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The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiq... See more...
Aliases for PSMB6 Gene
Aliases for PSMB6 Gene
External Ids for PSMB6 Gene
- HGNC: 9543
- NCBI Entrez Gene: 5694
- Ensembl: ENSG00000142507
- OMIM®: 600307
- UniProtKB/Swiss-Prot: P28072
Previous GeneCards Identifiers for PSMB6 Gene
- GC17P005126
- GC17P004650
- GC17P004906
- GC17P004646
- GC17P004699
- GC17P004587
Summaries for PSMB6 Gene
-
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
GeneCards Summary for PSMB6 Gene
PSMB6 (Proteasome 20S Subunit Beta 6) is a Protein Coding gene. Among its related pathways are Downstream signaling events of B Cell Receptor (BCR) and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include endopeptidase activity and threonine-type endopeptidase activity. An important paralog of this gene is PSMB9.
UniProtKB/Swiss-Prot Summary for PSMB6 Gene
-
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB6 displays a peptidylglutamyl-hydrolizing activity also termed postacidic or caspase-like activity, meaning that the peptides bond hydrolysis occurs directly after acidic residues.
Additional gene information for PSMB6 Gene
- HGNC (9543)
- NCBI Entrez Gene (5694)
- Ensembl (ENSG00000142507)
- OMIM® (600307)
- UniProtKB/Swiss-Prot (P28072)
- Open Targets Platform(ENSG00000142507)
- Search for PSMB6 at DataMed
- Search for PSMB6 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSMB6 Gene
Genomics for PSMB6 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PSMB6 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH17J004795 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE CraniofacialAtlas | 250.7 | +0.2 | 157 | 2.2 | TBP ZBTB10 MXD4 SIX5 MNT DEK SMAD5 ETS1 MBD2 ZNF217 | HE856254 HSALNG0114053 PSMB6 ZNF594 PLD2 ZNF594-DT ENSG00000262165 ENSG00000262227 ZZEF1 ZNF232 | |
| GH17J004843 | Enhancer | 0.7 | FANTOM5 ENCODE dbSUPER | 11.9 | +48.7 | 48685 | 2.2 | NFE2 | ARRB2 ZMYND15 CXCL16 C17orf107 PLD2 PSMB6 RPS12P29 VMO1 GLTPD2 LOC101559451 | |
| GH17J004842 | Enhancer | 0.3 | dbSUPER | 11.9 | +46.7 | 46661 | 1.1 | CEBPB | CHRNE PLD2 PSMB6 GLTPD2 VMO1 ENO3 PFN1 CAMTA2 MINK1 lnc-CHRNE-4 | |
| GH17J004791 | Promoter | 0.3 | Ensembl | 0.7 | -4.5 | -4544 | 0.4 | lnc-VMO1-1 GLTPD2 PSMB6 | ||
| GH17J004801 | Enhancer | 0.2 | FANTOM5 | 0.4 | +5.2 | 5248 | 0.4 | piR-57460-270 ENSG00000262165 MINK1 ZNF232 KIF1C lnc-VMO1-2 PSMB6 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PSMB6 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PSMB6
- Top Transcription factor binding sites by QIAGEN in the PSMB6 gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- FOXD1
- Lmo2
- LyF-1
- Olf-1
- STAT1
- STAT1alpha
- STAT1beta
Genomic Locations for PSMB6 Gene
Latest Assembly
- chr17:4,796,144-4,798,502
- (GRCh38/hg38)
- Size:
- 2,359 bases
- Orientation:
- Plus strand
Previous Assembly
- chr17:4,699,459-4,701,790
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 2,332 bases
- Orientation:
- Plus strand
- chr17:4,699,439-4,701,790
- (GRCh37/hg19 by Ensembl)
- Size:
- 2,352 bases
- Orientation:
- Plus strand
Genomic View for PSMB6 Gene
Genes around PSMB6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p13.2 by HGNC
- 17p13.2 by Entrez Gene
- 17p13.2 by Ensembl
PSMB6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PSMB6 Gene
Proteins for PSMB6 Gene
-
Protein details for PSMB6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P28072-PSB6_HUMAN
- Recommended name:
- Proteasome subunit beta type-6
- Protein Accession:
- P28072
- Q96J55
Protein attributes for PSMB6 Gene
- Size:
- 239 amino acids
- Molecular mass:
- 25358 Da
- Quaternary structure:
-
- The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.
- (Microbial infection) Interacts with HIV-1 protein Tat.
