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Aliases for PSMB4 Gene

Aliases for PSMB4 Gene

  • Proteasome Subunit Beta 4 2 3 5
  • Proteasome (Prosome, Macropain) Subunit, Beta Type, 4 2 3
  • Multicatalytic Endopeptidase Complex Beta Chain 3 4
  • 26 KDa Prosomal Protein 3 4
  • Proteasome Beta Chain 3 4
  • Macropain Beta Chain 3 4
  • Proteasome Chain 3 3 4
  • HsBPROS26 3 4
  • PROS-26 3 4
  • PROS26 3 4
  • HsN3 3 4
  • Testis Tissue Sperm-Binding Protein Li 79P 3
  • Proteasome Subunit, Beta Type, 4 3
  • Proteasome Subunit Beta Type-4 3
  • Proteasome Subunit HsN3 3
  • EC 3.4.25.1 4
  • HN3 3

External Ids for PSMB4 Gene

Previous GeneCards Identifiers for PSMB4 Gene

  • GC01P149213
  • GC01P147119
  • GC01P148147
  • GC01P148588
  • GC01P148185
  • GC01P149610
  • GC01P122750

Summaries for PSMB4 Gene

Entrez Gene Summary for PSMB4 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. [provided by RefSeq, Jul 2008]

GeneCards Summary for PSMB4 Gene

PSMB4 (Proteasome Subunit Beta 4) is a Protein Coding gene. Diseases associated with PSMB4 include Fallopian Tube Carcinoma. Among its related pathways are Cell Cycle, Mitotic and RET signaling. Gene Ontology (GO) annotations related to this gene include threonine-type endopeptidase activity and lipopolysaccharide binding.

UniProtKB/Swiss-Prot for PSMB4 Gene

  • Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1.

Gene Wiki entry for PSMB4 Gene

Additional gene information for PSMB4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMB4 Gene

Genomics for PSMB4 Gene

GeneHancer (GH) Regulatory Elements for PSMB4 Gene

Promoters and enhancers for PSMB4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J151398 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.6 571 3 HDGF FOXA2 PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 PSMB4 SELENBP1 SETDB1 GOLPH3L ZNF687 PI4KB UBE2D3P3 CTSK PIR34591
GH01J150969 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 18.2 -424.6 -424577 10.6 CLOCK MLX ZFP64 DMAP1 YY1 E2F8 ZNF143 SP3 SSRP1 GLIS1 CERS2 ENSG00000231073 PRPF3 SETDB1 ZNF687 HORMAD1 PIP5K1A ARNT GOLPH3L PI4KB
GH01J151054 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 18.2 -340.5 -340530 9.9 CLOCK YBX1 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 MLLT11 CDC42SE1 SETDB1 PRPF3 ARNT PIP5K1A PI4KB ZNF687 GABPB2 UBE2D3P3
GH01J151164 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 18.2 -233.5 -233485 3.1 CLOCK DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC MEF2D ZNF610 LYSMD1 SCNM1 PRPF3 SETDB1 PI4KB ARNT UBE2D3P3 ZNF687 PIP5K1A CTSK
GH01J152045 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10 +649.1 649070 6.6 HDGF PKNOX1 CLOCK ARNT ARID4B NEUROD1 SIN3A YBX1 FEZF1 DMAP1 S100A11 LOC101927949 PI4KB ZNF687 PIP5K1A MRPL9 ENSG00000229021 FLG-AS1 GABPB2 RPS10P6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSMB4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PSMB4 gene promoter:
  • HNF-4alpha1
  • USF1
  • USF-1
  • COMP1
  • NF-1
  • NF-1/L
  • HNF-1
  • HNF-1A
  • ISGF-3
  • Cart-1

Genomic Locations for PSMB4 Gene

Genomic Locations for PSMB4 Gene
chr1:151,399,534-151,401,944
(GRCh38/hg38)
Size:
2,411 bases
Orientation:
Plus strand
chr1:151,372,010-151,374,420
(GRCh37/hg19)
Size:
2,411 bases
Orientation:
Plus strand

Genomic View for PSMB4 Gene

Genes around PSMB4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMB4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMB4 Gene

Proteins for PSMB4 Gene

  • Protein details for PSMB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28070-PSB4_HUMAN
    Recommended name:
    Proteasome subunit beta type-4
    Protein Accession:
    P28070
    Secondary Accessions:
    • B2R9L3
    • P31148
    • Q5SZS5
    • Q6IBI4
    • Q969L6

    Protein attributes for PSMB4 Gene

    Size:
    264 amino acids
    Molecular mass:
    29204 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. Interacts with HIV-1 TAT and HIV-1 NEF proteins (PubMed:14550573). Interaction with HTLV-1 TAX protein favors NFKB1 activation (PubMed:8692272). Forms a ternary complex with SMAD1 and OAZ1 before PSMB4 is incorporated into the 20S proteasome. Interacts with PRPF19 (PubMed:11571290, PubMed:12097147).

    Three dimensional structures from OCA and Proteopedia for PSMB4 Gene

neXtProt entry for PSMB4 Gene

Post-translational modifications for PSMB4 Gene

  • Ubiquitination at Lys109
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMB4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PSMB4 Gene

Domains & Families for PSMB4 Gene

Gene Families for PSMB4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PSMB4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P28070

UniProtKB/Swiss-Prot:

PSB4_HUMAN :
  • Belongs to the peptidase T1B family.
Family:
  • Belongs to the peptidase T1B family.
genes like me logo Genes that share domains with PSMB4: view

Function for PSMB4 Gene

Molecular function for PSMB4 Gene

UniProtKB/Swiss-Prot Function:
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1.
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of peptide bonds with very broad specificity.
UniProtKB/Swiss-Prot Induction:
Up-regulated in fibrolamellar carcinomas.
GENATLAS Biochemistry:
multicatalytic proteinase complex (20s),proteasome (prosome,macropain) component,beta 4 (HSBpros26),29.2kDa

Enzyme Numbers (IUBMB) for PSMB4 Gene

Phenotypes From GWAS Catalog for PSMB4 Gene

Gene Ontology (GO) - Molecular Function for PSMB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding IEA --
GO:0004175 endopeptidase activity IEA,IBA --
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008233 peptidase activity IEA --
genes like me logo Genes that share ontologies with PSMB4: view
genes like me logo Genes that share phenotypes with PSMB4: view

Animal Model Products

CRISPR Products

miRNA for PSMB4 Gene

miRTarBase miRNAs that target PSMB4

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMB4

Clone Products

  • Addgene plasmids for PSMB4

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMB4 Gene

Localization for PSMB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMB4 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMB4 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
cytoskeleton 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Cytosol (2)
  • Intermediate filaments (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PSMB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA,TAS 17323924
GO:0005634 nucleus TAS 16130169
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PSMB4: view

Pathways & Interactions for PSMB4 Gene

SuperPathways for PSMB4 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 Chks in Checkpoint Regulation
4 HIV Life Cycle
.45
5 Class I MHC mediated antigen processing and presentation
genes like me logo Genes that share pathways with PSMB4: view

Gene Ontology (GO) - Biological Process for PSMB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0002862 negative regulation of inflammatory response to antigenic stimulus IEA --
genes like me logo Genes that share ontologies with PSMB4: view

No data available for SIGNOR curated interactions for PSMB4 Gene

Drugs & Compounds for PSMB4 Gene

(3) Drugs for PSMB4 Gene - From: DrugBank and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 826
carfilzomib Approved, Investigational Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Experimental Pharma Target 0
genes like me logo Genes that share compounds with PSMB4: view

Transcripts for PSMB4 Gene

mRNA/cDNA for PSMB4 Gene

(1) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(1191) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PSMB4 Gene

Proteasome (prosome, macropain) subunit, beta type, 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMB4

Clone Products

  • Addgene plasmids for PSMB4

Alternative Splicing Database (ASD) splice patterns (SP) for PSMB4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b
SP1: - - - - - -
SP2: - - - - -
SP3: - -
SP4: -
SP5: -
SP6: - - - -
SP7: -
SP8:
SP9: -

Relevant External Links for PSMB4 Gene

GeneLoc Exon Structure for
PSMB4
ECgene alternative splicing isoforms for
PSMB4

Expression for PSMB4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSMB4 Gene

Protein differential expression in normal tissues from HIPED for PSMB4 Gene

This gene is overexpressed in Liver, secretome (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMB4 Gene



Protein tissue co-expression partners for PSMB4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PSMB4 Gene:

PSMB4

SOURCE GeneReport for Unigene cluster for PSMB4 Gene:

Hs.89545

Evidence on tissue expression from TISSUES for PSMB4 Gene

  • Skin(4.9)
  • Nervous system(4.9)
  • Liver(4.7)
  • Lung(4.3)
  • Eye(3.7)
  • Pancreas(3.3)
  • Kidney(2.6)
  • Bone(2.3)
  • Intestine(2.2)
  • Lymph node(2.2)
  • Muscle(2.2)
  • Bone marrow(2.1)
  • Heart(2.1)
  • Adrenal gland(2)
  • Blood(2)
  • Gall bladder(2)
  • Spleen(2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with PSMB4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMB4 Gene

Orthologs for PSMB4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMB4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMB4 34 33
  • 99.75 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PSMB4 34 33
  • 90.91 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSMB4 34
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSMB4 34 33
  • 89.65 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Psmb4 16 34 33
  • 87.88 (n)
rat
(Rattus norvegicus)
Mammalia Psmb4 33
  • 87.21 (n)
oppossum
(Monodelphis domestica)
Mammalia PSMB4 34
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves PSMB4 34 33
  • 72.87 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSMB4 34
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psmb4 33
  • 71.26 (n)
Str.129 33
African clawed frog
(Xenopus laevis)
Amphibia psmb4-prov 33
zebrafish
(Danio rerio)
Actinopterygii psmb4 34 33
  • 74.42 (n)
OneToOne
Dr.15385 33