Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PSMB10 Gene

Aliases for PSMB10 Gene

  • Proteasome Subunit Beta 10 2 3 5
  • Proteasome (Prosome, Macropain) Subunit, Beta Type, 10 2 3
  • Multicatalytic Endopeptidase Complex Subunit MECl-1 3 4
  • Low Molecular Mass Protein 10 3 4
  • Proteasome Subunit Beta-2i 3 4
  • Macropain Subunit MECl-1 3 4
  • Proteasome MECl-1 3 4
  • MECL1 3 4
  • LMP10 3 4
  • Proteasome Catalytic Subunit 2i 3
  • Proteasome Subunit Beta Type-10 3
  • Proteasome Subunit Beta 7i 3
  • Proteasome Subunit MECL1 3
  • EC 4
  • Beta2i 3

External Ids for PSMB10 Gene

Previous HGNC Symbols for PSMB10 Gene

  • MECL1

Previous GeneCards Identifiers for PSMB10 Gene

  • GC16M058663
  • GC16M068342
  • GC16M067699
  • GC16M067739
  • GC16M066520
  • GC16M066525
  • GC16M067968
  • GC16M053841

Summaries for PSMB10 Gene

Entrez Gene Summary for PSMB10 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Proteolytic processing is required to generate a mature subunit. Expression of this gene is induced by gamma interferon, and this gene product replaces catalytic subunit 2 (proteasome beta 7 subunit) in the immunoproteasome. [provided by RefSeq, Jul 2008]

GeneCards Summary for PSMB10 Gene

PSMB10 (Proteasome Subunit Beta 10) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and RET signaling. Gene Ontology (GO) annotations related to this gene include threonine-type endopeptidase activity. An important paralog of this gene is PSMB7.

UniProtKB/Swiss-Prot for PSMB10 Gene

  • The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides.

Gene Wiki entry for PSMB10 Gene

Additional gene information for PSMB10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMB10 Gene

Genomics for PSMB10 Gene

GeneHancer (GH) Regulatory Elements for PSMB10 Gene

Promoters and enhancers for PSMB10 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J067934 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.8 820 4 HDGF PKNOX1 SMAD1 ARNT MLX ZFP64 ARID4B SIN3A FEZF1 ZNF2 ENSG00000261884 GC16P067936 PSMB10 EDC4 E2F4 NFATC3 RANBP10 ENSG00000263276 ENSG00000260891 ENSG00000270165
GH16J067992 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 6.4 -57.8 -57792 4.1 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 POLR2B ZNF213 E2F8 DPEP2 EDC4 PRMT7 ACD CENPT CTCF ENSG00000263276 E2F4 DDX28 KIAA0895L
GH16J067479 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.4 +455.0 455035 5 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC ATP6V0D1 LOC101927837 ZDHHC1 ENKD1 NAE1 EDC4 CENPT CTCF SLC7A6OS E2F4
GH16J067527 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 5.7 +407.0 407021 4.4 ATF1 FOXA2 ARID4B SIN3A YY1 ZNF121 GLIS2 ZNF143 FOS ATF7 LOC100505942 C16orf70 ATP6V0D1 ZDHHC1 ENKD1 SLC7A6OS NAE1 PSMB10 RIPOR1 LRRC29
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSMB10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PSMB10 gene promoter:
  • p53
  • COMP1
  • GR-alpha
  • GR-beta
  • LCR-F1
  • GR
  • E47

Genomic Locations for PSMB10 Gene

Genomic Locations for PSMB10 Gene
2,586 bases
Minus strand
2,586 bases
Minus strand

Genomic View for PSMB10 Gene

Genes around PSMB10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMB10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMB10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMB10 Gene

Proteins for PSMB10 Gene

  • Protein details for PSMB10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Proteasome subunit beta type-10
    Protein Accession:
    Secondary Accessions:
    • B2R5J4
    • Q5U098

    Protein attributes for PSMB10 Gene

    273 amino acids
    Molecular mass:
    28936 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Component of the immunoproteasome, where it displaces the equivalent housekeeping subunit PSMB7. Component of the spermatoproteasome, a form of the proteasome specifically found in testis. Interacts with HIV-1 TAT protein.

    Three dimensional structures from OCA and Proteopedia for PSMB10 Gene

neXtProt entry for PSMB10 Gene

Post-translational modifications for PSMB10 Gene

  • Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile proteolytic activity.
  • Ubiquitination at posLast=236236, Lys101, posLast=7979, posLast=7272, posLast=6868, Lys37, and posLast=3131
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMB10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PSMB10 Gene

Domains & Families for PSMB10 Gene

Gene Families for PSMB10 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PSMB10 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase T1B family.
  • Belongs to the peptidase T1B family.
genes like me logo Genes that share domains with PSMB10: view

Function for PSMB10 Gene

Molecular function for PSMB10 Gene

UniProtKB/Swiss-Prot Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides.
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of peptide bonds with very broad specificity.
UniProtKB/Swiss-Prot Induction:
Up-regulated by IFNG/IFN-gamma (at protein level). Up-regulated by IRF1. Up-regulated by TNF (at protein level). Up-regulated by tetrodotoxin (TTX) in glial cells. Up-regulated in Crohns bowel disease (CD). Up-regulated by CD40L via the NFKB1 pathway in cancer cells.
GENATLAS Biochemistry:
multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,beta-type subunit MECL-1,29kDa,interferon gamma inducible

Enzyme Numbers (IUBMB) for PSMB10 Gene

Phenotypes From GWAS Catalog for PSMB10 Gene

Gene Ontology (GO) - Molecular Function for PSMB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IEA,IBA --
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 21516116
GO:0008233 peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PSMB10: view
genes like me logo Genes that share phenotypes with PSMB10: view

