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Aliases for PSMB11 Gene

Aliases for PSMB11 Gene

  • Proteasome Subunit Beta 11 2 3 5
  • Proteasome (Prosome, Macropain) Subunit, Beta Type, 11 2 3
  • Proteasome Subunit Beta-5t 3 4
  • EC 3.4.25.1 4 56
  • Proteasome Subunit Beta Type-11 3
  • Proteasome Subunit Beta 5T 3
  • BETA5T 3

External Ids for PSMB11 Gene

Previous GeneCards Identifiers for PSMB11 Gene

  • GC14P022583
  • GC14P023511
  • GC14P003628
  • GC14P023393
  • GC14P023558
  • GC14P023669
  • GC14P023795
  • GC14P023883
  • GC14P023944
  • GC14P024056

Summaries for PSMB11 Gene

Entrez Gene Summary for PSMB11 Gene

  • Proteasomes generate peptides that are presented by major histocompatibility complex (MHC) I molecules to other cells of the immune system. Proteolysis is conducted by 20S proteasomes, complexes of 28 subunits arranged as a cylinder in 4 heteroheptameric rings: alpha-1 to -7, beta-1 to -7, beta-1 to -7, and alpha-1 to -7. The catalytic subunits are beta-1 (PSMB6; MIM 600307), beta-2 (PSMB7; MIM 604030), and beta-5 (PSMB5; MIM 600306). Three additional subunits, beta-1i (PSMB9; MIM 177045), beta-2i (PSMB10; MIM 176847), and beta-5i (PSMB8; MIM 177046), are induced by gamma-interferon (IFNG; MIM 147570) and are preferentially incorporated into proteasomes to make immunoproteasomes. PSMB11, or beta-5t, is a catalytic subunit expressed exclusively in cortical thymic epithelial cells (Murata et al., 2007 [PubMed 17540904]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PSMB11 Gene

PSMB11 (Proteasome Subunit Beta 11) is a Protein Coding gene. Diseases associated with PSMB11 include Thymus Cancer. Among its related pathways are RET signaling and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include threonine-type endopeptidase activity. An important paralog of this gene is PSMB8.

UniProtKB/Swiss-Prot for PSMB11 Gene

  • The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome (By similarity). Plays a pivotal role in development of CD8-positive T cells (By similarity).

Additional gene information for PSMB11 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMB11 Gene

Genomics for PSMB11 Gene

GeneHancer (GH) Regulatory Elements for PSMB11 Gene

Promoters and enhancers for PSMB11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I023042 Promoter 0.5 EPDnew 550.8 +0.0 26 0.1 PSMB11 LOC105370705
GH14I023043 Enhancer 0.2 ENCODE 550.8 +1.9 1880 0.2 PSMB11 CDH24 LOC105370705
GH14I023067 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 12.3 +28.3 28295 5.9 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ACIN1 C14orf93 NGDN LOC102724814 RBM23 HAUS4 PRMT5 PSMB11 PSMB5 C14orf119
GH14I022976 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.1 -62.3 -62261 7.6 MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 E2F8 ZNF143 AJUBA ACIN1 NGDN PRMT5 C14orf93 HAUS4 RBM23 LOC102724814 PABPN1 MMP14
GH14I022955 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.1 -85.6 -85562 2.6 HDGF PKNOX1 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 HAUS4 MIR4707 ACIN1 C14orf93 C14orf119 RBM23 LOC102724814 PRMT5 AJUBA PSMB5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PSMB11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PSMB11 gene promoter:

Genomic Locations for PSMB11 Gene

Genomic Locations for PSMB11 Gene
chr14:23,042,167-23,044,276
(GRCh38/hg38)
Size:
2,110 bases
Orientation:
Plus strand
chr14:23,511,376-23,513,269
(GRCh37/hg19)

Genomic View for PSMB11 Gene

Genes around PSMB11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMB11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMB11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMB11 Gene

Proteins for PSMB11 Gene

  • Protein details for PSMB11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A5LHX3-PSB11_HUMAN
    Recommended name:
    Proteasome subunit beta type-11
    Protein Accession:
    A5LHX3

    Protein attributes for PSMB11 Gene

    Size:
    300 amino acids
    Molecular mass:
    32530 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Incorporated instead of PSMB5 and PSMB8.

neXtProt entry for PSMB11 Gene

Selected DME Specific Peptides for PSMB11 Gene

A5LHX3:
  • GSGSPYA
  • HGTTTLAF
  • RDAYSGG

Post-translational modifications for PSMB11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PSMB11 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PSMB11 Gene

Gene Families for PSMB11 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PSMB11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A5LHX3

UniProtKB/Swiss-Prot:

PSB11_HUMAN :
  • Belongs to the peptidase T1B family.
Family:
  • Belongs to the peptidase T1B family.
genes like me logo Genes that share domains with PSMB11: view

Function for PSMB11 Gene

Molecular function for PSMB11 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of peptide bonds with very broad specificity.
UniProtKB/Swiss-Prot Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome (By similarity). Plays a pivotal role in development of CD8-positive T cells (By similarity).

