The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiq... See more...

Aliases for PSMB10 Gene

Aliases for PSMB10 Gene

  • Proteasome 20S Subunit Beta 10 2 3
  • Proteasome Subunit Beta 10 2 3 5
  • Proteasome (Prosome, Macropain) Subunit, Beta Type, 10 2 3
  • Multicatalytic Endopeptidase Complex Subunit MECl-1 3 4
  • Proteasome Subunit Beta Type-10 3 4
  • Low Molecular Mass Protein 10 3 4
  • Proteasome Subunit Beta-2i 3 4
  • Macropain Subunit MECl-1 3 4
  • Proteasome MECl-1 3 4
  • EC 3.4.25.1 4 52
  • MECL1 3 4
  • LMP10 3 4
  • Proteasome Catalytic Subunit 2i 3
  • Proteasome Subunit Beta 7i 3
  • Proteasome Subunit Beta2i 3
  • Proteasome Subunit MECL1 3
  • Proteasome Subunit Β2i 2
  • Beta2i 3

External Ids for PSMB10 Gene

Previous HGNC Symbols for PSMB10 Gene

  • MECL1

Previous GeneCards Identifiers for PSMB10 Gene

  • GC16M058663
  • GC16M068342
  • GC16M067699
  • GC16M067739
  • GC16M066520
  • GC16M066525
  • GC16M067968
  • GC16M053841

Summaries for PSMB10 Gene

Entrez Gene Summary for PSMB10 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Proteolytic processing is required to generate a mature subunit. Expression of this gene is induced by gamma interferon, and this gene product replaces catalytic subunit 2 (proteasome beta 7 subunit) in the immunoproteasome. [provided by RefSeq, Jul 2008]

GeneCards Summary for PSMB10 Gene

PSMB10 (Proteasome 20S Subunit Beta 10) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and RET signaling. Gene Ontology (GO) annotations related to this gene include threonine-type endopeptidase activity. An important paralog of this gene is PSMB7.

UniProtKB/Swiss-Prot Summary for PSMB10 Gene

  • The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides.

Gene Wiki entry for PSMB10 Gene

Additional gene information for PSMB10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSMB10 Gene

Genomics for PSMB10 Gene

GeneHancer (GH) Regulatory Elements for PSMB10 Gene

Promoters and enhancers for PSMB10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSMB10 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PSMB10

Top Transcription factor binding sites by QIAGEN in the PSMB10 gene promoter:
  • COMP1
  • E47
  • GR
  • GR-alpha
  • GR-beta
  • LCR-F1
  • p53

Genomic Locations for PSMB10 Gene

Genomic Locations for PSMB10 Gene
chr16:67,934,504-67,936,877
(GRCh38/hg38)
Size:
2,374 bases
Orientation:
Minus strand
chr16:67,968,405-67,970,990
(GRCh37/hg19)
Size:
2,586 bases
Orientation:
Minus strand

Genomic View for PSMB10 Gene

Genes around PSMB10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMB10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMB10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMB10 Gene

Proteins for PSMB10 Gene

  • Protein details for PSMB10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40306-PSB10_HUMAN
    Recommended name:
    Proteasome subunit beta type-10
    Protein Accession:
    P40306
    Secondary Accessions:
    • B2R5J4
    • Q5U098

    Protein attributes for PSMB10 Gene

    Size:
    273 amino acids
    Molecular mass:
    28936 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Component of the immunoproteasome, where it displaces the equivalent housekeeping subunit PSMB7. Component of the spermatoproteasome, a form of the proteasome specifically found in testis.
    • (Microbial infection) Interacts with HIV-1 TAT protein.

    Three dimensional structures from OCA and Proteopedia for PSMB10 Gene

neXtProt entry for PSMB10 Gene

Selected DME Specific Peptides for PSMB10 Gene

P40306:
  • LGADTRAT
  • IYCCGAG

Post-translational modifications for PSMB10 Gene

  • Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile proteolytic activity.
  • Ubiquitination at Lys31, Lys37, Lys68, Lys72, Lys79, Lys101, and Lys236
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMB10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PSMB10 Gene

Gene Families for PSMB10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PSMB10 Gene

Suggested Antigen Peptide Sequences for PSMB10 Gene

GenScript: Design optimal peptide antigens:
  • Proteasome subunit beta-2i (PSB10_HUMAN)
  • Proteasome subunit beta type (Q6IB22_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P40306

UniProtKB/Swiss-Prot:

PSB10_HUMAN :
  • Belongs to the peptidase T1B family.
Family:
  • Belongs to the peptidase T1B family.
genes like me logo Genes that share domains with PSMB10: view

Function for PSMB10 Gene

Molecular function for PSMB10 Gene

UniProtKB/Swiss-Prot Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Cleavage of peptide bonds with very broad specificity.; EC=3.4.25.1;.
UniProtKB/Swiss-Prot Induction:
Up-regulated by IFNG/IFN-gamma (at protein level). Up-regulated by IRF1. Up-regulated by TNF (at protein level). Up-regulated by tetrodotoxin (TTX) in glial cells. Up-regulated in Crohn's bowel disease (CD). Up-regulated by CD40L via the NFKB1 pathway in cancer cells.
GENATLAS Biochemistry:
multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,beta-type subunit MECL-1,29kDa,interferon gamma inducible

Enzyme Numbers (IUBMB) for PSMB10 Gene

Phenotypes From GWAS Catalog for PSMB10 Gene

Gene Ontology (GO) - Molecular Function for PSMB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IBA,IEA 21873635
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 14733938
GO:0008233 peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PSMB10: view
genes like me logo Genes that share phenotypes with PSMB10: view

Animal Models for PSMB10 Gene

MGI Knock Outs for PSMB10:

Animal Model Products

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PSMB10 Gene

Localization for PSMB10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMB10 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMB10 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
endoplasmic reticulum 2
extracellular 1
cytoskeleton 1
mitochondrion 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PSMB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex TAS 9551082
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PSMB10: view

Pathways & Interactions for PSMB10 Gene

PathCards logo

SuperPathways for PSMB10 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 Chks in Checkpoint Regulation
.59
.59
.55
.43
.32
4 HIV Life Cycle
.45
5 Class I MHC mediated antigen processing and presentation
genes like me logo Genes that share pathways with PSMB10: view

Pathways by source for PSMB10 Gene

1 GeneGo (Thomson Reuters) pathway for PSMB10 Gene
  • Immune response Antigen presentation by MHC class I
12 Qiagen pathways for PSMB10 Gene
  • CDK5 Pathway
  • Chks in Checkpoint Regulation
  • DNA Repair Mechanisms
  • Estrogen-mediated S-Phase Entry
  • G2-M Phase Transition

Gene Ontology (GO) - Biological Process for PSMB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0000902 cell morphogenesis IEA --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002376 immune system process IEA --
genes like me logo Genes that share ontologies with PSMB10: view

No data available for SIGNOR curated interactions for PSMB10 Gene

Drugs & Compounds for PSMB10 Gene

(5) Drugs for PSMB10 Gene - From: DrugBank, ApexBio, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
carfilzomib Approved, Investigational Pharma Target, inhibitor, other Other, 20S Proteasome Inhibitor 0
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 888
Celastrol Pharma Antioxidant, anti-inflammatory and immunosuppressive agent 0
Dihydroeponemycin Pharma Proteasome inhibitor,antitumor reagent,eponemycin ddrivative 0
MLN2238 Pharma β5 site of the 20S proteasome inhibitor 0

(3) ApexBio Compounds for PSMB10 Gene

Compound Action Cas Number
Celastrol Antioxidant, anti-inflammatory and immunosuppressive agent 34157-83-0
Dihydroeponemycin Proteasome inhibitor,antitumor reagent,eponemycin ddrivative 126463-64-7
MLN2238 β5 site of the 20S proteasome inhibitor 1072833-77-2
genes like me logo Genes that share compounds with PSMB10: view

Drug Products

Transcripts for PSMB10 Gene

mRNA/cDNA for PSMB10 Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMB10 Gene

No ASD Table

Relevant External Links for PSMB10 Gene

GeneLoc Exon Structure for
PSMB10

Expression for PSMB10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PSMB10 Gene

mRNA differential expression in normal tissues according to GTEx for PSMB10 Gene

This gene is overexpressed in Whole Blood (x9.6).

Protein differential expression in normal tissues from HIPED for PSMB10 Gene

This gene is overexpressed in Lymph node (12.1), Peripheral blood mononuclear cells (8.2), and Tlymphocyte (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMB10 Gene



Protein tissue co-expression partners for PSMB10 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PSMB10

SOURCE GeneReport for Unigene cluster for PSMB10 Gene:

Hs.9661

Evidence on tissue expression from TISSUES for PSMB10 Gene

  • Intestine(4.4)
  • Liver(4.3)
  • Lung(3)
  • Spleen(2.8)
  • Blood(2.5)
  • Lymph node(2.5)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with PSMB10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMB10 Gene

Orthologs for PSMB10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PSMB10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMB10 31 30
  • 99.39 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PSMB10 31 30
  • 86.94 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PSMB10 31 30
  • 85.1 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Psmb10 17 31 30
  • 83.52 (n)
rat
(Rattus norvegicus)
Mammalia Psmb10 30
  • 82.54 (n)
oppossum
(Monodelphis domestica)
Mammalia PSMB10 31
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSMB10 31
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489016 30
  • 58.33 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:92791 30
  • 66.67 (n)
PSMB10 31
  • 62 (a)
OneToOne
Dr.15777 30
fruit fly
(Drosophila melanogaster)
Insecta CG18341 32
  • 49 (a)
Prosbeta2 31
  • 48 (a)
ManyToMany
Prosbeta2R1 31
  • 41 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea pbs-2 31
  • 36 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PUP1 31
  • 46 (a)
OneToMany
Species where no ortholog for PSMB10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSMB10 Gene

ENSEMBL:
Gene Tree for PSMB10 (if available)
TreeFam:
Gene Tree for PSMB10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PSMB10: view image

Paralogs for PSMB10 Gene