Aliases for PSMA8 Gene
External Ids for PSMA8 Gene
Previous GeneCards Identifiers for PSMA8 Gene
GeneCards Summary for PSMA8 Gene
PSMA8 (Proteasome 20S Subunit Alpha 8) is a Protein Coding gene. Diseases associated with PSMA8 include Pelvic Varices and Cystic Fibrosis. Among its related pathways are Regulation of degradation of deltaF508 CFTR in CF and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include endopeptidase activity and threonine-type endopeptidase activity. An important paralog of this gene is PSMA7.
UniProtKB/Swiss-Prot Summary for PSMA8 Gene
Component of the spermatoproteasome, a form of the proteasome specifically found in testis that promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH (By similarity).