Enzyme Numbers (IUBMB) for PSMB11 Gene

Phenotypes From GWAS Catalog for PSMB11 Gene

Gene Ontology (GO) - Molecular Function for PSMB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IEA --
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IDA 17540904
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PSMB11: view
genes like me logo Genes that share phenotypes with PSMB11: view

Animal Models for PSMB11 Gene

MGI Knock Outs for PSMB11:

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PSMB11 Gene

Localization for PSMB11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMB11 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMB11 gene
Compartment Confidence
cytosol 5
nucleus 4
extracellular 1

Gene Ontology (GO) - Cellular Components for PSMB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005839 proteasome core complex IEA --
genes like me logo Genes that share ontologies with PSMB11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PSMB11 Gene

Pathways & Interactions for PSMB11 Gene

SuperPathways for PSMB11 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 HIV Life Cycle
.45
4 Class I MHC mediated antigen processing and presentation
5 Cell Cycle, Mitotic
.60
genes like me logo Genes that share pathways with PSMB11: view

Gene Ontology (GO) - Biological Process for PSMB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006508 proteolysis IDA 17540904
genes like me logo Genes that share ontologies with PSMB11: view

No data available for SIGNOR curated interactions for PSMB11 Gene

Drugs & Compounds for PSMB11 Gene

(3) Drugs for PSMB11 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
AM 114 Pharma 20S proteasome inhibitor 0
CEP-18770 Pharma Proteasome inhibitor 0
MLN9708 Pharma Proteasome inhibitor, 20S Proteasome Inhibitor 0

(3) ApexBio Compounds for PSMB11 Gene

Compound Action Cas Number
AM 114 20S proteasome inhibitor 856849-35-9
CEP-18770 Proteasome inhibitor 847499-27-8
MLN9708 Proteasome inhibitor 1201902-80-8
genes like me logo Genes that share compounds with PSMB11: view

Drug Products

Transcripts for PSMB11 Gene

mRNA/cDNA for PSMB11 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PSMB11 Gene

Proteasome (prosome, macropain) subunit, beta type, 11:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMB11 Gene

No ASD Table

Relevant External Links for PSMB11 Gene

GeneLoc Exon Structure for
PSMB11
ECgene alternative splicing isoforms for
PSMB11

Expression for PSMB11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSMB11 Gene

mRNA differential expression in normal tissues according to GTEx for PSMB11 Gene

This gene is overexpressed in Testis (x26.2).

Protein differential expression in normal tissues from HIPED for PSMB11 Gene

This gene is overexpressed in Retina (57.6) and NK cells (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PSMB11 Gene



Protein tissue co-expression partners for PSMB11 Gene

NURSA nuclear receptor signaling pathways regulating expression of PSMB11 Gene:

PSMB11

SOURCE GeneReport for Unigene cluster for PSMB11 Gene:

Hs.508918
genes like me logo Genes that share expression patterns with PSMB11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMB11 Gene

Orthologs for PSMB11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PSMB11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMB11 33 34
  • 99.67 (n)
cow
(Bos Taurus)
Mammalia PSMB11 33 34
  • 84.68 (n)
dog
(Canis familiaris)
Mammalia PSMB11 33 34
  • 84.04 (n)
rat
(Rattus norvegicus)
Mammalia Psmb11 33
  • 83.28 (n)
mouse
(Mus musculus)
Mammalia Psmb11 33 16 34
  • 82.11 (n)
oppossum
(Monodelphis domestica)
Mammalia PSMB11 34
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSMB11 34
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSMB11 34
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psmb11 33
  • 52.73 (n)
zebrafish
(Danio rerio)
Actinopterygii psmb11b 33
  • 59.15 (n)
PSMB11 (1 of 2) 34
  • 55 (a)
OneToMany
SI:CH211-14A17.13 34
  • 33 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Prosbeta5 34
  • 38 (a)
ManyToMany
CG31742 34
  • 34 (a)
ManyToMany
Prosbeta5R 34
  • 34 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea pbs-5 34
  • 29 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRE2 34
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8465 34
  • 42 (a)
OneToMany
Species where no ortholog for PSMB11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSMB11 Gene

ENSEMBL:
Gene Tree for PSMB11 (if available)
TreeFam:
Gene Tree for PSMB11 (if available)

Paralogs for PSMB11 Gene

Paralogs for PSMB11 Gene

(3) SIMAP similar genes for PSMB11 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PSMB11: view

Variants for PSMB11 Gene

Sequence variations from dbSNP and Humsavar for PSMB11 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000042249 -- 23,044,185(+) T/G downstream_transcript_variant
rs1001760648 -- 23,041,779(+) G/A upstream_transcript_variant
rs1002822903 -- 23,042,740(+) G/C coding_sequence_variant, missense_variant
rs1003719609 -- 23,043,584(+) C/G 3_prime_UTR_variant
rs1003771963 -- 23,043,799(+) A/G 3_prime_UTR_variant

Variation tolerance for PSMB11 Gene

Residual Variation Intolerance Score: 86.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.57; 44.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PSMB11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMB11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PSMB11 Gene

Disorders for PSMB11 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PSMB11 Gene - From: DISEASES

Disorder Aliases PubMed IDs
thymus cancer
  • neoplasm of thymus
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PSMB11

genes like me logo Genes that share disorders with PSMB11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSMB11 Gene

Publications for PSMB11 Gene

  1. Regulation of CD8+ T cell development by thymus-specific proteasomes. (PMID: 17540904) Murata S … Tanaka K (Science (New York, N.Y.) 2007) 2 3 4 58
  2. Decreased expression of thymus-specific proteasome subunit β5t in Down syndrome patients. (PMID: 25556590) Tomaru U … Kasahara M (Histopathology 2015) 3 58
  3. Expression of thymoproteasome subunit β5t in type AB thymoma. (PMID: 24293611) Yamada Y … Matsuno Y (Journal of clinical pathology 2014) 3 58
  4. Impaired bortezomib binding to mutant β5 subunit of the proteasome is the underlying basis for bortezomib resistance in leukemia cells. (PMID: 21941364) Franke NE … Cloos J (Leukemia 2012) 3 58
  5. Expression of proteasome subunit β5t in thymic epithelial tumors. (PMID: 21836487) Yamada Y … Kasahara M (The American journal of surgical pathology 2011) 3 58

Products for PSMB11 Gene

Sources for PSMB11 Gene