PSMB6 Gene (Protein Coding)

Proteasome Subunit Beta 6

GCID:: GC17P004796

GIFtS:: 44

Genes Participants

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiq... See more...

Aliases for PSMB6 Gene

Proteasome Subunit Beta 6 ² ³ ⁵
Proteasome (Prosome, Macropain) Subunit, Beta Type, 6 ² ³
Multicatalytic Endopeptidase Complex Delta Chain ³ ⁴
Proteasome Subunit Beta Type-6 ³ ⁴
Proteasome Delta Chain ³ ⁴
Macropain Delta Chain ³ ⁴
Proteasome Subunit Y ³ ⁴

EC 3.4.25.1 ⁴ ⁵⁴
LMPY ³ ⁴
Y ³ ⁴
PSY Large Multifunctional Protease Y ³
Proteasome Catalytic Subunit 1 ³
Proteasome Subunit Delta ³
DELTA ³

External Ids for PSMB6 Gene

HGNC: 9543
Entrez Gene: 5694
Ensembl: ENSG00000142507
OMIM: 600307
UniProtKB: P28072

Previous GeneCards Identifiers for PSMB6 Gene

GC17P005126
GC17P004650
GC17P004906
GC17P004646
GC17P004699
GC17P004587

Search aliases for PSMB6 gene in PubMed and other databases

Summaries for PSMB6 Gene

Entrez Gene Summary for PSMB6 Gene

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for PSMB6 Gene

PSMB6 (Proteasome Subunit Beta 6) is a Protein Coding gene. Among its related pathways are Cellular Senescence (REACTOME) and TCR signaling (REACTOME). Gene Ontology (GO) annotations related to this gene include endopeptidase activity and threonine-type endopeptidase activity. An important paralog of this gene is PSMB9.

UniProtKB/Swiss-Prot Summary for PSMB6 Gene

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB6 displays a peptidylglutamyl-hydrolizing activity also termed postacidic or caspase-like activity, meaning that the peptides bond hydrolysis occurs directly after acidic residues.
- PSB6_HUMAN,P28072

Gene Wiki entry for PSMB6 Gene

Additional gene information for PSMB6 Gene

Search for PSMB6 at DataMed
Search for PSMB6 at HumanCyc

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSMB6 Gene

Genomics for PSMB6 Gene

GeneHancer (GH) Regulatory Elements for PSMB6 Gene

Promoters and enhancers for PSMB6 Gene

GeneHancer (GH) Identifier	GH Type	GH Score	GH Sources	Gene Association Score	Total Score	TSS distance (kb)	Number of Genes Away	Size (kb)	Transcription Factor Binding Sites
GH17J004795	Promoter/Enhancer	2	EPDnew Ensembl ENCODE CraniofacialAtlas	750.6	+0.3	257	2	SIN3A SIX5 ZBTB6 LCORL FOXA1 RBPJ POLR2A NR2F6 ATF1 CREB1	HE856254 PSMB6 ZZEF1 ZNF594 PLD2 ENSG00000261879 ENSG00000262165 ENSG00000262227 DHX33-DT NUP88
GH17J004843	Promoter/Enhancer	1	FANTOM5 Ensembl ENCODE dbSUPER	11.9	+48.7	48685	2.2	NFE2	ARRB2 ZMYND15 CXCL16 C17orf107 PLD2 PSMB6 ENSG00000213939 VMO1 GLTPD2 LOC101559451
GH17J004842	Enhancer	0.3	dbSUPER	11.9	+46.7	46661	1.1	CEBPB	CHRNE PLD2 PSMB6 GLTPD2 VMO1 ENO3 PFN1 CAMTA2 lnc-CHRNE-4 MINK1

- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSMB6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PSMB6 gene promoter:

AP-1
ATF-2
c-Jun
FOXD1
Lmo2
LyF-1
Olf-1
STAT1
STAT1alpha
STAT1beta

Genomic Locations for PSMB6 Gene

chr17:4,796,144-4,798,503: (GRCh38/hg38)

Size:: 2,360 bases
Orientation:: Plus strand

chr17:4,699,439-4,701,790: (GRCh37/hg19)

Size:: 2,352 bases
Orientation:: Plus strand

Genomic View for PSMB6 Gene

Genes around PSMB6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:

