PSMA7 Gene (Protein Coding)

Proteasome 20S Subunit Alpha 7

GC20M062136
GIFtS:
46
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration a... See more...

Aliases for PSMA7 Gene

Aliases for PSMA7 Gene

  • Proteasome 20S Subunit Alpha 7 2 3 5
  • Proteasome Subunit XAPC7 2 3 4
  • Proteasome Subunit RC6-1 2 3 4
  • HSPC 2 3 4
  • Proteasome (Prosome, Macropain) Subunit, Alpha Type, 7 2 3
  • Proteasome Subunit Alpha Type-7 3 4
  • Proteasome Subunit Alpha 7 2 3
  • RC6-1 2 3
  • XAPC7 2 3
  • C6 2 3
  • Epididymis Secretory Protein Li 276 3
  • Testicular Tissue Protein Li 151 3
  • Proteasome Subunit Alpha 4 3
  • Proteasome Subunit Α4 2
  • EC 3.4.25.1 51
  • HEL-S-276 3
  • PSMA7 5

External Ids for PSMA7 Gene

Previous GeneCards Identifiers for PSMA7 Gene

  • GC20M060475
  • GC20M061350
  • GC20M061397
  • GC20M060145
  • GC20M060711
  • GC20M057489

Summaries for PSMA7 Gene

Entrez Gene Summary for PSMA7 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the peptidase T1A family that functions as a 20S core alpha subunit. The encoded protein interacts with the hepatitis B virus X protein and plays a role in regulating hepatitis C virus internal ribosome entry site (IRES) activity, an activity essential for viral replication. The encoded protein also plays a role in the cellular stress response by regulating hypoxia-inducible factor-1alpha. A pseudogene of this gene is located on the long arm of chromosome 9. [provided by RefSeq, Jul 2012]

GeneCards Summary for PSMA7 Gene

PSMA7 (Proteasome 20S Subunit Alpha 7) is a Protein Coding gene. Diseases associated with PSMA7 include Hypoxia and Hepatitis. Among its related pathways are Downstream signaling events of B Cell Receptor (BCR) and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include identical protein binding and threonine-type endopeptidase activity. An important paralog of this gene is PSMA8.

UniProtKB/Swiss-Prot Summary for PSMA7 Gene

  • Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response.

Gene Wiki entry for PSMA7 Gene

Additional gene information for PSMA7 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSMA7 Gene

Genomics for PSMA7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for PSMA7 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH20J062140 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 -0.4 -417 6.2 TBP SP1 ZBTB10 MXD4 MNT IKZF1 SMAD5 HES1 ZFP64 CTCF SS18L1 PSMA7 DIDO1 LAMA5 TAF4 ENSG00000226332 MTG2 piR-49264 HSALNG0131485
GH20J062041 Enhancer 1.1 Ensembl ENCODE 11.2 +100.5 100479 2.4 MXD4 CEBPA ZIC2 HOMEZ THAP11 CEBPB ZNF511 SMAD4 SAP130 RXRA TAF4 LSM14B PSMA7 SS18L1 CDH4 piR-35674-317 lnc-PSMA7-3
GH20J062018 Enhancer 0.8 Ensembl ENCODE 12.3 +122.3 122339 4.6 ZIC2 MAFF RXRA RBM22 HNF4A NRF1 ZBTB33 IKZF1 REST MAFK PSMA7 SS18L1 CDH4 lnc-PSMA7-5 lnc-PSMA7-4 TAF4
GH20J062010 Enhancer 0.8 ENCODE 12.1 +132.4 132410 0.2 MNT CTCF BHLHE40 SIN3A REST VEZF1 TRIM22 SAP130 SMC3 GABPB1 lnc-PSMA7-5 PSMA7 SS18L1 HRH3 CDH4 lnc-PSMA7-4 TAF4
GH20J062003 Enhancer 0.7 ENCODE 11.8 +140.2 140220 0.2 HOMEZ THAP11 SMAD4 MAFF RXRA ZSCAN9 RARA FOXA2 DMAP1 RBM22 LOC105372704 PSMA7 SS18L1 MIR1257 lnc-PSMA7-6 TAF4 CDH4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSMA7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PSMA7

Top Transcription factor binding sites by QIAGEN in the PSMA7 gene promoter:
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • AP-2alphaA

Genomic Locations for PSMA7 Gene

Latest Assembly
chr20:62,136,733-62,143,440
(GRCh38/hg38)
Size:
6,708 bases
Orientation:
Minus strand

Previous Assembly
chr20:60,711,789-60,718,450
(GRCh37/hg19 by Entrez Gene)
Size:
6,662 bases
Orientation:
Minus strand

chr20:60,711,791-60,718,496
(GRCh37/hg19 by Ensembl)
Size:
6,706 bases
Orientation:
Minus strand

Genomic View for PSMA7 Gene

Genes around PSMA7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMA7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMA7 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PSMA7 Gene

Proteins for PSMA7 Gene

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  • Protein details for PSMA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14818-PSA7_HUMAN
    Recommended name:
    Proteasome subunit alpha type-7
    Protein Accession:
    O14818
    Secondary Accessions:
    • B2R515
    • Q5JXJ2
    • Q9BR53
    • Q9H4K5
    • Q9UEU8

    Protein attributes for PSMA7 Gene

    Size:
    248 amino acids
    Molecular mass:
    27887 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. PSMA7 interacts directly with the PSMG1-PSMG2 heterodimer which promotes 20S proteasome assembly (PubMed:16251969). Interacts with HIF1A. Interacts with RAB7A (PubMed:14998988). Interacts with PRKN (PubMed:15987638). Interacts with ABL1 and ABL2 (PubMed:16678104). Interacts with EMAP2 (PubMed:19362550). Interacts with MAVS (PubMed:19734229).
    • (Microbial infection) Interacts with HIV-1 TAT protein.
    • (Microbial infection) Interacts with hepatitis B virus X protein (HBX).

    Three dimensional structures from OCA and Proteopedia for PSMA7 Gene

    Alternative splice isoforms for PSMA7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMA7 Gene

Protein Expression for PSMA7 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for PSMA7 Gene

O14818:
  • RTVRKIC
  • EKKKQKK
  • VVLGVEK
  • EFLEKNY
  • YDRAITVFSPDG
  • LYQTDPSG
  • RARVECQ
  • IKALLEVVQSGGKNIELA
  • YTQSNGRRPFG
  • EIEKEKEE
  • LFQVEYA
  • EAVKKGSTA
  • EYITRYIA
  • GLTADAR
  • LTVEDPVTVEYITR

Post-translational modifications for PSMA7 Gene

  • Phosphorylation by ABL1 or ABL2 leads to an inhibition of proteasomal activity and cell cycle transition blocks.
  • Glycosylation at Ser130
  • Ubiquitination at Lys115, Lys61, Lys174, Lys204, Lys218, and Lys227
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMA7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PSMA7 Gene

Gene Families for PSMA7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PSMA7 Gene

InterPro:
Blocks:
  • Proteasome subunit, A-type
ProtoNet:

Suggested Antigen Peptide Sequences for PSMA7 Gene

GenScript: Design optimal peptide antigens:
  • Proteasome subunit XAPC7 (PSA7_HUMAN)
  • Proteasome subunit alpha type (Q05DH1_HUMAN)
  • Proteasome (Prosome, macropain) subunit, alpha type, 7 (Q5JXJ1_HUMAN)
  • Proteasome subunit alpha type (Q5JXJ2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O14818

UniProtKB/Swiss-Prot:

PSA7_HUMAN :
  • Belongs to the peptidase T1A family.
Family:
  • Belongs to the peptidase T1A family.
genes like me logo Genes that share domains with PSMA7: view

Function for PSMA7 Gene

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Molecular function for PSMA7 Gene

UniProtKB/Swiss-Prot Function:
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response.
UniProtKB/Swiss-Prot Induction:
Down-regulated by the ribozyme Rz3'X. Up-regulated in colorectal cancer tissues.

Enzyme Numbers (IUBMB) for PSMA7 Gene

Phenotypes From GWAS Catalog for PSMA7 Gene

Gene Ontology (GO) - Molecular Function for PSMA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IBA 21873635
GO:0005515 protein binding IPI 12376572
GO:0042802 identical protein binding IPI 15225636
genes like me logo Genes that share ontologies with PSMA7: view
genes like me logo Genes that share phenotypes with PSMA7: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMA7

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMA7 Gene

Localization for PSMA7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMA7 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMA7 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 4
plasma membrane 3
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PSMA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex TAS,IDA 17323924
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PSMA7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PSMA7 Gene

Pathways & Interactions for PSMA7 Gene

PathCards logo

SuperPathways for PSMA7 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
Activation of APC/C and APC/C-Cdc20 mediated degradation of mitotic proteins
.95
Cdc20-Phospho-APC/C mediated degradation of Cyclin A
.95
Autodegradation of the E3 ubiquitin ligase COP1
.95
Stabilization of p53
.95
Regulation of activated PAK-2p34 by proteasome mediated degradation
.94
Regulation of Apoptosis
.94
CDK-mediated phosphorylation and removal of Cdc6
.94
Ubiquitin-dependent degradation of Cyclin D
.94
Ubiquitin-dependent degradation of Cyclin D1
.94
Orc1 removal from chromatin
.94
Regulation of DNA replication
.94
Switching of origins to a post-replicative state
.94
Cyclin A-Cdk2-associated events at S phase entry
.93
Cyclin E associated events during G1/S transition
.93
APC/C-Cdc20 mediated degradation of Securin
.93
APC/C-Cdh1 mediated degradation of Cdc20 and other APC/C-Cdh1 targeted proteins in late mitosis/early G1
.93
APC/C-mediated degradation of cell cycle proteins
.93
Regulation of APC/C activators between G1/S and early anaphase
.93
Regulation of mitotic cell cycle
.93
DNA Replication
.93
Synthesis of DNA
.93
Vpu mediated degradation of CD4
.93
Autodegradation of Cdh1 by Cdh1-APC/C
.91
SCF-beta-TrCP mediated degradation of Emi1
.91
p53-Independent DNA Damage Response
.91
p53-Independent G1/S DNA damage checkpoint
.91
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
.91
ABC transporter disorders
.91
Disorders of transmembrane transporters
.91
Defective CFTR causes cystic fibrosis
.90
Assembly of the pre-replicative complex
.90
Hedgehog ligand biogenesis
.90
Hh mutants abrogate ligand secretion
.90
APC/C-Cdc20 mediated degradation of mitotic proteins
.89
APC-Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
.89
Vif-mediated degradation of APOBEC3G
.89
Degradation of GLI1 by the proteasome
.89
Degradation of GLI2 by the proteasome
.89
GLI3 is processed to GLI3R by the proteasome
.89
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
.88
Degradation of AXIN
.88
Cellular response to hypoxia
.87
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
.87
Regulation of Hypoxia-inducible Factor (HIF) by oxygen
.87
CDT1 association with the CDC6-ORC-origin complex
.87
Hh mutants that dont undergo autocatalytic processing are degraded by ERAD
.87
AUF1 (hnRNP D0) binds and destabilizes mRNA
.86
p53-Dependent G1 DNA Damage Response
.86
p53-Dependent G1/S DNA damage checkpoint
.86
SCF(Skp2)-mediated degradation of p27/p21
.86
Removal of licensing factors from origins
.86
NIK-->noncanonical NF-kB signaling
.85
Dectin-1 mediated noncanonical NF-kB signaling
.84
G1/S DNA Damage Checkpoints
.84
Degradation of DVL
.83
Cross-presentation of soluble exogenous antigens (endosomes)
.82
The role of GTSE1 in G2/M progression after G2 checkpoint
.81
Regulation of ornithine decarboxylase (ODC)
.81
DNA Replication Pre-Initiation
.80
M/G1 Transition
.80
Proteasome
.80
S Phase
.78
Activation of NF-kappaB in B cells
.77
Asymmetric localization of PCP proteins
.74
FCERI mediated NF-kB activation
.72
Regulation of RAS by GAPs
.70
PCP/CE pathway
.70
Beta-catenin independent WNT signaling
.64
Degradation of beta-catenin by the destruction complex
.64
Regulation of mRNA stability by proteins that bind AU-rich elements
.63
Metabolism of polyamines
.60
ABC-family proteins mediated transport
.58
TNFR2 non-canonical NF-kB pathway
.58
MAPK6/MAPK4 signaling
.57
Proteasome Degradation
.56
UCH proteinases
.47
Canonical Wnt Pathway
.31
Apoptosis
.31
Programmed Cell Death
.31
2 RET signaling
Frs2-mediated activation
.95
GRB2 events in EGFR signaling
.95
MAPK1/MAPK3 signaling
.95
Prolonged ERK activation events
.95
RAF/MAP kinase cascade
.95
SHC1 events in EGFR signaling
.95
Signaling by Leptin
.95
SOS-mediated signalling
.95
VEGFR2 mediated cell proliferation
.95
ARMS-mediated activation
.95
Signalling to ERKs
.95
Signalling to p38 via RIT and RIN
.95
Signalling to RAS
.95
Interleukin receptor SHC signaling
.95
Interleukin-3, 5 and GM-CSF signaling
.94
Interleukin-2 signaling
.94
Downstream signal transduction
.94
Signaling by PDGF
.94
DAP12 signaling
.92
RET signaling
.92
Insulin receptor signalling cascade
.92
Signaling by Insulin receptor
.92
IRS-mediated signalling
.91
Signaling by EGFR
.90
FCERI mediated MAPK activation
.90
IGF1R signaling cascade
.90
IRS-related events triggered by IGF1R
.90
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
.90
DAP12 interactions
.89
NCAM signaling for neurite out-growth
.89
NGF signalling via TRKA from the plasma membrane
.87
MAPK family signaling cascades
.87
Signaling by SCF-KIT
.85
Signalling by NGF
.81
Fc epsilon receptor (FCERI) signaling
.79
VEGFA-VEGFR2 Pathway
.78
Signaling by VEGF
.76
Gastrin-CREB signalling pathway via PKC and MAPK
.55
3 Chks in Checkpoint Regulation
Chks in Checkpoint Regulation
.59
G2-M Phase Transition
.59
Estrogen-mediated S-Phase Entry
.55
SREBP Proteolysis
.43
DNA Repair Mechanisms
.32
Parkinson's Disease Pathway
.31
4 HIV Life Cycle
HIV Infection
.64
Infectious disease
.61
Host Interactions of HIV factors
.57
Disease
.45
Diseases of signal transduction
.43
5 Pathways of neurodegeneration - multiple diseases
Alzheimer disease
.65
Pathways of neurodegeneration - multiple diseases
.65
Amyotrophic lateral sclerosis
.54
Huntington disease
.50
genes like me logo Genes that share pathways with PSMA7: view

Pathways by source for PSMA7 Gene

1 Sino Biological pathway for PSMA7 Gene
1 BioSystems pathway for PSMA7 Gene
4 GeneGo (Thomson Reuters) pathways for PSMA7 Gene
  • Immune response Antigen presentation by MHC class I
  • Regulation of degradation of deltaF508 CFTR in CF
  • Regulation of degradation of wt-CFTR
  • Transcription Ligand-Dependent Transcription of Retinoid-Target genes
18 Qiagen pathways for PSMA7 Gene
  • CDK5 Pathway
  • Chks in Checkpoint Regulation
  • DNA Repair Mechanisms
  • Estrogen-mediated S-Phase Entry
  • G2-M Phase Transition

SIGNOR curated interactions for PSMA7 Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PSMA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
genes like me logo Genes that share ontologies with PSMA7: view

Drugs & Compounds for PSMA7 Gene

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(4) Drugs for PSMA7 Gene - From: DrugBank and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 926
carfilzomib Approved, Investigational Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Experimental Pharma Target 0
acetylleucyl-leucyl-norleucinal Experimental Pharma Target 0
genes like me logo Genes that share compounds with PSMA7: view

Transcripts for PSMA7 Gene

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mRNA/cDNA for PSMA7 Gene

2 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMA7

Alternative Splicing Database (ASD) splice patterns (SP) for PSMA7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: - - - -
SP5: - - -
SP6: - - -
SP7:
SP8: - -
SP9: -

Relevant External Links for PSMA7 Gene

GeneLoc Exon Structure for
PSMA7

Expression for PSMA7 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PSMA7 Gene

mRNA expression in normal human tissues for PSMA7 Gene
mRNA expression by GTEx for PSMA7 GenemRNA expression by BioGPS for PSMA7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PSMA7 Gene

This gene is overexpressed in Muscle - Skeletal (x4.1).

Protein differential expression in normal tissues from HIPED for PSMA7 Gene

This gene is overexpressed in Liver, secretome (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMA7 Gene



Protein tissue co-expression partners for PSMA7 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PSMA7

SOURCE GeneReport for Unigene cluster for PSMA7 Gene:

Hs.233952

Evidence on tissue expression from TISSUES for PSMA7 Gene

  • Nervous system(4.9)
  • Liver(4.8)
  • Lung(4.8)
  • Blood(4.6)
  • Skin(3.6)
  • Eye(3.2)
  • Bone marrow(3.2)
  • Muscle(3)
  • Heart(2.9)
  • Spleen(2.9)
  • Lymph node(2.8)
  • Kidney(2.7)
  • Intestine(2.6)
  • Pancreas(2.4)
  • Bone(2.3)
  • Adrenal gland(2.2)
genes like me logo Genes that share expression patterns with PSMA7: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMA7 Gene

