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Aliases for PSMA2 Gene

Aliases for PSMA2 Gene

  • Proteasome Subunit Alpha 2 2 3 5
  • Proteasome (Prosome, Macropain) Subunit, Alpha Type, 2 2 3
  • Multicatalytic Endopeptidase Complex Subunit C3 3 4
  • Proteasome Component C3 3 4
  • Macropain Subunit C3 3 4
  • HC3 3 4
  • Proteasome Subunit Alpha Type-2 3
  • Proteasome Subunit HC3 3
  • EC 3.4.25.1 4
  • PMSA2 3
  • PSC2 3
  • PSC3 4
  • MU 3

External Ids for PSMA2 Gene

Previous GeneCards Identifiers for PSMA2 Gene

  • GC07M042603
  • GC07M042663
  • GC07M042697
  • GC07M042729
  • GC07M042922
  • GC07M042841
  • GC07M042956

Summaries for PSMA2 Gene

Entrez Gene Summary for PSMA2 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. [provided by RefSeq, Jul 2008]

GeneCards Summary for PSMA2 Gene

PSMA2 (Proteasome Subunit Alpha 2) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and RET signaling. Gene Ontology (GO) annotations related to this gene include endopeptidase activity and threonine-type endopeptidase activity. An important paralog of this gene is ENSG00000256646.

UniProtKB/Swiss-Prot for PSMA2 Gene

  • Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).

Gene Wiki entry for PSMA2 Gene

Additional gene information for PSMA2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMA2 Gene

Genomics for PSMA2 Gene

GeneHancer (GH) Regulatory Elements for PSMA2 Gene

Promoters and enhancers for PSMA2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J042930 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.1 88 3.7 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 ZNF213 ZNF207 MRPL32 PSMA2 ENSG00000256646 C7orf25 LOC105375252
GH07J042945 Enhancer 1 Ensembl ENCODE 0.4 -13.9 -13884 1.1 HDAC1 HDGF PKNOX1 ATF1 TAF9B NFRKB CHAMP1 TCF12 POLR2B EGR1 C7orf25 HECW1 ENSG00000228680 MRPL32 PSMA2 GC07P043096
GH07J042940 Enhancer 0.9 Ensembl ENCODE 0.4 -9.2 -9159 0.9 CTCF MXI1 MAX SIN3A ZNF2 RAD21 CC2D1A GATA3 ARID2 SCRT2 C7orf25 MRPL32 PSMA2 GC07P043096
GH07J042972 Enhancer 0.9 Ensembl ENCODE 0.3 -41.2 -41158 1.8 USF1 CHAMP1 ZNF335 ZNF664 NFYB ZNF143 CBFA2T2 FOSL2 PRDM10 THAP11 MRPL32 C7orf25 PSMA2 GC07P043096 LOC105375253
GH07J042964 Enhancer 0.6 ENCODE 0.3 -32.8 -32750 0.7 SOX6 TEAD4 CEBPB EBF1 ZEB2 NR2F2 NCOR1 HDAC2 CBFA2T2 PSMA2 GC07P043096 LOC105375253
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PSMA2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PSMA2 gene promoter:

Genomic Locations for PSMA2 Gene

Genomic Locations for PSMA2 Gene
chr7:42,916,857-42,932,223
(GRCh38/hg38)
Size:
15,367 bases
Orientation:
Minus strand
chr7:42,956,460-42,971,822
(GRCh37/hg19)

Genomic View for PSMA2 Gene

Genes around PSMA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMA2 Gene

Proteins for PSMA2 Gene

  • Protein details for PSMA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25787-PSA2_HUMAN
    Recommended name:
    Proteasome subunit alpha type-2
    Protein Accession:
    P25787
    Secondary Accessions:
    • Q6ICS6
    • Q9BU45

    Protein attributes for PSMA2 Gene

    Size:
    234 amino acids
    Molecular mass:
    25899 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.

    Three dimensional structures from OCA and Proteopedia for PSMA2 Gene

neXtProt entry for PSMA2 Gene

Post-translational modifications for PSMA2 Gene

  • Phosphorylated on tyrosine residues; which may be important for nuclear import.
  • Ubiquitination at posLast=171171, posLast=165165, Lys92, Lys70, posLast=5353, and posLast=3939
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMA2 Gene

No data available for DME Specific Peptides for PSMA2 Gene

Domains & Families for PSMA2 Gene

Gene Families for PSMA2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PSMA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P25787

UniProtKB/Swiss-Prot:

PSA2_HUMAN :
  • Belongs to the peptidase T1A family.
Family:
  • Belongs to the peptidase T1A family.
genes like me logo Genes that share domains with PSMA2: view

Function for PSMA2 Gene

Molecular function for PSMA2 Gene

UniProtKB/Swiss-Prot Function:
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of peptide bonds with very broad specificity.
UniProtKB/Swiss-Prot Induction:
Down-regulated by antioxidants BO-653 and probucol. Down-regulated in response to enterovirus 71 (EV71) infection (at protein level).
GENATLAS Biochemistry:
multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,alpha type 2,subunit HC3,25.9 kDa,would be localized in 7p13-p12 (Trachtulec)

Enzyme Numbers (IUBMB) for PSMA2 Gene

Gene Ontology (GO) - Molecular Function for PSMA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IEA,IBA --
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 12376572
GO:0008233 peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PSMA2: view
genes like me logo Genes that share phenotypes with PSMA2: view

Animal Model Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMA2 Gene

Localization for PSMA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMA2 Gene

Cytoplasm. Nucleus. Note=Colocalizes with TRIM5 in cytoplasmic bodies. {ECO:0000250 UniProtKB:P49722}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMA2 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
cytoskeleton 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PSMA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IEA,IDA 17323924
GO:0000932 P-body ISS --
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IBA,IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with PSMA2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PSMA2 Gene

Pathways & Interactions for PSMA2 Gene

SuperPathways for PSMA2 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 Chks in Checkpoint Regulation
4 HIV Life Cycle
.45
5 Class I MHC mediated antigen processing and presentation
genes like me logo Genes that share pathways with PSMA2: view

Gene Ontology (GO) - Biological Process for PSMA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PSMA2: view

No data available for SIGNOR curated interactions for PSMA2 Gene

Drugs & Compounds for PSMA2 Gene

(3) Drugs for PSMA2 Gene - From: DrugBank and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 826
carfilzomib Approved, Investigational Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Experimental Pharma Target 0
genes like me logo Genes that share compounds with PSMA2: view

Transcripts for PSMA2 Gene

mRNA/cDNA for PSMA2 Gene

Unigene Clusters for PSMA2 Gene

Proteasome (prosome, macropain) subunit, alpha type, 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMA2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1:
SP2: -
SP3: -

Relevant External Links for PSMA2 Gene

GeneLoc Exon Structure for
PSMA2
ECgene alternative splicing isoforms for
PSMA2

Expression for PSMA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSMA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PSMA2 Gene

This gene is overexpressed in Liver, secretome (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMA2 Gene



Protein tissue co-expression partners for PSMA2 Gene

NURSA nuclear receptor signaling pathways regulating expression of PSMA2 Gene:

PSMA2

SOURCE GeneReport for Unigene cluster for PSMA2 Gene:

Hs.333786

Evidence on tissue expression from TISSUES for PSMA2 Gene

  • Nervous system(4.8)
  • Lung(4.7)
  • Liver(4.6)
  • Pancreas(2.9)
genes like me logo Genes that share expression patterns with PSMA2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMA2 Gene

Orthologs for PSMA2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMA2 33
  • 100 (n)
dog
(Canis familiaris)
Mammalia PSMA2 33
  • 94.44 (n)
-- 34
  • 89 (a)
OneToMany
cow
(Bos Taurus)
Mammalia PSMA2 33
  • 94.16 (n)
mouse
(Mus musculus)
Mammalia Psma2 16 33
  • 91.45 (n)
rat
(Rattus norvegicus)
Mammalia Psma2 33
  • 90.88 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 80 (a)
OneToMany
chicken
(Gallus gallus)
Aves PSMA2 34 33
  • 84.62 (n)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 99 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia psma2 33
  • 83.48 (n)
Str.1067 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.2546 33
zebrafish
(Danio rerio)
Actinopterygii si:rp71-45k5.4 34
  • 95 (a)
ManyToMany
psma2 34 33
  • 78.06 (n)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10816 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001995 33
  • 69.24 (n)
fruit fly
(Drosophila melanogaster)
Insecta Pros25 34 35 33
  • 68.24 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pas-2 34 33
  • 62.96 (n)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRE8 36 34 33
  • 58.33 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D10373g 33
  • 57.33 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL354W 33
  • 54.45 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G79210 33
  • 66.09 (n)
soybean
(Glycine max)
eudicotyledons Gma.2259 33
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1634 33
rice
(Oryza sativa)
Liliopsida Os02g0634900 33
  • 65.09 (n)
Os.10566 33
corn
(Zea mays)
Liliopsida Zm.16922 33
wheat
(Triticum aestivum)
Liliopsida Ta.14373 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pre8 33
  • 60.59 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06764 33
  • 57.88 (n)
sea squirt
(Ciona savignyi)
Ascidiacea Cin.15545 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15545 33
Species where no ortholog for PSMA2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMA2 Gene

ENSEMBL:
Gene Tree for PSMA2 (if available)
TreeFam:
Gene Tree for PSMA2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PSMA2: view image

Paralogs for PSMA2 Gene

Paralogs for PSMA2 Gene

(8) SIMAP similar genes for PSMA2 Gene using alignment to 6 proteins:

  • PSA2_HUMAN
  • C9JCK5_HUMAN
  • F8WEG3_HUMAN
  • H3BT36_HUMAN
  • H7C3A7_HUMAN
  • H7C402_HUMAN

Pseudogenes.org Pseudogenes for PSMA2 Gene

genes like me logo Genes that share paralogs with PSMA2: view

Variants for PSMA2 Gene

Sequence variations from dbSNP and Humsavar for PSMA2 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
VAR_036278 A colorectal cancer sample p.Leu110Val
rs1000067904 -- 42,926,125(-) A/C intron_variant
rs1000138292 -- 42,932,316(-) C/T upstream_transcript_variant
rs1000299247 -- 42,932,186(-) G/A/T 5_prime_UTR_variant
rs1000664082 -- 42,919,591(-) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PSMA2 Gene

Variant ID Type Subtype PubMed ID
nsv606715 CNV gain 21841781
nsv830979 CNV gain 17160897

Variation tolerance for PSMA2 Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PSMA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMA2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMA2 Gene

Disorders for PSMA2 Gene

Additional Disease Information for PSMA2

No disorders were found for PSMA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMA2 Gene

Publications for PSMA2 Gene

  1. Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes). (PMID: 2025653) Tamura T … Ichihara A (Biochimica et biophysica acta 1991) 2 3 4 58
  2. Crystal structure of the human 20S proteasome in complex with carfilzomib. (PMID: 25599644) Harshbarger W … Sacchettini J (Structure (London, England : 1993) 2015) 3 4 58
  3. Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X … Huang L (Biochemistry 2007) 3 4 58
  4. Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. (PMID: 16548883) Leong WF … Chow VT (Cellular microbiology 2006) 3 4 58
  5. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J … Comb MJ (Nature biotechnology 2005) 3 4 58

Products for PSMA2 Gene

Sources for PSMA2 Gene