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The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the peptidase T1A family that functions as a 20S core alpha subunit. The encoded protein interacts with the hepatitis B virus X protein and plays a role in regulating hepatitis C virus internal ribosome entry site (IRES) activity, an activity essential for viral replication. The encoded protein also plays a role in the cellular stress response by regulating hypoxia-inducible factor-1alpha. A pseudogene of this gene is located on the long arm of chromosome 9. [provided by RefSeq, Jul 2012]
PSMA7 (Proteasome 20S Subunit Alpha 7) is a Protein Coding gene. Diseases associated with PSMA7 include Hypoxia and Hepatitis. Among its related pathways are Downstream signaling events of B Cell Receptor (BCR) and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include identical protein binding and threonine-type endopeptidase activity. An important paralog of this gene is PSMA8.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004175 | endopeptidase activity | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 12376572 |
GO:0042802 | identical protein binding | IPI | 15225636 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000502 | proteasome complex | TAS,IDA | 17323924 |
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | CDK-mediated phosphorylation and removal of Cdc6 |
.93
.93
|
.80
.80
.78
.70
.47
.31
|
2 | RET signaling |
.92
|
.92
|
3 | Chks in Checkpoint Regulation |
Chks in Checkpoint Regulation
.59
G2-M Phase Transition
.59
Estrogen-mediated S-Phase Entry
.55
|
SREBP Proteolysis
.43
DNA Repair Mechanisms
.32
Parkinson's Disease Pathway
.31
|
4 | HIV Life Cycle |
.64
|
.45
|
5 | Pathways of neurodegeneration - multiple diseases |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000165 | MAPK cascade | TAS | -- |
GO:0000209 | protein polyubiquitination | TAS | -- |
GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
GO:0006511 | ubiquitin-dependent protein catabolic process | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Bortezomib | Approved, Investigational | Pharma | inhibitor, other | Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors | 926 | |
carfilzomib | Approved, Investigational | Pharma | other, Inhibitor | Other, 20S Proteasome Inhibitor | 0 | |
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE | Experimental | Pharma | Target | 0 | ||
acetylleucyl-leucyl-norleucinal | Experimental | Pharma | Target | 0 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP7: | |||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | |||||||||||||||||||||||||||||||||||||||
SP9: | - |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PSMA7 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Platypus (Ornithorhynchus anatinus) |
Mammalia | PSMA7 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PSMA7 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PSMA7 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Psma7 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Psma7 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | PSMA7 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | PSMA7 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | psma7 30 |
|
||
MGC75728 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.2813 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Pros28.1 31 32 |
|
ManyToMany | |
Pros28.1A 31 32 |
|
ManyToMany | |||
Pros28.1B 31 32 |
|
ManyToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | pas-4 30 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PRE6 31 33 |
|
OneToMany | |
Soybean (Glycine max) |
eudicotyledons | Gma.2587 30 |
|
||
Barley (Hordeum vulgare) |
Liliopsida | Hv.3003 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.4812 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 20 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs200101662 | Likely Benign: not provided | 62,139,808(-) |
G/A NM_002792.4(PSMA7):c.321C>T (p.Ile107=) |
SYNONYMOUS | |
rs79987174 | Benign: not provided | 62,140,809(-) |
G/A NM_002792.4(PSMA7):c.223+9C>T |
INTRON | |
VAR_078692 | - |
p.Ala112Asp |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv7648n54 | CNV | gain+loss | 21841781 |
esv1006840 | CNV | deletion | 20482838 |
esv22512 | CNV | loss | 19812545 |
nsv1112793 | CNV | deletion | 24896259 |
nsv1143990 | CNV | deletion | 24896259 |
nsv3440 | CNV | insertion | 18451855 |
nsv509782 | CNV | insertion | 20534489 |
nsv586475 | CNV | loss | 21841781 |
nsv586476 | CNV | gain | 21841781 |
nsv586481 | CNV | gain | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
hypoxia |
|
|
hepatitis |
|
|
duodenum adenoma |
|
|
hepatitis c virus |
|
|
hepatitis b |
|
|