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PSMA8 (Proteasome 20S Subunit Alpha 8) is a Protein Coding gene. Diseases associated with PSMA8 include Cystic Fibrosis and Pelvic Varices. Among its related pathways are Downstream signaling events of B Cell Receptor (BCR) and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include endopeptidase activity and threonine-type endopeptidase activity. An important paralog of this gene is PSMA7.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH18J026133 | Promoter/Enhancer | 1.1 | EPDnew Ensembl ENCODE | 250.7 | +0.2 | 187 | 1.5 | POLR2A YY1 TAF1 ZBTB33 EGR1 GABPB1 | HSALNG0120561 PSMA8 piR-57460-303 SS18 TAF4B | |
GH18J026167 | Enhancer | 0.7 | Ensembl | 0.3 | +33.8 | 33837 | 0.3 | NR2C1 TRIM22 BHLHE40 ELF1 IKZF1 BMI1 NR2F1 TCF12 ZNF217 ARID3A | HSALNG0120562 lnc-SS18-8 piR-57460-303 PSMA8 TAF4B | |
GH18J026168 | Enhancer | 0.5 | Ensembl | 0.3 | +34.6 | 34649 | 1 | TRIM22 NR2F1 ATF7 IKZF2 NBN DPF2 RELB ZBTB40 ARNT | HSALNG0120562 DHFRP1 lnc-SS18-8 PSMA8 TAF4B | |
GH18J026190 | Enhancer | 0.7 | ENCODE | 0.2 | +57.4 | 57353 | 1.7 | BHLHE40 ASH2L MCM5 ZNF24 IKZF1 TCF7 NR2F1 HDGF ATF2 TCF12 | SS18 piR-57460-304 DHFRP1 TAF4B PSMA8 | |
GH18J026214 | Enhancer | 0.9 | FANTOM5 ENCODE | 0.2 | +81.4 | 81433 | 1.8 | ZNF316 SPI1 ELF1 SCRT1 MAFG TCF7 MAFK ARID3A IKZF1 ATF7 | SS18 piR-43105-291 TAF4B PSMA8 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004175 | endopeptidase activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000502 | proteasome complex | IEA | -- |
GO:0005634 | nucleus | IEA,ISS | -- |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005829 | cytosol | TAS | -- |
GO:0005839 | proteasome core complex | IEA,IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | CDK-mediated phosphorylation and removal of Cdc6 |
.93
.93
|
.80
.80
.78
.70
.47
.31
|
2 | RET signaling |
.92
|
.92
|
3 | HIV Life Cycle |
.64
|
.45
|
4 | Pathways of neurodegeneration - multiple diseases | ||
5 | Class I MHC mediated antigen processing and presentation |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000165 | MAPK cascade | TAS | -- |
GO:0000209 | protein polyubiquitination | TAS | -- |
GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
GO:0006511 | ubiquitin-dependent protein catabolic process | IEA | -- |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||
SP2: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PSMA8 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | PSMA8 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PSMA8 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PSMA8 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Psma8 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Psma8 30 17 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | psma8 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005423 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Pros28.1 30 31 |
|
ManyToMany | |
Pros28.1A 31 |
|
ManyToMany | |||
Pros28.1B 31 |
|
ManyToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | pas-4 31 |
|
OneToMany | |
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0B11836g 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PRE6 30 31 |
|
OneToMany | |
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AAR012C 30 |
|
||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | PAD1 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os09g0538200 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.4812 31 |
|
OneToMany | |
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | pre6 30 |
|
||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU06440 30 |
|
||
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.3518 30 |
|
Disorder | Aliases | PubMed IDs |
---|---|---|
cystic fibrosis |
|
|
pelvic varices |
|
|