Protein Expression for PSMB6 Gene
Selected DME Specific Peptides for PSMB6 Gene
- P28072:
-
- CRSGSAAD
- TGTTIMAV
- YIANRVT
- RDGSSGGV
- ALAMERDGSSGG
- GSGSSYIYGYVDA
- GGSGSSY
Post-translational modifications for PSMB6 Gene
Other Protein References for PSMB6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
-
Custom Antibody ServicesOriGene Antibodies for PSMB6
- Novus Biologicals Antibodies for PSMB6
-
Abcam antibodies for PSMB6
- Invitrogen Antibodies for PSMB6 (AFLGC-PSMB6)
-
Biorbyt antibodies for PSMB6
-
Boster Bio Antibodies for PSMB6
-
Custom Antibody ServicesProSci Antibodies for PSMB6
-
Santa Cruz Biotechnology (SCBT) Antibodies for PSMB6
- Sino Biological Antibodies for PSMB6
Protein products for research
-
OriGene Purified Proteins for PSMB6
- Search Origene for MassSpec and Protein Over-expression Lysates for PSMB6
- Origene Custom Protein Services for PSMB6
- Sino Biological Recombinant Proteins for PSMB6
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for PSMB6
-
Abcam proteins for PSMB6
Assay products for research
- antibodies-online: Show 6 available PSMB6 Elisa Kits ranked by validation data
- Compare Top PSMB6 Elisa Kits
-
Quality Products:
Domains & Families for PSMB6 Gene
Gene Families for PSMB6 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for PSMB6 Gene
- InterPro:
- Blocks:
-
- Proteasome B-type subunit
- ProtoNet:
Suggested Antigen Peptide Sequences for PSMB6 Gene
- GenScript: Design optimal peptide antigens:
-
- Proteasome subunit Y (PSB6_HUMAN)
- Proteasome subunit beta type (Q6IAT9_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P28072- Family:
-
- Belongs to the peptidase T1B family.
Function for PSMB6 Gene
Molecular function for PSMB6 Gene
- UniProtKB/Swiss-Prot Function:
- Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB6 displays a peptidylglutamyl-hydrolizing activity also termed postacidic or caspase-like activity, meaning that the peptides bond hydrolysis occurs directly after acidic residues.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=Cleavage of peptide bonds with very broad specificity.; EC=3.4.25.1; Evidence={ECO:0000269|PubMed:27176742};.
- UniProtKB/Swiss-Prot Induction:
- Down-regulated by IFNG/IFN-gamma (at protein level). Up-regulated in anaplastic thyroid cancer cell lines.
- GENATLAS Biochemistry:
- multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,beta type 1,subunit delta/Y ,25 kDa
Enzyme Numbers (IUBMB) for PSMB6 Gene
Phenotypes From GWAS Catalog for PSMB6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004175 | endopeptidase activity | NAS | 8066462 |
| GO:0004298 | threonine-type endopeptidase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 14733938 |
| GO:0008233 | peptidase activity | IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for PSMB6 Gene
- GenomeRNAi human phenotypes for PSMB6:
-
- Decreased hepcidin::fluc mRNA expression
- Decreased viability
- no effect
- Synthetic lethal with Ras
- Decreased vaccinia virus (VACV) infection
- Reduced mammosphere formation
- shRNA abundance <= 25%
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Decreased viability (cell death)
- Increased shRNA abundance (Z-score > 2)
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased homologous recombination repair frequency
- Decreased viability in colon lineage
- Decreased shRNA abundance (Z-score < -2)
- Increased ionizing radiation sensitivity
- Decreased viability of wild-type and TP53 knockout cells, decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Increased G2M DNA content
- Decreased replication of vaccinia virus (VACV)
- Decreased HIV-1 infection
- Downregulation of NFkappaB pathway
- G2 arrest
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PSMB6 - Starting at $85 >
- * PSMB6 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PSMB6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PSMB6
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSMB6
miRNA for PSMB6 Gene
- miRTarBase miRNAs that target PSMB6
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PSMB6
- Browse OriGene Inhibitory RNA Products For PSMB6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMB6
Clone products for research
- Applied Biological Materials (abm): Clones for PSMB6 - Starting at $45 >
- * PSMB6 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for PSMB6
- Addgene plasmids for PSMB6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PSMB6
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMB6 Gene
Localization for PSMB6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PSMB6 Gene
- Cytoplasm. Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 4 |
| golgi apparatus | 2 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
- Cytosol (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000502 | proteasome complex | IEA,IDA | 17323924 |
| GO:0005634 | nucleus | IEA,IBA | 21873635 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA,IBA | 21873635 |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for PSMB6 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | CDK-mediated phosphorylation and removal of Cdc6 |
.93
.93
|
.80
.80
.78
.70
.47
.31
|
| 2 | RET signaling |
.92
|
.92
|
| 3 | Chks in Checkpoint Regulation |
Chks in Checkpoint Regulation
.59
G2-M Phase Transition
.59
Estrogen-mediated S-Phase Entry
.55
|
SREBP Proteolysis
.43
DNA Repair Mechanisms
.32
Parkinson's Disease Pathway
.31
|
| 4 | HIV Life Cycle |
.64
|
.45
|
| 5 | Pathways of neurodegeneration - multiple diseases | ||
Pathways by source for PSMB6 Gene
1 Sino Biological pathway for PSMB6 Gene
1 BioSystems pathway for PSMB6 Gene
8 KEGG pathways for PSMB6 Gene
4 GeneGo (Thomson Reuters) pathways for PSMB6 Gene
- Immune response Antigen presentation by MHC class I
- Regulation of degradation of deltaF508 CFTR in CF
- Regulation of degradation of wt-CFTR
- Transcription Ligand-Dependent Transcription of Retinoid-Target genes
17 Qiagen pathways for PSMB6 Gene
- CDK5 Pathway
- Chks in Checkpoint Regulation
- DNA Repair Mechanisms
- Estrogen-mediated S-Phase Entry
- G2-M Phase Transition
Interacting Proteins for PSMB6 Gene
Selected Interacting proteins:
P28072-PSB6_HUMAN
ENSP00000270586
for PSMB6 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for PSMB6
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
| GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
| GO:0006508 | proteolysis | IEA | -- |
No data available for SIGNOR curated interactions for PSMB6 Gene
Drugs & Compounds for PSMB6 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Bortezomib | Approved, Investigational | Pharma | inhibitor, other | Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors | 926 | |
| carfilzomib | Approved, Investigational | Pharma | other, Inhibitor | Other, 20S Proteasome Inhibitor | 0 | |
| (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE | Experimental | Pharma | Target | 0 |
Transcripts for PSMB6 Gene
mRNA/cDNA for PSMB6 Gene
- 2 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000270586 824 nts (view in UCSC)
- ENST00000571309 583 nts (view in UCSC)
- ENST00000575079 583 nts (view in UCSC)
- ENST00000575643 666 nts (view in UCSC)
- ENST00000614486 871 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PSMB6 - Starting at $85 >
- * PSMB6 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PSMB6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PSMB6
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSMB6
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PSMB6
- Browse OriGene Inhibitory RNA Products For PSMB6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMB6
Clone products for research
- Applied Biological Materials (abm): Clones for PSMB6 - Starting at $45 >
- * PSMB6 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for PSMB6
- Addgene plasmids for PSMB6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PSMB6
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||
| SP4: |
Relevant External Links for PSMB6 Gene
- GeneLoc Exon Structure for
- PSMB6
Expression for PSMB6 Gene
This gene is overexpressed in Liver, secretome (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMB6 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PSMB6
SOURCE GeneReport for Unigene cluster for PSMB6 Gene:
Hs.77060Evidence on tissue expression from TISSUES for PSMB6 Gene
- Nervous system(4.9)
- Liver(3.6)
- Lung(3.4)
- Heart(2.8)
- Muscle(2.8)
- Kidney(2.8)
- Skin(2.7)
- Spleen(2.5)
- Intestine(2.5)
- Pancreas(2.4)
- Lymph node(2.3)
- Blood(2.3)
- Bone marrow(2.2)
- Eye(2.2)
- Stomach(2.2)
- Thyroid gland(2.1)
Primer products for research
-
OriGene qPCR primer pairs for PSMB6
-
OriGene qPCR primer pairs and template standards for PSMB6
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMB6 Gene
Orthologs for PSMB6 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PSMB6 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PSMB6 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PSMB6 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Psmb6 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | PSMB6 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | psmb6 30 |
|
||
| MGC75674 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | psmb6 30 31 |
|
OneToOne | |
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8481 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | l(2)05070 32 |
|
|
|
| Prosbeta1 31 |
|
OneToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | pbs-1 31 |
|
OneToMany | |
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AAL172C 30 |
|
||
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F12936g 30 |
|
||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PRE3 30 31 33 |
|
OneToMany | |
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | PBA1 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os02g0770000 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.5051 31 |
|
OneToMany | |
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU09290 30 |
|
||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | pre3 30 |
|
||
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.5142 30 |
|
- Species where no ortholog for PSMB6 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rat (Rattus norvegicus)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for PSMB6 Gene
- ENSEMBL:
- Gene Tree for PSMB6 (if available)
- TreeFam:
- Gene Tree for PSMB6 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PSMB6: view image
Paralogs for PSMB6 Gene
Paralogs for PSMB6 Gene
(6) SIMAP similar genes for PSMB6 Gene using alignment to 3 proteins:
- PSB6_HUMAN
- I3L3X7_HUMAN
- Q6IAT9_HUMAN
Variants for PSMB6 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PSMB6 Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs2304974 | - |
p.Pro107Ala |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
58.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.68;
57.10% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PSMB6 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PSMB6
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMB6 Gene
Disorders for PSMB6 Gene
Additional Disease Information for PSMB6
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No disorders were found for PSMB6 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMB6 Gene
Publications for PSMB6 Gene
- cDNA cloning and interferon gamma down-regulation of proteasomal subunits X and Y. (PMID: 8066462) Akiyama K … Ichihara A (Science (New York, N.Y.) 1994) 2 3 4
- The primary structures of four subunits of the human, high-molecular-weight proteinase, macropain (proteasome), are distinct but homologous. (PMID: 1888762) DeMartino GN … Slaughter CA (Biochimica et biophysica acta 1991) 2 3 4
- An atomic structure of the human 26S proteasome. (PMID: 27428775) Huang X … Shi Y (Nature structural & molecular biology 2016) 3 4
- Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X … Huang L (Biochemistry 2007) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
ExternalLinks
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Sources for PSMB6 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB