Free for academic non-profit institutions. Other users need a Commercial license

PSMA3 Gene(Protein Coding)

Proteasome Subunit Alpha 3

GCID:
GC14P058244
GIFtS:
47
Genes Participants
UDN Logo

Aliases for PSMA3 Gene

Aliases for PSMA3 Gene

  • Proteasome Subunit Alpha 3 2 3 5
  • Proteasome (Prosome, Macropain) Subunit, Alpha Type, 3 2 3
  • Multicatalytic Endopeptidase Complex Subunit C8 3 4
  • Proteasome Component C8 3 4
  • Macropain Subunit C8 3 4
  • HC8 3 4
  • Testicular Secretory Protein Li 43 3
  • Proteasome Subunit Alpha Type-3 3
  • Proteasome Subunit C8 3
  • EC 3.4.25.1 4
  • PSC3 3
  • PSC8 4

External Ids for PSMA3 Gene

Previous GeneCards Identifiers for PSMA3 Gene

  • GC14P056035
  • GC14P052507
  • GC14P056701
  • GC14P057781
  • GC14P058711
  • GC14P038877

Summaries for PSMA3 Gene

Entrez Gene Summary for PSMA3 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for PSMA3 Gene

PSMA3 (Proteasome Subunit Alpha 3) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and RET signaling. Gene Ontology (GO) annotations related to this gene include endopeptidase activity and threonine-type endopeptidase activity.

UniProtKB/Swiss-Prot for PSMA3 Gene

  • Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2.

Gene Wiki entry for PSMA3 Gene

Additional gene information for PSMA3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMA3 Gene

Genomics for PSMA3 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for PSMA3 Gene

Promoters and enhancers for PSMA3 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH14J058242 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 650.7 -0.2 -200 3.6 HDGF PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B PSMA3 RNU6-341P ARID4A ARMH4 PSMA3-AS1 ENSG00000258682 TRK-CTT1-1 GC14P058110
GH14J058271 Enhancer 1.1 ENCODE dbSUPER 0.3 +27.8 27822 2 FOXA2 MLX ARID4B DMAP1 YY1 PAF1 RXRA REST PPARG KAT8 PIR55001 KIAA0586 ENSG00000258682 HMGB1P14 ARMH4 PSMA3 PSMA3-AS1
GH14J058260 Enhancer 0.2 FANTOM5 0.4 +15.6 15615 0.6 RNU6-341P TOMM20L ENSG00000258682 PSMA3 ARMH4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSMA3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PSMA3 gene promoter:
  • AP-1
  • c-Jun
  • ATF-2
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3

Genomic Locations for PSMA3 Gene

Genomic Locations for PSMA3 Gene
chr14:58,244,805-58,272,012
(GRCh38/hg38)
Size:
27,208 bases
Orientation:
Plus strand
chr14:58,711,523-58,738,730
(GRCh37/hg19)
Size:
27,208 bases
Orientation:
Plus strand

Genomic View for PSMA3 Gene

Genes around PSMA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMA3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PSMA3 Gene

Proteins for PSMA3 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for PSMA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25788-PSA3_HUMAN
    Recommended name:
    Proteasome subunit alpha type-3
    Protein Accession:
    P25788
    Secondary Accessions:
    • B2RCK6
    • Q86U83
    • Q8N1D8
    • Q9BS70

    Protein attributes for PSMA3 Gene

    Size:
    255 amino acids
    Molecular mass:
    28433 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. Interacts with AURKB. Interacts with CDKN1A (PubMed:11350925). Interacts with HIV-1 TAT protein (PubMed:14550573). Interacts with hepatitis C virus (HCV) F protein (PubMed:18971267). Interacts with Epstein-Barr virus EBNA3 proteins (PubMed:15831937). Interacts with MDM2 and RB1 (PubMed:16337594). Interacts with the C-terminus of TBXA2R isoform 2 (PubMed:17499743). Interacts with DNAJB2 (PubMed:15936278).

    Three dimensional structures from OCA and Proteopedia for PSMA3 Gene

    Alternative splice isoforms for PSMA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMA3 Gene

Protein Expression for PSMA3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for PSMA3 Gene

  • Ubiquitination at posLast=230230, Lys183, Lys110, posLast=5757, and Lys29
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMA3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PSMA3 Gene

Domains & Families for PSMA3 Gene

Gene Families for PSMA3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PSMA3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PSMA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P25788

UniProtKB/Swiss-Prot:

PSA3_HUMAN :
  • Belongs to the peptidase T1A family.
Family:
  • Belongs to the peptidase T1A family.
genes like me logo Genes that share domains with PSMA3: view

Function for PSMA3 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for PSMA3 Gene

UniProtKB/Swiss-Prot Function:
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2.
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of peptide bonds with very broad specificity.
UniProtKB/Swiss-Prot Induction:
Down-regulated by antioxidants BO-653 and probucol. Up-regulated by bacterial lipopolysaccharides (LPS) and TNF.
GENATLAS Biochemistry:
multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,alpha type 3,subunit HC8

Enzyme Numbers (IUBMB) for PSMA3 Gene

Phenotypes From GWAS Catalog for PSMA3 Gene

Gene Ontology (GO) - Molecular Function for PSMA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IEA,IBA --
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 11146632
GO:0008233 peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PSMA3: view
genes like me logo Genes that share phenotypes with PSMA3: view

Animal Model Products

CRISPR Products

miRNA for PSMA3 Gene

miRTarBase miRNAs that target PSMA3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMA3

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMA3 Gene

Localization for PSMA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMA3 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMA3 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
cytoskeleton 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (2)
  • Microtubules (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PSMA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IEA,IDA 17323924
GO:0005634 nucleus TAS 16130169
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,TAS 16130169
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PSMA3: view

Pathways & Interactions for PSMA3 Gene

SuperPathways for PSMA3 Gene

PathCards logo More details on SuperPathways for PSMA3
SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
Activation of APC/C and APC/C-Cdc20 mediated degradation of mitotic proteins
.95
Cdc20-Phospho-APC/C mediated degradation of Cyclin A
.95
Autodegradation of the E3 ubiquitin ligase COP1
.95
Stabilization of p53
.95
Regulation of activated PAK-2p34 by proteasome mediated degradation
.94
Regulation of Apoptosis
.94
CDK-mediated phosphorylation and removal of Cdc6
.94
Ubiquitin-dependent degradation of Cyclin D
.94
Ubiquitin-dependent degradation of Cyclin D1
.94
Orc1 removal from chromatin
.94
Regulation of DNA replication
.94
Switching of origins to a post-replicative state
.94
Cyclin A-Cdk2-associated events at S phase entry
.93
Cyclin E associated events during G1/S transition
.93
APC/C-Cdc20 mediated degradation of Securin
.93
APC/C-Cdh1 mediated degradation of Cdc20 and other APC/C-Cdh1 targeted proteins in late mitosis/early G1
.93
APC/C-mediated degradation of cell cycle proteins
.93
Regulation of APC/C activators between G1/S and early anaphase
.93
Regulation of mitotic cell cycle
.93
DNA Replication
.93
Synthesis of DNA
.93
Vpu mediated degradation of CD4
.93
Autodegradation of Cdh1 by Cdh1-APC/C
.91
SCF-beta-TrCP mediated degradation of Emi1
.91
p53-Independent DNA Damage Response
.91
p53-Independent G1/S DNA damage checkpoint
.91
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
.91
ABC transporter disorders
.91
Disorders of transmembrane transporters
.91
Defective CFTR causes cystic fibrosis
.90
Assembly of the pre-replicative complex
.90
Hedgehog ligand biogenesis
.90
Hh mutants abrogate ligand secretion
.90
APC/C-Cdc20 mediated degradation of mitotic proteins
.89
APC-Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
.89
Vif-mediated degradation of APOBEC3G
.89
Degradation of GLI1 by the proteasome
.89
Degradation of GLI2 by the proteasome
.89
GLI3 is processed to GLI3R by the proteasome
.89
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
.88
Degradation of AXIN
.88
Cellular response to hypoxia
.87
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
.87
Regulation of Hypoxia-inducible Factor (HIF) by oxygen
.87
CDT1 association with the CDC6-ORC-origin complex
.87
Hh mutants that dont undergo autocatalytic processing are degraded by ERAD
.87
AUF1 (hnRNP D0) binds and destabilizes mRNA
.86
p53-Dependent G1 DNA Damage Response
.86
p53-Dependent G1/S DNA damage checkpoint
.86
SCF(Skp2)-mediated degradation of p27/p21
.86
Removal of licensing factors from origins
.86
NIK-->noncanonical NF-kB signaling
.85
Dectin-1 mediated noncanonical NF-kB signaling
.84
G1/S DNA Damage Checkpoints
.84
Degradation of DVL
.83
Cross-presentation of soluble exogenous antigens (endosomes)
.82
The role of GTSE1 in G2/M progression after G2 checkpoint
.81
Regulation of ornithine decarboxylase (ODC)
.81
DNA Replication Pre-Initiation
.80
M/G1 Transition
.80
Proteasome
.78
S Phase
.78
Activation of NF-kappaB in B cells
.77
Asymmetric localization of PCP proteins
.74
FCERI mediated NF-kB activation
.72
Regulation of RAS by GAPs
.70
PCP/CE pathway
.70
Beta-catenin independent WNT signaling
.64
Degradation of beta-catenin by the destruction complex
.64
Regulation of mRNA stability by proteins that bind AU-rich elements
.63
Metabolism of polyamines
.60
TNFR2 non-canonical NF-kB pathway
.58
ABC-family proteins mediated transport
.57
MAPK6/MAPK4 signaling
.57
Proteasome Degradation
.56
UCH proteinases
.47
Canonical Wnt Pathway
.32
Apoptosis
.31
Programmed Cell Death
.31
2 RET signaling
Frs2-mediated activation
.95
GRB2 events in EGFR signaling
.95
MAPK1/MAPK3 signaling
.95
Prolonged ERK activation events
.95
RAF/MAP kinase cascade
.95
SHC1 events in EGFR signaling
.95
Signaling by Leptin
.95
SOS-mediated signalling
.95
VEGFR2 mediated cell proliferation
.95
ARMS-mediated activation
.95
Signalling to ERKs
.95
Signalling to p38 via RIT and RIN
.95
Signalling to RAS
.95
Interleukin receptor SHC signaling
.95
Interleukin-3, 5 and GM-CSF signaling
.94
Interleukin-2 signaling
.94
Downstream signal transduction
.94
Signaling by PDGF
.94
DAP12 signaling
.92
RET signaling
.92
Insulin receptor signalling cascade
.92
Signaling by Insulin receptor
.92
IRS-mediated signalling
.91
Signaling by EGFR
.90
FCERI mediated MAPK activation
.90
IGF1R signaling cascade
.90
IRS-related events triggered by IGF1R
.90
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
.90
DAP12 interactions
.89
NCAM signaling for neurite out-growth
.89
NGF signalling via TRKA from the plasma membrane
.87
MAPK family signaling cascades
.87
Signaling by SCF-KIT
.85
Signalling by NGF
.81
Fc epsilon receptor (FCERI) signaling
.79
VEGFA-VEGFR2 Pathway
.78
Signaling by VEGF
.76
Gastrin-CREB signalling pathway via PKC and MAPK
.55
3 Chks in Checkpoint Regulation
Chks in Checkpoint Regulation
.59
G2-M Phase Transition
.59
Estrogen-mediated S-Phase Entry
.55
SREBP Proteolysis
.43
DNA Repair Mechanisms
.32
Parkinson's Disease Pathway
.31
4 HIV Life Cycle
HIV Infection
.64
Infectious disease
.61
Host Interactions of HIV factors
.57
Disease
.45
Diseases of signal transduction
.43
5 Class I MHC mediated antigen processing and presentation
Antigen processing- Ubiquitination and Proteasome degradation
.83
Class I MHC mediated antigen processing and presentation
.83
Adaptive Immune System
.45
genes like me logo Genes that share pathways with PSMA3: view

