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Aliases for PSG8 Gene

Aliases for PSG8 Gene

  • Pregnancy Specific Beta-1-Glycoprotein 8 2 3 5
  • Pregnancy-Specific Beta-1-Glycoprotein 8 3 4
  • Pregnancy-Specific Glycoprotein 8 3 4
  • PS-Beta-G-8 3 4
  • PSBG-8 3 4
  • Pregnancy-Specific Beta-1 Glycoprotein 3
  • C1 Alternate 3
  • C2 Alternate 3
  • C3 Alternate 3
  • PSG1 3

External Ids for PSG8 Gene

Previous GeneCards Identifiers for PSG8 Gene

  • GC19M043903
  • GC19M043659
  • GC19U900317
  • GC19M047919
  • GC19M047949
  • GC19M043256
  • GC19M039686

Summaries for PSG8 Gene

Entrez Gene Summary for PSG8 Gene

  • The human pregnancy-specific glycoproteins (PSGs) are a group of molecules that are mainly produced by the placental syncytiotrophoblasts during pregnancy. PSGs comprise a subgroup of the carcinoembryonic antigen (CEA) family, which belongs to the immunoglobulin superfamily. For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]

GeneCards Summary for PSG8 Gene

PSG8 (Pregnancy Specific Beta-1-Glycoprotein 8) is a Protein Coding gene. Among its related pathways are Cell surface interactions at the vascular wall and Response to elevated platelet cytosolic Ca2+. An important paralog of this gene is PSG1.

Additional gene information for PSG8 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSG8 Gene

Genomics for PSG8 Gene

GeneHancer (GH) Regulatory Elements for PSG8 Gene

Promoters and enhancers for PSG8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J042765 Promoter 0.5 EPDnew 600.2 +90.0 89993 0.1 PSG8 GC19M042749 PSG3
GH19J042760 Enhancer 1.2 FANTOM5 Ensembl ENCODE 15.9 +93.8 93820 3.5 ZSCAN21 GLIS2 CREB1 ZNF629 ZNF692 JUN JUND ZEB1 ZBTB48 BCL11A PSG8 PSG5 CEACAM1 GC19M042749 PSG3
GH19J042440 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.1 +412.4 412446 5.9 CTCF ELF3 CEBPG ZSCAN21 TFE3 SP1 PPARG CREM ZNF644 EGR1 CXCL17 ZNF574 ZNF526 LIPE-AS1 CNFN PSG8 ENSG00000268355 CD177 PIR51613
GH19J042735 Enhancer 0.8 Ensembl ENCODE 10.4 +118.8 118790 3 CEBPB ZBTB10 RAD51 USF2 ZFP69B ZNF366 ZBTB21 ZNF362 PSG8 PSG3 PIR38528
GH19J042449 Enhancer 1.5 FANTOM5 ENCODE dbSUPER 5.1 +405.4 405362 1.7 SP1 ZFX CC2D1A CTCF ELF3 CEBPG BACH1 TFE3 SP7 ELF1 LIPE ZNF526 RNU4-60P PSG8 CD177 CEACAM1 CXCL17 PIR51613 LIPE-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSG8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PSG8 gene promoter:
  • Ik-1
  • NCX
  • p300
  • PPAR-alpha
  • RORalpha2

Genomic Locations for PSG8 Gene

Genomic Locations for PSG8 Gene
chr19:42,752,686-42,855,691
(GRCh38/hg38)
Size:
103,006 bases
Orientation:
Minus strand
chr19:43,256,838-43,359,843
(GRCh37/hg19)
Size:
103,006 bases
Orientation:
Minus strand

Genomic View for PSG8 Gene

Genes around PSG8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSG8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSG8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSG8 Gene

Proteins for PSG8 Gene

  • Protein details for PSG8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UQ74-PSG8_HUMAN
    Recommended name:
    Pregnancy-specific beta-1-glycoprotein 8
    Protein Accession:
    Q9UQ74
    Secondary Accessions:
    • A5PKV3
    • B2RPL4
    • B4DTI6
    • O60410
    • Q68CR6

    Protein attributes for PSG8 Gene

    Size:
    426 amino acids
    Molecular mass:
    47772 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PSG8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSG8 Gene

Post-translational modifications for PSG8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PSG8 Gene

Domains & Families for PSG8 Gene

Gene Families for PSG8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for PSG8 Gene

GenScript: Design optimal peptide antigens:
  • PSG8 protein (A5PKV3_HUMAN)
  • Pregnancy-specific beta-1-glycoprotein 8 (PSG8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UQ74

UniProtKB/Swiss-Prot:

PSG8_HUMAN :
  • Belongs to the immunoglobulin superfamily. CEA family.
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with PSG8: view

Function for PSG8 Gene

Molecular function for PSG8 Gene

GENATLAS Biochemistry:
pregnancy specific beta-1-glycoprotein 8,expressed by placental syncytiotrophoblasts,unknown function,carcinoembryonic antigen (CEA family),immunoglobulin superfamily
genes like me logo Genes that share phenotypes with PSG8: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSG8

Clone Products

  • Applied Biological Materials (abm): Clones for PSG8 - Now 50% OFF >
  • * PSG8 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * PSG8 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PSG8 Gene

Localization for PSG8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSG8 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSG8 gene
Compartment Confidence
extracellular 3
plasma membrane 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for PSG8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PSG8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PSG8 Gene

Pathways & Interactions for PSG8 Gene

genes like me logo Genes that share pathways with PSG8: view

Pathways by source for PSG8 Gene

Interacting Proteins for PSG8 Gene

Gene Ontology (GO) - Biological Process for PSG8 Gene

None

No data available for SIGNOR curated interactions for PSG8 Gene

Drugs & Compounds for PSG8 Gene

No Compound Related Data Available

Transcripts for PSG8 Gene

Unigene Clusters for PSG8 Gene

Pregnancy specific beta-1-glycoprotein 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSG8

Clone Products

  • Applied Biological Materials (abm): Clones for PSG8 - Now 50% OFF >
  • * PSG8 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * PSG8 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for PSG8 Gene

No ASD Table

Relevant External Links for PSG8 Gene

GeneLoc Exon Structure for
PSG8
ECgene alternative splicing isoforms for
PSG8

Expression for PSG8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSG8 Gene

mRNA differential expression in normal tissues according to GTEx for PSG8 Gene

This gene is overexpressed in Testis (x24.4).

Protein differential expression in normal tissues from HIPED for PSG8 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PSG8 Gene



Protein tissue co-expression partners for PSG8 Gene

NURSA nuclear receptor signaling pathways regulating expression of PSG8 Gene:

PSG8

SOURCE GeneReport for Unigene cluster for PSG8 Gene:

Hs.466843
genes like me logo Genes that share expression patterns with PSG8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSG8 Gene

Orthologs for PSG8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PSG8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSG8 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CEACAM1 35
  • 34 (a)
ManyToMany
-- 35
  • 26 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Ceacam14 35
  • 29 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 10 (a)
ManyToMany
Species where no ortholog for PSG8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PSG8 Gene

ENSEMBL:
Gene Tree for PSG8 (if available)
TreeFam:
Gene Tree for PSG8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PSG8: view image

Paralogs for PSG8 Gene

(23) SIMAP similar genes for PSG8 Gene using alignment to 3 proteins:

  • PSG8_HUMAN
  • E7ENH0_HUMAN
  • M0QYP3_HUMAN
genes like me logo Genes that share paralogs with PSG8: view

Variants for PSG8 Gene

Sequence variations from dbSNP and Humsavar for PSG8 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000140296 -- 42,752,778(-) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000292977 -- 42,767,554(-) G/A upstream_transcript_variant
rs1000352528 -- 42,754,096(-) A/G downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000744304 -- 42,753,500(-) T/A genic_downstream_transcript_variant, intron_variant
rs1001154369 -- 42,759,708(-) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PSG8 Gene

Variant ID Type Subtype PubMed ID
dgv140e55 CNV gain 17911159
dgv141e55 CNV loss 17911159
dgv15e196 CNV deletion 17116639
dgv3551n100 CNV gain 25217958
dgv3552n100 CNV gain 25217958
dgv3553n100 CNV gain 25217958
dgv3554n100 CNV gain 25217958
dgv3555n100 CNV gain 25217958
dgv3556n100 CNV gain 25217958
dgv3557n100 CNV gain 25217958
dgv3558n100 CNV loss 25217958
dgv523e201 CNV deletion 23290073
dgv6461n54 CNV gain 21841781
dgv6462n54 CNV gain 21841781
dgv6463n54 CNV gain 21841781
dgv73e203 CNV gain+loss 21179565
esv2422471 CNV deletion 17116639
esv2758763 CNV gain+loss 17122850
esv33217 CNV loss 17666407
esv3644406 CNV loss 21293372
esv3644407 CNV gain 21293372
nsv1056270 CNV loss 25217958
nsv1060654 CNV gain 25217958
nsv1065245 CNV gain+loss 25217958
nsv1136286 CNV deletion 24896259
nsv428364 CNV gain+loss 18775914
nsv471408 CNV gain 19718026
nsv482038 CNV gain 20164927
nsv510768 CNV deletion 20534489
nsv516973 CNV gain+loss 19592680
nsv828554 CNV gain 20364138
nsv833835 CNV gain 17160897
nsv953585 CNV deletion 24416366
nsv963056 CNV duplication 23825009
nsv9730 CNV gain+loss 18304495

Variation tolerance for PSG8 Gene

Residual Variation Intolerance Score: 99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.84; 73.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PSG8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSG8

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSG8 Gene

Disorders for PSG8 Gene

Additional Disease Information for PSG8

No disorders were found for PSG8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSG8 Gene

Publications for PSG8 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The pregnancy-specific glycoprotein family of the immunoglobulin superfamily: identification of new members and estimation of family size. (PMID: 1572651) Khan WN … Hammarström S (Genomics 1992) 2 3 58
  3. DNA polymorphisms and linkage relationship of the human complement component C6, C7, and C9 genes. (PMID: 1672663) Coto E … López-Larrea C (Immunogenetics 1991) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58

Products for PSG8 Gene

Sources for PSG8 Gene

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