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Aliases for PRXL2A Gene

Aliases for PRXL2A Gene

  • Peroxiredoxin Like 2A 2 3 5
  • Peroxiredoxin-Like 2 Activated In M-CSF Stimulated Monocytes 2 3 4
  • Redox-Regulatory Protein FAM213A 3 4
  • Peroxiredoxin-Like 2A 3 4
  • Adiporedoxin 2 3
  • C10orf58 3 4
  • FAM213A 3 4
  • PAMM 3 4
  • Peroxiredoxin (PRX)-Like 2 Activated In M-CSF Stimulated Monocytes 3
  • Family With Sequence Similarity 213, Member A 2
  • Family With Sequence Similarity 213 Member A 3
  • Chromosome 10 Open Reading Frame 58 2
  • Redox-Regulatory Protein PAMM 3
  • UPF0765 Protein C10orf58 3
  • Protein PAMM 4
  • Adrx 3

External Ids for PRXL2A Gene

Previous HGNC Symbols for PRXL2A Gene

  • C10orf58
  • FAM213A

Previous GeneCards Identifiers for PRXL2A Gene

  • GC10P082714
  • GC10P082426

Summaries for PRXL2A Gene

GeneCards Summary for PRXL2A Gene

PRXL2A (Peroxiredoxin Like 2A) is a Protein Coding gene.

UniProtKB/Swiss-Prot for PRXL2A Gene

  • Involved in redox regulation of the cell (PubMed:26438880, PubMed:19951071). Acts as an antioxidant (PubMed:19951071, PubMed:26438880). Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation (PubMed:19951071). May affect bone resorption and help to maintain bone mass (PubMed:19951071). Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway (PubMed:26438880).

Gene Wiki entry for PRXL2A Gene

Additional gene information for PRXL2A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRXL2A Gene

Genomics for PRXL2A Gene

GeneHancer (GH) Regulatory Elements for PRXL2A Gene

Promoters and enhancers for PRXL2A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J080406 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 619.6 +3.9 3917 10.7 ELF3 CBFA2T2 POLR2A CEBPG MAFK TFE3 TRIM24 SP7 ZNF174 SP1 PRXL2A DYDC2 LOC642361 DYDC1 MBL1P PLAC9 ANXA11 PIR57963
GH10J080453 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 27.2 +56.5 56528 22.7 SP1 ZFX ZKSCAN8 ZNF148 NKRF MLLT1 ZNF121 GTF2F1 ZNF687 NFIB TSPAN14 PRXL2A LOC101929574 DYDC1 DYDC2 ANXA11 PLAC9 MBL1P SH2D4B PIR41876
GH10J080356 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 19.5 -50.6 -50628 1.6 RFX1 POLR2A NRF1 BMI1 USF1 SMAD5 SIN3A HNF4A USF2 DYDC1 PRXL2A DYDC2
GH10J080492 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 11.4 +92.5 92502 15 MTA3 ZFX CC2D1A ELF3 CTCF CBFA2T2 MLLT1 CEBPG GTF2F1 CSDE1 TSPAN14 PRXL2A DYDC1 DYDC2 LOC101929574 ANXA11 PIR41876
GH10J080483 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 11.4 +80.0 80024 9.5 ZNF652 ELF3 CBFA2T2 CEBPG ZNF384 TFE3 ELF1 SP1 HNF1A PPARG TSPAN14 PRXL2A DYDC1 DYDC2 LOC101929574 ANXA11 PIR41876
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRXL2A on UCSC Golden Path with GeneCards custom track

Genomic Locations for PRXL2A Gene

Genomic Locations for PRXL2A Gene
chr10:80,407,829-80,437,115
(GRCh38/hg38)
Size:
29,287 bases
Orientation:
Plus strand
chr10:82,167,585-82,192,753
(GRCh37/hg19)
Size:
25,169 bases
Orientation:
Plus strand

Genomic View for PRXL2A Gene

Genes around PRXL2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRXL2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRXL2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRXL2A Gene

Proteins for PRXL2A Gene

  • Protein details for PRXL2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRX8-PXL2A_HUMAN
    Recommended name:
    Peroxiredoxin-like 2A
    Protein Accession:
    Q9BRX8
    Secondary Accessions:
    • B2RD81
    • Q6UW08
    • Q8N2K3
    • Q8NBK9
    • Q96JR0

    Protein attributes for PRXL2A Gene

    Size:
    229 amino acids
    Molecular mass:
    25764 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The active site cysteines correspond to the redox-active cysteines of peroxiredoxins.
    SequenceCaution:
    • Sequence=AAK55527.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG37828.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for PRXL2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRXL2A Gene

Post-translational modifications for PRXL2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PRXL2A Gene

Domains & Families for PRXL2A Gene

Gene Families for PRXL2A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for PRXL2A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRXL2A Gene

GenScript: Design optimal peptide antigens:
  • UPF0765 protein C10orf58 (CJ058_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BRX8

UniProtKB/Swiss-Prot:

PXL2A_HUMAN :
  • Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily.
Family:
  • Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily.
genes like me logo Genes that share domains with PRXL2A: view

Function for PRXL2A Gene

Molecular function for PRXL2A Gene

UniProtKB/Swiss-Prot Function:
Involved in redox regulation of the cell (PubMed:26438880, PubMed:19951071). Acts as an antioxidant (PubMed:19951071, PubMed:26438880). Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation (PubMed:19951071). May affect bone resorption and help to maintain bone mass (PubMed:19951071). Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway (PubMed:26438880).
UniProtKB/Swiss-Prot Induction:
Up-regulated by CSF1 in peripheral blood mononuclear cells (PBMCs). This induction is reduced in the presence of TNFSF11.

Phenotypes From GWAS Catalog for PRXL2A Gene

Gene Ontology (GO) - Molecular Function for PRXL2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016209 antioxidant activity IBA,IDA 19951071
genes like me logo Genes that share ontologies with PRXL2A: view
genes like me logo Genes that share phenotypes with PRXL2A: view

Animal Models for PRXL2A Gene

MGI Knock Outs for PRXL2A:
  • Prxl2a Prxl2a<tm1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

miRNA for PRXL2A Gene

miRTarBase miRNAs that target PRXL2A

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRXL2A

Clone Products

  • Applied Biological Materials (abm): Clones for PRXL2A - Now 50% OFF >
  • * PRXL2A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * PRXL2A tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRXL2A Gene

Localization for PRXL2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRXL2A Gene

Cytoplasm. Secreted. Note=Secreted from mature adipocytes but not from preadipocytes. {ECO:0000269 PubMed:26438880}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRXL2A gene
Compartment Confidence
extracellular 4
plasma membrane 1
endoplasmic reticulum 1
mitochondrion 0
cytosol 0

Gene Ontology (GO) - Cellular Components for PRXL2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IDA,IBA 19951071
genes like me logo Genes that share ontologies with PRXL2A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRXL2A Gene

Pathways & Interactions for PRXL2A Gene

PathCards logo

SuperPathways for PRXL2A Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRXL2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045670 regulation of osteoclast differentiation IDA 19951071
GO:0055114 oxidation-reduction process IBA,IDA 19951071
GO:0098869 cellular oxidant detoxification IEA --
genes like me logo Genes that share ontologies with PRXL2A: view

No data available for Pathways by source and SIGNOR curated interactions for PRXL2A Gene

Drugs & Compounds for PRXL2A Gene

No Compound Related Data Available

Transcripts for PRXL2A Gene

Unigene Clusters for PRXL2A Gene

Family with sequence similarity 213, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRXL2A

Clone Products

  • Applied Biological Materials (abm): Clones for PRXL2A - Now 50% OFF >
  • * PRXL2A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * PRXL2A tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for PRXL2A Gene

No ASD Table

Relevant External Links for PRXL2A Gene

GeneLoc Exon Structure for
PRXL2A
ECgene alternative splicing isoforms for
PRXL2A

Expression for PRXL2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of PRXL2A Gene:

PRXL2A

SOURCE GeneReport for Unigene cluster for PRXL2A Gene:

Hs.500333

mRNA Expression by UniProt/SwissProt for PRXL2A Gene:

Q9BRX8-PXL2A_HUMAN
Tissue specificity: Expressed in CSF1 and TNFSF11-stimulated CD14(+) peripheral blood mononuclear cells (PBMCs).

Evidence on tissue expression from TISSUES for PRXL2A Gene

  • Heart(4)
  • Liver(4)
  • Muscle(4)
genes like me logo Genes that share expression patterns with PRXL2A: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRXL2A Gene

Orthologs for PRXL2A Gene

This gene was present in the common ancestor of animals.

Orthologs for PRXL2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM213A 35 34
  • 99.27 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FAM213A 35 34
  • 88.23 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FAM213A 35 34
  • 88.21 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1309676 34
  • 84.5 (n)
mouse
(Mus musculus)
Mammalia Fam213a 35 34
  • 83.88 (n)
OneToOne
Prxl2a 17
platypus
(Ornithorhynchus anatinus)
Mammalia FAM213A 35
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM213A 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves C10ORF58 35 34
  • 72.8 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM213A 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c10orf58 34
  • 70.09 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6886 34
zebrafish
(Danio rerio)
Actinopterygii fam213aa 35 34
  • 66.51 (n)
OneToMany
fam213ab 35
  • 55 (a)
OneToMany
wufb06a02 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1007 34
worm
(Caenorhabditis elegans)
Secernentea R53.5 35 34
  • 50.9 (n)
OneToMany
Species where no ortholog for PRXL2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRXL2A Gene

ENSEMBL:
Gene Tree for PRXL2A (if available)
TreeFam:
Gene Tree for PRXL2A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRXL2A: view image

Paralogs for PRXL2A Gene

Pseudogenes.org Pseudogenes for PRXL2A Gene

genes like me logo Genes that share paralogs with PRXL2A: view

No data available for Paralogs for PRXL2A Gene

Variants for PRXL2A Gene

Sequence variations from dbSNP and Humsavar for PRXL2A Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000031589 -- 80,428,649(+) A/G/T intron_variant
rs1000102857 -- 80,417,663(+) A/G intron_variant
rs1000130282 -- 80,428,616(+) C/G intron_variant
rs1000277654 -- 80,421,317(+) G/A intron_variant
rs1000332835 -- 80,415,032(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PRXL2A Gene

Variant ID Type Subtype PubMed ID
nsv1051052 CNV gain 25217958
nsv1141879 OTHER inversion 24896259
nsv469837 CNV loss 16826518
nsv524518 CNV loss 19592680
nsv831923 CNV loss 17160897
nsv831924 CNV loss 17160897

Variation tolerance for PRXL2A Gene

Residual Variation Intolerance Score: 64.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRXL2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRXL2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRXL2A Gene

Disorders for PRXL2A Gene

No disorders were found for PRXL2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRXL2A Gene

Publications for PRXL2A Gene

  1. Adipocyte-derived PAMM suppresses macrophage inflammation by inhibiting MAPK signalling. (PMID: 26438880) Guo F … Fu M (The Biochemical journal 2015) 2 3 4 58
  2. PAMM: a redox regulatory protein that modulates osteoclast differentiation. (PMID: 19951071) Xu Y … Battaglino RA (Antioxidants & redox signaling 2010) 2 3 4 58
  3. Adiporedoxin suppresses endothelial activation via inhibiting MAPK and NF-κB signaling. (PMID: 27941911) He H … Fu M (Scientific reports 2016) 2 3 58
  4. Adiporedoxin, an upstream regulator of ER oxidative folding and protein secretion in adipocytes. (PMID: 26629401) Jedrychowski MP … Pilch PF (Molecular metabolism 2015) 2 3 58
  5. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58

Products for PRXL2A Gene

Sources for PRXL2A Gene

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