The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiq... See more...

Aliases for PSMB3 Gene

Aliases for PSMB3 Gene

  • Proteasome 20S Subunit Beta 3 2 3
  • Proteasome Subunit Beta 3 2 3 5
  • Proteasome (Prosome, Macropain) Subunit, Beta Type, 3 2 3
  • Proteasome Subunit Beta Type-3 3 4
  • Proteasome Component C10-II 3 4
  • Proteasome Theta Chain 3 4
  • Proteasome Chain 13 3 4
  • EC 3.4.25.1 4 52
  • Epididymis Secretory Sperm Binding Protein 3
  • HC10-II 3

External Ids for PSMB3 Gene

Previous GeneCards Identifiers for PSMB3 Gene

  • GC17P036394
  • GC17P038902
  • GC17P036819
  • GC17P037284
  • GC17P037285
  • GC17P034162
  • GC17P036909
  • GC17P032705

Summaries for PSMB3 Gene

Entrez Gene Summary for PSMB3 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. The 26 S proteasome may be involved in trinucleotide repeat expansion, a phenomenon which is associated with many hereditary neurological diseases. Pseudogenes have been identified on chromosomes 2 and 12. Alternative splicing results in multiple transcript variants [provided by RefSeq, Sep 2013]

GeneCards Summary for PSMB3 Gene

PSMB3 (Proteasome 20S Subunit Beta 3) is a Protein Coding gene. Diseases associated with PSMB3 include Nodular Episcleritis and Cystic Fibrosis. Among its related pathways are Regulation of degradation of deltaF508 CFTR in CF and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include threonine-type endopeptidase activity. An important paralog of this gene is PSMA6.

UniProtKB/Swiss-Prot Summary for PSMB3 Gene

  • Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).

Gene Wiki entry for PSMB3 Gene

Additional gene information for PSMB3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSMB3 Gene

Genomics for PSMB3 Gene

GeneHancer (GH) Regulatory Elements for PSMB3 Gene

Promoters and enhancers for PSMB3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSMB3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PSMB3

Top Transcription factor binding sites by QIAGEN in the PSMB3 gene promoter:
  • GATA-3
  • HOXA9
  • HOXA9B
  • LCR-F1
  • Meis-1
  • Meis-1b
  • MyoD
  • p300
  • Pax-5
  • YY1

Genomic Locations for PSMB3 Gene

Genomic Locations for PSMB3 Gene
chr17:38,752,713-38,764,231
(GRCh38/hg38)
Size:
11,519 bases
Orientation:
Plus strand
chr17:36,908,989-36,920,484
(GRCh37/hg19)
Size:
11,496 bases
Orientation:
Plus strand

Genomic View for PSMB3 Gene

Genes around PSMB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMB3 Gene

Proteins for PSMB3 Gene

  • Protein details for PSMB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49720-PSB3_HUMAN
    Recommended name:
    Proteasome subunit beta type-3
    Protein Accession:
    P49720
    Secondary Accessions:
    • P31147
    • Q0P6J7
    • Q96E27

    Protein attributes for PSMB3 Gene

    Size:
    205 amino acids
    Molecular mass:
    22949 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.
    • (Microbial infection) Interacts with HIV-1 TAT protein.

    Three dimensional structures from OCA and Proteopedia for PSMB3 Gene

neXtProt entry for PSMB3 Gene

Selected DME Specific Peptides for PSMB3 Gene

P49720:
  • EPVIAGLDPKTF
  • GLATDVQT
  • RFGIQAQ
  • LYEKRFGP
  • PFICSLDLIGCPMVT
  • GKNCVAIA
  • QRLKFRLNLYELKEGRQIKP
  • LFETISQ
  • CVAIAADRRFG

Post-translational modifications for PSMB3 Gene

  • Ubiquitination at Lys15, Lys17, and Lys77
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMB3 Gene

Domains & Families for PSMB3 Gene

Gene Families for PSMB3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PSMB3 Gene

Blocks:
  • Proteasome B-type subunit
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PSMB3 Gene

GenScript: Design optimal peptide antigens:
  • Proteasome theta chain (PSB3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P49720

UniProtKB/Swiss-Prot:

PSB3_HUMAN :
  • Belongs to the peptidase T1B family.
Family:
  • Belongs to the peptidase T1B family.
genes like me logo Genes that share domains with PSMB3: view

Function for PSMB3 Gene

Molecular function for PSMB3 Gene

UniProtKB/Swiss-Prot Function:
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Cleavage of peptide bonds with very broad specificity.; EC=3.4.25.1; Evidence=. ;.
UniProtKB/Swiss-Prot Induction:
Up-regulated in asthenozoospermic sperm.
GENATLAS Biochemistry:
multicatalytic proteinase complex (20s),proteasome component beta 3 (HSC10-I1),22.9kDa

Enzyme Numbers (IUBMB) for PSMB3 Gene

Phenotypes From GWAS Catalog for PSMB3 Gene

Gene Ontology (GO) - Molecular Function for PSMB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IBA,IEA 21873635
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 14733938
GO:0008233 peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PSMB3: view
genes like me logo Genes that share phenotypes with PSMB3: view

Animal Model Products

CRISPR Products

miRNA for PSMB3 Gene

miRTarBase miRNAs that target PSMB3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMB3

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMB3 Gene

Localization for PSMB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMB3 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMB3 gene
Compartment Confidence
cytosol 5
nucleus 4
mitochondrion 3
cytoskeleton 2
golgi apparatus 2
plasma membrane 1
extracellular 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for PSMB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex TAS,IDA 17323924
GO:0005634 nucleus IBA,IEA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PSMB3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PSMB3 Gene

Pathways & Interactions for PSMB3 Gene

PathCards logo

SuperPathways for PSMB3 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 Chks in Checkpoint Regulation
.59
.59
.55
.43
.32
.31
4 HIV Life Cycle
.45
5 Class I MHC mediated antigen processing and presentation
genes like me logo Genes that share pathways with PSMB3: view

Pathways by source for PSMB3 Gene

1 KEGG pathway for PSMB3 Gene
4 GeneGo (Thomson Reuters) pathways for PSMB3 Gene
  • Immune response Antigen presentation by MHC class I
  • Regulation of degradation of deltaF508 CFTR in CF
  • Regulation of degradation of wt-CFTR
  • Transcription Ligand-Dependent Transcription of Retinoid-Target genes
17 Qiagen pathways for PSMB3 Gene
  • CDK5 Pathway
  • Chks in Checkpoint Regulation
  • DNA Repair Mechanisms
  • Estrogen-mediated S-Phase Entry
  • G2-M Phase Transition

Gene Ontology (GO) - Biological Process for PSMB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PSMB3: view

No data available for SIGNOR curated interactions for PSMB3 Gene

Drugs & Compounds for PSMB3 Gene

(3) Drugs for PSMB3 Gene - From: DrugBank and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 888
carfilzomib Approved, Investigational Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Experimental Pharma Target 0
genes like me logo Genes that share compounds with PSMB3: view

Transcripts for PSMB3 Gene

mRNA/cDNA for PSMB3 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products