The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiq... See more...

Aliases for PSMB7 Gene

Aliases for PSMB7 Gene

  • Proteasome 20S Subunit Beta 7 2 3
  • Proteasome Subunit Beta 7 2 3 5
  • Proteasome (Prosome, Macropain) Subunit, Beta Type, 7 2 3
  • Multicatalytic Endopeptidase Complex Chain Z 3 4
  • Proteasome Subunit Beta Type-7 3 4
  • Proteasome Subunit Z 3 4
  • Macropain Chain Z 3 4
  • EC 3.4.25.1 4 52
  • Z 3 4
  • Epididymis Secretory Sperm Binding Protein 3
  • Proteasome Catalytic Subunit 2 3
  • Protein Serine Kinase C17 3
  • Proteasome Subunit Alpha 3
  • Proteasome Subunit Beta2 3
  • Proteasome Subunit Β2 2

External Ids for PSMB7 Gene

Previous GeneCards Identifiers for PSMB7 Gene

  • GC09M118230
  • GC09M118762
  • GC09M120569
  • GC09M122491
  • GC09M124195
  • GC09M126155
  • GC09M127115
  • GC09M096700

Summaries for PSMB7 Gene

Entrez Gene Summary for PSMB7 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Expression of this catalytic subunit is downregulated by gamma interferon, and proteolytic processing is required to generate a mature subunit. A pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Jul 2012]

GeneCards Summary for PSMB7 Gene

PSMB7 (Proteasome 20S Subunit Beta 7) is a Protein Coding gene. Diseases associated with PSMB7 include Colorectal Cancer. Among its related pathways are Regulation of degradation of deltaF508 CFTR in CF and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include threonine-type endopeptidase activity. An important paralog of this gene is PSMB10.

UniProtKB/Swiss-Prot Summary for PSMB7 Gene

  • Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity.

Gene Wiki entry for PSMB7 Gene

Additional gene information for PSMB7 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSMB7 Gene

Genomics for PSMB7 Gene

GeneHancer (GH) Regulatory Elements for PSMB7 Gene

Promoters and enhancers for PSMB7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSMB7 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PSMB7

Top Transcription factor binding sites by QIAGEN in the PSMB7 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • RSRFC4

Genomic Locations for PSMB7 Gene

Genomic Locations for PSMB7 Gene
chr9:124,353,465-124,415,473
(GRCh38/hg38)
Size:
62,009 bases
Orientation:
Minus strand
chr9:127,115,744-127,177,723
(GRCh37/hg19)
Size:
61,980 bases
Orientation:
Minus strand

Genomic View for PSMB7 Gene

Genes around PSMB7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMB7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMB7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMB7 Gene

Proteins for PSMB7 Gene

  • Protein details for PSMB7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99436-PSB7_HUMAN
    Recommended name:
    Proteasome subunit beta type-7
    Protein Accession:
    Q99436
    Secondary Accessions:
    • B4E0P1
    • Q5TBG6
    • Q96AG8
    • Q9BWA7

    Protein attributes for PSMB7 Gene

    Size:
    277 amino acids
    Molecular mass:
    29965 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.
    • (Microbial infection) Interacts with HIV-1 Tat protein.

    Three dimensional structures from OCA and Proteopedia for PSMB7 Gene

    Alternative splice isoforms for PSMB7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMB7 Gene

Selected DME Specific Peptides for PSMB7 Gene

Q99436:
  • IYPHGSTD
  • GSGSLAA
  • NDLGSGSN
  • VPNKKGTR
  • LGADTRAT
  • GAGTAADT
  • IYCCGAG
  • PVGGFSFDNCRRNA

Post-translational modifications for PSMB7 Gene

  • Ubiquitination at Lys31, Lys127, Lys225, and Lys249
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMB7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PSMB7 Gene

Gene Families for PSMB7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PSMB7 Gene

Suggested Antigen Peptide Sequences for PSMB7 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ60039, highly similar to Proteasome subunit beta type 7 (EC 3.4.25.1) (B4E0P1_HUMAN)
  • Proteasome subunit Z (PSB7_HUMAN)
  • Proteasome subunit beta type (Q6IBT1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q99436

