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The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Proteolytic processing is required to generate a mature subunit. Expression of this gene is induced by gamma interferon, and this gene product replaces catalytic subunit 2 (proteasome beta 7 subunit) in the immunoproteasome. [provided by RefSeq, Jul 2008]
PSMB10 (Proteasome 20S Subunit Beta 10) is a Protein Coding gene. Diseases associated with PSMB10 include Proteasome-Associated Autoinflammatory Syndrome 5 and Immunodeficiency 12. Among its related pathways are Downstream signaling events of B Cell Receptor (BCR) and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include threonine-type endopeptidase activity. An important paralog of this gene is PSMB7.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004175 | endopeptidase activity | IEA,IBA | 21873635 |
GO:0004298 | threonine-type endopeptidase activity | IEA | -- |
GO:0005515 | protein binding | IPI | 14733938 |
GO:0008233 | peptidase activity | IEA | -- |
GO:0016787 | hydrolase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000502 | proteasome complex | TAS | 9551082 |
GO:0005634 | nucleus | IEA,IBA | 21873635 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | CDK-mediated phosphorylation and removal of Cdc6 |
.93
.93
|
.80
.80
.78
.70
.47
.31
|
2 | RET signaling |
.92
|
.92
|
3 | Chks in Checkpoint Regulation |
Chks in Checkpoint Regulation
.59
G2-M Phase Transition
.59
Estrogen-mediated S-Phase Entry
.55
|
SREBP Proteolysis
.43
DNA Repair Mechanisms
.32
|
4 | HIV Life Cycle |
.64
|
.45
|
5 | Class I MHC mediated antigen processing and presentation |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000165 | MAPK cascade | TAS | -- |
GO:0000209 | protein polyubiquitination | TAS | -- |
GO:0000902 | cell morphogenesis | IEA | -- |
GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
GO:0002376 | immune system process | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
carfilzomib | Approved, Investigational | Pharma | Target, inhibitor, other | Other, 20S Proteasome Inhibitor | 0 | |
Bortezomib | Approved, Investigational | Pharma | inhibitor, other | Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors | 926 | |
Celastrol | Pharma | Antioxidant, anti-inflammatory and immunosuppressive agent | 0 | |||
Dihydroeponemycin | Pharma | Proteasome inhibitor,antitumor reagent,eponemycin ddrivative | 0 | |||
MLN2238 | Pharma | β5 site of the 20S proteasome inhibitor | 0 |
Compound | Action | Cas Number |
---|---|---|
Celastrol | Antioxidant, anti-inflammatory and immunosuppressive agent | 34157-83-0 |
Dihydroeponemycin | Proteasome inhibitor,antitumor reagent,eponemycin ddrivative | 126463-64-7 |
MLN2238 | β5 site of the 20S proteasome inhibitor | 1072833-77-2 |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PSMB10 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PSMB10 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PSMB10 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Psmb10 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Psmb10 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | PSMB10 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | PSMB10 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100489016 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | zgc:92791 30 |
|
||
PSMB10 31 |
|
OneToOne | |||
Dr.15777 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG18341 32 |
|
|
|
Prosbeta2 31 |
|
ManyToMany | |||
Prosbeta2R1 31 |
|
ManyToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | pbs-2 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PUP1 31 |
|
OneToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
proteasome-associated autoinflammatory syndrome 5 |
|
|
immunodeficiency 12 |
|
|