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Aliases for PSG3 Gene

Aliases for PSG3 Gene

  • Pregnancy Specific Beta-1-Glycoprotein 3 2 3 5
  • Pregnancy-Specific Glycoprotein 3 3 4
  • Carcinoembryonic Antigen SG5 3 4
  • PS-Beta-G-3 3 4
  • PSBG-3 3 4
  • Pregnancy-Specific Beta-1-Glycoprotein 3 3

External Ids for PSG3 Gene

Previous GeneCards Identifiers for PSG3 Gene

  • GC19M043874
  • GC19M043617
  • GC19M047901
  • GC19M047917
  • GC19M043225
  • GC19M039655

Summaries for PSG3 Gene

Entrez Gene Summary for PSG3 Gene

  • The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 [PubMed 7851896]). For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]

GeneCards Summary for PSG3 Gene

PSG3 (Pregnancy Specific Beta-1-Glycoprotein 3) is a Protein Coding gene. Among its related pathways are Cell surface interactions at the vascular wall and Response to elevated platelet cytosolic Ca2+. An important paralog of this gene is PSG8.

Gene Wiki entry for PSG3 Gene

Additional gene information for PSG3 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSG3 Gene

Genomics for PSG3 Gene

GeneHancer (GH) Regulatory Elements for PSG3 Gene

Promoters and enhancers for PSG3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J042740 Promoter 0.5 EPDnew 650.7 +0.1 68 0.1 PSG3 PIR38528
GH19J042735 Enhancer 0.8 Ensembl ENCODE 0.7 +3.7 3699 2.5 ZBTB10 ZNF362 ZBTB21 USF2 CEBPB MITF ZFP69B RAD51 ZNF366 PSG8 PSG3 PIR38528
GH19J042760 Enhancer 1.2 FANTOM5 Ensembl ENCODE 0.3 -21.3 -21298 3.4 ZBTB21 JUN FEZF1 ZEB1 HIC1 GATA3 GLIS2 ZNF366 ZBTB48 FOS PSG8 PSG5 CEACAM1 GC19M042749 PSG3
GH19J042765 Promoter 0.5 EPDnew 0.3 -25.1 -25129 0.1 PSG8 GC19M042749 PSG3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSG3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PSG3 gene promoter:
  • Ik-1
  • RORalpha2
  • POU3F1
  • p300
  • RelA
  • NF-kappaB1
  • NF-kappaB
  • c-Myb
  • AREB6
  • NCX

Genomic Locations for PSG3 Gene

Genomic Locations for PSG3 Gene
18,932 bases
Minus strand
18,932 bases
Minus strand

Genomic View for PSG3 Gene

Genes around PSG3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSG3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSG3 Gene

Proteins for PSG3 Gene

  • Protein details for PSG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pregnancy-specific beta-1-glycoprotein 3
    Protein Accession:
    Secondary Accessions:
    • Q08265
    • Q9BRW2
    • Q9UPL4
    • Q9UQ77

    Protein attributes for PSG3 Gene

    428 amino acids
    Molecular mass:
    47945 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PSG3 Gene

Post-translational modifications for PSG3 Gene

  • Glycosylation at Asn303, Asn268, posLast=111111, and Asn104
  • Modification sites at PhosphoSitePlus

Other Protein References for PSG3 Gene

No data available for DME Specific Peptides for PSG3 Gene

Domains & Families for PSG3 Gene

Gene Families for PSG3 Gene

Suggested Antigen Peptide Sequences for PSG3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the immunoglobulin superfamily. CEA family.
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with PSG3: view

Function for PSG3 Gene

Molecular function for PSG3 Gene

GENATLAS Biochemistry:
pregnancy specific beta-1-glycoprotein 3,expressed by placental syncytiotrophoblasts,unknown function,carcinoembryonic antigen (CEA family),immunoglobulin superfamily
genes like me logo Genes that share phenotypes with PSG3: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSG3 Gene

Localization for PSG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSG3 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSG3 gene
Compartment Confidence
extracellular 4
mitochondrion 2
plasma membrane 1
cytosol 1

Gene Ontology (GO) - Cellular Components for PSG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PSG3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PSG3 Gene

Pathways & Interactions for PSG3 Gene

genes like me logo Genes that share pathways with PSG3: view

Pathways by source for PSG3 Gene

Gene Ontology (GO) - Biological Process for PSG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006952 defense response TAS 2341148
GO:0007565 female pregnancy TAS 2341148
genes like me logo Genes that share ontologies with PSG3: view