UniProtKB/Swiss-Prot:

PSB7_HUMAN :
  • Belongs to the peptidase T1B family.
Family:
  • Belongs to the peptidase T1B family.
genes like me logo Genes that share domains with PSMB7: view

Function for PSMB7 Gene

Molecular function for PSMB7 Gene

UniProtKB/Swiss-Prot Function:
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Cleavage of peptide bonds with very broad specificity.; EC=3.4.25.1; Evidence=. ;.
GENATLAS Biochemistry:
multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,beta type subunit Z,30kDa,homologous of mouse Psmb7,removed from the complex by MECL1/PSMD7 after IFNG stimulation

Enzyme Numbers (IUBMB) for PSMB7 Gene

Phenotypes From GWAS Catalog for PSMB7 Gene

Gene Ontology (GO) - Molecular Function for PSMB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IEA,IBA 21873635
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 14733938
GO:0008233 peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PSMB7: view
genes like me logo Genes that share phenotypes with PSMB7: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMB7 Gene

Localization for PSMB7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMB7 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMB7 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 4
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PSMB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IEA,IDA 17323924
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IEA,IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA,IEA 21873635
genes like me logo Genes that share ontologies with PSMB7: view

Pathways & Interactions for PSMB7 Gene

PathCards logo

SuperPathways for PSMB7 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 Chks in Checkpoint Regulation
.59
.59
.55
.43
.32
.31
4 HIV Life Cycle
.45
5 Class I MHC mediated antigen processing and presentation
genes like me logo Genes that share pathways with PSMB7: view

Pathways by source for PSMB7 Gene

1 KEGG pathway for PSMB7 Gene
4 GeneGo (Thomson Reuters) pathways for PSMB7 Gene
  • Immune response Antigen presentation by MHC class I
  • Regulation of degradation of deltaF508 CFTR in CF
  • Regulation of degradation of wt-CFTR
  • Transcription Ligand-Dependent Transcription of Retinoid-Target genes
17 Qiagen pathways for PSMB7 Gene
  • CDK5 Pathway
  • Chks in Checkpoint Regulation
  • DNA Repair Mechanisms
  • Estrogen-mediated S-Phase Entry
  • G2-M Phase Transition

Gene Ontology (GO) - Biological Process for PSMB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PSMB7: view

No data available for SIGNOR curated interactions for PSMB7 Gene

Drugs & Compounds for PSMB7 Gene

(3) Drugs for PSMB7 Gene - From: DrugBank and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 888
carfilzomib Approved, Investigational Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Experimental Pharma Target 0
genes like me logo Genes that share compounds with PSMB7: view

Transcripts for PSMB7 Gene

mRNA/cDNA for PSMB7 Gene

1 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMB7 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10
SP1: - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - -
SP5: -
SP6: -

Relevant External Links for PSMB7 Gene

GeneLoc Exon Structure for
PSMB7

Expression for PSMB7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PSMB7 Gene

Protein differential expression in normal tissues from HIPED for PSMB7 Gene

This gene is overexpressed in Amniocyte (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMB7 Gene



Protein tissue co-expression partners for PSMB7 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PSMB7

SOURCE GeneReport for Unigene cluster for PSMB7 Gene:

Hs.213470

mRNA Expression by UniProt/SwissProt for PSMB7 Gene:

Q99436-PSB7_HUMAN
Tissue specificity: Expressed at a low level in colonic mucosa. Up-regulated in colorectal cancer tissues.

Evidence on tissue expression from TISSUES for PSMB7 Gene

  • Liver(4.7)
  • Lung(4.7)
  • Nervous system(4.3)
  • Skin(3.1)
  • Intestine(2.6)
  • Muscle(2.4)
  • Pancreas(2.4)
  • Eye(2.2)
  • Kidney(2.2)
  • Adrenal gland(2)
  • Heart(2)
genes like me logo Genes that share expression patterns with PSMB7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMB7 Gene

Orthologs for PSMB7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMB7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMB7 31 30
  • 99.52 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PSMB7 31
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PSMB7 31 30
  • 92.06 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PSMB7 31 30
  • 91.34 (n)
OneToMany
-- 31
  • 79 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Psmb7 30
  • 90.25 (n)
mouse
(Mus musculus)
Mammalia Psmb7 17 31 30
  • 90.01 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PSMB7 31
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves PSMB7 31 30
  • 76.77 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSMB7 31
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psmb7 30
  • 72.68 (n)
Str.421 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.3306 30
zebrafish
(Danio rerio)
Actinopterygii psmb7 31 30 30
  • 71.36 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11154 30
fruit fly
(Drosophila melanogaster)
Insecta Pros&bgr;2 32
  • 64 (a)
Prosbeta2 31 30
  • 62.79 (n)
ManyToMany
CG18341 32
  • 57 (a)
Prosbeta2R1 31
  • 48 (a)
ManyToMany
Prosbeta2R2 31
  • 31 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011423 30
  • 63.98 (n)
worm
(Caenorhabditis elegans)
Secernentea pbs-2 31
  • 41 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A02233g 30
  • 56.6 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PUP1 33 31 30
  • 56.12 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons PBB1 30
  • 58.17 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6659 30
soybean
(Glycine max)
eudicotyledons Gma.5581 30
rice
(Oryza sativa)
Liliopsida Os05g0187000 30
  • 60.55 (n)
Os.12182 30
barley
(Hordeum vulgare)
Liliopsida Hv.2613 30
corn
(Zea mays)
Liliopsida Zm.6982 30
wheat
(Triticum aestivum)
Liliopsida Ta.14021 30
bread mold
(Neurospora crassa)
Ascomycetes NCU08605 30
  • 59.97 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pup1 30
  • 59.26 (n)
sea squirt
(Ciona savignyi)
Ascidiacea Cin.7320 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7320 30
Species where no ortholog for PSMB7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMB7 Gene

ENSEMBL:
Gene Tree for PSMB7 (if available)
TreeFam:
Gene Tree for PSMB7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PSMB7: view image

Paralogs for PSMB7 Gene

(3) SIMAP similar genes for PSMB7 Gene using alignment to 4 proteins:

  • PSB7_HUMAN
  • B4E0P1_HUMAN
  • Q5TBG5_HUMAN
  • Q6IBT1_HUMAN

Pseudogenes.org Pseudogenes for PSMB7 Gene

genes like me logo Genes that share paralogs with PSMB7: view

Variants for PSMB7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PSMB7 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs4574 - p.Val39Ala

Additional dbSNP identifiers (rs#s) for PSMB7 Gene

Structural Variations from Database of Genomic Variants (DGV) for PSMB7 Gene

Variant ID Type Subtype PubMed ID
dgv12866n54 CNV loss 21841781
esv3621721 CNV gain 21293372
esv3621722 CNV gain 21293372
nsv471322 CNV loss 18288195
nsv519767 CNV loss 19592680
nsv615290 CNV loss 21841781

Variation tolerance for PSMB7 Gene

Residual Variation Intolerance Score: 44.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.39; 94.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PSMB7 Gene

Human Gene Mutation Database (HGMD)
PSMB7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMB7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMB7 Gene

Disorders for PSMB7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PSMB7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
colorectal cancer
  • crc
- elite association - COSMIC cancer census association via MalaCards
Search PSMB7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PSMB7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PSMB7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSMB7 Gene

Publications for PSMB7 Gene

  1. An atomic structure of the human 26S proteasome. (PMID: 27428775) Huang X … Shi Y (Nature structural & molecular biology 2016) 3 4 54
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  3. Proteomic expression analysis of surgical human colorectal cancer tissues: up-regulation of PSB7, PRDX1, and SRP9 and hypoxic adaptation in cancer. (PMID: 18549262) Rho JH … Roehrl MH (Journal of proteome research 2008) 3 4 54
  4. Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X … Huang L (Biochemistry 2007) 3 4 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

Products for PSMB7 Gene