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Aliases for PSMB5 Gene

Aliases for PSMB5 Gene

  • Proteasome Subunit Beta 5 2 3 5
  • Proteasome (Prosome, Macropain) Subunit, Beta Type, 5 2 3
  • Multicatalytic Endopeptidase Complex Epsilon Chain 3 4
  • Proteasome Epsilon Chain 3 4
  • Macropain Epsilon Chain 3 4
  • Proteasome Subunit MB1 3 4
  • Proteasome Subunit X 3 4
  • Proteasome Chain 6 3 4
  • LMPX 3 4
  • MB1 3 4
  • X 3 4
  • PSX Large Multifunctional Protease X 3
  • Proteasome Subunit, Beta Type, 5 3
  • Testicular Tissue Protein Li 153 3
  • Proteasome Catalytic Subunit 3 3
  • Proteasome Subunit Beta Type-5 3
  • Proteasome Beta 5 Subunit 3
  • EC 3.4.25.1 4

External Ids for PSMB5 Gene

Previous GeneCards Identifiers for PSMB5 Gene

  • GC14M020867
  • GC14M017282
  • GC14M021475
  • GC14M021485
  • GC14M022564
  • GC14M023495
  • GC14M003612
  • GC14M023485

Summaries for PSMB5 Gene

Entrez Gene Summary for PSMB5 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. This catalytic subunit is not present in the immunoproteasome and is replaced by catalytic subunit 3i (proteasome beta 8 subunit). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]

GeneCards Summary for PSMB5 Gene

PSMB5 (Proteasome Subunit Beta 5) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and RET signaling. Gene Ontology (GO) annotations related to this gene include peptidase activity and threonine-type endopeptidase activity. An important paralog of this gene is PSMB8.

UniProtKB/Swiss-Prot for PSMB5 Gene

  • Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity.

Gene Wiki entry for PSMB5 Gene

Additional gene information for PSMB5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMB5 Gene

Genomics for PSMB5 Gene

GeneHancer (GH) Regulatory Elements for PSMB5 Gene

Promoters and enhancers for PSMB5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J023033 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 659.4 +0.5 522 2.8 PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 IRF4 YY1 PSMB5 ACIN1 RBM23 HAUS4 NGDN PRMT5 LOC102724814 PABPN1 HOMEZ C14orf93
GH14J022976 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 15.1 +55.3 55324 7.6 MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 E2F8 ZNF143 AJUBA ACIN1 NGDN HAUS4 PRMT5 C14orf93 RBM23 LOC102724814 PABPN1 MMP14
GH14J023067 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 12.2 -35.2 -35232 5.9 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ACIN1 C14orf93 RBM23 LOC102724814 NGDN HAUS4 PRMT5 PSMB11 PSMB5 C14orf119
GH14J022955 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.1 +78.6 78625 2.6 HDGF PKNOX1 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 HAUS4 MIR4707 ACIN1 C14orf93 C14orf119 RBM23 PRMT5 LOC102724814 AJUBA PSMB5
GH14J022994 Enhancer 1.2 Ensembl ENCODE dbSUPER 12 +40.4 40363 1.1 ELF3 ARID4B ZNF48 RAD21 EGR1 ZNF143 EGR2 HMG20B ZNF654 REST PRMT5 CDH24 PSMB5 PSMB11 ACIN1 GC14P024330 ENSG00000258457 ENSG00000280129 C14orf93
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSMB5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PSMB5 gene promoter:
  • Nkx2-5
  • ATF
  • Pax-5
  • Zic3
  • RFX1

Genomic Locations for PSMB5 Gene

Genomic Locations for PSMB5 Gene
chr14:23,016,543-23,035,230
(GRCh38/hg38)
Size:
18,688 bases
Orientation:
Minus strand
chr14:23,485,752-23,504,439
(GRCh37/hg19)
Size:
18,688 bases
Orientation:
Minus strand

Genomic View for PSMB5 Gene

Genes around PSMB5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMB5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMB5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMB5 Gene

Proteins for PSMB5 Gene

  • Protein details for PSMB5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28074-PSB5_HUMAN
    Recommended name:
    Proteasome subunit beta type-5
    Protein Accession:
    P28074
    Secondary Accessions:
    • B2R4N9
    • B4DUM9
    • D3DS43
    • E9PAV2
    • Q16242
    • Q6PEW2
    • Q7Z3B5
    • Q86T01
    • Q9TNN9

    Protein attributes for PSMB5 Gene

    Size:
    263 amino acids
    Molecular mass:
    28480 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. Directly interacts with POMP (PubMed:15944226). Interacts with HIV-1 TAT protein (PubMed:14550573). Interacts with ABCB1 and TAP1 (PubMed:15488952).
    SequenceCaution:
    • Sequence=AAP35423.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA06097.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD97956.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PSMB5 Gene

    Alternative splice isoforms for PSMB5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMB5 Gene

Post-translational modifications for PSMB5 Gene

  • Ubiquitination at posLast=9292 and posLast=9191
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PSMB5 Gene

Domains & Families for PSMB5 Gene

Gene Families for PSMB5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PSMB5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P28074

UniProtKB/Swiss-Prot:

PSB5_HUMAN :
  • Belongs to the peptidase T1B family.
Family:
  • Belongs to the peptidase T1B family.
genes like me logo Genes that share domains with PSMB5: view

Function for PSMB5 Gene

Molecular function for PSMB5 Gene

UniProtKB/Swiss-Prot Function:
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity.
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of peptide bonds with very broad specificity.
UniProtKB/Swiss-Prot Induction:
Down-regulated by IFNG/IFN-gamma (at protein level). Induced in breast cancer tissue. Up-regulated by sulforaphane in breast cancer cells.
GENATLAS Biochemistry:
multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,beta,subunit MB-1/X,22.9kDa

Enzyme Numbers (IUBMB) for PSMB5 Gene

Phenotypes From GWAS Catalog for PSMB5 Gene

Gene Ontology (GO) - Molecular Function for PSMB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IBA,IEA --
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 14733938
GO:0008233 peptidase activity IDA 17540904
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PSMB5: view
genes like me logo Genes that share phenotypes with PSMB5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PSMB5

CRISPR Products

miRNA for PSMB5 Gene

miRTarBase miRNAs that target PSMB5

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMB5

Clone Products

  • Addgene plasmids for PSMB5

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMB5 Gene

Localization for PSMB5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMB5 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMB5 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
nucleus 5
cytosol 5
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PSMB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA,TAS 17323924
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA,IEA --
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with PSMB5: view

Pathways & Interactions for PSMB5 Gene

SuperPathways for PSMB5 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 Chks in Checkpoint Regulation
4 HIV Life Cycle
.45
5 Class I MHC mediated antigen processing and presentation
genes like me logo Genes that share pathways with PSMB5: view

Gene Ontology (GO) - Biological Process for PSMB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006508 proteolysis IDA 17540904
genes like me logo Genes that share ontologies with PSMB5: view

No data available for SIGNOR curated interactions for PSMB5 Gene

Drugs & Compounds for PSMB5 Gene

(21) Drugs for PSMB5 Gene - From: DrugBank, DGIdb, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other, Target Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 826
carfilzomib Approved, Investigational Pharma other, Inhibitor, Target Other, 20S Proteasome Inhibitor 0
Kyprolis Approved July 2012 Pharma 0
Velcade Approved May 2003 Pharma 0
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Experimental Pharma Target 0
genes like me logo Genes that share compounds with PSMB5: view

Transcripts for PSMB5 Gene

Unigene Clusters for PSMB5 Gene

Proteasome (prosome, macropain) subunit, beta type, 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMB5

Clone Products

  • Addgene plasmids for PSMB5

Alternative Splicing Database (ASD) splice patterns (SP) for PSMB5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for PSMB5 Gene

GeneLoc Exon Structure for
PSMB5
ECgene alternative splicing isoforms for
PSMB5

Expression for PSMB5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSMB5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PSMB5 Gene

This gene is overexpressed in Liver, secretome (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMB5 Gene



Protein tissue co-expression partners for PSMB5 Gene

NURSA nuclear receptor signaling pathways regulating expression of PSMB5 Gene:

PSMB5

SOURCE GeneReport for Unigene cluster for PSMB5 Gene:

Hs.422990

Evidence on tissue expression from TISSUES for PSMB5 Gene

  • Nervous system(4.9)
  • Liver(4.8)
  • Kidney(4.6)
  • Skin(4.4)
  • Muscle(4.3)
  • Lung(3.3)
  • Pancreas(2.6)
  • Eye(2.4)
genes like me logo Genes that share expression patterns with PSMB5: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMB5 Gene

Orthologs for PSMB5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMB5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PSMB5 34 33
  • 92.24 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PSMB5 34
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSMB5 34 33
  • 91.76 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSMB5 34
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Psmb5 16 34 33
  • 88.67 (n)
rat
(Rattus norvegicus)
Mammalia Psmb5 33
  • 88.47 (n)
chimpanzee
(Pan troglodytes)
Mammalia PSMB5 34
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSMB5 34
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psmb5 33
  • 75.16 (n)
zebrafish
(Danio rerio)
Actinopterygii psmb5 34 33 33
  • 67.7 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11284 33
fruit fly
(Drosophila melanogaster)
Insecta Prosbeta5 34 33
  • 63.86 (n)
ManyToMany
Pros&bgr;5 35
  • 63 (a)
CG9868 35
  • 57 (a)
CG31742 34
  • 40 (a)
ManyToMany
Prosbeta5R 34
  • 40 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010718 33
  • 60.55 (n)
worm
(Caenorhabditis elegans)
Secernentea pbs-5 34 33
  • 52.4 (n)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRE2 36 34
  • 51 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G26340 33
  • 59.32 (n)
rice
(Oryza sativa)
Liliopsida Os06g0153800 33
  • 63.24 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8465 34
  • 62 (a)
OneToMany
Cin.1918 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1918 33
Species where no ortholog for PSMB5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSMB5 Gene

ENSEMBL:
Gene Tree for PSMB5 (if available)
TreeFam: