The human pregnancy-specific glycoproteins (PSGs) are a group of molecules that are mainly produced by the placental syncytiotrophoblasts during pregnancy. PSGs comprise a subgroup of the carcinoembryonic antigen (CEA) family, which belongs to the immunoglobulin superfamily. For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, O... See more...

Aliases for PSG11 Gene

Aliases for PSG11 Gene

  • Pregnancy Specific Beta-1-Glycoprotein 11 2 3 5
  • Pregnancy-Specific Beta-1-Glycoprotein 11 3 4
  • Pregnancy-Specific Beta-1-Glycoprotein 13 3 4
  • PS-Beta-G-11 3 4
  • PS-Beta-G-13 3 4
  • PSBG-11 3 4
  • PSBG-13 3 4
  • PSG13 3 4
  • PSG14 3 4
  • Pregnancy Specific Beta-1-Glycoprotein 13 2
  • Pregnancy-Specific Glycoprotein 11 4
  • Pregnancy-Specific Glycoprotein 13 4

External Ids for PSG11 Gene

Previous HGNC Symbols for PSG11 Gene

  • PSG13
  • PSG14

Previous GeneCards Identifiers for PSG11 Gene

  • GC19M044160
  • GC19M043904
  • GC19M048057
  • GC19M048203
  • GC19M048205
  • GC19M047925
  • GC19M043407
  • GC19M039836
  • GC19M043511

Summaries for PSG11 Gene

Entrez Gene Summary for PSG11 Gene

  • The human pregnancy-specific glycoproteins (PSGs) are a group of molecules that are mainly produced by the placental syncytiotrophoblasts during pregnancy. PSGs comprise a subgroup of the carcinoembryonic antigen (CEA) family, which belongs to the immunoglobulin superfamily. For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]

GeneCards Summary for PSG11 Gene

PSG11 (Pregnancy Specific Beta-1-Glycoprotein 11) is a Protein Coding gene. Among its related pathways are Cell surface interactions at the vascular wall and Response to elevated platelet cytosolic Ca2+. An important paralog of this gene is PSG2.

Additional gene information for PSG11 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSG11 Gene

Genomics for PSG11 Gene

GeneHancer (GH) Regulatory Elements for PSG11 Gene

Promoters and enhancers for PSG11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J043026 Promoter 0.3 EPDnew 500.7 0.0 -12 0.1 PSG11 piR-38005-025 lnc-PSG1-1 ENSG00000282943 lnc-CD177-5
GH19J043025 Enhancer 0.3 Ensembl 500.7 +0.6 578 0.2 ZNF362 PSG11 PSG4 lnc-PSG2-4 lnc-PSG1-1 ENSG00000282943 lnc-CD177-5
GH19J043020 Enhancer 1.1 FANTOM5 Ensembl ENCODE 0.7 +4.0 3950 3.7 FOS ZEB1 BCL11A CEBPB JUN KLF8 SIN3A JUND ZNF335 MAX PSG4 ENSG00000231412 PSG11 lnc-PSG2-4 lnc-PSG1-1 ENSG00000282943 lnc-CD177-5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSG11 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PSG11

Top Transcription factor binding sites by QIAGEN in the PSG11 gene promoter:
  • AREB6
  • COUP
  • COUP-TF
  • COUP-TF1
  • HNF-4alpha1
  • HNF-4alpha2
  • NF-kappaB
  • NF-kappaB1
  • POU3F1
  • RelA

Genomic Locations for PSG11 Gene

Genomic Locations for PSG11 Gene
chr19:43,007,656-43,026,479
(GRCh38/hg38)
Size:
18,824 bases
Orientation:
Minus strand
chr19:43,511,808-43,530,664
(GRCh37/hg19)
Size:
18,857 bases
Orientation:
Minus strand

Genomic View for PSG11 Gene

Genes around PSG11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSG11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSG11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSG11 Gene

Proteins for PSG11 Gene

  • Protein details for PSG11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UQ72-PSG11_HUMAN
    Recommended name:
    Pregnancy-specific beta-1-glycoprotein 11
    Protein Accession:
    Q9UQ72
    Secondary Accessions:
    • Q13179
    • Q15242
    • Q8WW91
    • Q9UNE4

    Protein attributes for PSG11 Gene

    Size:
    335 amino acids
    Molecular mass:
    37146 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA36516.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAA75299.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAH20711.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for PSG11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSG11 Gene

Post-translational modifications for PSG11 Gene

  • Glycosylation at Asn61, Asn104, and Asn111
  • Modification sites at PhosphoSitePlus

Other Protein References for PSG11 Gene

No data available for DME Specific Peptides for PSG11 Gene

Domains & Families for PSG11 Gene

Gene Families for PSG11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for PSG11 Gene

Blocks:
  • Immunoglobulin C-2 type
  • Immunoglobulin subtype
  • Immunoglobulin V-set
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PSG11 Gene

GenScript: Design optimal peptide antigens:
  • Pregnancy-specific beta-1-glycoprotein 13 (PSG11_HUMAN)
  • Pregnancy-specific beta-1-glycoprotein (Q12810_HUMAN)
  • Pregnancy-specific beta-1-glycoprotein 11 C-R domain (Q12812_HUMAN)
  • Pregnancy-specific beta-1 glycoprotein-11 (Q15461_HUMAN)
  • Pregnancy-specific glycoprotein (Q9UMH8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UQ72

UniProtKB/Swiss-Prot:

PSG11_HUMAN :
  • Belongs to the immunoglobulin superfamily. CEA family.
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with PSG11: view

Function for PSG11 Gene

Molecular function for PSG11 Gene

GENATLAS Biochemistry:
pregnancy specific beta-1-glycoprotein 11,expressed by placental syncytiotrophoblasts,unknown function (CEA family) immunoglobulin superfamily

Phenotypes From GWAS Catalog for PSG11 Gene

genes like me logo Genes that share phenotypes with PSG11: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSG11 Gene

Localization for PSG11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSG11 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSG11 gene
Compartment Confidence
extracellular 3
plasma membrane 2
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PSG11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PSG11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PSG11 Gene

Pathways & Interactions for PSG11 Gene

genes like me logo Genes that share pathways with PSG11: view

Pathways by source for PSG11 Gene

2 Reactome pathways for PSG11 Gene

Gene Ontology (GO) - Biological Process for PSG11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007565 female pregnancy TAS 1690992
genes like me logo Genes that share ontologies with PSG11: view

No data available for SIGNOR curated interactions for PSG11 Gene

Drugs & Compounds for PSG11 Gene

No Compound Related Data Available

Transcripts for PSG11 Gene

mRNA/cDNA for PSG11 Gene

3 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSG11 Gene

No ASD Table

Relevant External Links for PSG11 Gene

GeneLoc Exon Structure for
PSG11

Expression for PSG11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PSG11 Gene

Protein differential expression in normal tissues from HIPED for PSG11 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PSG11 Gene



Protein tissue co-expression partners for PSG11 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PSG11

SOURCE GeneReport for Unigene cluster for PSG11 Gene:

Hs.741150

Evidence on tissue expression from TISSUES for PSG11 Gene

  • Liver(4.3)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with PSG11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSG11 Gene

Orthologs for PSG11 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PSG11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSG11 31
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CEACAM1 31
  • 28 (a)
ManyToMany
-- 31
  • 19 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Ceacam11 31
  • 25 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 25 (a)
ManyToMany
Species where no ortholog for PSG11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PSG11 Gene

ENSEMBL:
Gene Tree for PSG11 (if available)
TreeFam:
Gene Tree for PSG11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PSG11: view image

Paralogs for PSG11 Gene

(29) SIMAP similar genes for PSG11 Gene using alignment to 8 proteins:

  • PSG11_HUMAN
  • M0R276_HUMAN
  • M0R2P9_HUMAN
  • Q12810_HUMAN
  • Q12812_HUMAN
  • Q15227_HUMAN
  • Q15461_HUMAN
  • Q9UMH8_HUMAN
genes like me logo Genes that share paralogs with PSG11: view

Variants for PSG11 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PSG11 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs10412348 - p.Glu310Lys
rs10414166 - p.Asn264Asp
rs1058085 - p.Ala176Thr
rs2471952 - p.Val83Ile

Additional dbSNP identifiers (rs#s) for PSG11 Gene

Structural Variations from Database of Genomic Variants (DGV) for PSG11 Gene

Variant ID Type Subtype PubMed ID
dgv140e55 CNV gain 17911159
dgv141e55 CNV loss 17911159
dgv142e55 CNV loss 17911159
dgv143n111 CNV deletion 26073780
dgv144n111 CNV deletion 26073780
dgv15e196 CNV deletion 17116639
dgv223e215 CNV deletion 23714750
dgv3556n100 CNV gain 25217958
dgv3557n100 CNV gain 25217958
dgv3558n100 CNV loss 25217958
dgv3563n100 CNV gain 25217958
dgv3565n100 CNV gain+loss 25217958
dgv3566n100 CNV gain 25217958
dgv3570n100 CNV gain+loss 25217958
dgv3571n100 CNV loss 25217958
dgv3572n100 CNV gain+loss 25217958
dgv3573n100 CNV loss 25217958
dgv3574n100 CNV gain 25217958
dgv3575n100 CNV loss 25217958
dgv3576n100 CNV loss 25217958
dgv3577n100 CNV gain 25217958
dgv3578n100 CNV gain 25217958
dgv3579n100 CNV loss 25217958
dgv3580n100 CNV loss 25217958
dgv3581n100 CNV loss 25217958
dgv3582n100 CNV gain 25217958
dgv3583n100 CNV loss 25217958
dgv409n27 CNV loss 19166990
dgv410n27 CNV gain 19166990
dgv411n27 CNV loss 19166990
dgv413n27 CNV loss 19166990
dgv414n27 CNV gain 19166990
dgv415n27 CNV gain 19166990
dgv416n27 CNV loss 19166990
dgv417n27 CNV loss 19166990
dgv418n27 CNV loss 19166990
dgv419n27 CNV gain 19166990
dgv420n27 CNV loss 19166990
dgv421n27 CNV gain 19166990
dgv523e201 CNV deletion 23290073
dgv524e201 CNV deletion 23290073
dgv589n67 CNV loss 20364138
dgv6465n54 CNV loss 21841781
dgv6466n54 CNV gain 21841781
dgv6467n54 CNV loss 21841781
dgv6470n54 CNV gain 21841781
dgv6471n54 CNV loss 21841781
dgv6474n54 CNV loss 21841781
dgv6476n54 CNV gain 21841781
dgv6478n54 CNV gain+loss 21841781
dgv6479n54 CNV gain 21841781
dgv6480n54 CNV gain+loss 21841781
dgv6483n54 CNV loss 21841781
dgv6484n54 CNV gain 21841781
dgv6485n54 CNV loss 21841781
dgv6486n54 CNV loss 21841781
dgv6487n54 CNV loss 21841781
dgv6488n54 CNV gain 21841781
dgv6489n54 CNV loss 21841781
dgv6490n54 CNV loss 21841781
dgv662e214 CNV loss 21293372
dgv73e203 CNV gain+loss 21179565
esv22277 CNV gain+loss 19812545
esv2421574 OTHER complex 20811451
esv2421673 OTHER complex 20811451
esv2422471 CNV deletion 17116639
esv2657641 CNV deletion 23128226
esv2663048 CNV deletion 23128226
esv2718595 CNV deletion 23290073
esv2718602 CNV deletion 23290073
esv2751794 CNV gain 17911159
esv2758763 CNV gain+loss 17122850
esv33217 CNV loss 17666407
esv3556430 CNV deletion 23714750
esv3584738 CNV loss 24956385
esv3644410 CNV loss 21293372
esv3644411 CNV loss 21293372
esv3644430 CNV loss 21293372
esv3644435 CNV loss 21293372
esv3644436 CNV gain 21293372
esv3893210 CNV loss 25118596
esv3893211 CNV gain+loss 25118596
esv3893216 CNV gain+loss 25118596
esv3893217 CNV gain 25118596
esv3893218 CNV gain+loss 25118596
nsv1055355 CNV gain 25217958
nsv1056270 CNV loss 25217958
nsv1057657 CNV gain 25217958
nsv1058422 CNV loss 25217958
nsv1064459 CNV loss 25217958
nsv1064717 CNV gain+loss 25217958
nsv1065754 CNV loss 25217958
nsv1066305 CNV gain 25217958
nsv1142088 CNV deletion 24896259
nsv1160630 OTHER complex 26073780
nsv1160634 CNV duplication 26073780
nsv1160637 CNV duplication 26073780
nsv2497 CNV deletion 18451855
nsv437832 CNV loss 16327808
nsv458650 CNV loss 19166990
nsv458653 CNV loss 19166990
nsv469727 CNV loss 16826518
nsv470143 CNV gain 18288195
nsv470145 CNV loss 18288195
nsv471412 CNV gain 19718026
nsv482042 CNV gain 20164927
nsv516973 CNV gain+loss 19592680
nsv579653 CNV gain 21841781
nsv579687 CNV gain+loss 21841781
nsv579702 CNV loss 21841781
nsv579736 CNV gain 21841781
nsv579740 CNV loss 21841781
nsv579751 CNV gain 21841781
nsv579753 CNV gain 21841781
nsv579759 CNV loss 21841781
nsv817842 CNV gain+loss 17921354
nsv817843 CNV gain 17921354
nsv817844 CNV loss 17921354
nsv828554 CNV gain 20364138
nsv833837 CNV gain 17160897
nsv953586 CNV deletion 24416366
nsv963056 CNV duplication 23825009
nsv9730 CNV gain+loss 18304495

Variation tolerance for PSG11 Gene

Residual Variation Intolerance Score: 93.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PSG11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSG11

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSG11 Gene

Disorders for PSG11 Gene

Additional Disease Information for PSG11

No disorders were found for PSG11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSG11 Gene

Publications for PSG11 Gene

  1. Characterization of cDNA encoding novel pregnancy-specific glycoprotein variants. (PMID: 7794280) Teglund S … Hammarström S (Biochemical and biophysical research communications 1995) 2 3 4 23 54
  2. Cloning and expression of a new pregnancy-specific beta 1-glycoprotein member. (PMID: 1840485) Plouzek CA … Chou JY (Biochemical and biophysical research communications 1991) 3 4 54
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 54
  5. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 54

Products for PSG11 Gene

  • Signalway ELISA kits for PSG11
  • Signalway Proteins for PSG11

Sources for PSG11 Gene