Aliases for PSMA2 Gene
Aliases for PSMA2 Gene
External Ids for PSMA2 Gene
- HGNC: 9531
- Entrez Gene: 5683
- Ensembl: ENSG00000106588
- OMIM: 176842
- UniProtKB: P25787
Previous GeneCards Identifiers for PSMA2 Gene
- GC07M042603
- GC07M042663
- GC07M042697
- GC07M042729
- GC07M042922
- GC07M042841
- GC07M042956
Summaries for PSMA2 Gene
-
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. [provided by RefSeq, Jul 2008]
GeneCards Summary for PSMA2 Gene
PSMA2 (Proteasome Subunit Alpha 2) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and RET signaling. Gene Ontology (GO) annotations related to this gene include endopeptidase activity and threonine-type endopeptidase activity. An important paralog of this gene is ENSG00000256646.
UniProtKB/Swiss-Prot for PSMA2 Gene
-
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
Additional gene information for PSMA2 Gene
- Monarch Initiative
- Search for PSMA2 at DataMed
- Search for PSMA2 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMA2 Gene
Genomics for PSMA2 Gene
GeneHancer (GH) Regulatory Elements for PSMA2 Gene
Promoters and enhancers for PSMA2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around PSMA2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PSMA2 gene promoter:
-
- AML1a
- MEF-2A
- aMEF-2
- AP-2rep
- FOXL1
- AREB6
- CUTL1
- Pax-3
- FAC1
- PPAR-gamma2
Regulatory Element Products
Genomic Locations for PSMA2 Gene
Genomic Locations for PSMA2 Gene
- chr7:42,916,857-42,932,223
- (GRCh38/hg38)
- Size:
- 15,367 bases
- Orientation:
- Minus strand
- chr7:42,956,460-42,971,822
- (GRCh37/hg19)
- Size:
- 15,363 bases
- Orientation:
- Minus strand
Genomic View for PSMA2 Gene
Genes around PSMA2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7p14.1 by Entrez Gene
- 7p14.1 by HGNC
- 7p14.1 by Ensembl
PSMA2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PSMA2 Gene
Proteins for PSMA2 Gene
-
Protein details for PSMA2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P25787-PSA2_HUMAN
- Recommended name:
- Proteasome subunit alpha type-2
- Protein Accession:
- P25787
- Q6ICS6
- Q9BU45
Protein attributes for PSMA2 Gene
- Size:
- 234 amino acids
- Molecular mass:
- 25899 Da
- Quaternary structure:
-
- The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.
Protein Expression for PSMA2 Gene
Post-translational modifications for PSMA2 Gene
- Phosphorylated on tyrosine residues; which may be important for nuclear import.
- Ubiquitination at posLast=171171, posLast=165165, Lys92, Lys70, posLast=5353, and posLast=3939
- Modification sites at PhosphoSitePlus
Other Protein References for PSMA2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for PSMA2 (PSMA2)
- Novus Biologicals Antibodies for PSMA2
-
Abcam antibodies for PSMA2
- Invitrogen Antibodies for PSMA2
- GeneTex PSMA2 Antibody for PSMA2
-
Santa Cruz Biotechnology (SCBT) Antibodies for PSMA2
Protein Products
-
OriGene Purified Proteins for PSMA2
- Search Origene for MassSpec and Protein Over-expression Lysates for PSMA2
- Origene Custom Protein Services for PSMA2
- ProSpec Recombinant Proteins for PSMA2
- Search GeneTex for Proteins for PSMA2
-
Abcam proteins for PSMA2
Assay Products
- R&D Systems ELISAs and other biochemical assays for PSMA2 (PSMA2)
- antibodies-online: Search results for 1 available PSMA2 Elisa Kits ranked by validation data
- Compare Top PSMA2 Elisa Kits
-
Recommended
No data available for DME Specific Peptides for PSMA2 Gene
Domains & Families for PSMA2 Gene
Gene Families for PSMA2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for PSMA2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PSMA2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P25787- Family:
-
- Belongs to the peptidase T1A family.
Function for PSMA2 Gene
Molecular function for PSMA2 Gene
- UniProtKB/Swiss-Prot Function:
- Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Cleavage of peptide bonds with very broad specificity.
- UniProtKB/Swiss-Prot Induction:
- Down-regulated by antioxidants BO-653 and probucol. Down-regulated in response to enterovirus 71 (EV71) infection (at protein level).
