The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration a... See more...

Aliases for PSMA7 Gene

Aliases for PSMA7 Gene

  • Proteasome 20S Subunit Alpha 7 2 3
  • Proteasome Subunit Alpha 7 2 3 5
  • Proteasome Subunit RC6-1 2 3 4
  • Proteasome Subunit XAPC7 2 3 4
  • Proteasome (Prosome, Macropain) Subunit, Alpha Type, 7 2 3
  • Proteasome Subunit Alpha Type-7 3 4
  • EC 3.4.25.1 4 52
  • HSPC 3 4
  • Epididymis Secretory Protein Li 276 3
  • Testicular Tissue Protein Li 151 3
  • Proteasome Subunit Alpha 4 3
  • Proteasome Subunit Α4 2
  • HEL-S-276 3
  • RC6-1 3
  • XAPC7 3
  • C6 3

External Ids for PSMA7 Gene

Previous GeneCards Identifiers for PSMA7 Gene

  • GC20M060475
  • GC20M061350
  • GC20M061397
  • GC20M060145
  • GC20M060711
  • GC20M057489

Summaries for PSMA7 Gene

Entrez Gene Summary for PSMA7 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the peptidase T1A family that functions as a 20S core alpha subunit. The encoded protein interacts with the hepatitis B virus X protein and plays a role in regulating hepatitis C virus internal ribosome entry site (IRES) activity, an activity essential for viral replication. The encoded protein also plays a role in the cellular stress response by regulating hypoxia-inducible factor-1alpha. A pseudogene of this gene is located on the long arm of chromosome 9. [provided by RefSeq, Jul 2012]

GeneCards Summary for PSMA7 Gene

PSMA7 (Proteasome 20S Subunit Alpha 7) is a Protein Coding gene. Diseases associated with PSMA7 include Hepatitis and Hypoxia. Among its related pathways are Regulation of degradation of deltaF508 CFTR in CF and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include identical protein binding and threonine-type endopeptidase activity. An important paralog of this gene is PSMA8.

UniProtKB/Swiss-Prot Summary for PSMA7 Gene

  • Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response.

Gene Wiki entry for PSMA7 Gene

Additional gene information for PSMA7 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSMA7 Gene

Genomics for PSMA7 Gene

GeneHancer (GH) Regulatory Elements for PSMA7 Gene

Promoters and enhancers for PSMA7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J062140 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 -0.4 -399 6.2 EP300 FOXK2 CTCF SIN3A POLR2G SP1 NCOR1 PHF8 JUND ZFX SS18L1 PSMA7 MTG2 OGFR-AS1 TAF4 piR-49264 HSALNG0131485
GH20J062041 Enhancer 1.1 Ensembl ENCODE 11.2 +95.8 95778 11.8 EP300 NCOR1 ZIC2 ZNF623 TGIF2 SKI TEAD1 ATF2 ZKSCAN8 ZSCAN9 lnc-PSMA7-3 DIDO1 TAF4 LSM14B ENSG00000226332 PSMA7 SS18L1 RPS21 HRH3 LAMA5
GH20J062018 Enhancer 0.8 Ensembl ENCODE 12.3 +122.5 122457 4.8 ZIC2 MXI1 MAFF MAFK RBM22 IKZF1 TAF15 NRF1 EGR1 RXRA PSMA7 SS18L1 CDH4 lnc-PSMA7-5 lnc-PSMA7-4 ENSG00000235018 TAF4
GH20J062010 Enhancer 0.8 ENCODE 12.1 +132.4 132428 0.2 CTCF SIN3A USF1 REST MYC TGIF2 RAD21 SKI TRIM22 SMC3 lnc-PSMA7-5 PSMA7 SS18L1 HRH3 CDH4 ENSG00000235018 lnc-PSMA7-4 TAF4
GH20J062011 Enhancer 0.8 Ensembl 12.1 +132.0 131958 0.6 CTCF SIN3A USF1 MYC TGIF2 SKI TRIM22 MXI1 ZNF341 SMC3 lnc-PSMA7-5 PSMA7 SS18L1 HRH3 ENSG00000235018 lnc-PSMA7-4 TAF4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSMA7 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PSMA7

Top Transcription factor binding sites by QIAGEN in the PSMA7 gene promoter:
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • AP-2alphaA

Genomic Locations for PSMA7 Gene

Genomic Locations for PSMA7 Gene
chr20:62,136,727-62,143,458
(GRCh38/hg38)
Size:
6,732 bases
Orientation:
Minus strand
chr20:60,711,791-60,718,496
(GRCh37/hg19)
Size:
6,706 bases
Orientation:
Minus strand

Genomic View for PSMA7 Gene

Genes around PSMA7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMA7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMA7 Gene

Proteins for PSMA7 Gene

  • Protein details for PSMA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14818-PSA7_HUMAN
    Recommended name:
    Proteasome subunit alpha type-7
    Protein Accession:
    O14818
    Secondary Accessions:
    • B2R515
    • Q5JXJ2
    • Q9BR53
    • Q9H4K5
    • Q9UEU8

    Protein attributes for PSMA7 Gene

    Size:
    248 amino acids
    Molecular mass:
    27887 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. PSMA7 interacts directly with the PSMG1-PSMG2 heterodimer which promotes 20S proteasome assembly (PubMed:16251969). Interacts with HIF1A. Interacts with RAB7A (PubMed:14998988). Interacts with PRKN (PubMed:15987638). Interacts with ABL1 and ABL2 (PubMed:16678104). Interacts with EMAP2 (PubMed:19362550). Interacts with MAVS (PubMed:19734229).
    • (Microbial infection) Interacts with HIV-1 TAT protein.
    • (Microbial infection) Interacts with hepatitis B virus X protein (HBX).

    Three dimensional structures from OCA and Proteopedia for PSMA7 Gene

    Alternative splice isoforms for PSMA7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMA7 Gene

Selected DME Specific Peptides for PSMA7 Gene

O14818:
  • RTVRKIC
  • EKKKQKK
  • VVLGVEK
  • EFLEKNY
  • YDRAITVFSPDG
  • LYQTDPSG
  • RARVECQ
  • IKALLEVVQSGGKNIELA
  • YTQSNGRRPFG
  • EIEKEKEE
  • LFQVEYA
  • EAVKKGSTA
  • EYITRYIA
  • GLTADAR
  • LTVEDPVTVEYITR

Post-translational modifications for PSMA7 Gene

  • Phosphorylation by ABL1 or ABL2 leads to an inhibition of proteasomal activity and cell cycle transition blocks.
  • Glycosylation at Ser130
  • Ubiquitination at Lys115, Lys61, Lys174, Lys204, Lys218, and Lys227
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMA7 Gene

Antibody Products

  • Abcam antibodies for PSMA7
  • Boster Bio Antibodies for PSMA7

Domains & Families for PSMA7 Gene

Gene Families for PSMA7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PSMA7 Gene

Blocks:
  • Proteasome subunit, A-type
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PSMA7 Gene

GenScript: Design optimal peptide antigens:
  • Proteasome subunit XAPC7 (PSA7_HUMAN)
  • Proteasome subunit alpha type (Q05DH1_HUMAN)
  • Proteasome (Prosome, macropain) subunit, alpha type, 7 (Q5JXJ1_HUMAN)
  • Proteasome subunit alpha type (Q5JXJ2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O14818

UniProtKB/Swiss-Prot:

PSA7_HUMAN :
  • Belongs to the peptidase T1A family.
Family:
  • Belongs to the peptidase T1A family.
genes like me logo Genes that share domains with PSMA7: view

Function for PSMA7 Gene

Molecular function for PSMA7 Gene

UniProtKB/Swiss-Prot Function:
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Cleavage of peptide bonds with very broad specificity.; EC=3.4.25.1; Evidence={ECO:0000255 PROSITE-ProRule:PRU00808, ECO:0000269 PubMed:27176742};.
UniProtKB/Swiss-Prot Induction:
Down-regulated by the ribozyme Rz3'X. Up-regulated in colorectal cancer tissues.

Enzyme Numbers (IUBMB) for PSMA7 Gene

Phenotypes From GWAS Catalog for PSMA7 Gene

Gene Ontology (GO) - Molecular Function for PSMA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IBA 21873635
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 12376572
GO:0008233 peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PSMA7: view
genes like me logo Genes that share phenotypes with PSMA7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMA7

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMA7 Gene

Localization for PSMA7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMA7 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMA7 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 3
extracellular 2
cytoskeleton 2
mitochondrion 2
endosome 2
lysosome 2
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PSMA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA,TAS 17323924
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PSMA7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PSMA7 Gene

Pathways & Interactions for PSMA7 Gene

PathCards logo

SuperPathways for PSMA7 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 Chks in Checkpoint Regulation
.59
.59
.55
.43
.32
.31
4 HIV Life Cycle
.45
5 Class I MHC mediated antigen processing and presentation
genes like me logo Genes that share pathways with PSMA7: view

Pathways by source for PSMA7 Gene

1 KEGG pathway for PSMA7 Gene
4 GeneGo (Thomson Reuters) pathways for PSMA7 Gene
  • Immune response Antigen presentation by MHC class I
  • Regulation of degradation of deltaF508 CFTR in CF
  • Regulation of degradation of wt-CFTR
  • Transcription Ligand-Dependent Transcription of Retinoid-Target genes
18 Qiagen pathways for PSMA7 Gene
  • CDK5 Pathway
  • Chks in Checkpoint Regulation
  • DNA Repair Mechanisms
  • Estrogen-mediated S-Phase Entry
  • G2-M Phase Transition

SIGNOR curated interactions for PSMA7 Gene

Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PSMA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PSMA7: view

Drugs & Compounds for PSMA7 Gene

(4) Drugs for PSMA7 Gene - From: DrugBank and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 888
carfilzomib Approved, Investigational Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Experimental Pharma Target 0
acetylleucyl-leucyl-norleucinal Experimental Pharma Target 0
genes like me logo Genes that share compounds with PSMA7: view

Transcripts for PSMA7 Gene

mRNA/cDNA for PSMA7 Gene

2 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMA7

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMA7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: - - - -
SP5: - - -
SP6: - - -
SP7:
SP8: - -
SP9: -

Relevant External Links for PSMA7 Gene

GeneLoc Exon Structure for
PSMA7

Expression for PSMA7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PSMA7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PSMA7 Gene

This gene is overexpressed in Muscle - Skeletal (x4.1).

Protein differential expression in normal tissues from HIPED for PSMA7 Gene

This gene is overexpressed in Liver, secretome (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMA7 Gene



Protein tissue co-expression partners for PSMA7 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PSMA7

SOURCE GeneReport for Unigene cluster for PSMA7 Gene:

Hs.233952

Evidence on tissue expression from TISSUES for PSMA7 Gene

  • Liver(4.8)
  • Nervous system(4.8)
  • Blood(4.7)
  • Lung(4.7)
  • Bone marrow(3.7)
  • Skin(3.2)
  • Eye(2.9)
  • Spleen(2.8)
  • Heart(2.7)
  • Lymph node(2.4)
  • Muscle(2.4)
  • Bone(2.3)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with PSMA7: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMA7 Gene

