This gene is a member of the pregnancy-specific glycoprotein (PSG) gene family. The PSG genes are a subgroup of the carcinoembryonic antigen (CEA) family of immunoglobulin-like genes, and are found in a gene cluster at 19q13.1-q13.2 telomeric to another cluster of CEA-related genes. The PSG genes are expressed by placental trophoblasts and released into the maternal circulation... See more...

Aliases for PSG6 Gene

Aliases for PSG6 Gene

  • Pregnancy Specific Beta-1-Glycoprotein 6 2 3 5
  • Pregnancy-Specific Beta-1-Glycoprotein 10 3 4
  • Pregnancy-Specific Beta-1-Glycoprotein 12 3 4
  • Pregnancy-Specific Beta-1-Glycoprotein 6 3 4
  • PS-Beta-G-10 3 4
  • PS-Beta-G-12 3 4
  • PS-Beta-G-6 3 4
  • PSBG-10 3 4
  • PSBG-12 3 4
  • PSBG-6 3 4
  • PSG10 3 4
  • PSGGB 3 4
  • Pregnancy-Specific Glycoprotein 10 4
  • Pregnancy-Specific Glycoprotein 12 4
  • Pregnancy-Specific Glycoprotein 6 4
  • PSG12 4
  • PSG6 5
  • CGM3 4

External Ids for PSG6 Gene

Previous GeneCards Identifiers for PSG6 Gene

  • GC19M044053
  • GC19M043764
  • GC19M048082
  • GC19M048101
  • GC19M048102
  • GC19M048106
  • GC19M043406
  • GC19M039837
  • GC19M042733

Summaries for PSG6 Gene

Entrez Gene Summary for PSG6 Gene

  • This gene is a member of the pregnancy-specific glycoprotein (PSG) gene family. The PSG genes are a subgroup of the carcinoembryonic antigen (CEA) family of immunoglobulin-like genes, and are found in a gene cluster at 19q13.1-q13.2 telomeric to another cluster of CEA-related genes. The PSG genes are expressed by placental trophoblasts and released into the maternal circulation during pregnancy, and are thought to be essential for maintenance of normal pregnancy. The protein encoded by this gene contains the Arg-Gly-Asp tripeptide associated with cellular adhesion and recognition. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for PSG6 Gene

PSG6 (Pregnancy Specific Beta-1-Glycoprotein 6) is a Protein Coding gene. Diseases associated with PSG6 include Chorioangioma. Among its related pathways are Cell surface interactions at the vascular wall and Response to elevated platelet cytosolic Ca2+. An important paralog of this gene is PSG3.

Gene Wiki entry for PSG6 Gene

Additional gene information for PSG6 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSG6 Gene

Genomics for PSG6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PSG6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J042917 Promoter 0.3 EPDnew 600.7 +1.6 1649 0.1 PSG6 PSG1 lnc-PSG1-1 lnc-CD177-5
GH19J042930 Enhancer 0.8 Ensembl ENCODE 0.4 -13.6 -13623 4.9 ZNF629 ZNF692 CTCF CEBPB ZBTB48 ZBTB17 BHLHE40 HIC1 ZNF366 FEZF1 PSG4 PAFAH1B3 PHLDB3 PSG7 lnc-PSG7-4 lnc-PSG6-1 PSG6 lnc-PSG1-1 lnc-CD177-5
GH19J042888 Enhancer 0.9 Ensembl ENCODE 0.3 +30.5 30470 3.8 CREB1 ATF7 PRDM10 ZNF629 ZNF692 PRDM1 ZNF600 SCRT2 ZBTB44 ZNF639 ENSG00000231412 PSG1 PSG6 lnc-CD177-5 lnc-PSG1-1
GH19J042896 Enhancer 0.7 Ensembl ENCODE 0.4 +20.6 20558 4.2 SP1 ZBTB17 SIN3A KLF9 TCF7L2 ZNF24 FOS SREBF1 PSG4 ENSG00000231412 PSG1 PSG6 lnc-CD177-5 lnc-PSG1-1
GH19J042884 Enhancer 0.6 ENCODE 0.3 +34.3 34318 0.8 CTCF TRIM22 ZNF444 NFIC SIN3A RAD21 SMC3 NFIB ZNF654 NFIA PSG1 PSG6 lnc-CD177-5 lnc-PSG1-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSG6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PSG6

Top Transcription factor binding sites by QIAGEN in the PSG6 gene promoter:
  • c-Myb
  • NF-kappaB
  • NF-kappaB1
  • POU3F1
  • Sp1

Genomic Locations for PSG6 Gene

Genomic Locations for PSG6 Gene
17,478 bases
Minus strand
17,485 bases
Minus strand

Genomic View for PSG6 Gene

Genes around PSG6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSG6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSG6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSG6 Gene

Proteins for PSG6 Gene

  • Protein details for PSG6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pregnancy-specific beta-1-glycoprotein 6
    Protein Accession:
    Secondary Accessions:
    • O75244
    • Q15224
    • Q15235
    • Q549K1

    Protein attributes for PSG6 Gene

    435 amino acids
    Molecular mass:
    48814 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PSG6 Gene


neXtProt entry for PSG6 Gene

Post-translational modifications for PSG6 Gene

  • Glycosylation at Asn61, Asn103, Asn110, Asn198, Asn267, Asn302, and Asn386
  • Modification sites at PhosphoSitePlus

Other Protein References for PSG6 Gene

No data available for DME Specific Peptides for PSG6 Gene

Domains & Families for PSG6 Gene

Gene Families for PSG6 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for PSG6 Gene

  • Immunoglobulin C-2 type
  • Immunoglobulin V-set

Suggested Antigen Peptide Sequences for PSG6 Gene

GenScript: Design optimal peptide antigens:
  • Pregnancy-specific beta-1-glycoprotein 12 (PSG6_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the immunoglobulin superfamily. CEA family.
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with PSG6: view

Function for PSG6 Gene

Molecular function for PSG6 Gene

GENATLAS Biochemistry:
pregnancy specific beta-1-glycoprotein 6,expressed by placental syncytiotrophoblasts,unknown function,carcinoembryonic antigen (CEA family),immunoglobulin superfamily

Gene Ontology (GO) - Molecular Function for PSG6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with PSG6: view
genes like me logo Genes that share phenotypes with PSG6: view

Animal Model Products

CRISPR Products

miRNA for PSG6 Gene

miRTarBase miRNAs that target PSG6

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSG6

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSG6 Gene

Localization for PSG6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSG6 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSG6 gene
Compartment Confidence
extracellular 5
plasma membrane 1
cytoskeleton 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for PSG6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 2271648
genes like me logo Genes that share ontologies with PSG6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PSG6 Gene

Pathways & Interactions for PSG6 Gene

genes like me logo Genes that share pathways with PSG6: view

Pathways by source for PSG6 Gene

Interacting Proteins for PSG6 Gene

Gene Ontology (GO) - Biological Process for PSG6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007565 female pregnancy TAS,NAS 2271648
genes like me logo Genes that share ontologies with PSG6: view

No data available for SIGNOR curated interactions for PSG6 Gene

Drugs & Compounds for PSG6 Gene

No Compound Related Data Available

Transcripts for PSG6 Gene

mRNA/cDNA for PSG6 Gene

6 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PSG6

Alternative Splicing Database (ASD) splice patterns (SP) for PSG6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
SP1: - - - - -
SP3: -

Relevant External Links for PSG6 Gene

GeneLoc Exon Structure for

Expression for PSG6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PSG6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PSG6 Gene

This gene is overexpressed in Testis (x12.4).

Protein differential expression in normal tissues from HIPED for PSG6 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PSG6 Gene

Protein tissue co-expression partners for PSG6 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PSG6

SOURCE GeneReport for Unigene cluster for PSG6 Gene:


Evidence on tissue expression from TISSUES for PSG6 Gene

  • Liver(4.2)
  • Bone marrow(4)
genes like me logo Genes that share expression patterns with PSG6: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSG6 Gene

Orthologs for PSG6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PSG6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC100612876 30
  • 92.41 (n)
(Bos Taurus)
Mammalia CEACAM1 31
  • 33 (a)
-- 31
  • 26 (a)
(Monodelphis domestica)
Mammalia -- 31
  • 28 (a)
(Mus musculus)
Mammalia Psg21 31
  • 21 (a)
Species where no ortholog for PSG6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for PSG6 Gene

Gene Tree for PSG6 (if available)
Gene Tree for PSG6 (if available)

Paralogs for PSG6 Gene

(25) SIMAP similar genes for PSG6 Gene using alignment to 5 proteins:

  • M0R314_HUMAN
genes like me logo Genes that share paralogs with PSG6: view

Variants for PSG6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PSG6 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
769011 Benign: not provided 42,916,299(-) G/C MISSENSE_VARIANT
775416 Benign: not provided 42,916,297(-) G/A SYNONYMOUS_VARIANT
rs1058674 - p.Leu155Phe
rs1058679 - p.Met161Thr
rs1058680 - p.Arg165Leu

Additional dbSNP identifiers (rs#s) for PSG6 Gene

Structural Variations from Database of Genomic Variants (DGV) for PSG6 Gene

Variant ID Type Subtype PubMed ID
dgv140e55 CNV gain 17911159
dgv141e55 CNV loss 17911159
dgv142e55 CNV loss 17911159
dgv143n111 CNV deletion 26073780
dgv144n111 CNV deletion 26073780
dgv15e196 CNV deletion 17116639
dgv223e215 CNV deletion 23714750
dgv3552n100 CNV gain 25217958
dgv3556n100 CNV gain 25217958
dgv3557n100 CNV gain 25217958
dgv3558n100 CNV loss 25217958
dgv3563n100 CNV gain 25217958
dgv3565n100 CNV gain+loss 25217958
dgv3566n100 CNV gain 25217958
dgv3567n100 CNV gain+loss 25217958
dgv3568n100 CNV loss 25217958
dgv3569n100 CNV gain 25217958
dgv3570n100 CNV gain+loss 25217958
dgv3571n100 CNV loss 25217958
dgv3572n100 CNV gain+loss 25217958
dgv3573n100 CNV loss 25217958
dgv3574n100 CNV gain 25217958
dgv3575n100 CNV loss 25217958
dgv3576n100 CNV loss 25217958
dgv409n27 CNV loss 19166990
dgv410n27 CNV gain 19166990
dgv411n27 CNV loss 19166990
dgv412n27 CNV gain 19166990
dgv413n27 CNV loss 19166990
dgv414n27 CNV gain 19166990
dgv415n27 CNV gain 19166990
dgv416n27 CNV loss 19166990
dgv523e201 CNV deletion 23290073
dgv524e201 CNV deletion 23290073
dgv589n67 CNV loss 20364138
dgv6464n54 CNV loss 21841781
dgv6465n54 CNV loss 21841781
dgv6466n54 CNV gain 21841781
dgv6467n54 CNV loss 21841781
dgv6468n54 CNV loss 21841781
dgv6469n54 CNV gain 21841781
dgv6470n54 CNV gain 21841781
dgv6471n54 CNV loss 21841781
dgv6472n54 CNV loss 21841781
dgv6474n54 CNV loss 21841781
dgv6475n54 CNV loss 21841781
dgv6476n54 CNV gain 21841781
dgv6477n54 CNV loss 21841781
dgv6478n54 CNV gain+loss 21841781
dgv6479n54 CNV gain 21841781
dgv6480n54 CNV gain+loss 21841781
dgv6481n54 CNV loss 21841781
dgv6482n54 CNV loss 21841781
dgv6483n54 CNV loss 21841781
dgv73e203 CNV gain+loss 21179565
esv22277 CNV gain+loss 19812545
esv2421673 OTHER complex 20811451
esv2422471 CNV deletion 17116639
esv2663048 CNV deletion 23128226
esv2668472 CNV deletion 23128226
esv2668787 CNV deletion 23128226
esv2718595 CNV deletion 23290073
esv2718597 CNV deletion 23290073
esv2718600 CNV deletion 23290073
esv2758763 CNV gain+loss 17122850
esv33217 CNV loss 17666407
esv3556427 CNV deletion 23714750
esv3584738 CNV loss 24956385
esv3644409 CNV loss 21293372
esv3644410 CNV loss 21293372
esv3644411 CNV loss 21293372
esv3644419 CNV loss 21293372
esv3644420 CNV gain 21293372
esv3644422 CNV loss 21293372
esv3644423 CNV loss 21293372
esv3893210 CNV loss 25118596
esv3893211 CNV gain+loss 25118596
esv3893214 CNV gain+loss 25118596
esv3893216 CNV gain+loss 25118596
nsv1055587 CNV loss 25217958
nsv1056270 CNV loss 25217958
nsv1057657 CNV gain 25217958
nsv1060654 CNV gain 25217958
nsv1066044 CNV gain 25217958
nsv1066286 CNV gain+loss 25217958
nsv1142088 CNV deletion 24896259
nsv1160630 OTHER complex 26073780
nsv1160634 CNV duplication 26073780
nsv1160636 CNV duplication 26073780
nsv2497 CNV deletion 18451855
nsv428364 CNV gain+loss 18775914
nsv442766 CNV gain+loss 18776908
nsv458650 CNV loss 19166990
nsv470143 CNV gain 18288195
nsv470145 CNV loss 18288195
nsv471410 CNV gain 19718026
nsv482040 CNV gain 20164927
nsv516973 CNV gain+loss 19592680
nsv579653 CNV gain 21841781
nsv579687 CNV gain+loss 21841781
nsv579702 CNV loss 21841781
nsv579704 CNV gain 21841781
nsv579712 CNV gain+loss 21841781
nsv579732 CNV loss 21841781
nsv579735 CNV gain 21841781
nsv579736 CNV gain 21841781
nsv579738 CNV loss 21841781
nsv579740 CNV loss 21841781
nsv817842 CNV gain+loss 17921354
nsv817843 CNV gain 17921354
nsv828554 CNV gain 20364138
nsv833835 CNV gain 17160897
nsv953586 CNV deletion 24416366
nsv963056 CNV duplication 23825009
nsv9730 CNV gain+loss 18304495

Variation tolerance for PSG6 Gene

Residual Variation Intolerance Score: 99.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.85; 48.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PSG6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSG6 Gene

Disorders for PSG6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PSG6 Gene - From: DISEASES

Disorder Aliases PubMed IDs
  • placental hemangioma
- elite association - COSMIC cancer census association via MalaCards
Search PSG6 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with PSG6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSG6 Gene

Publications for PSG6 Gene

  1. The human pregnancy-specific glycoprotein genes are tightly linked on the long arm of chromosome 19 and are coordinately expressed. (PMID: 1690992) Thompson J … Zaninetta D (Biochemical and biophysical research communications 1990) 2 3 4
  2. Linkage of two human pregnancy-specific beta 1-glycoprotein genes: one is associated with hydatidiform mole. (PMID: 2377620) Leslie KK … Chou JY (Proceedings of the National Academy of Sciences of the United States of America 1990) 3 4 23
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Characterization of two new members of the pregnancy-specific beta 1-glycoprotein family from the myeloid cell line KG-1 and suggestion of two distinct classes of transcription unit. (PMID: 2271648) Barnett TR … Elting JJ (Biochemistry 1990) 3 4

Products for PSG6 Gene

  • Signalway ELISA kits for PSG6

Sources for PSG6 Gene