Aliases for PSMA7 Gene
Aliases for PSMA7 Gene
External Ids for PSMA7 Gene
- HGNC: 9536
- Entrez Gene: 5688
- Ensembl: ENSG00000101182
- OMIM: 606607
- UniProtKB: O14818
Previous GeneCards Identifiers for PSMA7 Gene
- GC20M060475
- GC20M061350
- GC20M061397
- GC20M060145
- GC20M060711
- GC20M057489
Summaries for PSMA7 Gene
-
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the peptidase T1A family that functions as a 20S core alpha subunit. The encoded protein interacts with the hepatitis B virus X protein and plays a role in regulating hepatitis C virus internal ribosome entry site (IRES) activity, an activity essential for viral replication. The encoded protein also plays a role in the cellular stress response by regulating hypoxia-inducible factor-1alpha. A pseudogene of this gene is located on the long arm of chromosome 9. [provided by RefSeq, Jul 2012]
GeneCards Summary for PSMA7 Gene
PSMA7 (Proteasome Subunit Alpha 7) is a Protein Coding gene. Diseases associated with PSMA7 include Hypoxia and Hepatitis C Virus. Among its related pathways are RET signaling and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include identical protein binding and threonine-type endopeptidase activity. An important paralog of this gene is PSMA8.
UniProtKB/Swiss-Prot for PSMA7 Gene
-
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMA7 Gene
Genomics for PSMA7 Gene
GeneHancer (GH) Regulatory Elements for PSMA7 Gene
Promoters and enhancers for PSMA7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PSMA7 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PSMA7 gene promoter:
Regulatory Element Products
Genomic Locations for PSMA7 Gene
Genomic Locations for PSMA7 Gene
- chr20:62,136,727-62,143,458
- (GRCh38/hg38)
- Size:
- 6,732 bases
- Orientation:
- Minus strand
- chr20:60,711,791-60,718,496
- (GRCh37/hg19)
Genomic View for PSMA7 Gene
Genes around PSMA7 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q13.33 by Ensembl
- 20q13.33 by Entrez Gene
- 20q13.33 by HGNC
PSMA7 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PSMA7 Gene
Proteins for PSMA7 Gene
-
Protein details for PSMA7 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O14818-PSA7_HUMAN
- Recommended name:
- Proteasome subunit alpha type-7
- Protein Accession:
- O14818
- B2R515
- Q5JXJ2
- Q9BR53
- Q9H4K5
- Q9UEU8
Protein attributes for PSMA7 Gene
- Size:
- 248 amino acids
- Molecular mass:
- 27887 Da
- Quaternary structure:
-
- The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. PSMA7 interacts directly with the PSMG1-PSMG2 heterodimer which promotes 20S proteasome assembly (PubMed:16251969). Interacts with HIV-1 TAT protein (PubMed:14550573). Interacts with hepatitis B virus X protein (HBX) (PubMed:8764072). Interacts with HIF1A. Interacts with RAB7A (PubMed:14998988). Interacts with PRKN (PubMed:15987638). Interacts with ABL1 and ABL2 (PubMed:16678104). Interacts with EMAP2 (PubMed:19362550). Interacts with MAVS (PubMed:19734229).
Three dimensional structures from OCA and Proteopedia for PSMA7 Gene
Protein Expression for PSMA7 Gene
Selected DME Specific Peptides for PSMA7 Gene
- O14818:
-
- RTVRKIC
- EKKKQKK
- VVLGVEK
- EFLEKNY
- YDRAITVFSPDG
- LYQTDPSG
- RARVECQ
- IKALLEVVQSGGKNIELA
- YTQSNGRRPFG
- EIEKEKEE
- LFQVEYA
- EAVKKGSTA
- EYITRYIA
- GLTADAR
- LTVEDPVTVEYITR
Post-translational modifications for PSMA7 Gene
- Phosphorylation by ABL1 or ABL2 leads to an inhibition of proteasomal activity and cell cycle transition blocks.
- Ubiquitination at Lys61, isoforms=2115, Lys174, Lys204, Lys218, and Lys227
- Glycosylation at isoforms=2130
Other Protein References for PSMA7 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for PSMA7
-
Abcam antibodies for PSMA7
-
Cloud-Clone Corp. Antibodies for PSMA7
- Invitrogen Antibodies for PSMA7
- GeneTex PSMA7 antibody for PSMA7
-
Santa Cruz Biotechnology (SCBT) Antibodies for PSMA7
Protein Products
-
OriGene Purified Proteins for PSMA7
- Search Origene for MassSpec and Protein Over-expression Lysates for PSMA7
- Origene Custom Protein Services for PSMA7
- ProSpec Recombinant Proteins for PSMA7
-
Cloud-Clone Corp. Proteins for PSMA7
- Search GeneTex for Proteins for PSMA7
-
Abcam proteins for PSMA7
Assay Products
-
Cloud-Clone Corp. Assay Kits for PSMA7
- antibodies-online: Search results for 5 available PSMA7 Elisa Kits ranked by validation data
- Compare Top PSMA7 Elisa Kits
-
Recommended
Domains & Families for PSMA7 Gene
Gene Families for PSMA7 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for PSMA7 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PSMA7 Gene
Graphical View of Domain Structure for InterPro Entry
O14818- Family:
-
- Belongs to the peptidase T1A family.
Function for PSMA7 Gene
Molecular function for PSMA7 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- Cleavage of peptide bonds with very broad specificity.
- UniProtKB/Swiss-Prot Function:
- Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response.
- UniProtKB/Swiss-Prot Induction:
- Down-regulated by the ribozyme Rz3X. Up-regulated in colorectal cancer tissues.
Enzyme Numbers (IUBMB) for PSMA7 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004175 | endopeptidase activity | IEA | -- |
| GO:0004298 | threonine-type endopeptidase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 12376572 |
| GO:0008233 | peptidase activity | IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for PSMA7 Gene
- GenomeRNAi human phenotypes for PSMA7:
-
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased viability
- shRNA abundance <= 50%
- Synthetic lethal with Ras
- FOXO1 nuclear localization
- Decreased viability with paclitaxel
- Increased G1 DNA content
- G0/1 arrest
- Decreased shRNA abundance (Z-score < -2)
- Decreased homologous recombination repair frequency
- Decreased shRNA abundance
- Increased shRNA abundance (Z-score > 2)
- Negative genetic interaction between BLM-/- and BLM+/+
- Increased Sindbis virus (SINV) infection
- Decreased HIV-1 infection
- Downregulation of NFkappaB pathway
- HIV Rev nuclear localization
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PSMA7
-
-
ViGene Biosciences lentiviral particle packaged cDNA for PSMA7 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PSMA7 gene
- Search ViGene Biosciences for PSMA7
CRISPR Products
-
OriGene CRISPR knockouts for PSMA7
- genomics-online: gRNA clones - Search results for available PSMA7 gene related products
- Applied Biological Materials CRISPR for PSMA7
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSMA7
miRNA for PSMA7 Gene
- miRTarBase miRNAs that target PSMA7
-
- hsa-mir-92b-3p (MIRT040706)
- hsa-mir-193b-3p (MIRT041274)
- hsa-mir-92a-3p (MIRT049617)
- hsa-mir-3978 (MIRT456014)
- hsa-mir-466 (MIRT456015)
- hsa-mir-1257 (MIRT456016)
- hsa-mir-613 (MIRT456017)
- hsa-mir-206 (MIRT456018)
- hsa-mir-1-3p (MIRT456019)
- hsa-mir-4302 (MIRT456020)
- hsa-mir-6733-3p (MIRT456021)
- hsa-mir-3688-3p (MIRT456022)
- hsa-mir-4643 (MIRT456023)
- hsa-mir-4789-3p (MIRT456024)
- hsa-mir-522-3p (MIRT456025)
- hsa-mir-224-3p (MIRT456026)
- hsa-mir-4694-3p (MIRT456027)
- hsa-mir-6768-3p (MIRT456028)
- hsa-mir-1197 (MIRT761214)
miRNA Products
- Search ViGene Biosciences for PSMA7
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PSMA7
- Browse OriGene Inhibitory RNA Products For PSMA7
- genomics-online: shRNA clones - Search results for available PSMA7 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PSMA7 gene
Clone Products
- Sino Biological Human cDNA Clone for PSMA7
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PSMA7
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PSMA7
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available PSMA7 gene related products
- orf clones - Search results for available PSMA7 gene related products
- Applied Biological Materials Clones for PSMA7
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for PSMA7 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PSMA7 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PSMA7 gene
No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMA7 Gene
Localization for PSMA7 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PSMA7 Gene
- Cytoplasm. Nucleus.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 2 |
| mitochondrion | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000502 | proteasome complex | TAS,IDA | 17323924 |
| GO:0005634 | nucleus | IEA,HDA | 21630459 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PSMA7 Gene
Pathways & Interactions for PSMA7 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | CDK-mediated phosphorylation and removal of Cdc6 |
.93
.93
|
.80
.78
.78
.70
.47
.31
|
| 2 | RET signaling |
.92
|
.92
|
| 3 | Chks in Checkpoint Regulation | ||
| 4 | HIV Life Cycle |
.65
|
.45
|
| 5 | Class I MHC mediated antigen processing and presentation | ||
Pathways by source for PSMA7 Gene
1 Sino Biological pathway for PSMA7 Gene
1 BioSystems pathway for PSMA7 Gene
1 KEGG pathway for PSMA7 Gene
4 GeneGo (Thomson Reuters) pathways for PSMA7 Gene
18 Qiagen pathways for PSMA7 Gene
Interacting Proteins for PSMA7 Gene
Selected Interacting proteins:
ENSP00000359910
O14818-PSA7_HUMAN
for PSMA7 Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
| GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
| GO:0006508 | proteolysis | IEA | -- |
Drugs & Compounds for PSMA7 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Bortezomib | Approved, Investigational | Pharma | inhibitor, other | Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors | 826 | |
| carfilzomib | Approved, Investigational | Pharma | other, Inhibitor | Other, 20S Proteasome Inhibitor | 0 | |
| (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE | Experimental | Pharma | Target | 0 | ||
| 2-ACETYLAMINO-4-METHYL-PENTANOIC ACID [1-(1-FORMYL-PENTYLCARBAMOYL)-3-METHYL-BUTYL]-AMIDE | Experimental | Pharma | Target | 0 |
Transcripts for PSMA7 Gene
mRNA/cDNA for PSMA7 Gene
- (2) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (760) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PSMA7 Gene
CRISPR Products
-
OriGene CRISPR knockouts for PSMA7
- genomics-online: gRNA clones - Search results for available PSMA7 gene related products
- Applied Biological Materials CRISPR for PSMA7
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSMA7
miRNA Products
- Search ViGene Biosciences for PSMA7
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PSMA7
- Browse OriGene Inhibitory RNA Products For PSMA7
- genomics-online: shRNA clones - Search results for available PSMA7 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PSMA7 gene
Clone Products
- Sino Biological Human cDNA Clone for PSMA7
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PSMA7
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PSMA7
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available PSMA7 gene related products
- orf clones - Search results for available PSMA7 gene related products
- Applied Biological Materials Clones for PSMA7
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP9: | - |
Expression for PSMA7 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for PSMA7 Gene
This gene is overexpressed in Muscle - Skeletal (x4.1).
This gene is overexpressed in Liver, secretome (11.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSMA7 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of PSMA7 Gene:
PSMA7SOURCE GeneReport for Unigene cluster for PSMA7 Gene:
Hs.233952Evidence on tissue expression from TISSUES for PSMA7 Gene
- Liver(4.8)
- Nervous system(4.8)
- Blood(4.7)
- Lung(4.7)
- Bone marrow(3.7)
- Skin(3.2)
- Eye(2.9)
- Spleen(2.8)
- Heart(2.7)
- Muscle(2.4)
- Bone(2.3)
- Lymph node(2.3)
- Pancreas(2)
Primer Products
-
OriGene qPCR primer pairs for PSMA7
-
OriGene qPCR primer pairs and template standards for PSMA7
- genomics-online: primer clones - Search results for available PSMA7 gene related products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMA7 Gene
Orthologs for PSMA7 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PSMA7 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | PSMA7 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | PSMA7 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | PSMA7 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Psma7 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Psma7 33 16 34 |
|
||
| chicken (Gallus gallus) |
Aves | PSMA7 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | PSMA7 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | psma7 33 |
|
||
| MGC75728 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.2813 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Pros28.1 35 34 |
|
||
| Pros28.1A 35 34 |
|
||||
| Pros28.1B 35 34 |
|
||||
| worm (Caenorhabditis elegans) |
Secernentea | pas-4 33 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PRE6 34 36 |
|
OneToMany | |
| soybean (Glycine max) |
eudicotyledons | Gma.2587 33 |
|
||
| barley (Hordeum vulgare) |
Liliopsida | Hv.3003 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.4812 34 |
|
OneToMany |
- Species where no ortholog for PSMA7 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- zebrafish (Danio rerio)
Paralogs for PSMA7 Gene
(8) SIMAP similar genes for PSMA7 Gene using alignment to 3 proteins:
Pseudogenes.org Pseudogenes for PSMA7 Gene
Variants for PSMA7 Gene
| SNP ID | Clin | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000110014 | -- | 62,136,464(-) | T/C | downstream_transcript_variant | |
| rs1000119810 | -- | 62,136,285(-) | A/C | downstream_transcript_variant | |
| rs1000308221 | -- | 62,140,065(-) | T/A | intron_variant | |
| rs1000643887 | -- | 62,141,343(-) | G/A/C | intron_variant | |
| rs1000945494 | -- | 62,141,671(-) | C/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv586481 | CNV | gain | 21841781 |
| nsv586476 | CNV | gain | 21841781 |
| nsv586475 | CNV | loss | 21841781 |
| nsv509782 | CNV | insertion | 20534489 |
| nsv3440 | CNV | insertion | 18451855 |
| nsv1143990 | CNV | deletion | 24896259 |
| nsv1112793 | CNV | deletion | 24896259 |
| esv22512 | CNV | loss | 19812545 |
| esv1006840 | CNV | deletion | 20482838 |
| dgv7648n54 | CNV | gain+loss | 21841781 |
Residual Variation Intolerance Score:
34.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.22;
4.86% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PSMA7 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMA7 Gene
Disorders for PSMA7 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hypoxia |
|
|
| hepatitis c virus |
|
|
| hepatitis |
|
|
| hepatitis b |
|
|
| leukemia, acute myeloid |
|
|
Search PSMA7 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PSMA7
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for PSMA7 Gene
Publications for PSMA7 Gene
- Binding and regulation of HIF-1alpha by a subunit of the proteasome complex, PSMA7. (PMID: 11389899) Cho S … Ryu SE (FEBS letters 2001) 3 4 22 58
- Proteasome complex as a potential cellular target of hepatitis B virus X protein. (PMID: 8764072) Huang J … Liang TJ (Journal of virology 1996) 2 3 4 58
- Crystal structure of the human 20S proteasome in complex with carfilzomib. (PMID: 25599644) Harshbarger W … Sacchettini J (Structure (London, England : 1993) 2015) 3 4 58
- Negative regulation of MAVS-mediated innate immune response by PSMA7. (PMID: 19734229) Jia Y … Zhong H (Journal of immunology (Baltimore, Md. : 1950) 2009) 3 4 58
- PSMA7, a potential biomarker of diseases. (PMID: 19442227) Du H … Li M (Protein and peptide letters 2009) 3 4 58
Products for PSMA7 Gene
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- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for PSMA7
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 74 available PSMA7 Antibodies ranked by validation data
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- GeneTex PSMA7 antibody for PSMA7
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- ViGene Biosciences adenoviral particle packaged cDNA for PSMA7 gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for PSMA7
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- genomics-online: cdna clones - Search results for available PSMA7 gene related products
- orf clones - Search results for available PSMA7 gene related products
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- genomics-online: primer clones - Search results for available PSMA7 gene related products
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Sources for PSMA7 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
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- (11) GO
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- (14) ProtoNet
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- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
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- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
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- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
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- (114) diseasecard
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- (138)