The protein encoded by this gene is a member of the pregnancy-specific glycoprotein (PSG) family. This protein family and the closely related carcinoembryonic antigen cell adhesion molecule (CEACAM) gene family are both members of the immunoglobulin superfamily, and are organized as a large gene cluster. This protein is thought to inhibit platelet-fibrinogen interactions. Sever... See more...

Aliases for PSG9 Gene

Aliases for PSG9 Gene

  • Pregnancy Specific Beta-1-Glycoprotein 9 2 3 5
  • Pregnancy-Specific Beta-1-Glycoprotein 9 3 4
  • Pregnancy-Specific Beta-1 Glycoprotein B 3 4
  • PS-Beta-G-11 3 4
  • PS-Beta-G-9 3 4
  • PS-Beta-B 3 4
  • PSBG-11 3 4
  • PSBG-9 3 4
  • PSG11 3 4
  • PSGII 2 3
  • PS34 3 4
  • Pregnancy-Specific Beta-1-Glycoprotein 11 C-R Domain 3
  • Pregnancy Specific Beta-1-Glycoprotein 11 3
  • Pregnancy-Specific Beta-1-Glycoprotein 11 4
  • Pregnancy-Specific Glycoprotein 11 4
  • Pregnancy-Specific Glycoprotein 9 4
  • Pregnancy-Specific Glycoprotein 7 4
  • PSG9 5
  • PSG7 4

External Ids for PSG9 Gene

Previous HGNC Symbols for PSG9 Gene

  • PSG11

Previous GeneCards Identifiers for PSG9 Gene

  • GC19M044404
  • GC19M044089
  • GC19M048433
  • GC19M048449
  • GC19M043717
  • GC19M043718
  • GC19M040187
  • GC19M043757
  • GC19M043212

Summaries for PSG9 Gene

Entrez Gene Summary for PSG9 Gene

  • The protein encoded by this gene is a member of the pregnancy-specific glycoprotein (PSG) family. This protein family and the closely related carcinoembryonic antigen cell adhesion molecule (CEACAM) gene family are both members of the immunoglobulin superfamily, and are organized as a large gene cluster. This protein is thought to inhibit platelet-fibrinogen interactions. Several studies suggest that reduced serum concentrations of PSGs are associated with fetal growth restrictions, while up-regulation of this gene has been observed in colorectal cancers. Several pseudogenes of this gene are found on chromosome 19. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms. [provided by RefSeq, Sep 2014]

GeneCards Summary for PSG9 Gene

PSG9 (Pregnancy Specific Beta-1-Glycoprotein 9) is a Protein Coding gene. Diseases associated with PSG9 include Trachea Carcinoma and Compensatory Emphysema. Among its related pathways are Cell surface interactions at the vascular wall and Response to elevated platelet cytosolic Ca2+. An important paralog of this gene is PSG6.

Gene Wiki entry for PSG9 Gene

Additional gene information for PSG9 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSG9 Gene

Genomics for PSG9 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PSG9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J043263 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 600.7 +2.8 2830 5.8 CREB1 PRDM10 ZNF629 ZNF692 PRDM1 ZSCAN4 PATZ1 ZNF501 ZNF600 ATF7 PSG9 CD177 PSG4 LOC100505715 MEGF8 ZNF428 ZNF575 ENSG00000186019 ZNF404 ZNF576
GH19J043250 Enhancer 0.5 Ensembl 0.4 +19.1 19129 0.4 BCL11A ZBTB48 ZBTB17 ZNF335 FOXA1 ZNF366 GLIS1 ZSCAN21 CEACAMP10 PSG4 ENSG00000231412 LOC284344 PSG9
GH19J043251 Enhancer 0.5 Ensembl 0.4 +18.6 18629 0.2 PRDM10 ZNF174 ZNF335 FOXA1 ZNF366 ZFP37 XRCC1 ZNF227 ZNF45 ZNF225 CIC ZNF155 PSG4 CEACAMP10 LOC284344 PSG9
GH19J043248 Enhancer 0.4 Ensembl 0.4 +20.5 20530 1.2 PRDM1 GLI4 ZNF24 BCL6B CEACAMP10 piR-46002-299 PSG4 ENSG00000231412 LOC284344 PSG9
GH19J043332 Enhancer 0.7 ENCODE 0.2 -63.4 -63390 1.5 CTCF ZSCAN4 ZNF747 CTBP1 ZBTB10 ZNF138 NR2F2 RAD21 SMC3 ELF1 ENSG00000231412 ZNF225 ZNF45 ZNF284 ZNF226 ZNF235 ZNF224 ZNF234 ZNF223 ZNF227
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSG9 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PSG9

Top Transcription factor binding sites by QIAGEN in the PSG9 gene promoter:
  • AREB6
  • c-Myb
  • POU3F1
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • PPAR-gamma1
  • PPAR-gamma2
  • RORalpha2

Genomic Locations for PSG9 Gene

Genomic Locations for PSG9 Gene
chr19:43,211,791-43,269,530
(GRCh38/hg38)
Size:
57,740 bases
Orientation:
Minus strand
chr19:43,715,943-43,773,682
(GRCh37/hg19)
Size:
57,740 bases
Orientation:
Minus strand

Genomic View for PSG9 Gene

Genes around PSG9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSG9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSG9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSG9 Gene

Proteins for PSG9 Gene

  • Protein details for PSG9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00887-PSG9_HUMAN
    Recommended name:
    Pregnancy-specific beta-1-glycoprotein 9
    Protein Accession:
    Q00887
    Secondary Accessions:
    • B2R869
    • Q15227
    • Q15236
    • Q15237
    • Q8WW78
    • Q9UQ73

    Protein attributes for PSG9 Gene

    Size:
    426 amino acids
    Molecular mass:
    48272 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PSG9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSG9 Gene

Post-translational modifications for PSG9 Gene

  • Glycosylation at Asn104, Asn111, Asn199, Asn268, Asn387, and Asn303
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PSG9 Gene

Domains & Families for PSG9 Gene

Gene Families for PSG9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for PSG9 Gene

InterPro:
Blocks:
  • Immunoglobulin C-2 type
  • Immunoglobulin V-set
ProtoNet:

Suggested Antigen Peptide Sequences for PSG9 Gene

GenScript: Design optimal peptide antigens:
  • Pregnancy-specific glycoprotein 7 (PSG9_HUMAN)
  • PSG9 protein (Q05DN5_HUMAN)
  • Pregnancy-specific beta-1-glycoprotein (Q12811_HUMAN)
  • PSG9 protein (Q6LEU7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q00887

UniProtKB/Swiss-Prot:

PSG9_HUMAN :
  • Belongs to the immunoglobulin superfamily. CEA family.
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with PSG9: view

Function for PSG9 Gene

Molecular function for PSG9 Gene

GENATLAS Biochemistry:
pregnancy specific beta-1-glycoprotein 9,expressed by placental syncytiotrophoblasts,unknown function,carcinoembryonic antigen (CEA family),immunoglobulin superfamily

Phenotypes From GWAS Catalog for PSG9 Gene

Phenotypes for PSG9 Gene

genes like me logo Genes that share phenotypes with PSG9: view

Animal Model Products

CRISPR Products

miRNA for PSG9 Gene

miRTarBase miRNAs that target PSG9

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSG9

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSG9 Gene

Localization for PSG9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSG9 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSG9 gene
Compartment Confidence
extracellular 4
plasma membrane 2
mitochondrion 2
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PSG9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PSG9: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PSG9 Gene

Pathways & Interactions for PSG9 Gene

genes like me logo Genes that share pathways with PSG9: view

Pathways by source for PSG9 Gene

Gene Ontology (GO) - Biological Process for PSG9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007565 female pregnancy TAS 1922019
genes like me logo Genes that share ontologies with PSG9: view

No data available for SIGNOR curated interactions for PSG9 Gene

Drugs & Compounds for PSG9 Gene

No Compound Related Data Available

Transcripts for PSG9 Gene

mRNA/cDNA for PSG9 Gene

4 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSG9

Alternative Splicing Database (ASD) splice patterns (SP) for PSG9 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
SP1: -
SP2: - -
SP3: - - -
SP4: - - - -

Relevant External Links for PSG9 Gene

GeneLoc Exon Structure for
PSG9

Expression for PSG9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PSG9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PSG9 Gene

This gene is overexpressed in Testis (x7.4).

Protein differential expression in normal tissues from HIPED for PSG9 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PSG9 Gene



Protein tissue co-expression partners for PSG9 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PSG9

SOURCE GeneReport for Unigene cluster for PSG9 Gene:

Hs.502092

Evidence on tissue expression from TISSUES for PSG9 Gene

  • Blood(4.3)
genes like me logo Genes that share expression patterns with PSG9: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSG9 Gene

Orthologs for PSG9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PSG9 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PSG9 30 31
  • 96.86 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CEACAM1 31
  • 34 (a)
ManyToMany
-- 31
  • 25 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 23 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Psg23 31
  • 22 (a)
ManyToMany
Species where no ortholog for PSG9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for PSG9 Gene

ENSEMBL:
Gene Tree for PSG9 (if available)
TreeFam:
Gene Tree for PSG9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PSG9: view image

Paralogs for PSG9 Gene

(25) SIMAP similar genes for PSG9 Gene using alignment to 8 proteins:

  • PSG9_HUMAN
  • E7EW65_HUMAN
  • G3XAA7_HUMAN
  • H7C1I4_HUMAN
  • M0R0E4_HUMAN
  • M0R0U8_HUMAN
  • Q05DN5_HUMAN
  • Q6LEU7_HUMAN
genes like me logo Genes that share paralogs with PSG9: view

Variants for PSG9 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PSG9 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
770286 Benign: not provided 43,258,277(-) C/T MISSENSE_VARIANT
rs1058085 - p.Ala176Thr
rs1135905 - p.Ile325Thr
rs2072285 - p.His397Arg
rs2074923 - p.Gln374Leu

Additional dbSNP identifiers (rs#s) for PSG9 Gene

Structural Variations from Database of Genomic Variants (DGV) for PSG9 Gene

Variant ID Type Subtype PubMed ID
dgv140e55 CNV gain 17911159
dgv143n111 CNV deletion 26073780
dgv146n111 CNV deletion 26073780
dgv3566n100 CNV gain 25217958
dgv3572n100 CNV gain+loss 25217958
dgv3577n100 CNV gain 25217958
dgv3583n100 CNV loss 25217958
dgv3585n100 CNV loss 25217958
dgv3587n100 CNV gain 25217958
dgv3591n100 CNV loss 25217958
dgv3592n100 CNV loss 25217958
dgv3595n100 CNV gain 25217958
dgv3599n100 CNV loss 25217958
dgv3601n100 CNV gain 25217958
dgv3602n100 CNV loss 25217958
dgv411n27 CNV loss 19166990
dgv523e201 CNV deletion 23290073
dgv524e201 CNV deletion 23290073
dgv525e201 CNV deletion 23290073
dgv590n67 CNV loss 20364138
dgv645e199 CNV deletion 23128226
dgv6466n54 CNV gain 21841781
dgv6471n54 CNV loss 21841781
dgv6495n54 CNV gain+loss 21841781
dgv6496n54 CNV loss 21841781
dgv6497n54 CNV loss 21841781
dgv6498n54 CNV loss 21841781
dgv6499n54 CNV loss 21841781
dgv6500n54 CNV loss 21841781
dgv662e214 CNV loss 21293372
dgv73e203 CNV gain+loss 21179565
esv1002165 CNV gain 20482838
esv22277 CNV gain+loss 19812545
esv2663048 CNV deletion 23128226
esv2671292 CNV deletion 23128226
esv2675877 CNV deletion 23128226
esv2718603 CNV deletion 23290073
esv2718609 CNV deletion 23290073
esv2751795 CNV loss 17911159
esv2758763 CNV gain+loss 17122850
esv33039 CNV gain 17666407
esv34676 CNV loss 17911159
esv3556434 CNV deletion 23714750
esv3644411 CNV loss 21293372
esv3644450 CNV loss 21293372
esv3644457 CNV loss 21293372
esv3644459 CNV loss 21293372
esv3644460 CNV gain 21293372
esv3893216 CNV gain+loss 25118596
esv3893217 CNV gain 25118596
esv6630 CNV loss 19470904
nsv1057657 CNV gain 25217958
nsv1057682 CNV loss 25217958
nsv1072885 CNV deletion 25765185
nsv1133452 CNV deletion 24896259
nsv1140446 CNV deletion 24896259
nsv1153047 CNV deletion 26484159
nsv1160646 CNV deletion 26073780
nsv1160647 CNV deletion 26073780
nsv2499 CNV deletion 18451855
nsv435702 CNV deletion 17901297
nsv436856 CNV insertion 17901297
nsv437832 CNV loss 16327808
nsv437833 CNV loss 16327808
nsv458705 CNV loss 19166990
nsv469787 CNV loss 16826518
nsv470145 CNV loss 18288195
nsv471414 CNV gain 19718026
nsv482045 CNV gain 20164927
nsv511618 CNV loss 21212237
nsv516973 CNV gain+loss 19592680
nsv579759 CNV loss 21841781
nsv579779 CNV loss 21841781
nsv579809 CNV gain 21841781
nsv579820 CNV loss 21841781
nsv579831 CNV loss 21841781
nsv579832 CNV loss 21841781
nsv817848 CNV loss 17921354
nsv820547 CNV deletion 20802225
nsv963056 CNV duplication 23825009
nsv9730 CNV gain+loss 18304495

Variation tolerance for PSG9 Gene

Residual Variation Intolerance Score: 99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.01; 84.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PSG9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSG9

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSG9 Gene

Disorders for PSG9 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PSG9 Gene - From: DISEASES

Disorder Aliases PubMed IDs
trachea carcinoma
  • carcinoma of the trachea
compensatory emphysema
- elite association - COSMIC cancer census association via MalaCards
Search PSG9 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with PSG9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSG9 Gene

Publications for PSG9 Gene

  1. Characterization of the PSG11 gene. (PMID: 7806221) McLenachan PA … Mansfield BC (Genomics 1994) 2 3 4 23
  2. Identification of a new carcinoembryonic antigen (CEA) family member in human fetal liver--cloning and sequence determination of pregnancy-specific glycoprotein 7. (PMID: 2328001) Khan WN … Hammarström S (Biochemical and biophysical research communications 1990) 3 4 23
  3. Differential gene expression profile reveals deregulation of pregnancy specific beta1 glycoprotein 9 early during colorectal carcinogenesis. (PMID: 15982419) Salahshor S … Woodgett JR (BMC cancer 2005) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4

Products for PSG9 Gene

  • Signalway ELISA kits for PSG9
  • Signalway Proteins for PSG9

Sources for PSG9 Gene