Aliases for PRXL2C Gene

Aliases for PRXL2C Gene

  • Peroxiredoxin Like 2C 2 3 5
  • AhpC/TSA Antioxidant Enzyme Domain-Containing Protein 1 3 4
  • AhpC/TSA Antioxidant Enzyme Domain Containing 1 2 3
  • Thioredoxin-Like Protein AAED1 3 4
  • Peroxiredoxin-Like 2C 3 4
  • C9orf21 3 4
  • AAED1 3 4
  • Chromosome 9 Open Reading Frame 21 2
  • UPF0308 Protein C9orf21 3

External Ids for PRXL2C Gene

Previous HGNC Symbols for PRXL2C Gene

  • C9orf21
  • AAED1

Summaries for PRXL2C Gene

GeneCards Summary for PRXL2C Gene

PRXL2C (Peroxiredoxin Like 2C) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for PRXL2C Gene

  • May regulate positively ERK1/2 signaling and AKT1 activation leading to HIF1A up-regulation with an increased expression of glycolysis genes and enhanced glycolysis.

Additional gene information for PRXL2C Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRXL2C Gene

Genomics for PRXL2C Gene

GeneHancer (GH) Regulatory Elements for PRXL2C Gene

Promoters and enhancers for PRXL2C Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRXL2C on UCSC Golden Path with GeneCards custom track

Genomic Locations for PRXL2C Gene

Genomic Locations for PRXL2C Gene
chr9:96,639,577-96,655,323
(GRCh38/hg38)
Size:
15,747 bases
Orientation:
Minus strand
chr9:99,401,859-99,417,599
(GRCh37/hg19)
Size:
15,741 bases
Orientation:
Minus strand

Genomic View for PRXL2C Gene

Genes around PRXL2C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRXL2C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRXL2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRXL2C Gene

Proteins for PRXL2C Gene

  • Protein details for PRXL2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTV5-PXL2C_HUMAN
    Recommended name:
    Peroxiredoxin-like 2C
    Protein Accession:
    Q7RTV5
    Secondary Accessions:
    • B2RMW4
    • Q5JU02

    Protein attributes for PRXL2C Gene

    Size:
    226 amino acids
    Molecular mass:
    24857 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRXL2C Gene

Post-translational modifications for PRXL2C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRXL2C Gene

No data available for DME Specific Peptides for PRXL2C Gene

Domains & Families for PRXL2C Gene

Gene Families for PRXL2C Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PRXL2C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRXL2C Gene

GenScript: Design optimal peptide antigens:
  • C9orf21 protein (B7ZKK1_HUMAN)
  • UPF0308 protein C9orf21 (CI021_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7RTV5

UniProtKB/Swiss-Prot:

PXL2C_HUMAN :
  • Belongs to the peroxiredoxin-like PRXL2 family. PRXL2C subfamily.
Family:
  • Belongs to the peroxiredoxin-like PRXL2 family. PRXL2C subfamily.
genes like me logo Genes that share domains with PRXL2C: view

Function for PRXL2C Gene

Molecular function for PRXL2C Gene

UniProtKB/Swiss-Prot Function:
May regulate positively ERK1/2 signaling and AKT1 activation leading to HIF1A up-regulation with an increased expression of glycolysis genes and enhanced glycolysis.

Phenotypes From GWAS Catalog for PRXL2C Gene

Gene Ontology (GO) - Molecular Function for PRXL2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016209 antioxidant activity IBA 21873635
genes like me logo Genes that share ontologies with PRXL2C: view
genes like me logo Genes that share phenotypes with PRXL2C: view

Animal Model Products

CRISPR Products

miRNA for PRXL2C Gene

miRTarBase miRNAs that target PRXL2C

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRXL2C

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRXL2C Gene

Localization for PRXL2C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRXL2C gene
Compartment Confidence
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for PRXL2C Gene

Pathways & Interactions for PRXL2C Gene

PathCards logo

SuperPathways for PRXL2C Gene

No Data Available

Interacting Proteins for PRXL2C Gene

Gene Ontology (GO) - Biological Process for PRXL2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045821 positive regulation of glycolytic process IMP 29901208
GO:0055114 oxidation-reduction process IBA,IEA 21873635
GO:0070374 positive regulation of ERK1 and ERK2 cascade IMP 29901208
GO:0098869 cellular oxidant detoxification IEA --
genes like me logo Genes that share ontologies with PRXL2C: view

No data available for Pathways by source and SIGNOR curated interactions for PRXL2C Gene

Drugs & Compounds for PRXL2C Gene

No Compound Related Data Available

Transcripts for PRXL2C Gene

mRNA/cDNA for PRXL2C Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRXL2C

Alternative Splicing Database (ASD) splice patterns (SP) for PRXL2C Gene

No ASD Table

Relevant External Links for PRXL2C Gene

GeneLoc Exon Structure for
PRXL2C
ECgene alternative splicing isoforms for
PRXL2C

Expression for PRXL2C Gene

NURSA nuclear receptor signaling pathways regulating expression of PRXL2C Gene:

PRXL2C

SOURCE GeneReport for Unigene cluster for PRXL2C Gene:

Hs.44640

mRNA Expression by UniProt/SwissProt for PRXL2C Gene:

Q7RTV5-PXL2C_HUMAN
Tissue specificity: Expressed in gastric tissues.

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRXL2C Gene

Orthologs for PRXL2C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRXL2C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AAED1 33 32
  • 99.41 (n)
OneToOne
cow
(Bos Taurus)
Mammalia AAED1 33 32
  • 90.86 (n)
OneToOne
dog
(Canis familiaris)
Mammalia AAED1 33 32
  • 90.62 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Aaed1 33 32
  • 86.79 (n)
OneToOne
Prxl2c 17
chicken
(Gallus gallus)
Aves C9ORF21 32
  • 73.05 (n)
AAED1 33
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AAED1 33
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia aaed1 32
  • 61.65 (n)
Str.4655 32
zebrafish
(Danio rerio)
Actinopterygii LOC100332791 32
  • 58.86 (n)
AAED1 33
  • 54 (a)
OneToOne
Dr.16712 32
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.215 32
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G37240 32
  • 45.34 (n)
rice
(Oryza sativa)
Liliopsida Os03g0284600 32
  • 42.56 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10381 33
  • 32 (a)
OneToOne
Species where no ortholog for PRXL2C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRXL2C Gene

ENSEMBL:
Gene Tree for PRXL2C (if available)
TreeFam:
Gene Tree for PRXL2C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRXL2C: view image

Paralogs for PRXL2C Gene

Pseudogenes.org Pseudogenes for PRXL2C Gene

genes like me logo Genes that share paralogs with PRXL2C: view

No data available for Paralogs for PRXL2C Gene

Variants for PRXL2C Gene

Sequence variations from dbSNP and Humsavar for PRXL2C Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000010551 -- 96,649,834(-) C/G intron_variant
rs1000035773 -- 96,640,725(-) G/A/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000362731 -- 96,654,834(-) A/C intron_variant
rs1000691767 -- 96,643,505(-) C/G intron_variant
rs1000983037 -- 96,642,971(-) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PRXL2C Gene

Variant ID Type Subtype PubMed ID
nsv1147999 OTHER inversion 26484159
nsv824999 CNV gain 20364138

Variation tolerance for PRXL2C Gene

Residual Variation Intolerance Score: 90.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.06; 68.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRXL2C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRXL2C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRXL2C Gene

Disorders for PRXL2C Gene

Additional Disease Information for PRXL2C

No disorders were found for PRXL2C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRXL2C Gene

Publications for PRXL2C Gene

  1. AAED1 modulates proliferation and glycolysis in gastric cancer. (PMID: 29901208) Zhang B … Gu Y (Oncology reports 2018) 3 4 56
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 56
  3. Fugu and human sequence comparison identifies novel human genes and conserved non-coding sequences. (PMID: 12234665) Gilligan P … Venkatesh B (Gene 2002) 3 4 56
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 56

Products for PRXL2C Gene

Sources for PRXL2C Gene