Gene Ontology (GO) - Biological Process for PSMA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PSMA3: view

No data available for SIGNOR curated interactions for PSMA3 Gene

Drugs & Compounds for PSMA3 Gene

Products:

  1. Drug

(4) Drugs for PSMA3 Gene - From: DrugBank and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 826
carfilzomib Approved, Investigational Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Experimental Pharma Target 0
Phenethyl isothiocyanate Investigational Pharma Target 12
genes like me logo Genes that share compounds with PSMA3: view

Transcripts for PSMA3 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for PSMA3 Gene

(2) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(494) Selected AceView cDNA sequences:
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PSMA3 Gene

Proteasome (prosome, macropain) subunit, alpha type, 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMA3

Alternative Splicing Database (ASD) splice patterns (SP) for PSMA3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12
SP1: -
SP2: - -
SP3: - -
SP4: -
SP5:
SP6:

Relevant External Links for PSMA3 Gene

GeneLoc Exon Structure for
PSMA3
ECgene alternative splicing isoforms for
PSMA3

Expression for PSMA3 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSMA3 Gene

mRNA expression in normal human tissues for PSMA3 Gene
mRNA expression by BioGPS for PSMA3 GenemRNA expression by GTEx for PSMA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PSMA3 Gene

This gene is overexpressed in Liver, secretome (8.6) and Nasal epithelium (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMA3 Gene



Protein tissue co-expression partners for PSMA3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PSMA3 Gene:

PSMA3

SOURCE GeneReport for Unigene cluster for PSMA3 Gene:

Hs.558799

Evidence on tissue expression from TISSUES for PSMA3 Gene

  • Pancreas(4.5)
  • Liver(4.4)
  • Bone marrow(4.3)
  • Blood(4.2)
  • Nervous system(3.4)
  • Lung(2.8)
  • Intestine(2.2)
genes like me logo Genes that share expression patterns with PSMA3: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMA3 Gene

Orthologs for PSMA3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia PSMA3 34 33
  • 99.74 (n)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia PSMA3 34
  • 98 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia PSMA3 34 33
  • 94.64 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia PSMA3 34 33
  • 93.86 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Psma3 33
  • 93.2 (n)
mouse
(Mus musculus)
 Mammalia Psma3 16 34 33
  • 92.03 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia PSMA3 34
  • 87 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves PSMA3 34 33
  • 85.1 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia PSMA3 34
  • 95 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia psma3 33
  • 78.95 (n)
Str.10919 33
African clawed frog
(Xenopus laevis)
 Amphibia psma3-prov 33
zebrafish
(Danio rerio)
 Actinopterygii psma3 34 33
  • 77.65 (n)
 OneToOne
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.6363 33
fruit fly
(Drosophila melanogaster)
 Insecta Prosalpha7 34 35 33
  • 58.57 (n)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP001973 33
  • 57.64 (n)
worm
(Caenorhabditis elegans)
 Secernentea pas-7 34 33
  • 56 (n)
 OneToOne
K. lactis yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0A03487g 33
  • 57.84 (n)
A. gosspyii yeast
(Ashbya gossypii)
 Saccharomycetes AGOS_ADR401C 33
  • 56.13 (n)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes PRE10 36 34 33
  • 56.04 (n)
thale cress
(Arabidopsis thaliana)
 eudicotyledons PAG1 33
  • 60.59 (n)
Alicante grape
(Vitis vinifera)
 eudicotyledons Vvi.1689 33
soybean
(Glycine max)
 eudicotyledons Gma.11323 33
rice
(Oryza sativa)
 Liliopsida Os01g0811100 33
  • 62.08 (n)
Os.3706 33
wheat
(Triticum aestivum)
 Liliopsida Ta.14393 33
barley
(Hordeum vulgare)
 Liliopsida Hv.2915 33
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.4861 34
  • 66 (a)
 OneToOne
Cin.14529 33
bread mold
(Neurospora crassa)
 Ascomycetes NCU02493 33
  • 56.8 (n)
fission yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes pre10 33
  • 54.79 (n)
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.14529 33
Species where no ortholog for PSMA3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMA3 Gene

ENSEMBL:
Gene Tree for PSMA3 (if available)
TreeFam:
Gene Tree for PSMA3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PSMA3: view image

Paralogs for PSMA3 Gene

(7) SIMAP similar genes for PSMA3 Gene using alignment to 6 proteins:

  • PSA3_HUMAN
  • G3V3W4_HUMAN
  • G3V4X5_HUMAN
  • G3V5N4_HUMAN
  • H0YJ03_HUMAN
  • Q6IB71_HUMAN

Pseudogenes.org Pseudogenes for PSMA3 Gene

genes like me logo Genes that share paralogs with PSMA3: view

No data available for Paralogs for PSMA3 Gene

Variants for PSMA3 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for PSMA3 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000181071 -- 58,246,978(+) T/C intron_variant
rs1000215738 -- 58,247,312(+) A/T intron_variant
rs1000286395 -- 58,264,051(+) C/A intron_variant
rs1000401813 -- 58,270,327(+) T/C intron_variant
rs1000610452 -- 58,259,100(+) AAAA/AA intron_variant

Variation tolerance for PSMA3 Gene

Residual Variation Intolerance Score: 38.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PSMA3 Gene

Human Gene Mutation Database (HGMD)
PSMA3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMA3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PSMA3 Gene

Disorders for PSMA3 Gene

Additional Disease Information for PSMA3

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PSMA3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMA3 Gene

Publications for PSMA3 Gene

  1. Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes). (PMID: 2025653) Tamura T … Ichihara A (Biochimica et biophysica acta 1991) 2 3 4 58
  2. Crystal structure of the human 20S proteasome in complex with carfilzomib. (PMID: 25599644) Harshbarger W … Sacchettini J (Structure (London, England : 1993) 2015) 3 4 58
  3. Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production. (PMID: 26524591) Brehm A … Goldbach-Mansky R (The Journal of clinical investigation 2015) 3 4 58
  4. Ubiquitin-independent degradation of hepatitis C virus F protein. (PMID: 18971267) Yuksek K … Ou JH (Journal of virology 2009) 3 4 58
  5. Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X … Huang L (Biochemistry 2007) 3 4 58

Products for PSMA3 Gene

Sources for PSMA3 Gene

Content
Loading form....