Orthologs for PSMA7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMA7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMA7 31 30
  • 99.46 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 98 (a)
OneToMany
-- 31
  • 78 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia PSMA7 31
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PSMA7 31 30
  • 93.15 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PSMA7 31 30
  • 92.28 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psma7 30
  • 91.4 (n)
mouse
(Mus musculus)
Mammalia Psma7 17 31 30
  • 90.86 (n)
chicken
(Gallus gallus)
Aves PSMA7 31 30
  • 83.04 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSMA7 31
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psma7 30
  • 79.13 (n)
MGC75728 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2813 30
fruit fly
(Drosophila melanogaster)
Insecta Pros28.1 31 32
  • 68 (a)
ManyToMany
Pros28.1A 31 32
  • 58 (a)
ManyToMany
Pros28.1B 31 32
  • 50 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea pas-4 31 30
  • 61.16 (n)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRE6 33 31
  • 56 (a)
soybean
(Glycine max)
eudicotyledons Gma.2587 30
barley
(Hordeum vulgare)
Liliopsida Hv.3003 30
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4812 31
  • 76 (a)
OneToMany
Species where no ortholog for PSMA7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for PSMA7 Gene

ENSEMBL:
Gene Tree for PSMA7 (if available)
TreeFam:
Gene Tree for PSMA7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PSMA7: view image

Paralogs for PSMA7 Gene

(8) SIMAP similar genes for PSMA7 Gene using alignment to 3 proteins:

  • PSA7_HUMAN
  • H0Y586_HUMAN
  • Q05DH1_HUMAN

Pseudogenes.org Pseudogenes for PSMA7 Gene

genes like me logo Genes that share paralogs with PSMA7: view

Variants for PSMA7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PSMA7 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
754641 Likely Benign: not provided 62,139,808(-) G/A SYNONYMOUS_VARIANT
777604 Benign: not provided 62,140,809(-) G/A INTRON_VARIANT
VAR_078692 - p.Ala112Asp

Additional dbSNP identifiers (rs#s) for PSMA7 Gene

Structural Variations from Database of Genomic Variants (DGV) for PSMA7 Gene

Variant ID Type Subtype PubMed ID
dgv7648n54 CNV gain+loss 21841781
esv1006840 CNV deletion 20482838
esv22512 CNV loss 19812545
nsv1112793 CNV deletion 24896259
nsv1143990 CNV deletion 24896259
nsv3440 CNV insertion 18451855
nsv509782 CNV insertion 20534489
nsv586475 CNV loss 21841781
nsv586476 CNV gain 21841781
nsv586481 CNV gain 21841781

Variation tolerance for PSMA7 Gene

Residual Variation Intolerance Score: 34.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.22; 4.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PSMA7 Gene

Human Gene Mutation Database (HGMD)
PSMA7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMA7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMA7 Gene

Disorders for PSMA7 Gene

MalaCards: The human disease database

(13) MalaCards diseases for PSMA7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hepatitis
  • hepatitis a
hypoxia
hepatitis c virus
  • hepatitis c virus, susceptibility to
hepatitis b
  • chronic hepatitis b
duodenum adenoma
- elite association - COSMIC cancer census association via MalaCards
Search PSMA7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PSMA7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PSMA7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSMA7 Gene

Publications for PSMA7 Gene

  1. Binding and regulation of HIF-1alpha by a subunit of the proteasome complex, PSMA7. (PMID: 11389899) Cho S … Ryu SE (FEBS letters 2001) 3 4 23 54
  2. Proteasome complex as a potential cellular target of hepatitis B virus X protein. (PMID: 8764072) Huang J … Liang TJ (Journal of virology 1996) 2 3 4 54
  3. An atomic structure of the human 26S proteasome. (PMID: 27428775) Huang X … Shi Y (Nature structural & molecular biology 2016) 3 4 54
  4. Crystal structure of the human 20S proteasome in complex with carfilzomib. (PMID: 25599644) Harshbarger W … Sacchettini J (Structure (London, England : 1993) 2015) 3 4 54
  5. Endothelial monocyte activating polypeptide-II modulates endothelial cell responses by degrading hypoxia-inducible factor-1alpha through interaction with PSMA7, a component of the proteasome. (PMID: 19362550) Tandle AT … Libutti SK (Experimental cell research 2009) 3 4 54

Products for PSMA7 Gene