Aliases for PSKH2 Gene

Aliases for PSKH2 Gene

  • Protein Serine Kinase H2 2 3 4 5
  • Serine/Threonine-Protein Kinase H2 3 4
  • EC 2.7.11.1 4 51
  • Serine/Threonine Kinase PSKH2 3
  • EC 2.7.11 51
  • PSK-H2 4
  • PSKH2 5

External Ids for PSKH2 Gene

Previous GeneCards Identifiers for PSKH2 Gene

  • GC08M085649
  • GC08M086792
  • GC08M087017
  • GC08M087129
  • GC08M082270
  • GC08M087060

Summaries for PSKH2 Gene

GeneCards Summary for PSKH2 Gene

PSKH2 (Protein Serine Kinase H2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PSKH1.

Additional gene information for PSKH2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSKH2 Gene

Genomics for PSKH2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PSKH2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J086088 Enhancer 0.7 Ensembl 600.7 -0.1 -80 0.6 CTCF PRDM10 REST RAD21 TRIM22 CTBP1 ZNF444 OSR2 ZNF592 SMC3 PSKH2 RF00017-7161 ATP6V0D2 SLC7A13
GH08J086086 Enhancer 0.3 Ensembl 600.7 +1.9 1920 0.6 CEBPG CEBPB PSKH2 lnc-WWP1-3 ATP6V0D2
GH08J086033 Enhancer 1.1 FANTOM5 Ensembl dbSUPER 11.5 +53.4 53437 4 CREB1 CTCF JUND PKNOX1 REST RAD21 NFE2 JUN USF1 SMC3 PSKH2 CA2 CA3-AS1 RF00017-7160 RPL32P4 ATP6V0D2
GH08J085999 Enhancer 1 Ensembl ENCODE dbSUPER 11.2 +86.6 86613 4.9 CREB1 ATF7 MNT CEBPB RFX1 CTBP1 FOS CHD2 JUN RCOR1 PSKH2 CA2 CA3-AS1 CA1 piR-38351-466 ATP6V0D2
GH08J086044 Enhancer 0.7 Ensembl ENCODE 11.6 +43.7 43720 1 CTCF ARID3A RAD21 CTBP1 ZNF444 SMC3 CUX1 FOXA1 ZNF654 TRIM22 RPL32P4 lnc-WWP1-3 PSKH2 ATP6V0D2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSKH2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PSKH2

Top Transcription factor binding sites by QIAGEN in the PSKH2 gene promoter:
  • GATA-2
  • Pax-4a
  • POU2F1
  • POU2F1a
  • S8
  • SRF
  • SRF (504 AA)
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for PSKH2 Gene

Genomic Locations for PSKH2 Gene
chr8:86,047,109-86,088,621
(GRCh38/hg38)
Size:
41,513 bases
Orientation:
Minus strand
chr8:87,060,602-87,100,850
(GRCh37/hg19)
Size:
40,249 bases
Orientation:
Minus strand

Genomic View for PSKH2 Gene

Genes around PSKH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSKH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSKH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSKH2 Gene

Proteins for PSKH2 Gene

  • Protein details for PSKH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QS6-KPSH2_HUMAN
    Recommended name:
    Serine/threonine-protein kinase H2
    Protein Accession:
    Q96QS6
    Secondary Accessions:
    • A0AV22

    Protein attributes for PSKH2 Gene

    Size:
    385 amino acids
    Molecular mass:
    43027 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PSKH2 Gene

Selected DME Specific Peptides for PSKH2 Gene

Q96QS6:
  • CGTPEYIAPE
  • YDIKALIG
  • LKPENLLYYHPG
  • VYMVMELATGGELFDR
  • RAKFDPRV
  • GSFTERDA
  • GGELFDR
  • LKPENLL
  • YIAPEVL
  • GSFSRVVRVE

Post-translational modifications for PSKH2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PSKH2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PSKH2 Gene

Gene Families for PSKH2 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for PSKH2 Gene

Suggested Antigen Peptide Sequences for PSKH2 Gene

GenScript: Design optimal peptide antigens:
  • Protein serine kinase H2 (KPSH2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96QS6

UniProtKB/Swiss-Prot:

KPSH2_HUMAN :
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
genes like me logo Genes that share domains with PSKH2: view

Function for PSKH2 Gene

Molecular function for PSKH2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.

