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PSMB8 Gene(Protein Coding)

Proteasome Subunit Beta 8

GCID:
GC06M032840
GIFtS:
57
Genes Participants
UDN Logo

Aliases for PSMB8 Gene

Aliases for PSMB8 Gene

  • Proteasome Subunit Beta 8 2 3 5
  • Multicatalytic Endopeptidase Complex Subunit C13 3 4
  • Really Interesting New Gene 10 Protein 3 4
  • Low Molecular Mass Protein 7 3 4
  • Proteasome Component C13 3 4
  • Macropain Subunit C13 3 4
  • PSMB5i 3 4
  • RING10 3 4
  • LMP7 3 4
  • Proteasome (Prosome, Macropain) Subunit, Beta Type, 8 (Large Multifunctional Peptidase 7) 3
  • Proteasome (Prosome, Macropain) Subunit, Beta Type, 8 (Large Multifunctional Protease 7) 2
  • Proteasome (Prosome, Macropain) Subunit, Beta Type, 8 2
  • Large Multifunctional Peptidase 7 2
  • Proteasome Catalytic Subunit 3i 3
  • Low Molecular Weight Protein 7 3
  • Proteasome Subunit Beta Type-8 3
  • Proteasome Subunit Beta 5i 3
  • Proteasome Subunit Beta-5i 4
  • Proteasome-Related Gene 7 3
  • Protease Component C13 3
  • Proteasome Subunit Y2 3
  • EC 3.4.25.1 4
  • D6S216E 3
  • D6S216 3
  • ALDD 3
  • NKJO 3
  • JMP 3
  • Y2 4

External Ids for PSMB8 Gene

Previous HGNC Symbols for PSMB8 Gene

  • LMP7

Previous GeneCards Identifiers for PSMB8 Gene

  • GC06M032805
  • GC06M032579
  • GC06M032855
  • GC06M032916
  • GC06M032808

Summaries for PSMB8 Gene

Entrez Gene Summary for PSMB8 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit. [provided by RefSeq, Jul 2008]

CIViC summary for PSMB8 Gene

GeneCards Summary for PSMB8 Gene

PSMB8 (Proteasome Subunit Beta 8) is a Protein Coding gene. Diseases associated with PSMB8 include Autoinflammation, Lipodystrophy, And Dermatosis Syndrome and Nakajo Syndrome. Among its related pathways are Cell Cycle, Mitotic and RET signaling. Gene Ontology (GO) annotations related to this gene include threonine-type endopeptidase activity. An important paralog of this gene is PSMB5.

UniProtKB/Swiss-Prot for PSMB8 Gene

  • The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes.

Gene Wiki entry for PSMB8 Gene

Additional gene information for PSMB8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMB8 Gene

Genomics for PSMB8 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for PSMB8 Gene

Promoters and enhancers for PSMB8 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH06J032837 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 656.8 +2.7 2696 9.8 HDGF PKNOX1 SMAD1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 PSMB9 PSMB8-AS1 PSMB8 TAP2 HLA-DMA BRD2 VPS52 TAP1 DAXX LEMD2
GH06J032940 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 15.4 -99.3 -99262 8.8 HDGF ATF1 ARID4B ZNF2 IRF4 BRCA1 YY1 ZNF207 ZNF143 ATF7 HLA-DMA BRD2 PSMB9 TAP1 TAP2 PSMB8 RING1 HLA-DMB HLA-DOB ENSG00000223837
GH06J032965 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 11.1 -125.7 -125734 10.4 ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 ZNF263 BRD2 HLA-DMA ENSG00000223837 LEMD2 ATF6B VPS52 RXRB DAXX WDR46 HCG25
GH06J032851 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.1 -9.0 -8971 5.2 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 PSMB9 TAP1 BRD2 VPS52 LEMD2 PSMB8 RXRB ATF6B HLA-DOB C4A
GH06J032435 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.1 +405.5 405497 7.5 HDGF PKNOX1 ATF1 SMAD1 RB1 STAT5A BMI1 BATF KLF5 IRF4 HLA-DRA HLA-DRB1 HLA-DQB1 HLA-DRB5 HLA-DQA2 HLA-DRB6 C4A HLA-DQA1 HLA-DQB1-AS1 PSMB8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSMB8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PSMB8 gene promoter:
  • STAT3

Genomic Locations for PSMB8 Gene

Genomic Locations for PSMB8 Gene
chr6:32,840,717-32,844,935
(GRCh38/hg38)
Size:
4,219 bases
Orientation:
Minus strand
chr6:32,808,494-32,812,712
(GRCh37/hg19)
Size:
4,219 bases
Orientation:
Minus strand

Genomic View for PSMB8 Gene

Genes around PSMB8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMB8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMB8 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PSMB8 Gene

Proteins for PSMB8 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for PSMB8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28062-PSB8_HUMAN
    Recommended name:
    Proteasome subunit beta type-8
    Protein Accession:
    P28062
    Secondary Accessions:
    • B0UZC0
    • Q29824
    • Q5JNW6
    • Q5QNR8
    • Q96J48

    Protein attributes for PSMB8 Gene

    Size:
    276 amino acids
    Molecular mass:
    30354 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Component of the immunoproteasome, where it displaces the equivalent housekeeping subunit PSMB5. Component of the spermatoproteasome, a form of the proteasome specifically found in testis. Directly interacts with POMP. Interacts with HIV-1 TAT protein. Interacts with TAP1.

    Three dimensional structures from OCA and Proteopedia for PSMB8 Gene

    Alternative splice isoforms for PSMB8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMB8 Gene

Protein Expression for PSMB8 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for PSMB8 Gene

  • Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile proteolytic activity.
  • Ubiquitination at posLast=252252, Lys179, and Lys153
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMB8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PSMB8 Gene

Domains & Families for PSMB8 Gene

Gene Families for PSMB8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PSMB8 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PSMB8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P28062

UniProtKB/Swiss-Prot:

PSB8_HUMAN :
  • Belongs to the peptidase T1B family.
Family:
  • Belongs to the peptidase T1B family.
genes like me logo Genes that share domains with PSMB8: view

Function for PSMB8 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for PSMB8 Gene

UniProtKB/Swiss-Prot Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes.
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of peptide bonds with very broad specificity.
UniProtKB/Swiss-Prot Induction:
Up-regulated by IFNG/IFN-gamma and IRF1 (at protein level). Up-regulated by TNF (at protein level). Up-regulated by tetrodotoxin (TTX) in glial cells. Up-regulated in Crohns bowel disease (CD). Down-regulated by the selective inhibitor PR-957. Down-regulated in mature dendritic cells by HSV-1 infection. Up-regulated by heat shock treatment.
GENATLAS Biochemistry:
multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component 7,beta-type subunit,stimulated by interferon gamma,involved in the degradation of cytoplasmic antigens for MHC class I antigen presentation pathways

Enzyme Numbers (IUBMB) for PSMB8 Gene

Phenotypes From GWAS Catalog for PSMB8 Gene

Gene Ontology (GO) - Molecular Function for PSMB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IBA,IEA --
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 15303969
GO:0008233 peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PSMB8: view
genes like me logo Genes that share phenotypes with PSMB8: view

Human Phenotype Ontology for PSMB8 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PSMB8 Gene

MGI Knock Outs for PSMB8:

Animal Model Products

CRISPR Products

miRNA for PSMB8 Gene

miRTarBase miRNAs that target PSMB8

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMB8

No data available for Transcription Factor Targets and HOMER Transcription for PSMB8 Gene

Localization for PSMB8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMB8 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMB8 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
endoplasmic reticulum 2
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PSMB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex TAS,IDA 26524591
GO:0005634 nucleus IEA,IBA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PSMB8: view

Pathways & Interactions for PSMB8 Gene

SuperPathways for PSMB8 Gene

PathCards logo More details on SuperPathways for PSMB8
SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
Activation of APC/C and APC/C-Cdc20 mediated degradation of mitotic proteins
.95
Cdc20-Phospho-APC/C mediated degradation of Cyclin A
.95
Autodegradation of the E3 ubiquitin ligase COP1
.95
Stabilization of p53
.95
Regulation of activated PAK-2p34 by proteasome mediated degradation
.94
Regulation of Apoptosis
.94
CDK-mediated phosphorylation and removal of Cdc6
.94
Ubiquitin-dependent degradation of Cyclin D
.94
Ubiquitin-dependent degradation of Cyclin D1
.94
Orc1 removal from chromatin
.94
Regulation of DNA replication
.94
Switching of origins to a post-replicative state
.94
Cyclin A-Cdk2-associated events at S phase entry
.93
Cyclin E associated events during G1/S transition
.93
APC/C-Cdc20 mediated degradation of Securin
.93
APC/C-Cdh1 mediated degradation of Cdc20 and other APC/C-Cdh1 targeted proteins in late mitosis/early G1
.93
APC/C-mediated degradation of cell cycle proteins
.93
Regulation of APC/C activators between G1/S and early anaphase
.93
Regulation of mitotic cell cycle
.93
DNA Replication
.93
Synthesis of DNA
.93
Vpu mediated degradation of CD4
.93
Autodegradation of Cdh1 by Cdh1-APC/C
.91
SCF-beta-TrCP mediated degradation of Emi1
.91
p53-Independent DNA Damage Response
.91
p53-Independent G1/S DNA damage checkpoint
.91
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
.91
ABC transporter disorders
.91
Disorders of transmembrane transporters
.91
Defective CFTR causes cystic fibrosis
.90
Assembly of the pre-replicative complex
.90
Hedgehog ligand biogenesis
.90
Hh mutants abrogate ligand secretion
.90
APC/C-Cdc20 mediated degradation of mitotic proteins
.89
APC-Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
.89
Vif-mediated degradation of APOBEC3G
.89
Degradation of GLI1 by the proteasome
.89
Degradation of GLI2 by the proteasome
.89
GLI3 is processed to GLI3R by the proteasome
.89
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
.88
Degradation of AXIN
.88
Cellular response to hypoxia
.87
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
.87
Regulation of Hypoxia-inducible Factor (HIF) by oxygen
.87
CDT1 association with the CDC6-ORC-origin complex
.87
Hh mutants that dont undergo autocatalytic processing are degraded by ERAD
.87
AUF1 (hnRNP D0) binds and destabilizes mRNA
.86
p53-Dependent G1 DNA Damage Response
.86
p53-Dependent G1/S DNA damage checkpoint
.86
SCF(Skp2)-mediated degradation of p27/p21
.86
Removal of licensing factors from origins
.86
NIK-->noncanonical NF-kB signaling
.85
Dectin-1 mediated noncanonical NF-kB signaling
.84
G1/S DNA Damage Checkpoints
.84
Degradation of DVL
.83
Cross-presentation of soluble exogenous antigens (endosomes)
.82
The role of GTSE1 in G2/M progression after G2 checkpoint
.81
Regulation of ornithine decarboxylase (ODC)
.81
DNA Replication Pre-Initiation
.80
M/G1 Transition
.80
Proteasome
.78
S Phase
.78
Activation of NF-kappaB in B cells
.77
Asymmetric localization of PCP proteins
.74
FCERI mediated NF-kB activation
.72
Regulation of RAS by GAPs
.70
PCP/CE pathway
.70
Beta-catenin independent WNT signaling
.64
Degradation of beta-catenin by the destruction complex
.64
Regulation of mRNA stability by proteins that bind AU-rich elements
.63
Metabolism of polyamines
.60
TNFR2 non-canonical NF-kB pathway
.58
ABC-family proteins mediated transport
.57
MAPK6/MAPK4 signaling
.57
Proteasome Degradation
.56
UCH proteinases
.47
Canonical Wnt Pathway
.32
Apoptosis
.31
Programmed Cell Death
.31
2 RET signaling
Frs2-mediated activation
.95
GRB2 events in EGFR signaling
.95
MAPK1/MAPK3 signaling
.95
Prolonged ERK activation events
.95
RAF/MAP kinase cascade
.95
SHC1 events in EGFR signaling
.95
Signaling by Leptin
.95
SOS-mediated signalling
.95
VEGFR2 mediated cell proliferation
.95
ARMS-mediated activation
.95
Signalling to ERKs
.95
Signalling to p38 via RIT and RIN
.95
Signalling to RAS
.95
Interleukin receptor SHC signaling
.95
Interleukin-3, 5 and GM-CSF signaling
.94
Interleukin-2 signaling
.94
Downstream signal transduction
.94
Signaling by PDGF
.94
DAP12 signaling
.92
RET signaling
.92
Insulin receptor signalling cascade
.92
Signaling by Insulin receptor
.92
IRS-mediated signalling
.91
Signaling by EGFR
.90
FCERI mediated MAPK activation
.90
IGF1R signaling cascade
.90
IRS-related events triggered by IGF1R
.90
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
.90
DAP12 interactions
.89
NCAM signaling for neurite out-growth
.89
NGF signalling via TRKA from the plasma membrane
.87
MAPK family signaling cascades
.87
Signaling by SCF-KIT
.85
Signalling by NGF
.81
Fc epsilon receptor (FCERI) signaling
.79
VEGFA-VEGFR2 Pathway
.78
Signaling by VEGF
.76
Gastrin-CREB signalling pathway via PKC and MAPK
.55
3 Chks in Checkpoint Regulation
Chks in Checkpoint Regulation
.59
G2-M Phase Transition
.59
Estrogen-mediated S-Phase Entry
.55
SREBP Proteolysis
.43
DNA Repair Mechanisms
.32
4 HIV Life Cycle
HIV Infection
.64
Infectious disease
.61
Host Interactions of HIV factors
.57
Disease
.45
Diseases of signal transduction
.43
5 Class I MHC mediated antigen processing and presentation
Antigen processing- Ubiquitination and Proteasome degradation
.83
Class I MHC mediated antigen processing and presentation
.83
Adaptive Immune System
.45
genes like me logo Genes that share pathways with PSMB8: view

Pathways by source for PSMB8 Gene

1 Sino Biological pathway for PSMB8 Gene
1 BioSystems pathway for PSMB8 Gene
1 KEGG pathway for PSMB8 Gene
1 GeneGo (Thomson Reuters) pathway for PSMB8 Gene
1 Cell Signaling Technology pathway for PSMB8 Gene

Gene Ontology (GO) - Biological Process for PSMB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002376 immune system process IEA --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
genes like me logo Genes that share ontologies with PSMB8: view

No data available for SIGNOR curated interactions for PSMB8 Gene

Drugs & Compounds for PSMB8 Gene

Products:

  1. Drug

(18) Drugs for PSMB8 Gene - From: DrugBank, DGIdb, FDA Approved Drugs, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
carfilzomib Approved, Investigational Pharma other, Inhibitor, Target Other, 20S Proteasome Inhibitor 0
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 826
Kyprolis Approved July 2012 Pharma 0
AM 114 Pharma 20S proteasome inhibitor 0
Bortezomib (PS-341) Pharma Proteasome Inhibitor 0
genes like me logo Genes that share compounds with PSMB8: view

Transcripts for PSMB8 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for PSMB8 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(479) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PSMB8 Gene

Proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMB8

Alternative Splicing Database (ASD) splice patterns (SP) for PSMB8 Gene

No ASD Table

Relevant External Links for PSMB8 Gene

GeneLoc Exon Structure for
PSMB8
ECgene alternative splicing isoforms for
PSMB8

Expression for PSMB8 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSMB8 Gene

mRNA expression in normal human tissues for PSMB8 Gene
mRNA expression by BioGPS for PSMB8 GenemRNA expression by GTEx for PSMB8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PSMB8 Gene

This gene is overexpressed in Whole Blood (x6.8).

Protein differential expression in normal tissues from HIPED for PSMB8 Gene

This gene is overexpressed in Liver, secretome (13.0), Tlymphocyte (7.3), and Lymph node (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMB8 Gene



Protein tissue co-expression partners for PSMB8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PSMB8 Gene:

PSMB8

SOURCE GeneReport for Unigene cluster for PSMB8 Gene:

Hs.180062

Evidence on tissue expression from TISSUES for PSMB8 Gene

  • Blood(4.7)
  • Liver(4.4)
  • Skin(4.4)
  • Lung(3.4)
  • Intestine(3.3)
  • Nervous system(2.9)
  • Spleen(2.6)
  • Kidney(2.4)

Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMB8 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • ear
  • eye
  • face
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • outer ear
  • skull
  • tongue
Thorax:
  • chest wall
  • clavicle
  • heart
  • heart valve
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • duodenum
  • intestine
  • liver
  • pancreas
  • small intestine
  • spleen
Pelvis:
  • pelvis
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • lymph node
  • red blood cell
  • skin
  • spinal column
  • sweat gland
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with PSMB8: view

No data available for mRNA Expression by UniProt/SwissProt for PSMB8 Gene

Orthologs for PSMB8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PSMB8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia PSMB8 34 33
  • 98.91 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia PSMB8 34 33
  • 87.2 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia PSMB8 34 33
  • 87.08 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Psmb8 33
  • 84.12 (n)
mouse
(Mus musculus)
 Mammalia Psmb8 16 34 33
  • 84.06 (n)
oppossum
(Monodelphis domestica)
 Mammalia PSMB8 34
  • 74 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia PSMB8 34
  • 62 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia PSMB8 34
  • 71 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia psmb8 33
  • 67.42 (n)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.162 33
zebrafish
(Danio rerio)
 Actinopterygii psmb8 34 33 33
  • 64.93 (n)
 OneToOne
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.8289 33
fruit fly
(Drosophila melanogaster)
 Insecta Pros&bgr;5 35
  • 52 (a)
CG9868 35
  • 51 (a)
Prosbeta5 34
  • 49 (a)
 ManyToMany
CG31742 34
  • 40 (a)
 ManyToMany
Prosbeta5R 34
  • 37 (a)
 ManyToMany
worm
(Caenorhabditis elegans)
 Secernentea pbs-5 34