Free for academic non-profit institutions. Other users need a Commercial license
PSD3 (Pleckstrin And Sec7 Domain Containing 3) is a Protein Coding gene. Diseases associated with PSD3 include Hepatocellular Carcinoma. Among its related pathways are Endocytosis. Gene Ontology (GO) annotations related to this gene include phospholipid binding and ARF guanyl-nucleotide exchange factor activity. An important paralog of this gene is PSD.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005085 | guanyl-nucleotide exchange factor activity | IBA | -- |
GO:0005086 | ARF guanyl-nucleotide exchange factor activity | IEA | -- |
GO:0005515 | protein binding | IEA | -- |
GO:0005543 | phospholipid binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | IEA | -- |
GO:0014069 | postsynaptic density | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0030054 | cell junction | IEA | -- |
GO:0032587 | ruffle membrane | IBA,ISS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Endocytosis |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0032012 | regulation of ARF protein signal transduction | IEA | -- |
GO:0050790 | regulation of catalytic activity | IEA | -- |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PSD3 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Psd3 30 17 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PSD3 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Rat (Rattus norvegicus) |
Mammalia | Psd3 30 |
|
||
Cow (Bos Taurus) |
Mammalia | PSD3 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Chicken (Gallus gallus) |
Aves | PSD3 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | PSD3 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | psd3 30 |
|
||
Str.16491 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | psd3l 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | Efa6 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | efa-6 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | GEA2 31 |
|
ManyToMany | |
GEA1 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 08 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs114838869 | Benign: not provided | 18,871,717(-) |
G/A NM_015310.4(PSD3):c.1147C>T (p.Arg383Cys) |
MISSENSE | |
rs139294568 | Benign: not provided | 18,872,192(-) |
G/C NM_015310.4(PSD3):c.672C>G (p.Asp224Glu) |
MISSENSE | |
rs143901818 | Benign: not provided | 18,801,368(-) |
G/T NM_015310.4(PSD3):c.1925C>A (p.Ala642Glu) |
MISSENSE | |
rs146066561 | Likely Benign: not provided | 18,871,840(-) |
G/A NM_015310.4(PSD3):c.1024C>T (p.Arg342Cys) |
MISSENSE | |
rs1586289298 | Uncertain Significance: Flexion contracture | 18,872,427(-) |
A/G NM_015310.4(PSD3):c.437T>C (p.Ile146Thr) |
MISSENSE |
Disorder | Aliases | PubMed IDs |
---|---|---|
hepatocellular carcinoma |
|
|