No data available for SIGNOR curated interactions for PSG3 Gene

Drugs & Compounds for PSG3 Gene

No Compound Related Data Available

Transcripts for PSG3 Gene

mRNA/cDNA for PSG3 Gene

Unigene Clusters for PSG3 Gene

Pregnancy specific beta-1-glycoprotein 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSG3 Gene

No ASD Table

Relevant External Links for PSG3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PSG3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSG3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PSG3 Gene

This gene is overexpressed in Testis (x31.4).

Protein differential expression in normal tissues from HIPED for PSG3 Gene

This gene is overexpressed in Lung (42.8) and Placenta (26.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PSG3 Gene

Protein tissue co-expression partners for PSG3 Gene

NURSA nuclear receptor signaling pathways regulating expression of PSG3 Gene:


SOURCE GeneReport for Unigene cluster for PSG3 Gene:


Evidence on tissue expression from TISSUES for PSG3 Gene

  • Intestine(4.1)
genes like me logo Genes that share expression patterns with PSG3: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSG3 Gene

Orthologs for PSG3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PSG3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PSG3 34 33
  • 98.47 (n)
(Bos Taurus)
Mammalia CEACAM1 34
  • 34 (a)
-- 34
  • 26 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 28 (a)
(Mus musculus)
Mammalia Psg27 34
  • 19 (a)
Species where no ortholog for PSG3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PSG3 Gene

Gene Tree for PSG3 (if available)
Gene Tree for PSG3 (if available)
Evolutionary constrained regions (ECRs) for PSG3: view image

Paralogs for PSG3 Gene

(24) SIMAP similar genes for PSG3 Gene using alignment to 3 proteins:

  • M0QX68_HUMAN
genes like me logo Genes that share paralogs with PSG3: view

Variants for PSG3 Gene

Sequence variations from dbSNP and Humsavar for PSG3 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000146576 -- 42,724,366(-) T/A intron_variant
rs1000197508 -- 42,729,654(-) C/T intron_variant
rs1000239652 -- 42,731,196(-) T/C intron_variant
rs1000274689 -- 42,741,825(-) C/G upstream_transcript_variant
rs1000360599 -- 42,734,135(-) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PSG3 Gene

Variant ID Type Subtype PubMed ID
dgv140e55 CNV gain 17911159
dgv141e55 CNV loss 17911159
dgv15e196 CNV deletion 17116639
dgv3551n100 CNV gain 25217958
dgv3552n100 CNV gain 25217958
dgv523e201 CNV deletion 23290073
dgv73e203 CNV gain+loss 21179565
esv2422471 CNV deletion 17116639
esv2758763 CNV gain+loss 17122850
esv3644405 CNV gain 21293372
esv3644406 CNV loss 21293372
esv3644407 CNV gain 21293372
nsv1056270 CNV loss 25217958
nsv1058936 CNV gain 25217958
nsv1060654 CNV gain 25217958
nsv428364 CNV gain+loss 18775914
nsv482222 CNV gain 20164927
nsv510768 CNV deletion 20534489
nsv516973 CNV gain+loss 19592680
nsv833835 CNV gain 17160897
nsv963056 CNV duplication 23825009
nsv9730 CNV gain+loss 18304495

Variation tolerance for PSG3 Gene

Residual Variation Intolerance Score: 98.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.09; 60.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PSG3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSG3 Gene

Disorders for PSG3 Gene

Additional Disease Information for PSG3

No disorders were found for PSG3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSG3 Gene

Publications for PSG3 Gene

  1. Structure, evolution and chromosomal localization of the human pregnancy-specific beta 1 glycoprotein gene family. (PMID: 2341148) Streydio C … Vassart G (Genomics 1990) 2 3 4 58
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Pregnancy specific beta 1-glycoprotein in human intestine. (PMID: 8487756) Shupert WL … Chan WY (Molecular and cellular biochemistry 1993) 3 4 58
  5. Expression of the pregnancy-specific beta 1-glycoprotein genes in human testis. (PMID: 2302228) Borjigin J … Chan WY (Biochemical and biophysical research communications 1990) 3 4 58

Products for PSG3 Gene

Sources for PSG3 Gene

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