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Aliases for PSMA4 Gene

Aliases for PSMA4 Gene

  • Proteasome Subunit Alpha 4 2 3 5
  • Proteasome (Prosome, Macropain) Subunit, Alpha Type, 4 2 3
  • Multicatalytic Endopeptidase Complex Subunit C9 3 4
  • Proteasome Component C9 3 4
  • Macropain Subunit C9 3 4
  • Proteasome Subunit L 3 4
  • EC 3.4.25.1 4 56
  • PSC9 3 4
  • HC9 3 4
  • Proteasome Subunit Alpha Type-4 3
  • Proteasome Subunit HC9 3
  • HsT17706 3

External Ids for PSMA4 Gene

Previous GeneCards Identifiers for PSMA4 Gene

  • GC15P074911
  • GC15P071922
  • GC15P076408
  • GC15P076548
  • GC15P076619
  • GC15P078832
  • GC15P055589

Summaries for PSMA4 Gene

Entrez Gene Summary for PSMA4 Gene

  • This gene encodes a core alpha subunit of the 20S proteosome, which is a highly ordered ring-shaped structure composed of four rings of 28 non-identical subunits. Proteasomes cleave peptides in an ATP- and ubiquitin-dependent manner. [provided by RefSeq, Aug 2016]

GeneCards Summary for PSMA4 Gene

PSMA4 (Proteasome Subunit Alpha 4) is a Protein Coding gene. Among its related pathways are RET signaling and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include endopeptidase activity and threonine-type endopeptidase activity.

UniProtKB/Swiss-Prot for PSMA4 Gene

  • Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).

Gene Wiki entry for PSMA4 Gene

Additional gene information for PSMA4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMA4 Gene

Genomics for PSMA4 Gene

GeneHancer (GH) Regulatory Elements for PSMA4 Gene

Promoters and enhancers for PSMA4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I078539 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 564.8 +0.6 600 3 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 PSMA4 CHRNA5 HYKK IREB2 GC15M078021
GH15I078871 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 20.5 +333.4 333402 4.6 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 MORF4L1 IREB2 ENSG00000259562 PSMA4 TBC1D2B RNU6-415P ENSG00000260988 WDR61 LOC100129540 ENSG00000259322
GH15I078564 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 13.8 +25.4 25422 2.2 HDGF ARNT ARID4B SIN3A TCF12 ELK1 ZNF143 SP3 NCOA1 REST CHRNA5 PSMA4 IREB2 TBC1D2B HYKK MORF4L1 ADAMTS7 CRABP1 RASGRF1 ENSG00000261762
GH15I078453 Enhancer 1.3 Ensembl ENCODE dbSUPER 19.9 -85.0 -84952 4.5 PKNOX1 NFIB INSM2 MZF1 FEZF1 ZNF335 ZNF121 ZNF366 ZSCAN5C SCRT2 PSMA4 IREB2 WDR61 CRABP1 ENSG00000259474 GC15M078021
GH15I078506 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.5 -32.6 -32625 2.1 PKNOX1 ATF1 FOXA2 ARID4B SIN3A ZNF48 YY1 POLR2B GLIS2 FOS HYKK IREB2 PSMA4 ENSG00000279373 GC15M078021
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PSMA4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PSMA4 gene promoter:

Genomic Locations for PSMA4 Gene

Genomic Locations for PSMA4 Gene
chr15:78,540,405-78,552,419
(GRCh38/hg38)
Size:
12,015 bases
Orientation:
Plus strand
chr15:78,832,747-78,841,604
(GRCh37/hg19)

Genomic View for PSMA4 Gene

Genes around PSMA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMA4 Gene

Proteins for PSMA4 Gene

  • Protein details for PSMA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25789-PSA4_HUMAN
    Recommended name:
    Proteasome subunit alpha type-4
    Protein Accession:
    P25789
    Secondary Accessions:
    • D3DW86
    • Q53XP2
    • Q567Q5
    • Q8TBD1

    Protein attributes for PSMA4 Gene

    Size:
    261 amino acids
    Molecular mass:
    29484 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. Interaction with HTLV-1 TAX protein favors NFKB1 activation (PubMed:8692272).

    Three dimensional structures from OCA and Proteopedia for PSMA4 Gene

    Alternative splice isoforms for PSMA4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMA4 Gene

Selected DME Specific Peptides for PSMA4 Gene

P25789:
  • SDPSGNY
  • TIFSPEGR
  • RPFGVSLL
  • HAGTCLGIL
  • GKTVIRVLKQKEVEQLIKKHEEEEAKAEREKKEKEQ
  • GWKATCIG
  • ELRLIAQRY
  • SMLKQDY
  • FSPEGRL
  • VAGITSDAN
  • CDIKQAYTQ
  • KVLNKTMDVSKLSAEKVEIATLTRE

Post-translational modifications for PSMA4 Gene

  • Ubiquitination at Lys54, isoforms=64, isoforms=67, Lys127, isoforms=2176, isoforms=2195, isoforms=2199, isoforms=2205, Lys210, Lys231, and Lys238
  • Modification sites at PhosphoSitePlus

Domains & Families for PSMA4 Gene

Gene Families for PSMA4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PSMA4 Gene

Graphical View of Domain Structure for InterPro Entry

P25789

UniProtKB/Swiss-Prot:

PSA4_HUMAN :
  • Belongs to the peptidase T1A family.
Family:
  • Belongs to the peptidase T1A family.
genes like me logo Genes that share domains with PSMA4: view

Function for PSMA4 Gene

Molecular function for PSMA4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of peptide bonds with very broad specificity.
UniProtKB/Swiss-Prot Function:
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
UniProtKB/Swiss-Prot Induction:
Down-regulated by antioxidants BO-653 and probucol.

Enzyme Numbers (IUBMB) for PSMA4 Gene

Phenotypes From GWAS Catalog for PSMA4 Gene

Gene Ontology (GO) - Molecular Function for PSMA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IEA --
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 12376572
GO:0008233 peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PSMA4: view
genes like me logo Genes that share phenotypes with PSMA4: view

Animal Model Products

miRNA for PSMA4 Gene

miRTarBase miRNAs that target PSMA4

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMA4 Gene

Localization for PSMA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMA4 Gene

Cytoplasm. Nucleus. Note=Colocalizes with TRIM5 in the cytoplasmic bodies. {ECO:0000250 UniProtKB:Q9R1P0}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMA4 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 2
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleus (3)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PSMA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA,IEA 17323924
GO:0000932 P-body ISS --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PSMA4: view

Pathways & Interactions for PSMA4 Gene

SuperPathways for PSMA4 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 Chks in Checkpoint Regulation
4 HIV Life Cycle
.45
5 Class I MHC mediated antigen processing and presentation
genes like me logo Genes that share pathways with PSMA4: view

Gene Ontology (GO) - Biological Process for PSMA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PSMA4: view

No data available for SIGNOR curated interactions for PSMA4 Gene

Drugs & Compounds for PSMA4 Gene

(4) Drugs for PSMA4 Gene - From: DrugBank, PharmGKB, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 826
carfilzomib Approved, Investigational Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Experimental Pharma Target 0
cotinine Pharma 0
genes like me logo Genes that share compounds with PSMA4: view

Transcripts for PSMA4 Gene

Unigene Clusters for PSMA4 Gene

Proteasome (prosome, macropain) subunit, alpha type, 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMA4 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - -
SP5: -
SP6: -
SP7:
SP8: -

Relevant External Links for PSMA4 Gene

GeneLoc Exon Structure for
PSMA4
ECgene alternative splicing isoforms for
PSMA4

Expression for PSMA4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSMA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PSMA4 Gene

This gene is overexpressed in Nasal epithelium (6.3) and Liver, secretome (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSMA4 Gene



Protein tissue co-expression partners for PSMA4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PSMA4 Gene:

PSMA4

SOURCE GeneReport for Unigene cluster for PSMA4 Gene:

Hs.251531

Evidence on tissue expression from TISSUES for PSMA4 Gene

  • Nervous system(4.9)
  • Liver(4.7)
  • Lung(4.5)
  • Blood(4.3)
  • Pancreas(4.3)
  • Skin(3.1)
  • Kidney(3)
  • Muscle(2.2)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with PSMA4: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMA4 Gene

Orthologs for PSMA4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMA4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMA4 33 34
  • 99.87 (n)
oppossum
(Monodelphis domestica)
Mammalia PSMA4 34
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSMA4 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PSMA4 33 34
  • 95.15 (n)
rat
(Rattus norvegicus)
Mammalia Psma4 33
  • 91.83 (n)
mouse
(Mus musculus)
Mammalia Psma4 33 16 34
  • 91.32 (n)
chicken
(Gallus gallus)
Aves PSMA4 33 34
  • 84.29 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia psma4 33
  • 84.39 (n)
Str.8679 33
zebrafish
(Danio rerio)
Actinopterygii psma4 33 34
  • 76.93 (n)
Dr.10596 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9056 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004960 33
  • 65.12 (n)
fruit fly
(Drosophila melanogaster)
Insecta Pros29 35 33 34
  • 63.85 (n)
Prosalpha3T 35 34
  • 56 (a)
worm
(Caenorhabditis elegans)
Secernentea pas-3 33 34
  • 60.26 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRE9 33 34 36
  • 56.31 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E03917g 33
  • 55.32 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR318W 33
  • 53.9 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons PAC1 33
  • 61.58 (n)
soybean
(Glycine max)
eudicotyledons Gma.3753 33
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.8126 33
rice
(Oryza sativa)
Liliopsida Os06g0176000 33
  • 56.97 (n)
corn
(Zea mays)
Liliopsida Zm.6197 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.27 34
  • 75 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC13C5.01c 33
  • 59.46 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU05942 33
  • 57.06 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2454 33
Species where no ortholog for PSMA4 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSMA4 Gene

ENSEMBL:
Gene Tree for PSMA4 (if available)
TreeFam:
Gene Tree for PSMA4 (if available)

Paralogs for PSMA4 Gene

Pseudogenes.org Pseudogenes for PSMA4 Gene

genes like me logo Genes that share paralogs with PSMA4: view

No data available for Paralogs for PSMA4 Gene

Variants for PSMA4 Gene

Sequence variations from dbSNP and Humsavar for PSMA4 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000076421 -- 78,539,981(+) A/G upstream_transcript_variant
rs1000674273 -- 78,540,862(+) G/A/C intron_variant
rs1000774740 -- 78,547,995(+) C/T intron_variant
rs1001025077 -- 78,541,041(+) C/T intron_variant
rs1001272041 -- 78,547,201(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PSMA4 Gene

Variant ID Type Subtype PubMed ID
nsv1038816 CNV gain 25217958
nsv1116464 OTHER inversion 24896259

Variation tolerance for PSMA4 Gene

Residual Variation Intolerance Score: 33.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PSMA4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMA4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMA4 Gene

Disorders for PSMA4 Gene

Additional Disease Information for PSMA4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PSMA4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMA4 Gene

Publications for PSMA4 Gene

  1. Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes). (PMID: 2025653) Tamura T … Ichihara A (Biochimica et biophysica acta 1991) 2 3 4 58
  2. Crystal structure of the human 20S proteasome in complex with carfilzomib. (PMID: 25599644) Harshbarger W … Sacchettini J (Structure (London, England : 1993) 2015) 3 4 58
  3. Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis. (PMID: 22491018) Wang J … Platt A (The pharmacogenomics journal 2013) 3 44 58
  4. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M … Yamada Y (American journal of hypertension 2010) 3 44 58
  5. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T … Yamada Y (International journal of molecular medicine 2010) 3 44 58

Products for PSMA4 Gene