Animal Models for PSMB10 Gene

MGI Knock Outs for PSMB10:

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PSMB10 Gene

Localization for PSMB10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMB10 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMB10 gene
Compartment Confidence
nucleus 5
cytosol 5
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PSMB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex TAS 9551082
GO:0005634 nucleus IBA,IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PSMB10: view

Pathways & Interactions for PSMB10 Gene

SuperPathways for PSMB10 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
2 RET signaling
3 Chks in Checkpoint Regulation
4 HIV Life Cycle
5 Class I MHC mediated antigen processing and presentation
genes like me logo Genes that share pathways with PSMB10: view

Gene Ontology (GO) - Biological Process for PSMB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002376 immune system process IEA --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
genes like me logo Genes that share ontologies with PSMB10: view

No data available for SIGNOR curated interactions for PSMB10 Gene

Drugs & Compounds for PSMB10 Gene

(6) Drugs for PSMB10 Gene - From: DrugBank, DGIdb, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
carfilzomib Approved, Investigational Pharma other, Inhibitor, Target Other, 20S Proteasome Inhibitor 0
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 826
Kyprolis Approved July 2012 Pharma 0
Celastrol Pharma Antioxidant, anti-inflammatory and immunosuppressive agent 0
Dihydroeponemycin Pharma Proteasome inhibitor,antitumor reagent,eponemycin ddrivative 0
genes like me logo Genes that share compounds with PSMB10: view

Transcripts for PSMB10 Gene

mRNA/cDNA for PSMB10 Gene

Unigene Clusters for PSMB10 Gene

Proteasome (prosome, macropain) subunit, beta type, 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMB10 Gene

No ASD Table

Relevant External Links for PSMB10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PSMB10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSMB10 Gene

mRNA differential expression in normal tissues according to GTEx for PSMB10 Gene

This gene is overexpressed in Whole Blood (x9.6).

Protein differential expression in normal tissues from HIPED for PSMB10 Gene

This gene is overexpressed in Lymph node (12.1), Peripheral blood mononuclear cells (8.2), and Tlymphocyte (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMB10 Gene

Protein tissue co-expression partners for PSMB10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PSMB10 Gene:


SOURCE GeneReport for Unigene cluster for PSMB10 Gene:


Evidence on tissue expression from TISSUES for PSMB10 Gene

  • Intestine(4.4)
  • Liver(4.3)
  • Lung(3)
  • Spleen(2.8)
  • Blood(2.5)
  • Lymph node(2.5)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with PSMB10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMB10 Gene

Orthologs for PSMB10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PSMB10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PSMB10 34 33
  • 99.39 (n)
(Bos Taurus)
Mammalia PSMB10 34 33
  • 86.94 (n)
(Canis familiaris)
Mammalia PSMB10 34 33
  • 85.1 (n)
(Mus musculus)
Mammalia Psmb10 16 34 33
  • 83.52 (n)
(Rattus norvegicus)
Mammalia Psmb10 33
  • 82.54 (n)
(Monodelphis domestica)
Mammalia PSMB10 34
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia PSMB10 34
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489016 33
  • 58.33 (n)
(Danio rerio)
Actinopterygii zgc:92791 33
  • 66.67 (n)
PSMB10 34
  • 62 (a)
Dr.15777 33
fruit fly
(Drosophila melanogaster)
Insecta CG18341 35
  • 49 (a)
Prosbeta2 34
  • 48 (a)
Prosbeta2R1 34
  • 41 (a)
(Caenorhabditis elegans)
Secernentea pbs-2 34
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PUP1 34
  • 46 (a)
Species where no ortholog for PSMB10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSMB10 Gene

Gene Tree for PSMB10 (if available)
Gene Tree for PSMB10 (if available)
Evolutionary constrained regions (ECRs) for PSMB10: view image

Paralogs for PSMB10 Gene

Paralogs for PSMB10 Gene

(3) SIMAP similar genes for PSMB10 Gene using alignment to 3 proteins:

  • Q6IB22_HUMAN
genes like me logo Genes that share paralogs with PSMB10: view

Variants for PSMB10 Gene

Sequence variations from dbSNP and Humsavar for PSMB10 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1001085577 -- 67,935,995(-) C/T coding_sequence_variant, synonymous_variant
rs1001271194 -- 67,935,771(-) C/A intron_variant
rs1001769119 -- 67,936,207(-) A/C intron_variant
rs1003119222 -- 67,937,766(-) C/G upstream_transcript_variant
rs1003665921 -- 67,938,318(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PSMB10 Gene

Variant ID Type Subtype PubMed ID
nsv522852 CNV gain 19592680
nsv524363 CNV loss 19592680

Variation tolerance for PSMB10 Gene

Residual Variation Intolerance Score: 39.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PSMB10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMB10 Gene

Disorders for PSMB10 Gene

Additional Disease Information for PSMB10

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PSMB10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMB10 Gene

Publications for PSMB10 Gene

  1. CD40 induces antigen transporter and immunoproteasome gene expression in carcinomas via the coordinated action of NF-kappaB and of NF-kappaB-mediated de novo synthesis of IRF-1. (PMID: 18694960) Moschonas A … Eliopoulos AG (Molecular and cellular biology 2008) 3 4 22 58
  2. Constitutive and interferon-gamma-induced expression of the human proteasome subunit multicatalytic endopeptidase complex-like 1. (PMID: 9551082) Foss GS … Prydz H (Biochimica et biophysica acta 1998) 3 4 22 58
  3. A tight cluster of five unrelated human genes on chromosome 16q22.1. (PMID: 8268911) Larsen F … Prydz H (Human molecular genetics 1993) 2 3 4 58
  4. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PMID: 22412388) Kenny EE … Peter I (PLoS genetics 2012) 3 44 58
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58

Products for PSMB10 Gene