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The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiq... See more...
Aliases for PSMB10 Gene
Aliases for PSMB10 Gene
- Proteasome 20S Subunit Beta 10 2 3 5
- LMP10 2 3 4
- Proteasome (Prosome, Macropain) Subunit, Beta Type, 10 2 3
- Multicatalytic Endopeptidase Complex Subunit MECl-1 3 4
- Proteasome Subunit Beta Type-10 3 4
- Low Molecular Mass Protein 10 3 4
- Proteasome Subunit Beta 10 2 3
- Proteasome Subunit Beta-2i 3 4
- Macropain Subunit MECl-1 3 4
- Proteasome MECl-1 3 4
External Ids for PSMB10 Gene
- HGNC: 9538
- NCBI Entrez Gene: 5699
- Ensembl: ENSG00000205220
- OMIM®: 176847
- UniProtKB/Swiss-Prot: P40306
Previous HGNC Symbols for PSMB10 Gene
- MECL1
Previous GeneCards Identifiers for PSMB10 Gene
- GC16M058663
- GC16M068342
- GC16M067699
- GC16M067739
- GC16M066520
- GC16M066525
- GC16M067968
- GC16M053841
Summaries for PSMB10 Gene
-
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Proteolytic processing is required to generate a mature subunit. Expression of this gene is induced by gamma interferon, and this gene product replaces catalytic subunit 2 (proteasome beta 7 subunit) in the immunoproteasome. [provided by RefSeq, Jul 2008]
GeneCards Summary for PSMB10 Gene
PSMB10 (Proteasome 20S Subunit Beta 10) is a Protein Coding gene. Diseases associated with PSMB10 include Proteasome-Associated Autoinflammatory Syndrome 5 and Immunodeficiency 12. Among its related pathways are Downstream signaling events of B Cell Receptor (BCR) and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include threonine-type endopeptidase activity. An important paralog of this gene is PSMB7.
UniProtKB/Swiss-Prot Summary for PSMB10 Gene
-
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides.
Additional gene information for PSMB10 Gene
- HGNC (9538)
- NCBI Entrez Gene (5699)
- Ensembl (ENSG00000205220)
- OMIM® (176847)
- UniProtKB/Swiss-Prot (P40306)
- Open Targets Platform(ENSG00000205220)
- Monarch Initiative
- Search for PSMB10 at DataMed
- Search for PSMB10 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSMB10 Gene
Genomics for PSMB10 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PSMB10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PSMB10 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PSMB10
- Top Transcription factor binding sites by QIAGEN in the PSMB10 gene promoter:
-
- COMP1
- E47
- GR
- GR-alpha
- GR-beta
- LCR-F1
- p53
Genomic Locations for PSMB10 Gene
Latest Assembly
- chr16:67,934,506-67,936,864
- (GRCh38/hg38)
- Size:
- 2,359 bases
- Orientation:
- Minus strand
Previous Assembly
- chr16:67,968,409-67,970,753
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 2,345 bases
- Orientation:
- Minus strand
- chr16:67,968,405-67,970,990
- (GRCh37/hg19 by Ensembl)
- Size:
- 2,586 bases
- Orientation:
- Minus strand
Genomic View for PSMB10 Gene
Genes around PSMB10 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q22.1 by HGNC
- 16q22.1 by Entrez Gene
- 16q22.1 by Ensembl
PSMB10 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PSMB10 Gene
Proteins for PSMB10 Gene
-
Protein details for PSMB10 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P40306-PSB10_HUMAN
- Recommended name:
- Proteasome subunit beta type-10
- Protein Accession:
- P40306
- B2R5J4
- Q5U098
Protein attributes for PSMB10 Gene
- Size:
- 273 amino acids
- Molecular mass:
- 28936 Da
- Quaternary structure:
-
- The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Component of the immunoproteasome, where it displaces the equivalent housekeeping subunit PSMB7. Component of the spermatoproteasome, a form of the proteasome specifically found in testis.
- (Microbial infection) Interacts with HIV-1 TAT protein.
Protein Expression for PSMB10 Gene
Selected DME Specific Peptides for PSMB10 Gene
- P40306:
-
- LGADTRAT
- IYCCGAG
Post-translational modifications for PSMB10 Gene
- Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile proteolytic activity.
-
Ubiquitination at Lys31, Lys37, Lys68, Lys72, Lys79, Lys101, and Lys236
- NX_P40306 (NX_P40306-1)
- Modification sites at PhosphoSitePlus
Other Protein References for PSMB10 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences PSMB10 Antibody
- GeneTex Anti-PSMB10 antibody, Internal and Anti-PSMB10 antibody
-
Custom Antibody ServicesOriGene Antibodies for PSMB10
- Novus Biologicals Antibodies for PSMB10
-
Abcam antibodies for PSMB10
- Invitrogen Antibodies for PSMB10 (AFLGC-PSMB10)
-
Boster Bio Antibodies for PSMB10
-
Santa Cruz Biotechnology (SCBT) Antibodies for PSMB10
Protein products for research
-
OriGene Purified Proteins for PSMB10
- Search Origene for MassSpec and Protein Over-expression Lysates for PSMB10
- Origene Custom Protein Services for PSMB10
- Novus Biologicals proteins for PSMB10
- ProSpec Recombinant Proteins for PSMB10
-
Abcam proteins for PSMB10
Assay products for research
- antibodies-online: Show 3 available PSMB10 Elisa Kits ranked by validation data
- Compare Top PSMB10 Elisa Kits
-
Quality Products:
Domains & Families for PSMB10 Gene
Gene Families for PSMB10 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- FDA approved drug targets
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for PSMB10 Gene
- InterPro:
- Blocks:
-
- Proteasome B-type subunit
- ProtoNet:
Suggested Antigen Peptide Sequences for PSMB10 Gene
- GenScript: Design optimal peptide antigens:
-
- Proteasome subunit beta-2i (PSB10_HUMAN)
- Proteasome subunit beta type (Q6IB22_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P40306- Family:
-
- Belongs to the peptidase T1B family.
Function for PSMB10 Gene
Molecular function for PSMB10 Gene
- UniProtKB/Swiss-Prot Function:
- The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=Cleavage of peptide bonds with very broad specificity.; EC=3.4.25.1;.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated by IFNG/IFN-gamma (at protein level). Up-regulated by IRF1. Up-regulated by TNF (at protein level). Up-regulated by tetrodotoxin (TTX) in glial cells. Up-regulated in Crohn's bowel disease (CD). Up-regulated by CD40L via the NFKB1 pathway in cancer cells.
- GENATLAS Biochemistry:
- multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,beta-type subunit MECL-1,29kDa,interferon gamma inducible
Enzyme Numbers (IUBMB) for PSMB10 Gene
Phenotypes From GWAS Catalog for PSMB10 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004175 | endopeptidase activity | IEA,IBA | 21873635 |
| GO:0004298 | threonine-type endopeptidase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 14733938 |
| GO:0008233 | peptidase activity | IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for PSMB10 Gene
- MGI mutant phenotypes for PSMB10:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for PSMB10:
Animal Models for PSMB10 Gene
- MGI Knock Outs for PSMB10:
-
- Psmb10 Psmb10<tm1Mgro>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PSMB10 - Starting at $85 >
- * PSMB10 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PSMB10
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PSMB10
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSMB10
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PSMB10
- Browse OriGene Inhibitory RNA Products For PSMB10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMB10
Clone products for research
- Applied Biological Materials (abm): Clones for PSMB10 - Starting at $45 >
- * PSMB10 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for PSMB10
- Addgene plasmids for PSMB10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PSMB10
Cell Lines for research
-
Horizon Cell Lines for PSMB10
No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PSMB10 Gene
Localization for PSMB10 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PSMB10 Gene
- Cytoplasm. Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endosome | 1 |
| golgi apparatus | 1 |
- Cytosol (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000502 | proteasome complex | TAS | 9551082 |
| GO:0005634 | nucleus | IEA,IBA | 21873635 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IBA | 21873635 |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for PSMB10 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | CDK-mediated phosphorylation and removal of Cdc6 |
.93
.93
|
.80
.80
.78
.70
.47
.31
|
| 2 | RET signaling |
.92
|
.92
|
| 3 | Chks in Checkpoint Regulation |
Chks in Checkpoint Regulation
.59
G2-M Phase Transition
.59
Estrogen-mediated S-Phase Entry
.55
|
SREBP Proteolysis
.43
DNA Repair Mechanisms
.32
|
| 4 | HIV Life Cycle |
.64
|
.45
|
| 5 | Class I MHC mediated antigen processing and presentation | ||
Pathways by source for PSMB10 Gene
1 BioSystems pathway for PSMB10 Gene
164 Reactome pathways for PSMB10 Gene
1 KEGG pathway for PSMB10 Gene
1 GeneGo (Thomson Reuters) pathway for PSMB10 Gene
- Immune response Antigen presentation by MHC class I
12 Qiagen pathways for PSMB10 Gene
- CDK5 Pathway
- Chks in Checkpoint Regulation
- DNA Repair Mechanisms
- Estrogen-mediated S-Phase Entry
- G2-M Phase Transition
Interacting Proteins for PSMB10 Gene
Selected Interacting proteins:
P40306-PSB10_HUMAN
ENSP00000351314
for PSMB10 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for PSMB10
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0000902 | cell morphogenesis | IEA | -- |
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
| GO:0002376 | immune system process | IEA | -- |
No data available for SIGNOR curated interactions for PSMB10 Gene
Drugs & Compounds for PSMB10 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| carfilzomib | Approved, Investigational | Pharma | Target, inhibitor, other | Other, 20S Proteasome Inhibitor | 0 | |
| Bortezomib | Approved, Investigational | Pharma | inhibitor, other | Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors | 926 | |
| Celastrol | Pharma | Antioxidant, anti-inflammatory and immunosuppressive agent | 0 | |||
| Dihydroeponemycin | Pharma | Proteasome inhibitor,antitumor reagent,eponemycin ddrivative | 0 | |||
| MLN2238 | Pharma | β5 site of the 20S proteasome inhibitor | 0 |
(3) ApexBio Compounds for PSMB10 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Celastrol | Antioxidant, anti-inflammatory and immunosuppressive agent | 34157-83-0 |
| Dihydroeponemycin | Proteasome inhibitor,antitumor reagent,eponemycin ddrivative | 126463-64-7 |
| MLN2238 | β5 site of the 20S proteasome inhibitor | 1072833-77-2 |
Transcripts for PSMB10 Gene
mRNA/cDNA for PSMB10 Gene
- 1 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000358514 977 nts (view in UCSC)
- ENST00000570304 851 nts (view in UCSC)
- ENST00000570985 591 nts (view in UCSC)
- ENST00000574576 539 nts (view in UCSC)
- ENST00000575556 966 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PSMB10 - Starting at $85 >
- * PSMB10 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PSMB10
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PSMB10
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSMB10
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PSMB10
- Browse OriGene Inhibitory RNA Products For PSMB10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMB10
Clone products for research
- Applied Biological Materials (abm): Clones for PSMB10 - Starting at $45 >
- * PSMB10 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for PSMB10
- Addgene plasmids for PSMB10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PSMB10
Relevant External Links for PSMB10 Gene
- GeneLoc Exon Structure for
- PSMB10
Expression for PSMB10 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Tonsil (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for PSMB10 Gene
This gene is overexpressed in Whole Blood (x9.6).
This gene is overexpressed in Lymph node (12.1), Peripheral blood mononuclear cells (8.2), and Tlymphocyte (6.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMB10 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PSMB10
SOURCE GeneReport for Unigene cluster for PSMB10 Gene:
Hs.9661Evidence on tissue expression from TISSUES for PSMB10 Gene
- Intestine(4.5)
- Liver(4.4)
- Lung(3.3)
- Spleen(2.9)
- Lymph node(2.9)
- Blood(2.8)
- Nervous system(2.6)
- Heart(2.5)
- Muscle(2.5)
- Bone marrow(2.4)
- Skin(2.2)
- Kidney(2.2)
- Pancreas(2.1)
- Stomach(2)
Primer products for research
-
OriGene qPCR primer pairs for PSMB10
-
OriGene qPCR primer pairs and template standards for PSMB10
Gene Expression Assays for research
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMB10 Gene
Orthologs for PSMB10 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PSMB10 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PSMB10 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PSMB10 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Psmb10 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Psmb10 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | PSMB10 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | PSMB10 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100489016 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | zgc:92791 30 |
|
||
| PSMB10 31 |
|
OneToOne | |||
| Dr.15777 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG18341 32 |
|
|
|
| Prosbeta2 31 |
|
ManyToMany | |||
| Prosbeta2R1 31 |
|
ManyToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | pbs-2 31 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PUP1 31 |
|
OneToMany |
- Species where no ortholog for PSMB10 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for PSMB10 Gene
- ENSEMBL:
- Gene Tree for PSMB10 (if available)
- TreeFam:
- Gene Tree for PSMB10 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PSMB10: view image
Paralogs for PSMB10 Gene
Paralogs for PSMB10 Gene
(3) SIMAP similar genes for PSMB10 Gene using alignment to 3 proteins:
- PSB10_HUMAN
- J3QQN1_HUMAN
- Q6IB22_HUMAN
Variants for PSMB10 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
39.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.13;
22.91% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PSMB10 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PSMB10
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PSMB10 Gene
Disorders for PSMB10 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| proteasome-associated autoinflammatory syndrome 5 |
|
|
| immunodeficiency 12 |
|
|
Search PSMB10 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PSMB10
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PSMB10 Gene
Publications for PSMB10 Gene
- CD40 induces antigen transporter and immunoproteasome gene expression in carcinomas via the coordinated action of NF-kappaB and of NF-kappaB-mediated de novo synthesis of IRF-1. (PMID: 18694960) Moschonas A … Eliopoulos AG (Molecular and cellular biology 2008) 3 4 23
- Constitutive and interferon-gamma-induced expression of the human proteasome subunit multicatalytic endopeptidase complex-like 1. (PMID: 9551082) Foss GS … Prydz H (Biochimica et biophysica acta 1998) 3 4 23
- A tight cluster of five unrelated human genes on chromosome 16q22.1. (PMID: 8268911) Larsen F … Prydz H (Human molecular genetics 1993) 2 3 4
- A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PMID: 22412388) Kenny EE … Peter I (PLoS genetics 2012) 3 41
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
ExternalLinks
Products for PSMB10 Gene
- Custom Antibody ServicesOriGene Antibodies for PSMB10
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for PSMB10
- Search Origene for MassSpec and Protein Over-expression Lysates for PSMB10
- Origene Custom Protein Services for PSMB10
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PSMB10
- Browse OriGene Inhibitory RNA Products For PSMB10
- OriGene qPCR primer pairs for PSMB10
- OriGene qPCR primer pairs and template standards for PSMB10
- OriGene CRISPR knockouts for PSMB10
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PSMB10