The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiq... See more...

Aliases for PSMB6 Gene

Aliases for PSMB6 Gene

  • Proteasome Subunit Beta 6 2 3 5
  • Proteasome (Prosome, Macropain) Subunit, Beta Type, 6 2 3
  • Multicatalytic Endopeptidase Complex Delta Chain 3 4
  • Proteasome Subunit Beta Type-6 3 4
  • Proteasome Delta Chain 3 4
  • Macropain Delta Chain 3 4
  • Proteasome Subunit Y 3 4
  • EC 3.4.25.1 4 54
  • LMPY 3 4
  • Y 3 4
  • PSY Large Multifunctional Protease Y 3
  • Proteasome Catalytic Subunit 1 3
  • Proteasome Subunit Delta 3
  • DELTA 3

External Ids for PSMB6 Gene

Previous GeneCards Identifiers for PSMB6 Gene

  • GC17P005126
  • GC17P004650
  • GC17P004906
  • GC17P004646
  • GC17P004699
  • GC17P004587

Summaries for PSMB6 Gene

Entrez Gene Summary for PSMB6 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for PSMB6 Gene

PSMB6 (Proteasome Subunit Beta 6) is a Protein Coding gene. Among its related pathways are Cellular Senescence (REACTOME) and TCR signaling (REACTOME). Gene Ontology (GO) annotations related to this gene include endopeptidase activity and threonine-type endopeptidase activity. An important paralog of this gene is PSMB9.

UniProtKB/Swiss-Prot Summary for PSMB6 Gene

  • Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB6 displays a peptidylglutamyl-hydrolizing activity also termed postacidic or caspase-like activity, meaning that the peptides bond hydrolysis occurs directly after acidic residues.

Gene Wiki entry for PSMB6 Gene

Additional gene information for PSMB6 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSMB6 Gene

Genomics for PSMB6 Gene

GeneHancer (GH) Regulatory Elements for PSMB6 Gene

Promoters and enhancers for PSMB6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J004795 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 750.6 +0.3 257 2 SIN3A SIX5 ZBTB6 LCORL FOXA1 RBPJ POLR2A NR2F6 ATF1 CREB1 HE856254 PSMB6 ZZEF1 ZNF594 PLD2 ENSG00000261879 ENSG00000262165 ENSG00000262227 DHX33-DT NUP88
GH17J004843 Promoter/Enhancer 1 FANTOM5 Ensembl ENCODE dbSUPER 11.9 +48.7 48685 2.2 NFE2 ARRB2 ZMYND15 CXCL16 C17orf107 PLD2 PSMB6 ENSG00000213939 VMO1 GLTPD2 LOC101559451
GH17J004842 Enhancer 0.3 dbSUPER 11.9 +46.7 46661 1.1 CEBPB CHRNE PLD2 PSMB6 GLTPD2 VMO1 ENO3 PFN1 CAMTA2 lnc-CHRNE-4 MINK1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSMB6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PSMB6 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • FOXD1
  • Lmo2
  • LyF-1
  • Olf-1
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for PSMB6 Gene

Genomic Locations for PSMB6 Gene
chr17:4,796,144-4,798,503
(GRCh38/hg38)
Size:
2,360 bases
Orientation:
Plus strand
chr17:4,699,439-4,701,790
(GRCh37/hg19)
Size:
2,352 bases
Orientation:
Plus strand

Genomic View for PSMB6 Gene

Genes around PSMB6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMB6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMB6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMB6 Gene

Proteins for PSMB6 Gene

  • Protein details for PSMB6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28072-PSB6_HUMAN
    Recommended name:
    Proteasome subunit beta type-6
    Protein Accession:
    P28072
    Secondary Accessions:
    • Q96J55

    Protein attributes for PSMB6 Gene

    Size:
    239 amino acids
    Molecular mass:
    25358 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.
    • (Microbial infection) Interacts with HIV-1 protein Tat.

