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The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
PSMB6 (Proteasome 20S Subunit Beta 6) is a Protein Coding gene. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Antigen processing-Cross presentation. Gene Ontology (GO) annotations related to this gene include endopeptidase activity and threonine-type endopeptidase activity. An important paralog of this gene is PSMB9.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH17J004795 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE CraniofacialAtlas | 600.7 | +0.3 | 257 | 2 | CREB1 GATAD2A PRDM10 ZNF629 TFE3 SIX5 KDM1A ZNF692 POLR2A RCOR2 | HE856254 PSMB6 ZNF594 PLD2 ENSG00000261879 ENSG00000262165 ENSG00000262227 ZZEF1 PELP1 C17orf107 | |
GH17J004843 | Promoter/Enhancer | 1 | FANTOM5 Ensembl ENCODE dbSUPER | 11.9 | +48.7 | 48685 | 2.2 | NFE2 | ARRB2 ZMYND15 CXCL16 C17orf107 PLD2 PSMB6 GLTPD2 VMO1 RPS12P29 LOC101559451 | |
GH17J004842 | Enhancer | 0.3 | dbSUPER | 11.9 | +46.7 | 46661 | 1.1 | CEBPB | CHRNE PLD2 PSMB6 GLTPD2 VMO1 ENO3 PFN1 CAMTA2 MINK1 lnc-CHRNE-4 | |
GH17J004801 | Enhancer | 0.2 | FANTOM5 | 0.4 | +5.2 | 5248 | 0.4 | piR-57460-270 ENSG00000262165 MINK1 ZNF232 KIF1C PSMB6 lnc-VMO1-2 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004175 | endopeptidase activity | IEA,NAS | 8066462 |
GO:0004298 | threonine-type endopeptidase activity | IEA | -- |
GO:0005515 | protein binding | IPI | 14733938 |
GO:0008233 | peptidase activity | IEA | -- |
GO:0016787 | hydrolase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000502 | proteasome complex | IEA,IDA | 17323924 |
GO:0005634 | nucleus | IEA,IBA | 21873635 |
GO:0005654 | nucleoplasm | IDA,TAS | -- |
GO:0005737 | cytoplasm | IEA,IBA | 21873635 |
GO:0005829 | cytosol | IDA,TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Regulation of activated PAK-2p34 by proteasome mediated degradation |
.93
.93
|
.80
.79
.78
.69
.47
|
2 | RET signaling |
.92
|
.92
|
3 | Chks in Checkpoint Regulation |
Chks in Checkpoint Regulation
.58
G2-M Phase Transition
.58
Estrogen-mediated S-Phase Entry
.54
|
SREBP Proteolysis
.42
DNA Repair Mechanisms
.31
Parkinson's Disease Pathway
.30
|
4 | HIV Life Cycle |
.65
|
.45
|
5 | Parkinson disease |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000165 | MAPK cascade | TAS | -- |
GO:0000209 | protein polyubiquitination | TAS | -- |
GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
GO:0006508 | proteolysis | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Bortezomib | Approved, Investigational | Pharma | inhibitor, other | Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors | 910 | |
carfilzomib | Approved, Investigational | Pharma | other, Inhibitor | Other, 20S Proteasome Inhibitor | 0 | |
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE | Experimental | Pharma | Target | 0 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||
SP4: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PSMB6 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PSMB6 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PSMB6 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Psmb6 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Lizard (Anolis carolinensis) |
Reptilia | PSMB6 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | psmb6 30 |
|
||
MGC75674 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | psmb6 30 31 |
|
OneToOne | |
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8481 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | l(2)05070 32 |
|
|
|
Prosbeta1 31 |
|
OneToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | pbs-1 31 |
|
OneToMany | |
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AAL172C 30 |
|
||
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F12936g 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PRE3 30 31 33 |
|
OneToMany | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | PBA1 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os02g0770000 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.5051 31 |
|
OneToMany | |
Bread mold (Neurospora crassa) |
Ascomycetes | NCU09290 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | pre3 30 |
|
||
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.5142 30 |
|
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs2304974 | - | p.Pro107Ala |
No disorders were found for PSMB6 Gene.