The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiq... See more...

Aliases for PSMB4 Gene

Aliases for PSMB4 Gene

  • Proteasome 20S Subunit Beta 4 2 3 5
  • PROS26 2 3 4
  • Proteasome (Prosome, Macropain) Subunit, Beta Type, 4 2 3
  • Multicatalytic Endopeptidase Complex Beta Chain 3 4
  • Proteasome Subunit Beta Type-4 3 4
  • Proteasome Subunit Beta 4 2 3
  • 26 KDa Prosomal Protein 3 4
  • Proteasome Beta Chain 3 4
  • Macropain Beta Chain 3 4
  • Proteasome Chain 3 3 4
  • HsBPROS26 3 4
  • PROS-26 3 4
  • HsN3 3 4
  • HN3 2 3
  • Testis Tissue Sperm-Binding Protein Li 79P 3
  • Proteasome Subunit, Beta Type, 4 3
  • Proteasome Subunit Beta7 3
  • Proteasome Subunit HsN3 3
  • Proteasome Subunit Β7 2
  • EC 3.4.25.1 51
  • PRAAS3 3
  • PSMB4 5

External Ids for PSMB4 Gene

Previous GeneCards Identifiers for PSMB4 Gene

  • GC01P149213
  • GC01P147119
  • GC01P148147
  • GC01P148588
  • GC01P148185
  • GC01P149610
  • GC01P122750

Summaries for PSMB4 Gene

Entrez Gene Summary for PSMB4 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. [provided by RefSeq, Jul 2008]

GeneCards Summary for PSMB4 Gene

PSMB4 (Proteasome 20S Subunit Beta 4) is a Protein Coding gene. Diseases associated with PSMB4 include Proteasome-Associated Autoinflammatory Syndrome 3 and Nakajo Syndrome. Among its related pathways are Downstream signaling events of B Cell Receptor (BCR) and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include threonine-type endopeptidase activity and lipopolysaccharide binding. An important paralog of this gene is PSMB8.

UniProtKB/Swiss-Prot Summary for PSMB4 Gene

  • Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1.

Gene Wiki entry for PSMB4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSMB4 Gene

Genomics for PSMB4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PSMB4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSMB4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PSMB4

Top Transcription factor binding sites by QIAGEN in the PSMB4 gene promoter:
  • Cart-1
  • COMP1
  • HNF-1
  • HNF-1A
  • HNF-4alpha1
  • ISGF-3
  • NF-1
  • NF-1/L
  • USF-1
  • USF1

Genomic Locations for PSMB4 Gene

Latest Assembly
chr1:151,399,560-151,401,937
(GRCh38/hg38)
Size:
2,378 bases
Orientation:
Plus strand

Previous Assembly
chr1:151,372,049-151,374,413
(GRCh37/hg19 by Entrez Gene)
Size:
2,365 bases
Orientation:
Plus strand

chr1:151,372,010-151,374,420
(GRCh37/hg19 by Ensembl)
Size:
2,411 bases
Orientation:
Plus strand

Genomic View for PSMB4 Gene

Genes around PSMB4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMB4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMB4 Gene

Proteins for PSMB4 Gene

  • Protein details for PSMB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28070-PSB4_HUMAN
    Recommended name:
    Proteasome subunit beta type-4
    Protein Accession:
    P28070
    Secondary Accessions:
    • B2R9L3
    • P31148
    • Q5SZS5
    • Q6IBI4
    • Q969L6

    Protein attributes for PSMB4 Gene

    Size:
    264 amino acids
    Molecular mass:
    29204 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. Forms a ternary complex with SMAD1 and OAZ1 before PSMB4 is incorporated into the 20S proteasome. Interacts with PRPF19 (PubMed:11571290, PubMed:12097147).
    • (Microbial infection) Interacts with HTLV-1 Tax protein.
    • (Microbial infection) Interacts with HIV-1 Nef and Tat proteins.

    Three dimensional structures from OCA and Proteopedia for PSMB4 Gene

neXtProt entry for PSMB4 Gene

Selected DME Specific Peptides for PSMB4 Gene

P28070:
  • LGASGDYAD
  • QMVIDEEL
  • RRSKMNPLWN
  • LGSYGSL
  • AIHSWLTRAMY
  • GVVIAAD
  • VLYYRDARSYNRF
  • GESFLGYVD
  • PITRTQNPMVTGTSVLG

Post-translational modifications for PSMB4 Gene

  • Ubiquitination at Lys109 and Lys201
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMB4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PSMB4 Gene

Gene Families for PSMB4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PSMB4 Gene

InterPro:
Blocks:
  • Proteasome B-type subunit
ProtoNet:

Suggested Antigen Peptide Sequences for PSMB4 Gene

GenScript: Design optimal peptide antigens:
  • Proteasome chain 3 (PSB4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P28070

UniProtKB/Swiss-Prot:

PSB4_HUMAN :
  • Belongs to the peptidase T1B family.
Family:
  • Belongs to the peptidase T1B family.
genes like me logo Genes that share domains with PSMB4: view

Function for PSMB4 Gene

Molecular function for PSMB4 Gene

UniProtKB/Swiss-Prot Function:
Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1.
UniProtKB/Swiss-Prot Induction:
Up-regulated in fibrolamellar carcinomas.
GENATLAS Biochemistry:
multicatalytic proteinase complex (20s),proteasome (prosome,macropain) component,beta 4 (HSBpros26),29.2kDa

Enzyme Numbers (IUBMB) for PSMB4 Gene

Phenotypes From GWAS Catalog for PSMB4 Gene

Gene Ontology (GO) - Molecular Function for PSMB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding IEA --
GO:0004175 endopeptidase activity IBA 21873635
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 15231748
GO:0008233 peptidase activity IEA --
genes like me logo Genes that share ontologies with PSMB4: view
genes like me logo Genes that share phenotypes with PSMB4: view

Human Phenotype Ontology for PSMB4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

miRNA for PSMB4 Gene

miRTarBase miRNAs that target PSMB4

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMB4

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for PSMB4 Gene

Localization for PSMB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMB4 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMB4 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
extracellular 4
plasma membrane 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Mitochondria (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PSMB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex TAS,IDA 17323924
GO:0005634 nucleus IBA,TAS 16130169
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA 21873635
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with PSMB4: view

Pathways & Interactions for PSMB4 Gene

PathCards logo

SuperPathways for PSMB4 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 Chks in Checkpoint Regulation
.59
.59
.55
.43
.32
.31
4 HIV Life Cycle
.45
5 Pathways of neurodegeneration - multiple diseases
genes like me logo Genes that share pathways with PSMB4: view

Pathways by source for PSMB4 Gene

4 GeneGo (Thomson Reuters) pathways for PSMB4 Gene
  • Immune response Antigen presentation by MHC class I
  • Regulation of degradation of deltaF508 CFTR in CF
  • Regulation of degradation of wt-CFTR
  • Transcription Ligand-Dependent Transcription of Retinoid-Target genes
17 Qiagen pathways for PSMB4 Gene
  • CDK5 Pathway
  • Chks in Checkpoint Regulation
  • DNA Repair Mechanisms
  • Estrogen-mediated S-Phase Entry
  • G2-M Phase Transition

Gene Ontology (GO) - Biological Process for PSMB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0002862 negative regulation of inflammatory response to antigenic stimulus IEA --
genes like me logo Genes that share ontologies with PSMB4: view

No data available for SIGNOR curated interactions for PSMB4 Gene

Drugs & Compounds for PSMB4 Gene

(3) Drugs for PSMB4 Gene - From: DrugBank and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 926
carfilzomib Approved, Investigational Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Experimental Pharma Target 0
genes like me logo Genes that share compounds with PSMB4: view

Transcripts for PSMB4 Gene

mRNA/cDNA for PSMB4 Gene

1 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR products for research