Aliases for PSMB10 Gene
Aliases for PSMB10 Gene
External Ids for PSMB10 Gene
- HGNC: 9538
- Entrez Gene: 5699
- Ensembl: ENSG00000205220
- OMIM: 176847
- UniProtKB: P40306
Previous HGNC Symbols for PSMB10 Gene
- MECL1
Previous GeneCards Identifiers for PSMB10 Gene
- GC16M058663
- GC16M068342
- GC16M067699
- GC16M067739
- GC16M066520
- GC16M066525
- GC16M067968
- GC16M053841
Summaries for PSMB10 Gene
-
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Proteolytic processing is required to generate a mature subunit. Expression of this gene is induced by gamma interferon, and this gene product replaces catalytic subunit 2 (proteasome beta 7 subunit) in the immunoproteasome. [provided by RefSeq, Jul 2008]
GeneCards Summary for PSMB10 Gene
PSMB10 (Proteasome Subunit Beta 10) is a Protein Coding gene. Among its related pathways are RET signaling and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include threonine-type endopeptidase activity. An important paralog of this gene is PSMB7.
UniProtKB/Swiss-Prot for PSMB10 Gene
-
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides.
Additional gene information for PSMB10 Gene
- Monarch Initiative
- Search for PSMB10 at DataMed
- Search for PSMB10 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMB10 Gene
Genomics for PSMB10 Gene
GeneHancer (GH) Regulatory Elements for PSMB10 Gene
Promoters and enhancers for PSMB10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PSMB10 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for PSMB10 Gene
Genomic Locations for PSMB10 Gene
- chr16:67,934,502-67,937,087
- (GRCh38/hg38)
- Size:
- 2,586 bases
- Orientation:
- Minus strand
- chr16:67,968,405-67,970,990
- (GRCh37/hg19)
Genomic View for PSMB10 Gene
Genes around PSMB10 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q22.1 by Ensembl
- 16q22.1 by Entrez Gene
- 16q22.1 by HGNC
PSMB10 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PSMB10 Gene
Proteins for PSMB10 Gene
-
Protein details for PSMB10 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P40306-PSB10_HUMAN
- Recommended name:
- Proteasome subunit beta type-10
- Protein Accession:
- P40306
- B2R5J4
- Q5U098
Protein attributes for PSMB10 Gene
- Size:
- 273 amino acids
- Molecular mass:
- 28936 Da
- Quaternary structure:
-
- The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Component of the immunoproteasome, where it displaces the equivalent houskeeping subunit PSMB7. Component of the spermatoproteasome, a form of the proteasome specifically found in testis. Interacts with HIV-1 TAT protein.
Protein Expression for PSMB10 Gene
Selected DME Specific Peptides for PSMB10 Gene
- P40306:
-
- LGADTRAT
- IYCCGAG
Post-translational modifications for PSMB10 Gene
- Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile proteolytic activity.
- Ubiquitination at isoforms=31, isoforms=37, isoforms=68, isoforms=72, Lys79, Lys101, and Lys236
- Modification sites at PhosphoSitePlus
Other Protein References for PSMB10 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for PSMB10 (PSMB10/MECL1)
-
Custom Antibody ServicesOriGene Antibodies for PSMB10
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-
Abcam antibodies for PSMB10
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- Search GeneTex for Antibodies for PSMB10
-
Santa Cruz Biotechnology (SCBT) Antibodies for PSMB10
Protein Products
-
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-
Abcam proteins for PSMB10
Assay Products
- antibodies-online: Search results for 1 available PSMB10 Elisa Kits ranked by validation data
- Compare Top PSMB10 Elisa Kits
-
Recommended
Domains & Families for PSMB10 Gene
Gene Families for PSMB10 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- FDA approved drug targets
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for PSMB10 Gene
Suggested Antigen Peptide Sequences for PSMB10 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P40306- Family:
-
- Belongs to the peptidase T1B family.
Function for PSMB10 Gene
Molecular function for PSMB10 Gene
- GENATLAS Biochemistry:
- multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,beta-type subunit MECL-1,29kDa,interferon gamma inducible
- UniProtKB/Swiss-Prot CatalyticActivity:
- Cleavage of peptide bonds with very broad specificity.
- UniProtKB/Swiss-Prot Function:
- The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated by IFNG/IFN-gamma (at protein level). Up-regulated by IRF1. Up-regulated by TNF (at protein level). Up-regulated by tetrodotoxin (TTX) in glial cells. Up-regulated in Crohns bowel disease (CD). Up-regulated by CD40L via the NFKB1 pathway in cancer cells.
Enzyme Numbers (IUBMB) for PSMB10 Gene
Phenotypes From GWAS Catalog for PSMB10 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004175 | endopeptidase activity | IEA | -- |
| GO:0004298 | threonine-type endopeptidase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 21516116 |
| GO:0008233 | peptidase activity | IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for PSMB10 Gene
- MGI mutant phenotypes for PSMB10:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PSMB10:
Animal Models for PSMB10 Gene
- MGI Knock Outs for PSMB10:
-
- Psmb10 tm1Mgro
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PSMB10
-
-
ViGene Biosciences lentiviral particle packaged cDNA for PSMB10 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PSMB10 gene
- Search ViGene Biosciences for PSMB10
CRISPR Products
-
OriGene CRISPR knockouts for PSMB10
- genomics-online: gRNA clones - Search results for 99 available PSMB10 gene related products
- Overview of 99 available PSMB10 gene related products
- Applied Biological Materials CRISPR for PSMB10
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSMB10
- GenScript: Design CRISPR guide RNA sequences for PSMB10
miRNA Products
- Search ViGene Biosciences for PSMB10
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PSMB10
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- genomics-online: shRNA clones - Search results for 99 available PSMB10 gene related products
- Overview of 99 available PSMB10 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PSMB10 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for PSMB10
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for PSMB10
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PSMB10
-
ViGene Biosciences adenoviral particle packaged cDNA for PSMB10 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PSMB10 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PSMB10 gene
No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PSMB10 Gene
Localization for PSMB10 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PSMB10 Gene
- Cytoplasm. Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| endoplasmic reticulum | 1 |
- Cytosol (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000502 | proteasome complex | TAS | 9551082 |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for PSMB10 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | CDK-mediated phosphorylation and removal of Cdc6 |
.93
.93
|
.80
.78
.78
.70
.47
.31
|
| 2 | RET signaling |
.92
|
.92
|
| 3 | Chks in Checkpoint Regulation | ||
| 4 | HIV Life Cycle |
.65
|
.45
|
| 5 | Class I MHC mediated antigen processing and presentation | ||
Pathways by source for PSMB10 Gene
1 BioSystems pathway for PSMB10 Gene
164 Reactome pathways for PSMB10 Gene
1 KEGG pathway for PSMB10 Gene
1 GeneGo (Thomson Reuters) pathway for PSMB10 Gene
12 Qiagen pathways for PSMB10 Gene
Interacting Proteins for PSMB10 Gene
Selected Interacting proteins:
ENSP00000351314
P40306-PSB10_HUMAN
for PSMB10 Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
No data available for SIGNOR curated interactions for PSMB10 Gene
Drugs & Compounds for PSMB10 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| carfilzomib | Approved, Investigational | Pharma | Target, inhibitor, other | Other, 20S Proteasome Inhibitor | 0 | |
| Bortezomib | Approved, Investigational | Pharma | inhibitor, other | Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors | 826 | |
| Kyprolis | Approved July 2012 | Pharma | 0 | |||
| Celastrol | Pharma | Antioxidant, anti-inflammatory and immunosuppressive agent | 0 | |||
| Dihydroeponemycin | Pharma | Proteasome inhibitor,antitumor reagent,eponemycin ddrivative | 0 |
(3) ApexBio Compounds for PSMB10 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Celastrol | Antioxidant, anti-inflammatory and immunosuppressive agent | 34157-83-0 |
| Dihydroeponemycin | Proteasome inhibitor,antitumor reagent,eponemycin ddrivative | 126463-64-7 |
| MLN2238 | β5 site of the 20S proteasome inhibitor | 1072833-77-2 |
Transcripts for PSMB10 Gene
mRNA/cDNA for PSMB10 Gene
- (1) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (282) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PSMB10 Gene
CRISPR Products
-
OriGene CRISPR knockouts for PSMB10
- genomics-online: gRNA clones - Search results for 99 available PSMB10 gene related products
- Overview of 99 available PSMB10 gene related products
- Applied Biological Materials CRISPR for PSMB10
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSMB10
- GenScript: Design CRISPR guide RNA sequences for PSMB10
miRNA Products
- Search ViGene Biosciences for PSMB10
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PSMB10
- Browse OriGene Inhibitory RNA Products For PSMB10
- genomics-online: shRNA clones - Search results for 99 available PSMB10 gene related products
- Overview of 99 available PSMB10 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PSMB10 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for PSMB10
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PSMB10
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for PSMB10
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for PSMB10 Gene
mRNA differential expression in normal tissues according to GTEx for PSMB10 Gene
This gene is overexpressed in Whole Blood (x9.6).