    Three dimensional structures from OCA and Proteopedia for PSMB6 Gene

neXtProt entry for PSMB6 Gene

Selected DME Specific Peptides for PSMB6 Gene

P28072:
  • CRSGSAAD
  • TGTTIMAV
  • YIANRVT
  • RDGSSGGV
  • ALAMERDGSSGG
  • GSGSSYIYGYVDA
  • GGSGSSY

Post-translational modifications for PSMB6 Gene

  • Ubiquitination at Lys67 and Lys230
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMB6 Gene

Domains & Families for PSMB6 Gene

Gene Families for PSMB6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PSMB6 Gene

GenScript: Design optimal peptide antigens:
  • Proteasome subunit Y (PSB6_HUMAN)
  • Proteasome subunit beta type (Q6IAT9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P28072

UniProtKB/Swiss-Prot:

PSB6_HUMAN :
  • Belongs to the peptidase T1B family.
Family:
  • Belongs to the peptidase T1B family.
genes like me logo Genes that share domains with PSMB6: view

Function for PSMB6 Gene

Molecular function for PSMB6 Gene

UniProtKB/Swiss-Prot Function:
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB6 displays a peptidylglutamyl-hydrolizing activity also termed postacidic or caspase-like activity, meaning that the peptides bond hydrolysis occurs directly after acidic residues.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Cleavage of peptide bonds with very broad specificity.; EC=3.4.25.1; Evidence=. ;.
UniProtKB/Swiss-Prot Induction:
Down-regulated by IFNG/IFN-gamma (at protein level). Up-regulated in anaplastic thyroid cancer cell lines.
GENATLAS Biochemistry:
multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,beta type 1,subunit delta/Y ,25 kDa

Enzyme Numbers (IUBMB) for PSMB6 Gene

Phenotypes From GWAS Catalog for PSMB6 Gene

Gene Ontology (GO) - Molecular Function for PSMB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IEA,NAS 8066462
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0045296 cadherin binding HDA 25468996
genes like me logo Genes that share ontologies with PSMB6: view
genes like me logo Genes that share phenotypes with PSMB6: view

Animal Model Products

CRISPR Products

miRNA for PSMB6 Gene

miRTarBase miRNAs that target PSMB6

Clone Products

  • Addgene plasmids for PSMB6

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMB6 Gene

Localization for PSMB6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMB6 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMB6 gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PSMB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IEA,IDA 17323924
GO:0005634 nucleus IBA,IEA 21873635
GO:0005654 nucleoplasm IDA,TAS --
GO:0005737 cytoplasm IBA,IEA 21873635
GO:0005829 cytosol TAS,IDA --
genes like me logo Genes that share ontologies with PSMB6: view

Pathways & Interactions for PSMB6 Gene

PathCards logo

SuperPathways for PSMB6 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 Chks in Checkpoint Regulation
.59
.59
.55
.43
.32
.31
4 HIV Life Cycle
.45
5 Class I MHC mediated antigen processing and presentation
genes like me logo Genes that share pathways with PSMB6: view

Pathways by source for PSMB6 Gene

1 KEGG pathway for PSMB6 Gene
17 Qiagen pathways for PSMB6 Gene
  • CDK5 Pathway
  • Chks in Checkpoint Regulation
  • DNA Repair Mechanisms
  • Estrogen-mediated S-Phase Entry
  • G2-M Phase Transition

Gene Ontology (GO) - Biological Process for PSMB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PSMB6: view

No data available for SIGNOR curated interactions for PSMB6 Gene

Drugs & Compounds for PSMB6 Gene

(3) Drugs for PSMB6 Gene - From: DrugBank and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 878
carfilzomib Approved, Investigational Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Experimental Pharma Target 0
genes like me logo Genes that share compounds with PSMB6: view

Transcripts for PSMB6 Gene

mRNA/cDNA for PSMB6 Gene

CRISPR Products

Clone Products

  • Addgene plasmids for PSMB6

Alternative Splicing Database (ASD) splice patterns (SP) for PSMB6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for PSMB6 Gene

GeneLoc Exon Structure for
PSMB6
ECgene alternative splicing isoforms for
PSMB6

Expression for PSMB6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSMB6 Gene

Protein differential expression in normal tissues from HIPED for PSMB6 Gene

This gene is overexpressed in Liver, secretome (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMB6 Gene



Protein tissue co-expression partners for PSMB6 Gene

NURSA nuclear receptor signaling pathways regulating expression of PSMB6 Gene:

PSMB6

SOURCE GeneReport for Unigene cluster for PSMB6 Gene:

Hs.77060

Evidence on tissue expression from TISSUES for PSMB6 Gene

  • Nervous system(4.8)
  • Liver(3.4)
  • Lung(3.3)
  • Heart(2.3)
  • Muscle(2.2)
  • Kidney(2.1)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with PSMB6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMB6 Gene

Orthologs for PSMB6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMB6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMB6 33 32
  • 99.3 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PSMB6 33 32
  • 89.92 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PSMB6 33 32
  • 89.78 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Psmb6 17 33 32
  • 89.64 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 82 (a)
OneToMany
-- 33
  • 57 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia PSMB6 33
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psmb6 32
  • 75.52 (n)
MGC75674 32
zebrafish
(Danio rerio)
Actinopterygii psmb6 33 32 32
  • 75.04 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8481 32
fruit fly
(Drosophila melanogaster)
Insecta l(2)05070 34
  • 57 (a)
Prosbeta1 33
  • 54 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pbs-1 33
  • 40 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL172C 32
  • 60.1 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F12936g 32
  • 57.19 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRE3 35 33 32
  • 54.06 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons PBA1 32
  • 54.15 (n)
rice
(Oryza sativa)
Liliopsida Os02g0770000 32
  • 55.39 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5051 33
  • 63 (a)
OneToMany
Cin.5142 32
bread mold
(Neurospora crassa)
Ascomycetes NCU09290 32
  • 58.38 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pre3 32
  • 56.6 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5142 32
Species where no ortholog for PSMB6 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSMB6 Gene

ENSEMBL:
Gene Tree for PSMB6 (if available)
TreeFam:
Gene Tree for PSMB6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PSMB6: view image

Paralogs for PSMB6 Gene

(6) SIMAP similar genes for PSMB6 Gene using alignment to 3 proteins:

  • PSB6_HUMAN
  • I3L3X7_HUMAN
  • Q6IAT9_HUMAN
genes like me logo Genes that share paralogs with PSMB6: view

Variants for PSMB6 Gene

Sequence variations from dbSNP and Humsavar for PSMB6 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1001687886 -- 4,797,033(+) G/A intron_variant
rs1001789495 -- 4,797,517(+) G/A coding_sequence_variant, missense_variant
rs1002160968 -- 4,798,771(+) C/T downstream_transcript_variant
rs1002355072 -- 4,794,549(+) T/C upstream_transcript_variant
rs1002742017 -- 4,796,051(+) G/A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PSMB6 Gene

Variant ID Type Subtype PubMed ID
nsv574273 CNV gain 21841781
nsv833346 CNV loss 17160897
nsv833347 CNV loss 17160897

Variation tolerance for PSMB6 Gene

Residual Variation Intolerance Score: 58.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.68; 57.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PSMB6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMB6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMB6 Gene

Disorders for PSMB6 Gene

Additional Disease Information for PSMB6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PSMB6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMB6 Gene

Publications for PSMB6 Gene

  1. cDNA cloning and interferon gamma down-regulation of proteasomal subunits X and Y. (PMID: 8066462) Akiyama K … Ichihara A (Science (New York, N.Y.) 1994) 2 3 4 56
  2. The primary structures of four subunits of the human, high-molecular-weight proteinase, macropain (proteasome), are distinct but homologous. (PMID: 1888762) DeMartino GN … Slaughter CA (Biochimica et biophysica acta 1991) 2 3 4 56
  3. An atomic structure of the human 26S proteasome. (PMID: 27428775) Huang X … Shi Y (Nature structural & molecular biology 2016) 3 4 56
  4. Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X … Huang L (Biochemistry 2007) 3 4 56
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56

Products for PSMB6 Gene

Sources for PSMB6 Gene