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Aliases for PSG1 Gene

Aliases for PSG1 Gene

  • Pregnancy Specific Beta-1-Glycoprotein 1 2 3 5
  • Fetal Liver Non-Specific Cross-Reactive Antigen 1/2 3 4
  • Pregnancy-Specific Beta-1 Glycoprotein C/D 3 4
  • Pregnancy-Specific Beta-1-Glycoprotein 1 3 4
  • CD66 Antigen-Like Family Member F 3 4
  • PS-Beta-C/D 3 4
  • PS-Beta-G-1 3 4
  • FL-NCA-1/2 3 4
  • PSBG-1 3 4
  • PSBG1 3 4
  • PSG95 3 4
  • PSGGA 3 4
  • B1G1 3 4
  • Pregnancy-Specific B-1 Glycoprotein 3
  • Pregnancy-Specific Glycoprotein 1 4
  • CD66f Antigen 4
  • DHFRP2 3
  • PSGIIA 3
  • CD66f 3
  • PBG1 3
  • SP1 3

External Ids for PSG1 Gene

Previous HGNC Symbols for PSG1 Gene

  • PSBG1

Previous GeneCards Identifiers for PSG1 Gene

  • GC19M044018
  • GC19M043762
  • GC19M048024
  • GC19M048062
  • GC19M048063
  • GC19M047923
  • GC19M043348
  • GC19M039800

Summaries for PSG1 Gene

Entrez Gene Summary for PSG1 Gene

  • The human placenta is a multihormonal endocrine organ that produces hormones, enzymes, and other molecules that support fetal survival and development. Pregnancy-specific beta-1-glycoprotein (PSBG, PSG) is a major product of the syncytiotrophoblast, reaching concentrations of 100 to 290 mg/l at term in the serum of pregnant women (Horne et al., 1976 [PubMed 971765]). PSG is a member of the immunoglobulin (Ig) superfamily (Watanabe and Chou, 1988 [PubMed 3257488]; Streydio et al., 1988 [PubMed 3260773]).[supplied by OMIM, Oct 2009]

GeneCards Summary for PSG1 Gene

PSG1 (Pregnancy Specific Beta-1-Glycoprotein 1) is a Protein Coding gene. Among its related pathways are Cell surface interactions at the vascular wall and Response to elevated platelet cytosolic Ca2+. An important paralog of this gene is PSG8.

Gene Wiki entry for PSG1 Gene

Additional gene information for PSG1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSG1 Gene

Genomics for PSG1 Gene

GeneHancer (GH) Regulatory Elements for PSG1 Gene

Promoters and enhancers for PSG1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J042879 Promoter 0.5 EPDnew 600.7 +0.1 122 0.1 PSG1 GC19P042872
GH19J042878 Enhancer 0.2 Ensembl 600.7 +1.2 1221 0.4 PSG1 ENSG00000231412 LYPD3 GC19P042872
GH19J042874 Enhancer 0.8 FANTOM5 ENCODE 0.7 +3.8 3769 3.8 ATF7 CEBPB JUN SP1 JUND FOSL2 ATF2 FOS USF2 PSG4 ENSG00000231412 MEGF8 PSG5 GC19P042872 PSG1
GH19J042888 Enhancer 1 Ensembl ENCODE 0.4 -9.3 -9271 3.8 ZSCAN21 MAFK SP7 PRDM1 CREB1 GLIS2 ZNF600 PRDM10 ZEB2 ZNF639 ENSG00000231412 PSG1 GC19P042872 PSG6
GH19J042896 Enhancer 0.7 Ensembl ENCODE 0.4 -19.2 -19183 4.2 SP1 ZBTB17 TCF7L2 SIN3A FOS SREBF1 PSG4 ENSG00000231412 PSG1 PSG6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSG1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PSG1 gene promoter:
  • AREB6
  • c-Myb
  • GATA-1
  • Pax-2
  • Pax-2a

Genomic Locations for PSG1 Gene

Genomic Locations for PSG1 Gene
13,362 bases
Minus strand
13,362 bases
Minus strand

Genomic View for PSG1 Gene

Genes around PSG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSG1 Gene

Proteins for PSG1 Gene

  • Protein details for PSG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pregnancy-specific beta-1-glycoprotein 1
    Protein Accession:
    Secondary Accessions:
    • O75236
    • P11462
    • P11463
    • Q15231
    • Q15241
    • Q15243
    • Q16660
    • Q6ICR4
    • Q9P1W5
    • Q9UQ79

    Protein attributes for PSG1 Gene

    419 amino acids
    Molecular mass:
    47223 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PSG1 Gene


neXtProt entry for PSG1 Gene

Post-translational modifications for PSG1 Gene

  • Glycosylation at posLast=303303, posLast=111111, isoforms=2, 3, 4268, isoforms=2, 3, 4259, posLast=6161, posLast=104104, and isoforms=2, 3, 4199
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PSG1 Gene

Domains & Families for PSG1 Gene

Gene Families for PSG1 Gene

Human Protein Atlas (HPA):
  • CD markers
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for PSG1 Gene

GenScript: Design optimal peptide antigens:
  • Pregnancy specific beta-1-glycoprotein 1, isoform CRA_g (O75237_HUMAN)
  • Pregnancy specific beta-1-glycoprotein 1, isoform CRA_h (O75238_HUMAN)
  • Pregnancy-specific beta-1 glycoprotein C/D (PSG1_HUMAN)
  • Pregnancy-specific beta-1 glycoprotein (Q15106_HUMAN)
  • Pregnancy-specific beta-1 glycoprotein (Q15107_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the immunoglobulin superfamily. CEA family.
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with PSG1: view

Function for PSG1 Gene

Molecular function for PSG1 Gene

GENATLAS Biochemistry:
pregnancy specific beta-1-glycoprotein 1,expressed by placental syncytiotrophoblasts,unknown function,carcinoembryonic antigen (CEA family),immunoglobulin superfamily

Phenotypes From GWAS Catalog for PSG1 Gene

Gene Ontology (GO) - Molecular Function for PSG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with PSG1: view
genes like me logo Genes that share phenotypes with PSG1: view

Animal Model Products

CRISPR Products

Transcription Factor Targets for PSG1 Gene

Selected GeneGlobe predicted Target genes for PSG1

Clone Products

  • Applied Biological Materials (abm): Clones for PSG1 - Now 50% OFF >
  • * PSG1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * PSG1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA and HOMER Transcription for PSG1 Gene

Localization for PSG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSG1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSG1 gene
Compartment Confidence
extracellular 4

Gene Ontology (GO) - Cellular Components for PSG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with PSG1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PSG1 Gene

Pathways & Interactions for PSG1 Gene

genes like me logo Genes that share pathways with PSG1: view

Pathways by source for PSG1 Gene

Gene Ontology (GO) - Biological Process for PSG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007565 female pregnancy TAS 1572651
GO:0050900 leukocyte migration TAS --
genes like me logo Genes that share ontologies with PSG1: view

No data available for SIGNOR curated interactions for PSG1 Gene

Drugs & Compounds for PSG1 Gene

(3) Drugs for PSG1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for PSG1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PSG1: view

Transcripts for PSG1 Gene

Unigene Clusters for PSG1 Gene

Pregnancy specific beta-1-glycoprotein 1:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for PSG1 - Now 50% OFF >
  • * PSG1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * PSG1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for PSG1 Gene

No ASD Table

Relevant External Links for PSG1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PSG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSG1 Gene

mRNA differential expression in normal tissues according to GTEx for PSG1 Gene

This gene is overexpressed in Adipose - Subcutaneous (x5.1).

Protein differential expression in normal tissues from HIPED for PSG1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (56.7) and Placenta (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PSG1 Gene

Protein tissue co-expression partners for PSG1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PSG1 Gene:


SOURCE GeneReport for Unigene cluster for PSG1 Gene:


Evidence on tissue expression from TISSUES for PSG1 Gene

  • Nervous system(2.9)

Phenotype-based relationships between genes and organs from Gene ORGANizer for PSG1 Gene

Germ Layers:
  • mesoderm
  • immune
  • blood
  • white blood cell
genes like me logo Genes that share expression patterns with PSG1: view

No data available for mRNA Expression by UniProt/SwissProt for PSG1 Gene

Orthologs for PSG1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PSG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC100612418 34
  • 95.31 (n)
PSG1 35
  • 94 (a)
(Bos Taurus)
Mammalia CEACAM1 35
  • 34 (a)
-- 35
  • 26 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 26 (a)
(Mus musculus)
Mammalia Ceacam3 35
  • 15 (a)
Species where no ortholog for PSG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PSG1 Gene

Gene Tree for PSG1 (if available)
Gene Tree for PSG1 (if available)
Evolutionary constrained regions (ECRs) for PSG1: view image

Paralogs for PSG1 Gene

(25) SIMAP similar genes for PSG1 Gene using alignment to 14 proteins:

  • G5E9F7_HUMAN
  • M0QY44_HUMAN
  • M0R235_HUMAN
  • O75237_HUMAN
  • O75238_HUMAN
  • Q15106_HUMAN
  • Q15107_HUMAN
  • Q15108_HUMAN
  • Q15230_HUMAN
  • Q15402_HUMAN
  • Q9UPK9_HUMAN Pseudogenes for PSG1 Gene

genes like me logo Genes that share paralogs with PSG1: view

Variants for PSG1 Gene

Sequence variations from dbSNP and Humsavar for PSG1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000069283 -- 42,880,673(-) G/T upstream_transcript_variant
rs1000300208 -- 42,873,224(-) G/C intron_variant
rs1000354250 -- 42,867,366(-) G/C 3_prime_UTR_variant, intron_variant
rs1000394051 -- 42,867,495(-) C/A 3_prime_UTR_variant, intron_variant
rs1000744927 -- 42,869,513(-) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PSG1 Gene

