PSMA3 Gene (Protein Coding)

Proteasome 20S Subunit Alpha 3

GC14P058244
GIFtS:
45
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiq... See more...

Aliases for PSMA3 Gene

Aliases for PSMA3 Gene

  • Proteasome 20S Subunit Alpha 3 2 3 5
  • HC8 2 3 4
  • Proteasome (Prosome, Macropain) Subunit, Alpha Type, 3 2 3
  • Multicatalytic Endopeptidase Complex Subunit C8 3 4
  • Proteasome Subunit Alpha Type-3 3 4
  • Proteasome Subunit Alpha 3 2 3
  • Proteasome Component C8 3 4
  • Macropain Subunit C8 3 4
  • Testicular Secretory Protein Li 43 3
  • Proteasome Subunit Alpha7 3
  • Proteasome Subunit Α7 2
  • Proteasome Subunit C8 3
  • EC 3.4.25.1 51
  • PSMA3 5
  • PSC3 3
  • PSC8 4

External Ids for PSMA3 Gene

Previous GeneCards Identifiers for PSMA3 Gene

  • GC14P056035
  • GC14P052507
  • GC14P056701
  • GC14P057781
  • GC14P058711
  • GC14P038877

Summaries for PSMA3 Gene

Entrez Gene Summary for PSMA3 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for PSMA3 Gene

PSMA3 (Proteasome 20S Subunit Alpha 3) is a Protein Coding gene. Diseases associated with PSMA3 include Proteasome-Associated Autoinflammatory Syndrome 1 and Cystic Fibrosis. Among its related pathways are Downstream signaling events of B Cell Receptor (BCR) and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include endopeptidase activity and threonine-type endopeptidase activity. An important paralog of this gene is PSMA8.

UniProtKB/Swiss-Prot Summary for PSMA3 Gene

  • Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2.

Gene Wiki entry for PSMA3 Gene

Additional gene information for PSMA3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSMA3 Gene

Genomics for PSMA3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for PSMA3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSMA3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PSMA3

Top Transcription factor binding sites by QIAGEN in the PSMA3 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3

Genomic Locations for PSMA3 Gene

Latest Assembly
chr14:58,244,843-58,272,012
(GRCh38/hg38)
Size:
27,170 bases
Orientation:
Plus strand

Previous Assembly
chr14:58,711,561-58,738,722
(GRCh37/hg19 by Entrez Gene)
Size:
27,162 bases
Orientation:
Plus strand

chr14:58,711,549-58,738,730
(GRCh37/hg19 by Ensembl)
Size:
27,182 bases
Orientation:
Plus strand

Genomic View for PSMA3 Gene

Genes around PSMA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMA3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PSMA3 Gene

Proteins for PSMA3 Gene

Products:

  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

  • Protein details for PSMA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25788-PSA3_HUMAN
    Recommended name:
    Proteasome subunit alpha type-3
    Protein Accession:
    P25788
    Secondary Accessions:
    • B2RCK6
    • Q86U83
    • Q8N1D8
    • Q9BS70

    Protein attributes for PSMA3 Gene

    Size:
    255 amino acids
    Molecular mass:
    28433 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. Interacts with AURKB. Interacts with CDKN1A (PubMed:11350925). Interacts with MDM2 and RB1 (PubMed:16337594). Interacts with the C-terminus of TBXA2R isoform 2 (PubMed:17499743). Interacts with DNAJB2 (PubMed:15936278).
    • (Microbial infection) Interacts with HIV-1 Tat protein.
    • (Microbial infection) Interacts with hepatitis C virus (HCV) F protein.
    • (Microbial infection) Interacts with Epstein-Barr virus EBNA3 proteins.

    Three dimensional structures from OCA and Proteopedia for PSMA3 Gene

    Alternative splice isoforms for PSMA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMA3 Gene

Protein Expression for PSMA3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for PSMA3 Gene

P25788:
  • EVAKIIY
  • VHDEVKDK
  • EEAEKYAK
  • KDKAFELE
  • AAKTEIEKL
  • YVHAYTLYSAVRPFG

Post-translational modifications for PSMA3 Gene

  • Ubiquitination at Lys29, Lys57, Lys110, Lys183, and Lys230
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMA3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PSMA3 Gene

Gene Families for PSMA3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PSMA3 Gene

InterPro:
Blocks:
  • Proteasome subunit, A-type
ProtoNet:

Suggested Antigen Peptide Sequences for PSMA3 Gene

GenScript: Design optimal peptide antigens:
  • Proteasome component C8 (PSA3_HUMAN)
  • Proteasome subunit alpha type (Q6IB71_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P25788

UniProtKB/Swiss-Prot:

PSA3_HUMAN :
  • Belongs to the peptidase T1A family.
Family:
  • Belongs to the peptidase T1A family.
genes like me logo Genes that share domains with PSMA3: view

Function for PSMA3 Gene

Products:

  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Molecular function for PSMA3 Gene

UniProtKB/Swiss-Prot Function:
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2.
UniProtKB/Swiss-Prot Induction:
Down-regulated by antioxidants BO-653 and probucol. Up-regulated by bacterial lipopolysaccharides (LPS) and TNF.
GENATLAS Biochemistry:
multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,alpha type 3,subunit HC8

Enzyme Numbers (IUBMB) for PSMA3 Gene

Phenotypes From GWAS Catalog for PSMA3 Gene

Gene Ontology (GO) - Molecular Function for PSMA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IBA 21873635
GO:0005515 protein binding IPI 11146632
GO:0031625 ubiquitin protein ligase binding IPI 16207813
genes like me logo Genes that share ontologies with PSMA3: view
genes like me logo Genes that share phenotypes with PSMA3: view

Animal Models for research

miRNA for PSMA3 Gene

miRTarBase miRNAs that target PSMA3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMA3

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMA3 Gene

Localization for PSMA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMA3 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMA3 gene
Compartment Confidence
cytosol 5
extracellular 4
nucleus 4
cytoskeleton 2
mitochondrion 2
plasma membrane 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PSMA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IEA,IDA 17323924
GO:0005634 nucleus IEA,TAS 16130169
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,TAS 16130169
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PSMA3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PSMA3 Gene

Pathways & Interactions for PSMA3 Gene

PathCards logo

SuperPathways for PSMA3 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
Activation of APC/C and APC/C-Cdc20 mediated degradation of mitotic proteins
.95
Cdc20-Phospho-APC/C mediated degradation of Cyclin A
.95
Autodegradation of the E3 ubiquitin ligase COP1
.95
Stabilization of p53
.95
Regulation of activated PAK-2p34 by proteasome mediated degradation
.94
Regulation of Apoptosis
.94
CDK-mediated phosphorylation and removal of Cdc6
.94
Ubiquitin-dependent degradation of Cyclin D
.94
Ubiquitin-dependent degradation of Cyclin D1
.94
Orc1 removal from chromatin
.94
Regulation of DNA replication
.94
Switching of origins to a post-replicative state
.94
Cyclin A-Cdk2-associated events at S phase entry
.93
Cyclin E associated events during G1/S transition
.93
APC/C-Cdc20 mediated degradation of Securin
.93
APC/C-Cdh1 mediated degradation of Cdc20 and other APC/C-Cdh1 targeted proteins in late mitosis/early G1
.93
APC/C-mediated degradation of cell cycle proteins
.93
Regulation of APC/C activators between G1/S and early anaphase
.93
Regulation of mitotic cell cycle
.93
DNA Replication
.93
Synthesis of DNA
.93
Vpu mediated degradation of CD4
.93
Autodegradation of Cdh1 by Cdh1-APC/C
.91
SCF-beta-TrCP mediated degradation of Emi1
.91
p53-Independent DNA Damage Response
.91
p53-Independent G1/S DNA damage checkpoint
.91
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
.91
ABC transporter disorders
.91
Disorders of transmembrane transporters
.91
Defective CFTR causes cystic fibrosis
.90
Assembly of the pre-replicative complex
.90
Hedgehog ligand biogenesis
.90
Hh mutants abrogate ligand secretion
.90
APC/C-Cdc20 mediated degradation of mitotic proteins
.89
APC-Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
.89
Vif-mediated degradation of APOBEC3G
.89
Degradation of GLI1 by the proteasome
.89
Degradation of GLI2 by the proteasome
.89
GLI3 is processed to GLI3R by the proteasome
.89
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
.88
Degradation of AXIN
.88
Cellular response to hypoxia
.87
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
.87
Regulation of Hypoxia-inducible Factor (HIF) by oxygen
.87
CDT1 association with the CDC6-ORC-origin complex
.87
Hh mutants that dont undergo autocatalytic processing are degraded by ERAD
.87
AUF1 (hnRNP D0) binds and destabilizes mRNA
.86
p53-Dependent G1 DNA Damage Response
.86
p53-Dependent G1/S DNA damage checkpoint
.86
SCF(Skp2)-mediated degradation of p27/p21
.86
Removal of licensing factors from origins
.86
NIK-->noncanonical NF-kB signaling
.85
Dectin-1 mediated noncanonical NF-kB signaling
.84
G1/S DNA Damage Checkpoints
.84
Degradation of DVL
.83
Cross-presentation of soluble exogenous antigens (endosomes)
.82
The role of GTSE1 in G2/M progression after G2 checkpoint
.81
Regulation of ornithine decarboxylase (ODC)
.81
DNA Replication Pre-Initiation
.80
M/G1 Transition
.80
Proteasome
.80
S Phase
.78
Activation of NF-kappaB in B cells
.77
Asymmetric localization of PCP proteins
.74
FCERI mediated NF-kB activation
.72
Regulation of RAS by GAPs
.70
PCP/CE pathway
.70
Beta-catenin independent WNT signaling
.64
Degradation of beta-catenin by the destruction complex
.64
Regulation of mRNA stability by proteins that bind AU-rich elements
.63
Metabolism of polyamines
.60
ABC-family proteins mediated transport
.58
TNFR2 non-canonical NF-kB pathway
.58
MAPK6/MAPK4 signaling
.57
Proteasome Degradation
.56
UCH proteinases
.47
Canonical Wnt Pathway
.31
Apoptosis
.31
Programmed Cell Death
.31
2 RET signaling
Frs2-mediated activation
.95
GRB2 events in EGFR signaling
.95
MAPK1/MAPK3 signaling
.95
Prolonged ERK activation events
.95
RAF/MAP kinase cascade
.95
SHC1 events in EGFR signaling
.95
Signaling by Leptin
.95
SOS-mediated signalling
.95
VEGFR2 mediated cell proliferation
.95
ARMS-mediated activation
.95
Signalling to ERKs
.95
Signalling to p38 via RIT and RIN
.95
Signalling to RAS
.95
Interleukin receptor SHC signaling
.95
Interleukin-3, 5 and GM-CSF signaling
.94
Interleukin-2 signaling
.94
Downstream signal transduction
.94
Signaling by PDGF
.94
DAP12 signaling
.92
RET signaling
.92
Insulin receptor signalling cascade
.92
Signaling by Insulin receptor
.92
IRS-mediated signalling
.91
Signaling by EGFR
.90
FCERI mediated MAPK activation
.90
IGF1R signaling cascade
.90
IRS-related events triggered by IGF1R
.90
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
.90
DAP12 interactions
.89
NCAM signaling for neurite out-growth
.89
NGF signalling via TRKA from the plasma membrane
.87
MAPK family signaling cascades
.87
Signaling by SCF-KIT
.85
Signalling by NGF
.81
Fc epsilon receptor (FCERI) signaling
.79
VEGFA-VEGFR2 Pathway
.78
Signaling by VEGF
.76
Gastrin-CREB signalling pathway via PKC and MAPK
.55
3 Chks in Checkpoint Regulation
Chks in Checkpoint Regulation
.59
G2-M Phase Transition
.59
Estrogen-mediated S-Phase Entry
.55
SREBP Proteolysis
.43
DNA Repair Mechanisms
.32
Parkinson's Disease Pathway
.31
4 HIV Life Cycle
HIV Infection
.64
Infectious disease
.61
Host Interactions of HIV factors
.57
Disease
.45
Diseases of signal transduction
.43
5 Pathways of neurodegeneration - multiple diseases
Alzheimer disease
.65
Pathways of neurodegeneration - multiple diseases
.65
Amyotrophic lateral sclerosis
.54
Huntington disease
.50
genes like me logo Genes that share pathways with PSMA3: view

Pathways by source for PSMA3 Gene

1 Sino Biological pathway for PSMA3 Gene
2 BioSystems pathways for PSMA3 Gene
4 GeneGo (Thomson Reuters) pathways for PSMA3 Gene
  • Immune response Antigen presentation by MHC class I
  • Regulation of degradation of deltaF508 CFTR in CF
  • Regulation of degradation of wt-CFTR
  • Transcription Ligand-Dependent Transcription of Retinoid-Target genes
17 Qiagen pathways for PSMA3 Gene
  • CDK5 Pathway
  • Chks in Checkpoint Regulation
  • DNA Repair Mechanisms
  • Estrogen-mediated S-Phase Entry
  • G2-M Phase Transition

SIGNOR curated interactions for PSMA3 Gene

Other effect:

Gene Ontology (GO) - Biological Process for PSMA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
genes like me logo Genes that share ontologies with PSMA3: view

Drugs & Compounds for PSMA3 Gene

Products:

  1. Drug products for research

(4) Drugs for PSMA3 Gene - From: DrugBank and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 926
carfilzomib Approved, Investigational Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Experimental Pharma Target 0
Phenethyl isothiocyanate Investigational Pharma Target 12
genes like me logo Genes that share compounds with PSMA3: view

Transcripts for PSMA3 Gene

Products:

  1. CRISPR products for research
  2. miRNA products for research
  3. Inhibitory RNAs for research
  4. Clone products for research

mRNA/cDNA for PSMA3 Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMA3

Alternative Splicing Database (ASD) splice patterns (SP) for PSMA3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12
SP1: -
SP2: - -
SP3: - -
SP4: -
SP5:
SP6:

Relevant External Links for PSMA3 Gene

GeneLoc Exon Structure for
PSMA3

Expression for PSMA3 Gene

Products:

  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PSMA3 Gene

mRNA expression in normal human tissues for PSMA3 Gene
mRNA expression by BioGPS for PSMA3 GenemRNA expression by GTEx for PSMA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PSMA3 Gene

This gene is overexpressed in Liver, secretome (8.6) and Nasal epithelium (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMA3 Gene



Protein tissue co-expression partners for PSMA3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PSMA3

SOURCE GeneReport for Unigene cluster for PSMA3 Gene:

Hs.558799

Evidence on tissue expression from TISSUES for PSMA3 Gene

  • Liver(4.5)
  • Pancreas(4.5)
  • Bone marrow(4.4)
  • Blood(4.4)
  • Nervous system(3.8)
  • Lung(3.1)
  • Intestine(2.7)
  • Skin(2.5)
  • Lymph node(2.3)
  • Kidney(2.3)
  • Muscle(2.3)
  • Heart(2.3)
  • Spleen(2.2)
genes like me logo Genes that share expression patterns with PSMA3: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMA3 Gene

Orthologs for PSMA3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMA3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia PSMA3 30 31
  • 99.74 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia PSMA3 31
  • 98 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia PSMA3 30 31
  • 94.64 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia PSMA3 30 31
  • 93.86 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Psma3 30
  • 93.2 (n)
Mouse
(Mus musculus)
 Mammalia Psma3 30 17 31
  • 92.03 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia PSMA3 31
  • 87 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves PSMA3 30 31
  • 85.1 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia PSMA3 31
  • 95 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia psma3 30
  • 78.95 (n)
Str.10919 30
African clawed frog
(Xenopus laevis)
 Amphibia psma3-prov 30
Zebrafish
(Danio rerio)
 Actinopterygii psma3 30 31
  • 77.65 (n)
 OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.6363 30
Fruit Fly
(Drosophila melanogaster)
 Insecta Prosalpha7 30 31 32
  • 58.57 (n)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP001973 30
  • 57.64 (n)
Worm
(Caenorhabditis elegans)
 Secernentea pas-7 30 31
  • 56 (n)
 OneToOne
K. Lactis Yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0A03487g 30
  • 57.84 (n)
A. gosspyii yeast
(Eremothecium gossypii)
 Saccharomycetes AGOS_ADR401C 30
  • 56.13 (n)
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes PRE10 30 31 33
  • 56.04 (n)
 OneToOne
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons PAG1 30
  • 60.59 (n)
Alicante grape
(Vitis vinifera)
 eudicotyledons Vvi.1689 30
Soybean
(Glycine max)
 eudicotyledons Gma.11323 30
Rice
(Oryza sativa)
 Liliopsida Os01g0811100 30
  • 62.08 (n)
Os.3706 30
Barley
(Hordeum vulgare)
 Liliopsida Hv.2915 30
Wheat
(Triticum aestivum)
 Liliopsida Ta.14393 30
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.4861 31
  • 66 (a)
 OneToOne
Bread mold
(Neurospora crassa)
 Ascomycetes NCU02493 30
  • 56.8 (n)
Fission Yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes pre10 30
  • 54.79 (n)
Sea Vase
(Ciona intestinalis)
 Ascidiacea Cin.14529 30
Species where no ortholog for PSMA3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMA3 Gene

ENSEMBL:
Gene Tree for PSMA3 (if available)
TreeFam:
Gene Tree for PSMA3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PSMA3: view image

Paralogs for PSMA3 Gene

Paralogs for PSMA3 Gene

(7) SIMAP similar genes for PSMA3 Gene using alignment to 6 proteins:

  • PSA3_HUMAN
  • G3V3W4_HUMAN
  • G3V4X5_HUMAN
  • G3V5N4_HUMAN
  • H0YJ03_HUMAN
  • Q6IB71_HUMAN

Pseudogenes.org Pseudogenes for PSMA3 Gene

genes like me logo Genes that share paralogs with PSMA3: view

Variants for PSMA3 Gene

Products:

  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PSMA3 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs1555352516 Pathogenic: PROTEASOME-ASSOCIATED AUTOINFLAMMATORY SYNDROME 1, DIGENIC 58,258,000(+) T/C
NM_002788.4(PSMA3):c.404+2T>C 		SPLICE_DONOR
rs1555353410 Pathogenic: PROTEASOME-ASSOCIATED AUTOINFLAMMATORY SYNDROME 1, DIGENIC 58,270,970(+) TAAG/T
NM_002788.4(PSMA3):c.697_699del (p.Arg233del) 		NON_CODING_TRANSCRIPT_VARIANT,INFRAME_DELETION

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PSMA3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for PSMA3 Gene

Residual Variation Intolerance Score: 38.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PSMA3 Gene

Human Gene Mutation Database (HGMD)
PSMA3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMA3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PSMA3 Gene

Disorders for PSMA3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PSMA3 Gene - From: COP and GCD

- elite association - COSMIC cancer census association via MalaCards
Search PSMA3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PSMA3

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PSMA3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSMA3 Gene

Publications for PSMA3 Gene

  1. Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes). (PMID: 2025653) Tamura T … Ichihara A (Biochimica et biophysica acta 1991) 2 3 4
  2. An atomic structure of the human 26S proteasome. (PMID: 27428775) Huang X … Shi Y (Nature structural & molecular biology 2016) 3 4
  3. Crystal structure of the human 20S proteasome in complex with carfilzomib. (PMID: 25599644) Harshbarger W … Sacchettini J (Structure (London, England : 1993) 2015) 3 4
  4. Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production. (PMID: 26524591) Brehm A … Goldbach-Mansky R (The Journal of clinical investigation 2015) 3 4
  5. Ubiquitin-independent degradation of hepatitis C virus F protein. (PMID: 18971267) Yuksek K … Ou JH (Journal of virology 2009) 3 4

ExternalLinks

View latest publications for PSMA3 gene in Mastermind

Products for PSMA3 Gene