17p13.2 by HGNC
17p13.2 by Entrez Gene
17p13.2 by Ensembl

PSMB6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

Genomic Location for PSMB6 Gene — Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PSMB6 Gene

NC_000017.11

Proteins for PSMB6 Gene

Protein details for PSMB6 Gene (UniProtKB/Swiss-Prot)
Protein Symbol:

P28072-PSB6_HUMAN

Recommended name:

Proteasome subunit beta type-6

Protein Accession:

P28072

Secondary Accessions:
- Q96J55
Protein attributes for PSMB6 Gene
Size:

239 amino acids

Molecular mass:

25358 Da
Quaternary structure:
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.

(Microbial infection) Interacts with HIV-1 protein Tat.
Three dimensional structures from OCA and Proteopedia for PSMB6 Gene
- 4R3O (3D)
- 4R67 (3D)
- 5A0Q (3D)
- 5GJQ (3D)
- 5GJR (3D)
- 5L4G (3D)

neXtProt entry for PSMB6 Gene

Protein Expression for PSMB6 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for PSMB6 Gene

P28072:

CRSGSAAD
TGTTIMAV
YIANRVT
RDGSSGGV
ALAMERDGSSGG
GSGSSYIYGYVDA
GGSGSSY

Post-translational modifications for PSMB6 Gene

Ubiquitination at Lys67 and Lys230
- NX_P28072 (NX_P28072-1)
Modification sites at PhosphoSitePlus
- P28072

Other Protein References for PSMB6 Gene

ENSEMBL proteins:

REFSEQ proteins:

Antibody Products

Atlas Antibodies Anti-PSMB6 Antibody (HPA023312) and Anti-PSMB6 Antibody (HPA063656)

Creative Diagnostics Anti-PSMB6 (full length) polyclonal antibody

Creative Biolabs

OriGene Antibodies for PSMB6
- TA342170
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Novus Biologicals Antibodies for PSMB6

Abcam antibodies for PSMB6
- Proteasome 20S beta 6

Invitrogen Antibodies for PSMB6 (AFLGC-PSMB6)

antibodies-online: Show 7 available PSMB6 Antibodies ranked by validation data
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Boster Bio Antibodies for PSMB6
- M07705

Santa Cruz Biotechnology (SCBT) Antibodies for PSMB6
- PSMB6 (JQ-3)
- PSMB6 (B-6)

Sino Biological Antibodies for PSMB6

Protein Products

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Novus Biologicals proteins and lysates for PSMB6

Sino Biological Recombinant Proteins for PSMB6
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ProSpec Recombinant Proteins for PSMB6

antibodies-online: Show 11 available PSMB6 Proteins ranked by validation data
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Search for PSMB6 Proteins at ProSci

Abcam proteins for PSMB6
- Proteasome 20S beta 6

Assay Products

Aviva Systems Biology PSMb6 ELISA Kit (Human) (OKDD00490) and PSMB6 ELISA Kit (Human) (OKCD00993)

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Domains & Families for PSMB6 Gene

Gene Families for PSMB6 Gene

HGNC:

Proteasome

Human Protein Atlas (HPA):

Enzymes
Plasma proteins
Predicted intracellular proteins

Protein Domains for PSMB6 Gene

Blocks:

Proteasome B-type subunit

InterPro:

ProtoNet:

P28072

Suggested Antigen Peptide Sequences for PSMB6 Gene

GenScript: Design optimal peptide antigens:

Proteasome subunit Y (PSB6_HUMAN)
Proteasome subunit beta type (Q6IAT9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P28072

UniProtKB/Swiss-Prot:

PSB6_HUMAN :

Belongs to the peptidase T1B family.

Family:

Belongs to the peptidase T1B family.

Function for PSMB6 Gene

Molecular function for PSMB6 Gene

UniProtKB/Swiss-Prot Function:

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB6 displays a peptidylglutamyl-hydrolizing activity also termed postacidic or caspase-like activity, meaning that the peptides bond hydrolysis occurs directly after acidic residues.

PSB6_HUMAN,P28072

UniProtKB/Swiss-Prot CatalyticActivity:

Reaction=Cleavage of peptide bonds with very broad specificity.; EC=3.4.25.1; Evidence=. ;.

PSB6_HUMAN,P28072

UniProtKB/Swiss-Prot Induction:

Down-regulated by IFNG/IFN-gamma (at protein level). Up-regulated in anaplastic thyroid cancer cell lines.

PSB6_HUMAN,P28072

GENATLAS Biochemistry:

multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,beta type 1,subunit delta/Y ,25 kDa

PSMB6

Enzyme Numbers (IUBMB) for PSMB6 Gene

EC 3.4.25.1 ⁵⁴ ⁴

Phenotypes From GWAS Catalog for PSMB6 Gene

Gene Ontology (GO) - Molecular Function for PSMB6 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004175	endopeptidase activity	IEA,NAS	8066462
GO:0004298	threonine-type endopeptidase activity	IEA	--
GO:0008233	peptidase activity	IEA	--
GO:0016787	hydrolase activity	IEA	--
GO:0045296	cadherin binding	HDA	25468996

Phenotypes for PSMB6 Gene

GenomeRNAi human phenotypes for PSMB6:

Animal Model Products

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CRISPR Products

OriGene CRISPR knockouts for PSMB6
- KN401605
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Overview of 149 available PSMB6 gene related products
Recommended
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miRNA for PSMB6 Gene

miRTarBase miRNAs that target PSMB6

miRNA Products

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Inhibitory RNA Products

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Overview of 149 available PSMB6 gene related products
Recommended
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Search Santa Cruz Biotechnology (SCBT) for PSMB6 siRNA/shRNA

Clone Products

OriGene clones in human,mouse,rat for PSMB6
- MC200922
- RN205587
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- SC200557
- SC322188
- SC334506
OriGene ORF clones in human,mouse,rat for PSMB6
- MG202087
- MR202087
- MR202087L3
- MR202087L3V
- MR202087L4
- MR202087L4V
- RC201605
- RC201605L1
- RC201605L1V
- RC201605L2
- RC201605L2V
- RC201605L3
- RC201605L3V
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- RR205587
- RR205587L3
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Sino Biological Human cDNA Clone for PSMB6

Addgene plasmids for PSMB6

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Overview of 149 available PSMB6 gene related products
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orf clones - Search for available PSMB6 ORF products
Overview of 149 available PSMB6 gene related products
Recommended
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Cell Line Products

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Search Horizon for Cell Lines for PSMB6

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMB6 Gene

Localization for PSMB6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMB6 Gene

Cytoplasm. Nucleus.

P28072-PSB6_HUMAN

Subcellular locations from

COMPARTMENTS

Compartment	Confidence
nucleus	5
cytosol	5
golgi apparatus	2
endoplasmic reticulum	1

Subcellular locations from the

Human Protein Atlas (HPA)

Cytosol (3)
Nucleoplasm (3)

See all subcellular structures

Gene Ontology (GO) - Cellular Components for PSMB6 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000502	proteasome complex	IEA,IDA	17323924
GO:0005634	nucleus	IBA,IEA	21873635
GO:0005654	nucleoplasm	IDA,TAS	--
GO:0005737	cytoplasm	IBA,IEA	21873635
GO:0005829	cytosol	TAS,IDA	--

Pathways & Interactions for PSMB6 Gene

SuperPathways for PSMB6 Gene

	SuperPathway	Contained pathways
1	CDK-mediated phosphorylation and removal of Cdc6	Activation of APC/C and APC/C-Cdc20 mediated degradation of mitotic proteins .95 Cdc20-Phospho-APC/C mediated degradation of Cyclin A .95 Autodegradation of the E3 ubiquitin ligase COP1 .95 Stabilization of p53 .95 Regulation of activated PAK-2p34 by proteasome mediated degradation .94 Regulation of Apoptosis .94 CDK-mediated phosphorylation and removal of Cdc6 .94 Ubiquitin-dependent degradation of Cyclin D .94 Ubiquitin-dependent degradation of Cyclin D1 .94 Orc1 removal from chromatin .94 Regulation of DNA replication .94 Switching of origins to a post-replicative state .94 Cyclin A-Cdk2-associated events at S phase entry .93 Cyclin E associated events during G1/S transition .93 APC/C-Cdc20 mediated degradation of Securin .93 APC/C-Cdh1 mediated degradation of Cdc20 and other APC/C-Cdh1 targeted proteins in late mitosis/early G1 .93 APC/C-mediated degradation of cell cycle proteins .93 Regulation of APC/C activators between G1/S and early anaphase .93 Regulation of mitotic cell cycle .93 DNA Replication .93 Synthesis of DNA .93 Vpu mediated degradation of CD4 .93 Autodegradation of Cdh1 by Cdh1-APC/C .91 SCF-beta-TrCP mediated degradation of Emi1 .91 p53-Independent DNA Damage Response .91 p53-Independent G1/S DNA damage checkpoint .91 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A .91 ABC transporter disorders .91 Disorders of transmembrane transporters .91 Defective CFTR causes cystic fibrosis .90 Assembly of the pre-replicative complex .90 Hedgehog ligand biogenesis .90 Hh mutants abrogate ligand secretion .90 APC/C-Cdc20 mediated degradation of mitotic proteins .89 APC-Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint .89 Vif-mediated degradation of APOBEC3G .89 Degradation of GLI1 by the proteasome .89 Degradation of GLI2 by the proteasome .89 GLI3 is processed to GLI3R by the proteasome .89 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis .88	Degradation of AXIN .88 Cellular response to hypoxia .87 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha .87 Regulation of Hypoxia-inducible Factor (HIF) by oxygen .87 CDT1 association with the CDC6-ORC-origin complex .87 Hh mutants that dont undergo autocatalytic processing are degraded by ERAD .87 AUF1 (hnRNP D0) binds and destabilizes mRNA .86 p53-Dependent G1 DNA Damage Response .86 p53-Dependent G1/S DNA damage checkpoint .86 SCF(Skp2)-mediated degradation of p27/p21 .86 Removal of licensing factors from origins .86 NIK-->noncanonical NF-kB signaling .85 Dectin-1 mediated noncanonical NF-kB signaling .84 G1/S DNA Damage Checkpoints .84 Degradation of DVL .83 Cross-presentation of soluble exogenous antigens (endosomes) .82 The role of GTSE1 in G2/M progression after G2 checkpoint .81 Regulation of ornithine decarboxylase (ODC) .81 DNA Replication Pre-Initiation .80 M/G1 Transition .80 Proteasome .78 S Phase .78 Activation of NF-kappaB in B cells .77 Asymmetric localization of PCP proteins .74 FCERI mediated NF-kB activation .72 Regulation of RAS by GAPs .70 PCP/CE pathway .70 Beta-catenin independent WNT signaling .64 Degradation of beta-catenin by the destruction complex .64 Regulation of mRNA stability by proteins that bind AU-rich elements .63 Metabolism of polyamines .60 ABC-family proteins mediated transport .58 TNFR2 non-canonical NF-kB pathway .58 MAPK6/MAPK4 signaling .57 Proteasome Degradation .56 UCH proteinases .47 Canonical Wnt Pathway .32 Apoptosis .31 Programmed Cell Death .31
2	RET signaling	Frs2-mediated activation .95 GRB2 events in EGFR signaling .95 MAPK1/MAPK3 signaling .95 Prolonged ERK activation events .95 RAF/MAP kinase cascade .95 SHC1 events in EGFR signaling .95 Signaling by Leptin .95 SOS-mediated signalling .95 VEGFR2 mediated cell proliferation .95 ARMS-mediated activation .95 Signalling to ERKs .95 Signalling to p38 via RIT and RIN .95 Signalling to RAS .95 Interleukin receptor SHC signaling .95 Interleukin-3, 5 and GM-CSF signaling .94 Interleukin-2 signaling .94 Downstream signal transduction .94 Signaling by PDGF .94 DAP12 signaling .92	RET signaling .92 Insulin receptor signalling cascade .92 Signaling by Insulin receptor .92 IRS-mediated signalling .91 Signaling by EGFR .90 FCERI mediated MAPK activation .90 IGF1R signaling cascade .90 IRS-related events triggered by IGF1R .90 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) .90 DAP12 interactions .89 NCAM signaling for neurite out-growth .89 NGF signalling via TRKA from the plasma membrane .87 MAPK family signaling cascades .87 Signaling by SCF-KIT .85 Signalling by NGF .81 Fc epsilon receptor (FCERI) signaling .79 VEGFA-VEGFR2 Pathway .78 Signaling by VEGF .76 Gastrin-CREB signalling pathway via PKC and MAPK .55
3	Chks in Checkpoint Regulation	Chks in Checkpoint Regulation .59 G2-M Phase Transition .59 Estrogen-mediated S-Phase Entry .55	SREBP Proteolysis .43 DNA Repair Mechanisms .32 Parkinson's Disease Pathway .31
4	HIV Life Cycle	HIV Infection .64 Infectious disease .61 Host Interactions of HIV factors .57	Disease .45 Diseases of signal transduction .43
5	Class I MHC mediated antigen processing and presentation	Antigen processing- Ubiquitination and Proteasome degradation .83 Class I MHC mediated antigen processing and presentation .83	Adaptive Immune System .45

Pathways by source for PSMB6 Gene

1 Sino Biological pathway for PSMB6 Gene

Canonical Wnt Pathway

1 BioSystems pathway for PSMB6 Gene

Proteasome Degradation

164 Reactome pathways for PSMB6 Gene

1 KEGG pathway for PSMB6 Gene

Proteasome

4 GeneGo (Thomson Reuters) pathways for PSMB6 Gene

17 Qiagen pathways for PSMB6 Gene

CDK5 Pathway
Chks in Checkpoint Regulation
DNA Repair Mechanisms
Estrogen-mediated S-Phase Entry
G2-M Phase Transition

Interacting Proteins for PSMB6 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)

Selected Interacting proteins: P28072-PSB6_HUMAN ENSP00000270586 for PSMB6 Gene via MINT STRING IID

Symbol	External ID(s)	Details
MDM2	Q00987 ²⁰ ¹²⁹ ENSP00000258149 ²¹	MINT-8378851 STRING: ENSP00000258149 IID: # exp=1
POMP	Q9Y244 ²⁰ ¹²⁹ ENSP00000370222 ²¹	MINT-6176318 STRING: ENSP00000370222 IID: # exp=2 # pred=1
PSMA6	P60900 ²⁰ ¹²⁹ ENSP00000261479 ²¹	MINT-6176080 STRING: ENSP00000261479 IID: # exp=4 # pred=5
PSMA7	O14818 ²⁰ ¹²⁹ ENSP00000359910 ²¹	MINT-6176676 STRING: ENSP00000359910 IID: # exp=4 # pred=2
PSMB7	Q99436 ²⁰ ¹²⁹ ENSP00000259457 ²¹	MINT-6176297 STRING: ENSP00000259457 IID: # exp=8 # pred=5

GPS-Prot Interaction Network for PSMB6

Gene Ontology (GO) - Biological Process for PSMB6 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000165	MAPK cascade	TAS	--
GO:0000209	protein polyubiquitination	TAS	--
GO:0002223	stimulatory C-type lectin receptor signaling pathway	TAS	--
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	TAS	--
GO:0006508	proteolysis	IEA	--

No data available for SIGNOR curated interactions for PSMB6 Gene

Drugs & Compounds for PSMB6 Gene

(3) Drugs for PSMB6 Gene - From: DrugBank and DGIdb

Name	Status	Disease Links	Group	Role	Mechanism of Action	Clinical Trials
Bortezomib	Approved, Investigational	MalaCards Medline Plus	Pharma	inhibitor, other	Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors	878
carfilzomib	Approved, Investigational	MalaCards Medline Plus	Pharma	other, Inhibitor	Other, 20S Proteasome Inhibitor	0
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE	Experimental	MalaCards Medline Plus	Pharma	Target		0

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Transcripts for PSMB6 Gene

mRNA/cDNA for PSMB6 Gene

(2) REFSEQ mRNAs :

(10) Additional mRNA sequences :

(614) Selected AceView cDNA sequences:

(5) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

ENST00000270586 824 bps (ENST00000270586.7)
ENST00000571309 583 bps (ENST00000571309.1)
ENST00000575079 583 bps (ENST00000575079.1)
ENST00000575643 666 bps (ENST00000575643.1)
ENST00000614486 871 bps (ENST00000614486.4)

CRISPR Products

OriGene CRISPR knockouts for PSMB6
- KN401605
- KN514104

Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PSMB6

genomics-online: gRNA clones - Search for available PSMB6 gRNA products
Overview of 149 available PSMB6 gene related products
Recommended
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- pGEM-T
- pENTR221

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miRNA Products

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Inhibitory RNA Products

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genomics-online: shRNA clones - Search for available PSMB6 shRNA products
Overview of 149 available PSMB6 gene related products
Recommended
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- pDNR-LIB
- pUC19
- pGEM-T
- pENTR221

Search Santa Cruz Biotechnology (SCBT) for PSMB6 siRNA/shRNA

Clone Products

OriGene clones in human,mouse,rat for PSMB6
- MC200922
- RN205587
- SC101180
- SC200557
- SC322188
- SC334506
OriGene ORF clones in human,mouse,rat for PSMB6
- MG202087
- MR202087
- MR202087L3
- MR202087L3V
- MR202087L4
- MR202087L4V
- RC201605
- RC201605L1
- RC201605L1V
- RC201605L2
- RC201605L2V
- RC201605L3
- RC201605L3V
- RC201605L4
- RC201605L4V
- RC236612
- RG201605
- RR205587
- RR205587L3
- RR205587L3V
- RR205587L4
- RR205587L4V
Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling

Sino Biological Human cDNA Clone for PSMB6

Addgene plasmids for PSMB6

Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PSMB6

genomics-online: cdna clones - Search for available PSMB6 CDNA products
Overview of 149 available PSMB6 gene related products
Recommended
- pCMV6-Entry
- pCMV-SPORT6
- pCMV-SPORT6ccdB
- pExpress-1
- pDNR-LIB
- pUC19
- pGEM-T
- pENTR221
orf clones - Search for available PSMB6 ORF products
Overview of 149 available PSMB6 gene related products
Recommended
- pCMV6-Entry
- pCMV-SPORT6
- pCMV-SPORT6ccdB
- pExpress-1
- pDNR-LIB
- pUC19
- pGEM-T
- pENTR221

Applied Biological Materials (abm): Clones for PSMB6 - Select products 50% OFF >
* PSMB6 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
* PSMB6 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for PSMB6 Gene

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3	^	4a	·	4b	^	5	^	6a	·	6b	·	6c	·	6d
SP1:											-										-
SP2:											-				-						-
SP3:											-
SP4:

Relevant External Links for PSMB6 Gene

GeneLoc Exon Structure for: PSMB6
ECgene alternative splicing isoforms for: PSMB6

Expression for PSMB6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSMB6 Gene

mRNA expression in normal human tissues for PSMB6 Gene

Protein differential expression in normal tissues from HIPED for PSMB6 Gene

This gene is overexpressed in Liver, secretome (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMB6 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MaxQB, and MOPED for PSMB6 Gene

Integrated proteomics: cell line protein expression from ProteomicsDB, MOPED and MaxQB for PSMB6 Gene

Protein tissue co-expression partners for PSMB6 Gene

PSMB5

NURSA nuclear receptor signaling pathways regulating expression of PSMB6 Gene:

PSMB6

SOURCE GeneReport for Unigene cluster for PSMB6 Gene:

Hs.77060

Evidence on tissue expression from TISSUES for PSMB6 Gene

Nervous system(4.8)
Liver(3.4)
Lung(3.3)
Heart(2.3)
Muscle(2.2)
Kidney(2.1)
Spleen(2.1)

Primer Products

OriGene qPCR primer pairs for PSMB6
- HP206423
- MP211895
OriGene qPCR primer pairs and template standards for PSMB6
- HK209189
- MK200608

genomics-online: primer clones - Search for available PSMB6 Primer products
Overview of 149 available PSMB6 gene related products
Recommended
- pCMV6-Entry
- pCMV-SPORT6
- pCMV-SPORT6ccdB
- pExpress-1
- pDNR-LIB
- pUC19
- pGEM-T
- pENTR221

Gene Expression Assay Products

Applied Biosystems by Thermo Fisher Scientific TaqMan® Assays for PSMB6

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMB6 Gene

Orthologs for PSMB6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMB6 Gene

Organism	Taxonomy	Gene	Similarity	Type	Details
chimpanzee (Pan troglodytes)	Mammalia	PSMB6 ³³ ³²	99.3 (n)	OneToOne	17:4813666-4815987 454453 XM_511290.4 XP_511290.2
dog (Canis familiaris)	Mammalia	PSMB6 ³³ ³²	89.92 (n)	OneToOne	5:31776235-31778833 607466 XM_844148.3 XP_849241.1
cow (Bos Taurus)	Mammalia	PSMB6 ³³ ³²	89.78 (n)	OneToOne	19:27198593-27200805 510069 NM_001034369.2 NP_001029541.1
mouse (Mus musculus)	Mammalia	Psmb6 ¹⁷ ³³ ³²	89.64 (n)		70525367 11:70525367-70527858 19175 NM_008946.4 NP_032972.3
oppossum (Monodelphis domestica)	Mammalia	-- ³³	82 (a)	OneToMany	2:256087163-256092426
oppossum (Monodelphis domestica)	Mammalia	-- ³³	57 (a)	OneToMany	6:113178694-113179403
lizard (Anolis carolinensis)	Reptilia	PSMB6 ³³	76 (a)	OneToOne	5:60525537-60542660
tropical clawed frog (Silurana tropicalis)	Amphibia	psmb6 ³²	75.52 (n)		394756 NM_203820.1 NP_989151.1
tropical clawed frog (Silurana tropicalis)	Amphibia	MGC75674 ³²			BC061603.1
zebrafish (Danio rerio)	Actinopterygii	psmb6 ³³ ³² ³²	75.04 (n)	OneToOne	23:44652957-44662183 30388 NM_131152.1 NP_571227.1
rainbow trout (Oncorhynchus mykiss)	Actinopterygii	Omy.8481 ³²			CA382803.1
fruit fly (Drosophila melanogaster)	Insecta	l(2)05070 ³⁴	57 (a)
fruit fly (Drosophila melanogaster)	Insecta	Prosbeta1 ³³	54 (a)	OneToMany	2R:11901309-11902285
worm (Caenorhabditis elegans)	Secernentea	pbs-1 ³³	40 (a)	OneToMany	IV:1708804-1709745
A. gosspyii yeast (Ashbya gossypii)	Saccharomycetes	AGOS_AAL172C ³²	60.1 (n)		4618797 NM_207723.1 NP_982370.1
K. lactis yeast (Kluyveromyces lactis)	Saccharomycetes	KLLA0F12936g ³²	57.19 (n)		2895912 XM_455662.1 XP_455662.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	PRE3 ³⁵ ³³ ³²	54.06 (n)		X:435163-435926 853456 NP_012533.1
thale cress (Arabidopsis thaliana)	eudicotyledons	PBA1 ³²	54.15 (n)		829257 NM_001036682.1 NP_001031759.1
rice (Oryza sativa)	Liliopsida	Os02g0770000 ³²	55.39 (n)		4330861 NM_001054782.1 NP_001048247.1
sea squirt (Ciona savignyi)	Ascidiacea	CSA.5051 ³³	63 (a)	OneToMany	reftig_27:1127037-1130472
sea squirt (Ciona savignyi)	Ascidiacea	Cin.5142 ³²			BW189170.1
bread mold (Neurospora crassa)	Ascomycetes	NCU09290 ³²	58.38 (n)		3874289 XM_953049.2 XP_958142.2
fission yeast (Schizosaccharomyces pombe)	Schizosaccharomycetes	pre3 ³²	56.6 (n)		2540878 NP_596295.1
sea squirt (Ciona intestinalis)	Ascidiacea	Cin.5142 ³²			BW189170.1

Species where no ortholog for PSMB6 was found in the sources mined by GeneCards:

Actinobacteria (Mycobacterium tuberculosis)
African clawed frog (Xenopus laevis)
African malaria mosquito (Anopheles gambiae)
Alicante grape (Vitis vinifera)
alpha proteobacteria (Wolbachia pipientis)
amoeba (Dictyostelium discoideum)
Archea (Pyrococcus horikoshii)
barley (Hordeum vulgare)
beta proteobacteria (Neisseria meningitidis)
chicken (Gallus gallus)
Chromalveolata (Phytophthora infestans)
common water flea (Daphnia pulex)
corn (Zea mays)
E. coli (Escherichia coli)
filamentous fungi (Aspergillus nidulans)
Firmicute bacteria (Streptococcus pneumoniae)
green algae (Chlamydomonas reinhardtii)
honey bee (Apis mellifera)
loblloly pine (Pinus taeda)
malaria parasite (Plasmodium falciparum)
medicago trunc (Medicago Truncatula)
moss (Physcomitrella patens)
orangutan (Pongo pygmaeus)
pig (Sus scrofa)
platypus (Ornithorhynchus anatinus)
rat (Rattus norvegicus)
rice blast fungus (Magnaporthe grisea)
schistosome parasite (Schistosoma mansoni)
sea anemone (Nematostella vectensis)
sea urchin (Strongylocentrotus purpuratus)
sorghum (Sorghum bicolor)
soybean (Glycine max)
stem rust fungus (Puccinia graminis)
sugarcane (Saccharum officinarum)
tomato (Lycopersicon esculentum)
toxoplasmosis (Toxoplasma gondii)
Trichoplax (Trichoplax adhaerens)
wheat (Triticum aestivum)

Evolution for PSMB6 Gene

ENSEMBL:: Gene Tree for PSMB6 (if available)
TreeFam:: Gene Tree for PSMB6 (if available)
Aminode:: Evolutionary constrained regions (ECRs) for PSMB6: view image

Paralogs for PSMB6 Gene

PSMB9 ⁵
PSMB7 ⁵
PSMB5 ⁵
PSMB11 ⁵
PSMB10 ⁵
PSMB8 ⁵
PSMB4 ⁵
PSMB1 ⁵
PSMB3 ⁵
ENSG00000256646 ⁵
PSMA2 ⁵
PSMA5 ⁵
PSMA6 ⁵
PSMB2 ⁵
PSMA7 ⁵
PSMA4 ⁵
PSMA8 ⁵
PSMA1 ⁵
PSMA3 ⁵
ENSG00000256206 ⁵

(6) SIMAP similar genes for PSMB6 Gene using alignment to 3 proteins:

PSB6_HUMAN
I3L3X7_HUMAN
Q6IAT9_HUMAN

Variants for PSMB6 Gene

Sequence variations from dbSNP and Humsavar for PSMB6 Gene

SNP ID	Clin	Chr 17 pos	Variation	Type
rs1001687886	--	4,797,033(+)	G/A	intron_variant
rs1001789495	--	4,797,517(+)	G/A	coding_sequence_variant, missense_variant
rs1002160968	--	4,798,771(+)	C/T	downstream_transcript_variant
rs1002355072	--	4,794,549(+)	T/C	upstream_transcript_variant
rs1002742017	--	4,796,051(+)	G/A/T	upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PSMB6 Gene

Variant ID	Type	Subtype	PubMed ID
nsv574273	CNV	gain	21841781
nsv833346	CNV	loss	17160897
nsv833347	CNV	loss	17160897

Variation tolerance for PSMB6 Gene

Residual Variation Intolerance Score: 58.4% of all genes are more intolerant (likely to be disease-causing)

Gene Damage Index Score: 3.68; 57.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PSMB6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for: PSMB6

SNP Genotyping and Copy Number Assay Products

Applied Biosystems by Thermo Fisher Scientific TaqMan® Assays for PSMB6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMB6 Gene

Disorders for PSMB6 Gene

Additional Disease Information for PSMB6

Genetic Association Database: (GAD)
Human Genome Epidemiology Navigator: (HuGE)
: ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PSMB6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMB6 Gene

Publications for PSMB6 Gene

cDNA cloning and interferon gamma down-regulation of proteasomal subunits X and Y. (PMID: 8066462) Akiyama K … Ichihara A (Science (New York, N.Y.) 1994) ² ³ ⁴ ⁵⁶
The primary structures of four subunits of the human, high-molecular-weight proteinase, macropain (proteasome), are distinct but homologous. (PMID: 1888762) DeMartino GN … Slaughter CA (Biochimica et biophysica acta 1991) ² ³ ⁴ ⁵⁶
An atomic structure of the human 26S proteasome. (PMID: 27428775) Huang X … Shi Y (Nature structural & molecular biology 2016) ³ ⁴ ⁵⁶
Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X … Huang L (Biochemistry 2007) ³ ⁴ ⁵⁶
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) ³ ⁴ ⁵⁶