Orthologs for PSMA7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMA7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia PSMA7 30 31
  • 99.46 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia -- 31
  • 98 (a)
 OneToMany
-- 31
  • 78 (a)
 OneToMany
Platypus
(Ornithorhynchus anatinus)
 Mammalia PSMA7 31
  • 97 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia PSMA7 30 31
  • 93.15 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia PSMA7 30 31
  • 92.28 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Psma7 30
  • 91.4 (n)
Mouse
(Mus musculus)
 Mammalia Psma7 30 17 31
  • 90.86 (n)
 OneToOne
Chicken
(Gallus gallus)
 Aves PSMA7 30 31
  • 83.04 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia PSMA7 31
  • 97 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia psma7 30
  • 79.13 (n)
MGC75728 30
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.2813 30
Fruit Fly
(Drosophila melanogaster)
 Insecta Pros28.1 31 32
  • 68 (a)
 ManyToMany
Pros28.1A 31 32
  • 58 (a)
 ManyToMany
Pros28.1B 31 32
  • 50 (a)
 ManyToMany
Worm
(Caenorhabditis elegans)
 Secernentea pas-4 30 31
  • 61.16 (n)
 OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes PRE6 31 33
  • 56 (a)
 OneToMany
Soybean
(Glycine max)
 eudicotyledons Gma.2587 30
Barley
(Hordeum vulgare)
 Liliopsida Hv.3003 30
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.4812 31
  • 76 (a)
 OneToMany
Species where no ortholog for PSMA7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Zebrafish (Danio rerio)

Evolution for PSMA7 Gene

ENSEMBL:
Gene Tree for PSMA7 (if available)
TreeFam:
Gene Tree for PSMA7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PSMA7: view image

Paralogs for PSMA7 Gene

Paralogs for PSMA7 Gene

(8) SIMAP similar genes for PSMA7 Gene using alignment to 3 proteins:

  • PSA7_HUMAN
  • H0Y586_HUMAN
  • Q05DH1_HUMAN

Pseudogenes.org Pseudogenes for PSMA7 Gene

genes like me logo Genes that share paralogs with PSMA7: view

Variants for PSMA7 Gene

Products:

  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PSMA7 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
rs200101662 Likely Benign: not provided 62,139,808(-) G/A
NM_002792.4(PSMA7):c.321C>T (p.Ile107=) 		SYNONYMOUS
rs79987174 Benign: not provided 62,140,809(-) G/A
NM_002792.4(PSMA7):c.223+9C>T 		INTRON
VAR_078692 - p.Ala112Asp

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PSMA7 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PSMA7 Gene

Variant ID Type Subtype PubMed ID
dgv7648n54 CNV gain+loss 21841781
esv1006840 CNV deletion 20482838
esv22512 CNV loss 19812545
nsv1112793 CNV deletion 24896259
nsv1143990 CNV deletion 24896259
nsv3440 CNV insertion 18451855
nsv509782 CNV insertion 20534489
nsv586475 CNV loss 21841781
nsv586476 CNV gain 21841781
nsv586481 CNV gain 21841781

Variation tolerance for PSMA7 Gene

Residual Variation Intolerance Score: 34.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.22; 4.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PSMA7 Gene

Human Gene Mutation Database (HGMD)
PSMA7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMA7

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMA7 Gene

Disorders for PSMA7 Gene

MalaCards: The human disease database

(8) MalaCards diseases for PSMA7 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
hypoxia
hepatitis
  • acute and subacute liver necrosis
duodenum adenoma
hepatitis c virus
  • hepatitis c virus, susceptibility to
hepatitis b
  • chronic hepatitis b
- elite association - COSMIC cancer census association via MalaCards
Search PSMA7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PSMA7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PSMA7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSMA7 Gene

Publications for PSMA7 Gene

  1. Binding and regulation of HIF-1alpha by a subunit of the proteasome complex, PSMA7. (PMID: 11389899) Cho S … Ryu SE (FEBS letters 2001) 3 4 23
  2. Proteasome complex as a potential cellular target of hepatitis B virus X protein. (PMID: 8764072) Huang J … Liang TJ (Journal of virology 1996) 2 3 4
  3. An atomic structure of the human 26S proteasome. (PMID: 27428775) Huang X … Shi Y (Nature structural & molecular biology 2016) 3 4
  4. Crystal structure of the human 20S proteasome in complex with carfilzomib. (PMID: 25599644) Harshbarger W … Sacchettini J (Structure (London, England : 1993) 2015) 3 4
  5. Endothelial monocyte activating polypeptide-II modulates endothelial cell responses by degrading hypoxia-inducible factor-1alpha through interaction with PSMA7, a component of the proteasome. (PMID: 19362550) Tandle AT … Libutti SK (Experimental cell research 2009) 3 4

ExternalLinks

View latest publications for PSMA7 gene in Mastermind

Products for PSMA7 Gene

  • Abcam antibodies for PSMA7
  • Abcam proteins for PSMA7