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The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiq... See more...
Aliases for PSMA2 Gene
Aliases for PSMA2 Gene
External Ids for PSMA2 Gene
- HGNC: 9531
- NCBI Entrez Gene: 5683
- Ensembl: ENSG00000106588
- OMIM®: 176842
- UniProtKB/Swiss-Prot: P25787
Previous GeneCards Identifiers for PSMA2 Gene
- GC07M042603
- GC07M042663
- GC07M042697
- GC07M042729
- GC07M042922
- GC07M042841
- GC07M042956
Summaries for PSMA2 Gene
-
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. [provided by RefSeq, Jul 2008]
GeneCards Summary for PSMA2 Gene
PSMA2 (Proteasome 20S Subunit Alpha 2) is a Protein Coding gene. Diseases associated with PSMA2 include Cystic Fibrosis. Among its related pathways are Downstream signaling events of B Cell Receptor (BCR) and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include endopeptidase activity and threonine-type endopeptidase activity. An important paralog of this gene is ENSG00000256646.
UniProtKB/Swiss-Prot Summary for PSMA2 Gene
-
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
Additional gene information for PSMA2 Gene
- HGNC (9531)
- NCBI Entrez Gene (5683)
- Ensembl (ENSG00000106588)
- OMIM® (176842)
- UniProtKB/Swiss-Prot (P25787)
- Open Targets Platform(ENSG00000106588)
- Monarch Initiative
- Search for PSMA2 at DataMed
- Search for PSMA2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSMA2 Gene
Genomics for PSMA2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PSMA2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH07J042929 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE CraniofacialAtlas | 250.7 | +0.3 | 284 | 5 | TBP SP1 MXD4 SIX5 NR2C1 MNT IKZF1 SMAD5 ETS1 IRF2 | MRPL32 ENSG00000256646 PSMA2 NONHSAG047444.2 C7orf25 HECW1 ENSG00000261019 HSALNG0057543 | |
| GH07J042913 | Enhancer | 0.7 | FANTOM5 ENCODE | 0.4 | +17.8 | 17760 | 1.4 | POLR2A ZMYM3 ZBTB17 RUNX3 CEBPB ZNF121 | C7orf25 MRPL32 LOC105375252 ENSG00000256646 PSMA2 | |
| GH07J042915 | Enhancer | 0.2 | ENCODE | 0.4 | +16.7 | 16688 | 0.2 | C7orf25 LOC105375252 ENSG00000256646 PSMA2 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PSMA2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PSMA2
- Top Transcription factor binding sites by QIAGEN in the PSMA2 gene promoter:
-
- aMEF-2
- AML1a
- AP-2rep
- AREB6
- CUTL1
- FAC1
- FOXL1
- MEF-2A
- Pax-3
- PPAR-gamma2
Genomic Locations for PSMA2 Gene
Latest Assembly
- chr7:42,916,828-42,932,185
- (GRCh38/hg38)
- Size:
- 15,358 bases
- Orientation:
- Minus strand
Previous Assembly
- chr7:42,956,460-42,971,773
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 15,314 bases
- Orientation:
- Minus strand
- chr7:42,956,460-42,971,822
- (GRCh37/hg19 by Ensembl)
- Size:
- 15,363 bases
- Orientation:
- Minus strand
Genomic View for PSMA2 Gene
Genes around PSMA2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7p14.1 by HGNC
- 7p14.1 by Entrez Gene
- 7p14.1 by Ensembl
PSMA2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PSMA2 Gene
Proteins for PSMA2 Gene
-
Protein details for PSMA2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P25787-PSA2_HUMAN
- Recommended name:
- Proteasome subunit alpha type-2
- Protein Accession:
- P25787
- Q6ICS6
- Q9BU45
Protein attributes for PSMA2 Gene
- Size:
- 234 amino acids
- Molecular mass:
- 25899 Da
- Quaternary structure:
-
- The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.
Protein Expression for PSMA2 Gene
Selected DME Specific Peptides for PSMA2 Gene
- P25787:
-
- GGVRPFG
- TTFSPSG
- DPSGAYF
- RPFGVSLL
- NGVVLATEKKQKSILYDE
- LELEDAIH
- HTAILTLKE
- VYSGMGPD
- RARKLAQQY
- EPITKHIG
- GKLVQIE
- TQSGGVRP
- LVYQEPIPT
- TFLEKRY
- FSLTTFSP
Post-translational modifications for PSMA2 Gene
- Phosphorylated on tyrosine residues; which may be important for nuclear import.
-
Ubiquitination at Lys39, Lys53, Lys70, Lys92, Lys165, and Lys171
- NX_P25787 (NX_P25787-1)
- Modification sites at PhosphoSitePlus
Other Protein References for PSMA2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- G Biosciences Immunotag™ PSMA2 Antibody
- Novus Biologicals Antibodies for PSMA2
-
Abcam antibodies for PSMA2
- Invitrogen Antibodies for PSMA2 (AFLGC-Psma2)
-
Santa Cruz Biotechnology (SCBT) Antibodies for PSMA2
- Sino Biological Antibodies for PSMA2
Protein products for research
-
OriGene Purified Proteins for PSMA2
- Search Origene for MassSpec and Protein Over-expression Lysates for PSMA2
- Origene Custom Protein Services for PSMA2
- ProSpec Recombinant Proteins for PSMA2
-
Abcam proteins for PSMA2
Domains & Families for PSMA2 Gene
Gene Families for PSMA2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for PSMA2 Gene
- InterPro:
- Blocks:
-
- Proteasome subunit, A-type
- ProtoNet:
Suggested Antigen Peptide Sequences for PSMA2 Gene
- GenScript: Design optimal peptide antigens:
-
- Proteasome component C3 (PSA2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P25787- Family:
-
- Belongs to the peptidase T1A family.
Function for PSMA2 Gene
Molecular function for PSMA2 Gene
- UniProtKB/Swiss-Prot Function:
- Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
- UniProtKB/Swiss-Prot Induction:
- Down-regulated by antioxidants BO-653 and probucol. Down-regulated in response to enterovirus 71 (EV71) infection (at protein level).
- GENATLAS Biochemistry:
- multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,alpha type 2,subunit HC3,25.9 kDa,would be localized in 7p13-p12 (Trachtulec)
Enzyme Numbers (IUBMB) for PSMA2 Gene
Phenotypes From GWAS Catalog for PSMA2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004175 | endopeptidase activity | IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 12376572 |
Phenotypes for PSMA2 Gene
- GenomeRNAi human phenotypes for PSMA2:
-
- Increased gamma-H2AX phosphorylation
- Decreased viability
- no effect
- shRNA abundance <= 50%
- Reduced mammosphere formation
- Dynamic nuclei (hole, folded or small irregular)
- FOXO1 nuclear localization
- shRNA abundance <= 25%
- Increased shRNA abundance (Z-score > 2)
- Decreased homologous recombination repair frequency
- Decreased shRNA abundance
- Synthetic lethal with vaccinia virus (VACV) infection
- Decreased cell number
- Decreased viability of wild-type and TP53 knockout cells
- Decreased shRNA abundance (Z-score < -2)
- Decreased HIV-1 infection
- HIV Rev nuclear localization
- Decreased viability in ovarian lineage; decreased viability in pancreas lineage
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PSMA2 - Starting at $85 >
- * PSMA2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PSMA2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PSMA2
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSMA2
miRNA for PSMA2 Gene
- miRTarBase miRNAs that target PSMA2
-
- hsa-miR-132-3p (MIRT021801)
- hsa-miR-29c-3p (MIRT044238)
- hsa-miR-186-5p (MIRT045072)
- hsa-miR-191-5p (MIRT045788)
- hsa-miR-100-5p (MIRT048439)
- hsa-miR-99a-5p (MIRT048696)
- hsa-let-7a-5p (MIRT052368)
- hsa-miR-548aw (MIRT510911)
- hsa-miR-1468-3p (MIRT510912)
- hsa-miR-548x-5p (MIRT510913)
- hsa-miR-548g-5p (MIRT510914)
- hsa-miR-548f-5p (MIRT510915)
- hsa-miR-3668 (MIRT510916)
- hsa-miR-548aj-5p (MIRT510917)
- hsa-miR-5680 (MIRT510918)
- hsa-miR-497-3p (MIRT510919)
- hsa-miR-651-5p (MIRT521586)
- hsa-miR-302c-5p (MIRT521587)
- hsa-miR-616-3p (MIRT521588)
- hsa-miR-153-5p (MIRT521589)
- hsa-miR-1250-3p (MIRT521590)
- hsa-miR-3159 (MIRT521591)
- hsa-miR-595 (MIRT521592)
- hsa-miR-548x-3p (MIRT521593)
- hsa-miR-548j-3p (MIRT521594)
- hsa-miR-548aq-3p (MIRT521595)
- hsa-miR-548am-3p (MIRT521596)
- hsa-miR-548aj-3p (MIRT521597)
- hsa-miR-548ah-3p (MIRT521598)
- hsa-miR-548ae-3p (MIRT521599)
- hsa-miR-548z (MIRT521600)
- hsa-miR-548h-3p (MIRT521601)
- hsa-miR-548d-3p (MIRT521602)
- hsa-miR-548bb-3p (MIRT521603)
- hsa-miR-548ac (MIRT521604)
- hsa-miR-212-3p (MIRT521605)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PSMA2
- Browse OriGene Inhibitory RNA Products For PSMA2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMA2
Clone products for research
- Applied Biological Materials (abm): Clones for PSMA2 - Starting at $45 >
- * PSMA2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for PSMA2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PSMA2
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMA2 Gene
Localization for PSMA2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PSMA2 Gene
- Cytoplasm. Nucleus. Note=Colocalizes with TRIM5 in cytoplasmic bodies. {ECO:0000250 UniProtKB:P49722}.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| extracellular | 4 |
| nucleus | 4 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| plasma membrane | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000502 | proteasome complex | IEA,IDA | 17323924 |
| GO:0000932 | P-body | IEA,ISS | -- |