Variant ID Type Subtype PubMed ID
dgv140e55 CNV gain 17911159
dgv141e55 CNV loss 17911159
dgv142e55 CNV loss 17911159
dgv143n111 CNV deletion 26073780
dgv144n111 CNV deletion 26073780
dgv15e196 CNV deletion 17116639
dgv223e215 CNV deletion 23714750
dgv3551n100 CNV gain 25217958
dgv3552n100 CNV gain 25217958
dgv3555n100 CNV gain 25217958
dgv3556n100 CNV gain 25217958
dgv3557n100 CNV gain 25217958
dgv3558n100 CNV loss 25217958
dgv3561n100 CNV gain+loss 25217958
dgv3562n100 CNV gain 25217958
dgv3563n100 CNV gain 25217958
dgv3564n100 CNV loss 25217958
dgv3565n100 CNV gain+loss 25217958
dgv3566n100 CNV gain 25217958
dgv3567n100 CNV gain+loss 25217958
dgv3568n100 CNV loss 25217958
dgv3569n100 CNV gain 25217958
dgv3570n100 CNV gain+loss 25217958
dgv3571n100 CNV loss 25217958
dgv3572n100 CNV gain+loss 25217958
dgv3573n100 CNV loss 25217958
dgv3574n100 CNV gain 25217958
dgv3575n100 CNV loss 25217958
dgv409n27 CNV loss 19166990
dgv410n27 CNV gain 19166990
dgv411n27 CNV loss 19166990
dgv412n27 CNV gain 19166990
dgv413n27 CNV loss 19166990
dgv414n27 CNV gain 19166990
dgv415n27 CNV gain 19166990
dgv416n27 CNV loss 19166990
dgv523e201 CNV deletion 23290073
dgv524e201 CNV deletion 23290073
dgv589n67 CNV loss 20364138
dgv6461n54 CNV gain 21841781
dgv6462n54 CNV gain 21841781
dgv6464n54 CNV loss 21841781
dgv6465n54 CNV loss 21841781
dgv6466n54 CNV gain 21841781
dgv6467n54 CNV loss 21841781
dgv6468n54 CNV loss 21841781
dgv6469n54 CNV gain 21841781
dgv6470n54 CNV gain 21841781
dgv6471n54 CNV loss 21841781
dgv6472n54 CNV loss 21841781
dgv6473n54 CNV loss 21841781
dgv6474n54 CNV loss 21841781
dgv6475n54 CNV loss 21841781
dgv6476n54 CNV gain 21841781
dgv6477n54 CNV loss 21841781
dgv6478n54 CNV gain+loss 21841781
dgv6479n54 CNV gain 21841781
dgv6480n54 CNV gain+loss 21841781
dgv73e203 CNV gain+loss 21179565
esv22277 CNV gain+loss 19812545
esv2421673 OTHER complex 20811451
esv2422471 CNV deletion 17116639
esv2663048 CNV deletion 23128226
esv2668472 CNV deletion 23128226
esv2718595 CNV deletion 23290073
esv2718597 CNV deletion 23290073
esv2718598 CNV deletion 23290073
esv2758763 CNV gain+loss 17122850
esv33217 CNV loss 17666407
esv3584738 CNV loss 24956385
esv3644409 CNV loss 21293372
esv3644410 CNV loss 21293372
esv3644411 CNV loss 21293372
esv3644417 CNV loss 21293372
esv3644419 CNV loss 21293372
esv3644420 CNV gain 21293372
esv3893210 CNV loss 25118596
esv3893211 CNV gain+loss 25118596
esv3893214 CNV gain+loss 25118596
esv3893216 CNV gain+loss 25118596
nsv1055587 CNV loss 25217958
nsv1056270 CNV loss 25217958
nsv1057657 CNV gain 25217958
nsv1060654 CNV gain 25217958
nsv1066044 CNV gain 25217958
nsv1066286 CNV gain+loss 25217958
nsv1142088 CNV deletion 24896259
nsv1160630 OTHER complex 26073780
nsv1160633 CNV duplication 26073780
nsv1160634 CNV duplication 26073780
nsv1160636 CNV duplication 26073780
nsv2497 CNV deletion 18451855
nsv428364 CNV gain+loss 18775914
nsv442766 CNV gain+loss 18776908
nsv470143 CNV gain 18288195
nsv470145 CNV loss 18288195
nsv471409 CNV gain 19718026
nsv482039 CNV gain 20164927
nsv516973 CNV gain+loss 19592680
nsv579653 CNV gain 21841781
nsv579687 CNV gain+loss 21841781
nsv579702 CNV loss 21841781
nsv579704 CNV gain 21841781
nsv579712 CNV gain+loss 21841781
nsv817841 CNV gain 17921354
nsv817842 CNV gain+loss 17921354
nsv817843 CNV gain 17921354
nsv828554 CNV gain 20364138
nsv833835 CNV gain 17160897
nsv953586 CNV deletion 24416366
nsv963056 CNV duplication 23825009
nsv9730 CNV gain+loss 18304495

Variation tolerance for PSG1 Gene

Residual Variation Intolerance Score: 99.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.28; 76.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PSG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSG1 Gene

Disorders for PSG1 Gene

Additional Disease Information for PSG1

No disorders were found for PSG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSG1 Gene

Publications for PSG1 Gene

  1. Linkage of two human pregnancy-specific beta 1-glycoprotein genes: one is associated with hydatidiform mole. (PMID: 2377620) Leslie KK … Chou JY (Proceedings of the National Academy of Sciences of the United States of America 1990) 3 4 23 58
  2. Pregnancy-specific {beta}-1-glycoprotein 1 and human leukocyte antigen-E mRNA in human sperm: differential expression in fertile and infertile men and evidence of a possible functional role during early development. (PMID: 18987160) Avendaño C … Oehninger S (Human reproduction (Oxford, England) 2009) 3 23 58
  3. First trimester maternal serum pregnancy-specific beta-1-glycoprotein (SP1) as a marker of adverse pregnancy outcome. (PMID: 19911417) Pihl K … Christiansen M (Prenatal diagnosis 2009) 3 23 58
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for PSG1 Gene

Sources for PSG1 Gene

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