Aliases for PRXL2B Gene

Aliases for PRXL2B Gene

  • Peroxiredoxin Like 2B 2 3 5
  • Prostamide/Prostaglandin F Synthase 2 3 4
  • Thioredoxin-Type PGF Synthase 2 3
  • Prostamide/PG F Synthase 3 4
  • Prostamide/PGF Synthase 3 4
  • C1orf93 3 4
  • FAM213B 3 4
  • Family With Sequence Similarity 213, Member B 2
  • Family With Sequence Similarity 213 Member B 3
  • Chromosome 1 Open Reading Frame 93 2
  • Peroxiredoxin-Like 2B 4
  • Protein FAM213B 4
  • EC 1.11.1.20 4
  • MGC26818 2
  • PRXL2B 5

External Ids for PRXL2B Gene

Previous HGNC Symbols for PRXL2B Gene

  • C1orf93
  • FAM213B

Summaries for PRXL2B Gene

GeneCards Summary for PRXL2B Gene

PRXL2B (Peroxiredoxin Like 2B) is a Protein Coding gene. Among its related pathways are Metabolism and Linoleic acid metabolism.

UniProtKB/Swiss-Prot Summary for PRXL2B Gene

  • Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha) (By similarity).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRXL2B Gene

Genomics for PRXL2B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PRXL2B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRXL2B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRXL2B

Genomic Locations for PRXL2B Gene

Latest Assembly
chr1:2,586,491-2,591,469
(GRCh38/hg38)
Size:
4,979 bases
Orientation:
Plus strand

Previous Assembly
chr1:2,517,962-2,522,907
(GRCh37/hg19 by Entrez Gene)
Size:
4,946 bases
Orientation:
Plus strand

chr1:2,517,930-2,522,908
(GRCh37/hg19 by Ensembl)
Size:
4,979 bases
Orientation:
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr1(ALT_REF_LOCI_1):137,713-142,658 (+)

Genomic View for PRXL2B Gene

Genes around PRXL2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRXL2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRXL2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRXL2B Gene

Proteins for PRXL2B Gene

  • Protein details for PRXL2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBF2-PXL2B_HUMAN
    Recommended name:
    Prostamide/prostaglandin F synthase
    Protein Accession:
    Q8TBF2
    Secondary Accessions:
    • A8K793
    • B3KPY3
    • B4DQR9
    • B4E0S5
    • B7ZAC8
    • B9DI90
    • B9DI92
    • J3KQD0
    • Q8N2H0

    Protein attributes for PRXL2B Gene

    Size:
    198 amino acids
    Molecular mass:
    21223 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PRXL2B Gene

neXtProt entry for PRXL2B Gene

Post-translational modifications for PRXL2B Gene

  • Ubiquitination at Lys101 and Lys120
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PRXL2B Gene

Domains & Families for PRXL2B Gene

Gene Families for PRXL2B Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PRXL2B Gene

Suggested Antigen Peptide Sequences for PRXL2B Gene

GenScript: Design optimal peptide antigens:
  • Prostamide/prostaglandin F synthase (PGFS_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TBF2

UniProtKB/Swiss-Prot:

PXL2B_HUMAN :
  • Belongs to the peroxiredoxin-like PRXL2 family. Prostamide/prostaglandin F synthase subfamily.
Family:
  • Belongs to the peroxiredoxin-like PRXL2 family. Prostamide/prostaglandin F synthase subfamily.
genes like me logo Genes that share domains with PRXL2B: view

Function for PRXL2B Gene

Molecular function for PRXL2B Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha) (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=[thioredoxin]-dithiol + prostaglandin H2 = [thioredoxin]-disulfide + prostaglandin F2alpha; Xref=Rhea:RHEA:28214, Rhea:RHEA-COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57404, ChEBI:CHEBI:57405; EC=1.11.1.20; Evidence={ECO:0000250|UniProtKB:Q9DB60};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=[thioredoxin]-disulfide + prostamide F2alpha = [thioredoxin]-dithiol + prostamide H2; Xref=Rhea:RHEA:26373, Rhea:RHEA-COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:53081, ChEBI:CHEBI:53082; EC=1.11.1.20; Evidence={ECO:0000250|UniProtKB:Q9DB60};.

Enzyme Numbers (IUBMB) for PRXL2B Gene

Phenotypes From GWAS Catalog for PRXL2B Gene

Gene Ontology (GO) - Molecular Function for PRXL2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32296183
GO:0016209 antioxidant activity IBA 21873635
GO:0016491 oxidoreductase activity IEA --
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA,ISS 18006499
GO:0047017 prostaglandin-F synthase activity IEA,ISS 18006499
genes like me logo Genes that share ontologies with PRXL2B: view
genes like me logo Genes that share phenotypes with PRXL2B: view

Animal Models for PRXL2B Gene

MGI Knock Outs for PRXL2B:
  • Prxl2b Prxl2b<tm1b(EUCOMM)Hmgu>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRXL2B

Clone products for research

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRXL2B Gene

Localization for PRXL2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRXL2B Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRXL2B gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 4
cytosol 3
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRXL2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,ISS 18006499
GO:0005783 endoplasmic reticulum IEA,ISS 18006499
GO:0005829 cytosol IEA --
GO:0043209 myelin sheath IEA,ISS 18006499
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with PRXL2B: view

Pathways & Interactions for PRXL2B Gene

genes like me logo Genes that share pathways with PRXL2B: view

Gene Ontology (GO) - Biological Process for PRXL2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001516 prostaglandin biosynthetic process IEA,ISS 18006499
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006633 fatty acid biosynthetic process IEA --
GO:0006693 prostaglandin metabolic process IEA --
genes like me logo Genes that share ontologies with PRXL2B: view

No data available for SIGNOR curated interactions for PRXL2B Gene

Drugs & Compounds for PRXL2B Gene

No Compound Related Data Available

Transcripts for PRXL2B Gene

mRNA/cDNA for PRXL2B Gene

6 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRXL2B

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for PRXL2B Gene

No ASD Table

Relevant External Links for PRXL2B Gene

GeneLoc Exon Structure for
PRXL2B

Expression for PRXL2B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRXL2B

SOURCE GeneReport for Unigene cluster for PRXL2B Gene:

Hs.462033

Evidence on tissue expression from TISSUES for PRXL2B Gene

  • Nervous system(4.8)
  • Thyroid gland(4.2)
No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRXL2B Gene

Orthologs for PRXL2B Gene

This gene was present in the common ancestor of animals.

Orthologs for PRXL2B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FAM213B 29 30
  • 98.1 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FAM213B 29 30
  • 87.14 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia FAM213B 29 30
  • 85.86 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fam213b 29
  • 83.33 (n)
Mouse
(Mus musculus)
Mammalia Fam213b 29 30
  • 83.16 (n)
OneToOne
Prxl2b 16
Oppossum
(Monodelphis domestica)
Mammalia FAM213B 30
  • 74 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fam213b 29
  • 61.11 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9472 29
Zebrafish
(Danio rerio)
Actinopterygii fam213b 29 30
  • 62.12 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea R53.5 30
  • 19 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10285 30
  • 43 (a)
OneToMany
-- 30
  • 38 (a)
OneToMany
Species where no ortholog for PRXL2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PRXL2B Gene

ENSEMBL:
Gene Tree for PRXL2B (if available)
TreeFam:
Gene Tree for PRXL2B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRXL2B: view image
Alliance of Genome Resources:
Additional Orthologs for PRXL2B

Paralogs for PRXL2B Gene

No data available for Paralogs for PRXL2B Gene

Variants for PRXL2B Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PRXL2B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PRXL2B Gene

Variant ID Type Subtype PubMed ID
esv3582248 CNV gain 25503493
nsv470684 CNV loss 18288195
nsv545077 CNV gain 21841781
nsv545082 CNV loss 21841781
nsv545083 CNV gain 21841781
nsv7171 OTHER inversion 18451855
nsv829648 CNV loss 17160897
nsv951592 CNV deletion 24416366

Variation tolerance for PRXL2B Gene

Gene Damage Index Score: 0.94; 19.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRXL2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRXL2B
Leiden Open Variation Database (LOVD)
PRXL2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRXL2B Gene

Disorders for PRXL2B Gene

Additional Disease Information for PRXL2B

No disorders were found for PRXL2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRXL2B Gene

Publications for PRXL2B Gene

  1. Preferential localization of prostamide/prostaglandin F synthase in myelin sheaths of the central nervous system. (PMID: 20950588) Yoshikawa K … Shimada A (Brain research 2011) 2 3
  2. Molecular characterization of a novel type of prostamide/prostaglandin F synthase, belonging to the thioredoxin-like superfamily. (PMID: 18006499) Moriuchi H … Watanabe K (The Journal of biological chemistry 2008) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A. (PMID: 33001583) Mao CG … Deng B (Thoracic cancer 2020) 3

Products for PRXL2B Gene

Sources for PRXL2B Gene