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005634 | nucleus | IEA,IBA | 21873635 |
| GO:0005654 | nucleoplasm | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PSMA2 Gene
Pathways & Interactions for PSMA2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | CDK-mediated phosphorylation and removal of Cdc6 |
.93
.93
|
.80
.80
.78
.70
.47
.31
|
| 2 | RET signaling |
.92
|
.92
|
| 3 | Chks in Checkpoint Regulation |
Chks in Checkpoint Regulation
.59
G2-M Phase Transition
.59
Estrogen-mediated S-Phase Entry
.55
|
SREBP Proteolysis
.43
DNA Repair Mechanisms
.32
Parkinson's Disease Pathway
.31
|
| 4 | HIV Life Cycle |
.64
|
.45
|
| 5 | Pathways of neurodegeneration - multiple diseases | ||
Pathways by source for PSMA2 Gene
1 Sino Biological pathway for PSMA2 Gene
1 BioSystems pathway for PSMA2 Gene
8 KEGG pathways for PSMA2 Gene
4 GeneGo (Thomson Reuters) pathways for PSMA2 Gene
- Immune response Antigen presentation by MHC class I
- Regulation of degradation of deltaF508 CFTR in CF
- Regulation of degradation of wt-CFTR
- Transcription Ligand-Dependent Transcription of Retinoid-Target genes
17 Qiagen pathways for PSMA2 Gene
- CDK5 Pathway
- Chks in Checkpoint Regulation
- DNA Repair Mechanisms
- Estrogen-mediated S-Phase Entry
- G2-M Phase Transition
Interacting Proteins for PSMA2 Gene
Selected Interacting proteins:
P25787-PSA2_HUMAN
ENSP00000223321
for PSMA2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for PSMA2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
| GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
| GO:0006511 | ubiquitin-dependent protein catabolic process | IEA | -- |
No data available for SIGNOR curated interactions for PSMA2 Gene
Drugs & Compounds for PSMA2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Bortezomib | Approved, Investigational | Pharma | inhibitor, other | Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors | 926 | |
| carfilzomib | Approved, Investigational | Pharma | other, Inhibitor | Other, 20S Proteasome Inhibitor | 0 | |
| (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE | Experimental | Pharma | Target | 0 |
Transcripts for PSMA2 Gene
mRNA/cDNA for PSMA2 Gene
- 1 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000223321 1434 nts (view in UCSC)
- ENST00000411875 4251 nts (view in UCSC)
- ENST00000436986 1453 nts (view in UCSC)
- ENST00000445517 683 nts (view in UCSC)
- ENST00000457444 1289 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PSMA2 - Starting at $85 >
- * PSMA2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PSMA2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PSMA2
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSMA2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PSMA2
- Browse OriGene Inhibitory RNA Products For PSMA2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMA2
Clone products for research
- Applied Biological Materials (abm): Clones for PSMA2 - Starting at $45 >
- * PSMA2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for PSMA2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PSMA2
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||
| SP3: | - |
Relevant External Links for PSMA2 Gene
- GeneLoc Exon Structure for
- PSMA2
Expression for PSMA2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Adipose (Muscoskeletal System)
This gene is overexpressed in Liver, secretome (11.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSMA2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PSMA2
SOURCE GeneReport for Unigene cluster for PSMA2 Gene:
Hs.333786Evidence on tissue expression from TISSUES for PSMA2 Gene
- Nervous system(4.9)
- Lung(4.7)
- Liver(4.7)
- Pancreas(3.2)
- Skin(2.6)
- Kidney(2.4)
- Intestine(2.4)
- Muscle(2.3)
- Heart(2.2)
- Bone marrow(2.2)
- Spleen(2)
Primer products for research
-
OriGene qPCR primer pairs for PSMA2
-
OriGene qPCR primer pairs and template standards for PSMA2
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMA2 Gene
Orthologs for PSMA2 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PSMA2 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | PSMA2 30 |
|
||
| -- 31 |
|
OneToMany | |||
| Cow (Bos Taurus) |
Mammalia | PSMA2 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Psma2 30 17 |
|
||
| Rat (Rattus norvegicus) |
Mammalia | Psma2 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| Chicken (Gallus gallus) |
Aves | PSMA2 30 31 |
|
OneToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | psma2 30 |
|
||
| Str.1067 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.2546 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | si:rp71-45k5.4 31 |
|
ManyToMany | |
| psma2 30 31 |
|
ManyToMany | |||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10816 30 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001995 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Pros25 30 31 32 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | pas-2 30 31 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PRE8 30 31 33 |
|
OneToMany | |
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0D10373g 30 |
|
||
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ADL354W 30 |
|
||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT1G79210 30 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.1634 30 |
|
||
| Soybean (Glycine max) |
eudicotyledons | Gma.2259 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os02g0634900 30 |
|
||
| Os.10566 30 |
|
||||
| Wheat (Triticum aestivum) |
Liliopsida | Ta.14373 30 |
|
||
| Corn (Zea mays) |
Liliopsida | Zm.16922 30 |
|
||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | pre8 30 |
|
||
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU06764 30 |
|
||
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.15545 30 |
|
- Species where no ortholog for PSMA2 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Evolution for PSMA2 Gene
- ENSEMBL:
- Gene Tree for PSMA2 (if available)
- TreeFam:
- Gene Tree for PSMA2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PSMA2: view image
Paralogs for PSMA2 Gene
Paralogs for PSMA2 Gene
(8) SIMAP similar genes for PSMA2 Gene using alignment to 6 proteins:
- PSA2_HUMAN
- C9JCK5_HUMAN
- F8WEG3_HUMAN
- H3BT36_HUMAN
- H7C3A7_HUMAN
- H7C402_HUMAN
Pseudogenes.org Pseudogenes for PSMA2 Gene
Variants for PSMA2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PSMA2 Gene
| SNP ID | Clinical significance and condition | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs28503255 | Benign: not provided | 42,923,394(-) |
T/C NM_002787.5(PSMA2):c.387A>G (p.Pro129=) |
SYNONYMOUS | |
| VAR_036278 | A colorectal cancer sample |
p.Leu110Val |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.08;
1.92% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PSMA2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PSMA2
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMA2 Gene
Disorders for PSMA2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cystic fibrosis |
|
|
Search PSMA2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PSMA2
- Genetic Association Database
- (GAD)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PSMA2 Gene
Publications for PSMA2 Gene
- Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes). (PMID: 2025653) Tamura T … Ichihara A (Biochimica et biophysica acta 1991) 2 3 4
- An atomic structure of the human 26S proteasome. (PMID: 27428775) Huang X … Shi Y (Nature structural & molecular biology 2016) 3 4
- Crystal structure of the human 20S proteasome in complex with carfilzomib. (PMID: 25599644) Harshbarger W … Sacchettini J (Structure (London, England : 1993) 2015) 3 4
- Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X … Huang L (Biochemistry 2007) 3 4
- Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. (PMID: 16548883) Leong WF … Chow VT (Cellular microbiology 2006) 3 4
ExternalLinks
Products for PSMA2 Gene
- Custom Antibody ServicesOriGene Antibodies for PSMA2
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for PSMA2
- Search Origene for MassSpec and Protein Over-expression Lysates for PSMA2
- Origene Custom Protein Services for PSMA2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PSMA2
- Browse OriGene Inhibitory RNA Products For PSMA2
- OriGene qPCR primer pairs for PSMA2
- OriGene qPCR primer pairs and template standards for PSMA2
- OriGene CRISPR knockouts for PSMA2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PSMA2
- Sino Biological Human cDNA Clone for PSMA2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for PSMA2
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for PSMA2
- Novus Biologicals proteins and lysates for PSMA2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for PSMA2
- Abcam proteins for PSMA2
- Find your target
- Browse Primary Antibodies
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- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for PSMA2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for PSMA2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for PSMA2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for PSMA2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for PSMA2
- antibodies-online: Show 18 available PSMA2 Antibodies ranked by validation data
- Compare Top PSMA2 Antibodies
- antibodies-online: Show 2 available PSMA2 Elisa Kits ranked by validation data
- Compare Top PSMA2 Elisa Kits
- antibodies-online: Show 11 available PSMA2 Proteins ranked by validation data
- Compare Top PSMA2 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for PSMA2
- Search Santa Cruz Biotechnology (SCBT) for PSMA2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PSMA2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PSMA2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PSMA2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for PSMA2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSMA2
Sources for PSMA2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB