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The protein encoded by this gene is a member of the pregnancy-specific glycoprotein (PSG) family. This protein family and the closely related carcinoembryonic antigen cell adhesion molecule (CEACAM) gene family are both members of the immunoglobulin superfamily, and are organized as a large gene cluster. This protein is thought to inhibit platelet-fibrinogen interactions. Sever... See more...
Aliases for PSG9 Gene
Aliases for PSG9 Gene
External Ids for PSG9 Gene
- HGNC: 9526
- Entrez Gene: 5678
- Ensembl: ENSG00000183668
- OMIM: 176398
- UniProtKB: Q00887
Previous HGNC Symbols for PSG9 Gene
- PSG11
Previous GeneCards Identifiers for PSG9 Gene
- GC19M044404
- GC19M044089
- GC19M048433
- GC19M048449
- GC19M043717
- GC19M043718
- GC19M040187
- GC19M043757
- GC19M043212
Summaries for PSG9 Gene
-
The protein encoded by this gene is a member of the pregnancy-specific glycoprotein (PSG) family. This protein family and the closely related carcinoembryonic antigen cell adhesion molecule (CEACAM) gene family are both members of the immunoglobulin superfamily, and are organized as a large gene cluster. This protein is thought to inhibit platelet-fibrinogen interactions. Several studies suggest that reduced serum concentrations of PSGs are associated with fetal growth restrictions, while up-regulation of this gene has been observed in colorectal cancers. Several pseudogenes of this gene are found on chromosome 19. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms. [provided by RefSeq, Sep 2014]
GeneCards Summary for PSG9 Gene
PSG9 (Pregnancy Specific Beta-1-Glycoprotein 9) is a Protein Coding gene. Diseases associated with PSG9 include Trachea Carcinoma and Compensatory Emphysema. Among its related pathways are Cell surface interactions at the vascular wall and Response to elevated platelet cytosolic Ca2+. An important paralog of this gene is PSG6.
Additional gene information for PSG9 Gene
- HGNC(9526)
- Entrez Gene(5678)
- Ensembl(ENSG00000183668)
- OMIM(176398)
- UniProtKB(Q00887)
- Open Targets Platform(ENSG00000183668)
- Search for PSG9 at DataMed
- Search for PSG9 at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSG9 Gene
Genomics for PSG9 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PSG9 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PSG9 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PSG9
- Top Transcription factor binding sites by QIAGEN in the PSG9 gene promoter:
-
- AREB6
- c-Myb
- POU3F1
- POU3F2
- POU3F2 (N-Oct-5a)
- POU3F2 (N-Oct-5b)
- PPAR-gamma1
- PPAR-gamma2
- RORalpha2
Genomic Locations for PSG9 Gene
Genomic Locations for PSG9 Gene
- chr19:43,211,791-43,269,530
- (GRCh38/hg38)
- Size:
- 57,740 bases
- Orientation:
- Minus strand
- chr19:43,715,943-43,773,682
- (GRCh37/hg19)
- Size:
- 57,740 bases
- Orientation:
- Minus strand
Genomic View for PSG9 Gene
Genes around PSG9 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.31 by HGNC
- 19q13.31 by Entrez Gene
- 19q13.31 by Ensembl
PSG9 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PSG9 Gene
Proteins for PSG9 Gene
-
Protein details for PSG9 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q00887-PSG9_HUMAN
- Recommended name:
- Pregnancy-specific beta-1-glycoprotein 9
- Protein Accession:
- Q00887
- B2R869
- Q15227
- Q15236
- Q15237
- Q8WW78
- Q9UQ73
Protein attributes for PSG9 Gene
- Size:
- 426 amino acids
- Molecular mass:
- 48272 Da
- Quaternary structure:
- No Data Available
Protein Expression for PSG9 Gene
Post-translational modifications for PSG9 Gene
Other Protein References for PSG9 Gene
Antibody Products
- LifeSpan BioSciences PSG9 Antibody
-
Custom Antibody ServicesOriGene Antibodies for PSG9
- Novus Biologicals Antibodies for PSG9
-
Abcam antibodies for PSG9
- Invitrogen Antibodies for PSG9 (AFLGC-PSG9)
-
Biorbyt antibodies for PSG9
-
Custom Antibody ServicesProSci Antibodies for PSG9
Protein Products
- G Biosciences Human PSG9/PSG11, Liquid
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for PSG9
- Origene Custom Protein Services for PSG9
- antibodies-online: Show 4 available PSG9 Proteins ranked by validation data
- Compare Top PSG9 Proteins
-
Quality Products:
-
Signalway Proteins for PSG9
-
ProSci Proteins for PSG9
-
Abcam proteins for PSG9
Assay Products
- antibodies-online: Show 1 available PSG9 Elisa Kits ranked by validation data
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-
Quality Products:
-
Signalway ELISA kits for PSG9
No data available for DME Specific Peptides for PSG9 Gene
Domains & Families for PSG9 Gene
Gene Families for PSG9 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for PSG9 Gene
- InterPro:
- Blocks:
-
- Immunoglobulin C-2 type
- Immunoglobulin V-set
- ProtoNet:
Suggested Antigen Peptide Sequences for PSG9 Gene
- GenScript: Design optimal peptide antigens:
-
- Pregnancy-specific glycoprotein 7 (PSG9_HUMAN)
- PSG9 protein (Q05DN5_HUMAN)
- Pregnancy-specific beta-1-glycoprotein (Q12811_HUMAN)
- PSG9 protein (Q6LEU7_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q00887- Family:
-
- Belongs to the immunoglobulin superfamily. CEA family.
Function for PSG9 Gene
Molecular function for PSG9 Gene
- GENATLAS Biochemistry:
- pregnancy specific beta-1-glycoprotein 9,expressed by placental syncytiotrophoblasts,unknown function,carcinoembryonic antigen (CEA family),immunoglobulin superfamily
Phenotypes From GWAS Catalog for PSG9 Gene
Phenotypes for PSG9 Gene
- GenomeRNAi human phenotypes for PSG9:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PSG9 - Select products 50% OFF >
- * PSG9 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
OriGene CRISPR knockouts for PSG9
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-
Santa Cruz Biotechnology (SCBT) CRISPR for PSG9
miRNA for PSG9 Gene
- miRTarBase miRNAs that target PSG9
miRNA Products
Inhibitory RNA Products
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Clone Products
- Applied Biological Materials (abm): Clones for PSG9 - Select products 50% OFF >
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- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PSG9
Cell Line Products
-
Horizon Cell Lines for PSG9
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSG9 Gene
Localization for PSG9 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PSG9 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 4 |
| plasma membrane | 2 |
| mitochondrion | 2 |
| cytoskeleton | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PSG9 Gene
Pathways & Interactions for PSG9 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cell surface interactions at the vascular wall | ||
| 2 | Response to elevated platelet cytosolic Ca2+ |
.44
|
|
Pathways by source for PSG9 Gene
2 Reactome pathways for PSG9 Gene
Interacting Proteins for PSG9 Gene
GPS-Prot Interaction Network for PSG9
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007565 | female pregnancy | TAS | 1922019 |
No data available for SIGNOR curated interactions for PSG9 Gene
Drugs & Compounds for PSG9 Gene
No Compound Related Data Available
Drug Products
- G Biosciences Human PSG9/PSG11, Liquid
Transcripts for PSG9 Gene
mRNA/cDNA for PSG9 Gene
- 4 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000244293 2073 nts (view in UCSC)
- ENST00000270077 1707 nts (view in UCSC)
- ENST00000291752 1055 nts (view in UCSC)
- ENST00000418820 1748 nts (view in UCSC)
- ENST00000443718 1421 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PSG9 - Select products 50% OFF >
- * PSG9 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PSG9
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PSG9
-
Santa Cruz Biotechnology (SCBT) CRISPR for PSG9
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PSG9
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Clone Products
- Applied Biological Materials (abm): Clones for PSG9 - Select products 50% OFF >
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PSG9
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||
| SP4: | - | - | - | - |
Relevant External Links for PSG9 Gene
- GeneLoc Exon Structure for
- PSG9
Expression for PSG9 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Fibroblasts (Uncategorized)
- Dermis (Integumentary System)
-
Placenta (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for PSG9 Gene
This gene is overexpressed in Testis (x7.4).