This gene is overexpressed in Lymph node (12.1), Peripheral blood mononuclear cells (8.2), and Tlymphocyte (6.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSMB10 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of PSMB10 Gene:
PSMB10SOURCE GeneReport for Unigene cluster for PSMB10 Gene:
Hs.9661Evidence on tissue expression from TISSUES for PSMB10 Gene
- Intestine(4.3)
- Liver(4.3)
- Lung(2.8)
- Spleen(2.8)
- Blood(2.5)
- Lymph node(2.5)
- Nervous system(2)
Primer Products
-
OriGene qPCR primer pairs for PSMB10
-
OriGene qPCR primer pairs and template standards for PSMB10
- genomics-online: primer clones - Search results for 99 available PSMB10 gene related products
- Overview of 99 available PSMB10 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMB10 Gene
Orthologs for PSMB10 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PSMB10 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | PSMB10 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | PSMB10 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Psmb10 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Psmb10 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PSMB10 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PSMB10 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100489016 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | zgc:92791 33 |
|
||
| PSMB10 34 |
|
OneToOne | |||
| Dr.15777 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CG18341 35 |
|
|
|
| Prosbeta2 34 |
|
ManyToMany | |||
| Prosbeta2R1 34 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | pbs-2 34 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PUP1 34 |
|
OneToMany |
- Species where no ortholog for PSMB10 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for PSMB10 Gene
Paralogs for PSMB10 Gene
(3) SIMAP similar genes for PSMB10 Gene using alignment to 3 proteins:
Variants for PSMB10 Gene
| SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1001085577 | -- | 67,935,995(-) | C/T | coding_sequence_variant, synonymous_variant | |
| rs1001271194 | -- | 67,935,771(-) | C/A | intron_variant | |
| rs1001769119 | -- | 67,936,207(-) | A/C | intron_variant | |
| rs1003119222 | -- | 67,937,766(-) | C/G | upstream_transcript_variant | |
| rs1003665921 | -- | 67,938,318(-) | T/C | upstream_transcript_variant |
Residual Variation Intolerance Score:
39.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.13;
22.91% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PSMB10 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PSMB10
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMB10 Gene
Disorders for PSMB10 Gene
Additional Disease Information for PSMB10
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for PSMB10 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMB10 Gene
Publications for PSMB10 Gene
- CD40 induces antigen transporter and immunoproteasome gene expression in carcinomas via the coordinated action of NF-kappaB and of NF-kappaB-mediated de novo synthesis of IRF-1. (PMID: 18694960) Moschonas A … Eliopoulos AG (Molecular and cellular biology 2008) 3 4 22 58
- Constitutive and interferon-gamma-induced expression of the human proteasome subunit multicatalytic endopeptidase complex-like 1. (PMID: 9551082) Foss GS … Prydz H (Biochimica et biophysica acta 1998) 3 4 22 58
- A tight cluster of five unrelated human genes on chromosome 16q22.1. (PMID: 8268911) Larsen F … Prydz H (Human molecular genetics 1993) 2 3 4 58
- A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PMID: 22412388) Kenny EE … Peter I (PLoS genetics 2012) 3 44 58
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
Products for PSMB10 Gene
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- VectorBuilder custom plasmid, inducible vectors for PSMB10
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 63 available PSMB10 Antibodies ranked by validation data
- Compare Top PSMB10 Antibodies
- antibodies-online: Search results for 1 available PSMB10 Elisa Kits ranked by validation data
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- Recommended
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