This gene encodes a core alpha subunit of the 20S proteosome, which is a highly ordered ring-shaped structure composed of four rings of 28 non-identical subunits. Proteasomes cleave peptides in an ATP- and ubiquitin-dependent manner. [provided by RefSeq, Aug 2016] See more...

Aliases for PSMA4 Gene

Aliases for PSMA4 Gene

  • Proteasome 20S Subunit Alpha 4 2 3
  • Proteasome Subunit Alpha 4 2 3 5
  • Proteasome (Prosome, Macropain) Subunit, Alpha Type, 4 2 3
  • Multicatalytic Endopeptidase Complex Subunit C9 3 4
  • Proteasome Subunit Alpha Type-4 3 4
  • Proteasome Component C9 3 4
  • Macropain Subunit C9 3 4
  • Proteasome Subunit L 3 4
  • EC 3.4.25.1 4 52
  • PSC9 3 4
  • HC9 3 4
  • Proteasome Subunit Alpha3 3
  • Proteasome Subunit HC9 3
  • Proteasome Subunit Α3 2
  • HsT17706 3

External Ids for PSMA4 Gene

Previous GeneCards Identifiers for PSMA4 Gene

  • GC15P074911
  • GC15P071922
  • GC15P076408
  • GC15P076548
  • GC15P076619
  • GC15P078832
  • GC15P055589

Summaries for PSMA4 Gene

Entrez Gene Summary for PSMA4 Gene

  • This gene encodes a core alpha subunit of the 20S proteosome, which is a highly ordered ring-shaped structure composed of four rings of 28 non-identical subunits. Proteasomes cleave peptides in an ATP- and ubiquitin-dependent manner. [provided by RefSeq, Aug 2016]

GeneCards Summary for PSMA4 Gene

PSMA4 (Proteasome 20S Subunit Alpha 4) is a Protein Coding gene. Diseases associated with PSMA4 include Cystic Fibrosis and Tobacco Addiction. Among its related pathways are Regulation of degradation of deltaF508 CFTR in CF and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include endopeptidase activity and threonine-type endopeptidase activity. An important paralog of this gene is PSMA8.

UniProtKB/Swiss-Prot Summary for PSMA4 Gene

  • Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).

Gene Wiki entry for PSMA4 Gene

Additional gene information for PSMA4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSMA4 Gene

Genomics for PSMA4 Gene

GeneHancer (GH) Regulatory Elements for PSMA4 Gene

Promoters and enhancers for PSMA4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSMA4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PSMA4

Top Transcription factor binding sites by QIAGEN in the PSMA4 gene promoter:
  • AREB6
  • Evi-1
  • FOXO1
  • FOXO1a
  • Nkx2-5
  • Pax-5
  • Pbx1a
  • PPAR-gamma1
  • PPAR-gamma2
  • Sox5

Genomic Locations for PSMA4 Gene

Genomic Locations for PSMA4 Gene
chr15:78,540,405-78,552,417
(GRCh38/hg38)
Size:
12,013 bases
Orientation:
Plus strand
chr15:78,832,747-78,841,604
(GRCh37/hg19)
Size:
8,858 bases
Orientation:
Plus strand

Genomic View for PSMA4 Gene

Genes around PSMA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMA4 Gene

Proteins for PSMA4 Gene

  • Protein details for PSMA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25789-PSA4_HUMAN
    Recommended name:
    Proteasome subunit alpha type-4
    Protein Accession:
    P25789
    Secondary Accessions:
    • D3DW86
    • Q53XP2
    • Q567Q5
    • Q8TBD1

    Protein attributes for PSMA4 Gene

    Size:
    261 amino acids
    Molecular mass:
    29484 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.
    • (Microbial infection) Interaction with HTLV-1 TAX protein favors NFKB1 activation.

    Three dimensional structures from OCA and Proteopedia for PSMA4 Gene

    Alternative splice isoforms for PSMA4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMA4 Gene

Selected DME Specific Peptides for PSMA4 Gene

P25789:
  • SDPSGNY
  • TIFSPEGR
  • RPFGVSLL
  • HAGTCLGIL
  • GKTVIRVLKQKEVEQLIKKHEEEEAKAEREKKEKEQ
  • GWKATCIG
  • ELRLIAQRY
  • SMLKQDY
  • FSPEGRL
  • VAGITSDAN
  • CDIKQAYTQ
  • KVLNKTMDVSKLSAEKVEIATLTRE

Post-translational modifications for PSMA4 Gene

  • Ubiquitination at Lys54, Lys127, Lys64, Lys67, Lys176, Lys195, Lys199, Lys205, Lys210, Lys231, and Lys238
  • Modification sites at PhosphoSitePlus

