 DAP12 signaling .92	RET signaling .92 Insulin receptor signalling cascade .92 Signaling by Insulin receptor .92 IRS-mediated signalling .91 Signaling by EGFR .90 FCERI mediated MAPK activation .90 IGF1R signaling cascade .90 IRS-related events triggered by IGF1R .90 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) .90 DAP12 interactions .89 NCAM signaling for neurite out-growth .89 NGF signalling via TRKA from the plasma membrane .87 MAPK family signaling cascades .87 Signaling by SCF-KIT .85 Signalling by NGF .81 Fc epsilon receptor (FCERI) signaling .79 VEGFA-VEGFR2 Pathway .78 Signaling by VEGF .76 Gastrin-CREB signalling pathway via PKC and MAPK .55
3	Chks in Checkpoint Regulation	Chks in Checkpoint Regulation .59 G2-M Phase Transition .59 Estrogen-mediated S-Phase Entry .55	SREBP Proteolysis .43 DNA Repair Mechanisms .32
4	HIV Life Cycle	HIV Infection .64 Infectious disease .61 Host Interactions of HIV factors .57	Disease .45 Diseases of signal transduction .43
5	Class I MHC mediated antigen processing and presentation	Antigen processing- Ubiquitination and Proteasome degradation .83 Class I MHC mediated antigen processing and presentation .83	Adaptive Immune System .45

Pathways by source for PSMB9 Gene

2 BioSystems pathways for PSMB9 Gene

164 Reactome pathways for PSMB9 Gene

1 KEGG pathway for PSMB9 Gene

Proteasome

1 GeneGo (Thomson Reuters) pathway for PSMB9 Gene

Immune response Antigen presentation by MHC class I

12 Qiagen pathways for PSMB9 Gene

CDK5 Pathway
Chks in Checkpoint Regulation
DNA Repair Mechanisms
Estrogen-mediated S-Phase Entry
G2-M Phase Transition

Interacting Proteins for PSMB9 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)

Selected Interacting proteins: P28065-PSB9_HUMAN ENSP00000363993 for PSMB9 Gene via UniProtKB MINT STRING IID

Symbol	External ID(s)	Details
GRIP1	Q9Y3R0 ⁴ ²⁰ ¹²⁷	EBI-603300, EBI-5349621 MINT-3291398 IID: # exp=1
NCOA1	Q15788 ⁴ ²⁰ ¹²⁷	EBI-603300, EBI-455189 MINT-3291505 IID: # exp=1 # pred=1
NCOA3	Q9Y6Q9 ⁴ ²⁰ ¹²⁷	EBI-603300, EBI-81196 MINT-3291741 IID: # exp=1 # pred=1
POMP	Q9Y244 ⁴ ¹²⁷ ENSP00000370222 ²¹	EBI-603300, EBI-696895 STRING: ENSP00000370222 IID: # exp=5 # pred=1
PSMB7	Q99436 ⁴ ¹²⁷ ENSP00000259457 ²¹	EBI-603300, EBI-603319 STRING: ENSP00000259457 IID: # exp=6 # pred=3

GPS-Prot Interaction Network for PSMB9

;

Gene Ontology (GO) - Biological Process for PSMB9 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000165	MAPK cascade	TAS	--
GO:0000209	protein polyubiquitination	TAS	--
GO:0002223	stimulatory C-type lectin receptor signaling pathway	TAS	--
GO:0002376	immune system process	IEA	--
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	TAS	--

No data available for SIGNOR curated interactions for PSMB9 Gene

Drugs & Compounds for PSMB9 Gene

(6) Drugs for PSMB9 Gene - From: DrugBank, ApexBio, and DGIdb

Name	Status	Disease Links	Group	Role	Mechanism of Action	Clinical Trials
carfilzomib	Approved, Investigational	MalaCards Medline Plus	Pharma	Target, inhibitor, other	Other, 20S Proteasome Inhibitor	0
Bortezomib	Approved, Investigational	MalaCards Medline Plus	Pharma	inhibitor, other	Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors	888
Celastrol		MalaCards Medline Plus	Pharma		Antioxidant, anti-inflammatory and immunosuppressive agent	0
Dihydroeponemycin		MalaCards Medline Plus	Pharma		Proteasome inhibitor,antitumor reagent,eponemycin ddrivative	0
MLN2238		MalaCards Medline Plus	Pharma		β5 site of the 20S proteasome inhibitor	0

(4) ApexBio Compounds for PSMB9 Gene

Compound	Action	Cas Number
Celastrol	Antioxidant, anti-inflammatory and immunosuppressive agent	34157-83-0
Dihydroeponemycin	Proteasome inhibitor,antitumor reagent,eponemycin ddrivative	126463-64-7
MLN2238	β5 site of the 20S proteasome inhibitor	1072833-77-2
ONX-0914 (PR-957)	Immunoproteasome inhibitor,potent and selective	960374-59-8

Drug Products

Creative Biomart Recombinant Human PSMB9, His-tagged

Browse Tocris compounds for PSMB9

ApexBio compounds for PSMB9

Transcripts for PSMB9 Gene