This gene is overexpressed in Placenta (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PSG9 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PSG9
SOURCE GeneReport for Unigene cluster for PSG9 Gene:
Hs.502092Evidence on tissue expression from TISSUES for PSG9 Gene
- Blood(4.3)
Primer Products
-
OriGene qPCR primer pairs for PSG9
-
OriGene qPCR primer pairs and template standards for PSG9
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSG9 Gene
Orthologs for PSG9 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PSG9 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CEACAM1 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
| Mouse (Mus musculus) |
Mammalia | Psg23 31 |
|
ManyToMany |
- Species where no ortholog for PSG9 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- Dog (Canis familiaris)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for PSG9 Gene
- ENSEMBL:
- Gene Tree for PSG9 (if available)
- TreeFam:
- Gene Tree for PSG9 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PSG9: view image
Paralogs for PSG9 Gene
Paralogs for PSG9 Gene
(25) SIMAP similar genes for PSG9 Gene using alignment to 8 proteins:
- PSG9_HUMAN
- E7EW65_HUMAN
- G3XAA7_HUMAN
- H7C1I4_HUMAN
- M0R0E4_HUMAN
- M0R0U8_HUMAN
- Q05DN5_HUMAN
- Q6LEU7_HUMAN
Pseudogenes.org Pseudogenes for PSG9 Gene
Variants for PSG9 Gene
Residual Variation Intolerance Score:
99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.01;
84.18% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PSG9 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PSG9
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSG9 Gene
Disorders for PSG9 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| trachea carcinoma |
|
|
| compensatory emphysema |
|
|
Search PSG9 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PSG9
No data available for UniProtKB/Swiss-Prot and Genatlas for PSG9 Gene
Publications for PSG9 Gene
- Characterization of the PSG11 gene. (PMID: 7806221) McLenachan PA … Mansfield BC (Genomics 1994) 2 3 4 23
- Identification of a new carcinoembryonic antigen (CEA) family member in human fetal liver--cloning and sequence determination of pregnancy-specific glycoprotein 7. (PMID: 2328001) Khan WN … Hammarström S (Biochemical and biophysical research communications 1990) 3 4 23
- Differential gene expression profile reveals deregulation of pregnancy specific beta1 glycoprotein 9 early during colorectal carcinogenesis. (PMID: 15982419) Salahshor S … Woodgett JR (BMC cancer 2005) 3 23
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4
ExternalLinks
Products for PSG9 Gene
- Custom Antibody ServicesOriGene Antibodies for PSG9
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- OriGene qPCR primer pairs for PSG9
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- Novus Biologicals proteins and lysates for PSG9
- Browse Antibodies
- Browse Peptides and Proteins
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- Abcam antibodies for PSG9
- Abcam proteins for PSG9
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- Browse Primary Antibodies
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- Invitrogen Antibodies for PSG9 (AFLGC-PSG9)
- VectorBuilder Custom and pre-made DNA vectors for PSG9 (ie. gene expression, shRNA knockdown, CRISPR)
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- VectorBuilder Stable cell line generation for PSG9
- antibodies-online: Show 26 available PSG9 Antibodies ranked by validation data
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- Quality Products:
- antibodies-online: Show 4 available PSG9 Proteins ranked by validation data
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- Quality Products:
- Custom Antibody ServicesProSci Antibodies for PSG9
- ProSci Proteins for PSG9
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- Browse GeneCopoeia Cell Lines
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- Biorbyt antibodies for PSG9
Sources for PSG9 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
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- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
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- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
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- (143) Applied Biosystems
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- (146) GeneCopoeia
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- (148) RNACentral
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- (154) Biorbyt
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- (156) Mastermind
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- (159) GeneImprint
- (160) Synthego
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- (163) LncBase
- (164) LncBook
- (165) LNCipedia
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- (178) MirGeneDB