Enzyme Numbers (IUBMB) for PSKH2 Gene

Phenotypes From GWAS Catalog for PSKH2 Gene

Gene Ontology (GO) - Molecular Function for PSKH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005515 protein binding IPI 22939624
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PSKH2: view
genes like me logo Genes that share phenotypes with PSKH2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSKH2

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PSKH2 Gene

Localization for PSKH2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSKH2 gene
Compartment Confidence
cytosol 2
mitochondrion 0
nucleus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PSKH2 Gene

Pathways & Interactions for PSKH2 Gene

PathCards logo

SuperPathways for PSKH2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PSKH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with PSKH2: view

No data available for Pathways by source and SIGNOR curated interactions for PSKH2 Gene

Drugs & Compounds for PSKH2 Gene

(1) Drugs for PSKH2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0

(1) Additional Compounds for PSKH2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
genes like me logo Genes that share compounds with PSKH2: view

Transcripts for PSKH2 Gene

mRNA/cDNA for PSKH2 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSKH2

Alternative Splicing Database (ASD) splice patterns (SP) for PSKH2 Gene

No ASD Table

Relevant External Links for PSKH2 Gene

GeneLoc Exon Structure for
PSKH2

Expression for PSKH2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PSKH2 Gene

mRNA differential expression in normal tissues according to GTEx for PSKH2 Gene

This gene is overexpressed in Testis (x21.3), Kidney - Cortex (x17.1), Brain - Putamen (basal ganglia) (x5.2), Brain - Hippocampus (x5.1), and Brain - Hypothalamus (x4.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PSKH2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PSKH2

SOURCE GeneReport for Unigene cluster for PSKH2 Gene:

Hs.680136
genes like me logo Genes that share expression patterns with PSKH2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSKH2 Gene

Orthologs for PSKH2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PSKH2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PSKH2 30 31
  • 98.35 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PSKH2 30 31
  • 86.42 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PSKH2 31
  • 71 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PSKH2 31
  • 68 (a)
OneToOne
Chicken
(Gallus gallus)
Aves -- 31
  • 31 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 35 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100497280 30
  • 67.26 (n)
Zebrafish
(Danio rerio)
Actinopterygii PSKH2 31
  • 46 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea R06A10.4 31 32
  • 36 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CMK1 31
  • 25 (a)
ManyToMany
CMK2 31
  • 24 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 53 (a)
OneToMany
Species where no ortholog for PSKH2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PSKH2 Gene

ENSEMBL:
Gene Tree for PSKH2 (if available)
TreeFam:
Gene Tree for PSKH2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PSKH2: view image

Paralogs for PSKH2 Gene

Variants for PSKH2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PSKH2 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs778066815 A lung adenocarcinoma sample p.Lys212Ile
VAR_040618 A lung adenocarcinoma sample p.Ser116Ile
rs16876805 - p.Ile336Val
rs16879427 - p.Gln132Arg
rs34037815 - p.Ser266Arg

Additional dbSNP identifiers (rs#s) for PSKH2 Gene

Structural Variations from Database of Genomic Variants (DGV) for PSKH2 Gene

Variant ID Type Subtype PubMed ID
esv3391956 CNV insertion 20981092
esv3891432 CNV gain 25118596
nsv1028959 CNV gain 25217958
nsv428204 CNV gain 18775914

Variation tolerance for PSKH2 Gene

Residual Variation Intolerance Score: 93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.35; 76.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PSKH2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSKH2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSKH2 Gene

Disorders for PSKH2 Gene

Additional Disease Information for PSKH2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for PSKH2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSKH2 Gene

Publications for PSKH2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3
  4. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M … Lindquist S (Cell 2014) 3
  5. Identification of synthetic lethality of PRKDC in MYC-dependent human cancers by pooled shRNA screening. (PMID: 25495526) Zhou Z … Liu J (BMC cancer 2014) 3

Products for PSKH2 Gene

Sources for PSKH2 Gene