Aliases for PSMA8 Gene
External Ids for PSMA8 Gene
Previous GeneCards Identifiers for PSMA8 Gene
GeneCards Summary for PSMA8 Gene
PSMA8 (Proteasome 20S Subunit Alpha 8) is a Protein Coding gene. Diseases associated with PSMA8 include Cystic Fibrosis and Pelvic Varices. Among its related pathways are Downstream signaling events of B Cell Receptor (BCR) and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include endopeptidase activity and threonine-type endopeptidase activity. An important paralog of this gene is PSMA7.
UniProtKB/Swiss-Prot Summary for PSMA8 Gene
Component of the spermatoproteasome, a proteasome specifically found in testis that promotes acetylation-dependent degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a protein complexe that degrades unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Required for 20S core proteasome assembly, essential for the degradation of meiotic proteins RAD51 and RPA1 at late prophase I and the progression of meiosis I during spermatogenesis. Localizes to the synaptonemal complex, a 'zipper'-like structure that holds homologous chromosome pairs in synapsis during meiotic prophase I.