- GENATLAS Biochemistry:
- multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,alpha type 2,subunit HC3,25.9 kDa,would be localized in 7p13-p12 (Trachtulec)
Enzyme Numbers (IUBMB) for PSMA2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004175 | endopeptidase activity | IEA,IBA | -- |
| GO:0004298 | threonine-type endopeptidase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 12376572 |
| GO:0008233 | peptidase activity | IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for PSMA2 Gene
- GenomeRNAi human phenotypes for PSMA2:
-
- Decreased shRNA abundance (Z-score < -2)
- Dynamic nuclei (hole, folded or small irregular)
- Increased shRNA abundance (Z-score > 2)
- Decreased HIV-1 infection
- Decreased homologous recombination repair frequency
- Decreased viability of wild-type and TP53 knockout cells, decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Reduced mammosphere formation
- Decreased viability in esophageal squamous lineage
- Decreased shRNA abundance
- Decreased viability
- no effect
- Decreased cell number
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- shRNA abundance <= 50%
- FOXO1 nuclear localization
- HIV Rev nuclear localization
- Synthetic lethal with vaccinia virus (VACV) infection
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PSMA2
-
CRISPR Products
-
OriGene CRISPR knockouts for PSMA2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PSMA2
- genomics-online: gRNA clones - Search results for 121 available PSMA2 gene related products
- Overview of 121 available PSMA2 gene related products
- Applied Biological Materials CRISPR for PSMA2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSMA2
- GenScript: Design CRISPR guide RNA sequences for PSMA2
miRNA for PSMA2 Gene
- miRTarBase miRNAs that target PSMA2
-
- hsa-mir-132-3p (MIRT021801)
- hsa-mir-29c-3p (MIRT044238)
- hsa-mir-186-5p (MIRT045072)
- hsa-mir-191-5p (MIRT045788)
- hsa-mir-100-5p (MIRT048439)
- hsa-mir-99a-5p (MIRT048696)
- hsa-let-7a-5p (MIRT052368)
- hsa-mir-548aw (MIRT510911)
- hsa-mir-1468-3p (MIRT510912)
- hsa-mir-548x-5p (MIRT510913)
- hsa-mir-548g-5p (MIRT510914)
- hsa-mir-548f-5p (MIRT510915)
- hsa-mir-3668 (MIRT510916)
- hsa-mir-548aj-5p (MIRT510917)
- hsa-mir-5680 (MIRT510918)
- hsa-mir-497-3p (MIRT510919)
- hsa-mir-651-5p (MIRT521586)
- hsa-mir-302c-5p (MIRT521587)
- hsa-mir-616-3p (MIRT521588)
- hsa-mir-153-5p (MIRT521589)
- hsa-mir-1250-3p (MIRT521590)
- hsa-mir-3159 (MIRT521591)
- hsa-mir-595 (MIRT521592)
- hsa-mir-548x-3p (MIRT521593)
- hsa-mir-548j-3p (MIRT521594)
- hsa-mir-548aq-3p (MIRT521595)
- hsa-mir-548am-3p (MIRT521596)
- hsa-mir-548aj-3p (MIRT521597)
- hsa-mir-548ah-3p (MIRT521598)
- hsa-mir-548ae-3p (MIRT521599)
- hsa-mir-548z (MIRT521600)
- hsa-mir-548h-3p (MIRT521601)
- hsa-mir-548d-3p (MIRT521602)
- hsa-mir-548bb-3p (MIRT521603)
- hsa-mir-548ac (MIRT521604)
- hsa-mir-212-3p (MIRT521605)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for PSMA2
- Browse OriGene Inhibitory RNA Products For PSMA2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMA2
- genomics-online: shRNA clones - Search results for 121 available PSMA2 gene related products
- Overview of 121 available PSMA2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for PSMA2
- VectorBuilder custom plasmid, inducible vectors for PSMA2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PSMA2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PSMA2
- Applied Biological Materials Clones for PSMA2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMA2 Gene
Localization for PSMA2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PSMA2 Gene
- Cytoplasm. Nucleus. Note=Colocalizes with TRIM5 in cytoplasmic bodies. {ECO:0000250 UniProtKB:P49722}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 5 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000502 | proteasome complex | IEA,IDA | 17323924 |
| GO:0000932 | P-body | ISS | -- |
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005634 | nucleus | IBA,IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PSMA2 Gene
Pathways & Interactions for PSMA2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | CDK-mediated phosphorylation and removal of Cdc6 |
.93
.93
|
.80
.78
.78
.70
.47
.31
|
| 2 | RET signaling |
.92
|
.92
|
| 3 | Chks in Checkpoint Regulation | ||
| 4 | HIV Life Cycle |
.64
|
.45
|
| 5 | Class I MHC mediated antigen processing and presentation | ||
Pathways by source for PSMA2 Gene
1 Sino Biological pathway for PSMA2 Gene
1 BioSystems pathway for PSMA2 Gene
1 KEGG pathway for PSMA2 Gene
4 GeneGo (Thomson Reuters) pathways for PSMA2 Gene
17 Qiagen pathways for PSMA2 Gene
Interacting Proteins for PSMA2 Gene
Selected Interacting proteins:
P25787-PSA2_HUMAN
ENSP00000223321
for PSMA2 Gene via
MINT
STRING
UniProtKB
IID
GPS-Prot Interaction Network for PSMA2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
| GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
| GO:0006508 | proteolysis | IEA | -- |
No data available for SIGNOR curated interactions for PSMA2 Gene
Drugs & Compounds for PSMA2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Bortezomib | Approved, Investigational | Pharma | inhibitor, other | Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors | 826 | |
| carfilzomib | Approved, Investigational | Pharma | other, Inhibitor | Other, 20S Proteasome Inhibitor | 0 | |
| (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE | Experimental | Pharma | Target | 0 |
Transcripts for PSMA2 Gene
mRNA/cDNA for PSMA2 Gene
- (1) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (644) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000223321 1487 bps (uc003thy.5)
- ENST00000436986 1453 bps (uc064dbj.1)
- ENST00000457444 801 bps (uc064dbk.1)
- ENST00000445517 683 bps (uc064dbl.1)
- ENST00000411875 4251 bps (uc064dbm.1)
Unigene Clusters for PSMA2 Gene
- Proteasome (prosome, macropain) subunit, alpha type, 2:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for PSMA2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PSMA2
- genomics-online: gRNA clones - Search results for 121 available PSMA2 gene related products
- Overview of 121 available PSMA2 gene related products
- Applied Biological Materials CRISPR for PSMA2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSMA2
- GenScript: Design CRISPR guide RNA sequences for PSMA2
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for PSMA2
- Browse OriGene Inhibitory RNA Products For PSMA2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMA2
- genomics-online: shRNA clones - Search results for 121 available PSMA2 gene related products
- Overview of 121 available PSMA2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for PSMA2
- VectorBuilder custom plasmid, inducible vectors for PSMA2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PSMA2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PSMA2
- Applied Biological Materials Clones for PSMA2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||
| SP3: | - |
Expression for PSMA2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Adipose (Muscoskeletal System)
This gene is overexpressed in Liver, secretome (11.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMA2 Gene
NURSA nuclear receptor signaling pathways regulating expression of PSMA2 Gene:
PSMA2SOURCE GeneReport for Unigene cluster for PSMA2 Gene:
Hs.333786Evidence on tissue expression from TISSUES for PSMA2 Gene
- Nervous system(4.8)
- Lung(4.7)
- Liver(4.6)
- Pancreas(2.9)
Primer Products
-
OriGene qPCR primer pairs and template standards for PSMA2
-
OriGene qPCR primer pairs for PSMA2
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMA2 Gene
Orthologs for PSMA2 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PSMA2 33 |
|
||
| dog (Canis familiaris) |
Mammalia | PSMA2 33 |
|
||
| -- 34 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | PSMA2 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Psma2 16 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Psma2 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | PSMA2 34 33 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | psma2 33 |
|
||
| Str.1067 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.2546 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | si:rp71-45k5.4 34 |
|
ManyToMany | |
| psma2 34 33 |
|
ManyToMany | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10816 33 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001995 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Pros25 34 35 33 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | pas-2 34 33 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PRE8 36 34 33 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0D10373g 33 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ADL354W 33 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT1G79210 33 |
|
||
| soybean (Glycine max) |
eudicotyledons | Gma.2259 33 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.1634 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os02g0634900 33 |
|
||
| Os.10566 33 |
|
||||
| corn (Zea mays) |
Liliopsida | Zm.16922 33 |
|
||
| wheat (Triticum aestivum) |
Liliopsida | Ta.14373 33 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | pre8 33 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU06764 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | Cin.15545 33 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.15545 33 |
|
- Species where no ortholog for PSMA2 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Evolution for PSMA2 Gene
- ENSEMBL:
- Gene Tree for PSMA2 (if available)
- TreeFam:
- Gene Tree for PSMA2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PSMA2: view image
Paralogs for PSMA2 Gene
Paralogs for PSMA2 Gene
(8) SIMAP similar genes for PSMA2 Gene using alignment to 6 proteins:
- PSA2_HUMAN
- C9JCK5_HUMAN
- F8WEG3_HUMAN
- H3BT36_HUMAN
- H7C3A7_HUMAN
- H7C402_HUMAN
Pseudogenes.org Pseudogenes for PSMA2 Gene
Variants for PSMA2 Gene
| SNP ID | Clin | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_036278 | A colorectal cancer sample | p.Leu110Val | |||
| rs1000067904 | -- | 42,926,125(-) | A/C | intron_variant | |
| rs1000138292 | -- | 42,932,316(-) | C/T | upstream_transcript_variant | |
| rs1000299247 | -- | 42,932,186(-) | G/A/T | 5_prime_UTR_variant | |
| rs1000664082 | -- | 42,919,591(-) | A/C | intron_variant |
Residual Variation Intolerance Score:
28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.08;
1.92% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PSMA2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PSMA2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMA2 Gene
Disorders for PSMA2 Gene
Additional Disease Information for PSMA2
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for PSMA2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMA2 Gene
Publications for PSMA2 Gene
- Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes). (PMID: 2025653) Tamura T … Ichihara A (Biochimica et biophysica acta 1991) 2 3 4 58
- Crystal structure of the human 20S proteasome in complex with carfilzomib. (PMID: 25599644) Harshbarger W … Sacchettini J (Structure (London, England : 1993) 2015) 3 4 58
- Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X … Huang L (Biochemistry 2007) 3 4 58
- Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. (PMID: 16548883) Leong WF … Chow VT (Cellular microbiology 2006) 3 4 58
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J … Comb MJ (Nature biotechnology 2005) 3 4 58
Products for PSMA2 Gene
- R&D Systems Antibodies for PSMA2 (PSMA2)
- Browse R&D Systems for Human Recombinant Proteins
- R&D Systems ELISAs and other biochemical assays for PSMA2 (PSMA2)
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Browse Immunoprecipitation Assays
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- Browse Proteome Profiler Antibody Arrays
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- Custom Antibody ServicesOriGene Antibodies for PSMA2
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for PSMA2
- Search Origene for MassSpec and Protein Over-expression Lysates for PSMA2
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- Origene sirna, shrna, and RNAi products in human, mouse, rat for PSMA2
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- OriGene qPCR primer pairs and template standards for PSMA2
- OriGene qPCR primer pairs for PSMA2
- OriGene CRISPR knockouts for PSMA2
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PSMA2
- GenScript: Next-day shipping of latest version cDNA ORF clones for PSMA2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for PSMA2
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- GenScript Custom overexpressing Cell Line Services for PSMA2
- GenScript: Design CRISPR guide RNA sequences for PSMA2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
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- Sino Biological Human cDNA Clone for PSMA2
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Abcam antibodies for PSMA2
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- Browse Primary Antibodies
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- ProSpec Recombinant Proteins for PSMA2
- Cyagen custom Knockout/knockin (KOKI) mouse models for PSMA2
- VectorBuilder custom plasmid, inducible vectors for PSMA2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PSMA2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 43 available PSMA2 Antibodies ranked by validation data
- Compare Top PSMA2 Antibodies
- antibodies-online: Search results for 1 available PSMA2 Elisa Kits ranked by validation data
- Compare Top PSMA2 Elisa Kits
- Recommended
- antibodies-online: Search results for 11 available PSMA2 Proteins ranked by validation data
- Compare Top PSMA2 Proteins
- GeneTex PSMA2 Antibody for PSMA2
- Search GeneTex for Proteins for PSMA2
- Santa Cruz Biotechnology (SCBT) Antibodies for PSMA2
- Search Santa Cruz Biotechnology (SCBT) for PSMA2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PSMA2
- genomics-online: cdna clones - Search results for 121 available PSMA2 gene related products
- Overview of 121 available PSMA2 gene related products
- orf clones - Search results for 121 available PSMA2 gene related products
- Overview of 121 available PSMA2 gene related products
- genomics-online: gRNA clones - Search results for 121 available PSMA2 gene related products
- Overview of 121 available PSMA2 gene related products
- genomics-online: primer clones - Search results for 121 available PSMA2 gene related products
- Overview of 121 available PSMA2 gene related products
- genomics-online: shRNA clones - Search results for 121 available PSMA2 gene related products
- Overview of 121 available PSMA2 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PSMA2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PSMA2
- GeneCopoeia miRNA 3'UTR Target clone products for PSMA2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMA2
Sources for PSMA2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40)