Domains & Families for PSMA4 Gene

Gene Families for PSMA4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PSMA4 Gene

Blocks:
  • Proteasome subunit, A-type
  • Proteasome B-type subunit
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PSMA4 Gene

GenScript: Design optimal peptide antigens:
  • Proteasome subunit L (PSA4_HUMAN)
  • Proteasome subunit beta type (Q7Z474_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P25789

UniProtKB/Swiss-Prot:

PSA4_HUMAN :
  • Belongs to the peptidase T1A family.
Family:
  • Belongs to the peptidase T1A family.
genes like me logo Genes that share domains with PSMA4: view

Function for PSMA4 Gene

Molecular function for PSMA4 Gene

UniProtKB/Swiss-Prot Function:
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Cleavage of peptide bonds with very broad specificity.; EC=3.4.25.1; Evidence={ECO:0000255 PROSITE-ProRule:PRU00808, ECO:0000269 PubMed:27176742};.
UniProtKB/Swiss-Prot Induction:
Down-regulated by antioxidants BO-653 and probucol.

Enzyme Numbers (IUBMB) for PSMA4 Gene

Phenotypes From GWAS Catalog for PSMA4 Gene

Gene Ontology (GO) - Molecular Function for PSMA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IEA,IBA 21873635
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 12376572
GO:0008233 peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PSMA4: view
genes like me logo Genes that share phenotypes with PSMA4: view

Animal Model Products

CRISPR Products

miRNA for PSMA4 Gene

miRTarBase miRNAs that target PSMA4

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMA4 Gene

Localization for PSMA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMA4 Gene

Cytoplasm. Nucleus. Note=Colocalizes with TRIM5 in the cytoplasmic bodies. {ECO:0000250 UniProtKB:Q9R1P0}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMA4 gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 2
mitochondrion 2
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PSMA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA,IEA 17323924
GO:0000932 P-body ISS --
GO:0005634 nucleus IBA,IDA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IBA 21873635
genes like me logo Genes that share ontologies with PSMA4: view

Pathways & Interactions for PSMA4 Gene

PathCards logo

SuperPathways for PSMA4 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 Chks in Checkpoint Regulation
.59
.59
.55
.43
.32
.31
4 HIV Life Cycle
.45
5 Class I MHC mediated antigen processing and presentation
genes like me logo Genes that share pathways with PSMA4: view

Pathways by source for PSMA4 Gene

1 KEGG pathway for PSMA4 Gene
4 GeneGo (Thomson Reuters) pathways for PSMA4 Gene
  • Immune response Antigen presentation by MHC class I
  • Regulation of degradation of deltaF508 CFTR in CF
  • Regulation of degradation of wt-CFTR
  • Transcription Ligand-Dependent Transcription of Retinoid-Target genes
17 Qiagen pathways for PSMA4 Gene
  • CDK5 Pathway
  • Chks in Checkpoint Regulation
  • DNA Repair Mechanisms
  • Estrogen-mediated S-Phase Entry
  • G2-M Phase Transition

Gene Ontology (GO) - Biological Process for PSMA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PSMA4: view

No data available for SIGNOR curated interactions for PSMA4 Gene

Drugs & Compounds for PSMA4 Gene

(4) Drugs for PSMA4 Gene - From: DrugBank, PharmGKB, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 888
carfilzomib Approved, Investigational Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Experimental Pharma Target 0
cotinine Pharma 0
genes like me logo Genes that share compounds with PSMA4: view

Transcripts for PSMA4 Gene

mRNA/cDNA for PSMA4 Gene

6 REFSEQ mRNAs :
23 NCBI additional mRNA sequence :
21 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMA4 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - -
SP5: -
SP6: -
SP7:
SP8: -

Relevant External Links for PSMA4 Gene

GeneLoc Exon Structure for
PSMA4

Expression for PSMA4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PSMA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PSMA4 Gene

This gene is overexpressed in Nasal epithelium (6.3) and Liver, secretome (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMA4 Gene



Protein tissue co-expression partners for PSMA4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PSMA4

SOURCE GeneReport for Unigene cluster for PSMA4 Gene:

Hs.251531

Evidence on tissue expression from TISSUES for PSMA4 Gene

  • Nervous system(4.9)
  • Liver(4.7)
  • Lung(4.6)
  • Blood(4.3)
  • Pancreas(4.3)
  • Skin(3.1)
  • Kidney(3)
  • Muscle(2.2)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with PSMA4: view

Primer Products