PSMB10 Gene (Protein Coding)

Proteasome 20S Subunit Beta 10

GCID:: GC16M067937

GIFtS:: 44

Genes Participants

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiq... See more...

Aliases for PSMB10 Gene

Proteasome 20S Subunit Beta 10 ² ³
Proteasome Subunit Beta 10 ² ³ ⁵
Proteasome (Prosome, Macropain) Subunit, Beta Type, 10 ² ³
Multicatalytic Endopeptidase Complex Subunit MECl-1 ³ ⁴
Proteasome Subunit Beta Type-10 ³ ⁴
Low Molecular Mass Protein 10 ³ ⁴
Proteasome Subunit Beta-2i ³ ⁴
Macropain Subunit MECl-1 ³ ⁴
Proteasome MECl-1 ³ ⁴

EC 3.4.25.1 ⁴ ⁵²
MECL1 ³ ⁴
LMP10 ³ ⁴
Proteasome Catalytic Subunit 2i ³
Proteasome Subunit Beta 7i ³
Proteasome Subunit Beta2i ³
Proteasome Subunit MECL1 ³
Proteasome Subunit Β2i ²
Beta2i ³

External Ids for PSMB10 Gene

HGNC: 9538
Entrez Gene: 5699
Ensembl: ENSG00000205220
OMIM: 176847
UniProtKB: P40306

Previous HGNC Symbols for PSMB10 Gene

MECL1

Previous GeneCards Identifiers for PSMB10 Gene

GC16M058663
GC16M068342
GC16M067699
GC16M067739
GC16M066520
GC16M066525
GC16M067968
GC16M053841

Search aliases for PSMB10 gene in PubMed and other databases

Summaries for PSMB10 Gene

Entrez Gene Summary for PSMB10 Gene

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Proteolytic processing is required to generate a mature subunit. Expression of this gene is induced by gamma interferon, and this gene product replaces catalytic subunit 2 (proteasome beta 7 subunit) in the immunoproteasome. [provided by RefSeq, Jul 2008]

GeneCards Summary for PSMB10 Gene

PSMB10 (Proteasome 20S Subunit Beta 10) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and RET signaling. Gene Ontology (GO) annotations related to this gene include threonine-type endopeptidase activity. An important paralog of this gene is PSMB7.

UniProtKB/Swiss-Prot Summary for PSMB10 Gene

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides.
- PSB10_HUMAN,P40306

Gene Wiki entry for PSMB10 Gene

Additional gene information for PSMB10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSMB10 Gene

Genomics for PSMB10 Gene

GeneHancer (GH) Regulatory Elements for PSMB10 Gene

Promoters and enhancers for PSMB10 Gene

GeneHancer (GH) Identifier	GH Type	GH Score	GH Sources	Gene Association Score	Total Score	TSS distance (kb)	Number of Genes Away	Size (kb)	Transcription Factor Binding Sites
GH16J067934	Promoter/Enhancer	2.2	EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER	500.7	+0.6	610	4	FOXK2 ZBTB40 SIN3A NRF1 MYC POLR2G USF1 SP1 NCOR1 GTF2E2	ENSG00000261884 PSMB10 lnc-PSKH1-1 PSKH1 E2F4 CTCF EDC4 NFATC3 SLC12A4 RANBP10
GH16J068004	Promoter/Enhancer	1.4	FANTOM5 Ensembl ENCODE dbSUPER	11.6	-69.0	-69019	2.9	KLF4 NR2F2 CEBPG SAP130 ZNF592 SPI1 ELF1 MYC CEBPB ZBTB33	ENSG00000262962 KARS1P3 DPEP2 NFATC3 DPEP3 PSMB10 PRMT7 PARD6A ACD LCAT
GH16J067992	Promoter/Enhancer	2.3	EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER	6.4	-58.0	-58002	4.1	HNRNPK ZNF217 CTCF NRF1 POLR2G SP1 ZIC2 CLOCK ZNF263 ZNF423	DPEP2 PRMT7 ACD DDX28 KIAA0895L RNU6-359P SLC12A4 LCAT DUS2 NFATC3
GH16J067527	Promoter/Enhancer	2.3	FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER	5.7	+406.6	406551	5	HNRNPK ZBTB40 NRF1 ZNF300 POLR2G PHF8 JUND FOS ZFX ZIC2	ENSG00000276075 LOC100505942 ATP6V0D1 EDC4 ZDHHC1 ENKD1 CENPT C16orf70 E2F4 RANBP10
GH16J067479	Promoter/Enhancer	2.6	EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER	4.4	+455.1	455111	5.5	RXRA FOXK2 ZNF217 EP300 CTCF SIN3A NRF1 TCF12 MYC ZNF300	ATP6V0D1 LOC101927837 lnc-AGRP-6 ZDHHC1 ENKD1 NAE1 RIPOR1 ACD CARMIL2 C16orf86

- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSMB10 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PSMB10

Top Transcription factor binding sites by QIAGEN in the PSMB10 gene promoter:

COMP1
E47
GR
GR-alpha
GR-beta
LCR-F1
p53

Genomic Locations for PSMB10 Gene

chr16:67,934,504-67,936,877: (GRCh38/hg38)

Size:: 2,374 bases
Orientation:: Minus strand

chr16:67,968,405-67,970,990: (GRCh37/hg19)

Size:: 2,586 bases
Orientation:: Minus strand

Genomic View for PSMB10 Gene

Genes around PSMB10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:

16q22.1 by HGNC
16q22.1 by Entrez Gene
16q22.1 by Ensembl

PSMB10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

Genomic Location for PSMB10 Gene — Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PSMB10 Gene

NC_000016.10

Proteins for PSMB10 Gene

Protein details for PSMB10 Gene (UniProtKB/Swiss-Prot)
Protein Symbol:

P40306-PSB10_HUMAN

Recommended name:

Proteasome subunit beta type-10

Protein Accession:

P40306

Secondary Accessions:
- B2R5J4
- Q5U098
Protein attributes for PSMB10 Gene
Size:

273 amino acids

Molecular mass:

28936 Da
Quaternary structure:
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Component of the immunoproteasome, where it displaces the equivalent housekeeping subunit PSMB7. Component of the spermatoproteasome, a form of the proteasome specifically found in testis.

(Microbial infection) Interacts with HIV-1 TAT protein.
Three dimensional structures from OCA and Proteopedia for PSMB10 Gene
- 6AVO (3D)
- 6E5B (3D)
- 6HV3 (3D)
- 6HV4 (3D)
- 6HV5 (3D)
- 6HV7 (3D)

neXtProt entry for PSMB10 Gene

Protein Expression for PSMB10 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for PSMB10 Gene

P40306:

LGADTRAT
IYCCGAG

Post-translational modifications for PSMB10 Gene

Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile proteolytic activity.
- P40306-PSB10_HUMAN
Ubiquitination at Lys31, Lys37, Lys68, Lys72, Lys79, Lys101, and Lys236
- NX_P40306 (NX_P40306-1)
Modification sites at PhosphoSitePlus
- P40306

Other Protein References for PSMB10 Gene

ENSEMBL proteins:

REFSEQ proteins:

NP_002792.1

Antibody Products

LifeSpan BioSciences PSMB10 Antibody

Creative Diagnostics Anti-PSMB10 monoclonal antibody, clone FQS25013

Creative Biolabs Recombinant Anti-Human PSMB10 Antibody

GeneTex Anti-PSMB10 antibody, Internal and Anti-PSMB10 antibody

Human PSMB10/MECL1 Antibody (AF7684)

OriGene Antibodies for PSMB10
Custom Antibody Services

Novus Biologicals Antibodies for PSMB10

Abcam antibodies for PSMB10
- PSMB10

Invitrogen Antibodies for PSMB10 (AFLGC-PSMB10)

antibodies-online: Show 18 available PSMB10 Antibodies ranked by validation data
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Biorbyt antibodies for PSMB10
- orb20246
- orb340916

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Santa Cruz Biotechnology (SCBT) Antibodies for PSMB10
- MECL-1 (C-2)

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Protein Products

Creative Biomart Recombinant Human PSMB10, His-tagged

OriGene Purified Proteins for PSMB10
Search Origene for MassSpec and Protein Over-expression Lysates for PSMB10
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Novus Biologicals proteins for PSMB10

ProSpec Recombinant Proteins for PSMB10

antibodies-online: Show 7 available PSMB10 Proteins ranked by validation data
Compare Top PSMB10 Proteins

Signalway Proteins for PSMB10
- AP76874

Search for PSMB10 Proteins at ProSci

Abcam proteins for PSMB10
- PSMB10

Assay Products

antibodies-online: Show 3 available PSMB10 Elisa Kits ranked by validation data
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Quality Products:

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Domains & Families for PSMB10 Gene

Gene Families for PSMB10 Gene

HGNC:

Proteasome

Human Protein Atlas (HPA):

Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Protein Domains for PSMB10 Gene

Blocks:

Proteasome B-type subunit

InterPro:

ProtoNet:

P40306

Suggested Antigen Peptide Sequences for PSMB10 Gene

GenScript: Design optimal peptide antigens:

Proteasome subunit beta-2i (PSB10_HUMAN)
Proteasome subunit beta type (Q6IB22_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P40306

UniProtKB/Swiss-Prot:

PSB10_HUMAN :

Belongs to the peptidase T1B family.

Family:

Belongs to the peptidase T1B family.

Function for PSMB10 Gene

Molecular function for PSMB10 Gene

UniProtKB/Swiss-Prot Function:

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides.

PSB10_HUMAN,P40306

UniProtKB/Swiss-Prot CatalyticActivity:

Reaction=Cleavage of peptide bonds with very broad specificity.; EC=3.4.25.1;.

PSB10_HUMAN,P40306

UniProtKB/Swiss-Prot Induction:

Up-regulated by IFNG/IFN-gamma (at protein level). Up-regulated by IRF1. Up-regulated by TNF (at protein level). Up-regulated by tetrodotoxin (TTX) in glial cells. Up-regulated in Crohn's bowel disease (CD). Up-regulated by CD40L via the NFKB1 pathway in cancer cells.

PSB10_HUMAN,P40306

GENATLAS Biochemistry:

multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,beta-type subunit MECL-1,29kDa,interferon gamma inducible

PSMB10

Enzyme Numbers (IUBMB) for PSMB10 Gene

EC 3.4.25.1 ⁵² ⁴

Phenotypes From GWAS Catalog for PSMB10 Gene

Gene Ontology (GO) - Molecular Function for PSMB10 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004175	endopeptidase activity	IBA,IEA	21873635
GO:0004298	threonine-type endopeptidase activity	IEA	--
GO:0005515	protein binding	IPI	14733938
GO:0008233	peptidase activity	IEA	--
GO:0016787	hydrolase activity	IEA	--

Phenotypes for PSMB10 Gene

MGI mutant phenotypes for PSMB10:

inferred from 2 alleles

GenomeRNAi human phenotypes for PSMB10:

Animal Models for PSMB10 Gene

MGI Knock Outs for PSMB10:

Psmb10 ^{Psmb10<tm1Mgro>}

Animal Model Products

Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study

CRISPR Products

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OriGene CRISPR knockouts for PSMB10
- GA103868
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- KN400437
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genomics-online: gRNA clones - Search for available PSMB10 gRNA products
Overview of 112 available PSMB10 gene related products
Recommended
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Santa Cruz Biotechnology (SCBT) CRISPR for PSMB10

miRNA Products

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Inhibitory RNA Products

Origene shrna, sirna, and RNAi products in human, mouse, rat for PSMB10
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genomics-online: shRNA clones - Search for available PSMB10 shRNA products
Overview of 112 available PSMB10 gene related products
Recommended
- pCMV6-Entry
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- pDONR223
- pPM-C-HA
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- pPB-N-His

Search Santa Cruz Biotechnology (SCBT) for PSMB10 siRNA/shRNA

Clone Products

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OriGene clones in human,mouse,rat for PSMB10
- SC200421
- MC207361
- RN213411
- SC102824
OriGene ORF clones in human,mouse,rat for PSMB10
- MG203661
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- MR203661L3
- MR203661L4
- RC200437
- RC200437L3
- RC200437L4
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- RR213411
- RR213411L3
- RR213411L4
- MR203661L3V
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- RC200437L3V
- RC200437L4V
- RR213411L3V
- RR213411L4V
Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling

Sino Biological Human cDNA Clone for PSMB10

Addgene plasmids for PSMB10

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genomics-online: cdna clones - Search for available PSMB10 CDNA products
Overview of 112 available PSMB10 gene related products
Recommended
- pCMV6-Entry
- pCMV-SPORT6
- pOTB7
- pExpress-1
- pORF
- pDONR223
- pPM-C-HA
- pPM-C-His
- pPB-N-His
orf clones - Search for available PSMB10 ORF products
Overview of 112 available PSMB10 gene related products
Recommended
- pCMV6-Entry
- pCMV-SPORT6
- pOTB7
- pExpress-1
- pORF
- pDONR223
- pPM-C-HA
- pPM-C-His
- pPB-N-His

Cell Line Products

Browse ESI BIO Cell Lines and PureStem Progenitors for PSMB10

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VectorBuilder Stable cell line generation for PSMB10

Horizon Cell Lines for PSMB10
- PSMB10 knockout cell line
- PSMB10 knockout cell line

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PSMB10 Gene

Localization for PSMB10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMB10 Gene

Cytoplasm. Nucleus.

P40306-PSB10_HUMAN

Subcellular locations from

COMPARTMENTS

Compartment	Confidence
nucleus	5
cytosol	5
plasma membrane	2
endoplasmic reticulum	2
extracellular	1
cytoskeleton	1
mitochondrion	1
endosome	1
lysosome	1
golgi apparatus	1

Subcellular locations from the

Human Protein Atlas (HPA)

Cytosol (3)
Vesicles (2)

See all subcellular structures

Gene Ontology (GO) - Cellular Components for PSMB10 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000502	proteasome complex	TAS	9551082
GO:0005634	nucleus	IBA	21873635
GO:0005654	nucleoplasm	TAS	--
GO:0005737	cytoplasm	IBA	21873635
GO:0005829	cytosol	TAS	--

Pathways & Interactions for PSMB10 Gene

SuperPathways for PSMB10 Gene

	SuperPathway	Contained pathways
1	CDK-mediated phosphorylation and removal of Cdc6	Activation of APC/C and APC/C-Cdc20 mediated degradation of mitotic proteins .95 Cdc20-Phospho-APC/C mediated degradation of Cyclin A .95 Autodegradation of the E3 ubiquitin ligase COP1 .95 Stabilization of p53 .95 Regulation of activated PAK-2p34 by proteasome mediated degradation .94 Regulation of Apoptosis .94 CDK-mediated phosphorylation and removal of Cdc6 .94 Ubiquitin-dependent degradation of Cyclin D .94 Ubiquitin-dependent degradation of Cyclin D1 .94 Orc1 removal from chromatin .94 Regulation of DNA replication .94 Switching of origins to a post-replicative state .94 Cyclin A-Cdk2-associated events at S phase entry .93 Cyclin E associated events during G1/S transition .93 APC/C-Cdc20 mediated degradation of Securin .93 APC/C-Cdh1 mediated degradation of Cdc20 and other APC/C-Cdh1 targeted proteins in late mitosis/early G1 .93 APC/C-mediated degradation of cell cycle proteins .93 Regulation of APC/C activators between G1/S and early anaphase .93 Regulation of mitotic cell cycle .93 DNA Replication .93 Synthesis of DNA .93 Vpu mediated degradation of CD4 .93 Autodegradation of Cdh1 by Cdh1-APC/C .91 SCF-beta-TrCP mediated degradation of Emi1 .91 p53-Independent DNA Damage Response .91 p53-Independent G1/S DNA damage checkpoint .91 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A .91 ABC transporter disorders .91 Disorders of transmembrane transporters .91 Defective CFTR causes cystic fibrosis .90 Assembly of the pre-replicative complex .90 Hedgehog ligand biogenesis .90 Hh mutants abrogate ligand secretion .90 APC/C-Cdc20 mediated degradation of mitotic proteins .89 APC-Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint .89 Vif-mediated degradation of APOBEC3G .89 Degradation of GLI1 by the proteasome .89 Degradation of GLI2 by the proteasome .89 GLI3 is processed to GLI3R by the proteasome .89	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis .88 Degradation of AXIN .88 Cellular response to hypoxia .87 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha .87 Regulation of Hypoxia-inducible Factor (HIF) by oxygen .87 CDT1 association with the CDC6-ORC-origin complex .87 Hh mutants that dont undergo autocatalytic processing are degraded by ERAD .87 AUF1 (hnRNP D0) binds and destabilizes mRNA .86 p53-Dependent G1 DNA Damage Response .86 p53-Dependent G1/S DNA damage checkpoint .86 SCF(Skp2)-mediated degradation of p27/p21 .86 Removal of licensing factors from origins .86 NIK-->noncanonical NF-kB signaling .85 Dectin-1 mediated noncanonical NF-kB signaling .84 G1/S DNA Damage Checkpoints .84 Degradation of DVL .83 Cross-presentation of soluble exogenous antigens (endosomes) .82 The role of GTSE1 in G2/M progression after G2 checkpoint .81 Regulation of ornithine decarboxylase (ODC) .81 DNA Replication Pre-Initiation .80 M/G1 Transition .80 Proteasome .78 S Phase .78 Activation of NF-kappaB in B cells .77 Asymmetric localization of PCP proteins .74 FCERI mediated NF-kB activation .72 Regulation of RAS by GAPs .70 PCP/CE pathway .70 Beta-catenin independent WNT signaling .64 Degradation of beta-catenin by the destruction complex .64 Regulation of mRNA stability by proteins that bind AU-rich elements .63 Metabolism of polyamines .60 ABC-family proteins mediated transport .58 TNFR2 non-canonical NF-kB pathway .58 MAPK6/MAPK4 signaling .57 Proteasome Degradation .56 UCH proteinases .47 Apoptosis .31 Programmed Cell Death .31
2	RET signaling	Frs2-mediated activation .95 GRB2 events in EGFR signaling .95 MAPK1/MAPK3 signaling .95 Prolonged ERK activation events .95 RAF/MAP kinase cascade .95 SHC1 events in EGFR signaling .95 Signaling by Leptin .95 SOS-mediated signalling .95 VEGFR2 mediated cell proliferation .95 ARMS-mediated activation .95 Signalling to ERKs .95 Signalling to p38 via RIT and RIN .95 Signalling to RAS .95 Interleukin receptor SHC signaling .95 Interleukin-3, 5 and GM-CSF signaling .94 Interleukin-2 signaling .94 Downstream signal transduction .94 Signaling by PDGF .94 DAP12 signaling .92	RET signaling .92 Insulin receptor signalling cascade .92 Signaling by Insulin receptor .92 IRS-mediated signalling .91 Signaling by EGFR .90 FCERI mediated MAPK activation .90 IGF1R signaling cascade .90 IRS-related events triggered by IGF1R .90 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) .90 DAP12 interactions .89 NCAM signaling for neurite out-growth .89 NGF signalling via TRKA from the plasma membrane .87 MAPK family signaling cascades .87 Signaling by SCF-KIT .85 Signalling by NGF .81 Fc epsilon receptor (FCERI) signaling .79 VEGFA-VEGFR2 Pathway .78 Signaling by VEGF .76 Gastrin-CREB signalling pathway via PKC and MAPK .55
3	Chks in Checkpoint Regulation	Chks in Checkpoint Regulation .59 G2-M Phase Transition .59 Estrogen-mediated S-Phase Entry .55	SREBP Proteolysis .43 DNA Repair Mechanisms .32
4	HIV Life Cycle	HIV Infection .64 Infectious disease .61 Host Interactions of HIV factors .57	Disease .45 Diseases of signal transduction .43
5	Class I MHC mediated antigen processing and presentation	Antigen processing- Ubiquitination and Proteasome degradation .83 Class I MHC mediated antigen processing and presentation .83	Adaptive Immune System .45

Pathways by source for PSMB10 Gene

1 BioSystems pathway for PSMB10 Gene

Proteasome Degradation

164 Reactome pathways for PSMB10 Gene

1 KEGG pathway for PSMB10 Gene

Proteasome

1 GeneGo (Thomson Reuters) pathway for PSMB10 Gene

Immune response Antigen presentation by MHC class I

12 Qiagen pathways for PSMB10 Gene

CDK5 Pathway
Chks in Checkpoint Regulation
DNA Repair Mechanisms
Estrogen-mediated S-Phase Entry
G2-M Phase Transition

Interacting Proteins for PSMB10 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)

Selected Interacting proteins: P40306-PSB10_HUMAN ENSP00000351314 for PSMB10 Gene via UniProtKB MINT STRING IID

Symbol	External ID(s)	Details
CCNDBP1	O95273 ⁴ ²⁰ ¹²⁷	EBI-603329, EBI-748961 MINT-8168294 IID: # exp=2
PSMB3	P49720 ⁴ ¹²⁷ ENSP00000483688 ²¹	EBI-603329, EBI-603340 STRING: ENSP00000483688 IID: # exp=6 # pred=3
ANAPC1	ENSP00000339109 ²¹ Q9H1A4 ¹²⁷	STRING: ENSP00000339109 IID: # pred=1
ANAPC10	ENSP00000478501 ²¹ Q9UM13 ¹²⁷	STRING: ENSP00000478501 IID: # pred=1
ANAPC11	ENSP00000349957 ²¹ Q9NYG5 ¹²⁷	STRING: ENSP00000349957 IID: # pred=1

GPS-Prot Interaction Network for PSMB10

;

Gene Ontology (GO) - Biological Process for PSMB10 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000165	MAPK cascade	TAS	--
GO:0000209	protein polyubiquitination	TAS	--
GO:0000902	cell morphogenesis	IEA	--
GO:0002223	stimulatory C-type lectin receptor signaling pathway	TAS	--
GO:0002376	immune system process	IEA	--

No data available for SIGNOR curated interactions for PSMB10 Gene

Drugs & Compounds for PSMB10 Gene

(5) Drugs for PSMB10 Gene - From: DrugBank, ApexBio, and DGIdb

Name	Status	Disease Links	Group	Role	Mechanism of Action	Clinical Trials
carfilzomib	Approved, Investigational	MalaCards Medline Plus	Pharma	Target, inhibitor, other	Other, 20S Proteasome Inhibitor	0
Bortezomib	Approved, Investigational	MalaCards Medline Plus	Pharma	inhibitor, other	Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors	888
Celastrol		MalaCards Medline Plus	Pharma		Antioxidant, anti-inflammatory and immunosuppressive agent	0
Dihydroeponemycin		MalaCards Medline Plus	Pharma		Proteasome inhibitor,antitumor reagent,eponemycin ddrivative	0
MLN2238		MalaCards Medline Plus	Pharma		β5 site of the 20S proteasome inhibitor	0

(3) ApexBio Compounds for PSMB10 Gene

Compound	Action	Cas Number
Celastrol	Antioxidant, anti-inflammatory and immunosuppressive agent	34157-83-0
Dihydroeponemycin	Proteasome inhibitor,antitumor reagent,eponemycin ddrivative	126463-64-7
MLN2238	β5 site of the 20S proteasome inhibitor	1072833-77-2

Drug Products

Creative Biomart Recombinant Human PSMB10, His-tagged

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ApexBio compounds for PSMB10

Transcripts for PSMB10 Gene