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Aliases for PSKH2 Gene

Aliases for PSKH2 Gene

  • Protein Serine Kinase H2 2 3 4 5
  • EC 4 56
  • EC 2.7.11 56
  • PSK-H2 4

External Ids for PSKH2 Gene

Previous GeneCards Identifiers for PSKH2 Gene

  • GC08M085649
  • GC08M086792
  • GC08M087017
  • GC08M087129
  • GC08M082270
  • GC08M087060

Summaries for PSKH2 Gene

GeneCards Summary for PSKH2 Gene

PSKH2 (Protein Serine Kinase H2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PSKH1.

Additional gene information for PSKH2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSKH2 Gene

Genomics for PSKH2 Gene

GeneHancer (GH) Regulatory Elements for PSKH2 Gene

Promoters and enhancers for PSKH2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I085999 Enhancer 0.9 ENCODE dbSUPER 11.2 +86.6 86613 4.9 MXI1 PKNOX1 JUN MAX CEBPG RAD21 RFX5 CTBP1 GATA3 RCOR1 PSKH2 CA2 CA3-AS1 CA1 ATP6V0D2 RPL36AP31
GH08I086063 Enhancer 0.6 ENCODE 11.6 +24.9 24872 0.9 MEIS2 PKNOX1 PRDM6 POLR2A GFI1B ZNF384 FEZF1 KDM1A ZIC2 PSKH2 CA2 CA3-AS1 GC08P086044 ATP6V0D2
GH08I086044 Enhancer 0.6 ENCODE 11.6 +44.1 44144 0.1 HDGF CTCF RAD21 FOXA1 CTBP1 ARID3A GATA3 CUX1 ZNF444 GC08P086044 RPL32P4 PSKH2 ATP6V0D2
GH08I086039 Enhancer 0.6 Ensembl ENCODE dbSUPER 11.6 +49.0 49020 0.8 PSKH2 LOC105375624 WWP1 CA3-AS1 CA2 RPL32P4 GC08P086017 ATP6V0D2
GH08I086033 Enhancer 0.6 Ensembl dbSUPER 11.5 +54.6 54620 0.4 CTCF MYC PSKH2 CA2 CA3-AS1 RPL32P4 GC08P086017 ATP6V0D2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PSKH2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PSKH2 gene promoter:

Genomic Locations for PSKH2 Gene

Genomic Locations for PSKH2 Gene
41,513 bases
Minus strand

Genomic View for PSKH2 Gene

Genes around PSKH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSKH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSKH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSKH2 Gene

Proteins for PSKH2 Gene

  • Protein details for PSKH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein kinase H2
    Protein Accession:
    Secondary Accessions:
    • A0AV22

    Protein attributes for PSKH2 Gene

    385 amino acids
    Molecular mass:
    43027 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PSKH2 Gene

Selected DME Specific Peptides for PSKH2 Gene


Post-translational modifications for PSKH2 Gene

No Post-translational modifications

Other Protein References for PSKH2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PSKH2 Gene

Gene Families for PSKH2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for PSKH2 Gene

Suggested Antigen Peptide Sequences for PSKH2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
genes like me logo Genes that share domains with PSKH2: view

Function for PSKH2 Gene

Molecular function for PSKH2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for PSKH2 Gene

Gene Ontology (GO) - Molecular Function for PSKH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with PSKH2: view
genes like me logo Genes that share phenotypes with PSKH2: view

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PSKH2 Gene

Localization for PSKH2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSKH2 gene
Compartment Confidence
cytosol 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PSKH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
genes like me logo Genes that share ontologies with PSKH2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for PSKH2 Gene

Pathways & Interactions for PSKH2 Gene

SuperPathways for PSKH2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PSKH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
GO:0018105 peptidyl-serine phosphorylation IBA --
GO:0018107 peptidyl-threonine phosphorylation IBA --
GO:0035556 intracellular signal transduction IBA --
genes like me logo Genes that share ontologies with PSKH2: view

No data available for Pathways by source and SIGNOR curated interactions for PSKH2 Gene

Drugs & Compounds for PSKH2 Gene

(1) Drugs for PSKH2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist 0

(1) Additional Compounds for PSKH2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with PSKH2: view

Transcripts for PSKH2 Gene

mRNA/cDNA for PSKH2 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PSKH2 Gene

Protein serine kinase H2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSKH2 Gene

No ASD Table

Relevant External Links for PSKH2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PSKH2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSKH2 Gene

mRNA differential expression in normal tissues according to GTEx for PSKH2 Gene

This gene is overexpressed in Testis (x21.3), Kidney - Cortex (x17.1), Brain - Putamen (basal ganglia) (x5.2), Brain - Hippocampus (x5.1), and Brain - Hypothalamus (x4.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PSKH2 Gene

NURSA nuclear receptor signaling pathways regulating expression of PSKH2 Gene:


SOURCE GeneReport for Unigene cluster for PSKH2 Gene:

genes like me logo Genes that share expression patterns with PSKH2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSKH2 Gene

Orthologs for PSKH2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PSKH2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PSKH2 33 34
  • 98.35 (n)
(Canis familiaris)
Mammalia PSKH2 33 34
  • 86.42 (n)
(Ornithorhynchus anatinus)
Mammalia PSKH2 34
  • 71 (a)
(Monodelphis domestica)
Mammalia PSKH2 34
  • 68 (a)
(Gallus gallus)
Aves -- 34
  • 31 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 35 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497280 33
  • 67.26 (n)
(Danio rerio)
Actinopterygii PSKH2 34
  • 46 (a)
(Caenorhabditis elegans)
Secernentea R06A10.4 35 34
  • 44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CMK1 34
  • 25 (a)
CMK2 34
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 53 (a)
Species where no ortholog for PSKH2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSKH2 Gene

Gene Tree for PSKH2 (if available)
Gene Tree for PSKH2 (if available)

Paralogs for PSKH2 Gene

Variants for PSKH2 Gene

Sequence variations from dbSNP and Humsavar for PSKH2 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs778066815 A lung adenocarcinoma sample 86,064,182(-) T/A coding_sequence_variant, missense_variant
VAR_040618 A lung adenocarcinoma sample p.Ser116Ile
rs1000291223 -- 86,071,399(-) A/G upstream_transcript_variant
rs1000317238 -- 86,065,773(-) G/A intron_variant
rs1000500098 -- 86,055,028(-) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PSKH2 Gene

Variant ID Type Subtype PubMed ID
esv3391956 CNV insertion 20981092
esv3891432 CNV gain 25118596
nsv1028959 CNV gain 25217958
nsv428204 CNV gain 18775914

Variation tolerance for PSKH2 Gene

Residual Variation Intolerance Score: 93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.35; 76.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PSKH2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSKH2 Gene

Disorders for PSKH2 Gene

Additional Disease Information for PSKH2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PSKH2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSKH2 Gene

Publications for PSKH2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  4. Identification of synthetic lethality of PRKDC in MYC-dependent human cancers by pooled shRNA screening. (PMID: 25495526) Zhou Z … Liu J (BMC cancer 2014) 3 58
  5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M … Lindquist S (Cell 2012) 3 58

Products for PSKH2 Gene

Sources for PSKH2 Gene

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