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Aliases for PSCA Gene

Aliases for PSCA Gene

  • Prostate Stem Cell Antigen 2 3 5
  • PRO232 3

External Ids for PSCA Gene

Previous GeneCards Identifiers for PSCA Gene

  • GC08U990071
  • GC08M143995
  • GC08P143556
  • GC08P143824
  • GC08P143758
  • GC08P139004

Summaries for PSCA Gene

Entrez Gene Summary for PSCA Gene

  • This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

GeneCards Summary for PSCA Gene

PSCA (Prostate Stem Cell Antigen) is a Protein Coding gene. Diseases associated with PSCA include Colloid Carcinoma Of The Pancreas and Prostate Cancer. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins.

UniProtKB/Swiss-Prot for PSCA Gene

  • May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro.

  • May act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs.

Gene Wiki entry for PSCA Gene

Additional gene information for PSCA Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSCA Gene

Genomics for PSCA Gene

GeneHancer (GH) Regulatory Elements for PSCA Gene

Promoters and enhancers for PSCA Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I142667 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 572.3 -0.4 -368 5.8 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZBTB7B ZNF766 E2F8 ZNF143 JRK PSCA LY6K ZNF623 SLURP1 ZC3H3 C8orf31 ENSG00000255050 PIR47130
GH08I142674 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 573.6 +9.4 9443 11 HDGF CLOCK ATF1 NEUROD1 SIN3A ZBTB7B TCF12 GLIS2 ZNF143 FOS PSCA LY6K THEM6 SLURP1 JRK
GH08I142698 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 12.6 +29.7 29725 3.2 ARNT FEZF1 ZNF2 GLIS2 ZNF213 FOS REST TSHZ1 ZNF488 ZNF518A LY6K PIR40452 THEM6 SLURP1 PSCA LYPD2
GH08I142725 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.9 +56.9 56921 3.2 PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 THEM6 ENSG00000253806 LOC100288181 LY6K JRK ZNF623 ZNF696 ENSG00000255050 ZC3H3 GLI4
GH08I142672 Enhancer 0.4 dbSUPER 21.8 +3.1 3137 1.2 ZNF680 ZSCAN29 PSCA THEM6 SLURP1 JRK
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PSCA on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PSCA gene promoter:

Genomic Locations for PSCA Gene

Genomic Locations for PSCA Gene
chr8:142,670,308-142,682,727
(GRCh38/hg38)
Size:
12,420 bases
Orientation:
Plus strand
chr8:143,751,726-143,764,145
(GRCh37/hg19)

Genomic View for PSCA Gene

Genes around PSCA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSCA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSCA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSCA Gene

Proteins for PSCA Gene

  • Protein details for PSCA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43653-PSCA_HUMAN
    Recommended name:
    Prostate stem cell antigen
    Protein Accession:
    O43653
    Secondary Accessions:
    • Q6UW92

    Protein attributes for PSCA Gene

    Size:
    123 amino acids
    Molecular mass:
    12912 Da
    Quaternary structure:
    • Interacts with CHRNA4.

neXtProt entry for PSCA Gene

Post-translational modifications for PSCA Gene

  • Glycosylation at isoforms=40, Asn83, and Asn93

Other Protein References for PSCA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for PSCA
  • Santa Cruz Biotechnology (SCBT) Antibodies for PSCA

No data available for DME Specific Peptides for PSCA Gene

Domains & Families for PSCA Gene

Gene Families for PSCA Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for PSCA Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PSCA Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PSCA: view

No data available for UniProtKB/Swiss-Prot for PSCA Gene

Function for PSCA Gene

Molecular function for PSCA Gene

GENATLAS Biochemistry:
prostate stem cell antigen,expressed at the cell surface of the basal cell epithelium,putative stem cell compartment of normal prostate,overexpressed in prostate carcinoma
UniProtKB/Swiss-Prot Function:
May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro.
UniProtKB/Swiss-Prot Function:
May act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs.
UniProtKB/Swiss-Prot Induction:
Down-regulated in gastric cancer cells.

Phenotypes From GWAS Catalog for PSCA Gene

Gene Ontology (GO) - Molecular Function for PSCA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033130 acetylcholine receptor binding IDA 25680266
genes like me logo Genes that share ontologies with PSCA: view
genes like me logo Genes that share phenotypes with PSCA: view

Animal Models for PSCA Gene

MGI Knock Outs for PSCA:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PSCA Gene

Localization for PSCA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSCA Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSCA gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PSCA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0031225 anchored component of membrane IEA --
GO:0070062 extracellular exosome HDA,IDA 23376485
genes like me logo Genes that share ontologies with PSCA: view

Pathways & Interactions for PSCA Gene

genes like me logo Genes that share pathways with PSCA: view

Interacting Proteins for PSCA Gene

Selected Interacting proteins: O43653-PSCA_HUMAN for PSCA Gene via IID

Gene Ontology (GO) - Biological Process for PSCA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006501 C-terminal protein lipidation TAS --
GO:0070373 negative regulation of ERK1 and ERK2 cascade IDA 25680266
GO:0099601 regulation of neurotransmitter receptor activity IDA 25680266
genes like me logo Genes that share ontologies with PSCA: view

No data available for SIGNOR curated interactions for PSCA Gene

Drugs & Compounds for PSCA Gene

(2) Drugs for PSCA Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
AGS-1C4D4 Pharma 0
AGS-PSCA Pharma 0
genes like me logo Genes that share compounds with PSCA: view

Transcripts for PSCA Gene

Unigene Clusters for PSCA Gene

Prostate stem cell antigen:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSCA Gene

No ASD Table

Relevant External Links for PSCA Gene

GeneLoc Exon Structure for
PSCA
ECgene alternative splicing isoforms for
PSCA

Expression for PSCA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSCA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PSCA Gene

This gene is overexpressed in Stomach (x32.5), Bladder (x11.4), and Esophagus - Mucosa (x4.2).

Protein differential expression in normal tissues from HIPED for PSCA Gene

This gene is overexpressed in Nasal epithelium (22.0), Urine (12.5), Stomach (9.5), Pancreatic juice (8.1), and Cardia (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PSCA Gene



NURSA nuclear receptor signaling pathways regulating expression of PSCA Gene:

PSCA

SOURCE GeneReport for Unigene cluster for PSCA Gene:

Hs.652235

mRNA Expression by UniProt/SwissProt for PSCA Gene:

O43653-PSCA_HUMAN
Tissue specificity: Highly expressed in prostate (basal, secretory and neuroendocrine epithelium cells). Also found in bladder (transitional epithelium), placenta (trophoblasts), stomach (neuroendocrine cells), colon (neuroendocrine cells) and kidney (collecting ducts). Overexpressed in prostate cancers and expression is correlated with tumor stage, grade and androgen-independence. Highly expressed in prostate cancer bone metastases. Expressed in gastric epithelial cells, mainly in the isthmus (at protein level). Not detected in normal intestinal epithelium (at protein level). Expressed in brain cortex; expression is significantly increased in the front cortex of Alzheimer disease patients.

Evidence on tissue expression from TISSUES for PSCA Gene

  • Skin(4.2)
  • Stomach(3.4)
genes like me logo Genes that share expression patterns with PSCA: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSCA Gene

Orthologs for PSCA Gene

This gene was present in the common ancestor of chordates.

Orthologs for PSCA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSCA 33 34
  • 99.12 (n)
dog
(Canis familiaris)
Mammalia PSCA 33 34
  • 79.01 (n)
cow
(Bos Taurus)
Mammalia PSCA 33 34
  • 77.14 (n)
mouse
(Mus musculus)
Mammalia Psca 33 16 34
  • 70.27 (n)
rat
(Rattus norvegicus)
Mammalia Psca 33
  • 66.37 (n)
chicken
(Gallus gallus)
Aves PSCA 33 34
  • 55.81 (n)
lizard
(Anolis carolinensis)
Reptilia PSCA 34
  • 37 (a)
OneToOne
Species where no ortholog for PSCA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PSCA Gene

ENSEMBL:
Gene Tree for PSCA (if available)
TreeFam:
Gene Tree for PSCA (if available)

Paralogs for PSCA Gene

(2) SIMAP similar genes for PSCA Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PSCA: view

No data available for Paralogs for PSCA Gene

Variants for PSCA Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for PSCA Gene

PSCA_HUMAN-O43653
Genetic variations in PSCA may influence susceptibility to diffuse-type gastric cancer.

Sequence variations from dbSNP and Humsavar for PSCA Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000432315 -- 142,669,360(+) C/T upstream_transcript_variant
rs1000484877 -- 142,669,533(+) G/A/C upstream_transcript_variant
rs1000816882 -- 142,668,456(+) T/C upstream_transcript_variant
rs1000893130 -- 142,674,397(+) C/A genic_upstream_transcript_variant, intron_variant
rs1001018207 -- 142,679,937(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PSCA Gene

Variant ID Type Subtype PubMed ID
nsv950003 CNV deletion 24416366
nsv831485 CNV loss 17160897
nsv612712 CNV loss 21841781
nsv612709 CNV loss 21841781
nsv428207 CNV gain+loss 18775914
nsv1146468 CNV deletion 26484159
nsv1119190 CNV deletion 24896259
nsv1109999 CNV deletion 24896259
esv3544370 CNV deletion 23714750
esv2737923 CNV deletion 23290073
esv2737922 CNV deletion 23290073
esv2737919 CNV deletion 23290073
esv2737916 CNV deletion 23290073
esv2737915 CNV deletion 23290073
esv2661137 CNV deletion 23128226
esv1920240 CNV deletion 18987734
dgv1235e201 CNV deletion 23290073

Variation tolerance for PSCA Gene

Residual Variation Intolerance Score: 63.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.36; 41.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PSCA Gene

Human Gene Mutation Database (HGMD)
PSCA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSCA

Disorders for PSCA Gene

MalaCards: The human disease database

(10) MalaCards diseases for PSCA Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
colloid carcinoma of the pancreas
prostate cancer
  • prostate cancer, susceptibility to
gastric cancer
  • gastric cancer, somatic
pancreatic cancer
  • pancreatic carcinoma
transitional cell carcinoma
  • transitional carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search PSCA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PSCA

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PSCA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSCA Gene

Publications for PSCA Gene

  1. Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer. (PMID: 18488030) Study Group of Millennium Genome Project for Cancer … Hirohashi S (Nature genetics 2008) 3 4 22 44 58
  2. Prostate stem cell antigen: a cell surface marker overexpressed in prostate cancer. (PMID: 9465086) Reiter RE … Witte ON (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 22 58
  3. Genetic variation in PSCA and bladder cancer susceptibility in a Chinese population. (PMID: 20083643) Wang S … Zhang Z (Carcinogenesis 2010) 3 22 44 58
  4. Two genetic variants in prostate stem cell antigen and gastric cancer susceptibility in a Chinese population. (PMID: 19554573) Wu C … Lin D (Molecular carcinogenesis 2009) 3 22 44 58
  5. Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer. (PMID: 19648920) Wu X … Gu J (Nature genetics 2009) 3 22 44 58

Products for PSCA Gene

Sources for PSCA Gene

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