Aliases for PSMA3 Gene
Aliases for PSMA3 Gene
External Ids for PSMA3 Gene
- HGNC: 9532
- Entrez Gene: 5684
- Ensembl: ENSG00000100567
- OMIM: 176843
- UniProtKB: P25788
Previous GeneCards Identifiers for PSMA3 Gene
- GC14P056035
- GC14P052507
- GC14P056701
- GC14P057781
- GC14P058711
- GC14P038877
Summaries for PSMA3 Gene
-
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for PSMA3 Gene
PSMA3 (Proteasome Subunit Alpha 3) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and RET signaling. Gene Ontology (GO) annotations related to this gene include endopeptidase activity and threonine-type endopeptidase activity.
UniProtKB/Swiss-Prot for PSMA3 Gene
-
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMA3 Gene
Genomics for PSMA3 Gene
GeneHancer (GH) Regulatory Elements for PSMA3 Gene
Promoters and enhancers for PSMA3 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH14J058242 | Promoter/Enhancer | 2.2 | EPDnew Ensembl ENCODE dbSUPER | 650.7 | -0.2 | -200 | 3.6 | HDGF PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B | PSMA3 RNU6-341P ARID4A ARMH4 PSMA3-AS1 ENSG00000258682 TRK-CTT1-1 GC14P058110 | |
| GH14J058271 | Enhancer | 1.1 | ENCODE dbSUPER | 0.3 | +27.8 | 27822 | 2 | FOXA2 MLX ARID4B DMAP1 YY1 PAF1 RXRA REST PPARG KAT8 | PIR55001 KIAA0586 ENSG00000258682 HMGB1P14 ARMH4 PSMA3 PSMA3-AS1 | |
| GH14J058260 | Enhancer | 0.2 | FANTOM5 | 0.4 | +15.6 | 15615 | 0.6 | RNU6-341P TOMM20L ENSG00000258682 PSMA3 ARMH4 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PSMA3 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PSMA3 gene promoter:
-
- AP-1
- c-Jun
- ATF-2
- NF-AT
- NF-AT1
- NF-AT2
- NF-AT3
Regulatory Element Products
Genomic Locations for PSMA3 Gene
Genomic Locations for PSMA3 Gene
- chr14:58,244,805-58,272,012
- (GRCh38/hg38)
- Size:
- 27,208 bases
- Orientation:
- Plus strand
- chr14:58,711,523-58,738,730
- (GRCh37/hg19)
- Size:
- 27,208 bases
- Orientation:
- Plus strand
Genomic View for PSMA3 Gene
Genes around PSMA3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q23.1 by Entrez Gene
- 14q23.1 by HGNC
- 14q23.1 by Ensembl
PSMA3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PSMA3 Gene
Proteins for PSMA3 Gene
-
Protein details for PSMA3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P25788-PSA3_HUMAN
- Recommended name:
- Proteasome subunit alpha type-3
- Protein Accession:
- P25788
- B2RCK6
- Q86U83
- Q8N1D8
- Q9BS70
Protein attributes for PSMA3 Gene
- Size:
- 255 amino acids
- Molecular mass:
- 28433 Da
- Quaternary structure:
-
- The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. Interacts with AURKB. Interacts with CDKN1A (PubMed:11350925). Interacts with HIV-1 TAT protein (PubMed:14550573). Interacts with hepatitis C virus (HCV) F protein (PubMed:18971267). Interacts with Epstein-Barr virus EBNA3 proteins (PubMed:15831937). Interacts with MDM2 and RB1 (PubMed:16337594). Interacts with the C-terminus of TBXA2R isoform 2 (PubMed:17499743). Interacts with DNAJB2 (PubMed:15936278).
Three dimensional structures from OCA and Proteopedia for PSMA3 Gene
Protein Expression for PSMA3 Gene
Post-translational modifications for PSMA3 Gene
Other Protein References for PSMA3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for PSMA3
- Invitrogen Antibodies for PSMA3
- GeneTex PSMA3 Antibody for PSMA3
-
Boster Bio Antibodies for PSMA3
-
Santa Cruz Biotechnology (SCBT) Antibodies for PSMA3
- Sino Biological Antibodies for PSMA3
Protein Products
-
OriGene Purified Proteins for PSMA3
- Search Origene for MassSpec and Protein Over-expression Lysates for PSMA3
- Origene Custom Protein Services for PSMA3
- Sino Biological Recombinant Proteins for PSMA3
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for PSMA3
- Search GeneTex for Proteins for PSMA3
Assay Products
No data available for DME Specific Peptides for PSMA3 Gene
Domains & Families for PSMA3 Gene
Gene Families for PSMA3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for PSMA3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PSMA3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P25788- Family:
-
- Belongs to the peptidase T1A family.
Function for PSMA3 Gene
Molecular function for PSMA3 Gene
- UniProtKB/Swiss-Prot Function:
- Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Cleavage of peptide bonds with very broad specificity.
- UniProtKB/Swiss-Prot Induction:
- Down-regulated by antioxidants BO-653 and probucol. Up-regulated by bacterial lipopolysaccharides (LPS) and TNF.
- GENATLAS Biochemistry:
- multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,alpha type 3,subunit HC8
Enzyme Numbers (IUBMB) for PSMA3 Gene
Phenotypes From GWAS Catalog for PSMA3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004175 | endopeptidase activity | IEA,IBA | -- |
| GO:0004298 | threonine-type endopeptidase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 11146632 |
| GO:0008233 | peptidase activity | IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for PSMA3 Gene
- GenomeRNAi human phenotypes for PSMA3:
-
- Decreased HPV16-GFP infection
- Decreased shRNA abundance (Z-score < -2)
- G0/1 arrest
- Increased G1 DNA content
- Dynamic nuclei (hole, folded or small irregular)
- Decreased HIV-1 infection
- Increased shRNA abundance (Z-score > 2)
- Decreased viability of wild-type and TP53 knockout cells, decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Reduced mammosphere formation
- Decreased viability in esophageal squamous lineage
- Decreased Salmonella enterica Typhimurium invasion
- Decreased Salmonella enterica Typhimurium ruffling
- Decreased Salmonella enterica Typhimurium effector injection
- Decreased viability
- no effect
- Decreased cell number
- Increased vaccinia virus (VACV) infection
- Upregulation of RLR pathway after Sendai virus (SeV) infection
- Decreased hepcidin::fluc mRNA expression
- Increased cell number in S
- shRNA abundance <= 50%
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- FOXO1 nuclear localization
- Lamellipodia cells
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PSMA3
-
CRISPR Products
-
OriGene CRISPR knockouts for PSMA3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PSMA3
- genomics-online: gRNA clones - Search results for available PSMA3 gene related products
- Applied Biological Materials CRISPR for PSMA3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSMA3
- GenScript: Design CRISPR guide RNA sequences for PSMA3
miRNA for PSMA3 Gene
- miRTarBase miRNAs that target PSMA3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PSMA3
- Browse OriGene Inhibitory RNA Products For PSMA3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMA3
- genomics-online: shRNA clones - Search results for available PSMA3 gene related products
Clone Products
- Sino Biological Human cDNA Clone for PSMA3
- VectorBuilder custom plasmid, inducible vectors for PSMA3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PSMA3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PSMA3
- genomics-online: cdna clones - Search results for available PSMA3 gene related products
- orf clones - Search results for available PSMA3 gene related products
- Applied Biological Materials Clones for PSMA3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMA3 Gene
Localization for PSMA3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PSMA3 Gene
- Cytoplasm. Nucleus.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 5 |
| cytoskeleton | 2 |
| mitochondrion | 1 |
- Cytokinetic bridge (2)
- Microtubules (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000502 | proteasome complex | IEA,IDA | 17323924 |
| GO:0005634 | nucleus | TAS | 16130169 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA,TAS | 16130169 |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for PSMA3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | CDK-mediated phosphorylation and removal of Cdc6 |
.93
.93
|
.80
.78
.78
.70
.47
.31
|
| 2 | RET signaling |
.92
|
.92
|
| 3 | Chks in Checkpoint Regulation | ||
| 4 | HIV Life Cycle |
.64
|
.45
|
| 5 | Class I MHC mediated antigen processing and presentation | ||
Pathways by source for PSMA3 Gene
1 Sino Biological pathway for PSMA3 Gene
2 BioSystems pathways for PSMA3 Gene
1 KEGG pathway for PSMA3 Gene
4 GeneGo (Thomson Reuters) pathways for PSMA3 Gene
17 Qiagen pathways for PSMA3 Gene
Interacting Proteins for PSMA3 Gene
Selected Interacting proteins:
P25788-PSA3_HUMAN
ENSP00000216455
for PSMA3 Gene via
UniProtKB
IID
MINT
STRING
GPS-Prot Interaction Network for PSMA3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
| GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
| GO:0006508 | proteolysis | IEA | -- |
No data available for SIGNOR curated interactions for PSMA3 Gene
Drugs & Compounds for PSMA3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Bortezomib | Approved, Investigational | Pharma | inhibitor, other | Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors | 826 | |
| carfilzomib | Approved, Investigational | Pharma | other, Inhibitor | Other, 20S Proteasome Inhibitor | 0 | |
| (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE | Experimental | Pharma | Target | 0 | ||
| Phenethyl isothiocyanate | Investigational | Pharma | Target | 12 |
Transcripts for PSMA3 Gene
mRNA/cDNA for PSMA3 Gene
- (2) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (494) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000216455 970 bps (uc001xdj.3)
- ENST00000412908 908 bps (uc001xdk.3)
- ENST00000553665 925 bps (uc059byj.1)
- ENST00000553677 363 bps (uc059byp.1)
- ENST00000554207 570 bps (uc059byq.1)
Unigene Clusters for PSMA3 Gene
- Proteasome (prosome, macropain) subunit, alpha type, 3:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for PSMA3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PSMA3
- genomics-online: gRNA clones - Search results for available PSMA3 gene related products
- Applied Biological Materials CRISPR for PSMA3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSMA3
- GenScript: Design CRISPR guide RNA sequences for PSMA3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PSMA3
- Browse OriGene Inhibitory RNA Products For PSMA3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMA3
- genomics-online: shRNA clones - Search results for available PSMA3 gene related products
Clone Products
- Sino Biological Human cDNA Clone for PSMA3
- VectorBuilder custom plasmid, inducible vectors for PSMA3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PSMA3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PSMA3
- genomics-online: cdna clones - Search results for available PSMA3 gene related products
- orf clones - Search results for available PSMA3 gene related products
- Applied Biological Materials Clones for PSMA3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||
| SP6: |
Expression for PSMA3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Adipose (Muscoskeletal System)
This gene is overexpressed in Liver, secretome (8.6) and Nasal epithelium (6.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMA3 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of PSMA3 Gene:
PSMA3SOURCE GeneReport for Unigene cluster for PSMA3 Gene:
Hs.558799Evidence on tissue expression from TISSUES for PSMA3 Gene
- Pancreas(4.5)
- Liver(4.4)
- Bone marrow(4.3)
- Blood(4.2)
- Nervous system(3.4)
- Lung(2.8)
- Intestine(2.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for PSMA3
-
OriGene qPCR primer pairs for PSMA3
- genomics-online: primer clones - Search results for available PSMA3 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMA3 Gene
Orthologs for PSMA3 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PSMA3 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | PSMA3 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | PSMA3 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | PSMA3 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Psma3 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Psma3 16 34 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | PSMA3 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PSMA3 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | PSMA3 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | psma3 33 |
|
||
| Str.10919 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | psma3-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | psma3 34 33 |
|
OneToOne | |
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6363 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Prosalpha7 34 35 33 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001973 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | pas-7 34 33 |
|
OneToOne | |
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0A03487g 33 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ADR401C 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PRE10 36 34 33 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | PAG1 33 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.1689 33 |
|
||
| soybean (Glycine max) |
eudicotyledons | Gma.11323 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os01g0811100 33 |
|
||
| Os.3706 33 |
|
||||
| wheat (Triticum aestivum) |
Liliopsida | Ta.14393 33 |
|
||
| barley (Hordeum vulgare) |
Liliopsida | Hv.2915 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.4861 34 |
|
OneToOne | |
| Cin.14529 33 |
|
||||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU02493 33 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | pre10 33 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.14529 33 |
|
- Species where no ortholog for PSMA3 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Evolution for PSMA3 Gene
- ENSEMBL:
- Gene Tree for PSMA3 (if available)
- TreeFam:
- Gene Tree for PSMA3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PSMA3: view image
Paralogs for PSMA3 Gene
(7) SIMAP similar genes for PSMA3 Gene using alignment to 6 proteins:
- PSA3_HUMAN
- G3V3W4_HUMAN
- G3V4X5_HUMAN
- G3V5N4_HUMAN
- H0YJ03_HUMAN
- Q6IB71_HUMAN
Pseudogenes.org Pseudogenes for PSMA3 Gene
No data available for Paralogs for PSMA3 Gene
Variants for PSMA3 Gene
| SNP ID | Clin | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000181071 | -- | 58,246,978(+) | T/C | intron_variant | |
| rs1000215738 | -- | 58,247,312(+) | A/T | intron_variant | |
| rs1000286395 | -- | 58,264,051(+) | C/A | intron_variant | |
| rs1000401813 | -- | 58,270,327(+) | T/C | intron_variant | |
| rs1000610452 | -- | 58,259,100(+) | AAAA/AA | intron_variant |
Residual Variation Intolerance Score:
38.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.12;
2.78% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PSMA3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PSMA3 Gene
Disorders for PSMA3 Gene
Additional Disease Information for PSMA3
No disorders were found for PSMA3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMA3 Gene
Publications for PSMA3 Gene
- Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes). (PMID: 2025653) Tamura T … Ichihara A (Biochimica et biophysica acta 1991) 2 3 4 58
- Crystal structure of the human 20S proteasome in complex with carfilzomib. (PMID: 25599644) Harshbarger W … Sacchettini J (Structure (London, England : 1993) 2015) 3 4 58
- Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production. (PMID: 26524591) Brehm A … Goldbach-Mansky R (The Journal of clinical investigation 2015) 3 4 58
- Ubiquitin-independent degradation of hepatitis C virus F protein. (PMID: 18971267) Yuksek K … Ou JH (Journal of virology 2009) 3 4 58
- Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X … Huang L (Biochemistry 2007) 3 4 58
Products for PSMA3 Gene
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- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for PSMA3
- Search Origene for MassSpec and Protein Over-expression Lysates for PSMA3
- Origene Custom Protein Services for PSMA3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PSMA3
- Browse OriGene Inhibitory RNA Products For PSMA3
- OriGene qPCR primer pairs and template standards for PSMA3
- OriGene qPCR primer pairs for PSMA3
- OriGene CRISPR knockouts for PSMA3
- OriGene ORF clones in human for PSMA3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PSMA3
- GenScript: Next-day shipping of latest version cDNA ORF clones for PSMA3 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for PSMA3
- GenScript Custom Assay Services for PSMA3
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- GenScript: Design CRISPR guide RNA sequences for PSMA3
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for PSMA3
- Sino Biological Human cDNA Clone for PSMA3
- Sino Biological Recombinant Proteins for PSMA3
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- Sino Biological Antibodies for PSMA3
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for PSMA3
- Novus Biologicals proteins and lysates for PSMA3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
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- ProSpec Recombinant Proteins for PSMA3
- VectorBuilder custom plasmid, inducible vectors for PSMA3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PSMA3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 28 available PSMA3 Antibodies ranked by validation data
- Compare Top PSMA3 Antibodies
- antibodies-online: Search results for available PSMA3 related products ranked by validation data
- antibodies-online: Search results for 10 available PSMA3 Proteins ranked by validation data
- Compare Top PSMA3 Proteins
- GeneTex PSMA3 Antibody for PSMA3
- Search GeneTex for Proteins for PSMA3
- Santa Cruz Biotechnology (SCBT) Antibodies for PSMA3
- Search Santa Cruz Biotechnology (SCBT) for PSMA3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PSMA3
- genomics-online: cdna clones - Search results for available PSMA3 gene related products
- orf clones - Search results for available PSMA3 gene related products
- genomics-online: gRNA clones - Search results for available PSMA3 gene related products
- genomics-online: primer clones - Search results for available PSMA3 gene related products
- genomics-online: shRNA clones - Search results for available PSMA3 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PSMA3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PSMA3
- GeneCopoeia miRNA 3'UTR Target clone products for PSMA3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMA3
- Boster Bio Antibodies for PSMA3
- Browse Boster Bio ELISA Kits
Sources for PSMA3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
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- (18) KEGG
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- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
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- (119) Disease Ontology
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- (123) CDC
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- (125) NCBI Bookshelf
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- (133) ENCODE
- (134) ProSci
- (135) Horizon
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- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
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- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt