Aliases for PSMA1 Gene
Aliases for PSMA1 Gene
External Ids for PSMA1 Gene
- HGNC: 9530
- Entrez Gene: 5682
- Ensembl: ENSG00000129084
- OMIM: 602854
- UniProtKB: P25786
Previous GeneCards Identifiers for PSMA1 Gene
- GC11M015706
- GC11M015274
- GC11M014565
- GC11M014490
- GC11M014482
- GC11M014207
Summaries for PSMA1 Gene
-
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]
GeneCards Summary for PSMA1 Gene
PSMA1 (Proteasome Subunit Alpha 1) is a Protein Coding gene. Diseases associated with PSMA1 include Male Reproductive Organ Cancer and Farmer's Lung. Among its related pathways are RET signaling and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include RNA binding and threonine-type endopeptidase activity. An important paralog of this gene is ENSG00000256206.
UniProtKB/Swiss-Prot for PSMA1 Gene
-
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMA1 Gene
Genomics for PSMA1 Gene
GeneHancer (GH) Regulatory Elements for PSMA1 Gene
Promoters and enhancers for PSMA1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PSMA1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PSMA1 gene promoter:
Regulatory Element Products
Genomic Locations for PSMA1 Gene
Genomic Locations for PSMA1 Gene
- chr11:14,504,874-14,643,635
- (GRCh38/hg38)
- Size:
- 138,762 bases
- Orientation:
- Minus strand
- chr11:14,515,329-14,665,181
- (GRCh37/hg19)
Genomic View for PSMA1 Gene
Genes around PSMA1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p15.2 by Ensembl
- 11p15.2 by Entrez Gene
- 11p15.2 by HGNC
PSMA1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PSMA1 Gene
Proteins for PSMA1 Gene
-
Protein details for PSMA1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P25786-PSA1_HUMAN
- Recommended name:
- Proteasome subunit alpha type-1
- Protein Accession:
- P25786
- A8K400
- Q53YE8
- Q9BRV9
Protein attributes for PSMA1 Gene
- Size:
- 263 amino acids
- Molecular mass:
- 29556 Da
- Quaternary structure:
-
- The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. Interacts with NOTCH3.
Three dimensional structures from OCA and Proteopedia for PSMA1 Gene
Protein Expression for PSMA1 Gene
Selected DME Specific Peptides for PSMA1 Gene
- P25786:
-
- KNVSIGIVG
- THAVLVALKR
- GVGLLIAGYD
- EYAMEAV
- RPYGVGLL
- KQGSATVG
- ARTYLERH
- EFTIYDDDDV
- HGLRALRET
- GLTADAR
Post-translational modifications for PSMA1 Gene
Other Protein References for PSMA1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for PSMA1 (PSMA1)
- Novus Biologicals Antibodies for PSMA1
-
Abcam antibodies for PSMA1
-
Cloud-Clone Corp. Antibodies for PSMA1
- Invitrogen Antibodies for PSMA1
- GeneTex PSMA1 antibody for PSMA1
-
Santa Cruz Biotechnology (SCBT) Antibodies for PSMA1
Protein Products
-
OriGene Purified Proteins for PSMA1
- Search Origene for MassSpec and Protein Over-expression Lysates for PSMA1
- Origene Custom Protein Services for PSMA1
- ProSpec Recombinant Proteins for PSMA1
-
Cloud-Clone Corp. Proteins for PSMA1
- Search GeneTex for Proteins for PSMA1
-
Abcam proteins for PSMA1
Assay Products
-
Cloud-Clone Corp. Assay Kits for PSMA1
- antibodies-online: Search results for 6 available PSMA1 Elisa Kits ranked by validation data
- Compare Top PSMA1 Elisa Kits
-
Recommended
Domains & Families for PSMA1 Gene
Gene Families for PSMA1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for PSMA1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PSMA1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P25786- Family:
-
- Belongs to the peptidase T1A family.
Function for PSMA1 Gene
Molecular function for PSMA1 Gene
- GENATLAS Biochemistry:
- multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,alpha type 1,subunit Pros30,30kDa
- UniProtKB/Swiss-Prot CatalyticActivity:
- Cleavage of peptide bonds with very broad specificity.
- UniProtKB/Swiss-Prot Function:
- Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
- UniProtKB/Swiss-Prot Induction:
- Induced in breast cancer tissue (at protein level). Up-regulated in liver tumor tissues.
Enzyme Numbers (IUBMB) for PSMA1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | TAS | 7681138 |
| GO:0004175 | endopeptidase activity | IEA | -- |
| GO:0004298 | threonine-type endopeptidase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 12376572 |
| GO:0008233 | peptidase activity | IEA | -- |
Phenotypes for PSMA1 Gene
- GenomeRNAi human phenotypes for PSMA1:
-
- Increased vaccinia virus (VACV) infection
- Decreased hepcidin::fluc mRNA expression
- shRNA abundance <= 50%
- Synthetic lethal with Ras
- Decreased viability in esophageal squamous lineage
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Increased shRNA abundance (Z-score > 2)
- Increased G1 DNA content
- G0/1 arrest
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability
- Decreased Salmonella enterica Typhimurium ruffling
- Decreased Salmonella enterica Typhimurium invasion
- Decreased Salmonella enterica Typhimurium effector injection
- Decreased homologous recombination repair frequency
- Decreased shRNA abundance
- Decreased influenza A/WSN/33 replication
- Decreased cell number
- Decreased viability of wild-type and TP53 knockout cells
- Decreased Salmonella-containing vacuole maturation
- Decreased Salmonella enterica Typhimurium membrane closure
- Decreased HIV-1 infection
- Decreased influenza A H1N1 (A/WSN/33) virus numbers
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PSMA1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for PSMA1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PSMA1 gene
- Search ViGene Biosciences for PSMA1
CRISPR Products
-
OriGene CRISPR knockouts for PSMA1
- genomics-online: gRNA clones - Search results for 157 available PSMA1 gene related products
- Overview of 157 available PSMA1 gene related products
- Applied Biological Materials CRISPR for PSMA1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSMA1
- GenScript: Design CRISPR guide RNA sequences for PSMA1
miRNA for PSMA1 Gene
- miRTarBase miRNAs that target PSMA1
miRNA Products
- Search ViGene Biosciences for PSMA1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PSMA1
- Browse OriGene Inhibitory RNA Products For PSMA1
- genomics-online: shRNA clones - Search results for 157 available PSMA1 gene related products
- Overview of 157 available PSMA1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PSMA1 gene
Clone Products
-
OriGene ORF clones in human for PSMA1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PSMA1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PSMA1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PSMA1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for PSMA1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for PSMA1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PSMA1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PSMA1 gene
No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMA1 Gene
Localization for PSMA1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PSMA1 Gene
- Cytoplasm. Nucleus.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 5 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000502 | proteasome complex | IDA,TAS | 17323924 |
| GO:0005634 | nucleus | IDA,TAS | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005813 | centrosome | IDA | -- |
Pathways & Interactions for PSMA1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | CDK-mediated phosphorylation and removal of Cdc6 |
.93
.93
|
.80
.78
.78
.70
.47
.31
|
| 2 | RET signaling |
.92
|
.92
|
| 3 | Chks in Checkpoint Regulation | ||
| 4 | HIV Life Cycle |
.65
|
.45
|
| 5 | Class I MHC mediated antigen processing and presentation | ||
Pathways by source for PSMA1 Gene
1 Sino Biological pathway for PSMA1 Gene
1 BioSystems pathway for PSMA1 Gene
1 KEGG pathway for PSMA1 Gene
4 GeneGo (Thomson Reuters) pathways for PSMA1 Gene
17 Qiagen pathways for PSMA1 Gene
Interacting Proteins for PSMA1 Gene
Selected Interacting proteins:
ENSP00000414359
P25786-PSA1_HUMAN
for PSMA1 Gene via
STRING
MINT
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
No data available for SIGNOR curated interactions for PSMA1 Gene
Drugs & Compounds for PSMA1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Bortezomib | Approved, Investigational | Pharma | inhibitor, other | Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors | 826 | |
| carfilzomib | Approved, Investigational | Pharma | other, Inhibitor | Other, 20S Proteasome Inhibitor | 0 | |
| (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE | Experimental | Pharma | Target | 0 | ||
| AM 114 | Pharma | 20S proteasome inhibitor | 0 | |||
| Bortezomib (PS-341) | Pharma | Proteasome Inhibitor | 0 |
(14) ApexBio Compounds for PSMA1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| AM 114 | 20S proteasome inhibitor | 856849-35-9 |
| Bortezomib (PS-341) | Proteasome Inhibitor | 179324-69-7 |
| Carfilzomib (PR-171) | Proteasome inhibitor,epoxomicin analog | 868540-17-4 |
| Celastrol | Antioxidant, anti-inflammatory and immunosuppressive agent | 34157-83-0 |
| CEP-18770 | Proteasome inhibitor | 847499-27-8 |
| Dihydroeponemycin | Proteasome inhibitor,antitumor reagent,eponemycin ddrivative | 126463-64-7 |
| Epoxomicin | Proteasome inhibitor | 134381-21-8 |
| MG-132 | Proteasome inhibitor, Cell permeable, reversible | 133407-82-6 |
| MLN2238 | β5 site of the 20S proteasome inhibitor | 1072833-77-2 |
| MLN9708 | Proteasome inhibitor | 1201902-80-8 |
| ONX-0914 (PR-957) | Immunoproteasome inhibitor,potent and selective | 960374-59-8 |
| Oprozomib (ONX-0912) | Proteasome inhibitor | 935888-69-0 |
| PI-1840 | Chymotrypsin-like (CT-L) inhibitor | 1401223-22-0 |
| PSI | Proteasome inhibitor | 158442-41-2 |
Transcripts for PSMA1 Gene
mRNA/cDNA for PSMA1 Gene
- (3) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (584) Selected AceView cDNA sequences:
- (14) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PSMA1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for PSMA1
- genomics-online: gRNA clones - Search results for 157 available PSMA1 gene related products
- Overview of 157 available PSMA1 gene related products
- Applied Biological Materials CRISPR for PSMA1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSMA1
- GenScript: Design CRISPR guide RNA sequences for PSMA1
miRNA Products
- Search ViGene Biosciences for PSMA1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PSMA1
- Browse OriGene Inhibitory RNA Products For PSMA1
- genomics-online: shRNA clones - Search results for 157 available PSMA1 gene related products
- Overview of 157 available PSMA1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PSMA1 gene
Clone Products
-
OriGene ORF clones in human for PSMA1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PSMA1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PSMA1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PSMA1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for PSMA1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | · | 12c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - |
Expression for PSMA1 Gene
This gene is overexpressed in Liver, secretome (7.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSMA1 Gene
NURSA nuclear receptor signaling pathways regulating expression of PSMA1 Gene:
PSMA1SOURCE GeneReport for Unigene cluster for PSMA1 Gene:
Hs.102798Evidence on tissue expression from TISSUES for PSMA1 Gene
- Nervous system(4.9)
- Liver(4.7)
- Bone marrow(4.4)
- Intestine(2.4)
- Lymph node(2.3)
- Thyroid gland(2.3)
- Lung(2.2)
- Muscle(2.2)
- Skin(2.2)
Primer Products
-
OriGene qPCR primer pairs for PSMA1
-
OriGene qPCR primer pairs and template standards for PSMA1
- genomics-online: primer clones - Search results for 157 available PSMA1 gene related products
- Overview of 157 available PSMA1 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMA1 Gene
Orthologs for PSMA1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PSMA1 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| PSMA1 33 |
|
||||
| -- 34 |
|
ManyToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| cow (Bos Taurus) |
Mammalia | PSMA1 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Psma1 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Psma1 33 |
|
||
| chicken (Gallus gallus) |
Aves | PSMA1 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.5957 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | psma1 33 34 |
|
||
| wufc17c09 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8498 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Pros35 35 34 |
|
||
| Prosalpha6T 35 33 34 |
|
||||
| worm (Caenorhabditis elegans) |
Secernentea | pas-6 33 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PRE5 33 34 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0A10153g 33 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AGL336W 33 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | PAF2 33 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.6955 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os02g0133800 33 |
|
||
| barley (Hordeum vulgare) |
Liliopsida | Hv.2240 33 |
|
||
| wheat (Triticum aestivum) |
Liliopsida | Ta.18932 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.5765 34 |
|
OneToMany | |
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC6G10.04c 33 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU06712 33 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.4798 33 |
|
- Species where no ortholog for PSMA1 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Paralogs for PSMA1 Gene
Paralogs for PSMA1 Gene
(7) SIMAP similar genes for PSMA1 Gene using alignment to 4 proteins:
Pseudogenes.org Pseudogenes for PSMA1 Gene
Variants for PSMA1 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000033185 | -- | 14,554,665(-) | T/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000034283 | -- | 14,629,971(-) | T/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000048182 | -- | 14,582,398(-) | A/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000074110 | -- | 14,625,990(-) | A/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000085007 | -- | 14,554,932(-) | C/G/T | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv951312 | CNV | deletion | 24416366 |
| nsv7685 | CNV | insertion | 18451855 |
| nsv518508 | CNV | loss | 19592680 |
| nsv517985 | CNV | loss | 19592680 |
| nsv1048243 | CNV | gain | 25217958 |
| esv3625424 | CNV | loss | 21293372 |
| esv3625423 | CNV | loss | 21293372 |
| esv3578250 | CNV | gain | 25503493 |
| esv3324169 | CNV | insertion | 20981092 |
| esv3305305 | CNV | mobile element insertion | 20981092 |
Residual Variation Intolerance Score:
36.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.79;
16.71% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PSMA1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMA1 Gene
Disorders for PSMA1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| male reproductive organ cancer |
|
|
| farmer's lung |
|
|
| reproductive organ cancer |
|
|
| fanconi anemia, complementation group a |
|
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Search PSMA1 in MalaCards
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Additional Disease Information for PSMA1
No data available for UniProtKB/Swiss-Prot and Genatlas for PSMA1 Gene
Publications for PSMA1 Gene
- Two mRNAs exist for the Hs PROS-30 gene encoding a component of human prosomes. (PMID: 1398136) Silva Pereira I … Scherrer K (Gene 1992) 2 3 4 58
- Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes). (PMID: 2025653) Tamura T … Ichihara A (Biochimica et biophysica acta 1991) 2 3 4 58
- Crystal structure of the human 20S proteasome in complex with carfilzomib. (PMID: 25599644) Harshbarger W … Sacchettini J (Structure (London, England : 1993) 2015) 3 4 58
- Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X … Huang L (Biochemistry 2007) 3 4 58
- Conserved signal peptide of Notch3 inhibits interaction with proteasome. (PMID: 17292860) Zhang Y … Wang MM (Biochemical and biophysical research communications 2007) 3 4 58
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